TermID |Term |Enrichment |logP |Genes in Term|Target Genes in Term|Fraction of Targets in Term|Total Target Genes|Total Genes|Gene Symbols :---------|:----------------------------------------------------------------------|:-------------------|:----------------|:------------|:-------------------|:--------------------------|:-----------------|:----------|:---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- hsa01100 |Metabolic pathways |7.66418923974478e-13|-27.8970474765254|1256 |680 |0.210722032847846 |3227 |7161 |CYP19A1,PTGES,AANAT,AGMAT,PIGY,AKR1B1,ME3,CEPT1,TWISTNB,PTS,CYP2R1,TPK1,GCNT1,PON2,PSPH,MBOAT1,PIK3C2B,MDH1,LAMA3,SMS,GCLC,MAT1A,AK9,CHIT1,ASS1,FDFT1,HKDC1,GPAT3,LPIN3,NDUFS1,CD38,NT5M,EXTL3,XDH,ACSBG2,MTMR14,SELENOI,CYP24A1,ACSL4,URAD,POLG,IDO2,ATP6V1C1,GNE,MLYCD,ST6GALNAC1,ITPKC,FDPS,MVK,PI4K2A,COQ2,FBP1,HMOX1,DGKZ,GK,KYNU,PGD,SORD,UPB1,DCTPP1,ALDH1A3,UGT1A5,POMGNT2,MDH2,POLR3GL,CPS1,COASY,PSAT1,CES1,ACSL6,ATP6V1E2,NDUFB3,B3GNT5,SLC33A1,ATP5F1A,AOC3,PGLS,ACSM1,CDS2,GGPS1,MTAP,PAPSS1,FPGS,HMGCL,FECH,DCK,CYP27B1,PCYT1A,DGKQ,BLVRA,CPOX,ATP6V0C,GADL1,IMPA2,AK5,ATP5MG,PCK1,BLVRB,HIBADH,ACER1,ARG1,SDHB,PCCB,COX5A,GAMT,CRLS1,RDH16,UXS1,SAT1,HK2,DHCR24,BAAT,ALDOB,ACER2,GALNT17,COMT,ACACB,GPHN,GLCE,ACACA,GATM,COX8A,ENPP1,UCK1,PLPP3,CYP11B2,POLE4,ENOPH1,UPP2,TBXAS1,PGM2,SCLY,UGT2B15,LIPC,TAT,TST,PRODH2,CYP2C18,PLA2G4C,GLDC,CYP8B1,NDUFA4,APRT,ABAT,PIGN,POLE3,GFPT2,ADPGK,GPT,DGKE,UQCRB,ITPA,SDSL,AGXT2,COX6B1,PAPSS2,UGT2B4,SYNJ2,AKR1C3,BCAT2,IDH3A,PIP5K1A,BPGM,DGKA,NFS1,MGAT5,MAOB,POLR3B,TM7SF2,PLA2G2A,UROC1,PLCH2,ALAD,NSDHL,IDI1,CYCS,GPAT4,HSD17B6,AZIN2,SHMT2,IMPDH1,PRIM2,CYP3A7-CYP3A51P,UQCRC2,MGAM2,ETNPPL,PLD1,UQCRC1,GFPT1,DSE,ACO2,MAN2A1,GALT,HADH,DEGS2,GALNT11,CTH,DHRS3,KDSR,ALDH2,ITPK1,ATP6V1G1,GBA,SCP2,BCKDHB,FCSK,HAAO,NADK2,GOT1,ATP5MC3,PANK3,TRIT1,DPYS,RPEL1,ATP6V0D1,ATP5PF,GCK,ETNK2,ALDH5A1,MTHFD1L,ALG9,XYLT2,ASL,ACAT2,POMK,NDUFS5,GRHPR,ACOT1,DMGDH,SPHK2,ARSB,PLA2G1B,SLC27A5,DGKD,CYP2C9,PLB1,FAH,GPT2,MOCS1,DGAT1,ACOX3,GOT2,IMPDH2,MTM1,HEXB,PCYT1B,EXT1,G6PC2,PYGB,CKB,PHYKPL,ATP6V0D2,ST3GAL6,PGAP1,RDH12,PGK1,SARDH,HOGA1,SGPL1,CSGALNACT1,B4GALNT3,HPGDS,CHST9,KHK,FUT9,UGDH,DCT,ATP6V0E1,CNDP1,CERS4,GCLM,ASMT,UQCRHL,ATP5MC1,PYCR1,HADHA,PKM,SPHK1,ALAS1,NMNAT1,A4GALT,GBE1,PIP5K1B,CYP1A1,GUSB,HMGCR,GGT1,ALDH3A2,PLA2G4E,MAN1C1,NME1-NME2,MOGS,AGPAT2,GCH1,MAT2A,HSD17B2,AFMID,HDC,RPN1,ACSL1,SMPD1,PDXK,AK2,ALG13,GLYCTK,ATP6V1C2,PIGC,AGXT,CRYL1,TRAK2,UGT1A4,ADH4,ENPP7,G6PC3,GCNT2,CS,PDHX,TK2,CHSY1,ADK,GMDS,NDUFS7,DDC,FUT1,HSD17B4,PIK3C2A,RRM1,DNMT1,ALG2,B3GNT2,SGMS1,CTPS1,POLD2,DLST,ALOX15B,PLCB1,UAP1,NAGLU,AGPAT4,AKR1D1,POLR3H,NDUFB7,ADSS,COX5B,P4HA1,SPR,CHDH,ST3GAL4,MAN1A2,ALG8,ALDH7A1,INPP4A,RDH11,ATP6V1D,ADH6,RRM2B,QDPR,COQ5,NT5C3A,PISD,SC5D,B3GAT2,PI4KA,PGM3,NDUFA8,UROD,MTMR3,PGS1,HADHB,MTHFD2,IDNK,GYG1,UGT2A3,GDA,C1GALT1,ACSS3,UGT2B7,PLCD3,NDUFAB1,PIK3C3,UPP1,ACSL5,LTA4H,PLCH1,KL,HYAL3,NDUFA11,PANK2,ETNK1,PMM1,GCNT3,IDH1,ITPKB,CSAD,CYP2A6,CYP26B1,PIGU,MAN1A1,POLR2D,ALLC,MCEE,DGKI,PDXP,PHGDH,DHCR7,PIPOX,ACP1,DGKK,FLAD1,CERS6,ALDH4A1,HSD17B1,TALDO1,EPHX2,PCK2,CHST10,CYP2J2,ALDOA,GALNT10,DPM1,HMGCS2,ATP6V0A4,ACSM2A,GALNT13,ALPP,MSMO1,GALNT2,GALM,LPIN1,MGAT1,FAXDC2,POLR3A,PIGA,ATP5PO,EPRS,OAT,LIPG,NDUFS4,LCLAT1,SEPHS1,PHOSPHO2,GLB1,HMGCLL1,OCRL,ACAA1,ACMSD,AOX1,RIMKLB,CDIPT,CERS2,ALPL,ACLY,AGPS,DCTD,ACSM2B,PTGIS,ALG10,SPTLC3,NDUFA12,ACSS2,RPN2,PNMT,DHRS4L2,ST6GALNAC4,ADA2,COX4I2,DGUOK,INPP5A,LPCAT1,RPIA,UQCR10,MTMR7,B3GNT4,GPI,G6PC,ATP5F1D,COX4I1,CYP51A1,GLS2,FUT7,PI4KB,THTPA,ALDH3B1,AMD1,GMPPB,ACSBG1,PAH,UGT2B10,MTHFD2L,ASNS,DHFR,AMDHD1,LAMA5,PIK3C2G,CYP3A4,NDST2,EXTL1,HMBS,GYS1,IVD,ADH5,GCSH,B3GALT1,PNP,HSD17B7,MMAB,RPE,NADK,ACSS1,INPP5B,DNMT3A,NMNAT2,CYP26A1,UGP2,POLR2E,POLR2A,ADSSL1,AADAT,GALNT4,TUSC3,NDST1,UCK2,MTMR4,STT3B,ACOX1,ALDH18A1,PLCG2,GBGT1,CYP2B6,NDUFV2,GALNT12,SUCLG1,ACADVL,NDUFC1,DBT,MGAT4A,DNMT3B,RDH10,B3GALT6,PFAS,AMACR,NT5E,ST3GAL5,MGLL,PAFAH2,ACO1,HGSNAT,FASN,ADH7,ALDH1A1,COQ7,DHODH,EARS2,ENPP3,PFKP,DAD1,MAT2B,GGT5,SPTLC2,AGPAT3,POLG2,CYP26C1,ST3GAL2,DEGS1,ACADL,GUK1,SEPHS2,CYP27A1,OTC,LARGE1,LDHAL6B,GSS,GLS,GPAT2,GALE,CYP4F3,FAHD1,B4GALT2,ATP6V0A1,PYGL,CHPT1,OGDH,DOLK,ACADSB,MTMR2,PYCR2,AASS,UMPS,NDUFB6,FUT5,CHKA,NT5C2,INPP1,LDHA,LAP3,PFKL,ANPEP,AHCYL1,DHRS4,GALNT14,COX11,B3GAT3,ISYNA1,HAL,PGM1,RFK,SGMS2,NDUFB11,HGD,KYAT1,NANS,ADI1,PPCDC,COQ6,PGK2,TSTA3,AHCY,HPD,NOS1,AGPAT1,PLPP1,ZNRD1,GAPDH,PLCB4,PEMT,ATP5MC2,ST3GAL1,PIGF,NDUFB9,ALDH1A2,GALNT15,SUCLG2,GPAM,H6PD,IDH2,PIGX,ACOT2,ALDH1B1,MTR,ACOX2,HLCS,COX6C,ATP6V1G2,PRDX6,GYS2,MAOA,ACADS,PANK1,CYP2C8,COX6A1,ACSL3,P4HA3,POLR1D,NDUFB4,ASAH2,PNPLA2,UQCRFS1,CNDP2,BCAT1,PNPO,POLR1E,TPH2,RGN,DHRS4L1,LPIN2,PNPLA3,BTD,ALOX15,KYAT3,ST6GAL1,TYMP,AHCYL2,MTHFR,ATP5ME,CYP2S1,GANC,NTPCR,ATP5F1C,AKR1A1,PLA2G6 hsa04931 |Insulin resistance |1.26347863392011e-08|-18.1868120064826|107 |77 |0.0238611713665944 |3227 |7161 |RPS6KA3,INSR,OGT,IRS1,ACACB,PPP1CB,CPT1A,TRIB3,CREB3L2,PRKCD,NR1H3,NFKB1,CREB3L3,TNFRSF1A,CRTC2,OGA,NR1H2,CREB3L4,SLC2A4,PPP1R3E,SLC2A1,RPS6KA2,PCK1,MLXIP,SLC27A1,MLX,SLC27A4,GFPT1,CREB3,PTPN11,PRKAA1,SOCS3,PRKCZ,GSK3B,PRKAB1,PYGL,RPS6KB2,MLXIPL,PCK2,PRKAG2,PIK3R3,CREB1,PRKAB2,MTOR,PPARGC1B,NFKBIA,CREB5,PPP1CC,PRKCE,PRKAG1,G6PC2,GYS1,PYGB,RPS6KA1,SLC2A2,CD36,PTPA,G6PC,SLC27A2,GYS2,PTPN1,PIK3CB,SREBF1,PPARA,SLC27A5,AKT3,PPP1R3C,TBC1D4,PDPK1,CREB3L1,G6PC3,PTPRF,STAT3,GFPT2,PPARGC1A,PIK3R1,PIK3R2 hsa04216 |Ferroptosis |1.19240719149766e-06|-13.6395364440489|40 |33 |0.010226216299969 |3227 |7161 |ACSL4,ACSL1,CP,SLC11A2,FTL,FTH1,SLC39A14,SLC3A2,PRNP,ACSL3,GCLM,HMOX1,SAT1,MAP1LC3B,VDAC2,ACSL5,TF,GSS,GCLC,PCBP2,PCBP1,ALOX15,GPX4,SLC40A1,ACSL6,VDAC3,SLC7A11,ATG5,NCOA4,STEAP3,MAP1LC3A,ATG7,TFRC ko04216 |Ferroptosis |1.19240719149766e-06|-13.6395364440489|40 |33 |0.010226216299969 |3227 |7161 |FTL,SLC11A2,SLC3A2,SLC39A14,FTH1,ACSL4,ACSL1,CP,MAP1LC3B,SAT1,ACSL3,PRNP,GCLM,HMOX1,ALOX15,SLC40A1,GPX4,ACSL6,NCOA4,VDAC3,ATG5,SLC7A11,ACSL5,VDAC2,PCBP1,PCBP2,GCLC,TF,GSS,TFRC,STEAP3,ATG7,MAP1LC3A ko04146 |Peroxisome |2.88497246666962e-05|-10.4534101086711|83 |56 |0.017353579175705 |3227 |7161 |MVK,ACSL3,DECR2,ABCD3,PEX14,PEX11G,ACAA1,HMGCLL1,EPHX2,MPV17L2,NUDT7,ACSL1,PRDX1,ACSL4,DHRS4,SLC27A2,AGXT,GNPAT,PXMP4,PIPOX,MLYCD,IDH1,NUDT19,SCP2,PEX19,PEX3,ECH1,PECR,PEX16,IDH2,CAT,PRDX5,AMACR,XDH,ACOX2,HMGCL,SOD2,ACOX1,CRAT,MPV17L,MPV17,PEX6,AGPS,ACSL5,HSD17B4,BAAT,DHRS4L1,ACOX3,FAR1,ABCD1,ACSL6,ECI2,SLC25A17,PEX26,PHYH,SOD1 hsa04146 |Peroxisome |2.88497246666962e-05|-10.4534101086711|83 |56 |0.017353579175705 |3227 |7161 |HMGCL,ACOX2,SOD2,AMACR,XDH,PEX3,PECR,ECH1,PEX16,IDH2,CAT,PRDX5,NUDT19,IDH1,SCP2,PEX19,SLC25A17,SOD1,PHYH,PEX26,ACOX3,FAR1,ABCD1,ECI2,ACSL6,CRAT,ACOX1,MPV17L,MPV17,PEX6,AGPS,HSD17B4,ACSL5,BAAT,DHRS4L1,EPHX2,ACAA1,HMGCLL1,PEX14,PEX11G,MVK,DECR2,ABCD3,ACSL3,PXMP4,PIPOX,MLYCD,AGXT,GNPAT,ACSL4,PRDX1,ACSL1,DHRS4,SLC27A2,MPV17L2,NUDT7 ko04152 |AMPK signaling pathway |3.74692779385059e-05|-10.1919892157338|120 |76 |0.0235512860241711 |3227 |7161 |PPP2R1B,CREB5,CCND1,GYS1,PRKAG1,G6PC2,LEPR,AKT1S1,RPS6KB2,CAB39,PRKAB1,PPP2R3B,PRKAB2,PIK3R3,CREB1,MTOR,PRKAG2,PCK2,ADRA1A,HNF4A,TBC1D1,STRADA,PDPK1,LIPE,AKT3,SIRT1,ADIPOR2,PPP2R5A,PPARGC1A,PIK3R2,PIK3R1,RPTOR,FBP1,G6PC3,CREB3L1,LEP,PFKP,MLYCD,CD36,RAB2A,PPARG,RHEB,GYS2,SREBF1,PIK3CB,RAB10,G6PC,FASN,EEF2K,PPP2R2C,CREB3L2,RAB14,PPP2R2D,CRTC2,HMGCR,CREB3L3,INSR,ACACA,FOXO3,CPT1A,TSC2,ACACB,PPP2R2A,IRS1,CREB3,PPP2CA,PRKAA1,ADIPOR1,EIF4EBP1,PCK1,EEF2,IGF1,SLC2A4,CREB3L4,CCNA2,PFKL hsa04152 |AMPK signaling pathway |3.74692779385059e-05|-10.1919892157338|120 |76 |0.0235512860241711 |3227 |7161 |PFKP,MLYCD,CD36,RAB2A,PPARG,RHEB,GYS2,SREBF1,PIK3CB,G6PC,RAB10,EEF2K,FASN,PDPK1,LIPE,AKT3,SIRT1,PIK3R1,ADIPOR2,PPARGC1A,PIK3R2,PPP2R5A,RPTOR,FBP1,LEP,CREB3L1,G6PC3,AKT1S1,RPS6KB2,CAB39,PRKAB1,PPP2R3B,CREB1,PRKAB2,PIK3R3,MTOR,PRKAG2,HNF4A,PCK2,ADRA1A,TBC1D1,STRADA,PPP2R1B,CREB5,CCND1,G6PC2,GYS1,PRKAG1,LEPR,PCK1,EEF2,IGF1,SLC2A4,CREB3L4,CCNA2,PFKL,CREB3,PPP2CA,ADIPOR1,PRKAA1,EIF4EBP1,INSR,ACACA,FOXO3,CPT1A,TSC2,ACACB,PPP2R2A,IRS1,CREB3L2,PPP2R2C,RAB14,PPP2R2D,CRTC2,HMGCR,CREB3L3 hsa04810 |Regulation of actin cytoskeleton |0.0001078235201735 |-9.13501473986027|211 |122 |0.037806011775643 |3227 |7161 |ENAH,VCL,PAK3,RHOA,PDGFC,PIK3R3,ITGA1,CYFIP2,FGF2,PDGFRA,ITGA7,ARHGEF1,ITGAE,ARHGEF4,ARPC2,ARPC1A,ITGB2,PIP5K1A,PIP4K2A,BRAF,FGF21,SPATA13,ITGAL,PTK2,ITGA6,IQGAP3,FGFR1,PFN1,MYL10,PPP1CC,FGF1,BCAR1,PIK3CB,ITGB5,CFL2,PAK4,RRAS2,LIMK2,RAF1,PFN2,CD14,MYLK4,ABI2,DOCK1,ACTB,PIK3R1,BDKRB2,PIK3R2,CYFIP1,ARPC5L,KRAS,ACTN1,MYL12B,CHRM5,MYH9,ARHGAP35,SSH3,CRKL,GNA12,MYH10,SRC,PPP1CB,ROCK1,ARHGEF6,PAK1,IQGAP1,VAV2,ITGAD,MYH14,ARHGEF7,DIAPH1,PIP5K1B,SLC9A1,MYLK,CRK,FGFR2,CDC42,FGF10,EGF,ITGA2,ARPC5,FGF3,PXN,IQGAP2,ARHGEF12,NRAS,ARPC1B,PDGFA,RDX,MRAS,PPP1R12B,MAPK1,ITGAX,PAK2,NCKAP1,FGF20,FGF14,PDGFRB,FGF19,F2,MYLK3,SSH2,ITGB3,FGF9,WASF2,MAP2K1,FGFR4,VAV3,FGFR3,MYL9,ACTG1,FN1,BDKRB1,ITGAM,ITGB1,PIKFYVE,WASF1,ACTN4,WASL,SOS1,GSN,ROCK2 ko04810 |Regulation of actin cytoskeleton |0.0001078235201735 |-9.13501473986027|211 |122 |0.037806011775643 |3227 |7161 |SSH2,ITGB3,WASF2,FGF9,PDGFRB,FGF19,FGF14,F2,MYLK3,PAK2,NCKAP1,FGF20,PPP1R12B,MAPK1,ITGAX,GSN,SOS1,ROCK2,FN1,BDKRB1,ITGAM,ITGB1,PIKFYVE,WASF1,WASL,ACTN4,FGFR3,MYL9,ACTG1,MAP2K1,VAV3,FGFR4,CDC42,FGF10,EGF,PIP5K1B,DIAPH1,SLC9A1,CRK,MYLK,FGFR2,VAV2,PAK1,IQGAP1,ITGAD,ARHGEF7,MYH14,GNA12,SRC,MYH10,ROCK1,ARHGEF6,PPP1CB,NRAS,ARPC1B,MRAS,RDX,PDGFA,ARHGEF12,PXN,IQGAP2,ARPC5,ITGA2,FGF3,PFN2,MYLK4,CD14,DOCK1,ACTB,ABI2,RRAS2,LIMK2,RAF1,PAK4,PIK3CB,ITGB5,CFL2,ARHGAP35,CRKL,SSH3,MYL12B,CHRM5,MYH9,ARPC5L,KRAS,ACTN1,PIK3R1,BDKRB2,CYFIP1,PIK3R2,PDGFRA,ITGA7,ARHGEF1,ITGA1,CYFIP2,FGF2,ENAH,PAK3,VCL,PDGFC,RHOA,PIK3R3,ITGAL,PTK2,IQGAP3,ITGA6,MYL10,PFN1,FGFR1,FGF1,PPP1CC,BCAR1,BRAF,PIP4K2A,SPATA13,FGF21,ARHGEF4,ARPC1A,ARPC2,ITGB2,PIP5K1A,ITGAE hsa04910 |Insulin signaling pathway |0.000231443802847161|-8.37117346618717|138 |83 |0.0257204834211342 |3227 |7161 |SLC2A4,PCK1,PPP1R3E,PRKAR1A,MAPK1,CBLB,SOS1,SORBS1,PDE3B,HK2,EIF4E,RHOQ,PRKAA1,EXOC7,EIF4EBP1,GSK3B,PRKCZ,SOCS3,MAP2K1,ACACA,CRK,INSR,HKDC1,IRS1,CALM2,PPP1CB,TSC2,ACACB,EIF4E2,MKNK2,PHKB,NRAS,CALM1,SOCS2,GCK,RHEB,RAF1,FASN,SHC3,PTPN1,GYS2,PIK3CB,SREBF1,G6PC,PPP1R3C,LIPE,CRKL,AKT3,PRKCI,PDPK1,RPTOR,PTPRF,SH2B2,FLOT2,KRAS,FBP1,G6PC3,PIK3R2,PPARGC1A,PIK3R1,PRKAB1,PYGL,RPS6KB2,SOCS1,PCK2,SHC1,PIK3R3,PRKAB2,MTOR,RAPGEF1,SHC4,PRKAG2,PRKACA,PPP1CC,GRB2,CALML5,BRAF,G6PC2,GYS1,PRKAG1,PYGB,PPP1R3F,TRIP10 ko04910 |Insulin signaling pathway |0.000231443802847161|-8.37117346618717|138 |83 |0.0257204834211342 |3227 |7161 |KRAS,FBP1,G6PC3,SH2B2,RPTOR,PTPRF,FLOT2,PIK3R1,PPARGC1A,PIK3R2,AKT3,PPP1R3C,CRKL,LIPE,PDPK1,PRKCI,SHC3,FASN,G6PC,GYS2,PTPN1,PIK3CB,SREBF1,RHEB,GCK,RAF1,TRIP10,G6PC2,GYS1,PRKAG1,PYGB,PPP1R3F,PPP1CC,PRKACA,GRB2,CALML5,BRAF,PCK2,SHC1,PRKAG2,SHC4,PIK3R3,PRKAB2,MTOR,RAPGEF1,PRKAB1,PYGL,RPS6KB2,SOCS1,PRKAA1,EXOC7,EIF4EBP1,SOCS3,MAP2K1,PRKCZ,GSK3B,PDE3B,SORBS1,SOS1,HK2,RHOQ,EIF4E,MAPK1,CBLB,PRKAR1A,SLC2A4,PPP1R3E,PCK1,CALM1,SOCS2,NRAS,PHKB,IRS1,CALM2,ACACB,EIF4E2,MKNK2,PPP1CB,TSC2,ACACA,HKDC1,CRK,INSR hsa04068 |FoxO signaling pathway |0.000404172668157203|-7.81366837488224|132 |79 |0.024480942051441 |3227 |7161 |SIRT1,PIK3R2,PIK3R1,KRAS,G6PC3,TGFB3,STAT3,GADD45G,PDPK1,AKT3,NLK,FASLG,BCL2L11,G6PC,PIK3CB,SGK3,GABARAPL1,USP7,SGK1,RAF1,CDKN2B,CCND1,G6PC2,PRKAG1,TGFBR2,EP300,BRAF,PLK4,GRB2,PRKAG2,SMAD3,PIK3R3,PRKAB2,MAPK13,GABARAPL2,CDKN1A,PCK2,MDM2,GADD45B,FOXO6,PLK3,CCNG2,PRKAB1,SGK2,MAP2K1,ATM,RBL2,PRKAA1,CDKN2D,MAPK14,TNFSF10,SOS1,STK4,CREBBP,MAPK1,FBXO32,KLF2,SKP2,SETD7,BCL6,PCK1,SLC2A4,PRMT1,HOMER3,HOMER1,CSNK1E,IL7R,IGF1,CAT,SMAD4,SOD2,PLK1,NRAS,BNIP3,IRS1,GADD45A,INSR,FOXO3,EGF hsa04141 |Protein processing in endoplasmic reticulum |0.00042128590102221 |-7.7721988549506 |165 |96 |0.0297489928726371 |3227 |7161 |TXNDC5,SSR3,SAR1B,DDIT3,SEL1L,RNF185,PPP1R15A,UBE2D1,HSPH1,XBP1,P4HB,EDEM2,MAN1A1,HSPA8,OS9,RPN1,NPLOC4,MARCH6,HSP90AB1,ERN1,SEC24A,UBE2J2,DNAJB12,MAP3K5,CANX,DAD1,UBE2D4,CAPN1,SVIP,HSPA6,HSPA5,CUL1,SIL1,NFE2L2,MAN1A2,DNAJC10,UBE2G1,UBE2D3,MAP2K7,SELENOS,AMFR,DNAJA1,SEC61G,RAD23B,SEC23A,CAPN2,HSPA1B,DERL1,BCAP31,MBTPS2,SEC24D,SEC62,SEC61A1,UBE2J1,WFS1,ATF4,DNAJC5,BCL2,TRAF2,STT3B,EDEM1,RRBP1,SEC63,DNAJA2,TUSC3,RAD23A,FBXO6,SKP1,HSPA1A,ATF6,PDIA4,HERPUD1,ERLEC1,SYVN1,SEC13,RPN2,CKAP4,UBE2G2,HSP90AA1,DNAJB1,HSPA4L,UGGT1,TRAM1,DNAJC5B,LMAN1,DNAJC3,DNAJB11,MBTPS1,HYOU1,ERP29,MAN1C1,MOGS,UBE4B,SEC23B,NSFL1C,EIF2AK3 ko04141 |Protein processing in endoplasmic reticulum |0.00042128590102221 |-7.7721988549506 |165 |96 |0.0297489928726371 |3227 |7161 |HSPA6,SVIP,CAPN1,SEC23A,CAPN2,RAD23B,AMFR,SEC61G,DNAJA1,SELENOS,MAP2K7,DNAJC10,UBE2G1,UBE2D3,MAN1A2,HSPA5,CUL1,SIL1,NFE2L2,NPLOC4,MARCH6,EDEM2,MAN1A1,HSPA8,OS9,RPN1,XBP1,P4HB,UBE2D1,PPP1R15A,HSPH1,SEL1L,RNF185,DDIT3,TXNDC5,SSR3,SAR1B,DAD1,CANX,UBE2D4,MAP3K5,ERN1,UBE2J2,DNAJB12,SEC24A,HSP90AB1,UGGT1,DNAJB1,HSPA4L,HSP90AA1,UBE2G2,CKAP4,RPN2,SYVN1,SEC13,EIF2AK3,NSFL1C,SEC23B,MOGS,UBE4B,MAN1C1,HYOU1,ERP29,DNAJB11,MBTPS1,DNAJC3,TRAM1,LMAN1,DNAJC5B,TRAF2,BCL2,ATF4,DNAJC5,UBE2J1,WFS1,SEC62,SEC61A1,SEC24D,BCAP31,DERL1,MBTPS2,HSPA1B,ATF6,PDIA4,ERLEC1,HERPUD1,HSPA1A,DNAJA2,SEC63,TUSC3,RAD23A,FBXO6,SKP1,STT3B,EDEM1,RRBP1 hsa04915 |Estrogen signaling pathway |0.000426823337807636|-7.75914035913276|98 |61 |0.0189030058878215 |3227 |7161 |GNAI1,CREB3L3,GNAS,CALM1,PRKCD,CREB5,NRAS,ESR1,CREB3L2,CALML5,GRB2,PRKACA,SHC4,SRC,HSPA6,ADCY7,HSP90AA1,CREB1,PIK3R3,CALM2,PLCB4,FKBP5,SHC1,ADCY4,PLCB1,HBEGF,ITPR3,MAP2K1,GNAI3,GNAI2,ITPR2,PIK3R1,PIK3R2,MMP2,ADCY9,JUN,CREB3L1,KRAS,ADCY8,HSPA1A,ADCY3,GPER1,CREB3,HSP90AB1,FOS,OPRM1,MMP9,AKT3,SOS1,ATF4,MAPK1,PIK3CB,SHC3,ADCY1,HSPA8,ITPR1,KCNJ3,RAF1,HSPA1B,GABBR2,CREB3L4 ko04915 |Estrogen signaling pathway |0.000426823337807636|-7.75914035913276|98 |61 |0.0189030058878215 |3227 |7161 |HSPA8,ITPR1,ADCY1,KCNJ3,SHC3,PIK3CB,ATF4,MAPK1,GABBR2,CREB3L4,RAF1,HSPA1B,HSPA1A,ADCY8,ADCY3,CREB3L1,KRAS,PIK3R2,PIK3R1,JUN,ADCY9,MMP2,GNAI3,MAP2K1,GNAI2,ITPR2,SOS1,MMP9,OPRM1,AKT3,CREB3,FOS,HSP90AB1,GPER1,SHC1,ADCY4,CALM2,PLCB4,FKBP5,HSPA6,ADCY7,SRC,HSP90AA1,CREB1,PIK3R3,SHC4,ITPR3,PLCB1,HBEGF,GNAS,CALM1,CREB3L3,GNAI1,CALML5,PRKACA,GRB2,CREB5,CREB3L2,ESR1,NRAS,PRKCD hsa04922 |Glucagon signaling pathway |0.000468846145647563|-7.66523589099718|102 |63 |0.0195227765726681 |3227 |7161 |GYS2,ATF4,G6PC,PFKL,ITPR1,CAMK2G,SIK2,PCK1,SLC2A1,GCK,SLC2A2,PRMT1,CREB3L4,PPARGC1A,SIRT1,ITPR2,PPP4R3B,PRKAA1,CREB3L1,G6PC3,PPP3CA,FBP1,PKM,CREB3,PDE3B,CREBBP,AKT3,PPARA,CAMK2B,PRKAB2,CPT1A,CREB1,PRKAG2,ACACB,CAMK2A,PCK2,PPP4C,GCGR,CALM2,PLCB4,LDHAL6B,PYGL,ITPR3,ACACA,PPP4R3A,PLCB1,PRKAB1,CAMK2D,CRTC2,GNAS,PYGB,CALM1,G6PC2,GYS1,PRKAG1,CREB3L3,LDHA,EP300,PHKB,CALML5,PRKACA,CREB5,CREB3L2 ko04922 |Glucagon signaling pathway |0.000468846145647563|-7.66523589099718|102 |63 |0.0195227765726681 |3227 |7161 |PYGL,PLCB1,PPP4R3A,PRKAB1,ACACA,ITPR3,PRKAG2,ACACB,CAMK2B,PRKAB2,CREB1,CPT1A,PLCB4,CALM2,GCGR,LDHAL6B,CAMK2A,PCK2,PPP4C,LDHA,EP300,CREB5,CREB3L2,PHKB,CALML5,PRKACA,CRTC2,CAMK2D,CREB3L3,PYGB,GNAS,PRKAG1,GYS1,CALM1,G6PC2,SLC2A1,PCK1,GCK,CREB3L4,SLC2A2,PRMT1,G6PC,ATF4,GYS2,CAMK2G,SIK2,PFKL,ITPR1,PKM,CREB3,AKT3,PPARA,PDE3B,CREBBP,ITPR2,PPARGC1A,SIRT1,G6PC3,PPP3CA,CREB3L1,FBP1,PRKAA1,PPP4R3B hsa04211 |Longevity regulating pathway |0.000490541444160932|-7.62000078882604|89 |56 |0.017353579175705 |3227 |7161 |NRAS,CREB3L2,CREB5,PRKACA,SOD2,NFKB1,CREB3L3,CAMK4,PRKAG1,CAT,FOXO3,PRKAB1,ATG5,RPS6KB2,AKT1S1,INSR,IRS1,ADCY4,PRKAG2,KL,EIF4E2,PRKAB2,PIK3R3,CREB1,MTOR,TSC2,ADCY7,AKT3,SESN2,EIF4E,CREB3,KRAS,CREB3L1,EIF4EBP1,RPTOR,ADIPOR1,PRKAA1,ATG13,ADCY8,ADCY3,SESN3,EHMT1,SIRT1,ADCY9,ADIPOR2,PIK3R2,PIK3R1,PPARGC1A,CREB3L4,PPARG,RHEB,IGF1,ADCY1,SESN1,ATF4,PIK3CB hsa04668 |TNF signaling pathway |0.000530909438855099|-7.54091909956283|108 |66 |0.020452432599938 |3227 |7161 |CSF1,NOD2,MMP14,CXCL5,CASP8,CXCL2,SELE,BCL3,NFKB1,CREB3L2,CX3CL1,TNFRSF1A,CREB3L3,PGAM5,CREB3L4,MAPK1,ATF4,BIRC3,TRAF2,CCL20,MAPK14,FAS,CREB3,MMP9,SOCS3,MAP2K1,IL15,JUN,IKBKG,CFLAR,EDN1,TAB2,CREB1,PIK3R3,MAP3K14,MAPK13,TAB1,ICAM1,RIPK1,BIRC2,JUNB,NFKBIA,JAG1,CREB5,MAP2K7,ITCH,MAP2K6,IL1B,MAP2K3,PIK3CB,TRAF1,BAG4,DAB2IP,TRAF3,CEBPB,CASP10,FOS,MLKL,AKT3,MAP3K8,TAB3,MAP3K5,PIK3R2,PIK3R1,DNM1L,CREB3L1 ko04668 |TNF signaling pathway |0.000530909438855099|-7.54091909956283|108 |66 |0.020452432599938 |3227 |7161 |BCL3,NFKB1,CREB3L2,CX3CL1,TNFRSF1A,CREB3L3,PGAM5,CSF1,NOD2,MMP14,CXCL5,CXCL2,CASP8,SELE,FAS,CREB3,MAPK14,MMP9,JUN,SOCS3,MAP2K1,IL15,IKBKG,CREB3L4,MAPK1,ATF4,CCL20,TRAF2,BIRC3,NFKBIA,JUNB,CREB5,JAG1,MAP2K7,ITCH,MAP2K6,EDN1,CFLAR,MAP3K14,CREB1,PIK3R3,TAB1,MAPK13,TAB2,RIPK1,BIRC2,ICAM1,FOS,MLKL,TRAF3,CASP10,CEBPB,AKT3,TAB3,MAP3K8,DNM1L,MAP3K5,PIK3R1,PIK3R2,CREB3L1,IL1B,MAP2K3,PIK3CB,DAB2IP,TRAF1,BAG4 ko00270 |Cysteine and methionine metabolism |0.000566527683044539|-7.47598461188603|44 |31 |0.0096064456151224 |3227 |7161 |MAT2B,DNMT3B,ADI1,AHCYL2,AMD1,GCLM,MTAP,ENOPH1,BCAT1,MAT2A,GOT1,SDSL,MTR,AGXT2,AHCY,LDHA,TST,TAT,MDH1,LDHAL6B,DNMT1,AHCYL1,DNMT3A,MDH2,SMS,MAT1A,GSS,GCLC,BCAT2,CTH,GOT2 hsa00270 |Cysteine and methionine metabolism |0.000566527683044539|-7.47598461188603|44 |31 |0.0096064456151224 |3227 |7161 |CTH,GOT2,MDH1,DNMT1,LDHAL6B,DNMT3A,SMS,MDH2,AHCYL1,BCAT2,MAT1A,GSS,GCLC,BCAT1,ENOPH1,SDSL,GOT1,MAT2A,AHCY,LDHA,AGXT2,MTR,TST,TAT,MAT2B,DNMT3B,AHCYL2,ADI1,AMD1,GCLM,MTAP hsa05131 |Shigellosis |0.00069918152458724 |-7.26560015761731|64 |42 |0.0130151843817787 |3227 |7161 |NFKB1,NFKBIB,ARPC1B,PFN1,NFKBIA,ABL1,ARPC5,ARPC1A,ARPC2,CRK,NOD2,HCLS1,ATG5,DIAPH1,RHOG,CDC42,ROCK1,MAPK13,SRC,VCL,CXCL8,CTTN,WASL,WASF1,ITGB1,MAPK14,FBXW11,ROCK2,CRKL,U2AF1L4,ELMO1,IKBKG,ACTG1,NOD1,ARPC5L,ACTB,WASF2,DOCK1,RIPK2,PFN2,BTRC,MAPK1 hsa04390 |Hippo signaling pathway |0.000906840936477337|-7.00554349646219|154 |89 |0.027579795475674 |3227 |7161 |TGFBR2,PPP2R1B,TCF7,DLG2,SAV1,AXIN2,SCRIB,PPP1CC,FGF1,FRMD6,FZD9,FZD4,STK3,CCND1,AREG,ITGB2,NKD1,TCF7L2,CTNNB1,WNT3,SMAD3,CDH1,TEAD1,AFP,YWHAZ,BIRC2,YWHAQ,FBXW11,PRKCI,CRB1,TGFB3,BMPR2,CTNNA1,GLI2,ACTB,ID2,TEAD4,BTRC,YWHAB,BMP8A,PARD6G,FZD7,WNT7B,PPP2R2C,DLG1,AXIN1,SMAD4,LATS2,FZD5,PPP2R2D,MPP5,GDF7,WWTR1,LLGL2,SERPINE1,SNAI2,WWC1,BMP6,ID1,SMAD7,WNT10B,PPP1CB,BBC3,PPP2R2A,FZD2,YAP1,CRB2,BMPR1A,RASSF6,PATJ,PPP2CA,PRKCZ,GSK3B,RASSF1,ACTG1,CCND3,WNT11,CCN2,YWHAG,FRMD1,CSNK1E,WNT5A,SMAD1,TP73,PARD6B,CTNNA3,PARD3,BMP4,LIMD1 ko04390 |Hippo signaling pathway |0.000906840936477337|-7.00554349646219|154 |89 |0.027579795475674 |3227 |7161 |RASSF6,CRB2,BMPR1A,PATJ,YAP1,PPP2CA,PRKCZ,GSK3B,ACTG1,WNT11,CCND3,RASSF1,YWHAG,CCN2,TP73,WNT5A,FRMD1,CSNK1E,SMAD1,CTNNA3,PARD6B,BMP4,LIMD1,PARD3,FZD7,DLG1,AXIN1,WNT7B,PPP2R2C,FZD5,SMAD4,PPP2R2D,LATS2,MPP5,WWTR1,LLGL2,GDF7,WWC1,SNAI2,SERPINE1,BMP6,SMAD7,ID1,PPP1CB,WNT10B,PPP2R2A,FZD2,BBC3,PRKCI,YWHAQ,FBXW11,CRB1,TGFB3,BMPR2,CTNNA1,GLI2,ACTB,BTRC,ID2,TEAD4,PARD6G,BMP8A,YWHAB,DLG2,SAV1,TGFBR2,PPP2R1B,TCF7,PPP1CC,FGF1,FZD4,FZD9,STK3,FRMD6,AXIN2,SCRIB,CCND1,AREG,ITGB2,TCF7L2,NKD1,SMAD3,CTNNB1,WNT3,AFP,BIRC2,YWHAZ,CDH1,TEAD1 hsa04012 |ErbB signaling pathway |0.000940012004556836|-6.96961791197663|85 |53 |0.0164239231484351 |3227 |7161 |SOS1,CRKL,AKT3,TGFA,NCK2,EIF4EBP1,ERBB2,KRAS,PIK3R1,PIK3R2,GSK3B,JUN,MAP2K1,NRG4,ERBB3,RAF1,PAK4,PAK2,CAMK2G,SHC3,PIK3CB,CBLB,MAPK1,STAT5B,GRB2,PTK2,ABL1,STAT5A,NRAS,BRAF,MAP2K7,CAMK2D,AREG,EGF,HBEGF,CRK,PRKCA,RPS6KB2,CAMK2A,SHC1,PAK1,CDKN1A,ABL2,NRG1,MTOR,CAMK2B,SRC,PIK3R3,PLCG2,PAK3,BTC,NCK1,SHC4 ko04012 |ErbB signaling pathway |0.000940012004556836|-6.96961791197663|85 |53 |0.0164239231484351 |3227 |7161 |ERBB3,NRG4,RAF1,PAK4,CAMK2G,PAK2,SHC3,PIK3CB,CBLB,MAPK1,SOS1,CRKL,AKT3,TGFA,NCK2,EIF4EBP1,KRAS,ERBB2,GSK3B,PIK3R1,PIK3R2,JUN,MAP2K1,EGF,HBEGF,CRK,RPS6KB2,PRKCA,SHC1,CAMK2A,CDKN1A,ABL2,PAK1,NRG1,CAMK2B,SRC,MTOR,PIK3R3,PLCG2,NCK1,BTC,PAK3,SHC4,STAT5B,GRB2,PTK2,ABL1,STAT5A,NRAS,BRAF,CAMK2D,MAP2K7,AREG ko04520 |Adherens junction |0.00095107672811501 |-6.95791581716451|72 |46 |0.014254725751472 |3227 |7161 |SMAD4,PTPRJ,EP300,TGFBR2,CSNK2B,TCF7,FGFR1,AFDN,PTPRM,SMAD3,RHOA,SRC,VCL,CTNNB1,SNAI1,IQGAP1,CDH1,INSR,SNAI2,CSNK2A2,TCF7L2,FARP2,CDC42,PTPRF,ACP1,ACTG1,ACTN1,ERBB2,WASL,ACTN4,WASF1,NECTIN4,SORBS1,CREBBP,NLK,PTPN1,LMO7,CTNNA3,MAPK1,CSNK2A1,YES1,PARD3,CTNNA1,FYN,ACTB,WASF2 hsa04520 |Adherens junction |0.00095107672811501 |-6.95791581716451|72 |46 |0.014254725751472 |3227 |7161 |YES1,PARD3,PTPN1,LMO7,CTNNA3,MAPK1,CSNK2A1,WASF2,ACTB,CTNNA1,FYN,ACTN1,ACP1,ACTG1,PTPRF,ERBB2,CREBBP,SORBS1,NLK,ACTN4,WASL,WASF1,NECTIN4,CDH1,IQGAP1,SMAD3,SRC,RHOA,CTNNB1,VCL,SNAI1,TCF7L2,CSNK2A2,FARP2,CDC42,INSR,SNAI2,SMAD4,FGFR1,PTPRM,AFDN,PTPRJ,EP300,TGFBR2,TCF7,CSNK2B ko05215 |Prostate cancer |0.000987079542391041|-6.92075993171615|87 |54 |0.0167338084908584 |3227 |7161 |MAP2K1,PIK3R1,GSK3B,PIK3R2,KRAS,ERBB2,CREB3L1,IKBKG,PDPK1,TGFA,HSP90AB1,CREB3,AKT3,CREBBP,SOS1,E2F2,MAPK1,ATF4,PIK3CB,BCL2,PDGFRB,RAF1,CREB3L4,IGF1,CCND1,SRD5A2,CREB3L3,TCF7,EP300,NFKB1,BRAF,NFKBIA,NRAS,CREB3L2,CREB5,GSTP1,PDGFA,GRB2,FGFR1,CTNNB1,HSP90AA1,PIK3R3,CREB1,PDGFC,MTOR,CDKN1A,MDM2,FGFR2,CASP9,E2F3,PDGFRA,EGF,TCF7L2,CCNE1 hsa05215 |Prostate cancer |0.000987079542391041|-6.92075993171615|87 |54 |0.0167338084908584 |3227 |7161 |HSP90AB1,TGFA,CREB3,PDPK1,SOS1,CREBBP,E2F2,AKT3,PIK3R1,GSK3B,PIK3R2,MAP2K1,IKBKG,KRAS,ERBB2,CREB3L1,RAF1,PDGFRB,IGF1,CREB3L4,PIK3CB,MAPK1,ATF4,BCL2,EP300,NFKB1,BRAF,TCF7,GRB2,PDGFA,FGFR1,NFKBIA,NRAS,CREB3L2,CREB5,GSTP1,SRD5A2,CCND1,CREB3L3,FGFR2,CASP9,EGF,TCF7L2,CCNE1,E2F3,PDGFRA,HSP90AA1,PIK3R3,CREB1,PDGFC,MTOR,CTNNB1,MDM2,CDKN1A hsa04360 |Axon guidance |0.00100003496274796 |-6.90772031684536|174 |99 |0.030678648899907 |3227 |7161 |FYN,SEMA6B,SEMA7A,ABLIM2,WNT5A,SSH2,SEMA6A,MAPK1,TRPC3,RYK,NTN4,ABLIM1,PARD6B,PAK2,PARD3,SEMA3G,NRP1,ROBO1,SEMA4D,ITGB1,EFNA1,ROCK2,GNAI3,GNAI2,PRKCZ,GSK3B,PPP3CA,PTPN11,LRRC4C,NCK2,SEMA4B,NTNG2,DPYSL2,CDC42,RGS3,PLCG2,RHOD,SEMA3B,SEMA6D,NCK1,CAMK2B,SRC,PTCH1,ROCK1,PAK1,CAMK2A,PLXNB1,EPHA2,ARHGEF12,SEMA5B,UNC5A,NRAS,CAMK2D,GNAI1,GDF7,SEMA3D,LIMK2,RAF1,EPHA5,BMPR2,PLXNA2,EFNA5,ROBO2,NGEF,SHH,DCC,PIK3CB,CFL2,CXCR4,CAMK2G,PARD6G,PDK1,PAK4,ABLIM3,NTN1,SEMA4C,UNC5D,NFATC3,SSH3,SEMA3C,PIK3R2,PIK3R1,EPHB4,KRAS,PRKCA,NTN3,SEMA4F,SRGAP1,TRPC1,ENAH,PAK3,PLXNC1,NFATC2,RHOA,PIK3R3,EFNB1,PTK2,ABL1,RND1 ko04360 |Axon guidance |0.00100003496274796 |-6.90772031684536|174 |99 |0.030678648899907 |3227 |7161 |CXCR4,CAMK2G,PARD6G,PDK1,PAK4,DCC,EFNA5,SHH,NGEF,ROBO2,PIK3CB,CFL2,PLXNA2,LIMK2,SEMA3D,RAF1,BMPR2,EPHA5,KRAS,PIK3R2,EPHB4,PIK3R1,UNC5D,NFATC3,SSH3,SEMA3C,NTN1,SEMA4C,ABLIM3,EFNB1,ENAH,PAK3,PLXNC1,RHOA,NFATC2,PIK3R3,SEMA4F,SRGAP1,TRPC1,PRKCA,NTN3,RND1,PTK2,ABL1,PARD3,PAK2,ROBO1,NRP1,SEMA3G,MAPK1,TRPC3,RYK,NTN4,PARD6B,ABLIM1,ABLIM2,WNT5A,SSH2,SEMA6A,FYN,SEMA6B,SEMA7A,PTPN11,LRRC4C,PPP3CA,NCK2,GNAI3,GNAI2,PRKCZ,GSK3B,EFNA1,ROCK2,SEMA4D,ITGB1,PAK1,CAMK2A,PLXNB1,PLCG2,SEMA3B,NCK1,RHOD,SEMA6D,SRC,CAMK2B,ROCK1,PTCH1,NTNG2,DPYSL2,CDC42,RGS3,SEMA4B,GDF7,CAMK2D,GNAI1,SEMA5B,UNC5A,NRAS,EPHA2,ARHGEF12 ko04918 |Thyroid hormone synthesis |0.00101465512885673 |-6.89320649875022|74 |47 |0.0145646110938953 |3227 |7161 |GNAS,GPX2,CREB3L3,ATP1B3,LRP2,ATP1B1,GPX3,PRKACA,CREB5,CREB3L2,HSPA5,ADCY4,PLCB4,IYD,ADCY7,GPX7,CREB1,ASGR1,ALB,ITPR3,PLCB1,PRKCA,ADCY3,ADCY8,CANX,FXYD2,CREB3L1,DUOX2,PDIA4,GPX8,ADCY9,ITPR2,ASGR2,GSR,CREB3,SLC5A5,ADCY1,ITPR1,GPX1,ATF4,ATP1A2,ATP1A1,CREB3L4,SERPINA7,GPX5,GPX6,PAX8 hsa04918 |Thyroid hormone synthesis |0.00101465512885673 |-6.89320649875022|74 |47 |0.0145646110938953 |3227 |7161 |ITPR1,ADCY1,GPX1,ATP1A2,ATF4,CREB3L4,ATP1A1,GPX6,PAX8,GPX5,SERPINA7,FXYD2,CANX,ADCY3,ADCY8,CREB3L1,PDIA4,DUOX2,ADCY9,GPX8,ITPR2,ASGR2,GSR,CREB3,SLC5A5,ADCY4,PLCB4,CREB1,GPX7,IYD,ADCY7,ASGR1,ITPR3,ALB,PLCB1,PRKCA,GNAS,CREB3L3,GPX2,LRP2,ATP1B1,ATP1B3,GPX3,PRKACA,CREB3L2,CREB5,HSPA5 ko04920 |Adipocytokine signaling pathway |0.00129102400408598 |-6.65231957388539|69 |44 |0.0136349550666253 |3227 |7161 |ACSL4,ACSL1,G6PC,TRAF2,RXRA,PCK1,SLC2A1,CD36,SLC2A4,PPARGC1A,ADIPOR2,SOCS3,ACSBG1,ACSL3,IKBKG,STAT3,PRKAA1,ADIPOR1,PTPN11,G6PC3,LEP,AKT3,PPARA,MTOR,CPT1A,PRKAB2,ACACB,PRKAG2,RXRB,PCK2,IRS1,ACSL5,JAK2,ACSL6,PRKAB1,LEPR,PRKAG1,G6PC2,TNFRSF1A,NFKB1,NFKBIB,ACSBG2,POMC,NFKBIA hsa04920 |Adipocytokine signaling pathway |0.00129102400408598 |-6.65231957388539|69 |44 |0.0136349550666253 |3227 |7161 |PPARGC1A,ADIPOR2,ACSBG1,SOCS3,ADIPOR1,IKBKG,ACSL3,PRKAA1,STAT3,PTPN11,G6PC3,LEP,PPARA,AKT3,ACSL4,ACSL1,G6PC,TRAF2,RXRA,PCK1,CD36,SLC2A1,SLC2A4,PRKAG1,G6PC2,LEPR,TNFRSF1A,ACSBG2,NFKB1,NFKBIB,POMC,NFKBIA,PRKAB2,CPT1A,MTOR,ACACB,PRKAG2,PCK2,RXRB,ACSL5,IRS1,ACSL6,PRKAB1,JAK2 ko05205 |Proteoglycans in cancer |0.00135094391087437 |-6.60695173761324|203 |113 |0.0350170436938333 |3227 |7161 |FAS,FN1,ITGB1,MAPK14,ANK2,SOS1,ROCK2,IHH,CAV1,MMP9,ANK3,MMP2,GPC3,MAP2K1,ITPR2,WNT11,HIF1A,ACTG1,COL21A1,PTPN11,CTSL,IGF1,ERBB3,WNT5A,ITGB3,PPP1R12B,CBLB,MAPK1,ITPR1,FZD7,ARHGEF12,IGF2,RDX,MRAS,NRAS,ESR1,WNT7B,CAMK2D,TWIST2,FZD5,ITGA2,MIR21,PXN,SLC9A1,HCLS1,CDC42,HBEGF,CAMK2B,SRC,SDC1,ROCK1,WNT10B,PPP1CB,PTCH1,PLCG2,HSPG2,TFAP4,FZD2,CAMK2A,SDC4,PAK1,VAV2,IQGAP1,SDC2,PDPK1,FASLG,AKT3,PIK3R2,PIK3R1,STAT3,KRAS,ERBB2,RAF1,RRAS2,VEGFA,FRS2,ACTB,VTN,FLNB,PIK3CB,GPC1,ITGB5,PDCD4,SHH,CAMK2G,EIF4B,BRAF,ANK1,FZD4,FGFR1,FZD9,PPP1CC,PRKACA,GRB2,PTK2,TIMP3,CCND1,DDX5,RPS6KB2,PRKCA,ARHGEF1,ITPR3,MAPK13,RHOA,MTOR,PIK3R3,WNT3,CTNNB1,MDM2,CTTN,FGF2,THBS1,CDKN1A hsa05205 |Proteoglycans in cancer |0.00135094391087437 |-6.60695173761324|203 |113 |0.0350170436938333 |3227 |7161 |IHH,ROCK2,SOS1,CAV1,MMP9,FAS,MAPK14,ANK2,ITGB1,FN1,ACTG1,HIF1A,WNT11,PTPN11,COL21A1,MMP2,ANK3,ITPR2,GPC3,MAP2K1,ERBB3,IGF1,ITGB3,WNT5A,CTSL,ITPR1,MAPK1,CBLB,PPP1R12B,MRAS,RDX,NRAS,ESR1,WNT7B,FZD7,IGF2,ARHGEF12,MIR21,PXN,FZD5,TWIST2,CAMK2D,ITGA2,CDC42,HBEGF,HCLS1,SLC9A1,SDC4,CAMK2A,FZD2,VAV2,IQGAP1,PAK1,ROCK1,PTCH1,PPP1CB,WNT10B,SRC,CAMK2B,SDC1,HSPG2,TFAP4,PLCG2,FASLG,AKT3,SDC2,PDPK1,STAT3,KRAS,ERBB2,PIK3R1,PIK3R2,FRS2,ACTB,FLNB,VTN,RAF1,VEGFA,RRAS2,CAMK2G,EIF4B,ITGB5,PIK3CB,GPC1,SHH,PDCD4,PRKACA,PPP1CC,GRB2,FZD4,ANK1,FGFR1,FZD9,PTK2,BRAF,TIMP3,DDX5,CCND1,ITPR3,ARHGEF1,RPS6KB2,PRKCA,FGF2,THBS1,CTTN,MDM2,CDKN1A,PIK3R3,MAPK13,RHOA,MTOR,CTNNB1,WNT3 hsa04371 |Apelin signaling pathway |0.0014271475131195 |-6.55207757293621|138 |80 |0.0247908273938643 |3227 |7161 |GNG10,NRAS,PLIN1,MRAS,SMAD4,GNAI1,CAMK4,CALM1,SERPINE1,SLC9A1,MYLK,APLN,SPP1,MEF2A,GNB5,PLCB4,CALM2,PIK3CG,SPHK1,NOS1,PIK3C3,PDE3B,GNAI3,MAP2K1,GNAI2,ITPR2,NRF1,PRKAA1,MYLK3,CCN2,MAPK1,KLF2,ADCY1,ITPR1,PRKCE,NOTCH3,MYL4,GNGT2,JAG1,CALML5,PIK3R5,PRKACA,CCND1,PRKAG1,RPS6KB2,SLC8A3,GNG7,TFAM,PLCB1,PRKAB1,ITPR3,PRKAG2,MTOR,ADCY7,GNB4,SMAD3,PRKAB2,GABARAPL2,CDH1,ADCY4,AKT3,ADCY10,LIPE,SPHK2,GNG4,PPARGC1A,ADCY9,KRAS,ADCY8,ADCY3,RRAS2,RAF1,HDAC5,AGTR1,MYLK4,EGR1,BECN2,MEF2B,HDAC4,GABARAPL1 hsa04213 |Longevity regulating pathway - multiple species |0.00152819581178286 |-6.48366744737565|62 |40 |0.0123954136969321 |3227 |7161 |EIF4EBP2,FOXO3,PRKAB1,HDAC2,SOD1,INSR,AKT1S1,ATG5,RPS6KB2,ADCY4,IRS1,PRKAB2,PIK3R3,HSPA6,MTOR,ADCY7,PRKAG2,FOXA2,PRKACA,NRAS,SOD2,PRKAG1,CAT,IGF1,HSPA1B,HSPA8,ADCY1,PIK3CB,AKT3,RPTOR,PRKAA1,ADCY8,HSPA1A,ADCY3,KRAS,ADCY9,SIRT1,PIK3R2,PIK3R1,CLPB ko04213 |Longevity regulating pathway - multiple species |0.00152819581178286 |-6.48366744737565|62 |40 |0.0123954136969321 |3227 |7161 |PIK3CB,HSPA8,ADCY1,HSPA1B,IGF1,CLPB,PIK3R2,PIK3R1,SIRT1,ADCY9,KRAS,ADCY3,ADCY8,HSPA1A,PRKAA1,RPTOR,AKT3,PRKAG2,HSPA6,MTOR,ADCY7,PRKAB2,PIK3R3,IRS1,ADCY4,RPS6KB2,ATG5,AKT1S1,INSR,SOD1,HDAC2,PRKAB1,FOXO3,EIF4EBP2,CAT,PRKAG1,SOD2,NRAS,PRKACA,FOXA2 hsa00100 |Steroid biosynthesis |0.00153900645495335 |-6.4766182298825 |20 |16 |0.00495816547877285 |3227 |7161 |CYP51A1,CYP2R1,MSMO1,HSD17B7,LIPA,TM7SF2,CYP27B1,DHCR24,SOAT2,CYP24A1,FAXDC2,NSDHL,SOAT1,SC5D,FDFT1,DHCR7 ko00100 |Steroid biosynthesis |0.00153900645495335 |-6.4766182298825 |20 |16 |0.00495816547877285 |3227 |7161 |LIPA,CYP27B1,TM7SF2,CYP2R1,CYP51A1,HSD17B7,MSMO1,FDFT1,DHCR7,SOAT2,CYP24A1,FAXDC2,DHCR24,NSDHL,SC5D,SOAT1 ko00071 |Fatty acid degradation |0.00161860666898777 |-6.42618958069136|44 |30 |0.0092965602726991 |3227 |7161 |ALDH2,ACADVL,HADHB,CPT2,ECI2,ACSL6,ACOX3,ECI1,HADH,ACADS,ACSL4,ACSL1,CPT1A,ACSL5,ADH6,ACOX1,ADH7,ALDH7A1,ACADL,ACSBG2,HADHA,ACAA1,ALDH1B1,ACSBG1,ALDH3A2,ADH5,ACADSB,ACAT2,ADH4,ACSL3 hsa00071 |Fatty acid degradation |0.00161860666898777 |-6.42618958069136|44 |30 |0.0092965602726991 |3227 |7161 |ACSBG2,HADHA,ACADL,ALDH7A1,ALDH1B1,ACAA1,ALDH3A2,ACSBG1,ADH4,ACSL3,ACAT2,ADH5,ACADSB,CPT2,HADHB,ALDH2,ACADVL,ACOX3,ACSL6,ECI2,CPT1A,ACSL4,ACSL1,ACADS,ECI1,HADH,ADH7,ACOX1,ACSL5,ADH6 ko00450 |Selenocompound metabolism |0.00187724938495576 |-6.27794766661477|17 |14 |0.00433839479392625 |3227 |7161 |PAPSS2,SEPHS2,KYAT3,MTR,SCLY,PSTK,CTH,PAPSS1,TXNRD1,SEPHS1,MARS,MARS2,KYAT1,TXNRD2 hsa00450 |Selenocompound metabolism |0.00187724938495576 |-6.27794766661477|17 |14 |0.00433839479392625 |3227 |7161 |SEPHS1,TXNRD1,KYAT1,TXNRD2,MARS2,MARS,MTR,SCLY,KYAT3,SEPHS2,PAPSS2,PAPSS1,CTH,PSTK hsa03320 |PPAR signaling pathway |0.00208197127742116 |-6.17444010455159|72 |45 |0.0139448404090487 |3227 |7161 |ACADL,PDPK1,CYP27A1,SLC27A5,PPARA,ACAA1,SLC27A4,SORBS1,ACSBG1,GK,UBC,ACSL3,APOA1,CD36,PCK1,RXRA,PPARG,PPARD,FABP1,SLC27A2,SLC27A1,CYP8B1,ACSL1,APOA5,ACSL4,DBI,NR1H3,ACSBG2,ACOX2,PLIN1,SCP2,PLIN4,APOC3,PLIN2,APOA2,CPT2,ACSL6,HMGCS2,ACOX3,CPT1A,ACSL5,PLTP,PCK2,ACOX1,RXRB ko03320 |PPAR signaling pathway |0.00208197127742116 |-6.17444010455159|72 |45 |0.0139448404090487 |3227 |7161 |RXRB,ACOX1,PCK2,PLTP,ACSL5,CPT1A,ACOX3,HMGCS2,ACSL6,CPT2,APOA2,PLIN2,PLIN4,SCP2,APOC3,PLIN1,ACOX2,ACSBG2,NR1H3,DBI,ACSL4,APOA5,SLC27A1,ACSL1,CYP8B1,SLC27A2,FABP1,PPARD,PPARG,PCK1,RXRA,CD36,APOA1,ACSL3,UBC,GK,ACSBG1,SORBS1,SLC27A4,ACAA1,SLC27A5,PPARA,CYP27A1,ACADL,PDPK1 ko00561 |Glycerolipid metabolism |0.00208286331084826 |-6.17401174014871|59 |38 |0.0117756430120855 |3227 |7161 |LIPG,GPAT4,DGKQ,MOGAT1,AKR1B1,DGKI,GLYCTK,GK,DGKZ,AGPAT3,PNPLA2,DGKK,LCLAT1,AGPAT1,DGKD,DGKE,MOGAT2,MBOAT1,GPAT2,LPIN2,PNPLA3,PLPP1,LPIN3,ALDH2,GPAT3,DGAT1,ALDH3A2,DGKA,GPAM,PLPP3,AGPAT4,ALDH7A1,AKR1A1,LIPC,LPIN1,MGLL,ALDH1B1,AGPAT2 hsa00561 |Glycerolipid metabolism |0.00208286331084826 |-6.17401174014871|59 |38 |0.0117756430120855 |3227 |7161 |AGPAT4,PLPP3,GPAM,DGKA,ALDH3A2,AGPAT2,ALDH1B1,AKR1A1,MGLL,LPIN1,LIPC,ALDH7A1,PLPP1,LPIN2,PNPLA3,GPAT2,DGAT1,LPIN3,ALDH2,GPAT3,LCLAT1,DGKK,PNPLA2,AGPAT3,GK,DGKZ,MBOAT1,MOGAT2,DGKE,DGKD,AGPAT1,MOGAT1,DGKQ,GPAT4,LIPG,GLYCTK,DGKI,AKR1B1 ko01230 |Biosynthesis of amino acids |0.00218818927033894 |-6.12468089435243|74 |46 |0.014254725751472 |3227 |7161 |CS,AADAT,PSPH,ASL,MAT2B,TALDO1,PKM,PAH,GPT,PGK2,ARG1,BCAT1,PYCR1,SDSL,RPEL1,ACO1,PFKL,PFKP,PHGDH,SHMT2,PYCR2,IDH2,IDH1,MTR,TAT,RPIA,ALDH7A1,MAT2A,RPE,PGK1,GOT1,GPT2,ALDH18A1,CPS1,MAT1A,ALDOA,BCAT2,OTC,ALDOB,GAPDH,ACO2,GOT2,IDH3A,PSAT1,CTH,ASS1 hsa01230 |Biosynthesis of amino acids |0.00218818927033894 |-6.12468089435243|74 |46 |0.014254725751472 |3227 |7161 |CTH,IDH3A,PSAT1,GOT2,ASS1,ALDH18A1,GPT2,BCAT2,ALDOA,MAT1A,CPS1,OTC,ACO2,ALDOB,GAPDH,MTR,ALDH7A1,TAT,RPIA,PGK1,RPE,GOT1,MAT2A,PYCR2,IDH2,IDH1,PHGDH,PFKP,SHMT2,RPEL1,PFKL,ACO1,TALDO1,PKM,PYCR1,BCAT1,GPT,PAH,ARG1,PGK2,SDSL,AADAT,CS,PSPH,MAT2B,ASL ko05219 |Bladder cancer |0.00221985118908387 |-6.11031511728889|41 |28 |0.00867678958785249 |3227 |7161 |SRC,CXCL8,MAPK1,MDM2,THBS1,CDH1,CDKN1A,DAPK1,RAF1,TYMP,VEGFA,EGF,E2F3,HBEGF,MMP2,MAP2K1,CCND1,FGFR3,RASSF1,KRAS,ERBB2,BRAF,CDK4,UPK3A,DAPK2,E2F2,MMP9,NRAS hsa05219 |Bladder cancer |0.00221985118908387 |-6.11031511728889|41 |28 |0.00867678958785249 |3227 |7161 |CCND1,MAP2K1,MMP2,ERBB2,KRAS,RASSF1,FGFR3,UPK3A,DAPK2,CDK4,BRAF,NRAS,MMP9,E2F2,MAPK1,CXCL8,SRC,CDH1,CDKN1A,THBS1,MDM2,TYMP,VEGFA,RAF1,DAPK1,HBEGF,E2F3,EGF hsa04722 |Neurotrophin signaling pathway |0.00292243717885148 |-5.8353373605372 |119 |69 |0.0213820886272079 |3227 |7161 |FRS2,RIPK2,RAF1,PSEN1,CAMK2G,SHC3,PIK3CB,FASLG,CRKL,SH2B3,AKT3,PDPK1,SH2B2,KRAS,PIK3R1,PIK3R2,MAP3K5,ARHGDIA,SHC1,NTRK3,RHOA,RAPGEF1,MAPK13,ZNF274,PIK3R3,SHC4,CALML5,GRB2,IRAK2,ABL1,NFKBIA,BRAF,NFKBIB,MAP2K7,RPS6KA1,TP73,MAP3K1,RPS6KA2,BCL2,ATF4,MAPK1,SOS1,SORT1,MAP3K3,MAPK14,PTPN11,GSK3B,JUN,MAP2K1,MAPKAPK2,CDC42,FOXO3,CRK,RPS6KA3,CAMK2A,CALM2,IRS1,NTF3,CAMK2B,PLCG2,IRAK1,NRAS,NFKB1,PRKCD,CALM1,CAMK4,NTRK2,CAMK2D,KIDINS220 ko04722 |Neurotrophin signaling pathway |0.00292243717885148 |-5.8353373605372 |119 |69 |0.0213820886272079 |3227 |7161 |ARHGDIA,SHC1,NTRK3,RAPGEF1,MAPK13,RHOA,ZNF274,PIK3R3,SHC4,CALML5,GRB2,IRAK2,ABL1,NFKBIA,NFKBIB,BRAF,MAP2K7,RPS6KA1,FRS2,RIPK2,RAF1,PSEN1,CAMK2G,SHC3,PIK3CB,FASLG,CRKL,SH2B3,AKT3,PDPK1,SH2B2,KRAS,PIK3R1,PIK3R2,MAP3K5,MAPKAPK2,CDC42,FOXO3,CRK,RPS6KA3,CAMK2A,CALM2,NTF3,IRS1,CAMK2B,PLCG2,IRAK1,NRAS,NFKB1,PRKCD,CALM1,NTRK2,CAMK4,CAMK2D,KIDINS220,TP73,MAP3K1,RPS6KA2,BCL2,ATF4,MAPK1,SOS1,SORT1,MAP3K3,MAPK14,PTPN11,GSK3B,JUN,MAP2K1 hsa04976 |Bile secretion |0.00294955001687136 |-5.82610265691908|71 |44 |0.0136349550666253 |3227 |7161 |ATP1A1,NR1H4,RXRA,SLC2A1,ADCY1,AQP9,SLC51A,ABCG8,LDLR,NCEH1,ATP1A2,ABCC4,SLC51B,SLC27A5,SLC22A7,UGT2B4,SULT2A1,ADCY3,ADCY8,FXYD2,SLC22A8,NR0B2,ADCY9,ABCC2,CYP3A4,SLC9A1,SLC4A5,ADCY4,EPHX1,BAAT,ADCY7,SLCO1B3,ABCG2,PRKACA,ABCG5,SCARB1,AQP4,GNAS,HMGCR,AQP8,ABCB4,ATP1B3,ATP1B1,ABCC3 ko04976 |Bile secretion |0.00294955001687136 |-5.82610265691908|71 |44 |0.0136349550666253 |3227 |7161 |ATP1A1,RXRA,NR1H4,SLC2A1,SLC51A,ADCY1,AQP9,ABCG8,ATP1A2,NCEH1,LDLR,SLC22A7,SLC27A5,ABCC4,SLC51B,SULT2A1,UGT2B4,FXYD2,ADCY3,ADCY8,NR0B2,SLC22A8,ADCY9,ABCC2,CYP3A4,SLC9A1,EPHX1,ADCY4,SLC4A5,BAAT,SLCO1B3,ADCY7,ABCG2,PRKACA,ABCG5,SCARB1,GNAS,AQP4,AQP8,HMGCR,ABCB4,ABCC3,ATP1B1,ATP1B3 hsa04140 |Autophagy - animal |0.00306847855327549 |-5.78657342547827|127 |73 |0.0226216299969011 |3227 |7161 |RHEB,RRAS2,RAF1,AMBRA1,GABARAPL1,ZFYVE1,BECN2,PIK3CB,AKT3,ERN1,DAPK2,PDPK1,KRAS,CTSB,RPTOR,PIK3R1,PIK3R2,CFLAR,RPS6KB2,LAMP1,ATG5,AKT1S1,SH3GLB1,GABARAPL2,NRBF2,RRAGC,MTOR,PIK3R3,ATG10,CTSD,RAB33B,PRKACA,ATG2A,ATG4B,PRAP1,MTMR3,CTSL,LAMP2,BCL2,ITPR1,MAPK1,RRAGB,VAMP8,HMGB1,PPP2CA,ATG14,ATG16L1,MTMR4,PIK3C3,BCL2L1,UVRAG,ATG13,HIF1A,PRKAA1,MAP2K1,ATG4C,DEPTOR,SNAP29,TP53INP2,DAPK1,RAB7A,IRS1,DDIT4,TSC2,VMP1,NRAS,BNIP3,MRAS,PRKCD,MTMR14,EIF2AK3,ATG7,WIPI1 ko04140 |Autophagy - animal |0.00306847855327549 |-5.78657342547827|127 |73 |0.0226216299969011 |3227 |7161 |NRBF2,GABARAPL2,RRAGC,PIK3R3,MTOR,CFLAR,ATG5,LAMP1,RPS6KB2,SH3GLB1,AKT1S1,ATG2A,PRAP1,ATG4B,ATG10,PRKACA,CTSD,RAB33B,GABARAPL1,ZFYVE1,BECN2,PIK3CB,RHEB,RRAS2,AMBRA1,RAF1,KRAS,RPTOR,CTSB,PIK3R2,PIK3R1,AKT3,ERN1,DAPK2,PDPK1,IRS1,DDIT4,VMP1,TSC2,DEPTOR,SNAP29,TP53INP2,RAB7A,DAPK1,EIF2AK3,WIPI1,ATG7,NRAS,BNIP3,MRAS,MTMR14,PRKCD,LAMP2,BCL2,ITPR1,MAPK1,RRAGB,CTSL,MTMR3,BCL2L1,UVRAG,PRKAA1,HIF1A,ATG13,MAP2K1,ATG4C,VAMP8,HMGB1,PPP2CA,ATG16L1,ATG14,MTMR4,PIK3C3 hsa04710 |Circadian rhythm |0.003133247332233 |-5.76568532591065|31 |22 |0.00681747753331267 |3227 |7161 |PER1,BTRC,CREB1,PRKAB2,PER3,NPAS2,PRKAG2,PER2,CSNK1E,PRKAB1,BHLHE40,RORA,CRY1,ARNTL,PRKAG1,PRKAA1,RORC,FBXL3,SKP1,CUL1,FBXW11,NR1D1 ko04710 |Circadian rhythm |0.003133247332233 |-5.76568532591065|31 |22 |0.00681747753331267 |3227 |7161 |PER3,CREB1,PRKAB2,BTRC,NPAS2,PRKAG2,PER1,RORA,BHLHE40,CRY1,ARNTL,PER2,PRKAB1,CSNK1E,PRKAA1,PRKAG1,CUL1,NR1D1,FBXW11,SKP1,RORC,FBXL3 hsa04550 |Signaling pathways regulating pluripotency of stem cells |0.00323253437370307 |-5.73448881359195|139 |79 |0.024480942051441 |3227 |7161 |SMARCAD1,DLX5,PCGF6,AKT3,STAT3,KRAS,ESRRB,PIK3R1,PIK3R2,HAND1,ZIC3,DUSP9,BMPR2,RAF1,ACVR1,MEIS1,PIK3CB,ID2,GRB2,FZD4,FZD9,FGFR1,NODAL,AXIN2,SMAD5,ACVR2A,PCGF3,HESX1,ACVR1B,REST,IL6ST,JAK2,JAK1,SETDB1,JARID2,FGF2,ONECUT1,PIK3R3,SMAD9,SMAD3,MAPK13,CTNNB1,WNT3,PCGF1,BMPR1A,ZFHX3,MAPK14,WNT11,FGFR3,FGFR4,KLF4,GSK3B,HNF1A,PCGF5,MAP2K1,IGF1,KAT6A,WNT5A,SMAD1,BMP4,MAPK1,AXIN1,WNT7B,NRAS,INHBB,FZD7,TCF3,SMAD4,FZD5,INHBC,TBX3,ID4,OTX1,FGFR2,ID1,LIFR,FZD2,WNT10B,INHBE ko04550 |Signaling pathways regulating pluripotency of stem cells |0.00323253437370307 |-5.73448881359195|139 |79 |0.024480942051441 |3227 |7161 |FGFR3,WNT11,MAP2K1,HNF1A,PCGF5,GSK3B,FGFR4,KLF4,PCGF1,MAPK14,ZFHX3,BMPR1A,BMP4,MAPK1,SMAD1,WNT5A,KAT6A,IGF1,TCF3,TBX3,INHBC,SMAD4,FZD5,INHBB,WNT7B,NRAS,AXIN1,FZD7,FZD2,INHBE,WNT10B,ID4,LIFR,ID1,OTX1,FGFR2,ESRRB,KRAS,STAT3,HAND1,ZIC3,PIK3R2,PIK3R1,PCGF6,AKT3,DLX5,SMARCAD1,ACVR1,ID2,PIK3CB,MEIS1,DUSP9,BMPR2,RAF1,PCGF3,ACVR2A,REST,ACVR1B,HESX1,NODAL,AXIN2,FZD9,FZD4,FGFR1,GRB2,SMAD5,ONECUT1,FGF2,WNT3,CTNNB1,MAPK13,SMAD9,PIK3R3,SMAD3,JAK2,IL6ST,JARID2,SETDB1,JAK1 hsa04932 |Non-alcoholic fatty liver disease (NAFLD) |0.00329207038024551 |-5.71623861722042|145 |82 |0.0254105980787109 |3227 |7161 |ADIPOR1,PRKAA1,SOCS3,UQCRHL,GSK3B,JUN,NDUFAB1,UQCRC2,COX5A,SDHB,UQCRC1,IL6R,FAS,MLXIP,TRAF2,ATF4,MLX,CYCS,NDUFA8,NDUFS4,NDUFB11,RXRA,TNFRSF1A,EIF2AK3,CEBPA,NDUFS1,NDUFC1,COX4I2,NR1H3,COX6C,NFKB1,IRS1,CASP8,NDUFA11,CDC42,COX8A,NDUFB9,NDUFV2,INSR,NDUFA12,NDUFB4,NDUFS5,LEP,COX7A2L,PIK3R2,ADIPOR2,PIK3R1,MAP3K5,UQCRFS1,AKT3,PPARA,ERN1,FASLG,UQCRB,IL1A,NDUFS7,COX6B1,UQCR10,XBP1,NDUFA4,BCL2L11,SREBF1,PIK3CB,COX6A1,DDIT3,COX4I1,IL1B,NDUFB7,ITCH,LEPR,PRKAG1,NDUFB6,COX5B,COX7A2,MLXIPL,PRKAG2,CXCL8,PIK3R3,PRKAB2,NDUFB3,PRKAB1,GSK3A ko04072 |Phospholipase D signaling pathway |0.00329207038024551 |-5.71623861722042|145 |82 |0.0254105980787109 |3227 |7161 |PIK3CB,PLA2G4C,RAPGEF4,SHC3,RAF1,DNM2,RRAS2,AGTR1,RHEB,DGKI,ADCY9,PIK3R1,AGPAT3,PIK3R2,SPHK2,DGKZ,AVPR1A,ADCY3,ADCY8,DGKK,KRAS,DGKD,DGKE,AKT3,PIK3R3,RHOA,PDGFC,ADCY7,MTOR,CXCL8,SHC4,ADCY4,LPAR6,SHC1,RALGDS,PRKCA,PTGFR,PLCB1,PDGFRA,AGPAT4,PIP5K1A,DGKA,GRB2,PIK3R5,KIT,MAPK1,ADCY1,DGKQ,FYN,PDGFRB,GAB2,MAP2K1,PTPN11,ARF6,PLD1,SPHK1,AGPAT1,CXCR1,SOS1,KITLG,TSC2,GNA12,PLCG2,RALA,PLPP1,PIK3CG,PLCB4,INSR,PIP5K1B,CYTH1,EGF,PLA2G4E,CYTH3,GNAS,PLPP3,ARF1,PTK2B,MRAS,AGPAT2,RALB,PDGFA,NRAS hsa04072 |Phospholipase D signaling pathway |0.00329207038024551 |-5.71623861722042|145 |82 |0.0254105980787109 |3227 |7161 |PIK3R2,AGPAT3,PIK3R1,ADCY9,SPHK2,DGKZ,ADCY8,AVPR1A,ADCY3,DGKK,KRAS,DGKD,DGKE,AKT3,PIK3CB,RAPGEF4,SHC3,PLA2G4C,RAF1,RRAS2,DNM2,RHEB,DGKI,AGTR1,AGPAT4,PIP5K1A,DGKA,KIT,GRB2,PIK3R5,PDGFC,RHOA,MTOR,ADCY7,PIK3R3,CXCL8,SHC4,SHC1,ADCY4,LPAR6,PRKCA,RALGDS,PTGFR,PLCB1,PDGFRA,MAP2K1,PTPN11,PLD1,ARF6,AGPAT1,SPHK1,SOS1,CXCR1,KITLG,MAPK1,ADCY1,DGKQ,PDGFRB,FYN,GAB2,PLA2G4E,CYTH3,GNAS,ARF1,PLPP3,PTK2B,AGPAT2,PDGFA,MRAS,RALB,NRAS,TSC2,PLCG2,GNA12,PLPP1,RALA,PLCB4,PIK3CG,INSR,PIP5K1B,CYTH1,EGF ko04932 |Non-alcoholic fatty liver disease (NAFLD) |0.00329207038024551 |-5.71623861722042|145 |82 |0.0254105980787109 |3227 |7161 |FAS,IL6R,UQCRC1,COX5A,SDHB,NDUFAB1,UQCRC2,GSK3B,JUN,UQCRHL,SOCS3,ADIPOR1,PRKAA1,RXRA,NDUFB11,NDUFA8,NDUFS4,MLX,CYCS,ATF4,MLXIP,TRAF2,NFKB1,NR1H3,COX6C,COX4I2,NDUFS1,NDUFC1,TNFRSF1A,CEBPA,EIF2AK3,NDUFV2,INSR,NDUFA12,NDUFB9,COX8A,NDUFA11,CDC42,CASP8,IRS1,COX6B1,NDUFS7,UQCRB,ERN1,FASLG,IL1A,AKT3,PPARA,PIK3R1,UQCRFS1,ADIPOR2,PIK3R2,MAP3K5,LEP,NDUFS5,NDUFB4,COX7A2L,IL1B,DDIT3,COX4I1,COX6A1,PIK3CB,SREBF1,NDUFA4,XBP1,BCL2L11,UQCR10,COX7A2,NDUFB6,COX5B,LEPR,PRKAG1,ITCH,NDUFB7,NDUFB3,PRKAB1,GSK3A,PRKAB2,PIK3R3,PRKAG2,CXCL8,MLXIPL ko01521 |EGFR tyrosine kinase inhibitor resistance |0.00346353348430517 |-5.66546597278303|79 |48 |0.0148744964363186 |3227 |7161 |NRG1,SHC1,FGF2,PLCG2,EIF4E2,SHC4,MTOR,PDGFC,SRC,PIK3R3,PDGFRA,JAK2,FOXO3,EGF,PRKCA,RPS6KB2,JAK1,FGFR2,NRAS,GRB2,PDGFA,NF1,BRAF,SHC3,BCL2,BCL2L11,MAPK1,PIK3CB,IGF1,ERBB3,VEGFA,PDGFRB,RAF1,FGFR3,KRAS,ERBB2,BCL2L1,STAT3,EIF4EBP1,MAP2K1,PIK3R2,GSK3B,PIK3R1,AKT3,SOS1,EIF4E,IL6R,TGFA hsa01521 |EGFR tyrosine kinase inhibitor resistance |0.00346353348430517 |-5.66546597278303|79 |48 |0.0148744964363186 |3227 |7161 |AKT3,SOS1,EIF4E,IL6R,TGFA,BCL2L1,KRAS,ERBB2,FGFR3,EIF4EBP1,STAT3,MAP2K1,PIK3R1,GSK3B,PIK3R2,ERBB3,IGF1,VEGFA,PDGFRB,RAF1,SHC3,BCL2,BCL2L11,MAPK1,PIK3CB,NRAS,PDGFA,GRB2,NF1,BRAF,FOXO3,JAK2,PDGFRA,EGF,RPS6KB2,PRKCA,JAK1,FGFR2,NRG1,FGF2,SHC1,SHC4,PLCG2,EIF4E2,PIK3R3,MTOR,SRC,PDGFC ko05418 |Fluid shear stress and atherosclerosis |0.0042060715072478 |-5.47122620059845|142 |80 |0.0247908273938643 |3227 |7161 |TXN2,SUMO2,HMOX1,MGST2,MGST3,MAP3K5,PIK3R2,PIK3R1,IL1R2,HSP90AB1,SDC2,FOS,AKT3,IL1A,GPC1,PIK3CB,ACVR1,DUSP1,VEGFA,IL1B,BMPR2,ACTB,MAP2K7,ACVR2A,SUMO3,IL1R1,MAP2K6,GSTO2,NFE2L2,KEAP1,GSTP1,PTK2,CALML5,CTNNB1,GSTO1,PIK3R3,MAPK13,RHOA,ICAM1,NOX3,TRPV4,MGST1,EDN1,JUN,MMP2,NOX1,PRKCZ,CYBA,PRKAA1,ACTG1,IKBKG,SQSTM1,MAPK14,BMPR1A,CAV1,MMP9,PECAM1,KLF2,BCL2,BMP4,CTSL,ITGB3,TNFRSF1A,CALM1,ARHGEF2,NFKB1,PDGFA,MEF2A,CDH5,HSP90AA1,SRC,SDC1,NCF2,CALM2,GSTA1,SDC4,SELE,TXN,ASS1,GSTA3 hsa05418 |Fluid shear stress and atherosclerosis |0.0042060715072478 |-5.47122620059845|142 |80 |0.0247908273938643 |3227 |7161 |PTK2,GSTP1,CALML5,KEAP1,NFE2L2,IL1R1,MAP2K6,SUMO3,ACVR2A,GSTO2,MAP2K7,EDN1,MGST1,NOX3,ICAM1,TRPV4,CTNNB1,RHOA,MAPK13,GSTO1,PIK3R3,AKT3,IL1A,FOS,HSP90AB1,SDC2,IL1R2,SUMO2,TXN2,PIK3R1,PIK3R2,MAP3K5,MGST3,MGST2,HMOX1,ACTB,VEGFA,DUSP1,BMPR2,IL1B,ACVR1,GPC1,PIK3CB,PDGFA,NFKB1,ARHGEF2,TNFRSF1A,CALM1,ASS1,GSTA3,TXN,CALM2,GSTA1,SDC4,SELE,CDH5,MEF2A,NCF2,SRC,SDC1,HSP90AA1,MMP9,CAV1,PECAM1,MAPK14,BMPR1A,SQSTM1,ACTG1,IKBKG,PRKAA1,PRKCZ,CYBA,MMP2,JUN,NOX1,ITGB3,CTSL,KLF2,BCL2,BMP4 ko04010 |MAPK signaling pathway |0.00424726476423565 |-5.46148008812119|255 |136 |0.0421444065695693 |3227 |7161 |FGF20,TRAF2,MAP3K1,JUN,CACNG4,PTPRR,IKBKG,RASGRP2,PPP3CA,FGFR3,CACNA1A,MAPK14,MAP3K3,SOS1,DUSP10,DUSP6,GNA12,DUSP7,NTF3,CRK,RASGRF1,CDC42,MAP4K3,TNFRSF1A,RASGRP4,MRAS,PPP5C,RAF1,DUSP1,DDIT3,CACNA1D,DUSP9,MAP3K5,SRF,TGFB3,IL1R2,FOS,IL1A,CRKL,FASLG,NFATC3,NLK,DUSP5,MAP3K8,MAPK13,TAB1,TAB2,CACNA2D4,FGF2,GADD45B,PRKCA,PPM1B,MAP4K2,PDGFRA,NR4A1,RASGRP3,IL1R1,MAP2K6,FGF21,BRAF,TGFBR2,GRB2,PRKACA,FGFR1,TAOK1,MAPK1,ATF4,HSPB1,CACNB3,CACNA1E,PAK2,HSPA1B,CDC25B,MAP3K4,FGF14,RPS6KA2,NFKB2,FGF19,PDGFRB,FGF9,CACNG1,FGFR4,MAP3K13,DUSP16,MAP2K1,HSPA1A,FAS,ELK4,STK4,PTPN5,TAOK3,MKNK2,GADD45A,ARRB1,PAK1,FGFR2,RPS6KA3,RASGRF2,EGF,FGF10,MAPKAPK2,PLA2G4E,FGF3,NTRK2,NFKB1,NF1,PDGFA,NRAS,MAPK8IP3,HSPA8,PLA2G4C,IL1B,MAP4K4,RASA2,RRAS2,CD14,MAP2K3,FLNB,KRAS,CACNB4,GADD45G,CACNG6,MAPKAPK3,CACNA2D3,AKT3,DUSP3,MAP3K14,MAP3K20,HSPA6,ECSIT,MAP3K12,RPS6KA1,MAP2K7,RAPGEF2,FGF1,STK3 hsa04010 |MAPK signaling pathway |0.00424726476423565 |-5.46148008812119|255 |136 |0.0421444065695693 |3227 |7161 |FGFR2,RASGRF2,RPS6KA3,FGF10,MAPKAPK2,EGF,PTPN5,MKNK2,TAOK3,ARRB1,PAK1,GADD45A,NFKB1,NF1,PDGFA,MAPK8IP3,NRAS,FGF3,PLA2G4E,NTRK2,HSPA1B,FGF14,PDGFRB,RPS6KA2,FGF19,NFKB2,CDC25B,MAP3K4,FGF9,CACNG1,ATF4,HSPB1,MAPK1,CACNB3,PAK2,CACNA1E,ELK4,FAS,STK4,MAP3K13,FGFR4,DUSP16,MAP2K1,HSPA1A,MAP3K12,HSPA6,MAP3K20,MAP3K14,ECSIT,STK3,FGF1,MAP2K7,RPS6KA1,RAPGEF2,MAP4K4,IL1B,RRAS2,RASA2,FLNB,CD14,MAP2K3,HSPA8,PLA2G4C,CACNB4,CACNG6,GADD45G,MAPKAPK3,DUSP3,CACNA2D3,AKT3,KRAS,CRK,RASGRF1,CDC42,DUSP6,GNA12,DUSP7,NTF3,RASGRP4,MRAS,MAP4K3,TNFRSF1A,MAP3K1,FGF20,TRAF2,MAP3K3,MAPK14,CACNA1A,SOS1,DUSP10,JUN,CACNG4,PTPRR,IKBKG,FGFR3,RASGRP2,PPP3CA,PRKCA,PPM1B,GADD45B,PDGFRA,MAP4K2,TAB1,MAPK13,CACNA2D4,TAB2,FGF2,BRAF,FGF21,TGFBR2,FGFR1,PRKACA,GRB2,TAOK1,NR4A1,RASGRP3,MAP2K6,IL1R1,RAF1,DDIT3,DUSP1,CACNA1D,DUSP9,PPP5C,FOS,FASLG,IL1A,CRKL,DUSP5,MAP3K8,NFATC3,NLK,MAP3K5,SRF,IL1R2,TGFB3 hsa04530 |Tight junction |0.00429276197708424 |-5.45082493570163|170 |94 |0.0291292221877905 |3227 |7161 |PRKACA,SCRIB,DLG2,PPP2R1B,PCNA,PRKCE,PRKAG1,MYL6B,MICALL2,MAP2K7,RAPGEF2,EPB41L4B,CCND1,MAGI1,CLDN22,PRKAB1,TUBA3E,RAPGEF6,NEDD4L,CTTN,MYH13,TJP2,PRKAB2,RHOA,PRKAG2,CLDN4,ACTR3B,TJAP1,MYH9,PRKCI,MYL12B,ACTN1,ERBB2,MAP3K5,CLDN23,CACNA1D,ACTB,MYH1,CLDN19,PARD6G,CGN,ARHGAP17,RDX,DLG1,WHAMM,MYL6,AFDN,MPDZ,PPP2R2C,MARVELD2,ARHGEF2,LLGL2,ACTR2,PPP2R2D,MPP5,TJP3,SYNPO,CLDN1,CDC42,ACTR3C,HCLS1,MYH14,PPP2R2A,ROCK1,SRC,MYH10,ROCK2,PPP2CA,CGNL1,WASL,CLDN7,ACTN4,CDK4,PATJ,ITGB1,YBX3,ACTG1,MYL9,PRKAA1,GATA4,F11R,NEDD4,JUN,PRKCZ,ACTR3,CLDN14,RUNX1,RAB8B,MAP3K1,CLDN24,MYH4,PARD3,PARD6B,MYH11 ko04530 |Tight junction |0.00429276197708424 |-5.45082493570163|170 |94 |0.0291292221877905 |3227 |7161 |ARHGAP17,PARD6G,CGN,MYH1,CLDN19,CACNA1D,ACTB,CLDN23,MAP3K5,ACTN1,ERBB2,MYH9,PRKCI,MYL12B,ACTR3B,CLDN4,TJAP1,PRKAB2,TJP2,RHOA,PRKAG2,CTTN,MYH13,RAPGEF6,NEDD4L,CLDN22,PRKAB1,TUBA3E,MICALL2,MYL6B,MAP2K7,EPB41L4B,RAPGEF2,CCND1,MAGI1,PRKAG1,DLG2,PCNA,PPP2R1B,PRKCE,PRKACA,SCRIB,PARD6B,MYH11,PARD3,MYH4,CLDN24,MAP3K1,JUN,NEDD4,ACTR3,PRKCZ,CLDN14,RUNX1,RAB8B,PRKAA1,ACTG1,MYL9,GATA4,F11R,ACTN4,CLDN7,WASL,CDK4,PATJ,YBX3,ITGB1,PPP2CA,ROCK2,CGNL1,ROCK1,SRC,MYH10,MYH14,PPP2R2A,ACTR3C,HCLS1,CLDN1,CDC42,PPP2R2D,MPP5,SYNPO,TJP3,LLGL2,ACTR2,ARHGEF2,RDX,DLG1,WHAMM,MYL6,AFDN,MPDZ,PPP2R2C,MARVELD2 hsa04066 |HIF-1 signaling pathway |0.00454104172074963 |-5.39459883933979|101 |59 |0.0182832352029749 |3227 |7161 |EIF4E,LTBR,HK2,IFNGR1,IL6R,AKT3,CREBBP,MAP2K1,PIK3R2,PIK3R1,HMOX1,NOX1,ERBB2,VHL,HIF1A,STAT3,EIF4EBP1,SLC2A1,VEGFA,IGF1,MAPK1,PIK3CB,EGLN2,CAMK2G,EGLN3,PFKL,BCL2,PDK1,NFKB1,LDHA,ELOC,EP300,IFNGR2,TFRC,PGK1,TEK,CAMK2D,CUL2,RPS6KB2,PRKCA,SERPINE1,HKDC1,INSR,EDN1,EGF,EIF4E2,MKNK2,PLCG2,ALDOA,TF,ARNT,MTOR,CAMK2B,PIK3R3,CDKN1A,NOX3,GAPDH,CAMK2A,ANGPT4 hsa05200 |Pathways in cancer |0.00549430137390081 |-5.20404383771692|395 |203 |0.0629067245119306 |3227 |7161 |VEGFA,GLI2,PPARD,CDKN2B,AGTR1,PIK3CB,DCC,CXCR4,TRAF1,TRAF3,AKT3,BDKRB2,PIK3R2,XIAP,GNG4,ADCY3,STAT3,RALBP1,JUP,KRAS,STAT1,ARHGEF1,PTGER2,PLCB1,E2F3,LAMA5,MTOR,RARA,CTNNB1,BIRC2,ADCY4,CDKN1A,GNGT2,ELOC,EP300,BCR,KIT,FZD4,FGF1,ITGA6,STAT5A,LAMC1,ABL1,PTGER4,NFKB2,PDGFRB,FGF19,FGF14,FGF9,WNT5A,CSF3R,EPAS1,CTNNA3,COL4A5,CBLB,MAPK1,BMP4,BCL2,BIRC3,CDK4,FAS,FN1,BDKRB1,LAMB3,STK4,ROCK2,MMP9,MLH1,KITLG,RARB,MAP2K1,GNAI2,RUNX1,WNT11,HIF1A,FGFR2,HDAC2,NCOA4,FGF10,EGF,ROCK1,HSP90AA1,WNT10B,ARNT,CASP8,FZD2,RALA,PLCB4,NFKB1,FZD7,AXIN1,PDGFA,WNT7B,NRAS,FGF3,ITGA2,MSH6,GNAS,CTNNA1,RAF1,PPARG,SHH,EGLN3,FOS,HSP90AB1,TGFA,DAPK2,FASLG,E2F2,CRKL,LAMB4,PIK3R1,CDK6,ADCY9,ADCY8,PTGER1,TGFB3,ERBB2,GNG7,JAK1,PRKCA,RALGDS,ZBTB16,TPM3,TCF7L2,PDGFRA,LAMB1,ADCY7,RHOA,GNB4,PIK3R3,SMAD3,WNT3,CXCL8,RXRB,MDM2,FGF2,LPAR6,CDH1,BRAF,COL4A4,FGF21,TCF7,TGFBR2,FZD9,FGFR1,GRB2,PRKACA,PTK2,GSTP1,AXIN2,NFKBIA,RASGRP3,CCND1,MSH2,RXRA,SLC2A1,PAX8,IGF1,CYCS,EGLN2,SKP2,FGF20,ADCY1,TRAF2,PLD1,ITGB1,SOS1,CREBBP,F2RL3,GSK3B,MMP2,JUN,GNAI3,VHL,IKBKG,RASGRP2,FGFR3,RASSF1,BCL2L1,CASP9,DAPK1,CRK,VEGFD,CCNE1,SPI1,CDC42,GNB5,PTCH1,PLCG2,GNA12,LAMA3,GNG10,RASGRP4,ARHGEF12,STAT5B,RALB,GNAI1,SMAD4,FZD5,CUL2,CSF1R,CEBPA ko00480 |Glutathione metabolism |0.00598485631065308 |-5.1185229485055 |54 |34 |0.0105361016423923 |3227 |7161 |GSR,PGD,GGT5,MGST2,MGST3,GPX8,GCLM,HPGDS,GPX6,GPX5,LAP3,RRM2B,ANPEP,GPX1,GPX3,GSTP1,GSTO2,IDH1,GGT1,GPX2,IDH2,GSTA3,GPX4,TXNDC12,MGST1,GGCT,GSTA1,RRM1,GPX7,GSTO1,OPLAH,SMS,GSS,GCLC hsa00480 |Glutathione metabolism |0.00598485631065308 |-5.1185229485055 |54 |34 |0.0105361016423923 |3227 |7161 |GPX3,GSTP1,GSTO2,GGT1,GPX2,IDH1,IDH2,GSTA3,TXNDC12,GPX4,MGST1,RRM1,GSTA1,GGCT,OPLAH,SMS,GSTO1,GPX7,GSS,GCLC,GSR,PGD,GGT5,GCLM,GPX8,MGST3,MGST2,HPGDS,GPX5,GPX6,LAP3,ANPEP,RRM2B,GPX1 hsa04015 |Rap1 signaling pathway |0.00606190005595753 |-5.10573198745744|210 |113 |0.0350170436938333 |3227 |7161 |FGF3,GNAI1,GNAS,CNR1,CALM1,CSF1R,EPHA2,MRAS,RALB,PDGFA,NRAS,AFDN,SRC,RALA,ANGPT4,PLCB4,VAV2,CALM2,INSR,CSF1,FGFR2,CRK,ID1,VEGFD,FGF10,EGF,CDC42,PRKCZ,FGFR4,GNAI3,MAP2K1,GNAI2,ACTG1,SIPA1L1,RASGRP2,FGFR3,ITGB1,ITGAM,MAPK14,F2RL3,EFNA1,KITLG,PARD6B,MAPK1,ARAP3,ADCY1,FGF20,PARD3,FYB1,DOCK4,FGF14,PDGFRB,FGF19,IGF1,FGF9,RAPGEF5,MAGI3,ITGB3,RASGRP3,MAGI1,RAPGEF2,ITGB2,MAP2K6,BRAF,FGF21,KIT,PFN1,CALML5,ADORA2B,FGFR1,TEK,BCAR1,FGF1,ITGAL,RHOA,PDGFC,RAPGEF1,MAPK13,ADCY7,PIK3R3,CTNNB1,ADCY4,FGF2,THBS1,CDH1,RAPGEF6,PRKCA,RALGDS,DRD2,GRIN2A,FARP2,RAP1GAP,PDGFRA,PLCB1,PIK3R1,PIK3R2,ADCY9,ADCY3,ADCY8,SIPA1L3,KRAS,PRKCI,CRKL,AKT3,PIK3CB,EFNA5,PARD6G,RAPGEF4,RAF1,VEGFA,ACTB,PFN2,MAP2K3 ko04015 |Rap1 signaling pathway |0.00606190005595753 |-5.10573198745744|210 |113 |0.0350170436938333 |3227 |7161 |FGF3,GNAI1,CSF1R,CNR1,GNAS,CALM1,EPHA2,AFDN,NRAS,MRAS,PDGFA,RALB,SRC,CALM2,VAV2,PLCB4,ANGPT4,RALA,ID1,CSF1,INSR,FGFR2,CRK,CDC42,FGF10,VEGFD,EGF,GNAI3,MAP2K1,GNAI2,PRKCZ,FGFR4,RASGRP2,FGFR3,SIPA1L1,ACTG1,ITGAM,MAPK14,ITGB1,KITLG,EFNA1,F2RL3,MAPK1,PARD6B,PARD3,FGF20,ARAP3,ADCY1,FGF19,PDGFRB,FGF14,DOCK4,FYB1,ITGB3,RAPGEF5,IGF1,FGF9,MAGI3,MAGI1,RASGRP3,RAPGEF2,MAP2K6,ITGB2,BRAF,FGF21,ITGAL,PFN1,CALML5,ADORA2B,FGFR1,KIT,FGF1,BCAR1,TEK,CTNNB1,MAPK13,RHOA,PDGFC,ADCY7,RAPGEF1,PIK3R3,CDH1,FGF2,ADCY4,THBS1,PRKCA,RALGDS,RAPGEF6,RAP1GAP,PDGFRA,PLCB1,DRD2,GRIN2A,FARP2,PIK3R1,PIK3R2,ADCY9,SIPA1L3,KRAS,ADCY8,ADCY3,PRKCI,AKT3,CRKL,EFNA5,PIK3CB,RAPGEF4,PARD6G,VEGFA,RAF1,PFN2,MAP2K3,ACTB hsa04919 |Thyroid hormone signaling pathway |0.00653558327488652 |-5.03049368188939|116 |66 |0.020452432599938 |3227 |7161 |THRA,KRAS,PIK3R1,PIK3R2,DIO1,TBC1D4,MED30,AKT3,PDPK1,PIK3CB,ATP1A2,ACTB,ATP1A1,RHEB,MED13L,RAF1,PFKP,RCAN1,SIN3A,NOTCH1,CCND1,ATP1B3,PRKACA,MED13,EP300,NOTCH3,RXRB,MDM2,MTOR,PIK3R3,CTNNB1,PLCB1,PRKCA,STAT1,GATA4,HIF1A,ACTG1,FXYD2,MED4,GSK3B,NCOA2,MAP2K1,CREBBP,PLCD3,NCOA1,BMP4,NCOA3,ATP2A2,MAPK1,ITGB3,RXRA,SLC2A1,DIO2,ATP1B1,ESR1,NRAS,MED1,MED27,KAT2B,PLCB4,SRC,TSC2,PLCG2,SLC9A1,CASP9,HDAC2 ko05223 |Non-small cell lung cancer |0.00662442650759326 |-5.01699147574839|58 |36 |0.0111558723272389 |3227 |7161 |AKT3,STK4,SOS1,E2F2,PDPK1,TGFA,CDK4,RASSF1,KRAS,ERBB2,STAT3,MAP2K1,PIK3R1,RARB,PIK3R2,CDK6,RXRA,RAF1,MAPK1,PIK3CB,NRAS,STAT5A,GRB2,EML4,STAT5B,BRAF,CCND1,E2F3,FOXO3,EGF,PRKCA,CASP9,ALK,RXRB,PLCG2,PIK3R3 hsa05223 |Non-small cell lung cancer |0.00662442650759326 |-5.01699147574839|58 |36 |0.0111558723272389 |3227 |7161 |PIK3R3,PLCG2,ALK,RXRB,CASP9,PRKCA,EGF,E2F3,FOXO3,CCND1,BRAF,GRB2,EML4,STAT5B,NRAS,STAT5A,PIK3CB,MAPK1,RXRA,RAF1,PIK3R2,PIK3R1,RARB,CDK6,MAP2K1,STAT3,KRAS,ERBB2,RASSF1,TGFA,CDK4,PDPK1,SOS1,E2F2,STK4,AKT3 hsa05214 |Glioma |0.00748973906846849 |-4.89422131938047|64 |39 |0.0120855283545088 |3227 |7161 |CDK6,PIK3R1,PIK3R2,MAP2K1,KRAS,TGFA,CDK4,E2F2,SOS1,AKT3,PIK3CB,MAPK1,SHC3,CAMK2G,RAF1,PDGFRB,IGF1,CAMK2D,CCND1,CALM1,BRAF,PDGFA,GRB2,CALML5,NRAS,PIK3R3,CAMK2B,MTOR,SHC4,PLCG2,SHC1,MDM2,CAMK2A,CALM2,CDKN1A,PRKCA,EGF,E2F3,PDGFRA ko05214 |Glioma |0.00748973906846849 |-4.89422131938047|64 |39 |0.0120855283545088 |3227 |7161 |MDM2,SHC1,CAMK2A,CALM2,CDKN1A,PIK3R3,CAMK2B,MTOR,SHC4,PLCG2,EGF,E2F3,PDGFRA,PRKCA,CALM1,CAMK2D,CCND1,PDGFA,GRB2,CALML5,NRAS,BRAF,SHC3,CAMK2G,PIK3CB,MAPK1,IGF1,RAF1,PDGFRB,KRAS,CDK6,PIK3R1,PIK3R2,MAP2K1,E2F2,SOS1,AKT3,TGFA,CDK4 hsa00330 |Arginine and proline metabolism |0.00770568781593184 |-4.86579654541662|49 |31 |0.0096064456151224 |3227 |7161 |CNDP2,P4HA1,ALDH3A2,PYCR2,MAOB,AMD1,CNDP1,P4HA3,CKB,NOS1,SAT1,ALDH7A1,PRODH2,GAMT,ALDH4A1,HOGA1,GOT1,ALDH1B1,ARG1,PYCR1,OAT,MAOA,SMS,ALDH18A1,SMOX,LAP3,ALDH2,AZIN2,AGMAT,GOT2,GATM ko00330 |Arginine and proline metabolism |0.00770568781593184 |-4.86579654541662|49 |31 |0.0096064456151224 |3227 |7161 |NOS1,SAT1,ALDH7A1,PRODH2,ALDH4A1,GAMT,HOGA1,GOT1,ALDH1B1,ARG1,PYCR1,CNDP2,P4HA1,PYCR2,ALDH3A2,MAOB,AMD1,CNDP1,P4HA3,CKB,ALDH2,AZIN2,AGMAT,GOT2,GATM,MAOA,OAT,ALDH18A1,SMS,SMOX,LAP3 ko00564 |Glycerophospholipid metabolism |0.00774966850763175 |-4.86010520974049|95 |55 |0.0170436938332817 |3227 |7161 |PLA2G6,PLA2G2A,LPCAT1,LPIN1,AGPAT2,GPD2,CHKA,PLA2G4E,GPAM,DGKA,CDS2,AGPAT4,GPCPD1,LCAT,PLPP3,CHPT1,GPAT3,PCYT1B,LPIN3,LYPLA1,ETNK1,GPAT2,PEMT,LPIN2,GPD1,PLPP1,CDIPT,AGPAT1,PLB1,CRLS1,ETNPPL,PLD1,DGKD,ACHE,PLA2G15,MBOAT1,PLA2G1B,DGKE,DGKZ,AGPAT3,DGKK,CEPT1,LCLAT1,PGS1,ETNK2,GNPAT,DGKI,GPD1L,PISD,GPAT4,PCYT1A,SELENOI,PLA2G4C,PNPLA7,DGKQ hsa00564 |Glycerophospholipid metabolism |0.00774966850763175 |-4.86010520974049|95 |55 |0.0170436938332817 |3227 |7161 |PNPLA7,SELENOI,PCYT1A,PLA2G4C,DGKQ,PISD,GPAT4,GPD1L,GNPAT,DGKI,ETNK2,PGS1,CEPT1,LCLAT1,DGKK,AGPAT3,DGKZ,MBOAT1,PLA2G1B,DGKE,PLA2G15,ETNPPL,CRLS1,DGKD,PLD1,ACHE,AGPAT1,PLB1,GPD1,CDIPT,PLPP1,PEMT,LPIN2,GPAT2,ETNK1,LYPLA1,CHPT1,LPIN3,PCYT1B,GPAT3,GPCPD1,LCAT,AGPAT4,PLPP3,GPAM,DGKA,CDS2,PLA2G4E,CHKA,AGPAT2,GPD2,PLA2G2A,LPCAT1,LPIN1,PLA2G6 ko04070 |Phosphatidylinositol signaling system |0.00784720331718293 |-4.8475980759924 |97 |56 |0.017353579175705 |3227 |7161 |INPP5A,CALML5,PIP4P1,MTMR14,PIP4K2A,INPP1,IP6K3,CDS2,MTMR2,DGKA,ITPK1,CALM1,PIP5K1A,ITPKB,PLCB1,PIK3C2G,ITPR3,PIP5K1B,PRKCA,MTM1,PIK3C2A,PLCB4,CALM2,CDIPT,PLCG2,PIK3R3,OCRL,PLCD3,PIK3C2B,DGKE,SYNJ2,INPP5D,DGKD,MTMR4,PIKFYVE,PIK3C3,DGKK,PI4K2A,ITPKC,PI4KB,DGKZ,ITPR2,PIK3R2,PIK3R1,DGKI,PIP4P2,IMPA2,MTMR3,DGKQ,IP6K2,ITPR1,INPP4A,MTMR7,PI4KA,PIK3CB,INPP5B ko04750 |Inflammatory mediator regulation of TRP channels |0.00784720331718293 |-4.8475980759924 |97 |56 |0.017353579175705 |3227 |7161 |TRPV2,ADCY3,ADCY8,ASIC2,ADCY9,IL1RAP,BDKRB2,PIK3R2,PIK3R1,ITPR2,BDKRB1,MAPK14,ITPR1,ADCY1,PLA2G4C,CAMK2G,PIK3CB,PRKCH,IGF1,TRPM8,MAP2K3,IL1B,HTR2A,CALM1,PTGER4,P2RY2,GNAS,IL1R1,MAP2K6,PLA2G4E,CAMK2D,PRKACA,PPP1CC,CALML5,HTR2B,PLA2G6,PRKCE,PRKCD,TRPV4,ADCY4,CAMK2A,CALM2,PLCB4,CYP2J2,PIK3R3,PPP1CB,MAPK13,CAMK2B,ADCY7,SRC,ASIC1,PLCG2,ITPR3,PTGER2,PLCB1,PRKCA hsa04070 |Phosphatidylinositol signaling system |0.00784720331718293 |-4.8475980759924 |97 |56 |0.017353579175705 |3227 |7161 |MTMR7,ITPR1,INPP4A,IP6K2,DGKQ,INPP5B,PIK3CB,PI4KA,IMPA2,PIP4P2,DGKI,MTMR3,PI4KB,ITPKC,PI4K2A,DGKK,PIK3R1,PIK3R2,ITPR2,DGKZ,PIK3C2B,DGKE,PLCD3,OCRL,MTMR4,PIKFYVE,DGKD,PIK3C3,INPP5D,SYNJ2,CDIPT,CALM2,PLCB4,PIK3C2A,PIK3R3,PLCG2,ITPR3,PIK3C2G,PLCB1,MTM1,PRKCA,PIP5K1B,PIP5K1A,CALM1,ITPK1,IP6K3,DGKA,CDS2,MTMR2,ITPKB,CALML5,INPP5A,INPP1,PIP4K2A,MTMR14,PIP4P1 hsa04750 |Inflammatory mediator regulation of TRP channels |0.00784720331718293 |-4.8475980759924 |97 |56 |0.017353579175705 |3227 |7161 |MAPK14,BDKRB1,ITPR2,ADCY9,PIK3R1,BDKRB2,IL1RAP,PIK3R2,ADCY3,TRPV2,ADCY8,ASIC2,IL1B,HTR2A,TRPM8,MAP2K3,IGF1,PRKCH,PIK3CB,PLA2G4C,CAMK2G,ADCY1,ITPR1,PLA2G6,PRKCE,PRKCD,PPP1CC,PRKACA,HTR2B,CALML5,PLA2G4E,CAMK2D,MAP2K6,IL1R1,PTGER4,CALM1,P2RY2,GNAS,PRKCA,PLCB1,ITPR3,PTGER2,PLCG2,PPP1CB,PIK3R3,CYP2J2,ADCY7,CAMK2B,SRC,ASIC1,MAPK13,CALM2,PLCB4,TRPV4,ADCY4,CAMK2A hsa05016 |Huntington's disease |0.00795329776757417 |-4.8341686227959 |187 |101 |0.0312984195847536 |3227 |7161 |AP2A1,ATP5F1C,EP300,CREB5,DCTN4,COX7A2,REST,DNAH14,NDUFB6,COX5B,AP2M1,NDUFB7,ATP5F1A,SIN3A,HIP1,VDAC3,SOD1,NDUFB3,TFAM,PLCB1,PPIF,CREB1,IFT57,DCTN2,AP2B1,DNAH12,NDUFS7,COX6B1,DNAH6,AP2A2,UQCRB,DNAH10,UQCRFS1,PPARGC1A,NDUFS5,NDUFB4,CREB3L1,COX7A2L,VDAC1,COX4I1,PPARG,ATP5PF,COX6A1,AP2S1,ATP5F1D,NDUFA4,GPX1,RCOR1,POLR2D,UQCR10,TBPL2,COX6C,SOD2,DNAH17,CREB3L2,ATP5MC3,COX4I2,DNAL4,CREB3L3,DCTN1,NDUFS1,NDUFC1,NDUFV2,CASP9,NDUFA12,HDAC2,TBPL1,NDUFA11,COX8A,NDUFB9,TGM2,ATP5MC2,PLCB4,VDAC2,CASP8,BBC3,DNAH7,DNAH3,UQCRC1,CREB3,SLC25A4,NDUFAB1,UQCRC2,TAF4,COX5A,CREBBP,SDHB,TBP,ATP5MC1,UQCRHL,NRF1,NDUFB11,POLR2A,POLR2E,CREB3L4,NDUFS4,NDUFA8,DNAH11,CYCS,ATP5PO,ITPR1 ko05016 |Huntington's disease |0.00795329776757417 |-4.8341686227959 |187 |101 |0.0312984195847536 |3227 |7161 |ATP5F1C,EP300,AP2A1,DCTN4,COX7A2,CREB5,NDUFB6,DNAH14,AP2M1,COX5B,REST,ATP5F1A,HIP1,SIN3A,NDUFB7,SOD1,VDAC3,NDUFB3,TFAM,PLCB1,PPIF,CREB1,AP2B1,DCTN2,IFT57,COX6B1,NDUFS7,DNAH12,UQCRB,AP2A2,DNAH6,PPARGC1A,DNAH10,UQCRFS1,VDAC1,NDUFS5,NDUFB4,CREB3L1,COX7A2L,COX4I1,COX6A1,ATP5PF,PPARG,GPX1,RCOR1,POLR2D,ATP5F1D,NDUFA4,AP2S1,UQCR10,DNAH17,TBPL2,SOD2,COX6C,COX4I2,CREB3L2,ATP5MC3,DNAL4,NDUFS1,NDUFC1,CREB3L3,DCTN1,NDUFV2,CASP9,HDAC2,NDUFA12,NDUFB9,TBPL1,NDUFA11,COX8A,ATP5MC2,TGM2,DNAH7,BBC3,CASP8,PLCB4,VDAC2,CREB3,DNAH3,UQCRC1,TAF4,COX5A,CREBBP,SDHB,SLC25A4,NDUFAB1,UQCRC2,TBP,ATP5MC1,UQCRHL,NRF1,POLR2A,POLR2E,NDUFB11,NDUFS4,NDUFA8,DNAH11,CREB3L4,CYCS,ATP5PO,ITPR1 M00089 |Triacylglycerol biosynthesis |0.00868226821400879 |-4.74647246946872|17 |13 |0.00402850945150294 |3227 |7161 |PLPP3,PLPP1,LCLAT1,AGPAT4,GPAM,GPAT4,AGPAT3,GPAT2,MBOAT1,AGPAT2,DGAT1,AGPAT1,GPAT3 hsa_M00089|Triacylglycerol biosynthesis |0.00868226821400879 |-4.74647246946872|17 |13 |0.00402850945150294 |3227 |7161 |GPAT3,AGPAT1,AGPAT2,MBOAT1,DGAT1,GPAT2,GPAT4,AGPAT3,GPAM,LCLAT1,PLPP3,PLPP1,AGPAT4 ko04210 |Apoptosis |0.0108987023616859 |-4.51911154622059|138 |76 |0.0235512860241711 |3227 |7161 |CFLAR,TUBA3E,ITPR3,GADD45B,CAPN1,RIPK1,BIRC2,DIABLO,PIK3R3,MAP3K14,LMNA,NFKBIA,CTSD,TNFRSF10C,CAPN2,IL3,ACTB,PARP1,DDIT3,RAF1,TRAF1,DAB2IP,SPTAN1,BCL2L11,PIK3CB,TNFRSF10B,AKT3,MCL1,FASLG,ERN1,GADD45G,PDPK1,CASP10,FOS,KRAS,BCL2A1,CTSB,XIAP,PIK3R2,MAP3K5,PIK3R1,TNFRSF10D,CASP9,CTSO,GADD45A,BBC3,CASP8,NRAS,PRF1,PARP2,NFKB1,EIF2AK3,TNFRSF1A,CTSZ,CTSL,LMNB1,BIRC3,TRAF2,CTSH,ITPR1,BCL2,MAPK1,ATF4,CYCS,TNFSF10,CTSC,FAS,ATM,BCL2L1,IKBKG,ACTG1,ITPR2,MAP2K1,SEPTIN4,JUN,LMNB2 hsa04210 |Apoptosis |0.0108987023616859 |-4.51911154622059|138 |76 |0.0235512860241711 |3227 |7161 |BCL2L1,ATM,IKBKG,ACTG1,SEPTIN4,MAP2K1,ITPR2,LMNB2,JUN,TNFSF10,CTSC,FAS,BIRC3,TRAF2,ITPR1,BCL2,CTSH,ATF4,MAPK1,CYCS,CTSL,LMNB1,CTSZ,TNFRSF1A,EIF2AK3,NRAS,PRF1,PARP2,NFKB1,CTSO,GADD45A,CASP8,BBC3,CASP9,TNFRSF10D,KRAS,CTSB,BCL2A1,XIAP,PIK3R1,PIK3R2,MAP3K5,MCL1,AKT3,ERN1,FASLG,CASP10,PDPK1,GADD45G,FOS,TRAF1,DAB2IP,BCL2L11,SPTAN1,PIK3CB,TNFRSF10B,IL3,ACTB,DDIT3,PARP1,RAF1,CAPN2,NFKBIA,CTSD,TNFRSF10C,BIRC2,RIPK1,DIABLO,LMNA,MAP3K14,PIK3R3,TUBA3E,CFLAR,ITPR3,GADD45B,CAPN1 ko05203 |Viral carcinogenesis |0.0111886525731795 |-4.49285517738674|201 |107 |0.0331577316392935 |3227 |7161 |RASA2,HIST1H4D,HDAC5,CDKN2B,ATP6V0D1,PIK3CB,HDAC4,TRAF1,YWHAB,MAD1L1,USP7,TRAF3,CHEK1,YWHAQ,C3,HPN,REL,SRF,PIK3R1,PIK3R2,CDK6,CREB3L1,KRAS,STAT3,ACTN1,VDAC3,JAK1,HIST1H2BJ,IL6ST,HIST1H2BH,EGR3,RHOA,PIK3R3,CREB1,CDKN1A,RBPJ,YWHAZ,MDM2,CCR8,HIST1H4I,EP300,SCRIB,CREB5,NFKBIA,STAT5A,LYN,GRB2,PRKACA,CCND1,HIST1H4H,HIST1H2BL,DDX3X,ATP6V0D2,HIST1H4E,NFKB2,YWHAG,CREB3L4,ATF4,MAPK1,CCNA2,HDAC8,TRAF2,SKP2,LTBR,CDK4,PKM,CREB3,ACTN4,GSN,CREBBP,CDC20,TBP,HIST1H2BC,CCR4,JUN,IRF9,RBL2,CCND3,IKBKG,HIST1H2BO,GTF2A1,HDAC2,TBPL1,CDC42,CCNE1,MAPKAPK2,SP100,SRC,DNAJA3,HIST1H4K,CASP8,KAT2B,TBPL2,GTF2B,NFKB1,RBL1,NRAS,CREB3L2,STAT5B,DLG1,POLB,MRPS18B,VAC14,HDAC11,PXN,CREB3L3,HIST1H4B