TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols WP276 Monoamine GPCRs 7.33703070658102e-05 -9.51999124007867 33 5 0.113636363636364 44 3163 24173,24925,25083,24318,24316 Adra1b,Adrb1,Adra2a,Drd2,Drd1 WP326 Calcium Regulation in the Cardiac Cell 0.000667630326732849 -7.31177594070618 144 8 0.181818181818182 44 3163 29480,24925,24173,60449,24246,24679,29481,140448 Rgs4,Adrb1,Adra1b,Gnb3,Camk2d,Prkar2b,Rgs9,Slc8a3 WP473 GPCRs, Class A Rhodopsin-like 0.000729919736063968 -7.22257598046415 223 10 0.227272727272727 44 3163 24925,24173,498289,24318,29335,24316,25083,366274,83683,25706 Adrb1,Adra1b,Opn3,Drd2,Oprk1,Drd1,Adra2a,Ntsr1,Gpr6,Cckbr WP513 Catecholamine synthesis 0.00184195086303589 -6.29693001738111 5 2 0.0454545454545455 44 3163 24311,25085 Ddc,Th WP409 GPCRs, Other 0.00255385638523766 -5.9701507542615 70 5 0.113636363636364 44 3163 60590,171447,25706,366274,64443 Grm8,Adgrl2,Cckbr,Ntsr1,Gpr88 WP378 GPCRs, Class B Secretin-like 0.00321676022070311 -5.73938056856588 22 3 0.0681818181818182 44 3163 64680,171447,58959 Crhr2,Adgrl2,Crhr1 WP140 Myometrial Relaxation and Contraction Pathways 0.00409082456641085 -5.49900872376765 150 7 0.159090909090909 44 3163 24679,24246,60449,29480,58959,29481,497757 Prkar2b,Camk2d,Gnb3,Rgs4,Crhr1,Rgs9,Gucy1a1 WP131 Peptide GPCRs 0.011287784348666 -4.48403416909091 64 4 0.0909090909090909 44 3163 24808,366274,25706,29335 Tacr3,Ntsr1,Cckbr,Oprk1 WP42 GPCRs, Class C Metabotropic glutamate, pheromone 0.0177046031644518 -4.03393060742536 15 2 0.0454545454545455 44 3163 24417,60590 Grm4,Grm8 WP323 Biogenic Amine Synthesis 0.0177046031644518 -4.03393060742536 15 2 0.0454545454545455 44 3163 24311,25085 Ddc,Th WP574 Hedgehog Signaling Pathway 0.0306614587421105 -3.4847488286497 20 2 0.0454545454545455 44 3163 29499,140589 Shh,Gli1 WP1485 Interactions between CFTR and other ion channels 0.0676874593515671 -2.69285435475197 5 1 0.0227272727272727 44 3163 24255 Cftr WP1281 Hypothetical Network for Drug Addiction 0.0681845840604167 -2.68553677985349 31 2 0.0454545454545455 44 3163 24316,24318 Drd1,Drd2 WP155 Adipogenesis 0.100173921609118 -2.30084738758782 128 4 0.0909090909090909 44 3163 84410,29373,362261,114587 Klf5,Bmp2,Lpin3,Dlk1 WP104 Alanine and aspartate metabolism 0.154981841983209 -1.86444731742074 12 1 0.0227272727272727 44 3163 25698 Ass1 WP1488 CFTR activity in the plasma membrane 0.212390847184771 -1.54932708289327 17 1 0.0227272727272727 44 3163 24255 Cftr WP293 Eicosanoid Synthesis 0.223406359811657 -1.49876292448163 18 1 0.0227272727272727 44 3163 81639 Alox15 WP153 Urea cycle and metabolism of amino groups 0.234271262886701 -1.45127559192234 19 1 0.0227272727272727 44 3163 25698 Ass1 WP3901 Lipid Droplet Metabolism 0.29640873186272 -1.21601592626836 25 1 0.0227272727272727 44 3163 362261 Lpin3 WP40 Inflammatory Response Pathway 0.32560142540577 -1.12208126708148 28 1 0.0227272727272727 44 3163 192362 Lamc2 WP73 G Protein Signaling Pathways 0.352826235757185 -1.04177959322328 