TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-RNO-500792 GPCR ligand binding 1.55382370239983e-05 -11.0722066670796 367 14 0.191780821917808 73 7166 60449,25083,58959,24806,29335,24925,366274,24316,24318,24808,64680,60590,25706,29237 Gnb3,Adra2a,Crhr1,Tac1,Oprk1,Adrb1,Ntsr1,Drd1,Drd2,Tacr3,Crhr2,Grm8,Cckbr,Penk R-RNO-375280 Amine ligand-binding receptors 0.000364811920957822 -7.91612862223381 34 4 0.0547945205479452 73 7166 24316,24318,24925,25083 Drd1,Drd2,Adrb1,Adra2a R-RNO-373076 Class A/1 (Rhodopsin-like receptors) 0.000455534392905117 -7.69403933828567 277 10 0.136986301369863 73 7166 25706,29237,24808,24316,24318,29335,24925,366274,25083,24806 Cckbr,Penk,Tacr3,Drd1,Drd2,Oprk1,Adrb1,Ntsr1,Adra2a,Tac1 R-RNO-209905 Catecholamine biosynthesis 0.000606118867810691 -7.40843443962736 4 2 0.0273972602739726 73 7166 25085,24311 Th,Ddc R-RNO-112316 Neuronal System 0.000618785460770766 -7.38775193538696 288 10 0.136986301369863 73 7166 60449,85426,24947,298908,24246,25101,298521,171146,29553,116745 Gnb3,Slc5a7,Gabra3,Kcnf1,Camk2d,Chrna3,Grik3,Kcnh5,Kcnk3,Kcnh6 R-RNO-390651 Dopamine receptors 0.00100353333835091 -6.90422816820607 5 2 0.0273972602739726 73 7166 24316,24318 Drd1,Drd2 R-RNO-380095 Tachykinin receptors bind tachykinins 0.00100353333835091 -6.90422816820607 5 2 0.0273972602739726 73 7166 24806,24808 Tac1,Tacr3 R-RNO-390696 Adrenoceptors 0.0020797346770363 -6.17551495252243 7 2 0.0273972602739726 73 7166 24925,25083 Adrb1,Adra2a R-RNO-1296071 Potassium Channels 0.00214420272245731 -6.14498748685853 90 5 0.0684931506849315 73 7166 298908,60449,171146,29553,116745 Kcnf1,Gnb3,Kcnh5,Kcnk3,Kcnh6 R-RNO-5576891 Cardiac conduction 0.00284486200241793 -5.86224071788152 96 5 0.0684931506849315 73 7166 25665,300992,24246,140448,29553 Scn5a,Cacna2d2,Camk2d,Slc8a3,Kcnk3 R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.00306460339112626 -5.78783711727305 29 3 0.0410958904109589 73 7166 25083,60449,300992 Adra2a,Gnb3,Cacna2d2 R-RNO-397014 Muscle contraction 0.00322885527313305 -5.7356276091665 143 6 0.0821917808219178 73 7166 300992,24246,25665,29553,140448,296369 Cacna2d2,Camk2d,Scn5a,Kcnk3,Slc8a3,Tnnc2 R-RNO-5576892 Phase 0 - rapid depolarisation 0.00407010368328061 -5.50408680484459 32 3 0.0410958904109589 73 7166 24246,300992,25665 Camk2d,Cacna2d2,Scn5a R-RNO-422356 Regulation of insulin secretion 0.00520213208810197 -5.25868672048605 69 4 0.0547945205479452 73 7166 300992,60449,24679,25083 Cacna2d2,Gnb3,Prkar2b,Adra2a R-RNO-425561 Sodium/Calcium exchangers 0.00530506165821038 -5.23909388432391 11 2 0.0273972602739726 73 7166 56814,140448 Slc24a1,Slc8a3 R-RNO-375276 Peptide ligand-binding receptors 0.00706906443720469 -4.95202713637233 168 6 0.0821917808219178 73 7166 24806,24808,29237,25706,366274,29335 Tac1,Tacr3,Penk,Cckbr,Ntsr1,Oprk1 R-RNO-1296072 Voltage gated Potassium channels 0.00712761440235193 -4.94377868646769 39 3 0.0410958904109589 73 7166 298908,171146,116745 Kcnf1,Kcnh5,Kcnh6 R-RNO-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 0.0078699103452452 -4.84470860858147 122 5 0.0684931506849315 73 7166 298521,24246,25101,24947,60449 Grik3,Camk2d,Chrna3,Gabra3,Gnb3 R-RNO-112315 Transmission across Chemical Synapses 0.00978048536626279 -4.62736616771463 180 6 0.0821917808219178 73 7166 298521,24246,24947,25101,60449,85426 Grik3,Camk2d,Gabra3,Chrna3,Gnb3,Slc5a7 R-RNO-209776 Amine-derived hormones 0.0112003328669598 -4.49181178085846 16 2 0.0273972602739726 73 7166 25085,24311 Th,Ddc R-RNO-373080 Class B/2 (Secretin family receptors) 0.0141169334547707 -4.26038024792764 50 3 0.0410958904109589 73 7166 64680,58959,60449 Crhr2,Crhr1,Gnb3 R-RNO-163685 Integration of energy metabolism 0.0151764045033354 -4.1880133925576 94 4 0.0547945205479452 73 7166 300992,25083,24679,60449 Cacna2d2,Adra2a,Prkar2b,Gnb3 R-RNO-446728 Cell junction organization 0.0156895506208348 -4.15476035376687 52 3 0.0410958904109589 73 7166 25409,29162,192362 Cdh6,Cdh7,Lamc2 R-RNO-392154 Nitric oxide stimulates guanylate cyclase 0.0172750617087112 -4.05849133719521 20 2 0.0273972602739726 73 7166 25523,497757 Prkg2,Gucy1a1 R-RNO-418346 Platelet homeostasis 0.0173571906317962 -4.05374841281147 54 3 0.0410958904109589 73 7166 140448,25523,497757 Slc8a3,Prkg2,Gucy1a1 R-RNO-201451 Signaling by BMP 0.0189690159669132 -3.96494836950069 21 2 0.0273972602739726 73 7166 289264,29373 Grem2,Bmp2 R-RNO-1299316 TWIK-releated acid-sensitive K+ channel (TASK) 0.0202716207160822 -3.89853336532176 2 1 0.0136986301369863 73 7166 29553 Kcnk3 R-RNO-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 0.0202716207160822 -3.89853336532176 2 1 0.0136986301369863 73 7166 25083 Adra2a R-RNO-5362798 Release of Hh-Np from the secreting cell 0.0202716207160822 -3.89853336532176 2 1 0.0136986301369863 73 7166 29499 Shh R-RNO-2022928 HS-GAG biosynthesis 0.0207299934404733 -3.87617366896126 22 2 0.0273972602739726 73 7166 294449,293451 Hs3st5,Hs3st2 R-RNO-382551 Transmembrane transport of small molecules 0.021676746900792 -3.8315151643709 547 11 0.150684931506849 73 7166 60449,56814,24679,85426,63882,171148,24947,140448,24246,24255,171144 Gnb3,Slc24a1,Prkar2b,Slc5a7,Asic4,Slc6a5,Gabra3,Slc8a3,Camk2d,Cftr,Slco4a1 R-RNO-418555 G alpha (s) signalling events 0.0247205705647446 -3.70011956556093 109 4 0.0547945205479452 73 7166 64680,58959,24925,24316 Crhr2,Crhr1,Adrb1,Drd1 R-RNO-418990 Adherens junctions interactions 0.0264001608238038 -3.63438517703767 25 2 0.0273972602739726 73 7166 29162,25409 Cdh7,Cdh6 R-RNO-5627083 RHO GTPases regulate CFTR trafficking 0.030254894263442 -3.49809731375971 3 1 0.0136986301369863 73 7166 24255 Cftr R-RNO-163359 Glucagon signaling in metabolic regulation 0.0304884595518892 -3.49040704231868 27 2 0.0273972602739726 73 7166 24679,60449 Prkar2b,Gnb3 R-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.0304884595518892 -3.49040704231868 27 2 0.0273972602739726 73 7166 29481,60449 Rgs9,Gnb3 R-RNO-391251 Protein folding 0.0326208286723746 -3.42280427829911 28 2 0.0273972602739726 73 7166 29481,60449 Rgs9,Gnb3 R-RNO-390466 Chaperonin-mediated protein folding 0.0326208286723746 -3.42280427829911 28 2 0.0273972602739726 73 7166 29481,60449 Rgs9,Gnb3 R-RNO-418594 G alpha (i) signalling events 0.0345617273909611 -3.36500835391801 178 5 0.0684931506849315 73 7166 29335,60590,24318,29237,25083 Oprk1,Grm8,Drd2,Penk,Adra2a R-RNO-162582 Signal Transduction 0.0359453800975869 -3.32575471218054 2192 30 0.410958904109589 73 7166 64680,25136,24808,24255,24318,24316,305156,366274,24806,58959,83620,24679,60449,192362,299802,29237,361714,25706,60590,29481,289264,24246,29499,140589,24925,29335,25756,25083,246217,29373 Crhr2,Gfra2,Tacr3,Cftr,Drd2,Drd1,Arhgap24,Ntsr1,Tac1,Crhr1,Cit,Prkar2b,Gnb3,Lamc2,Lgr5,Penk,Rasgrp2,Cckbr,Grm8,Rgs9,Grem2,Camk2d,Shh,Gli1,Adrb1,Oprk1,Cpt1b,Adra2a,Ngef,Bmp2 R-RNO-76009 Platelet Aggregation (Plug Formation) 0.0393544515798984 -3.23514618269258 31 2 0.0273972602739726 73 7166 25083,361714 Adra2a,Rasgrp2 R-RNO-5632681 Ligand-receptor interactions 0.0401378193945793 -3.21543626208762 4 1 0.0136986301369863 73 7166 29499 Shh R-RNO-421270 Cell-cell junction organization 0.0465651983725138 -3.06690183289703 34 2 0.0273972602739726 73 7166 25409,29162 Cdh6,Cdh7 R-RNO-2142712 Synthesis of 12-eicosatetraenoic acid derivatives 0.0499213909094939 -2.99730569253882 5 1 0.0136986301369863 73 7166 81639 Alox15 R-RNO-209931 Serotonin and melatonin biosynthesis 0.0499213909094939 -2.99730569253882 5 1 0.0136986301369863 73 7166 24311 Ddc R-RNO-500657 Presynaptic function of Kainate receptors 0.0499213909094939 -2.99730569253882 5 1 0.0136986301369863 73 7166 298521 Grik3 R-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.0516204849124181 -2.96383669084935 36 2 0.0273972602739726 73 7166 24679,60449 Prkar2b,Gnb3 R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.0516204849124181 -2.96383669084935 36 2 0.0273972602739726 73 7166 24679,60449 Prkar2b,Gnb3 R-RNO-1500931 Cell-Cell communication 0.0569654761435884 -2.86530987633827 86 3 0.0410958904109589 73 7166 25409,192362,29162 Cdh6,Lamc2,Cdh7 R-RNO-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 0.0595512577557891 -2.82091786239986 39 2 0.0273972602739726 73 7166 293451,294449 Hs3st2,Hs3st5 R-RNO-2142770 Synthesis of 15-eicosatetraenoic acid derivatives 0.059606593878023 -2.81998907549319 6 1 0.0136986301369863 73 7166 81639 Alox15 R-RNO-2214320 Anchoring fibril formation 0.059606593878023 -2.81998907549319 6 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-5625900 RHO GTPases activate CIT 0.059606593878023 -2.81998907549319 6 1 0.0136986301369863 73 7166 83620 Cit R-RNO-629587 Highly sodium permeable acetylcholine nicotinic receptors 0.059606593878023 -2.81998907549319 6 1 0.0136986301369863 73 7166 25101 Chrna3 R-RNO-445717 Aquaporin-mediated transport 0.0678714828325309 -2.69013932037591 42 2 0.0273972602739726 73 7166 24679,60449 Prkar2b,Gnb3 R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.069194403744364 -2.67083529037491 7 1 0.0136986301369863 73 7166 114491 Cited4 R-RNO-446107 Type I hemidesmosome assembly 0.069194403744364 -2.67083529037491 7 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-416476 G alpha (q) signalling events 0.0728436358886426 -2.61944010926961 155 4 0.0547945205479452 73 7166 24806,24808,25706,366274 Tac1,Tacr3,Cckbr,Ntsr1 R-RNO-1630316 Glycosaminoglycan metabolism 0.075921726869358 -2.57805237903085 97 3 0.0410958904109589 73 7166 25460,294449,293451 Hmmr,Hs3st5,Hs3st2 R-RNO-5576886 Phase 4 - resting membrane potential 0.0786857864142104 -2.54229274451766 8 1 0.0136986301369863 73 7166 29553 Kcnk3 R-RNO-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.0786857864142104 -2.54229274451766 8 1 0.0136986301369863 73 7166 29751 Sema3a R-RNO-70635 Urea cycle 0.0786857864142104 -2.54229274451766 8 1 0.0136986301369863 73 7166 25698 Ass1 R-RNO-5578775 Ion homeostasis 0.0795191093180637 -2.53175791742512 46 2 0.0273972602739726 73 7166 24246,140448 Camk2d,Slc8a3 R-RNO-372790 Signaling by GPCR 0.0847707954751667 -2.46780418848269 1272 18 0.246575342465753 73 7166 24246,60590,29237,25706,25083,246217,29335,24925,25136,24808,64680,24806,58959,24679,60449,366274,24318,24316 Camk2d,Grm8,Penk,Cckbr,Adra2a,Ngef,Oprk1,Adrb1,Gfra2,Tacr3,Crhr2,Tac1,Crhr1,Prkar2b,Gnb3,Ntsr1,Drd2,Drd1 R-RNO-8856828 Clathrin-mediated endocytosis 0.0853516314050969 -2.46097571562914 102 3 0.0410958904109589 73 7166 310839,24255,24805 Fnbp1l,Cftr,Syt2 R-RNO-977443 GABA receptor activation 0.0855613047457841 -2.45852214540099 48 2 0.0273972602739726 73 7166 24947,60449 Gabra3,Gnb3 R-RNO-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.0880816983442056 -2.42949050491657 9 1 0.0136986301369863 73 7166 25101 Chrna3 R-RNO-5358351 Signaling by Hedgehog 0.0892582227287711 -2.41622173115142 104 3 0.0410958904109589 73 7166 140589,29499,24679 Gli1,Shh,Prkar2b R-RNO-1296346 Tandem pore domain potassium channels 0.0973830866367608 -2.32910273190551 10 1 0.0136986301369863 73 7166 29553 Kcnk3 R-RNO-977441 GABA A receptor activation 0.0973830866367608 -2.32910273190551 10 1 0.0136986301369863 73 7166 24947 Gabra3 R-RNO-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 0.0973830866367608 -2.32910273190551 10 1 0.0136986301369863 73 7166 81639 Alox15 R-RNO-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.0973830866367608 -2.32910273190551 10 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.0973830866367608 -2.32910273190551 10 1 0.0136986301369863 73 7166 25523 Prkg2 R-RNO-8854518 AURKA Activation by TPX2 0.104465855213751 -2.25889500533586 54 2 0.0273972602739726 73 7166 25460,24679 Hmmr,Prkar2b R-RNO-2160916 Hyaluronan uptake and degradation 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 25460 Hmmr R-RNO-200425 Import of palmitoyl-CoA into the mitochondrial matrix 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 25756 Cpt1b R-RNO-400508 Incretin synthesis, secretion, and inactivation 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-622323 Presynaptic nicotinic acetylcholine receptors 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 25101 Chrna3 R-RNO-451308 Activation of Ca-permeable Kainate Receptor 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 298521 Grik3 R-RNO-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 25101 Chrna3 R-RNO-451306 Ionotropic activity of Kainate Receptors 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 298521 Grik3 R-RNO-1483213 Synthesis of PE 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 362261 Lpin3 R-RNO-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.106590889136166 -2.23875723866877 11 1 0.0136986301369863 73 7166 282636 Impa2 R-RNO-425407 SLC-mediated transmembrane transport 0.10777823151296 -2.22767957491573 248 5 0.0684931506849315 73 7166 171148,85426,56814,171144,140448 Slc6a5,Slc5a7,Slc24a1,Slco4a1,Slc8a3 R-RNO-418597 G alpha (z) signalling events 0.115706034501765 -2.15670248968829 12 1 0.0136986301369863 73 7166 25083 Adra2a R-RNO-4641263 Regulation of FZD by ubiquitination 0.115706034501765 -2.15670248968829 12 1 0.0136986301369863 73 7166 299802 Lgr5 R-RNO-392517 Rap1 signalling 0.115706034501765 -2.15670248968829 12 1 0.0136986301369863 73 7166 361714 Rasgrp2 R-RNO-8874081 MET activates PTK2 signaling 0.115706034501765 -2.15670248968829 12 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-418359 Reduction of cytosolic Ca++ levels 0.115706034501765 -2.15670248968829 12 1 0.0136986301369863 73 7166 140448 Slc8a3 R-RNO-181431 Acetylcholine Binding And Downstream Events 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 25101 Chrna3 R-RNO-5635838 Activation of SMO 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 29499 Shh R-RNO-418457 cGMP effects 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 25523 Prkg2 R-RNO-164378 PKA activation in glucagon signalling 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-3000157 Laminin interactions 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-163615 PKA activation 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-622327 Postsynaptic nicotinic acetylcholine receptors 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 25101 Chrna3 R-RNO-629602 Activation of Nicotinic Acetylcholine Receptors 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 25101 Chrna3 R-RNO-399954 Sema3A PAK dependent Axon repulsion 0.124729442312859 -2.08160834900933 13 1 0.0136986301369863 73 7166 29751 Sema3a R-RNO-2142845 Hyaluronan metabolism 0.133662023147738 -2.01244088049021 14 1 0.0136986301369863 73 7166 25460 Hmmr R-RNO-399956 CRMPs in Sema3A signaling 0.133662023147738 -2.01244088049021 14 1 0.0136986301369863 73 7166 29751 Sema3a R-RNO-111931 PKA-mediated phosphorylation of CREB 0.133662023147738 -2.01244088049021 14 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-442729 CREB phosphorylation through the activation of CaMKII 0.142504678673039 -1.94838044701916 15 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-438066 Unblocking of NMDA receptor, glutamate binding and activation 0.142504678673039 -1.94838044701916 15 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-451326 Activation of Kainate Receptors upon glutamate binding 0.142504678673039 -1.94838044701916 15 1 0.0136986301369863 73 7166 298521 Grik3 R-RNO-879518 Transport of organic anions 0.142504678673039 -1.94838044701916 15 1 0.0136986301369863 73 7166 171144 Slco4a1 R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle 0.142504678673039 -1.94838044701916 15 1 0.0136986301369863 73 7166 85426 Slc5a7 R-RNO-2682334 EPH-Ephrin signaling 0.145126000049399 -1.93015294803589 66 2 0.0273972602739726 73 7166 246217,306636 Ngef,Efnb2 R-RNO-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.150762338886852 -1.89205059672867 354 6 0.0821917808219178 73 7166 24806,25136,24808,24246,25706,366274 Tac1,Gfra2,Tacr3,Camk2d,Cckbr,Ntsr1 R-RNO-3928664 Ephrin signaling 0.15125830172624 -1.88876629613124 16 1 0.0136986301369863 73 7166 306636 Efnb2 R-RNO-442982 Ras activation uopn Ca2+ infux through NMDA receptor 0.15125830172624 -1.88876629613124 16 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-109582 Hemostasis 0.152952058693669 -1.87763074856297 435 7 0.0958904109589041 73 7166 25523,140448,50693,361714,497757,25083,24679 Prkg2,Slc8a3,Itih3,Rasgrp2,Gucy1a1,Adra2a,Prkar2b R-RNO-388396 GPCR downstream signaling 0.15536256786445 -1.86199374609702 1029 14 0.191780821917808 73 7166 60590,29237,25706,24808,64680,366274,29335,24925,24316,24318,24806,25083,58959,246217 Grm8,Penk,Cckbr,Tacr3,Crhr2,Ntsr1,Oprk1,Adrb1,Drd1,Drd2,Tac1,Adra2a,Crhr1,Ngef R-RNO-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.159923776410213 -1.83305797469779 17 1 0.0136986301369863 73 7166 114491 Cited4 R-RNO-5632684 Hedgehog 'on' state 0.162924757493218 -1.81446679522134 71 2 0.0273972602739726 73 7166 140589,29499 Gli1,Shh R-RNO-442660 Na+/Cl- dependent neurotransmitter transporters 0.168501978159857 -1.78080778943752 18 1 0.0136986301369863 73 7166 171148 Slc6a5 R-RNO-975298 Ligand-gated ion channel transport 0.168501978159857 -1.78080778943752 18 1 0.0136986301369863 73 7166 24947 Gabra3 R-RNO-877300 Interferon gamma signaling 0.168501978159857 -1.78080778943752 18 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-5683826 Surfactant metabolism 0.168501978159857 -1.78080778943752 18 1 0.0136986301369863 73 7166 25083 Adra2a R-RNO-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.173787845895886 -1.74992000015033 74 2 0.0273972602739726 73 7166 360838,54279 Lypd1,Cntn3 R-RNO-3371571 HSF1-dependent transactivation 0.17699377385106 -1.73164072300971 19 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis 0.181095510347228 -1.70873070541483 76 2 0.0273972602739726 73 7166 24255,24805 Cftr,Syt2 R-RNO-202131 Metabolism of nitric oxide 0.185400021855583 -1.68523950796698 20 1 0.0136986301369863 73 7166 25523 Prkg2 R-RNO-8875878 MET promotes cell motility 0.185400021855583 -1.68523950796698 20 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-203765 eNOS activation and regulation 