hsa05203 |Viral carcinogenesis |0.0111886525731795 |-4.49285517738674|201 |107 |0.0331577316392935 |3227 |7161 |GTF2A1,HIST1H2BO,HDAC2,TBPL1,CDC42,CCNE1,MAPKAPK2,SP100,SRC,DNAJA3,HIST1H4K,CASP8,KAT2B,TBPL2,GTF2B,RBL1,NFKB1,CREB3L2,NRAS,STAT5B,DLG1,POLB,MRPS18B,HDAC11,VAC14,CREB3L3,PXN,HIST1H4B,NFKB2,HIST1H4E,YWHAG,CREB3L4,ATF4,MAPK1,HDAC8,CCNA2,TRAF2,SKP2,LTBR,CDK4,PKM,CREB3,ACTN4,GSN,CREBBP,CDC20,TBP,HIST1H2BC,CCR4,JUN,IRF9,RBL2,CCND3,IKBKG,VDAC3,HIST1H2BJ,JAK1,IL6ST,HIST1H2BH,EGR3,RHOA,CREB1,PIK3R3,CDKN1A,RBPJ,MDM2,YWHAZ,CCR8,HIST1H4I,EP300,CREB5,SCRIB,NFKBIA,STAT5A,LYN,PRKACA,GRB2,HIST1H4H,CCND1,DDX3X,HIST1H2BL,ATP6V0D2,RASA2,HIST1H4D,HDAC5,CDKN2B,ATP6V0D1,PIK3CB,HDAC4,YWHAB,TRAF1,MAD1L1,USP7,TRAF3,C3,YWHAQ,CHEK1,HPN,REL,SRF,PIK3R1,PIK3R2,CDK6,CREB3L1,KRAS,STAT3,ACTN1 ko05220 |Chronic myeloid leukemia |0.0115057677560775 |-4.46490682533735|71 |42 |0.0130151843817787 |3227 |7161 |TGFBR2,BRAF,NFKB1,NRAS,ABL1,STAT5A,NFKBIA,STAT5B,BCR,GRB2,CCND1,SMAD4,CRK,HDAC2,E2F3,SHC4,SMAD3,PIK3R3,CDKN1A,MDM2,SHC1,CDK4,AKT3,E2F2,SOS1,CRKL,MAP2K1,RUNX1,PIK3R1,CDK6,PIK3R2,PTPN11,BCL2L1,KRAS,IKBKG,TGFB3,RAF1,GAB2,CBLB,MAPK1,PIK3CB,SHC3 hsa05220 |Chronic myeloid leukemia |0.0115057677560775 |-4.46490682533735|71 |42 |0.0130151843817787 |3227 |7161 |CCND1,SMAD4,ABL1,STAT5A,NRAS,NFKBIA,GRB2,STAT5B,BCR,TGFBR2,NFKB1,BRAF,CDKN1A,MDM2,SHC1,SHC4,PIK3R3,SMAD3,E2F3,HDAC2,CRK,KRAS,BCL2L1,PTPN11,IKBKG,TGFB3,RUNX1,MAP2K1,PIK3R2,CDK6,PIK3R1,AKT3,CRKL,E2F2,SOS1,CDK4,SHC3,MAPK1,CBLB,PIK3CB,GAB2,RAF1 hsa00260 |Glycine, serine and threonine metabolism |0.0127844108330936 |-4.35952875396852|39 |25 |0.00774713356058258 |3227 |7161 |PHGDH,SHMT2,PIPOX,GLYCTK,CTH,PSAT1,GATM,AGXT,GLDC,ALAS1,MAOA,AGXT2,GAMT,SARDH,ALDH7A1,SDSL,CHDH,GNMT,MAOB,DMGDH,PSPH,GCSH,AOC3,BPGM,GRHPR ko00260 |Glycine, serine and threonine metabolism |0.0127844108330936 |-4.35952875396852|39 |25 |0.00774713356058258 |3227 |7161 |SHMT2,PIPOX,PHGDH,AGXT,GLYCTK,CTH,PSAT1,GATM,MAOA,ALAS1,GLDC,ALDH7A1,SARDH,AGXT2,GAMT,SDSL,CHDH,DMGDH,PSPH,MAOB,GNMT,AOC3,GCSH,BPGM,GRHPR hsa04917 |Prolactin signaling pathway |0.0155083124530617 |-4.16637911151327|70 |41 |0.0127052990393554 |3227 |7161 |NFKB1,IRF1,TNFRSF11A,GRB2,STAT5B,NRAS,ESR1,STAT5A,CCND1,SOCS2,STAT1,SOCS1,FOXO3,JAK2,GALT,PIK3R3,MAPK13,SRC,SHC4,SHC1,FOS,MAPK14,SOS1,AKT3,SOCS6,GSK3B,PIK3R2,PIK3R1,SOCS3,MAP2K1,STAT3,CISH,KRAS,RAF1,PRLR,SLC2A2,ELF5,GCK,PIK3CB,MAPK1,SHC3 ko04917 |Prolactin signaling pathway |0.0155083124530617 |-4.16637911151327|70 |41 |0.0127052990393554 |3227 |7161 |AKT3,SOS1,MAPK14,FOS,KRAS,STAT3,CISH,SOCS3,MAP2K1,SOCS6,PIK3R2,PIK3R1,GSK3B,SLC2A2,ELF5,GCK,PRLR,RAF1,SHC3,MAPK1,PIK3CB,STAT5A,ESR1,NRAS,GRB2,STAT5B,IRF1,TNFRSF11A,NFKB1,CCND1,SOCS2,FOXO3,JAK2,STAT1,SOCS1,SHC1,SHC4,PIK3R3,GALT,MAPK13,SRC ko00600 |Sphingolipid metabolism |0.0158021178857187 |-4.14761130453231|47 |29 |0.0089866749302758 |3227 |7161 |PLPP1,CERS2,NEU4,ACER2,SGPL1,SMPD1,SGMS1,SGPP1,DEGS2,ACER3,SPTLC3,KDSR,SGMS2,PLPP3,ENPP7,SPTLC2,ASAH2,CERS4,GBA,CERK,GLB1,NEU3,ACER1,SPHK2,NEU1,CERS6,ARSA,DEGS1,SPHK1 hsa00600 |Sphingolipid metabolism |0.0158021178857187 |-4.14761130453231|47 |29 |0.0089866749302758 |3227 |7161 |NEU4,CERS2,PLPP1,SGMS1,SGPP1,ACER2,SGPL1,SMPD1,ACER3,SPTLC3,DEGS2,KDSR,SGMS2,ENPP7,SPTLC2,GBA,ASAH2,CERS4,PLPP3,NEU3,GLB1,ACER1,SPHK2,CERK,CERS6,NEU1,SPHK1,DEGS1,ARSA ko05100 |Bacterial invasion of epithelial cells |0.0162102837162875 |-4.12210944084068|76 |44 |0.0136349550666253 |3227 |7161 |CTNNA3,PIK3CB,CBLB,SHC3,ARHGEF26,CTNNA1,DNM2,WASF2,ACTB,DOCK1,ELMO1,PIK3R1,PIK3R2,ACTG1,ARPC5L,WASL,WASF1,SEPTIN6,ITGB1,FN1,CRKL,CAV1,PIK3R3,RHOA,SRC,VCL,CTNNB1,SHC4,CTTN,SHC1,CDH1,CRK,HCLS1,RHOG,CDC42,SEPTIN2,ARPC5,SEPTIN9,ARPC2,ARPC1A,PXN,BCAR1,ARPC1B,PTK2 hsa05100 |Bacterial invasion of epithelial cells |0.0162102837162875 |-4.12210944084068|76 |44 |0.0136349550666253 |3227 |7161 |CDH1,SHC1,CTTN,CTNNB1,SHC4,VCL,PIK3R3,SRC,RHOA,CDC42,RHOG,CRK,HCLS1,ARPC2,ARPC1A,PXN,SEPTIN9,ARPC5,SEPTIN2,PTK2,BCAR1,ARPC1B,SHC3,CBLB,CTNNA3,PIK3CB,ACTB,DOCK1,WASF2,DNM2,ARHGEF26,CTNNA1,ARPC5L,ACTG1,ELMO1,PIK3R2,PIK3R1,CAV1,CRKL,ITGB1,SEPTIN6,FN1,WASL,WASF1 hsa04350 |TGF-beta signaling pathway |0.0168890202280161 |-4.08109155884347|84 |48 |0.0148744964363186 |3227 |7161 |ID1,SMAD7,BMP6,RPS6KB2,ID4,FST,LTBP1,INHBE,SMAD3,ROCK1,SMAD9,SMURF1,RHOA,THBS1,NOG,TGFBR2,PPP2R1B,SMAD5,EP300,CUL1,RBL1,NODAL,INHBB,SMURF2,ACVR1B,SMAD4,INHBC,ACVR2A,GDF7,BMPR2,SMAD1,CDKN2B,ID2,MAPK1,NBL1,SMAD6,BMP8A,ZFYVE16,ACVR1,BMP4,BMPR1A,LEFTY1,PPP2CA,SKP1,CREBBP,E2F5,TGIF1,TGFB3 ko04350 |TGF-beta signaling pathway |0.0168890202280161 |-4.08109155884347|84 |48 |0.0148744964363186 |3227 |7161 |ACVR1B,SMAD4,INHBC,ACVR2A,GDF7,NOG,PPP2R1B,TGFBR2,SMAD5,EP300,CUL1,RBL1,NODAL,INHBB,SMURF2,INHBE,SMAD9,ROCK1,SMAD3,RHOA,SMURF1,THBS1,ID1,BMP6,RPS6KB2,SMAD7,ID4,LTBP1,FST,E2F5,TGIF1,TGFB3,BMPR1A,LEFTY1,PPP2CA,SKP1,CREBBP,ID2,MAPK1,NBL1,SMAD6,BMP8A,ZFYVE16,ACVR1,BMP4,BMPR2,CDKN2B,SMAD1 hsa04666 |Fc gamma R-mediated phagocytosis |0.0172342356820953 |-4.06085742684346|90 |51 |0.0158041524635885 |3227 |7161 |DNM2,LIMK2,RAF1,FCGR3A,MARCKSL1,WASF2,GAB2,MAPK1,CFL2,PIK3CB,INPP5D,SPHK1,WASL,WASF1,ARF6,PLD1,AKT3,CRKL,GSN,MAP2K1,SPHK2,VAV3,PIK3R1,PIK3R2,ARPC5L,PIP5K1B,RPS6KB2,PRKCA,CRK,CDC42,FCGR2A,PLCG2,ASAP2,PIK3R3,VAV2,PAK1,BIN1,PLPP1,PLA2G6,PRKCD,PRKCE,LYN,ASAP3,ARPC1B,ARPC5,ASAP1,PLA2G4E,ARPC1A,ARPC2,PIP5K1A,PLPP3 ko04666 |Fc gamma R-mediated phagocytosis |0.0172342356820953 |-4.06085742684346|90 |51 |0.0158041524635885 |3227 |7161 |VAV3,PIK3R2,PIK3R1,SPHK2,MAP2K1,ARPC5L,WASL,PLD1,ARF6,WASF1,INPP5D,SPHK1,CRKL,GSN,AKT3,CFL2,PIK3CB,MAPK1,RAF1,DNM2,LIMK2,MARCKSL1,GAB2,WASF2,FCGR3A,PLA2G4E,ASAP1,ARPC5,PIP5K1A,PLPP3,ARPC2,ARPC1A,PLA2G6,PRKCD,PRKCE,ARPC1B,LYN,ASAP3,PIK3R3,ASAP2,PLCG2,PLPP1,BIN1,PAK1,VAV2,CRK,PRKCA,RPS6KB2,PIP5K1B,FCGR2A,CDC42 hsa04110 |Cell cycle |0.0174020132428218 |-4.05116937584435|124 |68 |0.0210722032847846 |3227 |7161 |YWHAB,MAD1L1,CDKN2B,TFDP2,TGFB3,ATR,CDK6,STAG1,E2F2,YWHAQ,CHEK1,GADD45G,BUB1,CDKN1A,FZR1,MDM2,YWHAZ,CDC14B,SMAD3,E2F3,GADD45B,ORC4,CCND1,CDC6,MCM5,ABL1,BUB3,PCNA,CUL1,EP300,BUB1B,SKP2,ESPL1,ANAPC4,CCNA2,ORC2,CDC25B,YWHAG,RBL2,ATM,CDKN2D,CCND3,CDC20,ORC1,E2F5,ANAPC7,ORC6,GSK3B,MCM4,CREBBP,CDC7,SKP1,ZBTB17,CDK4,GADD45A,WEE1,CCNE1,HDAC2,PRKDC,ORC5,PTTG2,MCM3,SMAD4,CCNH,CHEK2,RBL1,RAD21,PLK1 ko04110 |Cell cycle |0.0174020132428218 |-4.05116937584435|124 |68 |0.0210722032847846 |3227 |7161 |ORC2,CDC25B,YWHAG,ESPL1,ANAPC4,CCNA2,BUB1B,SKP2,CDK4,ZBTB17,MCM4,CREBBP,SKP1,CDC7,CDC20,E2F5,ANAPC7,ORC1,ORC6,GSK3B,ATM,RBL2,CDKN2D,CCND3,HDAC2,WEE1,CCNE1,GADD45A,CHEK2,PLK1,RBL1,RAD21,CCNH,MCM3,SMAD4,PRKDC,PTTG2,ORC5,CDKN2B,YWHAB,MAD1L1,YWHAQ,CHEK1,GADD45G,STAG1,E2F2,ATR,CDK6,TFDP2,TGFB3,GADD45B,E2F3,CDC14B,SMAD3,BUB1,CDKN1A,FZR1,MDM2,YWHAZ,BUB3,PCNA,CUL1,EP300,CDC6,MCM5,ABL1,CCND1,ORC4 ko05130 |Pathogenic Escherichia coli infection |0.0181061657578485 |-4.01150274911337|55 |33 |0.010226216299969 |3227 |7161 |KRT18,ARPC1B,ABL1,TUBB1,ARHGEF2,LY96,ARPC1A,ARPC2,TUBB,ARPC5,CLDN1,CDC42,TUBA3E,HCLS1,PRKCA,YWHAZ,CTTN,CDH1,ROCK1,RHOA,NCK1,CTNNB1,ROCK2,WASL,YWHAQ,ITGB1,ACTG1,NCK2,ARPC5L,ACTB,CD14,TLR5,FYN hsa05221 |Acute myeloid leukemia |0.0181061657578485 |-4.01150274911337|55 |33 |0.010226216299969 |3227 |7161 |RUNX1,MAP2K1,PIK3R1,PIK3R2,PIM1,JUP,KRAS,EIF4EBP1,IKBKG,STAT3,AKT3,SOS1,MAPK1,PIK3CB,RAF1,PPARD,CCND1,CEBPA,TCF7,BRAF,NFKB1,NRAS,STAT5A,GRB2,KIT,STAT5B,RARA,PIK3R3,MTOR,RPS6KB2,TCF7L2,SPI1,ZBTB16 ko05221 |Acute myeloid leukemia |0.0181061657578485 |-4.01150274911337|55 |33 |0.010226216299969 |3227 |7161 |PIK3R3,MTOR,RARA,RPS6KB2,TCF7L2,SPI1,ZBTB16,CCND1,CEBPA,BRAF,NFKB1,TCF7,GRB2,STAT5B,KIT,NRAS,STAT5A,PIK3CB,MAPK1,RAF1,PPARD,PIK3R1,PIK3R2,RUNX1,MAP2K1,EIF4EBP1,IKBKG,STAT3,KRAS,JUP,PIM1,SOS1,AKT3 hsa05130 |Pathogenic Escherichia coli infection |0.0181061657578485 |-4.01150274911337|55 |33 |0.010226216299969 |3227 |7161 |TUBB1,ARHGEF2,ARPC1B,KRT18,ABL1,ARPC5,TUBB,LY96,ARPC2,ARPC1A,HCLS1,PRKCA,CLDN1,TUBA3E,CDC42,RHOA,ROCK1,NCK1,CTNNB1,YWHAZ,CTTN,CDH1,WASL,ITGB1,YWHAQ,ROCK2,NCK2,ACTG1,ARPC5L,FYN,ACTB,TLR5,CD14 ko00770 |Pantothenate and CoA biosynthesis |0.0184154264442473 |-3.9945665719138 |18 |13 |0.00402850945150294 |3227 |7161 |PPCDC,BCAT2,PANK1,AASDHPPT,COASY,DPYS,UPB1,BCAT1,GADL1,ENPP3,PANK3,PANK2,ENPP1 hsa01210 |2-Oxocarboxylic acid metabolism |0.0184154264442473 |-3.9945665719138 |18 |13 |0.00402850945150294 |3227 |7161 |GPT,BCAT1,IDH3A,GOT2,GOT1,ACO1,IDH1,ACO2,CS,AADAT,GPT2,IDH2,BCAT2 hsa00770 |Pantothenate and CoA biosynthesis |0.0184154264442473 |-3.9945665719138 |18 |13 |0.00402850945150294 |3227 |7161 |DPYS,UPB1,PPCDC,BCAT2,COASY,AASDHPPT,PANK1,GADL1,BCAT1,PANK2,ENPP3,PANK3,ENPP1 ko01210 |2-Oxocarboxylic acid metabolism |0.0184154264442473 |-3.9945665719138 |18 |13 |0.00402850945150294 |3227 |7161 |IDH2,BCAT2,CS,GPT2,AADAT,IDH1,ACO2,ACO1,GOT1,GPT,GOT2,BCAT1,IDH3A ko00380 |Tryptophan metabolism |0.019690490196123 |-3.92761949095166|40 |25 |0.00774713356058258 |3227 |7161 |IDO2,AANAT,ALDH2,OGDH,KYAT3,DDC,HADH,MAOA,ALDH1B1,HAAO,ALDH7A1,AFMID,ACMSD,AOX1,HADHA,TPH2,CYP1A1,ACAT2,KYAT1,KYNU,ASMT,CAT,AADAT,MAOB,ALDH3A2 hsa00380 |Tryptophan metabolism |0.019690490196123 |-3.92761949095166|40 |25 |0.00774713356058258 |3227 |7161 |CYP1A1,KYAT1,ACAT2,KYNU,ASMT,CAT,AADAT,MAOB,ALDH3A2,ALDH1B1,HAAO,ALDH7A1,AFMID,AOX1,ACMSD,TPH2,HADHA,DDC,HADH,MAOA,IDO2,AANAT,ALDH2,KYAT3,OGDH ko00830 |Retinol metabolism |0.0201343584621101 |-3.90532754701348|65 |38 |0.0117756430120855 |3227 |7161 |CYP1A1,ADH5,RETSAT,RDH10,DHRS4L2,CYP2S1,RDH12,CYP26B1,CYP2C18,CYP2A6,UGT2B15,DHRS4L1,UGT1A5,CYP3A4,DGAT1,PNPLA4,DHRS3,ALDH1A2,CYP2B6,UGT2A3,ADH4,UGT2B10,UGT2B7,CYP26C1,CYP3A7-CYP3A51P,RDH16,CYP2C9,UGT2B4,AOX1,ADH6,RDH11,ALDH1A1,ADH7,DHRS4,CYP2C8,HSD17B6,CYP26A1,UGT1A4 hsa00830 |Retinol metabolism |0.0201343584621101 |-3.90532754701348|65 |38 |0.0117756430120855 |3227 |7161 |DHRS4,ALDH1A1,RDH11,ADH6,ADH7,UGT1A4,HSD17B6,CYP26A1,CYP2C8,UGT2A3,ADH4,UGT2B4,CYP2C9,RDH16,AOX1,UGT2B7,UGT2B10,CYP3A7-CYP3A51P,CYP26C1,UGT1A5,DHRS4L1,ALDH1A2,DHRS3,CYP2B6,PNPLA4,CYP3A4,DGAT1,RETSAT,DHRS4L2,RDH10,ADH5,CYP1A1,CYP2C18,CYP26B1,UGT2B15,CYP2A6,RDH12,CYP2S1 hsa04610 |Complement and coagulation cascades |0.0217542278762991 |-3.82794715522058|79 |45 |0.0139448404090487 |3227 |7161 |SERPINE1,SERPINF2,PROC,FGG,KNG1,TFPI,FGA,CFD,CPB2,SERPINC1,C2,CFB,A2M,ITGB2,C1S,CLU,VTN,F2,F11,C5,PROS1,SERPINA1,F13A1,C1R,C8B,C5AR1,C8A,SERPIND1,ITGAX,F5,F10,FGB,F2RL3,ITGAM,C3,BDKRB1,CD55,C4BPA,SERPINA5,C4BPB,MBL2,VWF,F7,SERPINB2,BDKRB2 ko04610 |Complement and coagulation cascades |0.0217542278762991 |-3.82794715522058|79 |45 |0.0139448404090487 |3227 |7161 |CLU,VTN,F2,F11,C5,SERPINA1,PROS1,C1R,F13A1,C8B,C5AR1,C8A,SERPIND1,ITGAX,F10,F5,FGB,F2RL3,BDKRB1,CD55,C3,ITGAM,C4BPA,SERPINA5,C4BPB,MBL2,VWF,F7,SERPINB2,BDKRB2,SERPINF2,SERPINE1,FGG,PROC,KNG1,TFPI,FGA,CFD,C2,SERPINC1,CPB2,CFB,A2M,ITGB2,C1S hsa05231 |Choline metabolism in cancer |0.0224163065230761 |-3.79796661518243|99 |55 |0.0170436938332817 |3227 |7161 |PIK3R3,MTOR,TSC2,PDGFC,PLPP1,LYPLA1,RALGDS,CHPT1,PIP5K1B,RPS6KB2,PRKCA,PCYT1B,EGF,PDGFRA,PLA2G4E,CHKA,PIP5K1A,GPCPD1,PLPP3,DGKA,GRB2,PDGFA,NRAS,PIK3CB,MAPK1,PLA2G4C,PCYT1A,DGKQ,RAF1,SLC44A1,PDGFRB,WASF2,RHEB,DGKI,JUN,PIK3R1,PIK3R2,DGKZ,MAP2K1,HIF1A,EIF4EBP1,KRAS,DGKK,WASL,FOS,WASF1,DGKD,PLD1,PDPK1,SLC22A3,SLC44A5,DGKE,SLC22A2,SOS1,AKT3 ko05231 |Choline metabolism in cancer |0.0224163065230761 |-3.79796661518243|99 |55 |0.0170436938332817 |3227 |7161 |GPCPD1,PIP5K1A,PLPP3,DGKA,PLA2G4E,CHKA,PDGFA,GRB2,NRAS,PLPP1,PIK3R3,TSC2,PDGFC,MTOR,EGF,PDGFRA,LYPLA1,RALGDS,CHPT1,PIP5K1B,PCYT1B,PRKCA,RPS6KB2,HIF1A,EIF4EBP1,KRAS,DGKK,JUN,PIK3R1,PIK3R2,MAP2K1,DGKZ,SLC44A5,SLC22A2,DGKE,SOS1,AKT3,WASL,FOS,DGKD,PLD1,WASF1,PDPK1,SLC22A3,PLA2G4C,PCYT1A,DGKQ,PIK3CB,MAPK1,WASF2,RHEB,DGKI,RAF1,SLC44A1,PDGFRB hsa01212 |Fatty acid metabolism |0.0229895113427149 |-3.77271719564326|48 |29 |0.0089866749302758 |3227 |7161 |HADHA,ACSBG2,ACADL,FADS1,HACD1,ACAA1,HACD2,PECR,ACSBG1,ACSL3,ACAT2,ACADSB,ELOVL5,TECR,CPT2,HADHB,ACADVL,ACACA,ACOX3,ACSL6,CPT1A,ACSL4,ACSL1,ACADS,HADH,ELOVL6,ACOX1,FASN,ACSL5 ko01212 |Fatty acid metabolism |0.0229895113427149 |-3.77271719564326|48 |29 |0.0089866749302758 |3227 |7161 |FASN,ACOX1,ELOVL6,ACSL5,ACSL1,ACSL4,CPT1A,HADH,ACADS,ACOX3,ACACA,ACSL6,TECR,CPT2,ACADVL,HADHB,ACAT2,ACSL3,ACADSB,ELOVL5,HACD2,PECR,ACSBG1,FADS1,ACAA1,HACD1,ACSBG2,HADHA,ACADL hsa04150 |mTOR signaling pathway |0.0244270543033032 |-3.7120639780065 |150 |80 |0.0247908273938643 |3227 |7161 |PIK3R2,PIK3R1,RPTOR,CLIP1,KRAS,PDPK1,AKT3,PIK3CB,FNIP1,EIF4B,SGK1,SLC3A2,RAF1,PRR5,ATP6V1C2,ATP6V1C1,RHEB,RPS6KA1,BRAF,LPIN1,GRB2,FZD4,FZD9,PIK3R3,RHOA,MTOR,LAMTOR4,WNT3,SEH1L,RRAGC,STRADA,AKT1S1,TTI1,RPS6KB2,PRKCA,CAB39,ATP6V1E2,DEPDC5,GSK3B,TBC1D7,MAP2K1,PRKAA1,EIF4EBP1,WNT11,EIF4E,SOS1,SESN2,RRAGB,MAPK1,SKP2,ATP6V1D,RPS6KA2,IGF1,SLC7A5,GRB10,WNT5A,SLC38A9,FZD5,RICTOR,ATP6V1G1,TNFRSF1A,FZD7,MAPKAP1,FNIP2,ATP6V1G2,NRAS,WNT7B,WNT10B,LRP5,NPRL3,TSC2,DDIT4,EIF4E2,WDR59,FZD2,IRS1,SEC13,INSR,RPS6KA3,DEPTOR ko04150 |mTOR signaling pathway |0.0244270543033032 |-3.7120639780065 |150 |80 |0.0247908273938643 |3227 |7161 |FZD7,ATP6V1G2,FNIP2,MAPKAP1,NRAS,WNT7B,FZD5,TNFRSF1A,RICTOR,ATP6V1G1,INSR,SEC13,RPS6KA3,DEPTOR,NPRL3,TSC2,WNT10B,LRP5,EIF4E2,WDR59,DDIT4,FZD2,IRS1,EIF4E,SOS1,SESN2,GSK3B,MAP2K1,TBC1D7,WNT11,PRKAA1,EIF4EBP1,RPS6KA2,SLC7A5,IGF1,GRB10,WNT5A,SLC38A9,RRAGB,MAPK1,SKP2,ATP6V1D,BRAF,LPIN1,FZD9,FZD4,GRB2,RPS6KA1,AKT1S1,TTI1,PRKCA,RPS6KB2,CAB39,DEPDC5,ATP6V1E2,LAMTOR4,MTOR,RHOA,PIK3R3,WNT3,SEH1L,RRAGC,STRADA,PDPK1,AKT3,PIK3R2,PIK3R1,CLIP1,RPTOR,KRAS,RAF1,SLC3A2,SGK1,PRR5,ATP6V1C2,RHEB,ATP6V1C1,PIK3CB,EIF4B,FNIP1 ko04261 |Adrenergic signaling in cardiomyocytes |0.0250204972674331 |-3.68805989934339|144 |77 |0.0238611713665944 |3227 |7161 |PRKCA,TPM3,PPP2R3B,PLCB1,CREB1,ADCY7,MAPK13,CACNA2D4,ADCY4,ADRA1A,KCNQ1,MYL4,PPP2R1B,PIK3R5,PPP1CC,PRKACA,CALML5,CREB5,ATP1B3,ATP2B4,ADRA1D,CACNA1D,AGTR1,ATP1A1,ATP1A2,RAPGEF4,CAMK2G,CACNB4,TPM1,CACNG6,AKT3,CACNA2D3,ADCY9,PPP2R5A,ADCY8,ADCY3,CREB3L1,SLC9A1,ATP2B3,ATP2B1,SCN5A,PPP1CB,CAMK2B,PPP1R1A,PPP2R2A,CAMK2A,PIK3CG,SCN7A,PLCB4,CALM2,CREB3L2,PPP2R2C,GNAI1,PPP2R2D,CAMK2D,ATP1B1,CALM1,GNAS,CREB3L3,CREB3L4,CACNG1,MAPK1,ATF4,ATP2A2,TPM4,CACNB3,ADCY1,BCL2,CREB3,MAPK14,PPP2CA,CREM,ATP2B2,GNAI2,CACNG4,GNAI3,FXYD2 