89 2 0.0454545454545455 44 3163 24679,60449 Prkar2b,Gnb3 WP372 Beta Oxidation Meta Pathway 0.362690132727683 -1.01420643811522 32 1 0.0227272727272727 44 3163 25756 Cpt1b WP1307 Fatty Acid Beta Oxidation 0.380479347613015 -0.966323380123181 34 1 0.0227272727272727 44 3163 25756 Cpt1b WP316 Striated Muscle Contraction 0.397782989213583 -0.921848675634504 36 1 0.0227272727272727 44 3163 296369 Tnnc2 WP520 G13 Signaling Pathway 0.406256781497305 -0.900769852561073 37 1 0.0227272727272727 44 3163 83620 Cit WP2042 PKA-HCG-Glycogen Syntase 0.430985031680886 -0.841681918760151 40 1 0.0227272727272727 44 3163 24246 Camk2d WP270 Tryptophan metabolism 0.484835613171502 -0.723945387412877 47 1 0.0227272727272727 44 3163 24311 Ddc WP397 Id Signaling Pathway 0.506359108706437 -0.680509160412474 50 1 0.0227272727272727 44 3163 29373 Bmp2 WP2562 Relationship between glutathione and NADPH 0.553220291897103 -0.591998998922284 57 1 0.0227272727272727 44 3163 29292 Ftl1 WP1286 Metapathway biotransformation 0.558913586001716 -0.581760404535808 133 2 0.0454545454545455 44 3163 293451,294449 Hs3st2,Hs3st5 WP485 Alpha6-Beta4 Integrin Signaling Pathway 0.559549431352421 -0.58062340597736 58 1 0.0227272727272727 44 3163 192362 Lamc2 WP1290 Apoptosis 0.692153708448268 -0.367947225994845 83 1 0.0227272727272727 44 3163 364081 Irf6 WP2433 Spinal Cord Injury 0.737286233321909 -0.304779085906533 94 1 0.0227272727272727 44 3163 306636 Efnb2 WP375 Wnt Signaling Pathway NetPath 0.75910773095302 -0.275611573644235 100 1 0.0227272727272727 44 3163 24246 Camk2d WP2376 NFE2L2 0.888853386487483 -0.117822976655596 153 1 0.0227272727272727 44 3163 29292 Ftl1 WP188 Focal Adhesion 0.916050700671719 -0.0876835657614697 172 1 0.0227272727272727 44 3163 192362 Lamc2 WP1285 Arachidonate Epoxygenase Epoxide Hydrolase 0.999999999992651 -7.34885402593853e-12 4 0 0 44 3163 WP1303 Polyol pathway 0.999999999992651 -7.34885402593853e-12 4 0 0 44 3163 WP2541 Sulindac Metabolic Pathway 0.999999999992651 -7.34885402593853e-12 4 0 0 44 3163 WP1300 Aflatoxin B1 metabolism 0.999999999992845 -7.15545385735431e-12 6 0 0 44 3163 WP360 Acetylcholine Synthesis 0.999999999992845 -7.15545385735431e-12 6 0 0 44 3163 WP305 Glucocorticoid Metabolism 0.999999999992845 -7.15545385735431e-12 6 0 0 44 3163 WP282 Pentose Phosphate Pathway 0.999999999992845 -7.15545385735431e-12 6 0 0 44 3163 WP1277 Non-homologous end joining 0.999999999992845 -7.15545385735431e-12 6 0 0 44 3163 WP418 Beta Oxidation of Unsaturated Fatty Acids 0.999999999992845 -7.15545385735431e-12 6 0 0 44 3163 WP263 Ovarian Infertility Genes 0.999999999996829 -3.17090796782048e-12 29 0 0 44 3163 WP3887 Angiotensin signaling in thick ascending limbs 0.999999999996829 -3.17090796782048e-12 29 0 0 44 3163 WP1284 EPO Receptor Signaling 0.999999999997199 -2.80098908096138e-12 26 0 0 44 3163 WP347 TCA Cycle 0.999999999997199 -2.80098908096138e-12 26 0 0 44 3163 WP654 ATM Signaling Pathway 0.999999999997199 -2.80098908096138e-12 