TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-RNO-187042 TRKA activation by NGF 2.12312325889079e-06 -13.062622318101 7 4 0.0347826086956522 115 7166 24225,59109,81737,310738 Bdnf,Ntrk1,Ntf3,Ngf R-RNO-198745 Signalling to STAT3 4.19366284370288e-06 -12.3819360188679 8 4 0.0347826086956522 115 7166 310738,24225,59109,81737 Ngf,Bdnf,Ntrk1,Ntf3 R-RNO-187015 Activation of TRKA receptors 1.2271513611969e-05 -11.3082299480908 10 4 0.0347826086956522 115 7166 59109,24225,81737,310738 Ntrk1,Bdnf,Ntf3,Ngf R-RNO-193648 NRAGE signals death through JNK 3.68628979728389e-05 -10.2083049877377 40 6 0.0521739130434783 115 7166 81737,24225,293024,310999,295378,310738 Ntf3,Bdnf,Akap13,Plekhg5,Vav3,Ngf R-RNO-193704 p75 NTR receptor-mediated signalling 0.000169124065129052 -8.68487799918083 74 7 0.0608695652173913 115 7166 295378,83537,310999,293024,24225,81737,310738 Vav3,Smpd2,Plekhg5,Akap13,Bdnf,Ntf3,Ngf R-RNO-167021 PLC-gamma1 signalling 0.000187165599678602 -8.58351677320779 34 5 0.0434782608695652 115 7166 310738,59109,24225,81737,24681 Ngf,Ntrk1,Bdnf,Ntf3,Prkcg R-RNO-177504 Retrograde neurotrophin signalling 0.000202535423631605 -8.50459575520231 19 4 0.0347826086956522 115 7166 24225,59109,81737,310738 Bdnf,Ntrk1,Ntf3,Ngf R-RNO-204998 Cell death signalling via NRAGE, NRIF and NADE 0.000206639702622173 -8.48453384828839 54 6 0.0521739130434783 115 7166 81737,24225,293024,310999,295378,310738 Ntf3,Bdnf,Akap13,Plekhg5,Vav3,Ngf R-RNO-193681 Ceramide signalling 0.000757948897356179 -7.18489459233049 3 2 0.0173913043478261 115 7166 83537,310738 Smpd2,Ngf R-RNO-216083 Integrin cell surface interactions 0.000963364774404215 -6.94507842826866 48 5 0.0434782608695652 115 7166 445442,315744,313785,311144,83727 Thbs1,Itga11,Icam5,Itga4,Fbn1 R-RNO-202430 Translocation of ZAP-70 to Immunological synapse 0.00102406469150342 -6.88397557906398 13 3 0.0260869565217391 115 7166 294270,294269,309622 RT1-Db1,RT1-Da,RT1-Bb R-RNO-194306 Neurophilin interactions with VEGF and VEGFR 0.00149997682517107 -6.50230562087928 4 2 0.0173913043478261 115 7166 81527,246331 Nrp2,Nrp1 R-RNO-202427 Phosphorylation of CD3 and TCR zeta chains 0.0019359672696319 -6.24714819645253 16 3 0.0260869565217391 115 7166 294270,309622,294269 RT1-Db1,RT1-Bb,RT1-Da R-RNO-375280 Amine ligand-binding receptors 0.00201326516767449 -6.20799741339201 34 4 0.0347826086956522 115 7166 24473,29413,25324,53949 Htr1a,Adra1d,Htr4,Chrm5 R-RNO-389948 PD-1 signaling 0.00275581986062043 -5.89404029058654 18 3 0.0260869565217391 115 7166 294270,309622,294269 RT1-Db1,RT1-Bb,RT1-Da R-RNO-1474244 Extracellular matrix organization 0.00440260050633057 -5.42555988847788 198 9 0.0782608695652174 115 7166 315744,81008,685781,445442,83727,311144,313785,305253,25724 Itga11,Itga7,Ddr2,Thbs1,Fbn1,Itga4,Icam5,Adamts3,Itgb4 R-RNO-1266738 Developmental Biology 0.00458945137895204 -5.38399478733618 487 16 0.139130434782609 115 7166 406228,316539,360573,245956,360854,302934,29458,295378,246331,308565,140729,293847,25443,310207,171287,292949 Krt2,Epha4,Ksr1,Scn3b,Arpc5,Ppl,Neurod1,Vav3,Nrp1,Klk8,Cacng8,Dusp9,Fgf10,Sema5a,Epha7,Perp R-RNO-202433 Generation of second messenger molecules 0.00564248776712354 -5.17743021726367 23 3 0.0260869565217391 115 7166 294269,309622,294270 RT1-Da,RT1-Bb,RT1-Db1 R-RNO-416482 G alpha (12/13) signalling events 0.00565059193313064 -5.17599497238568 45 4 0.0347826086956522 115 7166 293024,295378,310999,29413 Akap13,Vav3,Plekhg5,Adra1d R-RNO-425986 Sodium/Proton exchangers 0.00671130013110644 -5.00396258654313 8 2 0.0173913043478261 115 7166 24783,24785 Slc9a2,Slc9a4 R-RNO-428643 Organic anion transporters 0.00853874897300296 -4.76314077219309 9 2 0.0173913043478261 115 7166 116638,266767 Slc17a7,Slc17a8 R-RNO-6809371 Formation of the cornified envelope 0.00889607525742185 -4.72214508181749 27 3 0.0260869565217391 115 7166 302934,308565,292949 Ppl,Klk8,Perp R-RNO-416476 G alpha (q) signalling events 0.012081875627872 -4.41604883132023 155 7 0.0608695652173913 115 7166 499194,53949,25666,84022,314904,309242,29413 Nmb,Chrm5,Dgkg,Ghsr,Arhgef25,Gna14,Adra1d R-RNO-390666 Serotonin receptors 0.0127749119255684 -4.36027203719649 11 2 0.0173913043478261 115 7166 25324,24473 Htr4,Htr1a R-RNO-373076 Class A/1 (Rhodopsin-like receptors) 0.0132223166040163 -4.32584922511342 277 10 0.0869565217391304 115 7166 25324,499194,53949,29413,84348,24473,84022,66024,295401,54258 Htr4,Nmb,Chrm5,Adra1d,Ackr3,Htr1a,Ghsr,Npy2r,Plppr4,Cxcr1 R-RNO-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 0.0134263517151499 -4.31053595723862 122 6 0.0521739130434783 115 7166 140729,24406,25743,24681,25302,29707 Cacng8,Grik4,Kcnj6,Prkcg,Chrna7,Gabra5 R-RNO-3928665 EPH-ephrin mediated repulsion of cells 0.0142369022491156 -4.25191793534898 32 3 0.0260869565217391 115 7166 316539,295378,171287 Epha4,Vav3,Epha7 R-RNO-5576892 Phase 0 - rapid depolarisation 0.0142369022491156 -4.25191793534898 32 3 0.0260869565217391 115 7166 84488,140729,140727 Fgf13,Cacng8,Cacng6 R-RNO-112316 Neuronal System 0.0169664841653423 -4.07651540061474 288 10 0.0869565217391304 115 7166 24406,29548,24681,25302,29707,24409,25743,140729,116638,307234 Grik4,Homer3,Prkcg,Chrna7,Gabra5,Grin2a,Kcnj6,Cacng8,Slc17a7,Kcng2 R-RNO-3000157 Laminin interactions 0.0177425651507408 -4.03178871555605 13 2 0.0173913043478261 115 7166 81008,25724 Itga7,Itgb4 R-RNO-5576891 Cardiac conduction 0.0187553812924849 -3.97627456547713 96 5 0.0434782608695652 115 7166 56817,140729,140727,689560,84488 Kcnip2,Cacng8,Cacng6,Ryr2,Fgf13 R-RNO-166520 Signalling by NGF 0.0197870963409963 -3.92272525368005 384 12 0.104347826086957 115 7166 293847,83537,360573,25443,310738,81737,293024,24225,59109,310999,24681,295378 Dusp9,Smpd2,Ksr1,Fgf10,Ngf,Ntf3,Akap13,Bdnf,Ntrk1,Plekhg5,Prkcg,Vav3 R-RNO-2682334 EPH-Ephrin signaling 0.0211611297386559 -3.8555892831216 66 4 0.0347826086956522 115 7166 316539,295378,360854,171287 Epha4,Vav3,Arpc5,Epha7 R-RNO-112315 Transmission across Chemical Synapses 0.0253626878542261 -3.67447616708677 180 7 0.0608695652173913 115 7166 116638,25743,24406,140729,29707,24681,25302 Slc17a7,Kcnj6,Grik4,Cacng8,Gabra5,Prkcg,Chrna7 R-RNO-1793185 Chondroitin sulfate/dermatan sulfate metabolism 0.0275858205003597 -3.59045338826074 41 3 0.0260869565217391 115 7166 291770,117108,64544 Chst9,B3gat1,B3gat2 R-RNO-205017 NFG and proNGF binds to p75NTR 0.0318406743166069 -3.44701073994482 2 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-428776 Class II GLUTs 0.0318406743166069 -3.44701073994482 2 1 0.00869565217391304 115 7166 501925 Slc2a9 R-RNO-6805567 Keratinization 0.0377047595401673 -3.27796894474695 79 4 0.0347826086956522 115 7166 292949,302934,406228,308565 Perp,Ppl,Krt2,Klk8 R-RNO-187706 Signalling to p38 via RIT and RIN 0.0433562077459264 -3.13830538540974 202 7 0.0608695652173913 115 7166 25443,310738,81737,293847,24225,59109,360573 Fgf10,Ngf,Ntf3,Dusp9,Bdnf,Ntrk1,Ksr1 R-RNO-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 0.0439623478767507 -3.12442174148371 21 2 0.0173913043478261 115 7166 117108,64544 B3gat1,B3gat2 R-RNO-170984 ARMS-mediated activation 0.0443302858455149 -3.11608718211795 203 7 0.0608695652173913 115 7166 360573,293847,81737,59109,24225,310738,25443 Ksr1,Dusp9,Ntf3,Ntrk1,Bdnf,Ngf,Fgf10 R-RNO-170968 Frs2-mediated activation 0.0453184626491905 -3.094040765525 204 7 0.0608695652173913 115 7166 81737,293847,59109,24225,360573,25443,310738 Ntf3,Dusp9,Ntrk1,Bdnf,Ksr1,Fgf10,Ngf R-RNO-169893 Prolonged ERK activation events 0.0463207903052678 -3.07216438400483 205 7 0.0608695652173913 115 7166 310738,25443,360573,59109,24225,81737,293847 Ngf,Fgf10,Ksr1,Ntrk1,Bdnf,Ntf3,Dusp9 R-RNO-2132295 MHC class II antigen presentation 0.0472774885072366 -3.05172102685448 85 4 0.0347826086956522 115 7166 294270,25599,309622,294269 RT1-Db1,Cd74,RT1-Bb,RT1-Da R-RNO-3238698 WNT ligand biogenesis and trafficking 0.0478621880505805 -3.03942947981646 22 2 0.0173913043478261 115 7166 84426,303586 Wnt4,Wnt9b R-RNO-3928663 EPHA-mediated growth cone collapse 0.0478621880505805 -3.03942947981646 22 2 0.0173913043478261 115 7166 316539,171287 Epha4,Epha7 R-RNO-167044 Signalling to RAS 0.0483680964033705 -3.02891484782408 207 7 0.0608695652173913 115 7166 293847,81737,59109,24225,360573,25443,310738 Dusp9,Ntf3,Ntrk1,Bdnf,Ksr1,Fgf10,Ngf R-RNO-1500931 Cell-Cell communication 0.0489927511850346 -3.01608292681427 86 4 0.0347826086956522 115 7166 25724,50646,29163,498281 Itgb4,Ptk2b,Cdh9,Nectin4 R-RNO-446728 Cell junction organization 0.0504375280388486 -2.98701977703939 52 3 0.0260869565217391 115 7166 25724,29163,498281 Itgb4,Cdh9,Nectin4 R-RNO-5576893 Phase 2 - plateau phase 0.0518831118875582 -2.95876193892031 23 2 0.0173913043478261 115 7166 140727,140729 Cacng6,Cacng8 R-RNO-187687 Signalling to ERKs 0.0548544118430706 -2.90307266079969 213 7 0.0608695652173913 115 7166 310738,25443,360573,81737,293847,59109,24225 Ngf,Fgf10,Ksr1,Ntf3,Dusp9,Ntrk1,Bdnf R-RNO-2142753 Arachidonic acid metabolism 0.055336931299034 -2.89431475793112 54 3 0.0260869565217391 115 7166 29527,25426,79242 Ptgs2,Cyp1b1,Hpgd R-RNO-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.0573591929849069 -2.85842215209053 354 10 0.0869565217391304 115 7166 499194,53949,84022,25443,29413,360573,25666,293847,314904,309242 Nmb,Chrm5,Ghsr,Fgf10,Adra1d,Ksr1,Dgkg,Dusp9,Arhgef25,Gna14 R-RNO-418990 Adherens junctions interactions 0.0602690695710836 -2.8089362492854 25 2 0.0173913043478261 115 7166 29163,498281 Cdh9,Nectin4 R-RNO-388841 Costimulation by the CD28 family 0.060455388164906 -2.80584957165194 56 3 0.0260869565217391 115 7166 309622,294269,294270 RT1-Bb,RT1-Da,RT1-Db1 R-RNO-167060 NGF processing 0.0626760570946531 -2.76977576879117 4 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-71262 Carnitine synthesis 0.0626760570946531 -2.76977576879117 4 1 0.00869565217391304 115 7166 287379 Shmt1 R-RNO-167827 The proton buffering model 0.0626760570946531 -2.76977576879117 4 1 0.00869565217391304 115 7166 54315 Ucp2 R-RNO-209563 Axonal growth stimulation 0.0626760570946531 -2.76977576879117 4 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 0.0626760570946531 -2.76977576879117 4 1 0.00869565217391304 115 7166 29458 Neurod1 R-RNO-167826 The fatty acid cycling model 0.0626760570946531 -2.76977576879117 4 1 0.00869565217391304 115 7166 54315 Ucp2 R-RNO-166187 Mitochondrial Uncoupling Proteins 0.0626760570946531 -2.76977576879117 4 1 0.00869565217391304 115 7166 54315 Ucp2 R-RNO-422475 Axon guidance 0.0686240083408316 -2.67911282966368 366 10 0.0869565217391304 115 7166 316539,246331,360573,245956,360854,293847,310207,25443,295378,171287 Epha4,Nrp1,Ksr1,Scn3b,Arpc5,Dusp9,Sema5a,Fgf10,Vav3,Epha7 R-RNO-399719 Trafficking of AMPA receptors 0.0690831334310073 -2.67244466727945 27 2 0.0173913043478261 115 7166 24681,140729 Prkcg,Cacng8 R-RNO-399721 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 0.0690831334310073 -2.67244466727945 27 2 0.0173913043478261 115 7166 140729,24681 Cacng8,Prkcg R-RNO-500792 GPCR ligand binding 0.0696226259467735 -2.66466567902844 367 10 0.0869565217391304 115 7166 54258,66024,295401,29413,84348,84022,24473,499194,25324,53949 Cxcr1,Npy2r,Plppr4,Adra1d,Ackr3,Ghsr,Htr1a,Nmb,Htr4,Chrm5 R-RNO-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 0.0722108689972725 -2.62816470428496 98 4 0.0347826086956522 115 7166 266767,24783,24785,116638 Slc17a8,Slc9a2,Slc9a4,Slc17a7 R-RNO-70350 Fructose catabolism 0.0777266370213739 -2.55455726154958 5 1 0.00869565217391304 115 7166 24188 Aldh1a1 R-RNO-114516 Disinhibition of SNARE formation 0.0777266370213739 -2.55455726154958 5 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-193670 p75NTR negatively regulates cell cycle via SC1 0.0777266370213739 -2.55455726154958 5 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-70921 Histidine catabolism 0.0777266370213739 -2.55455726154958 5 1 0.00869565217391304 115 7166 24443 Hdc R-RNO-5661270 Catabolism of glucuronate to xylulose-5-phosphate 0.0777266370213739 -2.55455726154958 5 1 0.00869565217391304 115 7166 290277 Cryl1 R-RNO-2142700 Synthesis of Lipoxins (LX) 0.0777266370213739 -2.55455726154958 5 1 0.00869565217391304 115 7166 79242 Hpgd R-RNO-390648 Muscarinic acetylcholine receptors 0.0777266370213739 -2.55455726154958 5 1 0.00869565217391304 115 7166 53949 Chrm5 R-RNO-397014 Muscle contraction 0.0795319693021956 -2.53159620856692 143 5 0.0434782608695652 115 7166 84488,56817,140727,140729,689560 Fgf13,Kcnip2,Cacng6,Cacng8,Ryr2 R-RNO-5675221 Negative regulation of MAPK pathway 0.083030343245773 -2.48854915671972 30 2 0.0173913043478261 115 7166 293847,360573 Dusp9,Ksr1 R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs 0.0878564223522074 -2.43205136113374 31 2 0.0173913043478261 115 7166 259242,360854 Wipf3,Arpc5 R-RNO-5576894 Phase 1 - inactivation of fast Na+ channels 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 56817 Kcnip2 R-RNO-5626978 TNFR1-mediated ceramide production 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 83537 Smpd2 R-RNO-2142770 Synthesis of 15-eicosatetraenoic acid derivatives 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 29527 Ptgs2 R-RNO-186712 Regulation of beta-cell development 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 29458 Neurod1 R-RNO-187024 NGF-independant TRKA activation 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 59109 Ntrk1 R-RNO-190370 FGFR1b ligand binding and activation 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-205025 NADE modulates death signalling 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-420597 Nectin/Necl trans heterodimerization 0.0925376182730477 -2.38014003310435 6 1 0.00869565217391304 115 7166 498281 Nectin4 R-RNO-421270 Cell-cell junction organization 0.102810830286921 -2.2748645785247 34 2 0.0173913043478261 115 7166 498281,29163 Nectin4,Cdh9 R-RNO-446107 Type I hemidesmosome assembly 0.10711278222447 -2.23387296014878 7 1 0.00869565217391304 115 7166 25724 Itgb4 R-RNO-5652084 Fructose metabolism 0.10711278222447 -2.23387296014878 7 1 0.00869565217391304 115 7166 24188 Aldh1a1 R-RNO-428930 Thromboxane signalling through TP receptor 0.10711278222447 -2.23387296014878 7 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-390696 Adrenoceptors 0.10711278222447 -2.23387296014878 7 1 0.00869565217391304 115 7166 29413 Adra1d R-RNO-5173214 O-glycosylation of TSR domain-containing proteins 0.10711278222447 -2.23387296014878 7 1 0.00869565217391304 115 7166 445442 Thbs1 R-RNO-111367 SLBP independent Processing of Histone Pre-mRNAs 0.10711278222447 -2.23387296014878 7 1 0.00869565217391304 115 7166 501688 Lsm11 R-RNO-2672351 Stimuli-sensing channels 0.115472382072008 -2.15872389387281 74 3 0.0260869565217391 115 7166 689560,287715,140933 Ryr2,Wnk4,Trpc5 R-RNO-6794361 Interactions of neurexins and neuroligins at synapses 0.118402455060279 -2.13366582144079 37 2 0.0173913043478261 115 7166 24409,29548 Grin2a,Homer3 R-RNO-190377 FGFR2b ligand binding and activation 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-5658623 FGFRL1 modulation of FGFR1 signaling 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-400451 Free fatty acids regulate insulin secretion 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-432142 Platelet sensitization by LDL 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-70635 Urea cycle 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 29221 Arg1 R-RNO-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 501688 Lsm11 R-RNO-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 246331 Nrp1 R-RNO-1614558 Degradation of cysteine and homocysteine 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 81718 Cdo1 R-RNO-193697 p75NTR regulates axonogenesis 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-8851680 Butyrophilin (BTN) family interactions 0.121455851095465 -2.10820444770418 8 1 0.00869565217391304 115 7166 302934 Ppl R-RNO-380108 Chemokine receptors bind chemokines 0.123725035787724 -2.08969362889207 38 2 0.0173913043478261 115 7166 54258,84348 Cxcr1,Ackr3 R-RNO-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 0.129104810807263 -2.04713071763125 39 2 0.0173913043478261 115 7166 117108,64544 B3gat1,B3gat2 R-RNO-375276 Peptide ligand-binding receptors 0.132592302914591 -2.02047625031647 168 5 0.0434782608695652 115 7166 54258,84348,84022,499194,66024 Cxcr1,Ackr3,Ghsr,Nmb,Npy2r R-RNO-187037 NGF signalling via TRKA from the plasma membrane 0.134481114581504 -2.00633150183237 316 8 0.0695652173913043 115 7166 25443,310738,81737,24225,59109,24681,293847,360573 Fgf10,Ngf,Ntf3,Bdnf,Ntrk1,Prkcg,Dusp9,Ksr1 R-RNO-418592 ADP signalling through P2Y purinoceptor 1 0.135570488860861 -1.99826356093097 9 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-419408 Lysosphingolipid and LPA receptors 0.135570488860861 -1.99826356093097 9 1 0.00869565217391304 115 7166 295401 Plppr4 R-RNO-399997 Acetylcholine regulates insulin secretion 0.135570488860861 -1.99826356093097 9 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-202424 Downstream TCR signaling 0.14433369451479 -1.93562733723894 82 3 0.0260869565217391 115 7166 294269,309622,294270 RT1-Da,RT1-Bb,RT1-Db1 R-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.148098099457435 -1.90988039062371 83 3 0.0260869565217391 115 7166 313785,311144,365527 Icam5,Itga4,RT1-M6-2 R-RNO-71384 Ethanol oxidation 0.149460302158405 -1.90072445881467 10 1 0.00869565217391304 115 7166 24188 Aldh1a1 R-RNO-977441 GABA A receptor activation 0.149460302158405 -1.90072445881467 10 1 0.00869565217391304 115 7166 29707 Gabra5 R-RNO-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.149460302158405 -1.90072445881467 10 1 0.00869565217391304 115 7166 25426 Cyp1b1 R-RNO-391160 Signal regulatory protein (SIRP) family interactions 0.149460302158405 -1.90072445881467 10 1 0.00869565217391304 115 7166 50646 Ptk2b R-RNO-194138 Signaling by VEGF 0.15244778069849 -1.8809331632236 275 7 0.0608695652173913 115 7166 25443,246331,50646,293847,81527,295378,360573 Fgf10,Nrp1,Ptk2b,Dusp9,Nrp2,Vav3,Ksr1 R-RNO-416700 Other semaphorin interactions 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 310207 Sema5a R-RNO-451306 Ionotropic activity of Kainate Receptors 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 24406 Grik4 R-RNO-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 25302 Chrna7 R-RNO-445095 Interaction between L1 and Ankyrins 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 245956 Scn3b R-RNO-209560 NF-kB is activated and signals survival 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-197264 Nicotinamide salvaging 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 29527 Ptgs2 R-RNO-451308 Activation of Ca-permeable Kainate Receptor 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 24406 Grik4 R-RNO-428790 Facilitative