0.185400021855583 -1.68523950796698 20 1 0.0136986301369863 73 7166 25523 Prkg2 R-RNO-5610787 Hedgehog 'off' state 0.192142966742417 -1.64951556559504 79 2 0.0273972602739726 73 7166 24679,140589 Prkar2b,Gli1 R-RNO-180024 DARPP-32 events 0.193721572150209 -1.64133334589978 21 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-3928663 EPHA-mediated growth cone collapse 0.201959266376697 -1.59968925351586 22 1 0.0136986301369863 73 7166 246217 Ngef R-RNO-983712 Ion channel transport 0.204152660868344 -1.58888722741296 153 3 0.0410958904109589 73 7166 24246,24947,63882 Camk2d,Gabra3,Asic4 R-RNO-2129379 Molecules associated with elastic fibres 0.210113937927188 -1.56010533383993 23 1 0.0136986301369863 73 7166 29373 Bmp2 R-RNO-5576893 Phase 2 - plateau phase 0.210113937927188 -1.56010533383993 23 1 0.0136986301369863 73 7166 300992 Cacna2d2 R-RNO-1296059 G protein gated Potassium channels 0.210113937927188 -1.56010533383993 23 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-1296041 Activation of G protein gated Potassium channels 0.210113937927188 -1.56010533383993 23 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-111997 CaM pathway 0.210113937927188 -1.56010533383993 23 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-111933 Calmodulin induced events 0.210113937927188 -1.56010533383993 23 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.210113937927188 -1.56010533383993 23 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-354192 Integrin alphaIIb beta3 signaling 0.218186412029815 -1.52240548052947 24 1 0.0136986301369863 73 7166 361714 Rasgrp2 R-RNO-418360 Platelet calcium homeostasis 0.218186412029815 -1.52240548052947 24 1 0.0136986301369863 73 7166 140448 Slc8a3 R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.218186412029815 -1.52240548052947 24 1 0.0136986301369863 73 7166 114113 Pafah1b3 R-RNO-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.221996674149612 -1.50509287853013 87 2 0.0273972602739726 73 7166 85426,171148 Slc5a7,Slc6a5 R-RNO-111996 Ca-dependent events 0.22617750583188 -1.48643516395903 25 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-5656169 Termination of translesion DNA synthesis 0.22617750583188 -1.48643516395903 25 1 0.0136986301369863 73 7166 100147704 Usp43 R-RNO-442742 CREB phosphorylation through the activation of Ras 0.22617750583188 -1.48643516395903 25 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.234088028458989 -1.45205804437047 26 1 0.0136986301369863 73 7166 29481 Rgs9 R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures 0.234088028458989 -1.45205804437047 26 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-390522 Striated Muscle Contraction 0.234088028458989 -1.45205804437047 26 1 0.0136986301369863 73 7166 296369 Tnnc2 R-RNO-2514856 The phototransduction cascade 0.241918781106913 -1.41915322441755 27 1 0.0136986301369863 73 7166 29481 Rgs9 R-RNO-399719 Trafficking of AMPA receptors 0.241918781106913 -1.41915322441755 27 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-420092 Glucagon-type ligand receptors 0.241918781106913 -1.41915322441755 27 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-1483191 Synthesis of PC 0.241918781106913 -1.41915322441755 27 1 0.0136986301369863 73 7166 362261 Lpin3 R-RNO-1489509 DAG and IP3 signaling 0.241918781106913 -1.41915322441755 27 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-399721 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 0.241918781106913 -1.41915322441755 27 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-4085001 Sialic acid metabolism 0.24967055712493 -1.38761300164457 28 1 0.0136986301369863 73 7166 29204 Neu2 R-RNO-194840 Rho GTPase cycle 0.255999426342459 -1.36258007535485 96 2 0.0273972602739726 73 7166 305156,246217 Arhgap24,Ngef R-RNO-1566948 Elastic fibre formation 0.257344142067424 -1.35734101565488 29 1 0.0136986301369863 73 7166 29373 Bmp2 R-RNO-1296065 Inwardly rectifying K+ channels 0.257344142067424 -1.35734101565488 29 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-212718 EGFR interacts with phospholipase C-gamma 0.257344142067424 -1.35734101565488 29 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 0.26358266200224 -1.33338825240833 98 2 0.0273972602739726 73 7166 140448,56814 Slc8a3,Slc24a1 R-RNO-111465 Apoptotic cleavage of cellular proteins 0.264940313797772 -1.32825070931602 30 1 0.0136986301369863 73 7166 298534 Clspn R-RNO-176187 Activation of ATR in response to replication stress 0.27245984253983 -1.30026404256471 31 1 0.0136986301369863 73 7166 298534 Clspn R-RNO-438064 Post NMDA receptor activation events 0.27245984253983 -1.30026404256471 31 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-3928665 EPH-ephrin mediated repulsion of cells 0.279903490963527 -1.27331041035727 32 1 0.0136986301369863 73 7166 306636 Efnb2 R-RNO-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 0.279903490963527 -1.27331041035727 32 1 0.0136986301369863 73 7166 100147704 Usp43 R-RNO-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events 0.294566160188758 -1.22225164852771 34 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-167021 PLC-gamma1 signalling 0.294566160188758 -1.22225164852771 34 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-977444 GABA B receptor activation 0.301786669204662 -1.19803490458266 35 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-991365 Activation of GABAB receptors 0.301786669204662 -1.19803490458266 35 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-194315 Signaling by Rho GTPases 0.302564898480106 -1.19545948409164 273 4 0.0547945205479452 73 7166 83620,246217,24255,305156 Cit,Ngef,Cftr,Arhgap24 R-RNO-3928662 EPHB-mediated forward signaling 0.30893427446933 -1.17462672869184 36 1 0.0136986301369863 73 7166 306636 Efnb2 R-RNO-1660662 Glycosphingolipid metabolism 0.316009701956423 -1.15198236347279 37 1 0.0136986301369863 73 7166 29204 Neu2 R-RNO-422475 Axon guidance 0.316504570560037 -1.15041759655419 366 5 0.0684931506849315 73 7166 24246,25136,306636,246217,29751 Camk2d,Gfra2,Efnb2,Ngef,Sema3a R-RNO-75153 Apoptotic execution phase 0.323013670502873 -1.13006063311679 38 1 0.0136986301369863 73 7166 298534 Clspn R-RNO-425397 Transport of vitamins, nucleosides, and related molecules 0.329946891887065 -1.10882357114838 39 1 0.0136986301369863 73 7166 171144 Slco4a1 R-RNO-112043 PLC beta mediated events 0.33681007091111 -1.08823609530594 40 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-193648 NRAGE signals death through JNK 0.33681007091111 -1.08823609530594 40 1 0.0136986301369863 73 7166 246217 Ngef R-RNO-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.33681007091111 -1.08823609530594 40 1 0.0136986301369863 73 7166 60590 Grm8 R-RNO-73893 DNA Damage Bypass 0.33681007091111 -1.08823609530594 40 1 0.0136986301369863 73 7166 100147704 Usp43 R-RNO-112040 G-protein mediated events 0.343603905433702 -1.06826572271515 41 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-936837 Ion transport by P-type ATPases 0.350329086473367 -1.0488823191873 42 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-1483249 Inositol phosphate metabolism 0.350329086473367 -1.0488823191873 42 1 0.0136986301369863 73 7166 282636 Impa2 R-RNO-5362517 Signaling by Retinoic Acid 0.350329086473367 -1.0488823191873 42 1 0.0136986301369863 73 7166 25756 Cpt1b R-RNO-112310 Neurotransmitter Release Cycle 0.356986298249027 -1.03005787819386 43 1 0.0136986301369863 73 7166 85426 Slc5a7 R-RNO-416482 G alpha (12/13) signalling events 0.37009951734473 -0.993983343712116 45 1 0.0136986301369863 73 7166 246217 Ngef R-RNO-1266738 Developmental Biology 0.376789359384452 -0.976068976104222 487 6 0.0821917808219178 73 7166 25136,24246,407758,306636,29751,246217 Gfra2,Camk2d,Krt26,Efnb2,Sema3a,Ngef R-RNO-373755 Semaphorin interactions 0.382948903174827 -0.959853710777842 47 1 0.0136986301369863 73 7166 29751 Sema3a R-RNO-6806834 Signaling by MET 0.389276298886562 -0.943465907579047 48 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-913531 Interferon Signaling 0.389276298886562 -0.943465907579047 48 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-71291 Metabolism of amino acids and derivatives 0.389578862443566 -0.942688963193887 220 3 0.0410958904109589 73 7166 24311,25698,25085 Ddc,Ass1,Th R-RNO-5689880 Ub-specific processing proteases 0.397866869933964 -0.921637827307875 134 2 0.0273972602739726 73 7166 298534,24255 Clspn,Cftr R-RNO-1474290 Collagen formation 0.401739720174093 -0.911950862310817 50 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-76002 Platelet activation, signaling and aggregation 0.406207192051225 -0.900891924302726 226 3 0.0410958904109589 73 7166 25083,361714,50693 Adra2a,Rasgrp2,Itih3 R-RNO-380259 Loss of Nlp from mitotic centrosomes 0.407877016472213 -0.896789580232358 51 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-5610780 Degradation of GLI1 by the proteasome 0.407877016472213 -0.896789580232358 51 1 0.0136986301369863 73 7166 140589 Gli1 R-RNO-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.407877016472213 -0.896789580232358 51 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-5358346 Hedgehog ligand biogenesis 0.413952206594521 -0.882004754829283 52 1 0.0136986301369863 73 7166 29499 Shh R-RNO-69275 G2/M Transition 0.419330090871913 -0.869096862839677 140 2 0.0273972602739726 73 7166 24679,25460 Prkar2b,Hmmr R-RNO-71387 Metabolism of carbohydrates 0.419970390796416 -0.867571068293603 231 3 0.0410958904109589 73 7166 293451,294449,25460 Hs3st2,Hs3st5,Hmmr R-RNO-204998 Cell death signalling via NRAGE, NRIF and NADE 0.425918741642943 -0.853506698224385 54 1 0.0136986301369863 73 7166 246217 Ngef R-RNO-2142753 Arachidonic acid metabolism 0.425918741642943 -0.853506698224385 54 1 0.0136986301369863 73 7166 81639 Alox15 R-RNO-453274 Mitotic G2-G2/M phases 0.429920864076757 -0.844154124262219 143 2 0.0273972602739726 73 7166 24679,25460 Prkar2b,Hmmr R-RNO-446219 Synthesis of substrates in N-glycan biosythesis 0.443418046980429 -0.813242281274056 57 1 0.0136986301369863 73 7166 29204 Neu2 R-RNO-380287 Centrosome maturation 0.449133405332788 -0.800435318816171 58 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-2980736 Peptide hormone metabolism 0.449133405332788 -0.800435318816171 58 1 0.0136986301369863 73 7166 60449 Gnb3 R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes 0.449133405332788 -0.800435318816171 58 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-111885 Opioid Signalling 0.460391020418459 -0.775679106194163 60 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-3371556 Cellular response to heat stress 0.47685327929275 -0.740546425990718 63 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition 0.492819983820426 -0.707611316001365 66 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-1474228 Degradation of the extracellular matrix 0.492819983820426 -0.707611316001365 66 1 0.0136986301369863 73 7166 192362 Lamc2 R-RNO-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 0.498034651594629 -0.697085622862846 67 1 0.0136986301369863 73 7166 29204 Neu2 R-RNO-8856688 Golgi-to-ER retrograde transport 0.508305850418383 -0.676671944821008 69 1 0.0136986301369863 73 7166 114113 Pafah1b3 R-RNO-5620912 Anchoring of the basal body to the plasma membrane 0.523325164375328 -0.647552278903617 72 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-351202 Metabolism of polyamines 0.52823033254786 -0.638222854512989 73 1 0.0136986301369863 73 7166 25698 Ass1 R-RNO-2672351 Stimuli-sensing channels 0.533085709085223 -0.629073062706096 74 1 0.0136986301369863 73 7166 63882 Asic4 R-RNO-193704 p75 NTR receptor-mediated signalling 0.533085709085223 -0.629073062706096 74 1 0.0136986301369863 73 7166 246217 Ngef R-RNO-428157 Sphingolipid metabolism 0.533085709085223 -0.629073062706096 74 1 0.0136986301369863 73 7166 29204 Neu2 R-RNO-2187338 Visual phototransduction 0.547358049051994 -0.602652122045964 77 1 0.0136986301369863 73 7166 29481 Rgs9 R-RNO-186763 Downstream signal transduction 0.55037009790968 -0.597164321764545 281 3 0.0410958904109589 73 7166 24679,24246,25136 Prkar2b,Camk2d,Gfra2 R-RNO-983231 Factors involved in megakaryocyte development and platelet production 0.552019194837205 -0.594172460053812 78 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-166520 Signalling by NGF 0.555036660325322 -0.588721112776995 384 4 0.0547945205479452 73 7166 24679,246217,24246,25136 Prkar2b,Ngef,Camk2d,Gfra2 R-RNO-6805567 Keratinization 0.55663299262723 -0.585849156355592 79 1 0.0136986301369863 73 7166 407758 Krt26 R-RNO-109581 Apoptosis 0.55663299262723 -0.585849156355592 79 1 0.0136986301369863 73 7166 298534 Clspn R-RNO-2424491 DAP12 signaling 0.5576665308367 -0.583994110231833 284 3 0.0410958904109589 73 7166 24679,25136,24246 Prkar2b,Gfra2,Camk2d R-RNO-177929 Signaling by EGFR 0.5576665308367 -0.583994110231833 284 3 0.0410958904109589 73 7166 24246,25136,24679 Camk2d,Gfra2,Prkar2b R-RNO-5688426 Deubiquitination 0.560486110501853 -0.578950817326737 183 2 0.0273972602739726 73 7166 298534,24255 Clspn,Cftr R-RNO-5357801 Programmed Cell Death 0.565720436973601 -0.569655250409855 81 1 0.0136986301369863 73 7166 298534 Clspn R-RNO-195258 RHO GTPase Effectors 0.569403364238635 -0.56316619576325 186 2 0.0273972602739726 73 7166 83620,24255 Cit,Cftr R-RNO-2172127 DAP12 interactions 0.57205207314689 -0.558525254775866 290 3 0.0410958904109589 73 7166 24679,25136,24246 Prkar2b,Gfra2,Camk2d R-RNO-186797 Signaling by PDGF 0.579139177219938 -0.546212455130653 293 3 0.0410958904109589 73 7166 24679,24246,25136 Prkar2b,Camk2d,Gfra2 R-RNO-199991 Membrane Trafficking 0.583922388843354 -0.537987200801516 398 4 0.0547945205479452 73 7166 24255,24805,310839,114113 Cftr,Syt2,Fnbp1l,Pafah1b3 R-RNO-382556 ABC-family proteins mediated transport 0.587643094249691 -0.531635497940559 86 1 0.0136986301369863 73 7166 24255 Cftr R-RNO-180336 SHC1 events in EGFR signaling 0.589710295265339 -0.528123887648614 193 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-179812 GRB2 events in EGFR signaling 0.589710295265339 -0.528123887648614 193 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-5673001 RAF/MAP kinase cascade 0.589710295265339 -0.528123887648614 193 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-112412 SOS-mediated signalling 0.589710295265339 -0.528123887648614 193 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-5684996 MAPK1/MAPK3 signaling 0.600998494723053 -0.509162849070611 197 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-2586552 Signaling by Leptin 0.603784582834556 -0.504537795598559 198 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-1474244 Extracellular matrix organization 0.603784582834556 -0.504537795598559 198 2 0.0273972602739726 73 7166 192362,29373 Lamc2,Bmp2 R-RNO-912526 Interleukin receptor SHC signaling 0.609313588403378 -0.495422220313183 200 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-375165 NCAM signaling for neurite out-growth 0.612056507150609 -0.490930668786703 201 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-187706 Signalling to p38 via RIT and RIN 0.614785039859594 -0.486482600958594 202 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-170984 ARMS-mediated activation 0.617499190770547 -0.482077520973905 203 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-1430728 Metabolism 0.618287500822734 -0.480801718014583 1635 16 0.219178082191781 73 7166 25460,29204,294449,81639,24679,60449,24311,282636,362261,300992,293451,25523,25083,25698,25756,25085 Hmmr,Neu2,Hs3st5,Alox15,Prkar2b,Gnb3,Ddc,Impa2,Lpin3,Cacna2d2,Hs3st2,Prkg2,Adra2a,Ass1,Cpt1b,Th R-RNO-170968 Frs2-mediated activation 0.620198965542557 -0.477714940258881 204 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-451927 Interleukin-2 signaling 0.622884371173582 -0.473394377462907 205 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-169893 Prolonged ERK activation events 0.622884371173582 -0.473394377462907 205 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-5218921 VEGFR2 mediated cell proliferation 0.622884371173582 -0.473394377462907 205 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-167044 Signalling to RAS 0.628212109657539 -0.464877415308308 207 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-187037 NGF signalling via TRKA from the plasma membrane 0.631039521449679 -0.46038678536001 316 3 0.0410958904109589 73 7166 24679,25136,24246 Prkar2b,Gfra2,Camk2d R-RNO-2871796 FCERI mediated MAPK activation 0.636096199228788 -0.452405470431111 210 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-5653656 Vesicle-mediated transport 0.6384387351486 -0.44872955932913 426 4 0.0547945205479452 73 7166 114113,310839,24255,24805 Pafah1b3,Fnbp1l,Cftr,Syt2 R-RNO-512988 Interleukin-3, 5 and GM-CSF signaling 0.638695609923681 -0.448327291894172 211 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-8853659 RET signaling 0.641280736363131 -0.444287951695555 212 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-187687 Signalling to ERKs 0.643851595489388 -0.440287021220236 213 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-1483206 Glycerophospholipid biosynthesis 0.657898632596317 -0.418704413329316 104 1 0.0136986301369863 73 7166 362261 Lpin3 R-RNO-5683057 MAPK family signaling cascades 0.663907238233501 -0.409612840720431 221 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-449147 Signaling by Interleukins 0.67452879646823 -0.393740911186746 337 3 0.0410958904109589 73 7166 24246,25136,362628 Camk2d,Gfra2,Ifnlr1 R-RNO-114608 Platelet degranulation 0.675223183722594 -0.392712000207818 109 1 0.0136986301369863 73 7166 50693 Itih3 R-RNO-76005 Response to elevated platelet cytosolic Ca2+ 0.691681807562647 -0.368629244773021 114 1 0.0136986301369863 73 7166 50693 Itih3 R-RNO-69481 G2/M Checkpoints 0.701159191762415 -0.355020325343363 117 1 0.0136986301369863 73 7166 298534 Clspn R-RNO-112399 IRS-mediated signalling 0.703556576889019 -0.351606983644286 238 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.704254010734122 -0.350616177198745 118 1 0.0136986301369863 73 7166 114113 Pafah1b3 R-RNO-392499 Metabolism of proteins 0.705867907128782 -0.348327159378516 894 8 0.10958904109589 73 7166 25083,60449,298534,29204,24255,360838,29481,54279 Adra2a,Gnb3,Clspn,Neu2,Cftr,Lypd1,Rgs9,Cntn3 R-RNO-2428928 IRS-related events triggered by IGF1R 0.710143511170479 -0.342288200962844 241 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-2428924 IGF1R signaling cascade 0.710143511170479 -0.342288200962844 241 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-74751 Insulin receptor signalling cascade 0.712312352797831 -0.339238766020123 242 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.712312352797831 -0.339238766020123 242 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-201681 TCF dependent signaling in response to WNT 0.719260194583117 -0.329532102743224 123 1 0.0136986301369863 73 7166 299802 Lgr5 R-RNO-535734 Fatty acid, triacylglycerol, and ketone body metabolism 0.719260194583117 -0.329532102743224 123 1 0.0136986301369863 73 7166 25756 Cpt1b R-RNO-5617833 Cilium Assembly 0.75227924231337 -0.284647691095758 135 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-74752 Signaling by Insulin receptor 0.756732616240508 -0.278745302945736 264 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-1433557 Signaling by SCF-KIT 0.758606291947606 -0.276272355604596 265 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-4420097 VEGFA-VEGFR2 Pathway 0.76231693591446 -0.271392883371969 267 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-194138 Signaling by VEGF 0.776677636227397 -0.252729897292306 275 2 0.0273972602739726 73 7166 25136,24246 Gfra2,Camk2d R-RNO-69620 Cell Cycle Checkpoints 0.781461730676426 -0.246589099383703 147 1 0.0136986301369863 73 7166 298534 Clspn R-RNO-1640170 Cell Cycle 0.804780239447476 -0.217186033308533 416 3 0.0410958904109589 73 7166 298534,24679,25460 Clspn,Prkar2b,Hmmr R-RNO-2454202 Fc epsilon receptor (FCERI) signaling 0.809354376354854 -0.211518415370411 295 2 0.0273972602739726 73 7166 24246,25136 Camk2d,Gfra2 R-RNO-1483257 Phospholipid metabolism 0.811243567800563 -0.209186939746503 161 1 0.0136986301369863 73 7166 362261 Lpin3 R-RNO-1280215 Cytokine Signaling in Immune system 0.817735839250895 -0.2012159294352 426 3 0.0410958904109589 73 7166 24246,25136,362628 Camk2d,Gfra2,Ifnlr1 R-RNO-597592 Post-translational protein modification 0.834213859957329 -0.181265482687776 679 5 0.0684931506849315 73 7166 360838,298534,29204,24255,54279 Lypd1,Clspn,Neu2,Cftr,Cntn3 R-RNO-195721 Signaling by Wnt 0.869299723115325 -0.140067307411692 196 1 0.0136986301369863 73 7166 299802 Lgr5 R-RNO-556833 Metabolism of lipids and lipoproteins 0.875283148935933 -0.133207846187393 605 4 0.0547945205479452 73 7166 81639,25756,362261,29204 Alox15,Cpt1b,Lpin3,Neu2 R-RNO-73894 DNA Repair 0.88841164333263 -0.118320081090262 211 1 0.0136986301369863 73 7166 100147704 Usp43 R-RNO-69278 Cell Cycle, Mitotic 0.890226152447879 -0.116279744660852 362 2 0.0273972602739726 73 7166 25460,24679 Hmmr,Prkar2b R-RNO-446203 Asparagine N-linked glycosylation 0.905763353528177 -0.098977206253882 227 1 0.0136986301369863 73 7166 29204 Neu2 R-RNO-1852241 Organelle biogenesis and maintenance 0.907735850978338 -0.0968018557236957 229 1 0.0136986301369863 73 7166 24679 Prkar2b R-RNO-2262752 Cellular responses to stress 0.956166639749353 -0.0448230717595997 299 1 0.0136986301369863 73 7166 24246 Camk2d R-RNO-212436 Generic Transcription Pathway 0.964990156199006 -0.0356373785252251 320 1 0.0136986301369863 73 7166 114491 Cited4 R-RNO-1280218 Adaptive Immune System 0.9944701554276 -0.00554519076374732 490 1 0.0136986301369863 73 7166 361714 Rasgrp2 R-RNO-168249 Innate Immune System 0.998339021706268 -0.00166235924754666 979 3 0.0410958904109589 73 7166 24679,24246,25136 Prkar2b,Camk2d,Gfra2 R-RNO-168256 Immune System 0.999169199935594 -0.000831145370046476 1364 5 0.0684931506849315 73 7166 362628,361714,24246,25136,24679 Ifnlr1,Rasgrp2,Camk2d,Gfra2,Prkar2b R-RNO-74160 Gene Expression 0.999940024045012 -5.99777536171348e-05 889 1 0.0136986301369863 73 7166 114491 Cited4 R-RNO-1538133 G0 and Early G1 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-1482788 Acyl chain remodelling of PC 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-425410 Metal ion SLC transporters 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-179409 APC-Cdc20 mediated degradation of Nek2A 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-3214842 HDMs demethylate histones 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-1236977 Endosomal/Vacuolar pathway 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-210500 Glutamate Neurotransmitter Release Cycle 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-499943 Synthesis and interconversion of nucleotide di- and triphosphates 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-196807 Nicotinate metabolism 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-191273 Cholesterol biosynthesis 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-6804758 Regulation of TP53 Activity through Acetylation 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-8948216 Collagen chain trimerization 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-5673000 RAF activation 0.99999999998818 -1.18198942932369e-11 21 0 0 73 7166 R-RNO-844456 The NLRP3 inflammasome 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-211935 Fatty acids 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-5686938 Regulation of TLR by endogenous ligand 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-198323 AKT phosphorylates targets in the cytosol 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-71182 Phenylalanine and tyrosine catabolism 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-418885 DCC mediated attractive signaling 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-199220 Vitamin B5 (pantothenate) metabolism 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-380320 Recruitment of NuMA to mitotic centrosomes 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-112308 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-391160 Signal regulatory protein (SIRP) family interactions 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-450341 Activation of the AP-1 family of transcription factors 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-73728 RNA Polymerase I Promoter Opening 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-2022923 Dermatan sulfate biosynthesis 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-190828 Gap junction trafficking 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-430116 GP1b-IX-V activation signalling 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-187015 Activation of TRKA receptors 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-936440 Negative regulators of RIG-I/MDA5 signaling 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-74749 Signal attenuation 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-432047 Passive transport by Aquaporins 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-174414 Processive synthesis on the C-strand of the telomere 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-71384 Ethanol oxidation 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-391908 Prostanoid ligand receptors 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-8851805 MET activates RAS signaling 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-1980148 Signaling by NOTCH3 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-1980150 Signaling by NOTCH4 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-193692 Regulated proteolysis of p75NTR 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-189451 Heme biosynthesis 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-419812 Calcitonin-like ligand receptors 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-549132 Organic cation/anion/zwitterion transport 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-73614 Pyrimidine salvage reactions 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-194002 Glucocorticoid biosynthesis 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-2022377 Metabolism of Angiotensinogen to Angiotensins 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-71240 Tryptophan catabolism 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-425381 Bicarbonate transporters 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-5250941 Negative epigenetic regulation of rRNA expression 0.999999999990699 -9.30125566982601e-12 10 0 0 73 7166 R-RNO-5368287 Mitochondrial translation 0.999999999991537 -8.46348754260076e-12 81 0 0 73 7166 R-RNO-2500257 Resolution of Sister Chromatid Cohesion 0.999999999991537 -8.46348754260076e-12 81 0 0 73 7166 R-RNO-8848021 Signaling by PTK6 0.999999999992068 -7.93195550090453e-12 52 0 0 73 7166 R-RNO-211000 Gene Silencing by RNA 0.999999999992068 -7.93195550090453e-12 52 0 0 73 7166 R-RNO-69473 G2/M DNA damage checkpoint 0.999999999992068 -7.93195550090453e-12 52 0 0 73 7166 R-RNO-73886 Chromosome Maintenance 0.999999999992068 -7.93195550090453e-12 52 0 0 73 7166 R-RNO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.999999999992068 -7.93195550090453e-12 52 0 0 73 7166 R-RNO-74259 Purine catabolism 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-5620922 BBSome-mediated cargo-targeting to cilium 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-381070 IRE1alpha activates chaperones 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-8875656 MET receptor recycling 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-418592 ADP signalling through P2Y purinoceptor 1 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-399997 Acetylcholine regulates insulin secretion 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-73929 Base-Excision Repair, AP Site Formation 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-5685939 HDR through MMEJ (alt-NHEJ) 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-8875555 MET activates RAP1 and RAC1 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-420029 Tight junction interactions 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-5218900 CASP8 activity is inhibited 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-1980143 Signaling by NOTCH1 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-428643 Organic anion transporters 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-4419969 Depolymerisation of the Nuclear Lamina 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-376172 DSCAM interactions 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-1660517 Synthesis of PIPs at the late endosome membrane 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-427359 SIRT1 negatively regulates rRNA Expression 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-69416 Dimerization of procaspase-8 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-977068 Termination of O-glycan biosynthesis 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-376176 Signaling by Robo receptor 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-3371378 Regulation by c-FLIP 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-389887 Beta-oxidation of pristanoyl-CoA 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-196780 Biotin transport and metabolism 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-1059683 Interleukin-6 signaling 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-2428933 SHC-related events triggered by IGF1R 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-390471 Association of TriC/CCT with target proteins during biosynthesis 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-975578 Reactions specific to the complex N-glycan synthesis pathway 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-140534 Ligand-dependent caspase activation 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-8876725 Protein methylation 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-6804759 Regulation of TP53 Activity through Association with Co-factors 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-174437 Removal of the Flap Intermediate from the C-strand 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-2022857 Keratan sulfate degradation 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-2468052 Establishment of Sister Chromatid Cohesion 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-209822 Glycoprotein hormones 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-419408 Lysosphingolipid and LPA receptors 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-1296052 Ca2+ activated K+ channels 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-1663150 The activation of arylsulfatases 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-3232118 SUMOylation of transcription factors 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-171306 Packaging Of Telomere Ends 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-74182 Ketone body metabolism 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-193993 Mineralocorticoid biosynthesis 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-937039 IRAK1 recruits IKK complex 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-3000480 Scavenging by Class A Receptors 0.999999999992096 -7.90442802768541e-12 9 0 0 73 7166 R-RNO-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 0.999999999992301 -7.6988721052758e-12 33 0 0 73 7166 R-RNO-157579 Telomere Maintenance 0.999999999992301 -7.6988721052758e-12 33 0 0 73 7166 R-RNO-6811440 Retrograde transport at the Trans-Golgi-Network 0.999999999992301 -7.6988721052758e-12 33 0 0 73 7166 R-RNO-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.999999999992301 -7.6988721052758e-12 33 0 0 73 7166 R-RNO-913709 O-linked glycosylation of mucins 0.999999999992301 -7.6988721052758e-12 33 0 0 73 7166 R-RNO-1442490 Collagen degradation 0.999999999992301 -7.6988721052758e-12 33 0 0 73 7166 R-RNO-109606 Intrinsic Pathway for Apoptosis 0.999999999992301 -7.6988721052758e-12 33 0 0 73 7166 R-RNO-113418 Formation of the Early Elongation Complex 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-982772 Growth hormone receptor signaling 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-5654696 Downstream signaling of activated FGFR2 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-5654687 Downstream signaling of activated FGFR1 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-73933 Resolution of Abasic Sites (AP sites) 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-5693579 Homologous DNA Pairing and Strand Exchange 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-1222556 ROS, RNS production in phagocytes 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-4086398 Ca2+ pathway 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-68962 Activation of the pre-replicative complex 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-6804757 Regulation of TP53 Degradation 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-6806003 Regulation of TP53 Expression and Degradation 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-5654727 Negative regulation of FGFR2 signaling 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-397795 G-protein beta:gamma signalling 0.999999999993651 -6.34913783272607e-12 29 0 0 73 7166 R-RNO-1483076 Synthesis of CL 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1483152 Hydrolysis of LPE 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1483148 Synthesis of PG 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-165160 PDE3B signalling 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1299361 TWIK-related alkaline pH activated K+ channel (TALK) 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-6814848 Glycerophospholipid catabolism 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1483196 PI and PC transport between ER and Golgi membranes 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-389542 NADPH regeneration 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-140180 COX reactions 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1299344 TWIK-related spinal cord K+ channel (TRESK) 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-211994 Sterols are 12-hydroxylated by CYP8B1 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-2029481 FCGR activation 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-177128 Conjugation of salicylate with glycine 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-5221030 TET1,2,3 and TDG demethylate DNA 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-2534343 Interaction With Cumulus Cells 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-211999 CYP2E1 reactions 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-975574 Reactions specific to the hybrid N-glycan synthesis pathway 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-5690714 CD22 mediated BCR regulation 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-181429 Serotonin Neurotransmitter Release Cycle 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-156902 Peptide chain elongation 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-6806664 Metabolism of vitamin K 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1855231 Synthesis of IPs in the ER lumen 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1369007 Mitochondrial ABC transporters 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1300645 Acrosome Reaction 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-351143 Agmatine biosynthesis 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1606341 IRF3 mediated activation of type 1 IFN 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-190827 Transport of connexins along the secretory pathway 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-6804754 Regulation of TP53 Expression 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-163316 Mitochondrial