26 0 0 44 3163 WP656 p53 signal pathway 0.999999999997199 -2.80098908096138e-12 26 0 0 44 3163 WP1968 Genetic alterations of lung cancer 0.999999999997199 -2.80098908096138e-12 26 0 0 44 3163 WP271 Cytokines and Inflammatory Response (BioCarta) 0.999999999997199 -2.80098908096138e-12 26 0 0 44 3163 WP278 Matrix Metalloproteinases 0.999999999997363 -2.63718233673755e-12 28 0 0 44 3163 WP446 MAPK Cascade 0.999999999997363 -2.63718233673755e-12 28 0 0 44 3163 WP349 Synthesis and Degradation of Ketone Bodies 0.99999999999746 -2.53971815447684e-12 5 0 0 44 3163 WP145 Statin Pathway 0.99999999999748 -2.51975853899595e-12 18 0 0 44 3163 WP3894 Fructose Metabolism in Proximal Tubules 0.99999999999748 -2.51975853899595e-12 18 0 0 44 3163 WP487 Apoptosis Modulation by HSP70 0.99999999999748 -2.51975853899595e-12 18 0 0 44 3163 WP1302 Estrogen metabolism 0.99999999999748 -2.51975853899595e-12 18 0 0 44 3163 WP2148 Brain derived neurotrophic factor 0.999999999997949 -2.05062764950959e-12 10 0 0 44 3163 WP227 Osteoblast 0.999999999997949 -2.05062764950959e-12 10 0 0 44 3163 WP66 Steroid Biosynthesis 0.999999999997949 -2.05062764950959e-12 10 0 0 44 3163 WP491 Eukaryotic Transcription Initiation 0.999999999998112 -1.88837635381632e-12 37 0 0 44 3163 WP81 Complement Activation, Classical Pathway 0.99999999999815 -1.84995881162326e-12 14 0 0 44 3163 WP489 Osteoclast 0.99999999999815 -1.84995881162326e-12 14 0 0 44 3163 WP139 Nuclear receptors in lipid metabolism and toxicity 0.999999999998319 -1.68067293536961e-12 32 0 0 44 3163 WP303 Prostaglandin Synthesis and Regulation 0.999999999998319 -1.68067293536961e-12 32 0 0 44 3163 WP557 ACE Inhibitor Pathway 0.999999999998344 -1.65569042394579e-12 9 0 0 44 3163 WP86 Heme Biosynthesis 0.999999999998344 -1.65569042394579e-12 9 0 0 44 3163 WP94 Signaling of Hepatocyte Growth Factor Receptor 0.999999999999113 -8.87233678365185e-13 33 0 0 44 3163 WP160 Glycogen Metabolism 0.999999999999113 -8.87233678365185e-13 33 0 0 44 3163 WP2132 Serotonin and anxiety 0.999999999999168 -8.31887362460428e-13 13 0 0 44 3163 WP1280 Keap1-Nrf2 0.999999999999168 -8.31887362460428e-13 13 0 0 44 3163 WP1964 VEGFR-3 signaling 0.999999999999168 -8.31887362460428e-13 13 0 0 44 3163 WP133 Fatty Acid Omega Oxidation 0.999999999999168 -8.31887362460428e-13 13 0 0 44 3163 WP1292 One Carbon Metabolism 0.999999999999305 -6.94627431962621e-13 25 0 0 44 3163 WP8 IL-9 Signaling Pathway 0.999999999999305 -6.94627431962621e-13 25 0 0 44 3163 WP1965 VEGF-receptor Signal Transduction 0.999999999999305 -6.94627431962621e-13 25 0 0 44 3163 WP1312 Signal Transduction of S1P 0.999999999999542 -4.58391864455479e-13 24 0 0 44 3163 WP1311 Folic Acid Network 0.999999999999542 -4.58391864455479e-13 24 0 0 44 3163 WP3882 Thick Ascending Limb Transporters 0.999999999999542 -4.58170126419139e-13 11 0 0 44 3163 WP337 Glycolysis and Gluconeogenesis 0.999999999999563 -4.3692536099299e-13 42 0 0 44 3163 WP469 Glutathione metabolism 