Na+-independent glucose transporters 0.163128841184284 -1.81321495369255 11 1 0.00869565217391304 115 7166 501925 Slc2a9 R-RNO-373755 Semaphorin interactions 0.173839828136851 -1.74962093166278 47 2 0.0173913043478261 115 7166 310207,246331 Sema5a,Nrp1 R-RNO-202733 Cell surface interactions at the vascular wall 0.175295466676536 -1.74128234776278 90 3 0.0260869565217391 115 7166 311144,25599,64025 Itga4,Cd74,Cd244 R-RNO-190372 FGFR3c ligand binding and activation 0.176579600550178 -1.73398350965772 12 1 0.00869565217391304 115 7166 366061 Galnt3 R-RNO-5682910 LGI-ADAM interactions 0.176579600550178 -1.73398350965772 12 1 0.00869565217391304 115 7166 140729 Cacng8 R-RNO-190239 FGFR3 ligand binding and activation 0.176579600550178 -1.73398350965772 12 1 0.00869565217391304 115 7166 366061 Galnt3 R-RNO-205043 NRIF signals cell death from the nucleus 0.176579600550178 -1.73398350965772 12 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-209543 p75NTR recruits signalling complexes 0.176579600550178 -1.73398350965772 12 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-4641263 Regulation of FZD by ubiquitination 0.176579600550178 -1.73398350965772 12 1 0.00869565217391304 115 7166 500863 Rspo2 R-RNO-977443 GABA receptor activation 0.179601838426732 -1.71701288693741 48 2 0.0173913043478261 115 7166 25743,29707 Kcnj6,Gabra5 R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation 0.179601838426732 -1.71701288693741 48 2 0.0173913043478261 115 7166 360854,259242 Arpc5,Wipf3 R-RNO-373760 L1CAM interactions 0.185393025112436 -1.68527724731083 49 2 0.0173913043478261 115 7166 245956,246331 Scn3b,Nrp1 R-RNO-162582 Signal Transduction 0.188135291619598 -1.67059393869175 2192 40 0.347826086956522 115 7166 53949,81527,25324,499194,24856,445442,360573,360854,314904,100360552,84426,24225,81737,24473,29413,293847,309242,59109,293024,24681,295378,310999,84022,84348,50646,25666,295401,66024,303586,259242,366061,295661,25443,305922,310738,83537,500863,54258,246331,24188 Chrm5,Nrp2,Htr4,Nmb,Ttr,Thbs1,Ksr1,Arpc5,Arhgef25,Fzd7,Wnt4,Bdnf,Ntf3,Htr1a,Adra1d,Dusp9,Gna14,Ntrk1,Akap13,Prkcg,Vav3,Plekhg5,Ghsr,Ackr3,Ptk2b,Dgkg,Plppr4,Npy2r,Wnt9b,Wipf3,Galnt3,Spc25,Fgf10,Lats2,Ngf,Smpd2,Rspo2,Cxcr1,Nrp1,Aldh1a1 R-RNO-629602 Activation of Nicotinic Acetylcholine Receptors 0.189816020165437 -1.66169999086016 13 1 0.00869565217391304 115 7166 25302 Chrna7 R-RNO-399954 Sema3A PAK dependent Axon repulsion 0.189816020165437 -1.66169999086016 13 1 0.00869565217391304 115 7166 246331 Nrp1 R-RNO-622327 Postsynaptic nicotinic acetylcholine receptors 0.189816020165437 -1.66169999086016 13 1 0.00869565217391304 115 7166 25302 Chrna7 R-RNO-181431 Acetylcholine Binding And Downstream Events 0.189816020165437 -1.66169999086016 13 1 0.00869565217391304 115 7166 25302 Chrna7 R-RNO-5173105 O-linked glycosylation 0.191210996473864 -1.65437776708002 50 2 0.0173913043478261 115 7166 445442,366061 Thbs1,Galnt3 R-RNO-1474290 Collagen formation 0.191210996473864 -1.65437776708002 50 2 0.0173913043478261 115 7166 305253,25724 Adamts3,Itgb4 R-RNO-6794362 Protein-protein interactions at synapses 0.191210996473864 -1.65437776708002 50 2 0.0173913043478261 115 7166 29548,24409 Homer3,Grin2a R-RNO-194840 Rho GTPase cycle 0.199631496399946 -1.61128212995859 96 3 0.0260869565217391 115 7166 310999,295378,293024 Plekhg5,Vav3,Akap13 R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.202841486079995 -1.59533046171657 14 1 0.00869565217391304 115 7166 313262 Pappa1 R-RNO-196757 Metabolism of folate and pterines 0.202841486079995 -1.59533046171657 14 1 0.00869565217391304 115 7166 287379 Shmt1 R-RNO-416993 Trafficking of GluR2-containing AMPA receptors 0.202841486079995 -1.59533046171657 14 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-190242 FGFR1 ligand binding and activation 0.202841486079995 -1.59533046171657 14 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-399956 CRMPs in Sema3A signaling 0.202841486079995 -1.59533046171657 14 1 0.00869565217391304 115 7166 246331 Nrp1 R-RNO-202403 TCR signaling 0.20376570431241 -1.59078445345147 97 3 0.0260869565217391 115 7166 309622,294269,294270 RT1-Bb,RT1-Da,RT1-Db1 R-RNO-1630316 Glycosaminoglycan metabolism 0.20376570431241 -1.59078445345147 97 3 0.0260869565217391 115 7166 64544,291770,117108 B3gat2,Chst9,B3gat1 R-RNO-195721 Signaling by Wnt 0.206355963070312 -1.5781526253561 196 5 0.0434782608695652 115 7166 84426,24681,303586,500863,100360552 Wnt4,Prkcg,Wnt9b,Rspo2,Fzd7 R-RNO-425407 SLC-mediated transmembrane transport 0.207556966247452 -1.57234944085723 248 6 0.0521739130434783 115 7166 24785,116638,501925,24783,266767,24546 Slc9a4,Slc17a7,Slc2a9,Slc9a2,Slc17a8,Slco2a1 R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-879518 Transport of organic anions 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 24546 Slco2a1 R-RNO-193639 p75NTR signals via NF-kB 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 310738 Ngf R-RNO-5099900 WNT5A-dependent internalization of FZD4 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-112409 RAF-independent MAPK1/3 activation 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 293847 Dusp9 R-RNO-422085 Synthesis, secretion, and deacylation of Ghrelin 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 301265 Pla2g7 R-RNO-3000171 Non-integrin membrane-ECM interactions 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 685781 Ddr2 R-RNO-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 25426 Cyp1b1 R-RNO-2453902 The canonical retinoid cycle in rods (twilight vision) 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 24856 Ttr R-RNO-451326 Activation of Kainate Receptors upon glutamate binding 0.215659331315225 -1.53405528617651 15 1 0.00869565217391304 115 7166 24406 Grik4 R-RNO-109688 Cleavage of Growing Transcript in the Termination Region 0.226555743724785 -1.48476425517874 56 2 0.0173913043478261 115 7166 361859,501688 Cdc40,Lsm11 R-RNO-73856 RNA Polymerase II Transcription Termination 0.226555743724785 -1.48476425517874 56 2 0.0173913043478261 115 7166 501688,361859 Lsm11,Cdc40 R-RNO-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0.228272836683545 -1.47721371332435 16 1 0.00869565217391304 115 7166 29527 Ptgs2 R-RNO-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.228272836683545 -1.47721371332435 16 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-392518 Signal amplification 0.228272836683545 -1.47721371332435 16 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-1482801 Acyl chain remodelling of PS 0.228272836683545 -1.47721371332435 16 1 0.00869565217391304 115 7166 85311 Pla1a R-RNO-983712 Ion channel transport 0.230675676762578 -1.466742551686 153 4 0.0347826086956522 115 7166 689560,29707,287715,140933 Ryr2,Gabra5,Wnk4,Trpc5 R-RNO-5674135 MAP2K and MAPK activation 0.240685231618658 -1.42426529204282 17 1 0.00869565217391304 115 7166 360573 Ksr1 R-RNO-190241 FGFR2 ligand binding and activation 0.240685231618658 -1.42426529204282 17 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-2028269 Signaling by Hippo 0.240685231618658 -1.42426529204282 17 1 0.00869565217391304 115 7166 305922 Lats2 R-RNO-5654221 Phospholipase C-mediated cascade; FGFR2 0.240685231618658 -1.42426529204282 17 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.250384385302342 -1.3847580007168 60 2 0.0173913043478261 115 7166 360854,259242 Arpc5,Wipf3 R-RNO-975298 Ligand-gated ion channel transport 0.252899694953218 -1.37476233150221 18 1 0.00869565217391304 115 7166 29707 Gabra5 R-RNO-445144 Signal transduction by L1 0.252899694953218 -1.37476233150221 18 1 0.00869565217391304 115 7166 246331 Nrp1 R-RNO-198203 PI3K/AKT activation 0.25472197403045 -1.36758262655067 109 3 0.0260869565217391 115 7166 59109,25443,310738 Ntrk1,Fgf10,Ngf R-RNO-109582 Hemostasis 0.262995499830773 -1.33561835786038 435 9 0.0782608695652174 115 7166 306761,25666,445442,309242,295378,24681,64025,311144,25599 F12,Dgkg,Thbs1,Gna14,Vav3,Prkcg,Cd244,Itga4,Cd74 R-RNO-2022870 Chondroitin sulfate biosynthesis 0.264919355705912 -1.32832981740096 19 1 0.00869565217391304 115 7166 291770 Chst9 R-RNO-5669034 TNFs bind their physiological receptors 0.264919355705912 -1.32832981740096 19 1 0.00869565217391304 115 7166 500592 Tnfrsf25 R-RNO-194315 Signaling by Rho GTPases 0.273923658241984 -1.29490583097051 273 6 0.0521739130434783 115 7166 293024,259242,295378,360854,310999,295661 Akap13,Wipf3,Vav3,Arpc5,Plekhg5,Spc25 R-RNO-114508 Effects of PIP2 hydrolysis 0.276747293872965 -1.284650485678 20 1 0.00869565217391304 115 7166 25666 Dgkg R-RNO-5654688 SHC-mediated cascade:FGFR1 0.276747293872965 -1.284650485678 20 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-5654689 PI-3K cascade:FGFR1 0.276747293872965 -1.284650485678 20 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-71291 Metabolism of amino acids and derivatives 0.278137615706875 -1.27963926724542 220 5 0.0434782608695652 115 7166 81718,29221,685325,287379,24443 Cdo1,Arg1,Ddo,Shmt1,Hdc R-RNO-210500 Glutamate Neurotransmitter Release Cycle 0.288386541171878 -1.24345354188679 21 1 0.00869565217391304 115 7166 116638 Slc17a7 R-RNO-1236977 Endosomal/Vacuolar pathway 0.288386541171878 -1.24345354188679 21 1 0.00869565217391304 115 7166 365527 RT1-M6-2 R-RNO-196807 Nicotinate metabolism 0.288386541171878 -1.24345354188679 21 1 0.00869565217391304 115 7166 29527 Ptgs2 R-RNO-5673000 RAF activation 0.288386541171878 -1.24345354188679 21 1 0.00869565217391304 115 7166 360573 Ksr1 R-RNO-76002 Platelet activation, signaling and aggregation 0.296885900847359 -1.21440738622361 226 5 0.0434782608695652 115 7166 309242,295378,24681,25666,445442 Gna14,Vav3,Prkcg,Dgkg,Thbs1 R-RNO-5654699 SHC-mediated cascade:FGFR2 0.299840081803121 -1.20450600710954 22 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-5654693 FRS-mediated FGFR1 signaling 0.299840081803121 -1.20450600710954 22 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-5654695 PI-3K cascade:FGFR2 0.299840081803121 -1.20450600710954 22 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-70895 Branched-chain amino acid catabolism 0.299840081803121 -1.20450600710954 22 1 0.00869565217391304 115 7166 287379 Shmt1 R-RNO-1614635 Sulfur amino acid metabolism 0.299840081803121 -1.20450600710954 22 1 0.00869565217391304 115 7166 81718 Cdo1 R-RNO-422356 Regulation of insulin secretion 0.304119768569419 -1.19033367960661 69 2 0.0173913043478261 115 7166 309242,307234 Gna14,Kcng2 R-RNO-5365859 RA biosynthesis pathway 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 24188 Aldh1a1 R-RNO-3295583 TRP channels 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 140933 Trpc5 R-RNO-75067 Processing of Capped Intronless Pre-mRNA 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 501688 Lsm11 R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 25743 Kcnj6 R-RNO-111997 CaM pathway 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-2426168 Activation of gene expression by SREBF (SREBP) 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 246074 Scd R-RNO-1296041 Activation of G protein gated Potassium channels 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 25743 Kcnj6 R-RNO-1296059 G protein gated Potassium channels 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 25743 Kcnj6 R-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 306761 F12 R-RNO-111933 Calmodulin induced events 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-3000178 ECM proteoglycans 0.311110853160177 -1.16760598928341 23 1 0.00869565217391304 115 7166 81008 Itga7 R-RNO-71387 Metabolism of carbohydrates 0.312674372292424 -1.1625929740892 231 5 0.0434782608695652 115 7166 291770,117108,24188,64544,290277 Chst9,B3gat1,Aldh1a1,B3gat2,Cryl1 R-RNO-418594 G alpha (i) signalling events 0.319934343575079 -1.13963948056779 178 4 0.0347826086956522 115 7166 66024,54258,84348,24473 Npy2r,Cxcr1,Ackr3,Htr1a R-RNO-5654700 FRS-mediated FGFR2 signaling 0.322201746603382 -1.13257738738685 24 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-2871809 FCERI mediated Ca+2 mobilization 0.322201746603382 -1.13257738738685 24 1 0.00869565217391304 115 7166 295378 Vav3 R-RNO-5694530 Cargo concentration in the ER 0.322201746603382 -1.13257738738685 24 1 0.00869565217391304 115 7166 361705 Cnih2 R-RNO-4086400 PCP/CE pathway 0.327838359240886 -1.11523459925979 73 2 0.0173913043478261 115 7166 24681,100360552 Prkcg,Fzd7 R-RNO-389661 Glyoxylate metabolism and glycine degradation 0.333115608146167 -1.0992656776417 25 1 0.00869565217391304 115 7166 685325 Ddo R-RNO-111996 Ca-dependent events 0.333115608146167 -1.0992656776417 25 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-5218920 VEGFR2 mediated vascular permeability 0.333115608146167 -1.0992656776417 25 1 0.00869565217391304 115 7166 295378 Vav3 R-RNO-190236 Signaling by FGFR 0.333737414168256 -1.09740078033602 74 2 0.0173913043478261 115 7166 366061,25443 Galnt3,Fgf10 R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures 0.343855239163688 -1.06753452656143 26 1 0.00869565217391304 115 7166 25724 Itgb4 R-RNO-5654726 Negative regulation of FGFR1 signaling 0.35442339707596 -1.037263043593 27 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-1489509 DAG and IP3 signaling 0.35442339707596 -1.037263043593 27 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-211976 Endogenous sterols 0.35442339707596 -1.037263043593 27 1 0.00869565217391304 115 7166 25426 Cyp1b1 R-RNO-5654696 Downstream signaling of activated FGFR2 0.375056107689238 -0.980679643699123 29 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-5654727 Negative regulation of FGFR2 signaling 0.375056107689238 -0.980679643699123 29 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.375056107689238 -0.980679643699123 29 1 0.00869565217391304 115 7166 246074 Scd R-RNO-1296065 Inwardly rectifying K+ channels 0.375056107689238 -0.980679643699123 29 1 0.00869565217391304 115 7166 25743 Kcnj6 R-RNO-212718 EGFR interacts with phospholipase C-gamma 0.375056107689238 -0.980679643699123 29 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-1566948 Elastic fibre formation 0.375056107689238 -0.980679643699123 29 1 0.00869565217391304 115 7166 83727 Fbn1 R-RNO-5654687 Downstream signaling of activated FGFR1 0.375056107689238 -0.980679643699123 29 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-382551 Transmembrane transport of small molecules 0.381818993510917 -0.962808621649381 547 10 0.0869565217391304 115 7166 24546,140933,501925,689560,29707,24783,287715,266767,116638,24785 Slco2a1,Trpc5,Slc2a9,Ryr2,Gabra5,Slc9a2,Wnk4,Slc17a8,Slc17a7,Slc9a4 R-RNO-1236974 ER-Phagosome pathway 0.385125961639177 -0.954184825115025 30 1 0.00869565217391304 115 7166 365527 RT1-M6-2 R-RNO-196854 Metabolism of vitamins and cofactors 0.386556481783531 -0.95047728506357 139 3 0.0260869565217391 115 7166 24856,29527,287379 Ttr,Ptgs2,Shmt1 R-RNO-1280218 Adaptive Immune System 0.387421424919887 -0.948242225150535 490 9 0.0782608695652174 115 7166 365527,294269,311144,302934,313785,25599,309622,25443,294270 RT1-M6-2,RT1-Da,Itga4,Ppl,Icam5,Cd74,RT1-Bb,Fgf10,RT1-Db1 R-RNO-913709 O-linked glycosylation of mucins 0.41438045867812 -0.880970744848246 33 1 0.00869565217391304 115 7166 366061 Galnt3 R-RNO-451927 Interleukin-2 signaling 0.418810937403099 -0.870335684273529 205 4 0.0347826086956522 115 7166 293847,360573,25443,50646 Dusp9,Ksr1,Fgf10,Ptk2b R-RNO-75893 TNF signaling 0.423821962572666 -0.858441811525468 34 1 0.00869565217391304 115 7166 83537 Smpd2 R-RNO-1296071 Potassium Channels 0.425522648630326 -0.854437104111895 90 2 0.0173913043478261 115 7166 25743,307234 Kcnj6,Kcng2 R-RNO-4420097 VEGFA-VEGFR2 Pathway 0.428052966305471 -0.848508338006952 267 5 0.0434782608695652 115 7166 50646,25443,360573,295378,293847 Ptk2b,Fgf10,Ksr1,Vav3,Dusp9 R-RNO-168256 Immune System 0.432670368914306 -0.837779113610095 1364 23 0.2 115 7166 295378,24681,294270,311144,50646,24856,309622,25599,302934,360854,364867,116996,360573,259242,361422,500592,25443,313785,293847,29221,365527,54258,294269 Vav3,Prkcg,RT1-Db1,Itga4,Ptk2b,Ttr,RT1-Bb,Cd74,Ppl,Arpc5,Ticam2,Il16,Ksr1,Wipf3,Cotl1,Tnfrsf25,Fgf10,Icam5,Dusp9,Arg1,RT1-M6-2,Cxcr1,RT1-Da R-RNO-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.433112550669084 -0.83675765249502 35 1 0.00869565217391304 115 7166 365527 RT1-M6-2 R-RNO-5654741 Signaling by FGFR3 0.433112550669084 -0.83675765249502 35 1 0.00869565217391304 115 7166 366061 Galnt3 R-RNO-991365 Activation of GABAB receptors 0.433112550669084 -0.83675765249502 35 1 0.00869565217391304 115 7166 25743 Kcnj6 R-RNO-977444 GABA B receptor activation 0.433112550669084 -0.83675765249502 35 1 0.00869565217391304 115 7166 25743 Kcnj6 R-RNO-2871796 FCERI mediated MAPK activation 0.436904689697452 -0.82804020905294 210 4 0.0347826086956522 115 7166 25443,360573,295378,293847 Fgf10,Ksr1,Vav3,Dusp9 R-RNO-3928662 EPHB-mediated forward signaling 0.442254614429014 -0.815869512013603 36 1 0.00869565217391304 115 7166 360854 Arpc5 R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.442254614429014 -0.815869512013603 36 1 0.00869565217391304 115 7166 307234 Kcng2 R-RNO-163685 Integration of energy metabolism 0.44748641553415 -0.804109098076259 94 2 0.0173913043478261 115 7166 309242,307234 Gna14,Kcng2 R-RNO-1660662 Glycosphingolipid metabolism 0.451250507745597 -0.79573264413768 37 1 0.00869565217391304 115 7166 83537 Smpd2 R-RNO-196849 Metabolism of water-soluble vitamins and cofactors 0.452905085594518 -0.792072699526249 95 2 0.0173913043478261 115 7166 287379,29527 Shmt1,Ptgs2 R-RNO-73887 Death Receptor Signalling 0.460102547531093 -0.776305884928646 38 1 0.00869565217391304 115 7166 83537 Smpd2 R-RNO-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 0.460102547531093 -0.776305884928646 38 1 0.00869565217391304 115 7166 24443 Hdc R-RNO-140877 Formation of Fibrin Clot (Clotting Cascade) 0.460102547531093 -0.776305884928646 38 1 0.00869565217391304 115 7166 306761 F12 R-RNO-975634 Retinoid metabolism and transport 0.460102547531093 -0.776305884928646 38 1 0.00869565217391304 115 7166 24856 Ttr R-RNO-3858494 Beta-catenin independent WNT signaling 0.463652373387755 -0.768620202827932 97 2 0.0173913043478261 115 7166 100360552,24681 Fzd7,Prkcg R-RNO-425397 Transport of vitamins, nucleosides, and related molecules 0.468813014279055 -0.757551280270497 39 1 0.00869565217391304 115 7166 24546 Slco2a1 R-RNO-1296072 Voltage gated Potassium channels 0.468813014279055 -0.757551280270497 39 1 0.00869565217391304 115 7166 307234 Kcng2 R-RNO-112043 PLC beta mediated events 0.477384152671922 -0.739433760701854 40 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.477384152671922 -0.739433760701854 40 1 0.00869565217391304 115 7166 24253 Cebpb R-RNO-2424491 DAP12 signaling 0.481728505806591 -0.730374589586831 284 5 0.0434782608695652 115 7166 25443,360573,24681,295378,293847 Fgf10,Ksr1,Prkcg,Vav3,Dusp9 R-RNO-1650814 Collagen biosynthesis and modifying enzymes 0.485818172105903 -0.721920856555618 41 1 0.00869565217391304 115 7166 305253 Adamts3 R-RNO-75105 Fatty Acyl-CoA Biosynthesis 0.485818172105903 -0.721920856555618 41 1 0.00869565217391304 115 7166 246074 Scd R-RNO-112040 G-protein mediated events 0.485818172105903 -0.721920856555618 41 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-5654736 Signaling by FGFR1 0.494117247220423 -0.704982447404038 42 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-5362517 Signaling by Retinoic Acid 0.494117247220423 -0.704982447404038 42 1 0.00869565217391304 115 7166 24188 Aldh1a1 R-RNO-1483206 Glycerophospholipid biosynthesis 0.500280364123904 -0.692586609461479 104 2 0.0173913043478261 115 7166 85311,691478 Pla1a,Cpne6 R-RNO-2172127 DAP12 interactions 0.500299642774213 -0.692548074511394 290 5 0.0434782608695652 115 7166 25443,360573,24681,295378,293847 Fgf10,Ksr1,Prkcg,Vav3,Dusp9 R-RNO-112310 Neurotransmitter Release Cycle 0.502283518494014 -0.688590540840887 43 1 0.00869565217391304 115 7166 116638 Slc17a7 R-RNO-186797 Signaling by PDGF 0.5094942510044 -0.674336709985766 293 5 0.0434782608695652 115 7166 445442,293847,24681,360573,25443 Thbs1,Dusp9,Prkcg,Ksr1,Fgf10 R-RNO-383280 Nuclear Receptor transcription pathway 0.518226043656869 -0.657343754191755 45 1 0.00869565217391304 115 7166 58853 Nr4a3 R-RNO-6806667 Metabolism of fat-soluble vitamins 0.518226043656869 -0.657343754191755 45 1 0.00869565217391304 115 7166 24856 Ttr R-RNO-5578775 Ion homeostasis 0.526006412275948 -0.642441875680048 46 1 0.00869565217391304 115 7166 689560 Ryr2 R-RNO-114604 GPVI-mediated activation cascade 0.541195406930286 -0.613974869546562 48 1 0.00869565217391304 115 7166 295378 Vav3 R-RNO-76005 Response to elevated platelet cytosolic Ca2+ 0.549777294782551 -0.598242001334465 114 2 0.0173913043478261 115 7166 445442,24681 Thbs1,Prkcg R-RNO-72187 mRNA 3'-end processing 0.555901772066366 -0.587163669284737 50 1 0.00869565217391304 115 7166 361859 Cdc40 R-RNO-6798695 Neutrophil degranulation 0.563110189521474 -0.574279951482206 439 7 0.0608695652173913 115 7166 364867,360854,361422,24856,29221,365527,54258 Ticam2,Arpc5,Cotl1,Ttr,Arg1,RT1-M6-2,Cxcr1 R-RNO-195258 RHO GTPase Effectors 0.578113933065888 -0.547984313703624 186 3 0.0260869565217391 115 7166 259242,360854,295661 Wipf3,Arpc5,Spc25 R-RNO-372790 Signaling by GPCR 0.579203972102782 -0.546100580021884 1272 20 0.173913043478261 115 7166 25443,29413,24473,293847,54258,309242,25324,310999,499194,295378,24681,293024,53949,84348,84022,360573,66024,25666,295401,314904 Fgf10,Adra1d,Htr1a,Dusp9,Cxcr1,Gna14,Htr4,Plekhg5,Nmb,Vav3,Prkcg,Akap13,Chrm5,Ackr3,Ghsr,Ksr1,Npy2r,Dgkg,Plppr4,Arhgef25 R-RNO-204005 COPII (Coat Protein 2) Mediated Vesicle Transport 0.583926959848808 -0.5379793727277 54 1 0.00869565217391304 115 7166 361705 Cnih2 R-RNO-418346 Platelet homeostasis 0.583926959848808 -0.5379793727277 54 1 0.00869565217391304 115 7166 309242 Gna14 R-RNO-211945 Phase 1 - Functionalization of compounds 0.591337503486399 -0.525368352686537 123 2 0.0173913043478261 115 7166 24188,25426 Aldh1a1,Cyp1b1 R-RNO-73857 RNA Polymerase II Transcription 0.59577734965843 -0.517888256111693 124 2 0.0173913043478261 115 7166 361859,501688 Cdc40,Lsm11 R-RNO-180336 SHC1 events in EGFR signaling 0.603393897758272 -0.505185065403654 193 3 0.0260869565217391 115 7166 25443,360573,293847 Fgf10,Ksr1,Dusp9 R-RNO-112412 SOS-mediated signalling 0.603393897758272 -0.505185065403654 193 3 0.0260869565217391 115 7166 25443,293847,360573 Fgf10,Dusp9,Ksr1 R-RNO-179812 GRB2 events in EGFR signaling 0.603393897758272 -0.505185065403654 193 3 0.0260869565217391 115 7166 293847,360573,25443 Dusp9,Ksr1,Fgf10 R-RNO-5673001 RAF/MAP kinase cascade 0.603393897758272 -0.505185065403654 193 3 0.0260869565217391 115 7166 25443,293847,360573 Fgf10,Dusp9,Ksr1 R-RNO-2980736 Peptide hormone metabolism 0.610198006220323 -0.493971774124894 58 1 0.00869565217391304 115 7166 301265 Pla2g7 R-RNO-5684996 MAPK1/MAPK3 signaling 0.617391848815333 -0.482251369438334 197 3 0.0260869565217391 115 7166 25443,293847,360573 Fgf10,Dusp9,Ksr1 R-RNO-2586552 Signaling by Leptin 0.620839656033643 -0.476682433233127 198 3 0.0260869565217391 115 7166 25443,360573,293847 Fgf10,Ksr1,Dusp9 R-RNO-72202 Transport of Mature Transcript to Cytoplasm 0.622710021737538 -0.473674323227235 60 1 0.00869565217391304 115 7166 361859 Cdc40 R-RNO-111885 Opioid Signalling 0.622710021737538 -0.473674323227235 60 1 0.00869565217391304 115 7166 24681 Prkcg R-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.622710021737538 -0.473674323227235 60 1 0.00869565217391304 115 7166 361859 Cdc40 R-RNO-912526 Interleukin receptor SHC signaling 0.627672807214056 -0.4657362559065 200 3 0.0260869565217391 115 7166 25443,293847,360573 Fgf10,Dusp9,Ksr1 R-RNO-75109 Triglyceride Biosynthesis 0.628815896707199 -0.463916757163802 61 1 0.00869565217391304 115 7166 246074 Scd R-RNO-375165 NCAM signaling for neurite out-growth 0.631058041213159 -0.460357437765927 201 3 0.0260869565217391 115 7166 360573,293847,25443 Ksr1,Dusp9,Fgf10 R-RNO-449147 Signaling by Interleukins 0.635222700922807 -0.453779631459207 337 5 0.0434782608695652 115 7166 25443,50646,293847,360573,116996 Fgf10,Ptk2b,Dusp9,Ksr1,Il16 R-RNO-5218921 VEGFR2 mediated cell proliferation 0.64438894792993 -0.439452778773123 205 3 0.0260869565217391 115 7166 293847,360573,25443 Dusp9,Ksr1,Fgf10 R-RNO-5654738 Signaling by FGFR2 0.646551916421809 -0.436101780171034 64 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-512988 Interleukin-3, 5 and GM-CSF signaling 0.663751540241306 -0.409847385914472 211 3 0.0260869565217391 115 7166 25443,360573,293847 Fgf10,Ksr1,Dusp9 R-RNO-186763 Downstream signal transduction 0.666419100018664 -0.405836527047644 281 4 0.0347826086956522 115 7166 24681,360573,293847,25443 Prkcg,Ksr1,Dusp9,Fgf10 R-RNO-8853659 RET signaling 0.666904416951963 -0.405108546255954 212 3 0.0260869565217391 115 7166 293847,360573,25443 Dusp9,Ksr1,Fgf10 R-RNO-177929 Signaling by EGFR 0.674614983358247 -0.393613145871554 284 4 0.0347826086956522 115 7166 25443,24681,360573,293847 Fgf10,Prkcg,Ksr1,Dusp9 R-RNO-1280215 Cytokine Signaling in Immune system 0.687423799832703 -0.374804292191219 426 6 0.0521739130434783 115 7166 25443,50646,500592,293847,360573,116996 Fgf10,Ptk2b,Tnfrsf25,Dusp9,Ksr1,Il16 R-RNO-109704 PI3K Cascade 0.689845539255928 -0.371287562601189 72 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-5683057 MAPK family signaling cascades 0.694324964582021 -0.36481517939227 221 3 0.0260869565217391 115 7166 293847,360573,25443 Dusp9,Ksr1,Fgf10 R-RNO-351202 Metabolism of polyamines 0.694873416757986 -0.364025584166957 73 1 0.00869565217391304 115 7166 29221 Arg1 R-RNO-211897 Cytochrome P450 - arranged by substrate type 0.694873416757986 -0.364025584166957 73 1 0.00869565217391304 115 7166 25426 Cyp1b1 R-RNO-388396 GPCR downstream signaling 0.697475910888111 -0.360287302244141 1029 15 0.130434782608696 115 7166 309242,314904,54258,25666,66024,84348,29413,84022,24473,293024,53949,25324,499194,310999,295378 Gna14,Arhgef25,Cxcr1,Dgkg,Npy2r,Ackr3,Adra1d,Ghsr,Htr1a,Akap13,Chrm5,Htr4,Nmb,Plekhg5,Vav3 R-RNO-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.69982048529387 -0.356931426407734 74 1 0.00869565217391304 115 7166 311169 Rtn4rl2 R-RNO-428157 Sphingolipid metabolism 0.69982048529387 -0.356931426407734 74 1 0.00869565217391304 115 7166 83537 Smpd2 R-RNO-2454202 Fc epsilon receptor (FCERI) signaling 0.703486563897734 -0.351706501547204 295 4 0.0347826086956522 115 7166 25443,295378,360573,293847 Fgf10,Vav3,Ksr1,Dusp9 R-RNO-2187338 Visual phototransduction 0.714189611334962 -0.336606789804139 77 1 0.00869565217391304 115 7166 24856 Ttr R-RNO-1236975 Antigen processing-Cross presentation 0.723388053011789 -0.323809474651953 79 1 0.00869565217391304 115 7166 365527 RT1-M6-2 R-RNO-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.727876605837226 -0.31762374262811 80 1 0.00869565217391304 115 7166 54315 Ucp2 R-RNO-166016 Toll Like Receptor 4 (TLR4) Cascade 0.727876605837226 -0.31762374262811 80 1 0.00869565217391304 115 7166 364867 Ticam2 R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.727876605837226 -0.31762374262811 80 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-2500257 Resolution of Sister Chromatid Cohesion 0.732292946558643 -0.311574644862848 81 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-1483257 Phospholipid metabolism 0.735437977037857 -0.3072890701132 161 2 0.0173913043478261 115 7166 85311,691478 Pla1a,Cpne6 R-RNO-112399 IRS-mediated signalling 0.74146843082049 -0.299122693063698 238 3 0.0260869565217391 115 7166 25443,360573,293847 Fgf10,Ksr1,Dusp9 R-RNO-199418 Negative regulation of the PI3K/AKT network 0.745120122535646 -0.294209835297195 84 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-2428928 IRS-related events triggered by IGF1R 0.749168103498126 -0.288791883400025 241 3 0.0260869565217391 115 7166 360573,293847,25443 Ksr1,Dusp9,Fgf10 R-RNO-2428924 IGF1R signaling cascade 0.749168103498126 -0.288791883400025 241 3 0.0260869565217391 115 7166 25443,293847,360573 Fgf10,Dusp9,Ksr1 R-RNO-5663220 RHO GTPases Activate Formins 0.749258951384589 -0.288670625730153 85 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-5668541 TNFR2 non-canonical NF-kB pathway 0.749258951384589 -0.288670625730153 85 1 0.00869565217391304 115 7166 500592 Tnfrsf25 R-RNO-74751 Insulin receptor signalling cascade 0.751694136664242 -0.285425770929917 242 3 0.0260869565217391 115 7166 293847,360573,25443 Dusp9,Ksr1,Fgf10 R-RNO-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.751694136664242 -0.285425770929917 242 3 0.0260869565217391 115 7166 360573,293847,25443 Ksr1,Dusp9,Fgf10 R-RNO-68877 Mitotic Prometaphase 0.753331147483776 -0.283250376958333 86 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.757337774332499 -0.27794592383102 87 1 0.00869565217391304 115 7166 501925 Slc2a9 R-RNO-556833 Metabolism of lipids and lipoproteins 0.766245229816932 -0.266253017112356 605 8 0.0695652173913043 115 7166 25426,29527,85311,691478,79242,305150,246074,83537 Cyp1b1,Ptgs2,Pla1a,Cpne6,Hpgd,Hsd17b13,Scd,Smpd2 R-RNO-73923 Lipid digestion, mobilization, and transport 0.783634088217188 -0.243813091794146 94 1 0.00869565217391304 115 7166 305150 Hsd17b13 R-RNO-74752 Signaling by Insulin receptor 0.802304783150158 -0.220266714442769 264 3 0.0260869565217391 115 7166 25443,360573,293847 Fgf10,Ksr1,Dusp9 R-RNO-1433557 Signaling by SCF-KIT 0.804387418803659 -0.21767426167878 265 3 0.0260869565217391 115 7166 25443,293847,360573 Fgf10,Dusp9,Ksr1 R-RNO-168249 Innate Immune System 0.808419202126564 -0.212674540485686 979 13 0.11304347826087 115 7166 361422,295378,24681,25443,24856,360573,259242,360854,364867,293847,365527,29221,54258 Cotl1,Vav3,Prkcg,Fgf10,Ttr,Ksr1,Wipf3,Arpc5,Ticam2,Dusp9,RT1-M6-2,Arg1,Cxcr1 R-RNO-2559583 Cellular Senescence 0.810242737548574 -0.210421400223638 102 1 0.00869565217391304 115 7166 24253 Cebpb R-RNO-8856828 Clathrin-mediated endocytosis 0.810242737548574 -0.210421400223638 102 1 0.00869565217391304 115 7166 360854 Arpc5 R-RNO-1257604 PIP3 activates AKT signaling 0.822303536714479 -0.195645686011886 106 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-199977 ER to Golgi Anterograde Transport 0.822303536714479 -0.195645686011886 106 1 0.00869565217391304 115 7166 361705 Cnih2 R-RNO-180292 GAB1 signalosome 0.830847517996538 -0.185308993145704 109 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-114608 Platelet degranulation 0.830847517996538 -0.185308993145704 109 1 0.00869565217391304 115 7166 445442 Thbs1 R-RNO-418555 G alpha (s) signalling events 0.830847517996538 -0.185308993145704 109 1 0.00869565217391304 115 7166 25324 Htr4 R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.833604005947194 -0.181996802395741 110 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-211859 Biological oxidations 0.83635900258094 -0.178697329151078 200 2 0.0173913043478261 115 7166 24188,25426 Aldh1a1,Cyp1b1 R-RNO-168898 Toll-Like Receptors Cascades 0.838984089874392 -0.175563535895697 112 1 0.00869565217391304 115 7166 364867 Ticam2 R-RNO-1430728 Metabolism 0.856520516540262 -0.154877007575767 1635 22 0.191304347826087 115 7166 290277,24443,291770,307234,24856,287379,691478,24188,79242,81718,29221,305150,309242,246074,83537,117108,85311,25426,29527,685325,64544,54315 Cryl1,Hdc,Chst9,Kcng2,Ttr,Shmt1,Cpne6,Aldh1a1,Hpgd,Cdo1,Arg1,Hsd17b13,Gna14,Scd,Smpd2,B3gat1,Pla1a,Cyp1b1,Ptgs2,Ddo,B3gat2,Ucp2 R-RNO-535734 Fatty acid, triacylglycerol, and ketone body metabolism 0.865634315356948 -0.144292728241148 123 1 0.00869565217391304 115 7166 246074 Scd R-RNO-201681 TCF dependent signaling in response to WNT 0.865634315356948 -0.144292728241148 123 1 0.00869565217391304 115 7166 500863 Rspo2 R-RNO-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.867828274433939 -0.141761424408698 124 1 0.00869565217391304 115 7166 54315 Ucp2 R-RNO-948021 Transport to the Golgi and subsequent modification 0.886042169373975 -0.120990734279453 133 1 0.00869565217391304 115 7166 361705 Cnih2 R-RNO-2467813 Separation of Sister Chromatids 0.896778917560266 -0.108945916019399 139 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-68882 Mitotic Anaphase 0.906512050913403 -0.0981509549832578 145 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-2555396 Mitotic Metaphase and Anaphase 0.908043330526857 -0.0964631806748906 146 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-72163 mRNA Splicing - Major Pathway 0.915334636069856 -0.0884655580860643 151 1 0.00869565217391304 115 7166 361859 Cdc40 R-RNO-72172 mRNA Splicing 0.923331178763145 -0.0797673019411033 157 1 0.00869565217391304 115 7166 361859 Cdc40 R-RNO-983169 Class I MHC mediated antigen processing & presentation 0.927043945036716 -0.0757543088907933 160 1 0.00869565217391304 115 7166 365527 RT1-M6-2 R-RNO-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.935028271272413 -0.0671785134955817 167 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-983705 Signaling by the B Cell Receptor (BCR) 0.951799317892309 -0.0494010669456163 185 1 0.00869565217391304 115 7166 25443 Fgf10 R-RNO-72203 Processing of Capped Intron-Containing Pre-mRNA 0.961167808063577 -0.0396062670835261 198 1 0.00869565217391304 115 7166 361859 Cdc40 R-RNO-68886 M Phase 0.962439095749296 -0.038284491965869 200 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-446203 Asparagine N-linked glycosylation 0.976057406043325 -0.0242338766313941 227 1 0.00869565217391304 115 7166 361705 Cnih2 R-RNO-199991 Membrane Trafficking 0.989554381019717 -0.0105005573701041 398 2 0.0173913043478261 115 7166 360854,361705 Arpc5,Cnih2 R-RNO-2262752 Cellular responses to stress 0.992856848437515 -0.00716878601641132 299 1 0.00869565217391304 115 7166 24253 Cebpb R-RNO-5653656 Vesicle-mediated transport 0.993119570100272 -0.0069042091948159 426 2 0.0173913043478261 115 7166 360854,361705 Arpc5,Cnih2 R-RNO-212436 Generic Transcription Pathway 0.994992322934858 -0.00502025749666876 320 1 0.00869565217391304 115 7166 58853 Nr4a3 R-RNO-597592 Post-translational protein modification 0.996273704058746 -0.00373325587720874 679 4 0.0347826086956522 115 7166 445442,311169,361705,366061 Thbs1,Rtn4rl2,Cnih2,Galnt3 R-RNO-392499 Metabolism of proteins 0.997338270451573 -0.00266527824904135 894 6 0.0521739130434783 115 7166 313262,301265,366061,361705,311169,445442 Pappa1,Pla2g7,Galnt3,Cnih2,Rtn4rl2,Thbs1 R-RNO-69278 Cell Cycle, Mitotic 0.997547028369942 -0.00245598509393641 362 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-1640170 Cell Cycle 0.999026477646859 -0.000973996533802713 416 1 0.00869565217391304 115 7166 295661 Spc25 R-RNO-74160 Gene Expression 0.999967286950612 -3.27135844717374e-05 889 3 0.0260869565217391 115 7166 501688,58853,361859 Lsm11,Nr4a3,Cdc40 R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin 0.999999999991852 -8.14833790421305e-12 60 0 0 115 7166 R-RNO-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.999999999991852 -8.14833790421305e-12 60 0 0 115 7166 R-RNO-446652 Interleukin-1 signaling 0.999999999992795 -7.20545037827677e-12 39 0 0 115 7166 R-RNO-72702 Ribosomal scanning and start codon recognition 0.999999999992795 -7.20545037827677e-12 39 0 0 115 7166 R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.999999999992795 -7.20545037827677e-12 39 0 0 115 7166 R-RNO-73762 RNA Polymerase I Transcription Initiation 0.999999999992795 -7.20545037827677e-12 39 0 0 115 7166 R-RNO-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.999999999992795 -7.20545037827677e-12 39 0 0 115 7166 R-RNO-5654708 Downstream signaling of activated FGFR3 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-6783589 Interleukin-6 family signaling 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-5654732 Negative regulation of FGFR3 signaling 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-73848 Pyrimidine metabolism 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-180786 Extension of Telomeres 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-70614 Amino acid synthesis and interconversion (transamination) 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-354192 Integrin alphaIIb beta3 signaling 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-174800 Chylomicron-mediated lipid transport 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-6803529 FGFR2 alternative splicing 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-157118 Signaling by NOTCH 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-418360 Platelet calcium homeostasis 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.999999999993239 -6.76074220670055e-12 24 0 0 115 7166 R-RNO-936440 Negative regulators of RIG-I/MDA5 signaling 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-1296346 Tandem pore domain potassium channels 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-1980148 Signaling by NOTCH3 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-193692 Regulated proteolysis of p75NTR 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-190828 Gap junction trafficking 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-450341 Activation of the AP-1 family of transcription factors 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-198323 AKT phosphorylates targets in the cytosol 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-211935 Fatty acids 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-71182 Phenylalanine and tyrosine catabolism 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-549132 Organic cation/anion/zwitterion transport 