transcription termination 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-111448 Activation of NOXA and translocation to mitochondria 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-5263617 Metabolism of ingested MeSeO2H into MeSeH 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-350864 Regulation of thyroid hormone activity 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-447038 NrCAM interactions 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-379726 Mitochondrial tRNA aminoacylation 0.99999999999495 -5.04979565107977e-12 1 0 0 73 7166 R-RNO-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.99999999999534 -4.66044591536256e-12 60 0 0 73 7166 R-RNO-72202 Transport of Mature Transcript to Cytoplasm 0.99999999999534 -4.66044591536256e-12 60 0 0 73 7166 R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin 0.99999999999534 -4.66044591536256e-12 60 0 0 73 7166 R-RNO-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.99999999999534 -4.66044591536256e-12 60 0 0 73 7166 R-RNO-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.99999999999534 -4.66044591536256e-12 60 0 0 73 7166 R-RNO-927802 Nonsense-Mediated Decay (NMD) 0.999999999995875 -4.12526656103349e-12 72 0 0 73 7166 R-RNO-166054 Activated TLR4 signalling 0.999999999995875 -4.12526656103349e-12 72 0 0 73 7166 R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation 0.999999999995875 -4.12526656103349e-12 72 0 0 73 7166 R-RNO-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.999999999995875 -4.12526656103349e-12 72 0 0 73 7166 R-RNO-109704 PI3K Cascade 0.999999999995875 -4.12526656103349e-12 72 0 0 73 7166 R-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.999999999995875 -4.12526656103349e-12 72 0 0 73 7166 R-RNO-917937 Iron uptake and transport 0.999999999995969 -4.03064207296137e-12 40 0 0 73 7166 R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.999999999995969 -4.03064207296137e-12 40 0 0 73 7166 R-RNO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 0.999999999995969 -4.03064207296137e-12 40 0 0 73 7166 R-RNO-191859 snRNP Assembly 0.999999999996004 -3.99554469111459e-12 43 0 0 73 7166 R-RNO-194068 Bile acid and bile salt metabolism 0.999999999996004 -3.99554469111459e-12 43 0 0 73 7166 R-RNO-194441 Metabolism of non-coding RNA 0.999999999996004 -3.99554469111459e-12 43 0 0 73 7166 R-RNO-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.999999999996004 -3.99554469111459e-12 43 0 0 73 7166 R-RNO-1632852 Macroautophagy 0.999999999996205 -3.79481423152925e-12 53 0 0 73 7166 R-RNO-5676590 NIK-->noncanonical NF-kB signaling 0.999999999996205 -3.79481423152925e-12 53 0 0 73 7166 R-RNO-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.999999999996205 -3.79481423152925e-12 53 0 0 73 7166 R-RNO-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.999999999996205 -3.79481423152925e-12 53 0 0 73 7166 R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21 0.999999999996665 -3.33493510550477e-12 55 0 0 73 7166 R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs 0.999999999996665 -3.33493510550477e-12 55 0 0 73 7166 R-RNO-211897 Cytochrome P450 - arranged by substrate type 0.999999999996791 -3.20870870188882e-12 73 0 0 73 7166 R-RNO-4086400 PCP/CE pathway 0.999999999996791 -3.20870870188882e-12 73 0 0 73 7166 R-RNO-391903 Eicosanoid ligand-binding receptors 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-1480926 O2/CO2 exchange in erythrocytes 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-422085 Synthesis, secretion, and deacylation of Ghrelin 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-2299718 Condensation of Prophase Chromosomes 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-983189 Kinesins 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-3000171 Non-integrin membrane-ECM interactions 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5689901 Metalloprotease DUBs 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-6785807 Interleukin-4 and 13 signaling 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5656121 Translesion synthesis by POLI 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5099900 WNT5A-dependent internalization of FZD4 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-163210 Formation of ATP by chemiosmotic coupling 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-2559585 Oncogene Induced Senescence 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-112409 RAF-independent MAPK1/3 activation 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5655862 Translesion synthesis by POLK 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-1660514 Synthesis of PIPs at the Golgi membrane 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5205685 Pink/Parkin Mediated Mitophagy 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-5205647 Mitophagy 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-2453902 The canonical retinoid cycle in rods (twilight vision) 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-193639 p75NTR signals via NF-kB 0.999999999996873 -3.12667263353903e-12 15 0 0 73 7166 R-RNO-69052 Switching of origins to a post-replicative state 0.999999999996956 -3.04372853412721e-12 66 0 0 73 7166 R-RNO-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.999999999996956 -3.04372853412721e-12 66 0 0 73 7166 R-RNO-6807878 COPI-mediated anterograde transport 0.999999999996956 -3.04372853412721e-12 66 0 0 73 7166 R-RNO-68949 Orc1 removal from chromatin 0.999999999996956 -3.04372853412721e-12 66 0 0 73 7166 R-RNO-114508 Effects of PIP2 hydrolysis 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-5654689 PI-3K cascade:FGFR1 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-5654688 SHC-mediated cascade:FGFR1 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-5654712 FRS-mediated FGFR4 signaling 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-1482839 Acyl chain remodelling of PE 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-140875 Common Pathway of Fibrin Clot Formation 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-69273 Cyclin A/B1 associated events during G2/M transition 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-2029485 Role of phospholipids in phagocytosis 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-166208 mTORC1-mediated signalling 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-5621575 CD209 (DC-SIGN) signaling 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.999999999996966 -3.03431921901587e-12 20 0 0 73 7166 R-RNO-1638074 Keratan sulfate/keratin metabolism 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-5625740 RHO GTPases activate PKNs 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-1170546 Prolactin receptor signaling 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-390918 Peroxisomal lipid metabolism 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-8854214 TBC/RABGAPs 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-5693607 Processing of DNA double-strand break ends 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-211981 Xenobiotics 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-1592389 Activation of Matrix Metalloproteinases 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-445355 Smooth Muscle Contraction 0.999999999996997 -3.00295356872054e-12 28 0 0 73 7166 R-RNO-166058 MyD88:Mal cascade initiated on plasma membrane 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-168176 Toll Like Receptor 5 (TLR5) Cascade 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-181438 Toll Like Receptor 2 (TLR2) Cascade 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-975871 MyD88 cascade initiated on plasma membrane 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-3108232 SUMO E3 ligases SUMOylate target proteins 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-168142 Toll Like Receptor 10 (TLR10) Cascade 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.999999999997095 -2.90481239827388e-12 70 0 0 73 7166 R-RNO-210991 Basigin interactions 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-5357905 Regulation of TNFR1 signaling 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-5654733 Negative regulation of FGFR4 signaling 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-77387 Insulin receptor recycling 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-5218920 VEGFR2 mediated vascular permeability 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-389661 Glyoxylate metabolism and glycine degradation 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-2022854 Keratan sulfate biosynthesis 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-5654716 Downstream signaling of activated FGFR4 0.999999999997107 -2.8932898558484e-12 25 0 0 73 7166 R-RNO-5693538 Homology Directed Repair 0.999999999997454 -2.54607594634183e-12 58 0 0 73 7166 R-RNO-69580 p53-Dependent G1/S DNA damage checkpoint 0.999999999997454 -2.54607594634183e-12 58 0 0 73 7166 R-RNO-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.999999999997454 -2.54607594634183e-12 58 0 0 73 7166 R-RNO-1799339 SRP-dependent cotranslational protein targeting to membrane 0.999999999997454 -2.54607594634183e-12 58 0 0 73 7166 R-RNO-69563 p53-Dependent G1 DNA Damage Response 0.999999999997454 -2.54607594634183e-12 58 0 0 73 7166 R-RNO-1483255 PI Metabolism 0.999999999997454 -2.54607594634183e-12 58 0 0 73 7166 R-RNO-8855121 VLDL interactions 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-3000178 ECM proteoglycans 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-201722 Formation of the beta-catenin:TCF transactivating complex 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-75067 Processing of Capped Intronless Pre-mRNA 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-5689896 Ovarian tumor domain proteases 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-5693537 Resolution of D-Loop Structures 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-2426168 Activation of gene expression by SREBF (SREBP) 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-202433 Generation of second messenger molecules 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-5365859 RA biosynthesis pathway 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-70268 Pyruvate metabolism 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-3295583 TRP channels 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-1169408 ISG15 antiviral mechanism 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-1169410 Antiviral mechanism by IFN-stimulated genes 0.999999999997527 -2.47323675030827e-12 23 0 0 73 7166 R-RNO-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 0.999999999997551 -2.44929825613545e-12 44 0 0 73 7166 R-RNO-5578749 Transcriptional regulation by small RNAs 0.999999999997551 -2.44929825613545e-12 44 0 0 73 7166 R-RNO-5685942 HDR through Homologous Recombination (HRR) 0.999999999997551 -2.44929825613545e-12 44 0 0 73 7166 R-RNO-5628897 TP53 Regulates Metabolic Genes 0.999999999997551 -2.44929825613545e-12 44 0 0 73 7166 R-RNO-432722 Golgi Associated Vesicle Biogenesis 0.999999999997551 -2.44929825613545e-12 44 0 0 73 7166 R-RNO-5621481 C-type lectin receptors (CLRs) 0.999999999997739 -2.26056350832899e-12 104 0 0 73 7166 R-RNO-187042 TRKA activation by NGF 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-192456 Digestion of dietary lipid 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-111367 SLBP independent Processing of Histone Pre-mRNAs 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-1482883 Acyl chain remodeling of DAG and TAG 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-427601 Multifunctional anion exchangers 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-3215018 Processing and activation of SUMO 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-199920 CREB phosphorylation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-3371511 HSF1 activation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-428930 Thromboxane signalling through TP receptor 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-190873 Gap junction degradation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-71336 Pentose phosphate pathway (hexose monophosphate shunt) 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-112311 Neurotransmitter Clearance In The Synaptic Cleft 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-110329 Cleavage of the damaged pyrimidine 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-174430 Telomere C-strand synthesis initiation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-193634 Axonal growth inhibition (RHOA activation) 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-198693 AKT phosphorylates targets in the nucleus 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-388479 Vasopressin-like receptors 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-73928 Depyrimidination 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-937042 IRAK2 mediated activation of TAK1 complex 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-5173214 O-glycosylation of TSR domain-containing proteins 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-5357786 TNFR1-induced proapoptotic signaling 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-5652084 Fructose metabolism 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-111471 Apoptotic factor-mediated response 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-1834941 STING mediated induction of host immune responses 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-162791 Attachment of GPI anchor to uPAR 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-140342 Apoptosis induced DNA fragmentation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-196791 Vitamin D (calciferol) metabolism 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-416550 Sema4D mediated inhibition of cell attachment and migration 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-211227 Activation of DNA fragmentation factor 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-196836 Vitamin C (ascorbate) metabolism 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-112411 MAPK1 (ERK2) activation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-68952 DNA replication initiation 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-196025 Formation of annular gap junctions 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-429947 Deadenylation of mRNA 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-426117 Cation-coupled Chloride cotransporters 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-163767 PP2A-mediated dephosphorylation of key metabolic factors 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-2046105 Linoleic acid (LA) metabolism 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-2161522 Abacavir transport and metabolism 0.999999999997783 -2.21734474527553e-12 7 0 0 73 7166 R-RNO-6803529 FGFR2 alternative splicing 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-157118 Signaling by NOTCH 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-73848 Pyrimidine metabolism 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-5654700 FRS-mediated FGFR2 signaling 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-5654732 Negative regulation of FGFR3 signaling 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-2871809 FCERI mediated Ca+2 mobilization 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-174800 Chylomicron-mediated lipid transport 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-180786 Extension of Telomeres 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-5694530 Cargo concentration in the ER 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-6783589 Interleukin-6 family signaling 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-70614 Amino acid synthesis and interconversion (transamination) 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-5654708 Downstream signaling of activated FGFR3 0.999999999997799 -2.20062538541248e-12 24 0 0 73 7166 R-RNO-381119 Unfolded Protein Response (UPR) 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-196757 Metabolism of folate and pterines 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-156581 Methylation 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-2408522 Selenoamino acid metabolism 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-1810476 RIP-mediated NFkB activation via ZBP1 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-110312 Translesion synthesis by REV1 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-1963642 PI3K events in ERBB2 signaling 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-204174 Regulation of pyruvate dehydrogenase (PDH) complex 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-190242 FGFR1 ligand binding and activation 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-196299 Beta-catenin phosphorylation cascade 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-416993 Trafficking of GluR2-containing AMPA receptors 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-400685 Sema4D in semaphorin signaling 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-912694 Regulation of IFNA signaling 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-933542 TRAF6 mediated NF-kB activation 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-901032 ER Quality Control Compartment (ERQC) 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.999999999997982 -2.0184650047911e-12 14 0 0 73 7166 R-RNO-180292 GAB1 signalosome 0.999999999998109 -1.89118839453746e-12 109 0 0 73 7166 R-RNO-198203 PI3K/AKT activation 0.999999999998109 -1.89118839453746e-12 109 0 0 73 7166 R-RNO-5654743 Signaling by FGFR4 0.999999999998174 -1.82613195111893e-12 35 0 0 73 7166 R-RNO-166658 Complement cascade 0.999999999998174 -1.82613195111893e-12 35 0 0 73 7166 R-RNO-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.999999999998174 -1.82613195111893e-12 