0.999999999999661 -3.39059417645953e-13 21 0 0 44 3163 WP1276 Glucuronidation 0.999999999999661 -3.39059417645953e-13 21 0 0 44 3163 WP124 Irinotecan Pathway 0.999999999999661 -3.39059417645953e-13 21 0 0 44 3163 WP1278 EBV LMP1 signaling 0.999999999999837 -1.63070636016976e-13 16 0 0 44 3163 WP419 Mitochondrial LC-Fatty Acid Beta-Oxidation 0.999999999999837 -1.63070636016976e-13 16 0 0 44 3163 WP3650 Acetate mediated promotion of metabolic syndrome 0.999999999999984 -1.64198895365869e-14 2 0 0 44 3163 WP1287 Amino acid conjugation of benzoic acid 0.999999999999984 -1.64198895365869e-14 2 0 0 44 3163 WP517 Notch Signaling Pathway 1.00000000000021 2.13392780932801e-13 34 0 0 44 3163 WP294 p38 MAPK Signaling Pathway (BioCarta) 1.00000000000021 2.13392780932801e-13 34 0 0 44 3163 WP173 Oxidative Stress 1.00000000000021 2.13392780932801e-13 34 0 0 44 3163 WP1289 Type II interferon signaling (IFNG) 1.00000000000021 2.13392780932801e-13 34 0 0 44 3163 WP1299 ErbB signaling pathway 1.00000000000041 4.11159824882912e-13 46 0 0 44 3163 WP161 Small Ligand GPCRs 1.00000000000056 5.60465543432578e-13 19 0 0 44 3163 WP1301 Mitochondrial Gene Expression 1.00000000000056 5.60465543432578e-13 19 0 0 44 3163 WP504 Fatty Acid Biosynthesis 1.00000000000056 5.60465543432578e-13 19 0 0 44 3163 WP655 p53 pathway 1.00000000000067 6.74431172988167e-13 45 0 0 44 3163 WP1308 Endochondral Ossification 1.00000000000073 7.34063464211873e-13 59 0 0 44 3163 WP302 Proteasome Degradation 1.00000000000073 7.34063464211873e-13 59 0 0 44 3163 WP3649 Wnt myofibroblastic activation of Hepatic Stellate Cells 1.00000000000095 9.50900399257292e-13 3 0 0 44 3163 WP502 Nucleotide GPCRs 1.00000000000106 1.06468584280845e-12 12 0 0 44 3163 WP1296 Homologous recombination 1.00000000000106 1.06468584280845e-12 12 0 0 44 3163 WP147 Kit Receptor Signaling Pathway 1.00000000000109 1.09074885473878e-12 65 0 0 44 3163 WP355 IL-1 Signaling Pathway 1.00000000000112 1.12254056762751e-12 36 0 0 44 3163 WP217 Nuclear Receptors 1.00000000000112 1.12254056762751e-12 36 0 0 44 3163 WP255 Blood Clotting Cascade 1.00000000000119 1.18971461313714e-12 20 0 0 44 3163 WP442 Hypertrophy Model 1.00000000000119 1.18971461313714e-12 20 0 0 44 3163 WP149 Translation Factors 1.00000000000131 1.31043640069814e-12 44 0 0 44 3163 WP590 Cardiovascular Signaling 1.00000000000156 1.56038902726005e-12 35 0 0 44 3163 WP89 FAS pathway and Stress induction of HSP regulation 1.00000000000156 1.56038902726005e-12 35 0 0 44 3163 WP1310 Selenium Micronutrient Network 1.00000000000167 1.66820918309766e-12 22 0 0 44 3163 WP1487 TNF-alpha and mucus production in lung epythelium 1.00000000000202 2.02202459125952e-12 23 0 0 44 3163 WP632 Cholesterol metabolism 1.00000000000202 2.02202459125952e-12 23 0 0 44 3163 WP376 Renin - Angiotensin System 1.00000000000207 2.07374300303788e-12 53 0 0 44 3163 WP44 IL-5 Signaling Pathway 1.00000000000237 2.36963047615846e-12 67 0 0 44 3163 WP1294 NLR Proteins 1.00000000000306 