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-5250941 Negative epigenetic regulation of rRNA expression 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-73728 RNA Polymerase I Promoter Opening 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-419812 Calcitonin-like ligand receptors 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-844456 The NLRP3 inflammasome 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-189451 Heme biosynthesis 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-2022923 Dermatan sulfate biosynthesis 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-174414 Processive synthesis on the C-strand of the telomere 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-380320 Recruitment of NuMA to mitotic centrosomes 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-1980150 Signaling by NOTCH4 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-73614 Pyrimidine salvage reactions 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-194002 Glucocorticoid biosynthesis 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-2022377 Metabolism of Angiotensinogen to Angiotensins 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-418885 DCC mediated attractive signaling 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-432047 Passive transport by Aquaporins 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-8851805 MET activates RAS signaling 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-71240 Tryptophan catabolism 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-5686938 Regulation of TLR by endogenous ligand 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-425381 Bicarbonate transporters 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-74749 Signal attenuation 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-430116 GP1b-IX-V activation signalling 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-199220 Vitamin B5 (pantothenate) metabolism 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-391908 Prostanoid ligand receptors 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-112308 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels 0.999999999994349 -5.65110389939117e-12 10 0 0 115 7166 R-RNO-68962 Activation of the pre-replicative complex 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-1222556 ROS, RNS production in phagocytes 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-6806003 Regulation of TP53 Expression and Degradation 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-5693579 Homologous DNA Pairing and Strand Exchange 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-982772 Growth hormone receptor signaling 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-397795 G-protein beta:gamma signalling 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-6804757 Regulation of TP53 Degradation 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-4086398 Ca2+ pathway 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-113418 Formation of the Early Elongation Complex 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-73933 Resolution of Abasic Sites (AP sites) 0.999999999994401 -5.59862950327524e-12 29 0 0 115 7166 R-RNO-1980143 Signaling by NOTCH1 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-5218900 CASP8 activity is inhibited 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-8875656 MET receptor recycling 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-174437 Removal of the Flap Intermediate from the C-strand 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-1660517 Synthesis of PIPs at the late endosome membrane 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-5685939 HDR through MMEJ (alt-NHEJ) 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-3000480 Scavenging by Class A Receptors 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-2428933 SHC-related events triggered by IGF1R 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-977068 Termination of O-glycan biosynthesis 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-171306 Packaging Of Telomere Ends 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-74259 Purine catabolism 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-376176 Signaling by Robo receptor 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-2022857 Keratan sulfate degradation 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-5620922 BBSome-mediated cargo-targeting to cilium 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-193993 Mineralocorticoid biosynthesis 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-3232118 SUMOylation of transcription factors 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-69416 Dimerization of procaspase-8 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-1296052 Ca2+ activated K+ channels 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-390471 Association of TriC/CCT with target proteins during biosynthesis 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-389887 Beta-oxidation of pristanoyl-CoA 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-1059683 Interleukin-6 signaling 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-209822 Glycoprotein hormones 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-73929 Base-Excision Repair, AP Site Formation 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-74182 Ketone body metabolism 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-937039 IRAK1 recruits IKK complex 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-3371378 Regulation by c-FLIP 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-8876725 Protein methylation 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-420029 Tight junction interactions 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-140534 Ligand-dependent caspase activation 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-2468052 Establishment of Sister Chromatid Cohesion 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-376172 DSCAM interactions 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-6804759 Regulation of TP53 Activity through Association with Co-factors 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-427359 SIRT1 negatively regulates rRNA Expression 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-381070 IRE1alpha activates chaperones 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-975578 Reactions specific to the complex N-glycan synthesis pathway 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-8875555 MET activates RAP1 and RAC1 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-4419969 Depolymerisation of the Nuclear Lamina 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-1663150 The activation of arylsulfatases 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-196780 Biotin transport and metabolism 0.999999999994528 -5.47181905635623e-12 9 0 0 115 7166 R-RNO-390466 Chaperonin-mediated protein folding 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-8854214 TBC/RABGAPs 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-4085001 Sialic acid metabolism 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-1592389 Activation of Matrix Metalloproteinases 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-1170546 Prolactin receptor signaling 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-390918 Peroxisomal lipid metabolism 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-211981 Xenobiotics 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-445355 Smooth Muscle Contraction 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-391251 Protein folding 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-5625740 RHO GTPases activate PKNs 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-1638074 Keratan sulfate/keratin metabolism 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-5693607 Processing of DNA double-strand break ends 0.999999999994997 -5.00261713785209e-12 28 0 0 115 7166 R-RNO-1483249 Inositol phosphate metabolism 0.999999999995186 -4.81406077991227e-12 42 0 0 115 7166 R-RNO-8852135 Protein ubiquitination 0.999999999995186 -4.81406077991227e-12 42 0 0 115 7166 R-RNO-72165 mRNA Splicing - Minor Pathway 0.999999999995186 -4.81406077991227e-12 42 0 0 115 7166 R-RNO-445717 Aquaporin-mediated transport 0.999999999995186 -4.81406077991227e-12 42 0 0 115 7166 R-RNO-1660499 Synthesis of PIPs at the plasma membrane 0.999999999995186 -4.81406077991227e-12 42 0 0 115 7166 R-RNO-936837 Ion transport by P-type ATPases 0.999999999995186 -4.81406077991227e-12 42 0 0 115 7166 R-RNO-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.999999999996994 -3.00566776751011e-12 40 0 0 115 7166 R-RNO-73893 DNA Damage Bypass 0.999999999996994 -3.00566776751011e-12 40 0 0 115 7166 R-RNO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 0.999999999996994 -3.00566776751011e-12 40 0 0 115 7166 R-RNO-917937 Iron uptake and transport 0.999999999996994 -3.00566776751011e-12 40 0 0 115 7166 R-RNO-937072 TRAF6 mediated induction of TAK1 complex 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1855191 Synthesis of IPs in the nucleus 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-6807047 Cholesterol biosynthesis via desmosterol 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-176974 Unwinding of DNA 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-561048 Organic anion transport 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-111932 CaMK IV-mediated phosphorylation of CREB 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-447115 Interleukin-12 signaling 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-6803544 Ion influx/efflux at host-pathogen interface 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-419771 Opsins 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-418217 G beta:gamma signalling through PLC beta 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-390650 Histamine receptors 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-163765 ChREBP activates metabolic gene expression 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-204626 Hypusine synthesis from eIF5A-lysine 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-2161541 Abacavir metabolism 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-75944 Transcription from mitochondrial promoters 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1306955 GRB7 events in ERBB2 signaling 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-189085 Digestion of dietary carbohydrate 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-111957 Cam-PDE 1 activation 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1296025 ATP sensitive Potassium channels 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-6807062 Cholesterol biosynthesis via lathosterol 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-6783984 Glycine degradation 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-918233 TRAF3-dependent IRF activation pathway 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1237112 Methionine salvage pathway 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-446205 Synthesis of GDP-mannose 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-5676934 Protein repair 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-2473224 Antagonism of Activin by Follistatin 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1296053 Classical Kir channels 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-351906 Apoptotic cleavage of cell adhesion proteins 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-75157 FasL/ CD95L signaling 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-8875513 MET interacts with TNS proteins 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-5662702 Melanin biosynthesis 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1483115 Hydrolysis of LPC 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-8849474 PTK6 Activates STAT3 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-75072 mRNA Editing 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-427975 Proton/oligopeptide cotransporters 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-140179 Amine Oxidase reactions 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-165158 Activation of AKT2 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-69478 G2/M DNA replication checkpoint 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-71032 Propionyl-CoA catabolism 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-6799990 Metal sequestration by antimicrobial proteins 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1300642 Sperm Motility And Taxes 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-888593 Reuptake of GABA 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-75158 TRAIL signaling 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-8853383 Lysosomal oligosaccharide catabolism 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-209905 Catecholamine biosynthesis 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-110381 Resolution of AP sites via the single-nucleotide replacement pathway 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-70688 Proline catabolism 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-5632681 Ligand-receptor interactions 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-2243919 Crosslinking of collagen fibrils 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-1483226 Synthesis of PI 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-8849470 PTK6 Regulates Cell Cycle 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-447043 Neurofascin interactions 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-190861 Gap junction assembly 0.999999999997402 -2.5984281474949e-12 4 0 0 115 7166 R-RNO-5358346 Hedgehog ligand biogenesis 0.999999999997609 -2.3905746303961e-12 52 0 0 115 7166 R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.999999999997609 -2.3905746303961e-12 52 0 0 115 7166 R-RNO-73886 Chromosome Maintenance 0.999999999997609 -2.3905746303961e-12 52 0 0 115 7166 R-RNO-69473 G2/M DNA damage checkpoint 0.999999999997609 -2.3905746303961e-12 52 0 0 115 7166 R-RNO-8848021 Signaling by PTK6 0.999999999997609 -2.3905746303961e-12 52 0 0 115 7166 R-RNO-211000 Gene Silencing by RNA 0.999999999997609 -2.3905746303961e-12 52 0 0 115 7166 R-RNO-191859 snRNP Assembly 0.999999999997658 -2.34180795632515e-12 43 0 0 115 7166 R-RNO-194068 Bile acid and bile salt metabolism 0.999999999997658 -2.34180795632515e-12 43 0 0 115 7166 R-RNO-194441 Metabolism of non-coding RNA 0.999999999997658 -2.34180795632515e-12 43 0 0 115 7166 R-RNO-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.999999999997658 -2.34180795632515e-12 43 0 0 115 7166 R-RNO-190322 FGFR4 ligand binding and activation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-190375 FGFR2c ligand binding and activation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-170670 Adenylate cyclase inhibitory pathway 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-418359 Reduction of cytosolic Ca++ levels 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-389359 CD28 dependent Vav1 pathway 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-430039 mRNA decay by 5' to 3' exoribonuclease 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5654227 Phospholipase C-mediated cascade; FGFR3 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5213460 RIPK1-mediated regulated necrosis 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5668599 RHO GTPases Activate NADPH Oxidases 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-174411 Polymerase switching on the C-strand of the telomere 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5218859 Regulated Necrosis 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-111447 Activation of BAD and translocation to mitochondria 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-392517 Rap1 signalling 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-997269 Inhibition of adenylate cyclase pathway 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-68884 Mitotic Telophase/Cytokinesis 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-202040 G-protein activation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-69091 Polymerase switching 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-1369062 ABC transporters in lipid homeostasis 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-8874081 MET activates PTK2 signaling 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-202670 ERKs are inactivated 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-69109 Leading Strand Synthesis 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-1445148 Translocation of GLUT4 to the plasma membrane 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-139853 Elevation of cytosolic Ca2+ levels 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-156588 Glucuronidation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-975577 N-Glycan antennae elongation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-2024101 CS/DS degradation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-418597 G alpha (z) signalling events 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5633008 TP53 Regulates Transcription of Cell Death Genes 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-1295596 Spry regulation of FGF signaling 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-69166 Removal of the Flap Intermediate 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-2024096 HS-GAG degradation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-8866427 VLDLR internalisation and degradation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-1250347 SHC1 events in ERBB4 signaling 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-1502540 Signaling by Activin 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-157858 Gap junction trafficking and regulation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-189483 Heme degradation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-2046106 alpha-linolenic acid (ALA) metabolism 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-877312 Regulation of IFNG signaling 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-622312 Inflammasomes 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-1475029 Reversible hydration of carbon dioxide 0.999999999998358 -1.64217001971619e-12 12 0 0 115 7166 R-RNO-5693606 DNA Double Strand Break Response 0.999999999998473 -1.52672361775941e-12 41 0 0 115 7166 R-RNO-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-388479 Vasopressin-like receptors 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-199920 CREB