35 0 0 73 7166 R-RNO-5693571 Nonhomologous End-Joining (NHEJ) 0.999999999998174 -1.82613195111893e-12 35 0 0 73 7166 R-RNO-70153 Glucose transport 0.999999999998174 -1.82613195111893e-12 35 0 0 73 7166 R-RNO-5654741 Signaling by FGFR3 0.999999999998174 -1.82613195111893e-12 35 0 0 73 7166 R-RNO-165159 mTOR signalling 0.999999999998174 -1.82613195111893e-12 35 0 0 73 7166 R-RNO-187024 NGF-independant TRKA activation 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-205025 NADE modulates death signalling 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1912420 Pre-NOTCH Processing in Golgi 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-68616 Assembly of the ORC complex at the origin of replication 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-5626978 TNFR1-mediated ceramide production 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-196843 Vitamin B2 (riboflavin) metabolism 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-446199 Synthesis of Dolichyl-phosphate 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-71288 Creatine metabolism 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-211958 Miscellaneous substrates 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-8857538 PTK6 promotes HIF1A stabilization 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-5693548 Sensing of DNA Double Strand Breaks 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-444257 RSK activation 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-186712 Regulation of beta-cell development 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-68911 G2 Phase 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-110362 POLB-Dependent Long Patch Base Excision Repair 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-190370 FGFR1b ligand binding and activation 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-3270619 IRF3-mediated induction of type I IFN 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-5358493 Synthesis of diphthamide-EEF2 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-2142688 Synthesis of 5-eicosatetraenoic acids 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-420597 Nectin/Necl trans heterodimerization 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-879415 Advanced glycosylation endproduct receptor signaling 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-390247 Beta-oxidation of very long chain fatty acids 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-74713 IRS activation 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1362409 Mitochondrial iron-sulfur cluster biogenesis 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-392170 ADP signalling through P2Y purinoceptor 12 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-448706 Interleukin-1 processing 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-166665 Terminal pathway of complement 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-4641265 Repression of WNT target genes 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-190371 FGFR3b ligand binding and activation 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-72764 Eukaryotic Translation Termination 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-8851907 MET activates PI3K/AKT signaling 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1980145 Signaling by NOTCH2 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-6806942 MET Receptor Activation 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-6787639 GDP-fucose biosynthesis 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1461957 Beta defensins 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1253288 Downregulation of ERBB4 signaling 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-6783783 Interleukin-10 signaling 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-212676 Dopamine Neurotransmitter Release Cycle 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-6811555 PI5P Regulates TP53 Acetylation 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-444821 Relaxin receptors 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-549127 Organic cation transport 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-426496 Post-transcriptional silencing by small RNAs 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-176417 Phosphorylation of Emi1 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-804914 Transport of fatty acids 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-5576894 Phase 1 - inactivation of fast Na+ channels 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-500753 Pyrimidine biosynthesis 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-6798163 Choline catabolism 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-1912422 Pre-NOTCH Expression and Processing 0.99999999999819 -1.80980541670689e-12 6 0 0 73 7166 R-RNO-68884 Mitotic Telophase/Cytokinesis 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-202040 G-protein activation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1502540 Signaling by Activin 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5213460 RIPK1-mediated regulated necrosis 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-189483 Heme degradation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1475029 Reversible hydration of carbon dioxide 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-174411 Polymerase switching on the C-strand of the telomere 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-69109 Leading Strand Synthesis 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-2046106 alpha-linolenic acid (ALA) metabolism 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-997269 Inhibition of adenylate cyclase pathway 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1445148 Translocation of GLUT4 to the plasma membrane 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-69166 Removal of the Flap Intermediate 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-190322 FGFR4 ligand binding and activation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1295596 Spry regulation of FGF signaling 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5218859 Regulated Necrosis 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-430039 mRNA decay by 5' to 3' exoribonuclease 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1250347 SHC1 events in ERBB4 signaling 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1369062 ABC transporters in lipid homeostasis 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-157858 Gap junction trafficking and regulation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-139853 Elevation of cytosolic Ca2+ levels 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-190239 FGFR3 ligand binding and activation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-69091 Polymerase switching 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-8866427 VLDLR internalisation and degradation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-205043 NRIF signals cell death from the nucleus 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-2024096 HS-GAG degradation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5654227 Phospholipase C-mediated cascade; FGFR3 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-202670 ERKs are inactivated 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5682910 LGI-ADAM interactions 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5668599 RHO GTPases Activate NADPH Oxidases 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-209543 p75NTR recruits signalling complexes 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-2024101 CS/DS degradation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-170670 Adenylate cyclase inhibitory pathway 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5633008 TP53 Regulates Transcription of Cell Death Genes 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-389359 CD28 dependent Vav1 pathway 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-622312 Inflammasomes 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-190372 FGFR3c ligand binding and activation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-156588 Glucuronidation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-975577 N-Glycan antennae elongation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-877312 Regulation of IFNG signaling 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-190375 FGFR2c ligand binding and activation 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-111447 Activation of BAD and translocation to mitochondria 0.999999999998652 -1.3483785414822e-12 12 0 0 73 7166 R-RNO-1650814 Collagen biosynthesis and modifying enzymes 0.99999999999873 -1.2703331617511e-12 41 0 0 73 7166 R-RNO-5693606 DNA Double Strand Break Response 0.99999999999873 -1.2703331617511e-12 41 0 0 73 7166 R-RNO-1793185 Chondroitin sulfate/dermatan sulfate metabolism 0.99999999999873 -1.2703331617511e-12 41 0 0 73 7166 R-RNO-75105 Fatty Acyl-CoA Biosynthesis 0.99999999999873 -1.2703331617511e-12 41 0 0 73 7166 R-RNO-73884 Base Excision Repair 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-76046 RNA Polymerase III Transcription Initiation 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-1236974 ER-Phagosome pathway 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-5696395 Formation of Incision Complex in GG-NER 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-5675221 Negative regulation of MAPK pathway 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-6811438 Intra-Golgi traffic 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-69231 Cyclin D associated events in G1 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-5696400 Dual Incision in GG-NER 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-5696394 DNA Damage Recognition in GG-NER 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-74158 RNA Polymerase III Transcription 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-69236 G1 Phase 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-5620920 Cargo trafficking to the periciliary membrane 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-1483166 Synthesis of PA 0.999999999998839 -1.16130640354074e-12 30 0 0 73 7166 R-RNO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.999999999999561 -4.3896480922247e-13 46 0 0 73 7166 R-RNO-75815 Ubiquitin-dependent degradation of Cyclin D 0.999999999999561 -4.3896480922247e-13 46 0 0 73 7166 R-RNO-69610 p53-Independent DNA Damage Response 0.999999999999561 -4.3896480922247e-13 46 0 0 73 7166 R-RNO-69613 p53-Independent G1/S DNA damage checkpoint 0.999999999999561 -4.3896480922247e-13 46 0 0 73 7166 R-RNO-6799198 Complex I biogenesis 0.999999999999561 -4.3896480922247e-13 46 0 0 73 7166 R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6 0.999999999999561 -4.3896480922247e-13 46 0 0 73 7166 R-RNO-69229 Ubiquitin-dependent degradation of Cyclin D1 0.999999999999561 -4.3896480922247e-13 46 0 0 73 7166 R-RNO-72766 Translation 1.00000000000001 1.35274969471155e-14 93 0 0 73 7166 R-RNO-196849 Metabolism of water-soluble vitamins and cofactors 1.00000000000017 1.65822022486883e-13 95 0 0 73 7166 R-RNO-202403 TCR signaling 1.00000000000021 2.12732023779349e-13 97 0 0 73 7166 R-RNO-3858494 Beta-catenin independent WNT signaling 1.00000000000021 2.12732023779349e-13 97 0 0 73 7166 R-RNO-390650 Histamine receptors 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-937072 TRAF6 mediated induction of TAK1 complex 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1300642 Sperm Motility And Taxes 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-166187 Mitochondrial Uncoupling Proteins 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-8853383 Lysosomal oligosaccharide catabolism 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-8849470 PTK6 Regulates Cell Cycle 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-189085 Digestion of dietary carbohydrate 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-6799990 Metal sequestration by antimicrobial proteins 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-71262 Carnitine synthesis 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-75158 TRAIL signaling 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-111957 Cam-PDE 1 activation 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-75072 mRNA Editing 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1855191 Synthesis of IPs in the nucleus 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-176974 Unwinding of DNA 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-418217 G beta:gamma signalling through PLC beta 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1483115 Hydrolysis of LPC 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-204626 Hypusine synthesis from eIF5A-lysine 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-140179 Amine Oxidase reactions 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-163765 ChREBP activates metabolic gene expression 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-561048 Organic anion transport 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-75157 FasL/ CD95L signaling 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-447115 Interleukin-12 signaling 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-2161541 Abacavir metabolism 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-110381 Resolution of AP sites via the single-nucleotide replacement pathway 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1296025 ATP sensitive Potassium channels 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-6807062 Cholesterol biosynthesis via lathosterol 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-918233 TRAF3-dependent IRF activation pathway 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-5676934 Protein repair 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-8875513 MET interacts with TNS proteins 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-209563 Axonal growth stimulation 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-5662702 Melanin biosynthesis 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-167827 The proton buffering model 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-75944 Transcription from mitochondrial promoters 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-70688 Proline catabolism 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-165158 Activation of AKT2 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-447043 Neurofascin interactions 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-419771 Opsins 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1483226 Synthesis of PI 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-427975 Proton/oligopeptide cotransporters 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1306955 GRB7 events in ERBB2 signaling 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-888593 Reuptake of GABA 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-2243919 Crosslinking of collagen fibrils 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-8849474 PTK6 Activates STAT3 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1237112 Methionine salvage pathway 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-446205 Synthesis of GDP-mannose 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-6803544 Ion influx/efflux at host-pathogen interface 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-167060 NGF processing 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-2473224 Antagonism of Activin by Follistatin 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-167826 The fatty acid cycling model 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-6807047 Cholesterol biosynthesis via desmosterol 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-111932 CaMK IV-mediated phosphorylation of CREB 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-71032 Propionyl-CoA catabolism 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-1296053 Classical Kir channels 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-351906 Apoptotic cleavage of cell adhesion proteins 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-69478 G2/M DNA replication checkpoint 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-190861 Gap junction assembly 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-194306 Neurophilin interactions with VEGF and VEGFR 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-6783984 Glycine degradation 1.00000000000021 2.144207148017e-13 4 0 0 73 7166 R-RNO-435354 Zinc transporters 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-372708 p130Cas linkage to MAPK signaling for integrins 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-6807004 Negative regulation of MET activity 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-166663 Initial triggering of complement 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-69298 Association of licensing factors with the pre-replicative complex 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-5223345 Miscellaneous transport and binding events 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-6804760 Regulation of TP53 Activity through Methylation 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-6785631 ERBB2 Regulates Cell Motility 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-5358508 Mismatch Repair 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-69183 Processive synthesis on the lagging strand 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-1482922 Acyl chain remodelling of PI 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-202430 Translocation of ZAP-70 to Immunological synapse 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-2173788 Downregulation of TGF-beta receptor signaling 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-1660516 Synthesis of PIPs at the early endosome membrane 