3.05846674032712e-12 8 0 0 44 3163 WP2811 mir219 in Oligodendrocyte Differentiation and Myelination 1.00000000000306 3.05846674032712e-12 8 0 0 44 3163 WP1282 Methylation 1.00000000000306 3.05846674032712e-12 8 0 0 44 3163 WP508 Biosynthesis of Aldosterone and Cortisol 1.0000000000031 3.10163815827792e-12 7 0 0 44 3163 WP1291 Phase I biotransformations, non P450 1.0000000000031 3.10163815827792e-12 7 0 0 44 3163 WP1295 Mismatch repair 1.0000000000031 3.10163815827792e-12 7 0 0 44 3163 WP547 Complement and Coagulation Cascades 1.00000000000327 3.27443566280122e-12 58 0 0 44 3163 WP461 Cholesterol Biosynthesis 1.00000000000341 3.407646675465e-12 15 0 0 44 3163 WP1297 Retinol metabolism 1.00000000000406 4.06051022867311e-12 39 0 0 44 3163 WP146 Nucleotide Metabolism 1.00000000000438 4.38365654825258e-12 17 0 0 44 3163 WP3881 Proximal Tubule Transporters 1.00000000000465 4.64955985021536e-12 55 0 0 44 3163 WP3916 Hexoses metabolism in proximal tubules 1.00000000000465 4.64955985021536e-12 55 0 0 44 3163 WP564 Wnt Signaling Pathway 1.00000000000494 4.93584001911155e-12 56 0 0 44 3163 WP348 G1 to S cell cycle control 1.00000000000585 5.85297739059861e-12 63 0 0 44 3163 WP1279 Estrogen signaling 1.00000000000585 5.85297739059861e-12 63 0 0 44 3163 WP1283 Oxidative phosphorylation 1.000000000006 5.99604653509395e-12 47 0 0 44 3163 WP484 DNA Replication 1.0000000000065 6.49506632244569e-12 40 0 0 44 3163 WP1293 Selenium metabolism Selenoproteins 1.0000000000065 6.49506632244569e-12 40 0 0 44 3163 WP505 TGF Beta Signaling Pathway 1.00000000000687 6.86550613160682e-12 50 0 0 44 3163 WP569 IL-2 Signaling Pathway 1.00000000000714 7.14111209799588e-12 74 0 0 44 3163 WP319 IL-3 Signaling Pathway 1.00000000000769 7.69111723292063e-12 99 0 0 44 3163 WP529 mRNA processing 1.00000000000861 8.60889422887227e-12 116 0 0 44 3163 WP74 Integrin-mediated cell adhesion 1.00000000000874 8.74030729857881e-12 89 0 0 44 3163 WP439 Insulin Signaling 1.00000000000918 9.18377032889265e-12 150 0 0 44 3163 WP59 Electron Transport Chain 1.00000000000956 9.55883295196255e-12 85 0 0 44 3163 WP135 IL-6 Signaling Pathway 1.00000000000958 9.58426451209312e-12 97 0 0 44 3163 WP1309 Toll-like receptor signaling pathway 1.00000000000978 9.78462986024837e-12 88 0 0 44 3163 WP1288 Wnt Signaling Pathway and Pluripotency 1.00000000000978 9.78462986024837e-12 88 0 0 44 3163 WP429 Cell cycle 1.00000000001054 1.05448886631865e-11 81 0 0 44 3163 WP199 Delta-Notch Signaling Pathway 1.00000000001101 1.10095910142493e-11 73 0 0 44 3163 WP30 Cytoplasmic Ribosomal Proteins 1.00000000001138 1.13796748803914e-11 76 0 0 44 3163 WP351 Regulation of Actin Cytoskeleton 1.00000000001199 1.19875151132394e-11 142 0 0 44 3163 WP5 EGFR1 Signaling Pathway 1.00000000001629 1.62852258953884e-11 167 0 0 44 3163 WP457 TNF-alpha NF-kB Signaling Pathway 1.00000000001716 1.71623998187874e-11 166 0 0 44 3163 WP358 MAPK signaling pathway 1.00000000001727 1.72656739829026e-11 153 0 0 44 3163