phosphorylation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-196836 Vitamin C (ascorbate) metabolism 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-112311 Neurotransmitter Clearance In The Synaptic Cleft 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-190873 Gap junction degradation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-193634 Axonal growth inhibition (RHOA activation) 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-937042 IRAK2 mediated activation of TAK1 complex 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-3371511 HSF1 activation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-1834941 STING mediated induction of host immune responses 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-174430 Telomere C-strand synthesis initiation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-192456 Digestion of dietary lipid 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-196791 Vitamin D (calciferol) metabolism 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-426117 Cation-coupled Chloride cotransporters 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-3215018 Processing and activation of SUMO 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-140342 Apoptosis induced DNA fragmentation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-71336 Pentose phosphate pathway (hexose monophosphate shunt) 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-196025 Formation of annular gap junctions 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-1482883 Acyl chain remodeling of DAG and TAG 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-211227 Activation of DNA fragmentation factor 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-110329 Cleavage of the damaged pyrimidine 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-416550 Sema4D mediated inhibition of cell attachment and migration 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-73928 Depyrimidination 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-5357786 TNFR1-induced proapoptotic signaling 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-112411 MAPK1 (ERK2) activation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-427601 Multifunctional anion exchangers 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-198693 AKT phosphorylates targets in the nucleus 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-2161522 Abacavir transport and metabolism 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-429947 Deadenylation of mRNA 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-2046105 Linoleic acid (LA) metabolism 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-163767 PP2A-mediated dephosphorylation of key metabolic factors 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-68952 DNA replication initiation 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-162791 Attachment of GPI anchor to uPAR 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-111471 Apoptotic factor-mediated response 0.999999999998532 -1.46816004738312e-12 7 0 0 115 7166 R-RNO-6811440 Retrograde transport at the Trans-Golgi-Network 0.999999999998559 -1.44141877562509e-12 33 0 0 115 7166 R-RNO-157579 Telomere Maintenance 0.999999999998559 -1.44141877562509e-12 33 0 0 115 7166 R-RNO-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.999999999998559 -1.44141877562509e-12 33 0 0 115 7166 R-RNO-109606 Intrinsic Pathway for Apoptosis 0.999999999998559 -1.44141877562509e-12 33 0 0 115 7166 R-RNO-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 0.999999999998559 -1.44141877562509e-12 33 0 0 115 7166 R-RNO-1442490 Collagen degradation 0.999999999998559 -1.44141877562509e-12 33 0 0 115 7166 R-RNO-3214842 HDMs demethylate histones 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-1538133 G0 and Early G1 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-6804758 Regulation of TP53 Activity through Acetylation 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-499943 Synthesis and interconversion of nucleotide di- and triphosphates 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-191273 Cholesterol biosynthesis 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-180024 DARPP-32 events 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-425410 Metal ion SLC transporters 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-201451 Signaling by BMP 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-179409 APC-Cdc20 mediated degradation of Nek2A 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-1482788 Acyl chain remodelling of PC 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-8948216 Collagen chain trimerization 0.99999999999908 -9.20034766252556e-13 21 0 0 115 7166 R-RNO-69273 Cyclin A/B1 associated events during G2/M transition 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-166208 mTORC1-mediated signalling 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-1482839 Acyl chain remodelling of PE 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-2029485 Role of phospholipids in phagocytosis 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-203765 eNOS activation and regulation 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-140875 Common Pathway of Fibrin Clot Formation 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-5621575 CD209 (DC-SIGN) signaling 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-392154 Nitric oxide stimulates guanylate cyclase 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-8875878 MET promotes cell motility 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-5654712 FRS-mediated FGFR4 signaling 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-202131 Metabolism of nitric oxide 0.999999999999129 -8.71004297377561e-13 20 0 0 115 7166 R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.999999999999608 -3.92056710601679e-13 53 0 0 115 7166 R-RNO-1632852 Macroautophagy 0.999999999999608 -3.92056710601679e-13 53 0 0 115 7166 R-RNO-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.999999999999608 -3.92056710601679e-13 53 0 0 115 7166 R-RNO-5676590 NIK-->noncanonical NF-kB signaling 0.999999999999608 -3.92056710601679e-13 53 0 0 115 7166 R-RNO-5654716 Downstream signaling of activated FGFR4 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-5357905 Regulation of TNFR1 signaling 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-210991 Basigin interactions 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-5654733 Negative regulation of FGFR4 signaling 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-77387 Insulin receptor recycling 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-442742 CREB phosphorylation through the activation of Ras 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-2022854 Keratan sulfate biosynthesis 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-5656169 Termination of translesion DNA synthesis 0.999999999999949 -5.11069186373296e-14 25 0 0 115 7166 R-RNO-69229 Ubiquitin-dependent degradation of Cyclin D1 1.00000000000026 2.64440391715527e-13 46 0 0 115 7166 R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6 1.00000000000026 2.64440391715527e-13 46 0 0 115 7166 R-RNO-6799198 Complex I biogenesis 1.00000000000026 2.64440391715527e-13 46 0 0 115 7166 R-RNO-69610 p53-Independent DNA Damage Response 1.00000000000026 2.64440391715527e-13 46 0 0 115 7166 R-RNO-75815 Ubiquitin-dependent degradation of Cyclin D 1.00000000000026 2.64440391715527e-13 46 0 0 115 7166 R-RNO-69613 p53-Independent G1/S DNA damage checkpoint 1.00000000000026 2.64440391715527e-13 46 0 0 115 7166 R-RNO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 1.00000000000026 2.64440391715527e-13 46 0 0 115 7166 R-RNO-8854691 Interleukin-19, 20, 22, 24 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-8850843 Phosphate bond hydrolysis by NTPDase proteins 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-201688 WNT mediated activation of DVL 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-350054 Notch-HLH transcription pathway 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-196108 Pregnenolone biosynthesis 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-2485179 Activation of the phototransduction cascade 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-1187000 Fertilization 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-110056 MAPK3 (ERK1) activation 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-1474165 Reproduction 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-194313 VEGF ligand-receptor interactions 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-193144 Estrogen biosynthesis 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-163680 AMPK inhibits chREBP transcriptional activation activity 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-2393930 Phosphate bond hydrolysis by NUDT proteins 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-442380 Zinc influx into cells by the SLC39 gene family 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-2470946 Cohesin Loading onto Chromatin 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-2995410 Nuclear Envelope Reassembly 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-170660 Adenylate cyclase activating pathway 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-5576886 Phase 4 - resting membrane potential 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-1358803 Downregulation of ERBB2:ERBB3 signaling 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-381038 XBP1(S) activates chaperone genes 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-727802 Transport of nucleotide sugars 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-159740 Gamma-carboxylation of protein precursors 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-72731 Recycling of eIF2:GDP 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-8937144 Aryl hydrocarbon receptor signalling 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-1250342 PI3K events in ERBB4 signaling 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-110357 Displacement of DNA glycosylase by APEX1 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-427413 NoRC negatively regulates rRNA expression 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-448424 Interleukin-17 signaling 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-2179392 EGFR Transactivation by Gastrin 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-446210 Synthesis of UDP-N-acetyl-glucosamine 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-75108 Activation, myristolyation of BID and translocation to mitochondria 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-419037 NCAM1 interactions 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-195399 VEGF binds to VEGFR leading to receptor dimerization 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-75892 Platelet Adhesion to exposed collagen 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-2995383 Initiation of Nuclear Envelope Reformation 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-174403 Glutathione synthesis and recycling 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-1855167 Synthesis of pyrophosphates in the cytosol 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-209968 Thyroxine biosynthesis 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-77111 Synthesis of Ketone Bodies 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-203927 MicroRNA (miRNA) biogenesis 1.00000000000042 4.1662334952459e-13 8 0 0 115 7166 R-RNO-350864 Regulation of thyroid hormone activity 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-111448 Activation of NOXA and translocation to mitochondria 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-190827 Transport of connexins along the secretory pathway 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1299344 TWIK-related spinal cord K+ channel (TRESK) 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1483196 PI and PC transport between ER and Golgi membranes 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1369007 Mitochondrial ABC transporters 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-351143 Agmatine biosynthesis 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-177128 Conjugation of salicylate with glycine 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-156902 Peptide chain elongation 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1855231 Synthesis of IPs in the ER lumen 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-6804754 Regulation of TP53 Expression 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1300645 Acrosome Reaction 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-211994 Sterols are 12-hydroxylated by CYP8B1 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-163316 Mitochondrial transcription termination 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-165160 PDE3B signalling 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-6806664 Metabolism of vitamin K 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-975574 Reactions specific to the hybrid N-glycan synthesis pathway 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-211999 CYP2E1 reactions 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-5221030 TET1,2,3 and TDG demethylate DNA 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-389542 NADPH regeneration 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-379726 Mitochondrial tRNA aminoacylation 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-5263617 Metabolism of ingested MeSeO2H into MeSeH 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-2534343 Interaction With Cumulus Cells 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1299361 TWIK-related alkaline pH activated K+ channel (TALK) 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-181429 Serotonin Neurotransmitter Release Cycle 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1483076 Synthesis of CL 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-5690714 CD22 mediated BCR regulation 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-6814848 Glycerophospholipid catabolism 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-447038 NrCAM interactions 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-140180 COX reactions 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1483148 Synthesis of PG 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1483152 Hydrolysis of LPE 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-1606341 IRF3 mediated activation of type 1 IFN 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-2029481 FCGR activation 1.00000000000054 5.38374900216354e-13 1 0 0 115 7166 R-RNO-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-76046 RNA Polymerase III Transcription Initiation 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-6811438 Intra-Golgi traffic 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-69231 Cyclin D associated events in G1 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-5620920 Cargo trafficking to the periciliary membrane 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-5696400 Dual Incision in GG-NER 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-73884 Base Excision Repair 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-69236 G1 Phase 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-5696394 DNA Damage Recognition in GG-NER 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-1483166 Synthesis of PA 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-74158 RNA Polymerase III Transcription 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-111465 Apoptotic cleavage of cellular proteins 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-5696395 Formation of Incision Complex in GG-NER 1.00000000000055 5.48636084529391e-13 30 0 0 115 7166 R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21 1.00000000000055 5.54750367343289e-13 55 0 0 115 7166 R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs 1.00000000000055 5.54750367343289e-13 55 0 0 115 7166 R-RNO-201722 Formation of the beta-catenin:TCF transactivating complex 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-8855121 VLDL interactions 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-2129379 Molecules associated with elastic fibres 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-5693537 Resolution of D-Loop Structures 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-1169410 Antiviral mechanism by IFN-stimulated genes 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-70268 Pyruvate metabolism 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-1169408 ISG15 antiviral mechanism 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-5689896 Ovarian tumor domain proteases 1.00000000000084 8.37534827996805e-13 23 0 0 115 7166 R-RNO-5628897 TP53 Regulates Metabolic Genes 1.00000000000133 1.32788649020985e-12 44 0 0 115 7166 R-RNO-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 1.00000000000133 1.32788649020985e-12 44 0 0 115 7166 R-RNO-5685942 HDR through Homologous Recombination (HRR) 1.00000000000133 1.32788649020985e-12 44 0 0 115 7166 R-RNO-5578749 Transcriptional regulation by small RNAs 1.00000000000133 1.32788649020985e-12 44 0 0 115 7166 R-RNO-432722 Golgi Associated Vesicle Biogenesis 1.00000000000133 1.32788649020985e-12 44 0 0 115 7166 R-RNO-163359 Glucagon signaling in metabolic regulation 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-420092 Glucagon-type ligand receptors 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-113510 E2F mediated regulation of DNA replication 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-389356 CD28 co-stimulation 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-2514856 The phototransduction cascade 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-73863 RNA Polymerase I Transcription Termination 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-432720 Lysosome Vesicle Biogenesis 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-1483191 Synthesis of PC 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-73772 RNA Polymerase I Promoter Escape 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-70263 Gluconeogenesis 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-4570464 SUMOylation of RNA binding proteins 1.00000000000201 2.00802725273e-12 27 0 0 115 7166 R-RNO-5358508 Mismatch Repair 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-166663 Initial triggering of complement 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-5223345 Miscellaneous transport and binding events 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-70221 Glycogen breakdown (glycogenolysis) 