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-74217 Purine salvage 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-1592230 Mitochondrial biogenesis 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-162710 Synthesis of glycosylphosphatidylinositol (GPI) 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-429958 mRNA decay by 3' to 5' exoribonuclease 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-1250196 SHC1 events in ERBB2 signaling 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-5654228 Phospholipase C-mediated cascade; FGFR4 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-70221 Glycogen breakdown (glycogenolysis) 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-8873719 RAB geranylgeranylation 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-2151201 Transcriptional activation of mitochondrial biogenesis 1.00000000000023 2.33680412226052e-13 13 0 0 73 7166 R-RNO-2559583 Cellular Senescence 1.0000000000005 4.96123787314642e-13 102 0 0 73 7166 R-RNO-5357956 TNFR1-induced NFkappaB signaling pathway 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-373752 Netrin-1 signaling 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-69618 Mitotic Spindle Checkpoint 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-177504 Retrograde neurotrophin signalling 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-71403 Citric acid cycle (TCA cycle) 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-174048 APC/C:Cdc20 mediated degradation of Cyclin B 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-198753 ERK/MAPK targets 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-2022870 Chondroitin sulfate biosynthesis 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-5654706 FRS-mediated FGFR3 signaling 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-1679131 Trafficking and processing of endosomal TLR 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-5669034 TNFs bind their physiological receptors 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-437239 Recycling pathway of L1 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-901042 Calnexin/calreticulin cycle 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-389513 CTLA4 inhibitory signaling 1.0000000000006 6.04705388224669e-13 19 0 0 73 7166 R-RNO-72165 mRNA Splicing - Minor Pathway 1.00000000000076 7.57621329308779e-13 42 0 0 73 7166 R-RNO-1660499 Synthesis of PIPs at the plasma membrane 1.00000000000076 7.57621329308779e-13 42 0 0 73 7166 R-RNO-8852135 Protein ubiquitination 1.00000000000076 7.57621329308779e-13 42 0 0 73 7166 R-RNO-5654736 Signaling by FGFR1 1.00000000000076 7.57621329308779e-13 42 0 0 73 7166 R-RNO-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-2514853 Condensation of Prometaphase Chromosomes 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-8849468 PTK6 Regulates Proteins Involved in RNA Processing 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-2187335 The retinoid cycle in cones (daylight vision) 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-156711 Polo-like kinase mediated events 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-1566977 Fibronectin matrix formation 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-140834 Extrinsic Pathway of Fibrin Clot Formation 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-203641 NOSTRIN mediated eNOS trafficking 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-8935690 Miscellaneous digestion events 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-166786 Creation of C4 and C2 activators 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-433692 Proton-coupled monocarboxylate transport 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-390648 Muscarinic acetylcholine receptors 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-428890 Role of Abl in Robo-Slit signaling 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5627117 RHO GTPases Activate ROCKs 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-174577 Activation of C3 and C5 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-442720 CREB phosphorylation through the activation of Adenylate Cyclase 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-1169092 Activation of RAS in B cells 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-391906 Leukotriene receptors 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-427652 Sodium-coupled phosphate cotransporters 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-435368 Zinc efflux and compartmentalization by the SLC30 family 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-2142700 Synthesis of Lipoxins (LX) 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-1614517 Sulfide oxidation to sulfate 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5661270 Catabolism of glucuronate to xylulose-5-phosphate 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5674499 Negative feedback regulation of MAPK pathway 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-114516 Disinhibition of SNARE formation 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5625970 RHO GTPases activate KTN1 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-8865999 MET activates PTPN11 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5666185 RHO GTPases Activate Rhotekin and Rhophilins 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-211916 Vitamins 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-442717 CREB phosphorylation through the activation of CaMKK 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-111459 Activation of caspases through apoptosome-mediated cleavage 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-964739 N-glycan trimming and elongation in the cis-Golgi 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-389599 Alpha-oxidation of phytanate 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5689877 Josephin domain DUBs 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-75205 Dissolution of Fibrin Clot 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-196819 Vitamin B1 (thiamin) metabolism 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-111461 Cytochrome c-mediated apoptotic response 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-1482798 Acyl chain remodeling of CL 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-112307 Transmission across Electrical Synapses 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-70370 Galactose catabolism 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-977347 Serine biosynthesis 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5578768 Physiological factors 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-426048 Arachidonate production from DAG 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-70921 Histidine catabolism 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-3000471 Scavenging by Class B Receptors 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-8866423 VLDL biosynthesis 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-947581 Molybdenum cofactor biosynthesis 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5576890 Phase 3 - rapid repolarisation 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-173623 Classical antibody-mediated complement activation 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-2122947 NOTCH1 Intracellular Domain Regulates Transcription 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-417973 Adenosine P1 receptors 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-70350 Fructose catabolism 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-174362 Transport and synthesis of PAPS 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-193670 p75NTR negatively regulates cell cycle via SC1 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-1181150 Signaling by NODAL 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-211979 Eicosanoids 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-196783 Coenzyme A biosynthesis 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-112303 Electric Transmission Across Gap Junctions 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-8866376 Reelin signalling pathway 1.00000000000077 7.65872267514523e-13 5 0 0 73 7166 R-RNO-5668541 TNFR2 non-canonical NF-kB pathway 1.00000000000128 1.28432628137716e-12 85 0 0 73 7166 R-RNO-5663220 RHO GTPases Activate Formins 1.00000000000128 1.28432628137716e-12 85 0 0 73 7166 R-RNO-2132295 MHC class II antigen presentation 1.00000000000128 1.28432628137716e-12 85 0 0 73 7166 R-RNO-199418 Negative regulation of the PI3K/AKT network 1.0000000000013 1.30378801479275e-12 84 0 0 73 7166 R-RNO-5696398 Nucleotide Excision Repair 1.0000000000013 1.30378801479275e-12 84 0 0 73 7166 R-RNO-5685938 HDR through Single Strand Annealing (SSA) 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-392451 G beta:gamma signalling through PI3Kgamma 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-977606 Regulation of Complement cascade 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-380972 Energy dependent regulation of mTOR by LKB1-AMPK 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-156590 Glutathione conjugation 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-917977 Transferrin endocytosis and recycling 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-3301854 Nuclear Pore Complex (NPC) Disassembly 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-72086 mRNA Capping 1.0000000000014 1.40244059101199e-12 26 0 0 73 7166 R-RNO-156827 L13a-mediated translational silencing of Ceruloplasmin expression 1.00000000000143 1.43440741239721e-12 71 0 0 73 7166 R-RNO-69304 Regulation of DNA replication 1.00000000000143 1.43440741239721e-12 71 0 0 73 7166 R-RNO-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 1.00000000000143 1.43440741239721e-12 71 0 0 73 7166 R-RNO-166016 Toll Like Receptor 4 (TLR4) Cascade 1.00000000000148 1.47591738901454e-12 80 0 0 73 7166 R-RNO-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1.00000000000148 1.47591738901454e-12 80 0 0 73 7166 R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1.00000000000148 1.47591738901454e-12 80 0 0 73 7166 R-RNO-5419276 Mitochondrial translation termination 1.00000000000148 1.47591738901454e-12 80 0 0 73 7166 R-RNO-168138 Toll Like Receptor 9 (TLR9) Cascade 1.00000000000148 1.47591738901454e-12 80 0 0 73 7166 R-RNO-606279 Deposition of new CENPA-containing nucleosomes at the centromere 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-5627123 RHO GTPases activate PAKs 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-5654699 SHC-mediated cascade:FGFR2 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-168638 NOD1/2 Signaling Pathway 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-5654693 FRS-mediated FGFR1 signaling 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-110314 Recognition of DNA damage by PCNA-containing replication complex 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-189445 Metabolism of porphyrins 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-70895 Branched-chain amino acid catabolism 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-198725 Nuclear Events (kinase and transcription factor activation) 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-975576 N-glycan antennae elongation in the medial/trans-Golgi 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-3238698 WNT ligand biogenesis and trafficking 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-1614635 Sulfur amino acid metabolism 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-5654695 PI-3K cascade:FGFR2 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-69190 DNA strand elongation 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-174417 Telomere C-strand (Lagging Strand) Synthesis 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-774815 Nucleosome assembly 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-8863795 Downregulation of ERBB2 signaling 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-6783310 Fanconi Anemia Pathway 1.00000000000161 1.60769982952754e-12 22 0 0 73 7166 R-RNO-5607763 CLEC7A (Dectin-1) induces NFAT activation 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-416572 Sema4D induced cell migration and growth-cone collapse 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-3322077 Glycogen synthesis 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-73621 Pyrimidine catabolism 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-5675482 Regulation of necroptotic cell death 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-375281 Hormone ligand-binding receptors 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-417957 P2Y receptors 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-209952 Peptide hormone biosynthesis 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-1433559 Regulation of KIT signaling 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-3371568 Attenuation phase 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-73817 Purine ribonucleoside monophosphate biosynthesis 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-933541 TRAF6 mediated IRF7 activation 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-912631 Regulation of signaling by CBL 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-5626467 RHO GTPases activate IQGAPs 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-445095 Interaction between L1 and Ankyrins 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-1963640 GRB2 events in ERBB2 signaling 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-171007 p38MAPK events 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-446353 Cell-extracellular matrix interactions 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-197264 Nicotinamide salvaging 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-8847993 ERBB2 Activates PTK6 Signaling 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-3134975 Regulation of innate immune responses to cytosolic DNA 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-209560 NF-kB is activated and signals survival 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-428790 Facilitative Na+-independent glucose transporters 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-1462054 Alpha-defensins 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-416700 Other semaphorin interactions 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-5423646 Aflatoxin activation and detoxification 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-390666 Serotonin receptors 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-193048 Androgen biosynthesis 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-3000170 Syndecan interactions 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-1266695 Interleukin-7 signaling 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-203615 eNOS activation 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-190373 FGFR1c ligand binding and activation 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-68689 CDC6 association with the ORC:origin complex 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-71064 Lysine catabolism 1.00000000000184 1.83678398496253e-12 11 0 0 73 7166 R-RNO-2980766 Nuclear Envelope Breakdown 1.00000000000206 2.06115185660672e-12 36 0 0 73 7166 R-RNO-109703 PKB-mediated events 1.00000000000206 2.06115185660672e-12 36 0 0 73 7166 R-RNO-5633007 Regulation of TP53 Activity 1.00000000000215 2.15499919077886e-12 122 0 0 73 7166 R-RNO-73863 RNA Polymerase I Transcription Termination 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-432720 Lysosome Vesicle Biogenesis 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-73772 RNA Polymerase I Promoter Escape 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-6809371 Formation of the cornified envelope 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-70263 Gluconeogenesis 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-211976 Endogenous sterols 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-113510 E2F mediated regulation of DNA replication 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-4570464 SUMOylation of RNA binding proteins 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-5654726 Negative regulation of FGFR1 signaling 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-389356 CD28 co-stimulation 1.0000000000026 2.5971401488201e-12 27 0 0 73 7166 R-RNO-68827 CDT1 association with the CDC6:ORC:origin complex 1.00000000000294 2.93614793815574e-12 54 0 0 73 7166 R-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.00000000000294 2.93614793815574e-12 54 0 0 73 7166 R-RNO-204005 COPII (Coat Protein 2) Mediated Vesicle Transport 1.00000000000294 2.93614793815574e-12 54 0 0 73 7166 R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome 1.00000000000294 2.93614793815574e-12 54 0 0 73 7166 R-RNO-199992 trans-Golgi Network Vesicle Budding 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-73856 RNA Polymerase II Transcription Termination 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-6807505 RNA polymerase II transcribes snRNA genes 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-421837 Clathrin derived vesicle budding 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-388841 Costimulation by the CD28 family 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-3108214 SUMOylation of DNA damage response and repair proteins 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-450294 MAP kinase activation in TLR cascade 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-109688 Cleavage of Growing Transcript in the Termination Region 1.00000000000297 2.96516484828107e-12 56 0 0 73 7166 R-RNO-444411 Rhesus glycoproteins mediate ammonium transport. 