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-6804760 Regulation of TP53 Activity through Methylation 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-1592230 Mitochondrial biogenesis 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-1660516 Synthesis of PIPs at the early endosome membrane 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-372708 p130Cas linkage to MAPK signaling for integrins 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-1482922 Acyl chain remodelling of PI 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-74217 Purine salvage 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-5654228 Phospholipase C-mediated cascade; FGFR4 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-1250196 SHC1 events in ERBB2 signaling 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-69183 Processive synthesis on the lagging strand 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-6785631 ERBB2 Regulates Cell Motility 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-418457 cGMP effects 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-69298 Association of licensing factors with the pre-replicative complex 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-435354 Zinc transporters 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-2173788 Downregulation of TGF-beta receptor signaling 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-162710 Synthesis of glycosylphosphatidylinositol (GPI) 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-6807004 Negative regulation of MET activity 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-2151201 Transcriptional activation of mitochondrial biogenesis 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-163615 PKA activation 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-5635838 Activation of SMO 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-164378 PKA activation in glucagon signalling 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-429958 mRNA decay by 3' to 5' exoribonuclease 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-8873719 RAB geranylgeranylation 1.00000000000229 2.28906879612172e-12 13 0 0 115 7166 R-RNO-69202 Cyclin E associated events during G1/S transition 1.00000000000233 2.32538309443685e-12 61 0 0 115 7166 R-RNO-69656 Cyclin A:Cdk2-associated events at S phase entry 1.00000000000233 2.32538309443685e-12 61 0 0 115 7166 R-RNO-611105 Respiratory electron transport 1.00000000000233 2.32538309443685e-12 61 0 0 115 7166 R-RNO-5658442 Regulation of RAS by GAPs 1.00000000000233 2.32538309443685e-12 61 0 0 115 7166 R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C 1.00000000000318 3.17767686528803e-12 56 0 0 115 7166 R-RNO-450294 MAP kinase activation in TLR cascade 1.00000000000318 3.17767686528803e-12 56 0 0 115 7166 R-RNO-421837 Clathrin derived vesicle budding 1.00000000000318 3.17767686528803e-12 56 0 0 115 7166 R-RNO-199992 trans-Golgi Network Vesicle Budding 1.00000000000318 3.17767686528803e-12 56 0 0 115 7166 R-RNO-3108214 SUMOylation of DNA damage response and repair proteins 1.00000000000318 3.17767686528803e-12 56 0 0 115 7166 R-RNO-6807505 RNA polymerase II transcribes snRNA genes 1.00000000000318 3.17767686528803e-12 56 0 0 115 7166 R-RNO-168138 Toll Like Receptor 9 (TLR9) Cascade 1.00000000000325 3.25054719891537e-12 80 0 0 115 7166 R-RNO-5419276 Mitochondrial translation termination 1.00000000000325 3.25054719891537e-12 80 0 0 115 7166 R-RNO-5689901 Metalloprotease DUBs 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-163210 Formation of ATP by chemiosmotic coupling 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-5205685 Pink/Parkin Mediated Mitophagy 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-983189 Kinesins 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-391903 Eicosanoid ligand-binding receptors 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-6785807 Interleukin-4 and 13 signaling 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-1480926 O2/CO2 exchange in erythrocytes 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-1660514 Synthesis of PIPs at the Golgi membrane 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-5656121 Translesion synthesis by POLI 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-5205647 Mitophagy 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-442729 CREB phosphorylation through the activation of CaMKII 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-2299718 Condensation of Prophase Chromosomes 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-438066 Unblocking of NMDA receptor, glutamate binding and activation 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-1606322 ZBP1(DAI) mediated induction of type I IFNs 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-2559585 Oncogene Induced Senescence 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-5655862 Translesion synthesis by POLK 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-1237044 Erythrocytes take up carbon dioxide and release oxygen 1.00000000000361 3.61332203622066e-12 15 0 0 115 7166 R-RNO-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 1.00000000000395 3.95118382895596e-12 118 0 0 115 7166 R-RNO-5357801 Programmed Cell Death 1.00000000000413 4.12644231614833e-12 81 0 0 115 7166 R-RNO-5368287 Mitochondrial translation 1.00000000000413 4.12644231614833e-12 81 0 0 115 7166 R-RNO-68875 Mitotic Prophase 1.00000000000447 4.47280842163732e-12 59 0 0 115 7166 R-RNO-69615 G1/S DNA Damage Checkpoints 1.00000000000447 4.47280842163732e-12 59 0 0 115 7166 R-RNO-380287 Centrosome maturation 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-69580 p53-Dependent G1/S DNA damage checkpoint 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-1483255 PI Metabolism 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-1799339 SRP-dependent cotranslational protein targeting to membrane 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-5693538 Homology Directed Repair 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-69563 p53-Dependent G1 DNA Damage Response 1.00000000000466 4.66395702733509e-12 58 0 0 115 7166 R-RNO-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-69186 Lagging Strand Synthesis 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-450302 activated TAK1 mediates p38 MAPK activation 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-442660 Na+/Cl- dependent neurotransmitter transporters 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-210993 Tie2 Signaling 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-2173789 TGF-beta receptor signaling activates SMADs 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-6788467 IL-6-type cytokine receptor ligand interactions 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-159418 Recycling of bile acids and salts 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-5683826 Surfactant metabolism 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-877300 Interferon gamma signaling 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-375170 CDO in myogenesis 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-171052 LDL-mediated lipid transport 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-212300 PRC2 methylates histones and DNA 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-5654720 PI-3K cascade:FGFR4 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-5654719 SHC-mediated cascade:FGFR4 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-194223 HDL-mediated lipid transport 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-5620916 VxPx cargo-targeting to cilium 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-525793 Myogenesis 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-75876 Synthesis of very long-chain fatty acyl-CoAs 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 1.00000000000468 4.67584004261217e-12 18 0 0 115 7166 R-RNO-75064 mRNA Editing: A to I Conversion 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-5661231 Metallothioneins bind metals 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-69560 Transcriptional activation of p53 responsive genes 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-190374 FGFR1c and Klotho ligand binding and activation 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-1307965 betaKlotho-mediated ligand binding 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-392851 Prostacyclin signalling through prostacyclin receptor 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-1614603 Cysteine formation from homocysteine 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-166020 Transfer of LPS from LBP carrier to CD14 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-379716 Cytosolic tRNA aminoacylation 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-141334 PAOs oxidise polyamines to amines 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-75102 C6 deamination of adenosine 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-203754 NOSIP mediated eNOS trafficking 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-3296197 Hydroxycarboxylic acid-binding receptors 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-381340 Transcriptional regulation of white adipocyte differentiation 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-171319 Telomere Extension By Telomerase 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-73943 Reversal of alkylation damage by DNA dioxygenases 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-916853 Degradation of GABA 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-5357572 Lysosomal glycogen catabolism 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-380612 Metabolism of serotonin 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-75094 Formation of the Editosome 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-429593 Inositol transporters 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-111452 Activation and oligomerization of BAK protein 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-1483101 Synthesis of PS 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-1300652 Sperm:Oocyte Membrane Binding 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-68881 Mitotic Metaphase/Anaphase Transition 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-111446 Activation of BIM and translocation to mitochondria 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-211163 AKT-mediated inactivation of FOXO1A 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-428559 Proton-coupled neutral amino acid transporters 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-210745 Regulation of gene expression in beta cells 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-451307 Activation of Na-permeable Kainate Receptors 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-72200 mRNA Editing: C to U Conversion 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-5362798 Release of Hh-Np from the secreting cell 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-198765 Signalling to ERK5 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-114294 Activation, translocation and oligomerization of BAX 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-169911 Regulation of Apoptosis 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-69895 Transcriptional activation of cell cycle inhibitor p21 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-5652227 Fructose biosynthesis 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-480985 Synthesis of dolichyl-phosphate-glucose 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-111457 Release of apoptotic factors from the mitochondria 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-190704 Oligomerization of connexins into connexons 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-452723 Transcriptional regulation of pluripotent stem cells 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-381042 PERK regulates gene expression 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-888568 GABA synthesis 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-379397 Enzymatic degradation of dopamine by COMT 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-432030 Transport of glycerol from adipocytes to the liver by Aquaporins 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-5660526 Response to metal ions 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-844455 The NLRP1 inflammasome 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-177162 Conjugation of phenylacetate with glutamine 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-141424 Amplification of signal from the kinetochores 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-8854521 Interaction between PHLDA1 and AURKA 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-75896 Plasmalogen biosynthesis 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-73942 DNA Damage Reversal 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-163358 PKA-mediated phosphorylation of key metabolic factors 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-8847453 Synthesis of PIPs in the nucleus 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-77042 Formation of editosomes by ADAR proteins 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-379398 Enzymatic degradation of Dopamine by monoamine oxidase 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-1299316 TWIK-releated acid-sensitive K+ channel (TASK) 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-190872 Transport of connexons to the plasma membrane 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-111995 phospho-PLA2 pathway 1.00000000000514 5.14215531049675e-12 2 0 0 115 7166 R-RNO-975576 N-glycan antennae elongation in the medial/trans-Golgi 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-5627123 RHO GTPases activate PAKs 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-2022928 HS-GAG biosynthesis 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-69190 DNA strand elongation 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-774815 Nucleosome assembly 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-6783310 Fanconi Anemia Pathway 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-168638 NOD1/2 Signaling Pathway 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-110314 Recognition of DNA damage by PCNA-containing replication complex 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-8863795 Downregulation of ERBB2 signaling 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-174417 Telomere C-strand (Lagging Strand) Synthesis 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-189445 Metabolism of porphyrins 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-198725 Nuclear Events (kinase and transcription factor activation) 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-606279 Deposition of new CENPA-containing nucleosomes at the centromere 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 1.00000000000534 5.34406255189836e-12 22 0 0 115 7166 R-RNO-6807878 COPI-mediated anterograde transport 1.00000000000576 5.76276272243175e-12 66 0 0 115 7166 R-RNO-1474228 Degradation of the extracellular matrix 1.00000000000576 5.76276272243175e-12 66 0 0 115 7166 R-RNO-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 1.00000000000576 5.76276272243175e-12 66 0 0 115 7166 R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition 1.00000000000576 5.76276272243175e-12 66 0 0 115 7166 R-RNO-68949 Orc1 removal from chromatin 1.00000000000576 5.76276272243175e-12 66 0 0 115 7166 R-RNO-69052 Switching of origins to a post-replicative state 1.00000000000576 5.76276272243175e-12 66 0 0 115 7166 R-RNO-4641257 Degradation of AXIN 1.00000000000576 5.76341908380592e-12 48 0 0 115 7166 R-RNO-350562 Regulation of ornithine decarboxylase (ODC) 1.00000000000576 5.76341908380592e-12 48 0 0 115 7166 R-RNO-73854 RNA Polymerase I Promoter Clearance 1.00000000000576 5.76341908380592e-12 48 0 0 115 7166 R-RNO-6806834 Signaling by MET 1.00000000000576 5.76341908380592e-12 48 0 0 115 7166 R-RNO-913531 Interferon Signaling 1.00000000000576 5.76341908380592e-12 48 0 0 115 7166 R-RNO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.00000000000576 5.76341908380592e-12 48 0 0 115 7166 R-RNO-174048 APC/C:Cdc20 mediated degradation of Cyclin B 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-437239 Recycling pathway of L1 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-198753 ERK/MAPK targets 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-901042 Calnexin/calreticulin cycle 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-69618 Mitotic Spindle Checkpoint 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-5357956 TNFR1-induced NFkappaB signaling pathway 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-5654706 FRS-mediated FGFR3 signaling 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-71403 Citric acid cycle (TCA cycle) 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-373752 Netrin-1 signaling 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-389513 CTLA4 inhibitory signaling 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-3371571 HSF1-dependent transactivation 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-1679131 Trafficking and processing of endosomal TLR 1.00000000000589 5.88605381200223e-12 19 0 0 115 7166 R-RNO-2168880 Scavenging of heme from plasma 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-69205 G1/S-Specific Transcription 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-8849932 SALM protein interactions at the synapses 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-209776 Amine-derived hormones 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-442982 Ras activation uopn Ca2+ infux through NMDA receptor 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-3928664 Ephrin signaling 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-1251985 Nuclear signaling by ERBB4 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-1482925 Acyl chain remodelling of PG 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-418038 Nucleotide-like (purinergic) receptors 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-373753 Nephrin interactions 1.00000000000629 6.29285963165447e-12 16 0 0 115 7166 R-RNO-2980766 Nuclear Envelope Breakdown 1.0000000000067 6.70389732822889e-12 36 0 0 115 7166 R-RNO-109703 PKB-mediated events 1.0000000000067 6.70389732822889e-12 36 0 0 115 7166 R-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins 1.0000000000067 6.70389732822889e-12 36 0 0 115 7166 R-RNO-2871837 FCERI mediated NF-kB activation 1.00000000000684 6.83819415929391e-12 64 0 0 