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-1299503 TWIK related potassium channel (TREK) 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-111458 Formation of apoptosome 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2142850 Hyaluronan biosynthesis and export 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-156587 Amino Acid conjugation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-3000497 Scavenging by Class H Receptors 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-217271 FMO oxidises nucleophiles 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-8848584 Wax biosynthesis 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-77108 Utilization of Ketone Bodies 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-111464 SMAC-mediated dissociation of IAP:caspase complexes 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-159424 Conjugation of carboxylic acids 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-191647 c-src mediated regulation of Cx43 function and closure of gap junctions 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-964975 Vitamins B6 activation to pyridoxal phosphate 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-162699 Synthesis of dolichyl-phosphate mannose 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-193681 Ceramide signalling 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-111463 SMAC binds to IAPs 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-8875791 MET activates STAT3 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-379724 tRNA Aminoacylation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-379401 Dopamine clearance from the synaptic cleft 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-173599 Formation of the active cofactor, UDP-glucuronate 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-156842 Eukaryotic Translation Elongation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-113507 E2F-enabled inhibition of pre-replication complex formation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-265473 Trafficking of dietary sterols 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-111469 SMAC-mediated apoptotic response 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-71737 Pyrophosphate hydrolysis 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-1296061 HCN channels 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2465910 MASTL Facilitates Mitotic Progression 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2395516 Electron transport from NADPH to Ferredoxin 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2161517 Abacavir transmembrane transport 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-444209 Free fatty acid receptors 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-381033 ATF6 (ATF6-alpha) activates chaperones 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-139910 Activation of BMF and translocation to mitochondria 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-110331 Cleavage of the damaged purine 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-5660668 CLEC7A/inflammasome pathway 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-163282 Mitochondrial transcription initiation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-426486 Small interfering RNA (siRNA) biogenesis 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2408557 Selenocysteine synthesis 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-418890 Role of second messengers in netrin-1 signaling 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-380615 Serotonin clearance from the synaptic cleft 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2142789 Ubiquinol biosynthesis 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-399710 Activation of AMPA receptors 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-3065679 SUMO is proteolytically processed 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-3249367 STAT6-mediated induction of chemokines 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-427589 Type II Na+/Pi cotransporters 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-5653890 Lactose synthesis 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-977442 GABA A (rho) receptor activation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-165181 Inhibition of TSC complex formation by PKB 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-428808 Na+-dependent glucose transporters 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-173736 Alternative complement activation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-351200 Interconversion of polyamines 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-442745 Activation of CaMK IV 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-1296067 Potassium transport channels 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-1483248 Synthesis of PIPs at the ER membrane 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2197563 NOTCH2 intracellular domain regulates transcription 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-8849472 PTK6 Down-Regulation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-191650 Regulation of gap junction activity 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-177135 Conjugation of benzoate with glycine 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-2993913 Clearance of Nuclear Envelope Membranes from Chromatin 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-156582 Acetylation 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-112313 Neurotransmitter uptake and Metabolism In Glial Cells 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-73927 Depurination 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-418889 Ligand-independent caspase activation via DCC 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-5624958 ARL13B-mediated ciliary trafficking of INPP5E 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-352238 Breakdown of the nuclear lamina 1.00000000000328 3.28252710250906e-12 3 0 0 73 7166 R-RNO-70326 Glucose metabolism 1.00000000000334 3.33552807682994e-12 67 0 0 73 7166 R-RNO-5689603 UCH proteinases 1.00000000000334 3.33552807682994e-12 67 0 0 73 7166 R-RNO-3371453 Regulation of HSF1-mediated heat shock response 1.00000000000336 3.35761147519547e-12 47 0 0 73 7166 R-RNO-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.00000000000336 3.35761147519547e-12 47 0 0 73 7166 R-RNO-216083 Integrin cell surface interactions 1.00000000000356 3.55727913009132e-12 48 0 0 73 7166 R-RNO-114604 GPVI-mediated activation cascade 1.00000000000356 3.55727913009132e-12 48 0 0 73 7166 R-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation 1.00000000000356 3.55727913009132e-12 48 0 0 73 7166 R-RNO-350562 Regulation of ornithine decarboxylase (ODC) 1.00000000000356 3.55727913009132e-12 48 0 0 73 7166 R-RNO-4641257 Degradation of AXIN 1.00000000000356 3.55727913009132e-12 48 0 0 73 7166 R-RNO-73854 RNA Polymerase I Promoter Clearance 1.00000000000356 3.55727913009132e-12 48 0 0 73 7166 R-RNO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.00000000000356 3.55727913009132e-12 48 0 0 73 7166 R-RNO-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1.00000000000363 3.63412035674934e-12 39 0 0 73 7166 R-RNO-73762 RNA Polymerase I Transcription Initiation 1.00000000000363 3.63412035674934e-12 39 0 0 73 7166 R-RNO-446652 Interleukin-1 signaling 1.00000000000363 3.63412035674934e-12 39 0 0 73 7166 R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes 1.00000000000363 3.63412035674934e-12 39 0 0 73 7166 R-RNO-72702 Ribosomal scanning and start codon recognition 1.00000000000363 3.63412035674934e-12 39 0 0 73 7166 R-RNO-169911 Regulation of Apoptosis 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-5660526 Response to metal ions 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-190872 Transport of connexons to the plasma membrane 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-452723 Transcriptional regulation of pluripotent stem cells 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-480985 Synthesis of dolichyl-phosphate-glucose 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-381340 Transcriptional regulation of white adipocyte differentiation 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-163358 PKA-mediated phosphorylation of key metabolic factors 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-451307 Activation of Na-permeable Kainate Receptors 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-432030 Transport of glycerol from adipocytes to the liver by Aquaporins 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-3296197 Hydroxycarboxylic acid-binding receptors 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-177162 Conjugation of phenylacetate with glutamine 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-111457 Release of apoptotic factors from the mitochondria 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-1300652 Sperm:Oocyte Membrane Binding 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-171319 Telomere Extension By Telomerase 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-916853 Degradation of GABA 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-75064 mRNA Editing: A to I Conversion 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-379398 Enzymatic degradation of Dopamine by monoamine oxidase 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-5357572 Lysosomal glycogen catabolism 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-211163 AKT-mediated inactivation of FOXO1A 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-203754 NOSIP mediated eNOS trafficking 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-205017 NFG and proNGF binds to p75NTR 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-428776 Class II GLUTs 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-888568 GABA synthesis 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-379397 Enzymatic degradation of dopamine by COMT 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-1614603 Cysteine formation from homocysteine 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-166020 Transfer of LPS from LBP carrier to CD14 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-77042 Formation of editosomes by ADAR proteins 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-1483101 Synthesis of PS 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-69560 Transcriptional activation of p53 responsive genes 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-73943 Reversal of alkylation damage by DNA dioxygenases 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-379716 Cytosolic tRNA aminoacylation 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-69895 Transcriptional activation of cell cycle inhibitor p21 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-198765 Signalling to ERK5 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-75896 Plasmalogen biosynthesis 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-111446 Activation of BIM and translocation to mitochondria 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-392851 Prostacyclin signalling through prostacyclin receptor 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-1307965 betaKlotho-mediated ligand binding 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-75102 C6 deamination of adenosine 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-429593 Inositol transporters 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-111452 Activation and oligomerization of BAK protein 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-5661231 Metallothioneins bind metals 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-190374 FGFR1c and Klotho ligand binding and activation 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-381042 PERK regulates gene expression 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-73942 DNA Damage Reversal 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-72200 mRNA Editing: C to U Conversion 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-75094 Formation of the Editosome 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-114294 Activation, translocation and oligomerization of BAX 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-5652227 Fructose biosynthesis 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-8847453 Synthesis of PIPs in the nucleus 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-141334 PAOs oxidise polyamines to amines 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-844455 The NLRP1 inflammasome 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-210745 Regulation of gene expression in beta cells 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-68881 Mitotic Metaphase/Anaphase Transition 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-141424 Amplification of signal from the kinetochores 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-111995 phospho-PLA2 pathway 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-8854521 Interaction between PHLDA1 and AURKA 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-380612 Metabolism of serotonin 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-428559 Proton-coupled neutral amino acid transporters 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-190704 Oligomerization of connexins into connexons 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 1.00000000000406 4.05831225287583e-12 2 0 0 73 7166 R-RNO-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-1358803 Downregulation of ERBB2:ERBB3 signaling 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-194313 VEGF ligand-receptor interactions 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-75108 Activation, myristolyation of BID and translocation to mitochondria 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-203927 MicroRNA (miRNA) biogenesis 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-8850843 Phosphate bond hydrolysis by NTPDase proteins 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-5658623 FGFRL1 modulation of FGFR1 signaling 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-2470946 Cohesin Loading onto Chromatin 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-442380 Zinc influx into cells by the SLC39 gene family 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-190377 FGFR2b ligand binding and activation 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-1855167 Synthesis of pyrophosphates in the cytosol 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-193697 p75NTR regulates axonogenesis 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-1474165 Reproduction 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-432142 Platelet sensitization by LDL 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-8851680 Butyrophilin (BTN) family interactions 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-209968 Thyroxine biosynthesis 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-75892 Platelet Adhesion to exposed collagen 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-195399 VEGF binds to VEGFR leading to receptor dimerization 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-1250342 PI3K events in ERBB4 signaling 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-2179392 EGFR Transactivation by Gastrin 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-448424 Interleukin-17 signaling 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-446210 Synthesis of UDP-N-acetyl-glucosamine 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-427413 NoRC negatively regulates rRNA expression 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-381038 XBP1(S) activates chaperone genes 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-159740 Gamma-carboxylation of protein precursors 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-8937144 Aryl hydrocarbon receptor signalling 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-1187000 Fertilization 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-400451 Free fatty acids regulate insulin secretion 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-2393930 Phosphate bond hydrolysis by NUDT proteins 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-2485179 Activation of the phototransduction cascade 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-198745 Signalling to STAT3 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-727802 Transport of nucleotide sugars 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-72731 Recycling of eIF2:GDP 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-201688 WNT mediated activation of DVL 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-2995383 Initiation of Nuclear Envelope Reformation 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-77111 Synthesis of Ketone Bodies 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-196108 Pregnenolone biosynthesis 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-1614558 Degradation of cysteine and homocysteine 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-110357 Displacement of DNA glycosylase by APEX1 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-8854691 Interleukin-19, 20, 22, 24 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-110056 MAPK3 (ERK1) activation 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-425986 Sodium/Proton exchangers 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-419037 NCAM1 interactions 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-350054 Notch-HLH transcription pathway 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-2995410 Nuclear Envelope Reassembly 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-163680 AMPK inhibits chREBP transcriptional activation activity 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-193144 Estrogen biosynthesis 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-174403 Glutathione synthesis and recycling 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-170660 Adenylate cyclase activating pathway 1.00000000000413 