115 7166 R-RNO-933542 TRAF6 mediated NF-kB activation 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-400685 Sema4D in semaphorin signaling 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-110312 Translesion synthesis by REV1 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-2408522 Selenoamino acid metabolism 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-111931 PKA-mediated phosphorylation of CREB 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-901032 ER Quality Control Compartment (ERQC) 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-1963642 PI3K events in ERBB2 signaling 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-196299 Beta-catenin phosphorylation cascade 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-2142845 Hyaluronan metabolism 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-912694 Regulation of IFNA signaling 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-204174 Regulation of pyruvate dehydrogenase (PDH) complex 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-381119 Unfolded Protein Response (UPR) 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-1810476 RIP-mediated NFkB activation via ZBP1 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-156581 Methylation 1.00000000000685 6.85072656541863e-12 14 0 0 115 7166 R-RNO-3299685 Detoxification of Reactive Oxygen Species 1.00000000000705 7.05031347133308e-12 31 0 0 115 7166 R-RNO-176187 Activation of ATR in response to replication stress 1.00000000000705 7.05031347133308e-12 31 0 0 115 7166 R-RNO-438064 Post NMDA receptor activation events 1.00000000000705 7.05031347133308e-12 31 0 0 115 7166 R-RNO-3214858 RMTs methylate histone arginines 1.00000000000705 7.05031347133308e-12 31 0 0 115 7166 R-RNO-352230 Amino acid transport across the plasma membrane 1.00000000000705 7.05031347133308e-12 31 0 0 115 7166 R-RNO-76009 Platelet Aggregation (Plug Formation) 1.00000000000705 7.05031347133308e-12 31 0 0 115 7166 R-RNO-70171 Glycolysis 1.00000000000705 7.05031347133308e-12 31 0 0 115 7166 R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.0000000000071 7.09983962397457e-12 54 0 0 115 7166 R-RNO-8854518 AURKA Activation by TPX2 1.0000000000071 7.09983962397457e-12 54 0 0 115 7166 R-RNO-68827 CDT1 association with the CDC6:ORC:origin complex 1.0000000000071 7.09983962397457e-12 54 0 0 115 7166 R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome 1.0000000000071 7.09983962397457e-12 54 0 0 115 7166 R-RNO-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.00000000000713 7.12837039535218e-12 47 0 0 115 7166 R-RNO-3371453 Regulation of HSF1-mediated heat shock response 1.00000000000713 7.12837039535218e-12 47 0 0 115 7166 R-RNO-375281 Hormone ligand-binding receptors 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-400508 Incretin synthesis, secretion, and inactivation 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-209952 Peptide hormone biosynthesis 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-1433559 Regulation of KIT signaling 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-3371568 Attenuation phase 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-171007 p38MAPK events 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-1483213 Synthesis of PE 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-8847993 ERBB2 Activates PTK6 Signaling 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-417957 P2Y receptors 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-3134975 Regulation of innate immune responses to cytosolic DNA 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-1963640 GRB2 events in ERBB2 signaling 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-622323 Presynaptic nicotinic acetylcholine receptors 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-73817 Purine ribonucleoside monophosphate biosynthesis 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-5626467 RHO GTPases activate IQGAPs 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-1855183 Synthesis of IP2, IP, and Ins in the cytosol 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-200425 Import of palmitoyl-CoA into the mitochondrial matrix 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-912631 Regulation of signaling by CBL 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-68689 CDC6 association with the ORC:origin complex 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-933541 TRAF6 mediated IRF7 activation 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-193048 Androgen biosynthesis 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-3322077 Glycogen synthesis 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-446353 Cell-extracellular matrix interactions 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-416572 Sema4D induced cell migration and growth-cone collapse 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-2160916 Hyaluronan uptake and degradation 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-5423646 Aflatoxin activation and detoxification 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-190373 FGFR1c ligand binding and activation 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-71064 Lysine catabolism 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-425561 Sodium/Calcium exchangers 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-3000170 Syndecan interactions 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-5607763 CLEC7A (Dectin-1) induces NFAT activation 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-1266695 Interleukin-7 signaling 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-1462054 Alpha-defensins 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-5675482 Regulation of necroptotic cell death 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-73621 Pyrimidine catabolism 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-203615 eNOS activation 1.00000000000715 7.15096180451951e-12 11 0 0 115 7166 R-RNO-73776 RNA Polymerase II Promoter Escape 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-1227986 Signaling by ERBB2 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-72649 Translation initiation complex formation 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-75153 Apoptotic execution phase 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-75953 RNA Polymerase II Transcription Initiation 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-1236394 Signaling by ERBB4 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-189200 Hexose transport 1.00000000000732 7.32433667530057e-12 38 0 0 115 7166 R-RNO-6781823 Formation of TC-NER Pre-Incision Complex 1.00000000000743 7.42975893895293e-12 45 0 0 115 7166 R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.00000000000743 7.42975893895293e-12 45 0 0 115 7166 R-RNO-1834949 Cytosolic sensors of pathogen-associated DNA 1.00000000000743 7.42975893895293e-12 45 0 0 115 7166 R-RNO-165159 mTOR signalling 1.00000000000804 8.04483537579249e-12 35 0 0 115 7166 R-RNO-70153 Glucose transport 1.00000000000804 8.04483537579249e-12 35 0 0 115 7166 R-RNO-5693571 Nonhomologous End-Joining (NHEJ) 1.00000000000804 8.04483537579249e-12 35 0 0 115 7166 R-RNO-166658 Complement cascade 1.00000000000804 8.04483537579249e-12 35 0 0 115 7166 R-RNO-5654743 Signaling by FGFR4 1.00000000000804 8.04483537579249e-12 35 0 0 115 7166 R-RNO-5693532 DNA Double-Strand Break Repair 1.00000000000814 8.13948550521286e-12 100 0 0 115 7166 R-RNO-109581 Apoptosis 1.00000000000817 8.17426109422579e-12 79 0 0 115 7166 R-RNO-5610787 Hedgehog 'off' state 1.00000000000817 8.17426109422579e-12 79 0 0 115 7166 R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.0000000000082 8.20055627527035e-12 65 0 0 115 7166 R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 1.0000000000082 8.20055627527035e-12 65 0 0 115 7166 R-RNO-174824 Lipoprotein metabolism 1.0000000000082 8.20055627527035e-12 65 0 0 115 7166 R-RNO-212676 Dopamine Neurotransmitter Release Cycle 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-549127 Organic cation transport 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-110362 POLB-Dependent Long Patch Base Excision Repair 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-3270619 IRF3-mediated induction of type I IFN 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-2142688 Synthesis of 5-eicosatetraenoic acids 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-8857538 PTK6 promotes HIF1A stabilization 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1980145 Signaling by NOTCH2 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-500753 Pyrimidine biosynthesis 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-390247 Beta-oxidation of very long chain fatty acids 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1912422 Pre-NOTCH Expression and Processing 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-196843 Vitamin B2 (riboflavin) metabolism 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-448706 Interleukin-1 processing 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-74713 IRS activation 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-4641265 Repression of WNT target genes 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-444821 Relaxin receptors 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-5358493 Synthesis of diphthamide-EEF2 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-5625900 RHO GTPases activate CIT 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-879415 Advanced glycosylation endproduct receptor signaling 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-392170 ADP signalling through P2Y purinoceptor 12 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-5693548 Sensing of DNA Double Strand Breaks 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-6806942 MET Receptor Activation 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-68616 Assembly of the ORC complex at the origin of replication 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-71288 Creatine metabolism 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-446199 Synthesis of Dolichyl-phosphate 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-176417 Phosphorylation of Emi1 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1362409 Mitochondrial iron-sulfur cluster biogenesis 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-629587 Highly sodium permeable acetylcholine nicotinic receptors 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-190371 FGFR3b ligand binding and activation 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-804914 Transport of fatty acids 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1461957 Beta defensins 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-6783783 Interleukin-10 signaling 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-68911 G2 Phase 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1912420 Pre-NOTCH Processing in Golgi 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-211958 Miscellaneous substrates 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-6787639 GDP-fucose biosynthesis 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-8851907 MET activates PI3K/AKT signaling 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-1253288 Downregulation of ERBB4 signaling 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-2214320 Anchoring fibril formation 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-426496 Post-transcriptional silencing by small RNAs 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-72764 Eukaryotic Translation Termination 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-6798163 Choline catabolism 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-444257 RSK activation 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-166665 Terminal pathway of complement 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-6811555 PI5P Regulates TP53 Acetylation 1.00000000000823 8.22581872530204e-12 6 0 0 115 7166 R-RNO-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1.00000000000868 8.67679883432428e-12 32 0 0 115 7166 R-RNO-429914 Deadenylation-dependent mRNA decay 1.00000000000868 8.67679883432428e-12 32 0 0 115 7166 R-RNO-196071 Metabolism of steroid hormones 1.00000000000868 8.67679883432428e-12 32 0 0 115 7166 R-RNO-192105 Synthesis of bile acids and bile salts 1.00000000000868 8.67679883432428e-12 32 0 0 115 7166 R-RNO-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 1.00000000000868 8.67679883432428e-12 32 0 0 115 7166 R-RNO-73847 Purine metabolism 1.00000000000868 8.67679883432428e-12 32 0 0 115 7166 R-RNO-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1.00000000000908 9.07722626368747e-12 72 0 0 115 7166 R-RNO-166054 Activated TLR4 signalling 1.00000000000908 9.07722626368747e-12 72 0 0 115 7166 R-RNO-927802 Nonsense-Mediated Decay (NMD) 1.00000000000908 9.07722626368747e-12 72 0 0 115 7166 R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation 1.00000000000908 9.07722626368747e-12 72 0 0 115 7166 R-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.00000000000908 9.07722626368747e-12 72 0 0 115 7166 R-RNO-5620912 Anchoring of the basal body to the plasma membrane 1.00000000000908 9.07722626368747e-12 72 0 0 115 7166 R-RNO-5358351 Signaling by Hedgehog 1.00000000000953 9.5284630061465e-12 104 0 0 115 7166 R-RNO-5621481 C-type lectin receptors (CLRs) 1.00000000000953 9.5284630061465e-12 104 0 0 115 7166 R-RNO-4608870 Asymmetric localization of PCP proteins 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-69541 Stabilization of p53 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-6803157 Antimicrobial peptides 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-373080 Class B/2 (Secretin family receptors) 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-2559580 Oxidative Stress Induced Senescence 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-73864 RNA Polymerase I Transcription 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-170834 Signaling by TGF-beta Receptor Complex 1.00000000001052 1.05171811840588e-11 50 0 0 115 7166 R-RNO-68874 M/G1 Transition 1.00000000001065 1.06471277172252e-11 77 0 0 115 7166 R-RNO-69002 DNA Replication Pre-Initiation 1.00000000001065 1.06471277172252e-11 77 0 0 115 7166 R-RNO-69481 G2/M Checkpoints 1.00000000001074 1.07399811370266e-11 117 0 0 115 7166 R-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-168176 Toll Like Receptor 5 (TLR5) Cascade 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-168179 Toll Like Receptor TLR1:TLR2 Cascade 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-3108232 SUMO E3 ligases SUMOylate target proteins 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-975871 MyD88 cascade initiated on plasma membrane 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-168188 Toll Like Receptor TLR6:TLR2 Cascade 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-181438 Toll Like Receptor 2 (TLR2) Cascade 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-166058 MyD88:Mal cascade initiated on plasma membrane 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-168142 Toll Like Receptor 10 (TLR10) Cascade 1.00000000001088 1.08767619890789e-11 70 0 0 115 7166 R-RNO-72766 Translation 1.00000000001119 1.11934417534005e-11 93 0 0 115 7166 R-RNO-5607764 CLEC7A (Dectin-1) signaling 1.00000000001124 1.12406631631952e-11 86 0 0 115 7166 R-RNO-382556 ABC-family proteins mediated transport 1.00000000001124 1.12406631631952e-11 86 0 0 115 7166 R-RNO-5633007 Regulation of TP53 Activity 1.00000000001142 1.14226324632682e-11 122 0 0 115 7166 R-RNO-1169091 Activation of NF-kappaB in B cells 1.00000000001202 1.20244571574116e-11 57 0 0 115 7166 R-RNO-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.00000000001202 1.20244571574116e-11 57 0 0 115 7166 R-RNO-446219 Synthesis of substrates in N-glycan biosythesis 1.00000000001202 1.20244571574116e-11 57 0 0 115 7166 R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation 1.00000000001234 1.23370595438596e-11 114 0 0 115 7166 R-RNO-69242 S Phase 1.00000000001234 1.23370595438596e-11 114 0 0 115 7166 R-RNO-3700989 Transcriptional Regulation by TP53 1.00000000001234 1.23380688469468e-11 226 0 0 115 7166 R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-917977 Transferrin endocytosis and recycling 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-390522 Striated Muscle Contraction 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-392451 G beta:gamma signalling through PI3Kgamma 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-977606 Regulation of Complement cascade 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-380972 Energy dependent regulation of mTOR by LKB1-AMPK 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-156590 Glutathione conjugation 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-5685938 HDR through Single Strand Annealing (SSA) 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-2514859 Inactivation, recovery and regulation of the phototransduction cascade 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-72086 mRNA Capping 1.00000000001254 1.2544129663711e-11 26 0 0 115 7166 R-RNO-390651 Dopamine receptors 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-112307 Transmission across Electrical Synapses 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-977347 Serine biosynthesis 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-174577 Activation of C3 and C5 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-435368 Zinc efflux and compartmentalization by the SLC30 family 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-75205 Dissolution of Fibrin Clot 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-417973 Adenosine P1 receptors 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-209931 Serotonin and melatonin biosynthesis 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-196819 Vitamin B1 (thiamin) metabolism 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-964739 N-glycan trimming and elongation in the cis-Golgi 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-1181150 Signaling by NODAL 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-2187335 The retinoid cycle in cones (daylight vision) 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-196783 Coenzyme A biosynthesis 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-203641 NOSTRIN mediated eNOS trafficking 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-426048 Arachidonate production from DAG 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-5578768 Physiological factors 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-111459 Activation of caspases through apoptosome-mediated cleavage 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-5576890 Phase 3 - rapid repolarisation 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-166786 Creation of C4 and C2 activators 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-1169092 Activation of RAS in B cells 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-2142712 Synthesis of 12-eicosatetraenoic acid derivatives 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-211979 Eicosanoids 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-3000471 Scavenging by Class B Receptors 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-380095 Tachykinin receptors bind tachykinins 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-2122947 NOTCH1 Intracellular Domain Regulates Transcription 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-947581 Molybdenum cofactor biosynthesis 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-428890 Role of Abl in Robo-Slit signaling 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-5674499 Negative feedback regulation of MAPK pathway 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-442720 CREB phosphorylation through the activation of Adenylate Cyclase 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-5689877 Josephin domain DUBs 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-173623 Classical antibody-mediated complement activation 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-5627117 RHO GTPases Activate ROCKs 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-1614517 Sulfide oxidation to sulfate 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-111461 Cytochrome c-mediated apoptotic response 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-5666185 RHO GTPases Activate Rhotekin and Rhophilins 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-8849468 PTK6 Regulates Proteins Involved in RNA Processing 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-174362 Transport and synthesis of PAPS 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-389599 Alpha-oxidation of phytanate 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-1566977 Fibronectin matrix formation 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-442717 CREB phosphorylation through the activation of CaMKK 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-112303 Electric Transmission Across Gap Junctions 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-500657 Presynaptic function of Kainate receptors 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-156711 Polo-like kinase mediated events 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-8866376 Reelin signalling pathway 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-5625970 RHO GTPases activate KTN1 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-211916 Vitamins 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-8935690 Miscellaneous digestion events 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-8865999 MET activates PTPN11 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-433692 Proton-coupled monocarboxylate transport 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-70370 Galactose catabolism 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-140834 Extrinsic Pathway of Fibrin Clot Formation 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-2514853 Condensation of Prometaphase Chromosomes 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-1482798 Acyl chain remodeling of CL 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-427652 Sodium-coupled phosphate cotransporters 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-8866423 VLDL biosynthesis 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-391906 Leukotriene receptors 1.00000000001261 1.2613655788613e-11 5 0 0 115 7166 R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 1.00000000001327 1.32667654909448e-11 49 0 0 115 7166 R-RNO-212165 Epigenetic regulation of gene expression 1.00000000001327 1.32667654909448e-11 49 0 0 115 7166 R-RNO-70326 Glucose metabolism 1.00000000001333 1.33342004452935e-11 67 0 0 115 7166 R-RNO-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 1.00000000001333 1.33342004452935e-11 67 0 0 115 7166 R-RNO-5689603 UCH proteinases 1.00000000001333 1.33342004452935e-11 67 0 0 115 7166 R-RNO-5688426 Deubiquitination 1.00000000001349 1.34874148095348e-11 183 0 0 115 7166 R-RNO-4641258 Degradation of DVL 1.00000000001353 1.35337563726141e-11 51 0 0 115 7166 R-RNO-6782135 Dual incision in TC-NER 1.00000000001353 1.35337563726141e-11 51 0 0 115 7166 R-RNO-5610780 Degradation of GLI1 by the proteasome 1.00000000001353 1.35337563726141e-11 51 0 0 115 7166 R-RNO-380259 Loss of Nlp from mitotic centrosomes 1.00000000001353 1.35337563726141e-11 51 0 0 115 7166 R-RNO-75955 RNA Polymerase II Transcription Elongation 1.00000000001353 1.35337563726141e-11 51 0 0 115 7166 R-RNO-380284 Loss of proteins required for interphase microtubule organization from the centrosome 1.00000000001353 1.35337563726141e-11 51 0 0 115 7166 R-RNO-112382 Formation of RNA Pol II elongation complex 1.00000000001353 1.35337563726141e-11 51 0 0 115 7166 R-RNO-3214841 PKMTs methylate histone lysines 1.00000000001362 1.36165313798612e-11 37 0 0 115 7166 R-RNO-1660661 Sphingolipid de novo biosynthesis 1.00000000001362 1.36165313798612e-11 37 0 0 115 7166 R-RNO-975155 MyD88 dependent cascade initiated on endosome 1.00000000001384 1.38388275306941e-11 76 0 0 115 7166 R-RNO-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1.00000000001384 1.38388275306941e-11 76 0 0 115 7166 R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis 1.00000000001384 1.38388275306941e-11 76 0 0 115 7166 R-RNO-2262749 Cellular response to hypoxia 1.00000000001437 1.4374451062775e-11 62 0 0 115 7166 R-RNO-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1.00000000001437 1.4374451062775e-11 62 0 0 115 7166 R-RNO-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 1.00000000001437 1.4374451062775e-11 62 0 0 115 7166 R-RNO-5696398 Nucleotide Excision Repair 1.00000000001538 1.53772663685867e-11 84 0 0 115 7166 R-RNO-5620924 Intraflagellar transport 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-3769402 Deactivation of the beta-catenin transactivating complex 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-3214847 HATs acetylate histones 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-5250913 Positive epigenetic regulation of rRNA expression 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-5250924 B-WICH complex positively regulates rRNA expression 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-4615885 SUMOylation of DNA replication proteins 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-73777 RNA Polymerase I Chain Elongation 1.00000000001548 1.5483470929875e-11 34 0 0 115 7166 R-RNO-5632684 Hedgehog 'on' state 1.0000000000158 1.57977660853866e-11 71 0 0 115 7166 R-RNO-156827 L13a-mediated translational silencing of Ceruloplasmin expression 1.0000000000158 1.57977660853866e-11 71 0 0 115 7166 R-RNO-69304 Regulation of DNA replication 1.0000000000158 1.57977660853866e-11 71 0 0 115 7166 R-RNO-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 1.0000000000158 1.57977660853866e-11 71 0 0 115 7166 R-RNO-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-1296061 HCN channels 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-444411 Rhesus glycoproteins mediate ammonium transport. 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-1296067 Potassium transport channels 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-71737 Pyrophosphate hydrolysis 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-191647 c-src mediated regulation of Cx43 function and closure of gap junctions 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2395516 Electron transport from NADPH to Ferredoxin 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-428808 Na+-dependent glucose transporters 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-427589 Type II Na+/Pi cotransporters 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-977442 GABA A (rho) receptor activation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-156842 Eukaryotic Translation Elongation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-110331 Cleavage of the damaged purine 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2161517 Abacavir transmembrane transport 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-5660668 CLEC7A/inflammasome pathway 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-3000497 Scavenging by Class H Receptors 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-165181 Inhibition of TSC complex formation by PKB 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-379724 tRNA Aminoacylation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-77108 Utilization of Ketone Bodies 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-444209 Free fatty acid receptors 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-217271 FMO oxidises nucleophiles 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-8875791 MET activates STAT3 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-964975 Vitamins B6 activation to pyridoxal phosphate 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-111458 Formation of apoptosome 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-418890 Role of second messengers in netrin-1 signaling 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-8848584 Wax biosynthesis 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-156587 Amino Acid conjugation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2993913 Clearance of Nuclear Envelope Membranes from Chromatin 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-73927 Depurination 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-191650 Regulation of gap junction activity 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-159424 Conjugation of carboxylic acids 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-265473 Trafficking of dietary sterols 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-163282 Mitochondrial transcription initiation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2408557 Selenocysteine synthesis 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-173599 Formation of the active cofactor, UDP-glucuronate 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2465910 MASTL Facilitates Mitotic Progression 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-1299503 TWIK related potassium channel (TREK) 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-379401 Dopamine clearance from the synaptic cleft 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-1483248 Synthesis of PIPs at the ER membrane 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-418889 Ligand-independent caspase activation via DCC 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-3249367 STAT6-mediated induction of chemokines 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2142789 Ubiquinol biosynthesis 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-111464 SMAC-mediated dissociation of IAP:caspase complexes 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-139910 Activation of BMF and translocation to mitochondria 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2197563 NOTCH2 intracellular domain regulates transcription 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-111463 SMAC binds to IAPs 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-156582 Acetylation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-8849472 PTK6 Down-Regulation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-442745 Activation of CaMK IV 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-399710 Activation of AMPA receptors 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-162699 Synthesis of dolichyl-phosphate mannose 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-111469 SMAC-mediated apoptotic response 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-3065679 SUMO is proteolytically processed 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-177135 Conjugation of benzoate with glycine 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-5653890 Lactose synthesis 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-5627083 RHO GTPases regulate CFTR trafficking 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-426486 Small interfering RNA (siRNA) biogenesis 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-351200 Interconversion of polyamines 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-112313 Neurotransmitter uptake and Metabolism In Glial Cells 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-5624958 ARL13B-mediated ciliary trafficking of INPP5E 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-352238 Breakdown of the nuclear lamina 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-380615 Serotonin clearance from the synaptic cleft 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-113507 E2F-enabled inhibition of pre-replication complex formation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-2142850 Hyaluronan biosynthesis and export 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-173736 Alternative complement activation 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-381033 ATF6 (ATF6-alpha) activates chaperones 1.00000000001633 1.63331859320519e-11 3 0 0 115 7166 R-RNO-69275 G2/M Transition 1.00000000001681 1.68065176972418e-11 140 0 0 115 7166 R-RNO-73894 DNA Repair 1.00000000001709 1.70903974803763e-11 211 0 0 115 7166 R-RNO-15869 Metabolism of nucleotides 1.00000000001744 1.74361363910348e-11 90 0 0 115 7166 R-RNO-937061 TRIF-mediated TLR3/TLR4 signaling 1.00000000001758 1.75774707731906e-11 68 0 0 115 7166 R-RNO-195253 Degradation of beta-catenin by the destruction complex 1.00000000001758 1.75774707731906e-11 68 0 0 115 7166 R-RNO-168164 Toll Like Receptor 3 (TLR3) Cascade 1.00000000001758 1.75774707731906e-11 68 0 0 115 7166 R-RNO-69300 Removal of licensing factors from origins 1.00000000001758 1.75774707731906e-11 68 0 0 115 7166 R-RNO-166166 MyD88-independent TLR3/TLR4 cascade 1.00000000001758 1.75774707731906e-11 68 0 0 115 7166 R-RNO-674695 RNA Polymerase II Pre-transcription Events 1.00000000001758 1.75774707731906e-11 68 0 0 115 7166 R-RNO-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.00000000001758 1.75774707731906e-11 68 0 0 115 7166 R-RNO-69306 DNA Replication 1.00000000001798 1.79791397927829e-11 99 0 0 115 7166 R-RNO-453274 Mitotic G2-G2/M phases 1.00000000001808 1.80768039813128e-11 143 0 0 115 7166 R-RNO-453279 Mitotic G1-G1/S phases 1.00000000001812 1.81197400699347e-11 119 0 0 115 7166 R-RNO-983231 Factors involved in megakaryocyte development and platelet production 1.0000000000184 1.84024331640728e-11 78 0 0 115 7166 R-RNO-72613 Eukaryotic Translation Initiation 1.0000000000184 1.84024331640728e-11 78 0 0 115 7166 R-RNO-72737 Cap-dependent Translation Initiation 1.0000000000184 1.84024331640728e-11 78 0 0 115 7166 R-RNO-5389840 Mitochondrial translation elongation 1.0000000000184 1.84024331640728e-11 78 0 0 115 7166 R-RNO-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1.0000000000184 1.84024331640728e-11 78 0 0 115 7166 R-RNO-453276 Regulation of mitotic cell cycle 1.0000000000184 1.84024331640728e-11 78 0 0 115 7166 R-RNO-174143 APC/C-mediated degradation of cell cycle proteins 1.0000000000184 1.84024331640728e-11 78 0 0 115 7166 R-RNO-5617833 Cilium Assembly 1.0000000000185 1.84976074084503e-11 135 0 0 115 7166 R-RNO-3371556 Cellular response to heat stress 1.00000000001853 1.85333400670475e-11 63 0 0 115 7166 R-RNO-72689 Formation of a pool of free 40S subunits 1.00000000001853 1.85333400670475e-11 63 0 0 115 7166 R-RNO-68867 Assembly of the pre-replicative complex 1.00000000001853 1.85333400670475e-11 63 0 0 115 7166 R-RNO-114452 Activation of BH3-only proteins 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-182971 EGFR downregulation 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-1461973 Defensins 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-264876 Insulin processing 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-389357 CD28 dependent PI3K/Akt signaling 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-156584 Cytosolic sulfonation of small molecules 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-110320 Translesion Synthesis by POLH 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-909733 Interferon alpha/beta signaling 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-5654710 PI-3K cascade:FGFR3 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-77595 Processing of Intronless Pre-mRNAs 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-5654704 SHC-mediated cascade:FGFR3 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-176412 Phosphorylation of the APC/C 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-888590 GABA synthesis, release, reuptake and degradation 1.00000000001855 1.85540421014878e-11 17 0 0 115 7166 R-RNO-8868773 rRNA processing in the nucleus and cytosol 1.00000000001865 1.86479166951966e-11 124 0 0 115 7166 R-RNO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.00000000001865 1.86479166951966e-11 124 0 0 115 7166 R-RNO-72312 rRNA processing 1.00000000001865 1.86479166951966e-11 124 0 0 115 7166 R-RNO-5689880 Ub-specific processing proteases 1.00000000001909 1.90934415123484e-11 134 0 0 115 7166 R-RNO-69239 Synthesis of DNA 1.00000000002058 2.05820928412855e-11 92 0 0 115 7166 R-RNO-1852241 Organelle biogenesis and maintenance 1.00000000002098 2.09774894746731e-11 229 0 0 115 7166 R-RNO-8856688 Golgi-to-ER retrograde transport 1.00000000002122 2.12207684480846e-11 69 0 0 115 7166 R-RNO-5687128 MAPK6/MAPK4 signaling 1.00000000002122 2.12207684480846e-11 69 0 0 115 7166 R-RNO-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.00000000002122 2.12207684480846e-11 69 0 0 115 7166 R-RNO-69206 G1/S Transition 1.00000000002139 2.13854721103973e-11 105 0 0 115 7166 R-RNO-4839726 Chromatin organization 1.00000000002139 2.13854721103973e-11 105 0 0 115 7166 R-RNO-3247509 Chromatin modifying enzymes 1.00000000002139 2.13854721103973e-11 105 0 0 115 7166 R-RNO-156580 Phase II conjugation 1.00000000002143 2.14294875654034e-11 74 0 0 115 7166 R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1.00000000002143 2.14294875654034e-11 74 0 0 115 7166 R-RNO-2990846 SUMOylation 1.00000000002143 2.14294875654034e-11 74 0 0 115 7166 R-RNO-69620 Cell Cycle Checkpoints 1.00000000002229 2.2289862371932e-11 147 0 0 115 7166 R-RNO-381753 Olfactory Signaling Pathway 1.00000000004474 4.47393356744263e-11 558 0 0 115 7166