4.13291039259565e-12 8 0 0 73 7166 R-RNO-69202 Cyclin E associated events during G1/S transition 1.00000000000421 4.20531989244906e-12 61 0 0 73 7166 R-RNO-611105 Respiratory electron transport 1.00000000000421 4.20531989244906e-12 61 0 0 73 7166 R-RNO-69656 Cyclin A:Cdk2-associated events at S phase entry 1.00000000000421 4.20531989244906e-12 61 0 0 73 7166 R-RNO-75109 Triglyceride Biosynthesis 1.00000000000421 4.20531989244906e-12 61 0 0 73 7166 R-RNO-5658442 Regulation of RAS by GAPs 1.00000000000421 4.20531989244906e-12 61 0 0 73 7166 R-RNO-72163 mRNA Splicing - Major Pathway 1.00000000000434 4.34035703200041e-12 151 0 0 73 7166 R-RNO-211945 Phase 1 - Functionalization of compounds 1.00000000000442 4.42048776996898e-12 123 0 0 73 7166 R-RNO-5693532 DNA Double-Strand Break Repair 1.00000000000444 4.43867414102843e-12 100 0 0 73 7166 R-RNO-174824 Lipoprotein metabolism 1.00000000000491 4.91369384785951e-12 65 0 0 73 7166 R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 1.00000000000491 4.91369384785951e-12 65 0 0 73 7166 R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.00000000000491 4.91369384785951e-12 65 0 0 73 7166 R-RNO-168898 Toll-Like Receptors Cascades 1.00000000000493 4.92835720797222e-12 112 0 0 73 7166 R-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1.00000000000513 5.12652155899955e-12 83 0 0 73 7166 R-RNO-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-6788467 IL-6-type cytokine receptor ligand interactions 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-194223 HDL-mediated lipid transport 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-525793 Myogenesis 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-212300 PRC2 methylates histones and DNA 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-2173789 TGF-beta receptor signaling activates SMADs 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-5654719 SHC-mediated cascade:FGFR4 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-171052 LDL-mediated lipid transport 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-375170 CDO in myogenesis 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-159418 Recycling of bile acids and salts 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-450302 activated TAK1 mediates p38 MAPK activation 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-69186 Lagging Strand Synthesis 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-210993 Tie2 Signaling 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-445144 Signal transduction by L1 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-75876 Synthesis of very long-chain fatty acyl-CoAs 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-5654720 PI-3K cascade:FGFR4 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-389948 PD-1 signaling 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-5620916 VxPx cargo-targeting to cilium 1.00000000000523 5.23323910302574e-12 18 0 0 73 7166 R-RNO-192105 Synthesis of bile acids and bile salts 1.00000000000539 5.38975107562162e-12 32 0 0 73 7166 R-RNO-429914 Deadenylation-dependent mRNA decay 1.00000000000539 5.38975107562162e-12 32 0 0 73 7166 R-RNO-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 1.00000000000539 5.38975107562162e-12 32 0 0 73 7166 R-RNO-73847 Purine metabolism 1.00000000000539 5.38975107562162e-12 32 0 0 73 7166 R-RNO-196071 Metabolism of steroid hormones 1.00000000000539 5.38975107562162e-12 32 0 0 73 7166 R-RNO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-1236394 Signaling by ERBB4 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-72649 Translation initiation complex formation 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-73776 RNA Polymerase II Promoter Escape 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-975634 Retinoid metabolism and transport 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-380108 Chemokine receptors bind chemokines 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-75953 RNA Polymerase II Transcription Initiation 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-1227986 Signaling by ERBB2 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-73887 Death Receptor Signalling 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-140877 Formation of Fibrin Clot (Clotting Cascade) 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-189200 Hexose transport 1.00000000000549 5.48542431736963e-12 38 0 0 73 7166 R-RNO-3700989 Transcriptional Regulation by TP53 1.00000000000564 5.63877448787046e-12 226 0 0 73 7166 R-RNO-73923 Lipid digestion, mobilization, and transport 1.00000000000571 5.70552167771116e-12 94 0 0 73 7166 R-RNO-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 1.00000000000586 5.85828261078115e-12 110 0 0 73 7166 R-RNO-5607764 CLEC7A (Dectin-1) signaling 1.00000000000589 5.889763636048e-12 86 0 0 73 7166 R-RNO-68877 Mitotic Prometaphase 1.00000000000589 5.889763636048e-12 86 0 0 73 7166 R-RNO-68875 Mitotic Prophase 1.0000000000059 5.901533485708e-12 59 0 0 73 7166 R-RNO-69615 G1/S DNA Damage Checkpoints 1.0000000000059 5.901533485708e-12 59 0 0 73 7166 R-RNO-72203 Processing of Capped Intron-Containing Pre-mRNA 1.0000000000061 6.10138663443743e-12 198 0 0 73 7166 R-RNO-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.00000000000649 6.48908448495791e-12 57 0 0 73 7166 R-RNO-1169091 Activation of NF-kappaB in B cells 1.00000000000649 6.48908448495791e-12 57 0 0 73 7166 R-RNO-5654221 Phospholipase C-mediated cascade; FGFR2 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-77595 Processing of Intronless Pre-mRNAs 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-5674135 MAP2K and MAPK activation 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-176412 Phosphorylation of the APC/C 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-156584 Cytosolic sulfonation of small molecules 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-264876 Insulin processing 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-389357 CD28 dependent PI3K/Akt signaling 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-909733 Interferon alpha/beta signaling 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-110320 Translesion Synthesis by POLH 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-114452 Activation of BH3-only proteins 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-182971 EGFR downregulation 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-5654704 SHC-mediated cascade:FGFR3 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-190241 FGFR2 ligand binding and activation 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-2028269 Signaling by Hippo 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-888590 GABA synthesis, release, reuptake and degradation 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-5654710 PI-3K cascade:FGFR3 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-1461973 Defensins 1.00000000000665 6.65153408756915e-12 17 0 0 73 7166 R-RNO-5654738 Signaling by FGFR2 1.00000000000711 7.11207550220922e-12 64 0 0 73 7166 R-RNO-2871837 FCERI mediated NF-kB activation 1.00000000000711 7.11207550220922e-12 64 0 0 73 7166 R-RNO-15869 Metabolism of nucleotides 1.00000000000726 7.26249219181626e-12 90 0 0 73 7166 R-RNO-202733 Cell surface interactions at the vascular wall 1.00000000000726 7.26249219181626e-12 90 0 0 73 7166 R-RNO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 1.00000000000737 7.36807886265867e-12 49 0 0 73 7166 R-RNO-373760 L1CAM interactions 1.00000000000737 7.36807886265867e-12 49 0 0 73 7166 R-RNO-212165 Epigenetic regulation of gene expression 1.00000000000737 7.36807886265867e-12 49 0 0 73 7166 R-RNO-202424 Downstream TCR signaling 1.00000000000765 7.65114428362116e-12 82 0 0 73 7166 R-RNO-4839726 Chromatin organization 1.00000000000786 7.85611810761261e-12 105 0 0 73 7166 R-RNO-69206 G1/S Transition 1.00000000000786 7.85611810761261e-12 105 0 0 73 7166 R-RNO-3247509 Chromatin modifying enzymes 1.00000000000786 7.85611810761261e-12 105 0 0 73 7166 R-RNO-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 1.00000000000796 7.96314935311923e-12 76 0 0 73 7166 R-RNO-975155 MyD88 dependent cascade initiated on endosome 1.00000000000796 7.96314935311923e-12 76 0 0 73 7166 R-RNO-3214847 HATs acetylate histones 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-5620924 Intraflagellar transport 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-3769402 Deactivation of the beta-catenin transactivating complex 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-75893 TNF signaling 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-5250913 Positive epigenetic regulation of rRNA expression 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-5250924 B-WICH complex positively regulates rRNA expression 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-73777 RNA Polymerase I Chain Elongation 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-4615885 SUMOylation of DNA replication proteins 1.00000000000808 8.08100357329245e-12 34 0 0 73 7166 R-RNO-69002 DNA Replication Pre-Initiation 1.00000000000812 8.12365418308343e-12 77 0 0 73 7166 R-RNO-68874 M/G1 Transition 1.00000000000812 8.12365418308343e-12 77 0 0 73 7166 R-RNO-112382 Formation of RNA Pol II elongation complex 1.00000000000844 8.44313982439594e-12 51 0 0 73 7166 R-RNO-4641258 Degradation of DVL 1.00000000000844 8.44313982439594e-12 51 0 0 73 7166 R-RNO-6782135 Dual incision in TC-NER 1.00000000000844 8.44313982439594e-12 51 0 0 73 7166 R-RNO-75955 RNA Polymerase II Transcription Elongation 1.00000000000844 8.44313982439594e-12 51 0 0 73 7166 R-RNO-6803157 Antimicrobial peptides 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-2559580 Oxidative Stress Induced Senescence 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-170834 Signaling by TGF-beta Receptor Complex 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-69541 Stabilization of p53 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-174113 SCF-beta-TrCP mediated degradation of Emi1 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-6794362 Protein-protein interactions at synapses 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-4608870 Asymmetric localization of PCP proteins 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-72187 mRNA 3'-end processing 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-5173105 O-linked glycosylation 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-73864 RNA Polymerase I Transcription 1.00000000000873 8.73180007191101e-12 50 0 0 73 7166 R-RNO-6794361 Interactions of neurexins and neuroligins at synapses 1.000000000009 9.00251997258415e-12 37 0 0 73 7166 R-RNO-3214841 PKMTs methylate histone lysines 1.000000000009 9.00251997258415e-12 37 0 0 73 7166 R-RNO-1660661 Sphingolipid de novo biosynthesis 1.000000000009 9.00251997258415e-12 37 0 0 73 7166 R-RNO-5687128 MAPK6/MAPK4 signaling 1.00000000000937 9.37043668336447e-12 69 0 0 73 7166 R-RNO-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.00000000000937 9.37043668336447e-12 69 0 0 73 7166 R-RNO-383280 Nuclear Receptor transcription pathway 1.00000000000944 9.43958991393329e-12 45 0 0 73 7166 R-RNO-6781823 Formation of TC-NER Pre-Incision Complex 1.00000000000944 9.43958991393329e-12 45 0 0 73 7166 R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.00000000000944 9.43958991393329e-12 45 0 0 73 7166 R-RNO-6806667 Metabolism of fat-soluble vitamins 1.00000000000944 9.43958991393329e-12 45 0 0 73 7166 R-RNO-1834949 Cytosolic sensors of pathogen-associated DNA 1.00000000000944 9.43958991393329e-12 45 0 0 73 7166 R-RNO-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.00000000000962 9.61731178596201e-12 68 0 0 73 7166 R-RNO-937061 TRIF-mediated TLR3/TLR4 signaling 1.00000000000962 9.61731178596201e-12 68 0 0 73 7166 R-RNO-195253 Degradation of beta-catenin by the destruction complex 1.00000000000962 9.61731178596201e-12 68 0 0 73 7166 R-RNO-166166 MyD88-independent TLR3/TLR4 cascade 1.00000000000962 9.61731178596201e-12 68 0 0 73 7166 R-RNO-69300 Removal of licensing factors from origins 1.00000000000962 9.61731178596201e-12 68 0 0 73 7166 R-RNO-674695 RNA Polymerase II Pre-transcription Events 1.00000000000962 9.61731178596201e-12 68 0 0 73 7166 R-RNO-168164 Toll Like Receptor 3 (TLR3) Cascade 1.00000000000962 9.61731178596201e-12 68 0 0 73 7166 R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs 1.00000000000976 9.76191939005349e-12 31 0 0 73 7166 R-RNO-3299685 Detoxification of Reactive Oxygen Species 1.00000000000976 9.76191939005349e-12 31 0 0 73 7166 R-RNO-3214858 RMTs methylate histone arginines 1.00000000000976 9.76191939005349e-12 31 0 0 73 7166 R-RNO-70171 Glycolysis 1.00000000000976 9.76191939005349e-12 31 0 0 73 7166 R-RNO-352230 Amino acid transport across the plasma membrane 1.00000000000976 9.76191939005349e-12 31 0 0 73 7166 R-RNO-69239 Synthesis of DNA 1.00000000001001 1.00050063555831e-11 92 0 0 73 7166 R-RNO-983705 Signaling by the B Cell Receptor (BCR) 1.00000000001013 1.01257805644777e-11 185 0 0 73 7166 R-RNO-156580 Phase II conjugation 1.00000000001043 1.04315460900986e-11 74 0 0 73 7166 R-RNO-2990846 SUMOylation 1.00000000001043 1.04315460900986e-11 74 0 0 73 7166 R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 1.00000000001043 1.04315460900986e-11 74 0 0 73 7166 R-RNO-190236 Signaling by FGFR 1.00000000001043 1.04315460900986e-11 74 0 0 73 7166 R-RNO-199977 ER to Golgi Anterograde Transport 1.00000000001077 1.07750224700235e-11 106 0 0 73 7166 R-RNO-1257604 PIP3 activates AKT signaling 1.00000000001077 1.07750224700235e-11 106 0 0 73 7166 R-RNO-69242 S Phase 1.00000000001088 1.0882445070437e-11 114 0 0 73 7166 R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation 1.00000000001088 1.0882445070437e-11 114 0 0 73 7166 R-RNO-392518 Signal amplification 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-69205 G1/S-Specific Transcription 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-2168880 Scavenging of heme from plasma 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-1482925 Acyl chain remodelling of PG 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-8849932 SALM protein interactions at the synapses 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-1482801 Acyl chain remodelling of PS 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-418038 Nucleotide-like (purinergic) receptors 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-373753 Nephrin interactions 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-202427 Phosphorylation of CD3 and TCR zeta chains 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-456926 Thrombin signalling through proteinase activated receptors (PARs) 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-1251985 Nuclear signaling by ERBB4 1.00000000001132 1.13167593263575e-11 16 0 0 73 7166 R-RNO-1168372 Downstream signaling events of B Cell Receptor (BCR) 1.00000000001185 1.18504070269515e-11 167 0 0 73 7166 R-RNO-68882 Mitotic Anaphase 1.00000000001187 1.18729209409087e-11 145 0 0 73 7166 R-RNO-72312 rRNA processing 1.00000000001213 1.21254814788626e-11 124 0 0 73 7166 R-RNO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.00000000001213 1.21254814788626e-11 124 0 0 73 7166 R-RNO-73857 RNA Polymerase II Transcription 1.00000000001213 1.21254814788626e-11 124 0 0 73 7166 R-RNO-1428517 The citric acid (TCA) cycle and respiratory electron transport 1.00000000001213 1.21254814788626e-11 124 0 0 73 7166 R-RNO-8868773 rRNA processing in the nucleus and cytosol 1.00000000001213 1.21254814788626e-11 124 0 0 73 7166 R-RNO-69306 DNA Replication 1.00000000001272 1.2716196644343e-11 99 0 0 73 7166 R-RNO-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 1.00000000001343 1.34316919619135e-11 62 0 0 73 7166 R-RNO-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 1.00000000001343 1.34316919619135e-11 62 0 0 73 7166 R-RNO-2262749 Cellular response to hypoxia 1.00000000001343 1.34316919619135e-11 62 0 0 73 7166 R-RNO-453279 Mitotic G1-G1/S phases 1.000000000014 1.40021136782934e-11 119 0 0 73 7166 R-RNO-2555396 Mitotic Metaphase and Anaphase 1.00000000001422 1.42160172039657e-11 146 0 0 73 7166 R-RNO-1236975 Antigen processing-Cross presentation 1.00000000001457 1.45650168156597e-11 79 0 0 73 7166 R-RNO-948021 Transport to the Golgi and subsequent modification 1.00000000001607 1.60679781088706e-11 133 0 0 73 7166 R-RNO-2467813 Separation of Sister Chromatids 1.00000000001757 1.75721415748138e-11 139 0 0 73 7166 R-RNO-196854 Metabolism of vitamins and cofactors 1.00000000001757 1.75721415748138e-11 139 0 0 73 7166 R-RNO-68886 M Phase 1.00000000001822 1.82156695405666e-11 200 0 0 73 7166 R-RNO-211859 Biological oxidations 1.00000000001822 1.82156695405666e-11 200 0 0 73 7166 R-RNO-983169 Class I MHC mediated antigen processing & presentation 1.00000000001873 1.87293195224138e-11 160 0 0 73 7166 R-RNO-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1.00000000001983 1.98271779309248e-11 78 0 0 73 7166 R-RNO-453276 Regulation of mitotic cell cycle 1.00000000001983 1.98271779309248e-11 78 0 0 73 7166 R-RNO-72613 Eukaryotic Translation Initiation 1.00000000001983 1.98271779309248e-11 78 0 0 73 7166 R-RNO-72737 Cap-dependent Translation Initiation 1.00000000001983 1.98271779309248e-11 78 0 0 73 7166 R-RNO-5389840 Mitochondrial translation elongation 1.00000000001983 1.98271779309248e-11 78 0 0 73 7166 R-RNO-174143 APC/C-mediated degradation of cell cycle proteins 1.00000000001983 1.98271779309248e-11 78 0 0 73 7166 R-RNO-68867 Assembly of the pre-replicative complex 1.00000000002106 2.10571067405107e-11 63 0 0 73 7166 R-RNO-72689 Formation of a pool of free 40S subunits 1.00000000002106 2.10571067405107e-11 63 0 0 73 7166 R-RNO-72172 mRNA Splicing 1.00000000002111 2.11108286874962e-11 157 0 0 73 7166 R-RNO-6798695 Neutrophil degranulation 1.00000000003375 3.37531541161583e-11 439 0 0 73 7166 R-RNO-381753 Olfactory Signaling Pathway 1.00000000004164 4.16363373016766e-11 558 0 0 73 7166