hsa04261 |Adrenergic signaling in cardiomyocytes |0.0250204972674331 |-3.68805989934339|144 |77 |0.0238611713665944 |3227 |7161 |SCN5A,ATP2B3,ATP2B1,SLC9A1,PIK3CG,CALM2,SCN7A,PLCB4,CAMK2A,PPP2R2A,PPP1R1A,PPP1CB,CAMK2B,CREB3L2,PPP2R2C,CREB3L3,CALM1,GNAS,ATP1B1,PPP2R2D,GNAI1,CAMK2D,CREB3L4,CACNG1,CACNB3,TPM4,BCL2,ADCY1,MAPK1,ATF4,ATP2A2,CREM,PPP2CA,MAPK14,CREB3,FXYD2,GNAI2,CACNG4,GNAI3,ATP2B2,PPP2R3B,PLCB1,TPM3,PRKCA,ADRA1A,ADCY4,KCNQ1,CACNA2D4,CREB1,ADCY7,MAPK13,CREB5,PPP1CC,PIK3R5,PRKACA,CALML5,PPP2R1B,MYL4,ADRA1D,ATP1B3,ATP2B4,AGTR1,ATP1A1,CACNA1D,RAPGEF4,CAMK2G,ATP1A2,CACNA2D3,AKT3,CACNG6,TPM1,CACNB4,CREB3L1,ADCY8,ADCY3,ADCY9,PPP2R5A hsa00790 |Folate biosynthesis |0.025642850648451 |-3.6634904733729 |15 |11 |0.00340873876665634 |3227 |7161 |GCH1,SPR,FPGS,MOCS1,ALPP,DHFR,GPHN,ALPL,PTS,GGH,QDPR ko00790 |Folate biosynthesis |0.025642850648451 |-3.6634904733729 |15 |11 |0.00340873876665634 |3227 |7161 |FPGS,SPR,GCH1,GPHN,DHFR,ALPP,MOCS1,QDPR,GGH,ALPL,PTS ko00350 |Tyrosine metabolism |0.025714252990672 |-3.66070984973303|35 |22 |0.00681747753331267 |3227 |7161 |GOT1,AOX1,TAT,HPD,DCT,ADH4,HGD,ALDH3B1,ADH5,AOC3,MAOB,PNMT,GOT2,FAHD1,MIF,ADH7,DDC,ALDH1A3,ADH6,FAH,COMT,MAOA hsa00350 |Tyrosine metabolism |0.025714252990672 |-3.66070984973303|35 |22 |0.00681747753331267 |3227 |7161 |TAT,HPD,AOX1,GOT1,MAOB,PNMT,ALDH3B1,AOC3,ADH5,DCT,ADH4,HGD,MIF,FAHD1,GOT2,MAOA,COMT,ALDH1A3,FAH,ADH6,DDC,ADH7 ko05211 |Renal cell carcinoma |0.0268961322930425 |-3.6157727836396 |64 |37 |0.0114657576696622 |3227 |7161 |CDC42,CRK,PAK1,PAK3,ARNT,PIK3R3,RAPGEF1,NRAS,GRB2,ELOC,EP300,BRAF,CUL2,SLC2A1,VEGFA,RAF1,EGLN3,PAK2,PAK4,MAPK1,EGLN2,EPAS1,PIK3CB,AKT3,CRKL,SOS1,CREBBP,TGFA,KRAS,PTPN11,TGFB3,HIF1A,VHL,MAP2K1,JUN,PIK3R1,PIK3R2 ko05212 |Pancreatic cancer |0.0268961322930425 |-3.6157727836396 |64 |37 |0.0114657576696622 |3227 |7161 |IKBKG,STAT3,TGFB3,ERBB2,RALBP1,BCL2L1,KRAS,PIK3R1,CDK6,PIK3R2,MAP2K1,E2F2,AKT3,CDK4,PLD1,TGFA,PIK3CB,MAPK1,RAF1,VEGFA,SMAD4,CCND1,RALB,NFKB1,BRAF,TGFBR2,RALA,ARHGEF6,SMAD3,PIK3R3,EGF,CDC42,E2F3,CASP9,JAK1,STAT1,RALGDS hsa05212 |Pancreatic cancer |0.0268961322930425 |-3.6157727836396 |64 |37 |0.0114657576696622 |3227 |7161 |RALB,NFKB1,BRAF,TGFBR2,SMAD4,CCND1,EGF,CDC42,E2F3,CASP9,JAK1,RALGDS,STAT1,RALA,PIK3R3,SMAD3,ARHGEF6,E2F2,AKT3,PLD1,CDK4,TGFA,STAT3,TGFB3,IKBKG,BCL2L1,ERBB2,KRAS,RALBP1,CDK6,PIK3R1,PIK3R2,MAP2K1,RAF1,VEGFA,PIK3CB,MAPK1 hsa05211 |Renal cell carcinoma |0.0268961322930425 |-3.6157727836396 |64 |37 |0.0114657576696622 |3227 |7161 |TGFA,CRKL,CREBBP,SOS1,AKT3,JUN,PIK3R2,PIK3R1,MAP2K1,TGFB3,HIF1A,VHL,KRAS,PTPN11,RAF1,VEGFA,SLC2A1,EGLN2,PIK3CB,EPAS1,MAPK1,PAK4,EGLN3,PAK2,ELOC,EP300,BRAF,GRB2,NRAS,CUL2,CRK,CDC42,PIK3R3,RAPGEF1,ARNT,PAK3,PAK1 ko00340 |Histidine metabolism |0.027126963239962 |-3.60722709223052|24 |16 |0.00495816547877285 |3227 |7161 |MAOA,ALDH1A3,DDC,ALDH2,HAL,AMDHD1,CNDP2,HNMT,MAOB,ALDH3A2,ALDH3B1,CNDP1,HDC,ALDH7A1,UROC1,ALDH1B1 hsa00340 |Histidine metabolism |0.027126963239962 |-3.60722709223052|24 |16 |0.00495816547877285 |3227 |7161 |MAOA,ALDH1A3,DDC,ALDH2,AMDHD1,HAL,CNDP2,HNMT,MAOB,ALDH3A2,ALDH3B1,CNDP1,ALDH7A1,HDC,UROC1,ALDH1B1 hsa01200 |Carbon metabolism |0.0276004267105878 |-3.58992404585 |114 |62 |0.0192128912302448 |3227 |7161 |HKDC1,OGDH,SUCLG1,SUCLG2,ACSS2,DLST,PSAT1,IDH3A,GOT2,CPS1,ALDOA,GPT2,MDH2,ALDOB,GAPDH,ACO2,MDH1,RPIA,RPE,PGK1,GOT1,H6PD,CAT,IDH2,ADH5,PGLS,IDH1,MTHFR,SHMT2,ME3,PFKP,PHGDH,MCEE,ESD,GCK,AGXT,GLYCTK,ACADS,GLDC,GPI,RPEL1,ACSS1,ACO1,PFKL,HK2,RGN,HADHA,PKM,TALDO1,PGD,SDSL,PCCB,PGK2,GPT,SDHB,ME2,PSPH,CS,ADPGK,FBP1,ACAT2,IDNK ko04670 |Leukocyte transendothelial migration |0.0276004267105878 |-3.58992404585 |114 |62 |0.0192128912302448 |3227 |7161 |ACTB,CLDN19,CLDN24,CTNNA1,CXCR4,RAPGEF4,PIK3CB,CTNNA3,ARHGAP35,MMP9,CLDN4,PECAM1,ROCK2,MYL12B,ITGAM,MAPK14,ITGB1,CLDN7,ACTN4,F11R,PTPN11,ACTN1,MYL9,ACTG1,GNAI3,CLDN14,GNAI2,CLDN23,PIK3R2,CYBA,PIK3R1,RHOH,NOX1,VAV3,MMP2,CDC42,CLDN1,THY1,CLDN22,PRKCA,CD99,VAV2,NOX3,ICAM1,PLCG2,CDH5,VCL,CTNNB1,RHOA,NCF2,MAPK13,ROCK1,PIK3R3,ITGAL,PTK2,AFDN,MYL10,BCAR1,PTK2B,PXN,ITGB2,GNAI1 ko01200 |Carbon metabolism |0.0276004267105878 |-3.58992404585 |114 |62 |0.0192128912302448 |3227 |7161 |IDH2,H6PD,CAT,IDH1,MTHFR,ADH5,PGLS,RPIA,RPE,GOT1,PGK1,ALDOA,CPS1,GPT2,MDH2,ACO2,ALDOB,GAPDH,MDH1,SUCLG2,SUCLG1,HKDC1,OGDH,ACSS2,DLST,PSAT1,GOT2,IDH3A,PSPH,ADPGK,CS,FBP1,IDNK,ACAT2,RGN,HK2,PGD,PKM,TALDO1,HADHA,SDSL,ME2,PGK2,PCCB,SDHB,GPT,ACADS,RPEL1,GPI,GLDC,ACSS1,PFKL,ACO1,ME3,SHMT2,PHGDH,PFKP,AGXT,GCK,MCEE,ESD,GLYCTK hsa04670 |Leukocyte transendothelial migration |0.0276004267105878 |-3.58992404585 |114 |62 |0.0192128912302448 |3227 |7161 |PIK3R3,ROCK1,MAPK13,NCF2,RHOA,CTNNB1,VCL,CDH5,PLCG2,ICAM1,NOX3,VAV2,CD99,PRKCA,CLDN22,THY1,CLDN1,CDC42,GNAI1,ITGB2,PXN,PTK2B,BCAR1,MYL10,AFDN,ITGAL,PTK2,CTNNA3,PIK3CB,RAPGEF4,CXCR4,CLDN24,CTNNA1,CLDN19,ACTB,VAV3,NOX1,MMP2,RHOH,CLDN23,PIK3R1,CYBA,PIK3R2,GNAI2,CLDN14,GNAI3,MYL9,ACTN1,ACTG1,F11R,PTPN11,ACTN4,CLDN7,MAPK14,ITGAM,ITGB1,MYL12B,ROCK2,PECAM1,CLDN4,MMP9,ARHGAP35 hsa00620 |Pyruvate metabolism |0.0281403575151892 |-3.57055052250136|39 |24 |0.00743724821815928 |3227 |7161 |ALDH3A2,GRHPR,ACOT12,ACAT2,GLO1,ALDH7A1,PKM,LDHD,LDHA,HAGH,ALDH1B1,ME2,ACACB,MDH2,LDHAL6B,ACSS1,PCK2,MDH1,ACYP2,ALDH2,ME3,ACSS2,PCK1,ACACA ko00620 |Pyruvate metabolism |0.0281403575151892 |-3.57055052250136|39 |24 |0.00743724821815928 |3227 |7161 |ALDH3A2,ACAT2,ACOT12,GRHPR,LDHA,LDHD,PKM,GLO1,ALDH7A1,ME2,HAGH,ALDH1B1,MDH2,ACACB,PCK2,MDH1,LDHAL6B,ACSS1,ACSS2,PCK1,ACYP2,ALDH2,ME3,ACACA hsa04925 |Aldosterone synthesis and secretion |0.028475373443103 |-3.55871565496393|82 |46 |0.014254725751472 |3227 |7161 |PRKACA,CALML5,CREB3L2,CREB5,SCARB1,PRKCE,CALM1,ORAI1,GNAS,CYP11B2,CREB3L3,CAMK4,MC2R,NR4A1,CAMK2D,ITPR3,PLCB1,PRKCA,ADCY4,CAMK2A,CALM2,PLCB4,CREB1,ADCY7,CAMK2B,KCNK9,STAR,LIPE,CREB3,ADCY3,ADCY8,DAGLB,CREB3L1,ADCY9,ITPR2,CACNA1D,KCNK3,AGTR1,CREB3L4,NR4A2,ITPR1,ADCY1,ATF1,CAMK2G,LDLR,ATF4 ko04925 |Aldosterone synthesis and secretion |0.028475373443103 |-3.55871565496393|82 |46 |0.014254725751472 |3227 |7161 |ITPR3,PLCB1,PRKCA,ADCY4,CAMK2A,PLCB4,CALM2,CREB1,ADCY7,CAMK2B,KCNK9,STAR,PRKACA,CALML5,CREB3L2,CREB5,SCARB1,PRKCE,CALM1,GNAS,ORAI1,CYP11B2,CREB3L3,CAMK4,MC2R,NR4A1,CAMK2D,CACNA1D,KCNK3,CREB3L4,AGTR1,NR4A2,ITPR1,ADCY1,ATF1,CAMK2G,ATF4,LDLR,LIPE,CREB3,ADCY8,ADCY3,DAGLB,CREB3L1,ADCY9,ITPR2 hsa00360 |Phenylalanine metabolism |0.0303101632049344 |-3.49627220340253|17 |12 |0.00371862410907964 |3227 |7161 |GOT2,PAH,GOT1,MIF,TAT,HPD,DDC,ALDH1A3,ALDH3B1,AOC3,MAOB,MAOA ko00360 |Phenylalanine metabolism |0.0303101632049344 |-3.49627220340253|17 |12 |0.00371862410907964 |3227 |7161 |PAH,GOT2,GOT1,MIF,HPD,TAT,DDC,AOC3,ALDH3B1,ALDH1A3,MAOB,MAOA M00684 |JAK-STAT signaling |0.0344765682692815 |-3.36747536629299|19 |13 |0.00402850945150294 |3227 |7161 |SOCS2,SOCS3,SOCS6,CISH,STAT3,SOCS1,STAT6,STAT1,JAK1,JAK2,STAT5A,STAT5B,TYK2 hsa_M00684|JAK-STAT signaling |0.0344765682692815 |-3.36747536629299|19 |13 |0.00402850945150294 |3227 |7161 |CISH,STAT3,SOCS2,SOCS3,SOCS6,JAK2,STAT5A,STAT5B,TYK2,SOCS1,STAT6,STAT1,JAK1 hsa01522 |Endocrine resistance |0.0359430016283337 |-3.32582088335305|95 |52 |0.0161140378060118 |3227 |7161 |MMP9,AKT3,SOS1,E2F2,GPER1,MAPK14,CDK4,FOS,KRAS,ERBB2,ADCY3,ADCY8,MAP2K1,PIK3R1,PIK3R2,MMP2,ADCY9,JUN,IGF1,RAF1,SHC3,BCL2,ADCY1,MAPK1,PIK3CB,NCOA3,PTK2,JAG1,NRAS,ESR1,PRKACA,GRB2,NOTCH3,MED1,BRAF,GNAS,CCND1,CARM1,NOTCH1,E2F3,HBEGF,RPS6KB2,CDKN1A,SHC1,MDM2,ADCY4,SHC4,MAPK13,MTOR,ADCY7,SRC,PIK3R3 ko01522 |Endocrine resistance |0.0359430016283337 |-3.32582088335305|95 |52 |0.0161140378060118 |3227 |7161 |RPS6KB2,HBEGF,E2F3,ADCY7,SRC,MTOR,MAPK13,PIK3R3,SHC4,SHC1,MDM2,ADCY4,CDKN1A,BRAF,MED1,NOTCH3,GRB2,PRKACA,PTK2,JAG1,ESR1,NRAS,CARM1,NOTCH1,CCND1,GNAS,RAF1,IGF1,PIK3CB,NCOA3,MAPK1,BCL2,ADCY1,SHC3,CDK4,FOS,MAPK14,GPER1,E2F2,SOS1,MMP9,AKT3,PIK3R2,PIK3R1,MMP2,ADCY9,JUN,MAP2K1,ADCY8,ADCY3,KRAS,ERBB2 ko00010 |Glycolysis / Gluconeogenesis |0.0360322733076954 |-3.32334026135559|67 |38 |0.0117756430120855 |3227 |7161 |ACSS2,ALDH2,HKDC1,ALDOA,PCK2,ALDH1A3,LDHAL6B,GAPDH,ALDOB,AKR1A1,LDHA,PGM2,ALDH7A1,ALDH1B1,GALM,PGK1,ALDH3A2,G6PC2,BPGM,ADH5,PCK1,PFKP,PGM1,GCK,GPI,G6PC,ADH7,PFKL,ACSS1,ADH6,PKM,HK2,PGK2,ADPGK,ADH4,ALDH3B1,G6PC3,FBP1 hsa00010 |Glycolysis / Gluconeogenesis |0.0360322733076954 |-3.32334026135559|67 |38 |0.0117756430120855 |3227 |7161 |PCK1,PFKP,GCK,PGM1,G6PC,GPI,ACSS1,ADH6,PFKL,ADH7,HK2,PKM,PGK2,ADPGK,G6PC3,ALDH3B1,FBP1,ADH4,ALDH2,HKDC1,ACSS2,ALDOA,ALDH1A3,ALDOB,LDHAL6B,GAPDH,PCK2,ALDH7A1,AKR1A1,LDHA,PGM2,ALDH1B1,PGK1,GALM,ALDH3A2,BPGM,ADH5,G6PC2 ko01040 |Biosynthesis of unsaturated fatty acids |0.0414233868669631 |-3.18390965747871|23 |15 |0.00464828013634955 |3227 |7161 |HACD1,ACAA1,FADS1,ACOT2,ACOX3,TECR,HADHA,ELOVL5,BAAT,ACOT7,ACOT1,ELOVL6,ACOX1,HACD2,PECR hsa01040 |Biosynthesis of unsaturated fatty acids |0.0414233868669631 |-3.18390965747871|23 |15 |0.00464828013634955 |3227 |7161 |TECR,HADHA,FADS1,ACOT2,ACOX3,HACD1,ACAA1,HACD2,PECR,ELOVL6,ACOX1,BAAT,ELOVL5,ACOT1,ACOT7 hsa04725 |Cholinergic synapse |0.0422929728595629 |-3.16313433298187|112 |60 |0.0185931205453982 |3227 |7161 |GNGT2,GNG10,PIK3R5,PRKACA,CREB5,CREB3L2,NRAS,KCNJ2,CAMK2D,GNAI1,CAMK4,CREB3L3,GNG7,PRKCA,ITPR3,PLCB1,JAK2,GNB5,ADCY7,CAMK2B,PIK3R3,CREB1,GNB4,CAMK2A,KCNQ1,ADCY4,PLCB4,PIK3CG,ACHE,CREB3,FOS,CACNA1A,CHRM5,AKT3,PIK3R1,PIK3R2,ADCY9,MAP2K1,GNAI3,ITPR2,GNG4,GNAI2,ADCY8,ADCY3,CREB3L1,KRAS,KCNJ4,FYN,CACNA1D,KCNQ4,CHRNA6,CREB3L4,PIK3CB,ATF4,MAPK1,ITPR1,BCL2,ADCY1,KCNJ3,CAMK2G hsa04962 |Vasopressin-regulated water reabsorption |0.0426725198916208 |-3.15420012817976|44 |26 |0.00805701890300589 |3227 |7161 |DCTN4,PRKACA,DYNC1H1,CREB5,CREB3L2,CREB3,AQP3,AQP4,ADCY3,GNAS,CREB3L1,CREB3L3,DCTN1,RAB5C,VAMP2,ADCY9,DYNC2LI1,DYNC1I2,CREB3L4,ARHGDIA,RAB5B,STX4,DCTN2,RAB11A,CREB1,DYNC1LI1 ko04962 |Vasopressin-regulated water reabsorption |0.0426725198916208 |-3.15420012817976|44 |26 |0.00805701890300589 |3227 |7161 |DYNC2LI1,CREB3L4,DYNC1I2,ARHGDIA,RAB11A,RAB5B,DCTN2,STX4,DYNC1LI1,CREB1,CREB5,DYNC1H1,CREB3L2,DCTN4,PRKACA,CREB3,AQP3,CREB3L1,CREB3L3,DCTN1,AQP4,ADCY3,GNAS,VAMP2,RAB5C,ADCY9 hsa05213 |Endometrial cancer |0.0446755723715467 |-3.10832840612064|50 |29 |0.0089866749302758 |3227 |7161 |CCND1,MAP2K1,GSK3B,PIK3R1,PIK3R2,ERBB2,KRAS,TCF7,PDPK1,BRAF,AKT3,MLH1,AXIN2,NRAS,SOS1,AXIN1,GRB2,MAPK1,CTNNB1,PIK3CB,PIK3R3,CTNNA3,CDH1,CTNNA1,CASP9,RAF1,FOXO3,TCF7L2,EGF ko05213 |Endometrial cancer |0.0446755723715467 |-3.10832840612064|50 |29 |0.0089866749302758 |3227 |7161 |KRAS,ERBB2,MAP2K1,CCND1,PIK3R1,GSK3B,PIK3R2,NRAS,AKT3,MLH1,AXIN2,SOS1,AXIN1,GRB2,TCF7,PDPK1,BRAF,CDH1,CTNNB1,MAPK1,PIK3CB,CTNNA3,PIK3R3,FOXO3,TCF7L2,EGF,RAF1,CASP9,CTNNA1 ko04064 |NF-kappa B signaling pathway |0.0450257710758132 |-3.10052026256285|94 |51 |0.0158041524635885 |3227 |7161 |BCL10,XIAP,LBP,BCL2L1,ATM,BCL2A1,CCL19,IKBKG,MALT1,LTBR,TRAF3,TAB3,CSNK2A1,TRAF1,BIRC3,TRAF2,CARD11,BCL2,PARP1,NFKB2,IL1B,CD14,ERC1,CARD10,IL1R1,TNFRSF1A,LY96,DDX58,CSNK2B,TNFRSF11A,CD40,TNFSF14,NFKB1,NFKBIA,IRAK1,LYN,CXCL8,TAB2,PLCG2,MAP3K14,TAB1,ICAM1,RIPK1,BIRC2,CXCL2,UBE2I,GADD45B,BLNK,TRIM25,CFLAR,CSNK2A2 hsa04064 |NF-kappa B signaling pathway |0.0450257710758132 |-3.10052026256285|94 |51 |0.0158041524635885 |3227 |7161 |CARD10,ERC1,DDX58,LY96,IL1R1,TNFRSF1A,CD40,TNFSF14,NFKB1,TNFRSF11A,CSNK2B,IRAK1,LYN,NFKBIA,MAP3K14,TAB1,CXCL8,TAB2,PLCG2,RIPK1,CXCL2,BIRC2,ICAM1,BLNK,GADD45B,UBE2I,CSNK2A2,TRIM25,CFLAR,BCL10,XIAP,LBP,IKBKG,CCL19,BCL2A1,BCL2L1,ATM,MALT1,LTBR,TRAF3,TAB3,CSNK2A1,BCL2,CARD11,TRAF1,BIRC3,TRAF2,IL1B,PARP1,NFKB2,CD14 hsa04912 |GnRH signaling pathway |0.0452821360271967 |-3.09484267245435|92 |50 |0.0154942671211652 |3227 |7161 |CALML5,PRKACA,GRB2,NRAS,PTK2B,PRKCD,GNAS,CALM1,MAP2K6,CAMK2D,MAP2K7,PLA2G4E,ITPR3,PLCB1,CDC42,MMP14,HBEGF,PRKCA,CAMK2A,ADCY4,GNRH1,PLCB4,CALM2,ADCY7,MAPK13,SRC,CAMK2B,SOS1,PLD1,MAP3K3,MAPK14,ADCY8,ADCY3,KRAS,ADCY9,MMP2,JUN,MAP2K1,ITPR2,CACNA1D,MAP3K1,MAP2K3,RAF1,MAP3K4,ITPR1,ADCY1,CAMK2G,PLA2G4C,ATF4,MAPK1 ko04912 |GnRH signaling pathway |0.0452821360271967 |-3.09484267245435|92 |50 |0.0154942671211652 |3227 |7161 |MAP2K6,CALM1,GNAS,PLA2G4E,CAMK2D,MAP2K7,NRAS,GRB2,PRKACA,CALML5,PRKCD,PTK2B,PLCB4,CALM2,GNRH1,ADCY4,CAMK2A,CAMK2B,SRC,MAPK13,ADCY7,CDC42,HBEGF,MMP14,PLCB1,ITPR3,PRKCA,KRAS,ADCY8,ADCY3,ITPR2,MAP2K1,JUN,ADCY9,MMP2,SOS1,MAPK14,MAP3K3,PLD1,PLA2G4C,CAMK2G,ADCY1,ITPR1,MAPK1,ATF4,MAP2K3,MAP3K1,CACNA1D,MAP3K4,RAF1 hsa04137 |Mitophagy - animal |0.046768624440824 |-3.06254271882024|64 |36 |0.0111558723272389 |3227 |7161 |RRAS2,AMBRA1,TBK1,BECN2,CSNK2A1,ATF4,TFE3,RHOT2,MFN2,GABARAPL1,TAX1BP1,BNIP3L,JUN,BCL2L1,KRAS,HIF1A,CITED2,SQSTM1,ATG5,CALCOCO2,RAB7A,FOXO3,CSNK2A2,SRC,UBB,GABARAPL2,TFEB,CSNK2B,NRAS,BNIP3,MRAS,NBR1,USP15,PINK1,EIF2AK3,PGAM5 ko04137 |Mitophagy - animal |0.046768624440824 |-3.06254271882024|64 |36 |0.0111558723272389 |3227 |7161 |RAB7A,CALCOCO2,ATG5,CSNK2A2,FOXO3,SRC,TFEB,GABARAPL2,UBB,CSNK2B,NBR1,MRAS,NRAS,BNIP3,PINK1,USP15,PGAM5,EIF2AK3,AMBRA1,RRAS2,TBK1,TFE3,CSNK2A1,ATF4,BECN2,GABARAPL1,MFN2,RHOT2,TAX1BP1,JUN,BNIP3L,CITED2,SQSTM1,HIF1A,BCL2L1,KRAS hsa_M00695|cAMP signaling |0.0489616117161517 |-3.01671872228084|16 |11 |0.00340873876665634 |3227 |7161 |ADCY4,GNAS,ADCY1,ADCY8,ADCY3,GNAI2,GNAI3,ADCY9,GNAI1,ADCY7,PRKACA M00295 |BRCA1-associated genome surveillance complex (BASC) |0.0489616117161517 |-3.01671872228084|16 |11 |0.00340873876665634 |3227 |7161 |MSH6,BRCA1,NBN,MSH2,RFC2,ATM,RFC1,RFC3,PMS2,MLH1,PCNA hsa_M00099|Sphingosine biosynthesis |0.0489616117161517 |-3.01671872228084|16 |11 |0.00340873876665634 |3227 |7161 |ACER2,ACER1,CERS2,CERS4,SPTLC2,ASAH2,DEGS1,KDSR,DEGS2,CERS6,SPTLC3 M00099 |Sphingosine biosynthesis |0.0489616117161517 |-3.01671872228084|16 |11 |0.00340873876665634 |3227 |7161 |ACER2,ACER1,CERS2,CERS4,SPTLC2,ASAH2,DEGS1,KDSR,DEGS2,SPTLC3,CERS6 hsa_M00295|BRCA1-associated genome surveillance complex (BASC) |0.0489616117161517 |-3.01671872228084|16 |11 |0.00340873876665634 |3227 |7161 |MSH2,RFC2,ATM,MSH6,NBN,BRCA1,PCNA,PMS2,MLH1,RFC1,RFC3 M00695 |cAMP signaling |0.0489616117161517 |-3.01671872228084|16 |11 |0.00340873876665634 |3227 |7161 |PRKACA,ADCY7,GNAI1,ADCY9,GNAI3,GNAI2,ADCY1,ADCY8,ADCY3,GNAS,ADCY4 hsa04921 |Oxytocin signaling pathway |0.0499460165363663 |-2.99681252608939|152 |79 |0.024480942051441 |3227 |7161 |CACNG1,KCNJ4,RGS2,MYLK3,EEF2,CACNB3,ITPR1,ADCY1,MAPK1,PPP1R12B,ROCK2,TRPM2,PRKAA1,ACTG1,MYL9,PPP3CA,JUN,GNAI2,ITPR2,CACNG4,MAP2K1,GNAI3,MYLK,CAMK2A,PIK3CG,PLCB4,CALM2,ROCK1,PPP1CB,CAMK2B,SRC,MYL6,NRAS,CALM1,GNAS,CD38,CAMK4,PLA2G4E,GNAI1,CAMK2D,CACNA1D,ACTB,MYLK4,RAF1,KCNJ3,EEF2K,PLA2G4C,CAMK2G,NFATC3,CACNA2D3,FOS,CACNB4,CACNG6,OXT,ADCY8,ADCY3,KRAS,ADCY9,ITPR3,PRKAB1,PLCB1,PRKCA,ADCY4,CDKN1A,PRKAB2,NFATC2,ADCY7,RHOA,PRKAG2,CACNA2D4,PIK3R5,PRKACA,PPP1CC,CALML5,KCNJ2,PRKAG1,RCAN1,MYL6B,CCND1 ko04921 |Oxytocin signaling pathway |0.0499460165363663 |-2.99681252608939|152 |79 |0.024480942051441 |3227 |7161 |MYLK,PIK3CG,PLCB4,CALM2,CAMK2A,ROCK1,PPP1CB,CAMK2B,SRC,NRAS,MYL6,CAMK4,CD38,CALM1,GNAS,PLA2G4E,GNAI1,CAMK2D,CACNG1,EEF2,KCNJ4,RGS2,MYLK3,CACNB3,ADCY1,ITPR1,MAPK1,PPP1R12B,ROCK2,TRPM2,PPP3CA,ACTG1,PRKAA1,MYL9,GNAI2,ITPR2,GNAI3,CACNG4,MAP2K1,JUN,PRKAB1,PLCB1,ITPR3,PRKCA,CDKN1A,ADCY4,PRKAG2,CACNA2D4,PRKAB2,NFATC2,ADCY7,RHOA,KCNJ2,PRKACA,PPP1CC,PIK3R5,CALML5,PRKAG1,RCAN1,CCND1,MYL6B,MYLK4,CACNA1D,ACTB,RAF1,PLA2G4C,CAMK2G,KCNJ3,EEF2K,NFATC3,CACNA2D3,CACNG6,FOS,CACNB4,KRAS,OXT,ADCY3,ADCY8,ADCY9 ko00052 |Galactose metabolism |0.0508987298430104 |-2.97791730970538|31 |19 |0.00588782150604276 |3227 |7161 |MGAM2,GANC,GALM,HK2,PGM2,G6PC3,G6PC2,GLB1,B4GALT2,GCK,UGP2,GALE,PGM1,AKR1B1,HKDC1,PFKP,PFKL,G6PC,GALT hsa00052 |Galactose metabolism |0.0508987298430104 |-2.97791730970538|31 |19 |0.00588782150604276 |3227 |7161 |GANC,GALM,MGAM2,PGM2,HK2,G6PC2,G6PC3,GLB1,PGM1,GALE,UGP2,B4GALT2,GCK,PFKP,AKR1B1,HKDC1,PFKL,GALT,G6PC ko00250 |Alanine, aspartate and glutamate metabolism |0.0540037092527948 |-2.91870254491033|35 |21 |0.00650759219088937 |3227 |7161 |GPT2,GLS,CPS1,ASNS,ABAT,ALDH5A1,GOT2,NIT2,AGXT,ASS1,ADSSL1,ADSS,GFPT2,GLS2,ASL,ALDH4A1,AGXT2,GFPT1,RIMKLB,GPT,GOT1 hsa00250 |Alanine, aspartate and glutamate metabolism |0.0540037092527948 |-2.91870254491033|35 |21 |0.00650759219088937 |3227 |7161 |GFPT2,GLS2,ASL,ADSS,ADSSL1,GOT1,GPT,GFPT1,RIMKLB,AGXT2,ALDH4A1,ASNS,GLS,CPS1,GPT2,AGXT,ASS1,NIT2,GOT2,ABAT,ALDH5A1 ko04916 |Melanogenesis |0.0542046619170823 |-2.91498836100516|101 |54 |0.0167338084908584 |3227 |7161 |CREB3L3,CALM1,GNAS,FZD5,GNAI1,CAMK2D,WNT7B,CREB3L2,NRAS,PRKACA,CALML5,FZD9,FZD4,KIT,POMC,TCF7,FZD7,EP300,PLCB4,CALM2,ADCY4,CAMK2A,FZD2,CTNNB1,WNT3,WNT10B,CREB1,CAMK2B,ADCY7,MC1R,EDN1,PLCB1,TCF7L2,PRKCA,KRAS,CREB3L1,DCT,ADCY3,ADCY8,WNT11,GNAI2,MAP2K1,GNAI3,ADCY9,GSK3B,KITLG,CREBBP,CREB3,CAMK2G,ADCY1,MAPK1,CREB3L4,WNT5A,RAF1 hsa04916 |Melanogenesis |0.0542046619170823 |-2.91498836100516|101 |54 |0.0167338084908584 |3227 |7161 |DCT,ADCY8,WNT11,ADCY3,KRAS,CREB3L1,ADCY9,GSK3B,GNAI2,MAP2K1,GNAI3,CREBBP,KITLG,CREB3,ADCY1,CAMK2G,MAPK1,CREB3L4,WNT5A,RAF1,CALM1,GNAS,CREB3L3,FZD5,GNAI1,CAMK2D,PRKACA,FZD4,FZD9,CALML5,KIT,NRAS,WNT7B,CREB3L2,EP300,FZD7,POMC,TCF7,ADCY4,CAMK2A,FZD2,CALM2,PLCB4,WNT10B,CREB1,ADCY7,CAMK2B,CTNNB1,WNT3,TCF7L2,MC1R,EDN1,PLCB1,PRKCA hsa04933 |AGE-RAGE signaling pathway in diabetic complications |0.0546611641688757 |-2.90660180033954|99 |53 |0.0164239231484351 |3227 |7161 |CXCL8,PLCG2,SMAD3,PIK3R3,MAPK13,ICAM1,PLCB4,NOX3,SELE,STAT1,SERPINE1,DIAPH1,PRKCA,CDC42,EDN1,JAK2,PLCB1,VEGFD,CCND1,SMAD4,TGFBR2,PRKCE,PRKCD,COL4A4,NFKB1,STAT5A,NRAS,STAT5B,MAPK1,EGR1,COL4A5,PIK3CB,BCL2,VEGFA,IL1B,AGTR1,AGER,JUN,NOX1,MMP2,PIK3R1,PIK3R2,PRKCZ,PIM1,KRAS,TGFB3,STAT3,MAPK14,FN1,CDK4,AKT3,PLCD3,IL1A ko04933 |AGE-RAGE signaling pathway in diabetic complications |0.0546611641688757 |-2.90660180033954|99 |53 |0.0164239231484351 |3227 |7161 |STAT3,TGFB3,KRAS,PIM1,PIK3R1,PIK3R2,PRKCZ,NOX1,JUN,MMP2,IL1A,AKT3,PLCD3,CDK4,FN1,MAPK14,BCL2,PIK3CB,COL4A5,MAPK1,EGR1,AGER,AGTR1,IL1B,VEGFA,SMAD4,CCND1,STAT5B,NRAS,STAT5A,NFKB1,COL4A4,PRKCD,PRKCE,TGFBR2,SELE,NOX3,PLCB4,ICAM1,MAPK13,PIK3R3,SMAD3,PLCG2,CXCL8,VEGFD,JAK2,PLCB1,EDN1,CDC42,DIAPH1,PRKCA,SERPINE1,STAT1 hsa04144 |Endocytosis |0.0589053733856367 |-2.83182296352753|260 |130 |0.0402850945150294 |3227 |7161 |CDC42,GIT2,CYTH1,RAB7A,VPS4B,PDCD6IP,STAM,CHMP4B,RAB5B,BIN1,CHMP4A,TFRC,SNX12,RAB11FIP4,SH3KBP1,SMAP2,CSF1R,RAB22A,ARF1,ARPC5,CYTH3,LDLRAP1,FOLR1,CHMP6,PARD3,EHD1,CHMP2B,GRK3,EPS15,CXCR1,RNF41,IGF2R,PSD,WASL,PLD1,FGFR3,VPS37B,RAB11FIP1,CAPZA2,PDGFRA,RAB4A,CHMP4C,RUFY1,AGAP1,EEA1,AP2B1,EPS15L1,MDM2,SH3GL1,SMAD3,RHOA,RAB11FIP3,AP2A1,TGFBR2,ARFGAP1,ITCH,ARPC2,AP2M1,RAB31,CHMP2A,SNX2,ZFYVE16,PARD6G,AGAP3,AP2A2,PRKCI,ARAP2,TGFB3,ARFGAP3,PSD3,EGF,EPN3,PIP5K1B,FGFR2,ARFGEF2,ARRB1,SMURF1,SRC,SMURF2,ARPC1B,SNX5,ASAP1,ERBB3,DAB2,WWP1,HSPA1B,ARAP3,CBLB,PARD6B,CAV1,RAB11FIP2,RNF103-CHMP3,ARF6,HSPA1A,FGFR4,NEDD4,PRKCZ,RAB5C,IQSEC1,CHMP3,SH3GLB1,NEDD4L,MVB12B,ASAP2,HSPA6,PSD2,WASHC5,KIT,ASAP3,RAB35,ARPC1A,ARFGAP2,KIF5B,CAPZB,PIP5K1A,EHD2,VPS45,DNM2,IST1,RAB11A,CXCR4,HSPA8,RAB10,AP2S1,LDLR,ARAP1,GRK5,ARPC5L,CHMP1B,VPS4A ko04144 |Endocytosis |0.0589053733856367 |-2.83182296352753|260 |130 |0.0402850945150294 |3227 |7161 |AGAP1,RUFY1,CHMP4C,PDGFRA,RAB4A,RHOA,SH3GL1,SMAD3,MDM2,EPS15L1,EEA1,AP2B1,ARFGAP1,TGFBR2,AP2A1,RAB11FIP3,RAB31,AP2M1,ITCH,ARPC2,CHMP2A,AGAP3,ZFYVE16,SNX2,PARD6G,PRKCI,AP2A2,PSD3,ARAP2,TGFB3,ARFGAP3,CYTH1,STAM,VPS4B,RAB7A,PDCD6IP,GIT2,CDC42,CHMP4A,CHMP4B,RAB5B,BIN1,RAB11FIP4,SH3KBP1,SMAP2,TFRC,SNX12,ARPC5,CYTH3,LDLRAP1,CSF1R,ARF1,RAB22A,FOLR1,CHMP2B,GRK3,EHD1,PARD3,CHMP6,IGF2R,PLD1,WASL,PSD,CXCR1,RNF41,EPS15,CAPZA2,RAB11FIP1,FGFR3,VPS37B,CHMP3,NEDD4L,SH3GLB1,IQSEC1,HSPA6,ASAP2,MVB12B,PSD2,RAB35,KIT,WASHC5,ASAP3,EHD2,KIF5B,ARPC1A,ARFGAP2,PIP5K1A,CAPZB,IST1,DNM2,VPS45,LDLR,AP2S1,RAB10,CXCR4,RAB11A,HSPA8,ARAP1,GRK5,CHMP1B,VPS4A,ARPC5L,PIP5K1B,ARFGEF2,FGFR2,EPN3,EGF,SMURF1,SRC,ARRB1,ARPC1B,SMURF2,ASAP1,SNX5,WWP1,HSPA1B,DAB2,ERBB3,CBLB,PARD6B,ARAP3,ARF6,RNF103-CHMP3,CAV1,RAB11FIP2,PRKCZ,RAB5C,NEDD4,FGFR4,HSPA1A hsa01524 |Platinum drug resistance |0.0595685152719953 |-2.82062811174154|73 |40 |0.0123954136969321 |3227 |7161 |GSTO2,MSH6,MSH2,GSTP1,PIK3R3,GSTO1,BIRC2,CASP8,MDM2,BBC3,BRCA1,GSTA1,CDKN1A,ATP7B,CASP9,MGST1,GSTA3,MAP3K5,PIK3R2,PIK3R1,MGST3,MGST2,ABCC2,XIAP,XPA,BCL2L1,ERBB2,ATM,FAS,PDPK1,FASLG,AKT3,MLH1,PIK3CB,CYCS,SLC31A1,MAPK1,BCL2,TOP2B,BIRC3 ko01524 |Platinum drug resistance |0.0595685152719953 |-2.82062811174154|73 |40 |0.0123954136969321 |3227 |7161 |MGST1,CASP9,GSTA3,PIK3R3,GSTO1,ATP7B,GSTA1,CDKN1A,BRCA1,CASP8,BIRC2,BBC3,MDM2,GSTP1,MSH2,MSH6,GSTO2,MAPK1,SLC31A1,CYCS,PIK3CB,BIRC3,TOP2B,BCL2,PDPK1,FAS,MLH1,AKT3,FASLG,XIAP,XPA,ABCC2,MGST2,MGST3,MAP3K5,PIK3R1,PIK3R2,ATM,BCL2L1,ERBB2 ko05230 |Central carbon metabolism in cancer |0.060345951216716 |-2.80766142206168|65 |36 |0.0111558723272389 |3227 |7161 |AKT3,HK2,PKM,ERBB2,KRAS,FGFR3,HIF1A,GLS2,MAP2K1,PIK3R1,PIK3R2,SLC2A2,GCK,SLC7A5,SLC2A1,PDGFRB,PFKP,RAF1,PDK1,PFKL,MAPK1,PIK3CB,NRAS,FGFR1,KIT,LDHA,IDH1,SLC16A3,PDGFRA,HKDC1,FGFR2,SLC1A5,NTRK3,GLS,PIK3R3,MTOR hsa05230 |Central carbon metabolism in cancer |0.060345951216716 |-2.80766142206168|65 |36 |0.0111558723272389 |3227 |7161 |HK2,PKM,AKT3,MAP2K1,PIK3R2,PIK3R1,KRAS,ERBB2,FGFR3,HIF1A,GLS2,PDGFRB,SLC2A1,PFKP,RAF1,SLC2A2,GCK,SLC7A5,MAPK1,PIK3CB,PDK1,PFKL,LDHA,NRAS,FGFR1,KIT,IDH1,SLC16A3,HKDC1,FGFR2,SLC1A5,PDGFRA,GLS,PIK3R3,MTOR,NTRK3 ko04071 |Sphingolipid signaling pathway |0.060514960481393 |-2.80486466382999|118 |62 |0.0192128912302448 |3227 |7161 |PPP2R2D,GNAI1,TNFRSF1A,NFKB1,S1PR2,PPP2R1B,PRKCE,CTSD,NRAS,PPP2R2C,ROCK1,PIK3R3,ACER2,MAPK13,RHOA,SGMS1,GNA12,CERS2,PPP2R2A,PLCB4,PRKCA,DEGS2,ABCC1,SPTLC3,PLCB1,PPP2R3B,PIK3R1,PRKCZ,PIK3R2,PPP2R5A,MAP3K5,BDKRB2,GNAI2,SPHK2,ACER1,MAP2K1,GNAI3,KRAS,SPTLC2,ASAH2,CERS4,DEGS1,ADORA3,PLD1,MAPK14,PDPK1,SPHK1,PPP2CA,ROCK2,AKT3,CERS6,SMPD1,SGPL1,PIK3CB,MAPK1,SGPP1,BCL2,TRAF2,RAF1,FYN,SGMS2,GAB2 hsa04071 |Sphingolipid signaling pathway |0.060514960481393 |-2.80486466382999|118 |62 |0.0192128912302448 |3227 |7161 |PRKCE,PPP2R1B,S1PR2,NFKB1,NRAS,PPP2R2C,CTSD,GNAI1,PPP2R2D,TNFRSF1A,PRKCA,SPTLC3,PPP2R3B,PLCB1,ABCC1,DEGS2,SGMS1,GNA12,MAPK13,RHOA,PIK3R3,ACER2,ROCK1,PLCB4,PPP2R2A,CERS2,SPHK1,PDPK1,MAPK14,ADORA3,PLD1,DEGS1,CERS6,AKT3,PPP2CA,ROCK2,ACER1,GNAI3,SPHK2,MAP2K1,GNAI2,MAP3K5,PRKCZ,PPP2R5A,BDKRB2,PIK3R2,PIK3R1,ASAH2,SPTLC2,CERS4,KRAS,SGMS2,FYN,RAF1,GAB2,SGPP1,MAPK1,PIK3CB,SMPD1,SGPL1,TRAF2,BCL2 hsa05202 |Transcriptional misregulation in cancer |0.0675451004274846 |-2.69495974973823|179 |91 |0.0281995661605206 |3227 |7161 |PBX1,KMT2A,DUSP6,AFF1,SPI1,PBX3,HDAC2,TCF3,ASPSCR1,HIST1H3C,WT1,ELANE,MYCN,MLLT1,CSF1R,CEBPA,CCR7,H3F3C,PDGFA,NFKB1,JMJD1C,ATF1,BIRC3,GRIA3,FUS,ETV4,GOLPH3,RUNX2,IGF1,SMAD1,ZEB1,SLC45A3,HIST1H3J,RXRA,BCL6,PAX8,IGFBP3,BCL2L1,ATM,MAF,ETV6,RUNX1,CCNT2,CDK14,MMP9,ZBTB17,ELK4,ITGAM,LDB1,RXRB,MDM2,CDKN1A,ERG,PTCRA,NSD2,RARA,CXCL8,ZBTB16,SIN3A,KDM6A,PROM1,ETV5,TMPRSS2,DDX5,PTK2,CD40,TGFBR2,TAF15,TRAF1,TFE3,MEIS1,ID2,PAX7,IL3,PER2,LYL1,NFKBIZ,HHEX,TSPAN7,CD14,PPARG,KLF3,DDIT3,IL1R2,NUPR1,CEBPE,BCL2A1,JUP,ETV7,REL,CEBPB ko05202 |Transcriptional misregulation in cancer |0.0675451004274846 |-2.69495974973823|179 |91 |0.0281995661605206 |3227 |7161 |GOLPH3,RUNX2,FUS,ETV4,ATF1,GRIA3,BIRC3,JMJD1C,PAX8,ZEB1,SLC45A3,RXRA,HIST1H3J,BCL6,SMAD1,IGF1,RUNX1,MAF,ETV6,BCL2L1,ATM,IGFBP3,ITGAM,ZBTB17,ELK4,CDK14,MMP9,CCNT2,AFF1,DUSP6,KMT2A,PBX1,PBX3,HDAC2,SPI1,CCR7,MYCN,WT1,MLLT1,ELANE,CSF1R,CEBPA,TCF3,ASPSCR1,HIST1H3C,NFKB1,H3F3C,PDGFA,ID2,TFE3,MEIS1,TRAF1,KLF3,DDIT3,HHEX,TSPAN7,PPARG,CD14,PER2,PAX7,IL3,NFKBIZ,LYL1,ETV7,JUP,IL1R2,CEBPE,BCL2A1,NUPR1,CEBPB,REL,NSD2,CXCL8,RARA,ERG,PTCRA,CDKN1A,RXRB,LDB1,MDM2,ZBTB16,DDX5,ETV5,TMPRSS2,PROM1,KDM6A,SIN3A,TAF15,TGFBR2,CD40,PTK2 ko04510 |Focal adhesion |0.0686130617340401 |-2.67927235808859|198 |100 |0.0309885342423303 |3227 |7161 |CRK,MYLK,THBS2,DIAPH1,SPP1,EGF,VEGFD,RASGRF1,CDC42,ROCK1,PPP1CB,SRC,PAK1,LAMA3,VAV2,PDGFA,COMP,COL9A2,ITGA2,TNN,PXN,MYLK3,FYN,PDGFRB,IGF1,ITGB3,MAPK1,COL4A5,PPP1R12B,BCL2,BIRC3,PAK2,ACTN4,ITGB1,FN1,ROCK2,SOS1,LAMB3,CAV1,VAV3,JUN,GSK3B,RELN,MAP2K1,VWF,ACTG1,MYL9,CCND3,PRKCA,LAMA5,ITGA7,PDGFRA,PIK3R3,PDGFC,LAMB1,RHOA,RAPGEF1,CTNNB1,PAK3,SHC4,VCL,THBS1,BIRC2,ITGA1,SHC1,COL4A4,BRAF,PPP1CC,GRB2,BCAR1,MYL10,ITGA6,LAMC1,PTK2,CCND1,CAPN2,RAF1,VEGFA,ACTB,DOCK1,MYLK4,FLNB,VTN,ITGB5,PIK3CB,PAK4,SHC3,PDPK1,MYL12B,CRKL,LAMB4,AKT3,COL9A3,COL6A3,ARHGAP35,PIK3R1,PIK3R2,XIAP,ACTN1,ERBB2 hsa04510 |Focal adhesion |0.0686130617340401 |-2.67927235808859|198 |100 |0.0309885342423303 |3227 |7161 |BIRC3,PAK2,BCL2,MAPK1,PPP1R12B,COL4A5,ITGB3,IGF1,FYN,PDGFRB,MYLK3,MYL9,ACTG1,CCND3,RELN,VWF,MAP2K1,JUN,VAV3,GSK3B,CAV1,ROCK2,LAMB3,SOS1,ITGB1,FN1,ACTN4,LAMA3,VAV2,PAK1,ROCK1,PPP1CB,SRC,CDC42,EGF,SPP1,VEGFD,RASGRF1,THBS2,DIAPH1,MYLK,CRK,TNN,PXN,ITGA2,COL9A2,COMP,PDGFA,SHC3,PAK4,ITGB5,PIK3CB,MYLK4,FLNB,VTN,ACTB,DOCK1,VEGFA,RAF1,ERBB2,ACTN1,XIAP,PIK3R2,PIK3R1,AKT3,ARHGAP35,COL9A3,COL6A3,LAMB4,CRKL,PDPK1,MYL12B,THBS1,ITGA1,BIRC2,SHC1,VCL,PAK3,CTNNB1,SHC4,PIK3R3,PDGFC,LAMB1,RAPGEF1,RHOA,ITGA7,LAMA5,PDGFRA,PRKCA,CAPN2,CCND1,LAMC1,ITGA6,PTK2,GRB2,PPP1CC,BCAR1,MYL10,COL4A4,BRAF hsa00630 |Glyoxylate and dicarboxylate metabolism |0.0700868097336101 |-2.65802066621847|28 |17 |0.00526805082119616 |3227 |7161 |MDH2,GLDC,MDH1,ACO1,ACO2,SHMT2,GLYCTK,AGXT,MCEE,CS,CAT,ACAT2,GRHPR,GCSH,HOGA1,AFMID,PCCB ko00630 |Glyoxylate and dicarboxylate metabolism |0.0700868097336101 |-2.65802066621847|28 |17 |0.00526805082119616 |3227 |7161 |ACAT2,GRHPR,GCSH,CS,CAT,PCCB,HOGA1,AFMID,MDH1,ACO1,ACO2,MDH2,GLDC,GLYCTK,AGXT,MCEE,SHMT2 hsa04611 |Platelet activation |0.070343144514794 |-2.65436994843176|123 |64 |0.0198326619150914 |3227 |7161 |ARHGEF12,TBXAS1,ITGA2,PLA2G4E,GNAI1,GNAS,MYLK,PLCG2,PPP1CB,ROCK1,SRC,PIK3CG,FGG,PLCB4,GP1BA,MAPK14,ITGB1,TBXA2R,VAMP8,ROCK2,F2RL3,GNAI2,ITPR2,GNAI3,VWF,PRKCZ,RASGRP2,ACTG1,FYN,MYLK3,ITGB3,MAPK1,ADCY1,ITPR1,PPP1CC,PRKACA,PIK3R5,LYN,ORAI1,PLCB1,ITPR3,FCGR2A,ARHGEF1,FGA,PIK3R3,RHOA,MAPK13,ADCY7,ADCY4,MYL12B,PRKCI,AKT3,ARHGAP35,FGB,ADCY9,PIK3R1,PIK3R2,ADCY8,ADCY3,MYLK4,FERMT3,ACTB,PIK3CB,PLA2G4C ko00030 |Pentose phosphate pathway |0.0719374356888878 |-2.63195848648636|30 |18 |0.00557793616361946 |3227 |7161 |PGM1,GLYCTK,PFKP,ALDOB,PFKL,ALDOA,GPI,RPEL1,RPE,RGN,RPIA,PGD,TALDO1,PGM2,FBP1,PGLS,IDNK,H6PD hsa00030 |Pentose phosphate pathway |0.0719374356888878 |-2.63195848648636|30 |18 |0.00557793616361946 |3227 |7161 |PFKP,GLYCTK,PGM1,ALDOA,GPI,RPEL1,ALDOB,PFKL,RGN,RPIA,PGM2,PGD,TALDO1,RPE,H6PD,PGLS,FBP1,IDNK hsa05145 |Toxoplasmosis |0.0746401647862024 |-2.59507651469894|113 |59 |0.0182832352029749 |3227 |7161 |HSPA1B,MAP2K3,MAPK1,LDLR,CYCS,BIRC3,CIITA,BCL2,HSPA8,PDPK1,ITGB1,MAPK14,IFNGR1,AKT3,HLA-DPA1,HLA-DMB,LAMB4,LAMB3,XIAP,GNAI2,GNAI3,BCL2L1,TGFB3,IKBKG,STAT3,HSPA1A,STAT1,SOCS1,JAK1,CASP9,LAMA5,JAK2,TYK2,TAB2,PPIF,MAPK13,LAMB1,HSPA6,IL12A,TAB1,PIK3CG,LAMA3,CASP8,BIRC2,HLA-DOB,CD40,NFKB1,NFKBIB,LAMC1,NFKBIA,ITGA6,IFNGR2,IRAK1,PIK3R5,GNAI1,IL10RB,TNFRSF1A,MAP2K6,LY96 ko05145 |Toxoplasmosis |0.0746401647862024 |-2.59507651469894|113 |59 |0.0182832352029749 |3227 |7161 |IRAK1,PIK3R5,ITGA6,NFKBIA,LAMC1,IFNGR2,CD40,NFKBIB,NFKB1,LY96,IL10RB,MAP2K6,TNFRSF1A,GNAI1,TYK2,LAMA5,JAK2,JAK1,CASP9,STAT1,SOCS1,BIRC2,CASP8,HLA-DOB,PIK3CG,LAMA3,PPIF,LAMB1,IL12A,HSPA6,MAPK13,TAB1,TAB2,LAMB4,LAMB3,HLA-DPA1,AKT3,HLA-DMB,IFNGR1,PDPK1,ITGB1,MAPK14,IKBKG,TGFB3,STAT3,HSPA1A,BCL2L1,GNAI2,XIAP,GNAI3,MAP2K3,HSPA1B,CIITA,BCL2,HSPA8,BIRC3,CYCS,MAPK1,LDLR hsa04022 |cGMP-PKG signaling pathway |0.0751212517388695 |-2.58865178103047|163 |83 |0.0257204834211342 |3227 |7161 |ADORA3,AKT3,NFATC3,ADCY9,BDKRB2,SRF,VDAC1,ADCY3,ADCY8,CREB3L1,RAF1,CACNA1D,MYLK4,AGTR1,ADRA2A,ATP1A1,ATP1A2,MEF2B,ATP2A1,PRKCE,PPP1CC,ADRA2C,PIK3R5,CALML5,CREB5,GTF2I,ATP1B3,ATP2B4,ADRA1D,SLC8A3,VDAC3,ITPR3,KCNMA1,PLCB1,CREB1,PPIF,RHOA,ADCY7,NFATC2,ADRA1A,ADCY4,CREB3,ROCK2,PDE3B,SLC25A4,ATP2B2,MRVI1,GNAI2,ITPR2,MAP2K1,GNAI3,FXYD2,MYL9,GATA4,PPP3CA,GTF2IRD1,RGS2,MYLK3,CREB3L4,MAPK1,ATP2A2,ATF4,ADCY1,ITPR1,CREB3L2,GNAI1,ATP1B1,CALM1,CREB3L3,MYLK,INSR,CNGB1,ATP2B3,ATP2B1,PPP1CB,ROCK1,MEF2A,GNA12,VDAC2,IRS1,PIK3CG,PLCB4,CALM2 ko04022 |cGMP-PKG signaling pathway |0.0751212517388695 |-2.58865178103047|163 |83 |0.0257204834211342 |3227 |7161 |GATA4,FXYD2,MYL9,PPP3CA,MRVI1,ATP2B2,GNAI3,MAP2K1,ITPR2,GNAI2,PDE3B,ROCK2,SLC25A4,CREB3,ADCY1,ITPR1,ATP2A2,ATF4,MAPK1,CREB3L4,MYLK3,RGS2,GTF2IRD1,CALM1,CREB3L3,GNAI1,ATP1B1,CREB3L2,PLCB4,CALM2,VDAC2,IRS1,PIK3CG,PPP1CB,ROCK1,MEF2A,GNA12,INSR,MYLK,ATP2B1,CNGB1,ATP2B3,ADCY3,ADCY8,VDAC1,CREB3L1,BDKRB2,ADCY9,SRF,AKT3,NFATC3,ADORA3,ATP2A1,ATP1A2,MEF2B,CACNA1D,ADRA2A,ATP1A1,MYLK4,AGTR1,RAF1,ADRA1D,ATP1B3,ATP2B4,GTF2I,CALML5,ADRA2C,PIK3R5,PPP1CC,CREB5,PRKCE,ADRA1A,ADCY4,NFATC2,ADCY7,RHOA,CREB1,PPIF,ITPR3,PLCB1,KCNMA1,VDAC3,SLC8A3 ko04062 |Chemokine signaling pathway |0.0764357398313813 |-2.57130489335336|182 |92 |0.0285094515029439 |3227 |7161 |GSK3A,JAK2,PLCB1,STAT1,GNG7,CCR8,ADCY4,SHC1,SHC4,CXCL8,GNB4,PIK3R3,ADCY7,RHOA,NFKBIA,PTK2,BCAR1,PRKACA,GRB2,LYN,NFKBIB,BRAF,GNGT2,PREX1,RAF1,SHC3,CXCL11,CXCR4,PIK3CB,AKT3,CXCR5,CRKL,CCL17,GRK5,KRAS,STAT3,ADCY3,ADCY8,GNG4,ADCY9,ELMO1,PIK3R1,PIK3R2,FOXO3,CDC42,FGR,CRK,CCL3L3,CCR6,PLCB4,VAV2,ARRB1,PAK1,CXCL2,CXCL5,CCL25,ROCK1,SRC,GNB5,NRAS,STAT5B,PRKCD,CCL28,PTK2B,NFKB1,GNG10,PXN,CCL16,CX3CL1,CCR7,GNAI1,PARD3,ADCY1,CCL20,MAPK1,CCR1,GRK3,ROCK2,SOS1,CXCR1,WASL,RASGRP2,CCL19,IKBKG,GNAI2,CCR4,MAP2K1,GNAI3,VAV3,PRKCZ,GSK3B,XCR1 hsa04062 |Chemokine signaling pathway |0.0764357398313813 |-2.57130489335336|182 |92 |0.0285094515029439 |3227 |7161 |SOS1,CXCR1,ROCK2,WASL,RASGRP2,IKBKG,CCL19,GNAI3,MAP2K1,GNAI2,CCR4,PRKCZ,XCR1,GSK3B,VAV3,PARD3,CCL20,ADCY1,CCR1,MAPK1,GRK3,NRAS,STAT5B,CCL28,PRKCD,NFKB1,GNG10,PTK2B,PXN,CCL16,CCR7,CX3CL1,GNAI1,CDC42,FOXO3,FGR,CCL3L3,CRK,ARRB1,PAK1,PLCB4,VAV2,CCR6,CXCL2,CCL25,CXCL5,SRC,GNB5,ROCK1,CXCR5,AKT3,CRKL,GRK5,CCL17,KRAS,ADCY3,ADCY8,STAT3,GNG4,PIK3R1,PIK3R2,ELMO1,ADCY9,RAF1,CXCR4,SHC3,CXCL11,PIK3CB,PTK2,NFKBIA,LYN,PRKACA,GRB2,BCAR1,NFKBIB,GNGT2,BRAF,PREX1,JAK2,PLCB1,GSK3A,STAT1,GNG7,SHC1,ADCY4,CCR8,CXCL8,SHC4,ADCY7,RHOA,GNB4,PIK3R3 ko00280 |Valine, leucine and isoleucine degradation |0.0785279317726801 |-2.544300898722 |48 |27 |0.00836690424542919 |3227 |7161 |MCEE,HMGCS2,AACS,HADHB,ALDH2,ABAT,BCAT2,HADH,ACADS,HMGCLL1,ALDH1B1,ACAA1,ACSF3,PCCB,BCAT1,ALDH7A1,AGXT2,HADHA,HMGCL,AOX1,ACADSB,HIBADH,ACAT2,DBT,IVD,ALDH3A2,BCKDHB hsa00280 |Valine, leucine and isoleucine degradation |0.0785279317726801 |-2.544300898722 |48 |27 |0.00836690424542919 |3227 |7161 |HMGCLL1,ACAA1,ALDH1B1,PCCB,ACSF3,BCAT1,ALDH7A1,HADHA,AGXT2,HMGCL,AOX1,HIBADH,ACADSB,ACAT2,DBT,IVD,ALDH3A2,BCKDHB,MCEE,AACS,HMGCS2,HADHB,ALDH2,ABAT,BCAT2,ACADS,HADH hsa_M00337|Immunoproteasome |0.0831559339875707 |-2.48703771103602|17 |11 |0.00340873876665634 |3227 |7161 |PSMA6,PSMB4,PSMA5,PSMA1,PSMB9,PSMB1,PSMB10,PSMA3,PSMB3,PSMB8,PSMA7 M00337 |Immunoproteasome |0.0831559339875707 |-2.48703771103602|17 |11 |0.00340873876665634 |3227 |7161 |PSMA1,PSMB9,PSMA5,PSMB4,PSMA6,PSMA7,PSMB8,PSMA3,PSMB3,PSMB1,PSMB10 hsa04024 |cAMP signaling pathway |0.0898007820983897 |-2.41016159437572|198 |99 |0.030678648899907 |3227 |7161 |CAMK2B,PTCH1,PPP1CB,ROCK1,PAK1,CALM2,VAV2,SOX9,ACOX1,CAMK2A,ATP2B1,ATP2B3,CNGB1,CNGA2,SLC9A1,GHSR,ATP1B1,CAMK2D,MC2R,GNAI1,CAMK4,CREB3L3,GNAS,CALM1,NFKB1,GIPR,AFDN,CREB3L2,ATP2A2,MAPK1,PDE4B,GRIA3,ARAP3,ADCY1,CREB3L4,GNAI3,PDE4A,MAP2K1,GNAI2,ATP2B2,JUN,VAV3,FXYD2,MYL9,PPP1R1B,CREB3,PLD1,HTR1D,ABCC4,CREBBP,PDE3B,ROCK2,HTR1F,RHOA,ADCY7,PIK3R3,CREB1,PDE4D,ADCY4,DRD2,ACOX3,GRIN2A,PTGER2,ATP2B4,ATP1B3,HCAR2,FFAR2,ORAI1,BRAF,EP300,CREB5,NFKBIA,CALML5,PPP1CC,PRKACA,ATP1A2,PIK3CB,CAMK2G,RAPGEF4,VIPR2,RRAS2,RAF1,ATP1A1,GABBR2,GRIN3B,CACNA1D,PIK3R1,PIK3R2,ADCY9,CREB3L1,FXYD1,ADCY3,ADCY8,FOS,PPARA,AKT3,CNGA3,ADCY10,LIPE ko04024 |cAMP signaling pathway |0.0898007820983897 |-2.41016159437572|198 |99 |0.030678648899907 |3227 |7161 |PDE4D,ADCY4,HTR1F,ADCY7,RHOA,PIK3R3,CREB1,PTGER2,GRIN2A,DRD2,ACOX3,ORAI1,ATP1B3,ATP2B4,HCAR2,FFAR2,CREB5,NFKBIA,CALML5,PPP1CC,PRKACA,BRAF,EP300,CAMK2G,RAPGEF4,VIPR2,ATP1A2,PIK3CB,GABBR2,ATP1A1,GRIN3B,CACNA1D,RRAS2,RAF1,FXYD1,CREB3L1,ADCY8,ADCY3,PIK3R2,PIK3R1,ADCY9,AKT3,CNGA3,PPARA,ADCY10,LIPE,FOS,PAK1,VAV2,CALM2,SOX9,ACOX1,CAMK2A,CAMK2B,ROCK1,PTCH1,PPP1CB,GHSR,ATP2B1,CNGB1,ATP2B3,CNGA2,SLC9A1,CAMK4,CREB3L3,GNAS,CALM1,ATP1B1,CAMK2D,MC2R,GNAI1,GIPR,CREB3L2,AFDN,NFKB1,GRIA3,ARAP3,ADCY1,ATP2A2,MAPK1,PDE4B,CREB3L4,MYL9,FXYD2,PDE4A,GNAI3,MAP2K1,GNAI2,ATP2B2,VAV3,JUN,ABCC4,HTR1D,PDE3B,CREBBP,ROCK2,PPP1R1B,CREB3,PLD1 hsa04971 |Gastric acid secretion |0.0919919606508409 |-2.38605408998131|75 |40 |0.0123954136969321 |3227 |7161 |KCNK10,ACTB,MYLK4,ATP1A1,MYLK3,ITPR1,ADCY1,SLC26A7,CAMK2G,GAST,KCNK2,ATP1A2,ADCY8,ADCY3,ADCY9,GNAI2,ITPR2,GNAI3,ITPR3,PLCB1,MYLK,SLC9A1,KCNJ10,PRKCA,ADCY4,CAMK2A,KCNQ1,CALM2,PLCB4,CAMK2B,ADCY7,PRKACA,CALML5,KCNJ2,CALM1,GNAS,GNAI1,CAMK2D,ATP1B1,ATP1B3 ko04971 |Gastric acid secretion |0.0919919606508409 |-2.38605408998131|75 |40 |0.0123954136969321 |3227 |7161 |ADCY7,CAMK2B,ADCY4,CAMK2A,KCNQ1,CALM2,PLCB4,MYLK,SLC9A1,PRKCA,KCNJ10,ITPR3,PLCB1,GNAI1,CAMK2D,ATP1B1,ATP1B3,CALM1,GNAS,PRKACA,CALML5,KCNJ2,GAST,KCNK2,ATP1A2,ADCY1,ITPR1,SLC26A7,CAMK2G,MYLK3,KCNK10,ACTB,MYLK4,ATP1A1,ADCY9,GNAI2,ITPR2,GNAI3,ADCY3,ADCY8 ko00562 |Inositol phosphate metabolism |0.093773965057487 |-2.36686801951884|71 |38 |0.0117756430120855 |3227 |7161 |PI4K2A,ITPKC,PI4KB,SYNJ2,INPP5D,PIKFYVE,PIK3C3,MTMR4,OCRL,PLCD3,PIK3C2B,ISYNA1,PI4KA,PIK3CB,INPP5B,INPP4A,MTMR7,PLCH2,MTMR3,IMPA2,ITPKB,MTMR2,ITPK1,PIP5K1A,MTMR14,PIP4K2A,INPP1,INPP5A,PLCG2,PLCH1,PLCB4,PIK3C2A,PIK3CG,CDIPT,PIP5K1B,MTM1,PLCB1,PIK3C2G hsa00562 |Inositol phosphate metabolism |0.093773965057487 |-2.36686801951884|71 |38 |0.0117756430120855 |3227 |7161 |INPP5A,PIP4K2A,INPP1,MTMR14,PIP5K1A,MTMR2,ITPK1,ITPKB,PLCB1,PIK3C2G,PIP5K1B,MTM1,CDIPT,PIK3C2A,PLCB4,PIK3CG,PLCG2,PLCH1,PIK3C2B,OCRL,PLCD3,PIK3C3,PIKFYVE,MTMR4,SYNJ2,INPP5D,PI4KB,ITPKC,PI4K2A,IMPA2,MTMR3,MTMR7,INPP4A,PLCH2,PIK3CB,INPP5B,ISYNA1,PI4KA hsa03430 |Mismatch repair |0.094358272151157 |-2.36065633585282|23 |14 |0.00433839479392625 |3227 |7161 |POLD2,MSH2,RPA2,RFC2,MSH6,SSBP1,PCNA,EXO1,RPA1,PMS2,MLH1,RFC1,RPA3,RFC3 ko03430 |Mismatch repair |0.094358272151157 |-2.36065633585282|23 |14 |0.00433839479392625 |3227 |7161 |RFC2,RPA2,MSH2,MSH6,POLD2,PMS2,MLH1,RFC1,RPA3,RFC3,SSBP1,PCNA,EXO1,RPA1 ko04115 |p53 signaling pathway |0.0946452072670633 |-2.35762003898432|69 |37 |0.0114657576696622 |3227 |7161 |PERP,CCND1,STEAP3,CHEK2,TSC2,THBS1,CASP8,BBC3,MDM2,CDKN1A,GADD45A,CCNG2,CASP9,GADD45B,SERPINE1,CCNE1,MDM4,CDK6,SESN3,ATR,IGFBP3,CCND3,COP1,ATM,SIAH1,FAS,CDK4,GADD45G,CHEK1,SESN2,RPRM,TNFRSF10B,CYCS,SESN1,RRM2B,TP73,IGF1 hsa04115 |p53 signaling pathway |0.0946452072670633 |-2.35762003898432|69 |37 |0.0114657576696622 |3227 |7161 |CHEK2,CCND1,PERP,STEAP3,CCNG2,CASP9,GADD45B,SERPINE1,CCNE1,TSC2,MDM2,BBC3,CASP8,THBS1,GADD45A,CDKN1A,CDK4,FAS,GADD45G,CHEK1,SESN2,CDK6,MDM4,ATR,SESN3,CCND3,COP1,IGFBP3,SIAH1,ATM,IGF1,TP73,CYCS,TNFRSF10B,RPRM,SESN1,RRM2B ko00310 |Lysine degradation |0.0986833347678795 |-2.3158391941356 |59 |32 |0.00991633095754571 |3227 |7161 |SETD1B,KMT5C,SETD7,COLGALT2,PIPOX,PRDM9,ACAT2,PLOD1,PLOD3,AADAT,EHMT1,SETD3,HADHA,PLOD2,KMT2A,HADH,NSD2,EZH1,SETMAR,DLST,SETDB1,ALDH2,OGDH,CAMKMT,ALDH3A2,PHYKPL,AASS,KMT2B,ALDH1B1,KMT5A,SETDB2,ALDH7A1 hsa00310 |Lysine degradation |0.0986833347678795 |-2.3158391941356 |59 |32 |0.00991633095754571 |3227 |7161 |KMT5C,COLGALT2,SETD7,PIPOX,SETD1B,SETD3,HADHA,PLOD1,PRDM9,ACAT2,EHMT1,PLOD3,AADAT,DLST,SETMAR,ALDH2,OGDH,SETDB1,KMT2A,PLOD2,HADH,EZH1,NSD2,KMT5A,ALDH1B1,SETDB2,KMT2B,ALDH7A1,CAMKMT,AASS,ALDH3A2,PHYKPL hsa05110 |Vibrio cholerae infection |0.101267710414332 |-2.28998767061939|51 |28 |0.00867678958785249 |3227 |7161 |TJP2,PLCG2,ATP6V0D1,KCNQ1,ATP6V1D,PRKCA,ACTB,ATP6V0A4,ATP6V1C2,ATP6V0C,ATP6V1E2,ATP6V0A1,KDELR3,SEC61A1,ATP6V1C1,ATP6V0D2,ADCY9,SEC61G,ADCY3,ARF1,GNAS,ACTG1,PDIA4,ATP6V1G1,ATP6V0E1,MUC2,ATP6V1G2,PRKACA ko05110 |Vibrio cholerae infection |0.101267710414332 |-2.28998767061939|51 |28 |0.00867678958785249 |3227 |7161 |PRKCA,ATP6V0C,ATP6V0A4,ACTB,ATP6V1C2,ATP6V1C1,SEC61A1,KDELR3,ATP6V1E2,ATP6V0A1,TJP2,ATP6V0D1,PLCG2,KCNQ1,ATP6V1D,MUC2,ATP6V1G2,PRKACA,ADCY9,ATP6V0D2,SEC61G,ACTG1,ARF1,ADCY3,GNAS,ATP6V0E1,ATP6V1G1,PDIA4 hsa03050 |Proteasome |0.102544272587382 |-2.27746064597581|45 |25 |0.00774713356058258 |3227 |7161 |PSMD7,PSMA5,PSMA6,PSMB5,PSMA7,PSMB3,PSMB10,PSMD12,PSMB9,PSMA1,PSMD1,PSMB7,PSMB4,PSME4,PSMF1,PSMD3,ADRM1,PSMB11,PSMC2,PSMD14,PSMB8,SEM1,PSMA3,PSMC4,PSMB1 ko03050 |Proteasome |0.102544272587382 |-2.27746064597581|45 |25 |0.00774713356058258 |3227 |7161 |PSMB10,PSMD12,PSMB3,PSMA7,PSMA6,PSMB5,PSMA5,PSMD7,PSMB1,PSMA3,PSMC4,PSMB8,SEM1,PSMD14,PSMC2,PSME4,PSMB4,PSMF1,PSMB11,PSMD3,ADRM1,PSMD1,PSMB7,PSMB9,PSMA1 ko04960 |Aldosterone-regulated sodium reabsorption |0.102753331201534 |-2.27542400567844|37 |21 |0.00650759219088937 |3227 |7161 |IGF1,ATP1A1,SGK1,NEDD4L,INSR,PRKCA,IRS1,PIK3R3,HSD11B2,PIK3CB,MAPK1,ATP1A2,PDPK1,FXYD2,KRAS,SCNN1B,PIK3R1,PIK3R2,ATP1B1,ATP1B3,NR3C2 M00355 |Spliceosome, 35S U5-snRNP |0.102753331201534 |-2.27542400567844|37 |21 |0.00650759219088937 |3227 |7161 |SNRPB,HSPA1B,SNRPE,GPATCH1,CCDC12,CDC40,PRPF8,HSPA6,SNRNP200,EFTUD2,HSPA8,DHX35,BCAS2,PLRG1,CDC5L,AQR,SNRPD2,SYF2,SNRPG,HSPA1A,BUD31 hsa_M00355|Spliceosome, 35S U5-snRNP |0.102753331201534 |-2.27542400567844|37 |21 |0.00650759219088937 |3227 |7161 |GPATCH1,SNRPE,SNRPB,HSPA1B,PRPF8,CDC40,CCDC12,SNRNP200,HSPA6,DHX35,HSPA8,BCAS2,EFTUD2,CDC5L,PLRG1,SNRPD2,AQR,SNRPG,SYF2,BUD31,HSPA1A hsa04960 |Aldosterone-regulated sodium reabsorption |0.102753331201534 |-2.27542400567844|37 |21 |0.00650759219088937 |3227 |7161 |PDPK1,SCNN1B,KRAS,FXYD2,NR3C2,ATP1B3,ATP1B1,PIK3R2,PIK3R1,ATP1A1,IGF1,PRKCA,INSR,NEDD4L,SGK1,IRS1,MAPK1,ATP1A2,PIK3CB,HSD11B2,PIK3R3 ko04151 |PI3K-Akt signaling pathway |0.113608136245302 |-2.17500015338215|341 |165 |0.0511310814998451 |3227 |7161 |LAMA5,JAK2,RPS6KB2,OSMR,CDKN1A,THBS1,YWHAZ,MTOR,PDGFC,ITGA6,LAMC1,CREB5,PIK3R5,FGF1,KIT,GNGT2,GYS1,PIK3AP1,PKN2,RHEB,VTN,PRLR,VEGFA,SGK1,EIF4B,EFNA5,G6PC,GYS2,SGK3,PIK3CB,AKT3,COL9A3,PDPK1,YWHAQ,IL4R,KRAS,G6PC3,GNG4,PIK3R2,EGF,FGF10,THBS2,FGFR2,INSR,DDIT4,EIF4E2,HSP90AA1,GHR,NRAS,CREB3L2,COMP,PHLPP1,PDGFA,EPHA2,NFKB1,CREB3L3,TNN,CRTC2,ITGA2,COL9A2,FGF3,ITGB3,CREB3L4,IL7R,FGF9,FGF14,PDGFRB,FGF19,PCK1,YWHAG,BCL2,MAPK1,COL4A5,ATF4,CSF3R,KITLG,LAMB3,EFNA1,EIF4E,FN1,MYB,CREB3,CDK4,CCND3,VWF,MAP2K1,FGFR4,ITGA7,PPP2R3B,PDGFRA,SGK2,PRKCA,JAK1,GNG7,LPAR6,FGF2,PCK2,ITGA1,MDM2,IFNAR1,CREB1,GNB4,PIK3R3,LAMB1,PTK2,OSM,GRB2,TEK,FGFR1,PPP2R1B,COL4A4,FGF21,G6PC2,CCND1,NR4A1,IL3,RAF1,YWHAB,BCL2L11,ITGB5,COL6A3,MCL1,LAMB4,FASLG,HSP90AB1,CREB3L1,RPTOR,CDK6,PPP2R5A,PIK3R1,FOXO3,SPP1,CCNE1,VEGFD,CASP9,CSF1,PIK3CG,IRS1,LAMA3,BRCA1,ANGPT4,PPP2R2A,TSC2,GNB5,PPP2R2C,GNG10,PHLPP2,CSF1R,IL7,PPP2R2D,IGF1,RXRA,FGF20,PPP2CA,SOS1,ITGB1,IL6R,BCL2L1,RBL2,FGFR3,EIF4EBP1,PRKAA1,IKBKG,RELN,GSK3B hsa04151 |PI3K-Akt signaling pathway |0.113608136245302 |-2.17500015338215|341 |165 |0.0511310814998451 |3227 |7161 |EIF4B,EFNA5,G6PC,GYS2,PIK3CB,SGK3,RHEB,VTN,VEGFA,PRLR,SGK1,KRAS,G6PC3,GNG4,PIK3R2,AKT3,COL9A3,PDPK1,YWHAQ,IL4R,CDKN1A,OSMR,THBS1,YWHAZ,MTOR,PDGFC,LAMA5,JAK2,RPS6KB2,GYS1,PIK3AP1,PKN2,LAMC1,ITGA6,CREB5,PIK3R5,FGF1,KIT,GNGT2,BCL2,MAPK1,COL4A5,ATF4,CSF3R,CREB3L4,ITGB3,IL7R,FGF9,PDGFRB,FGF14,FGF19,YWHAG,PCK1,CCND3,VWF,MAP2K1,FGFR4,KITLG,LAMB3,EFNA1,FN1,EIF4E,MYB,CREB3,CDK4,DDIT4,EIF4E2,GHR,HSP90AA1,EGF,FGF10,THBS2,FGFR2,INSR,TNN,CREB3L3,CRTC2,ITGA2,FGF3,COL9A2,PHLPP1,CREB3L2,NRAS,COMP,PDGFA,EPHA2,NFKB1,YWHAB,BCL2L11,ITGB5,IL3,RAF1,CREB3L1,RPTOR,PPP2R5A,CDK6,PIK3R1,COL6A3,MCL1,LAMB4,FASLG,HSP90AB1,LPAR6,FGF2,PCK2,ITGA1,MDM2,IFNAR1,GNB4,CREB1,PIK3R3,LAMB1,ITGA7,PDGFRA,PPP2R3B,SGK2,PRKCA,JAK1,GNG7,G6PC2,CCND1,NR4A1,PTK2,OSM,GRB2,TEK,FGFR1,PPP2R1B,FGF21,COL4A4,FGF20,IGF1,RXRA,BCL2L1,RBL2,FGFR3,EIF4EBP1,IKBKG,PRKAA1,RELN,GSK3B,PPP2CA,SOS1,ITGB1,IL6R,IRS1,PIK3CG,LAMA3,ANGPT4,BRCA1,PPP2R2A,TSC2,GNB5,FOXO3,SPP1,CCNE1,VEGFD,CASP9,CSF1,CSF1R,IL7,PPP2R2D,PPP2R2C,PHLPP2,GNG10 hsa04014 |Ras signaling pathway |0.119926586086093 |-2.12087550603133|226 |111 |0.0343972730089867 |3227 |7161 |RASA2,RRAS2,VEGFA,RAF1,TBK1,EFNA5,RGL1,PIK3CB,PLA2G4C,SHC3,PAK4,AKT3,PLA2G1B,REL,FASLG,SYNGAP1,GNG4,PIK3R2,PIK3R1,RALBP1,KRAS,KSR1,ETS2,PRKCA,RALGDS,GNG7,PDGFRA,GRIN2A,PAK3,SHC4,RHOA,PDGFC,PIK3R3,RASAL1,GNB4,ABL2,SHC1,FGF2,PLA2G6,GNGT2,PLA2G2A,FGF21,ABL1,KIT,FGFR1,CALML5,GRB2,FGF1,TEK,PRKACA,RASGRP3,RASAL3,FGF19,PDGFRB,FGF14,GAB2,RAPGEF5,FGF9,IGF1,BRAP,MAPK1,PAK2,FGF20,ARF6,PLD1,KITLG,STK4,EFNA1,SOS1,MAP2K1,RASA3,RAB5C,FGFR4,PTPN11,RASGRP2,FGFR3,BCL2L1,RASSF1,IKBKG,RASGRF2,CSF1,INSR,FGFR2,CDC42,RASGRF1,FGF10,VEGFD,EGF,PLCG2,GNB5,CALM2,PAK1,KSR2,RAB5B,ANGPT4,RALA,EPHA2,RASGRP4,NF1,GNG10,NFKB1,NRAS,AFDN,RALB,MRAS,PDGFA,FGF3,PLA2G4E,RASAL2,CSF1R,CALM1 hsa04120 |Ubiquitin mediated proteolysis |0.120642317035035 |-2.11492516871466|137 |69 |0.0213820886272079 |3227 |7161 |UBE2J1,ANAPC4,CBLB,UBE2O,FBXO4,SKP2,BIRC3,UBE2N,PIAS1,WWP1,CDC34,UBE2H,MAP3K1,NEDD4,ANAPC7,SOCS3,CDC20,UBR5,VHL,UBE2B,TRIM37,SKP1,UBE4A,SMURF1,BRCA1,SYVN1,UBE2I,UBE2Q1,CUL4B,NHLRC1,UBE2G2,RHOBTB2,UBE4B,UBE2E1,CUL2,UBE2C,SMURF2,RHOBTB1,BTRC,UBE2K,UBE2D1,FANCL,UBE2QL1,UBE2W,XIAP,UBE2D4,COP1,WWP2,SIAH1,FBXW11,UBE2J2,RNF7,MDM2,BIRC2,FZR1,NEDD4L,UBOX5,SOCS1,UBE3C,UBE2F,ITCH,ELOC,KEAP1,CUL1,UBE2R2,BIRC6,UBE2G1,FBXW8,UBE2D3 ko04120 |Ubiquitin mediated proteolysis |0.120642317035035 |-2.11492516871466|137 |69 |0.0213820886272079 |3227 |7161 |TRIM37,SKP1,UBE4A,UBE2B,VHL,NEDD4,SOCS3,ANAPC7,UBR5,CDC20,UBE2H,MAP3K1,PIAS1,WWP1,CDC34,FBXO4,UBE2O,SKP2,BIRC3,UBE2N,UBE2J1,ANAPC4,CBLB,SMURF2,RHOBTB1,UBE2C,UBE2E1,CUL2,RHOBTB2,UBE4B,CUL4B,NHLRC1,UBE2G2,SYVN1,UBE2I,UBE2Q1,BRCA1,SMURF1,UBE2J2,RNF7,FBXW11,UBE2D4,COP1,SIAH1,WWP2,FANCL,UBE2W,UBE2QL1,XIAP,UBE2D1,BTRC,UBE2K,BIRC6,UBE2D3,FBXW8,UBE2G1,ELOC,KEAP1,CUL1,UBE2R2,ITCH,UBE3C,UBE2F,NEDD4L,UBOX5,SOCS1,MDM2,BIRC2,FZR1 hsa05210 |Colorectal cancer |0.122683590710022 |-2.09814667125324|60 |32 |0.00991633095754571 |3227 |7161 |MSH2,MSH6,CCND1,SMAD4,AXIN2,AXIN1,TCF7,TGFBR2,BRAF,CTNNB1,RHOA,SMAD3,PIK3R3,TCF7L2,RALGDS,CASP9,KRAS,TGFB3,MAP2K1,PIK3R1,PIK3R2,GSK3B,JUN,AKT3,MLH1,FOS,BCL2,MAPK1,DCC,CYCS,PIK3CB,RAF1 ko05210 |Colorectal cancer |0.122683590710022 |-2.09814667125324|60 |32 |0.00991633095754571 |3227 |7161 |RHOA,SMAD3,PIK3R3,CTNNB1,CASP9,RALGDS,TCF7L2,SMAD4,CCND1,MSH6,MSH2,BRAF,TCF7,TGFBR2,AXIN1,AXIN2,PIK3CB,CYCS,DCC,MAPK1,BCL2,RAF1,GSK3B,PIK3R2,PIK3R1,JUN,MAP2K1,TGFB3,KRAS,FOS,MLH1,AKT3 hsa05132 |Salmonella infection |0.127398603482793 |-2.06043449757768|85 |44 |0.0136349550666253 |3227 |7161 |NFKB1,KLC2,PFN1,ARPC1B,IFNGR2,ARPC5,PKN2,ARPC2,ARPC1A,CCL3L3,RAB7A,RHOG,CDC42,DYNC1I2,MYH10,MAPK13,ROCK1,CXCL8,CXCL2,MYH14,NLRC4,WASF1,MYH9,IFNGR1,WASL,FOS,MAPK14,KLC4,IL1A,ROCK2,DYNC1H1,JUN,LBP,ACTG1,ARPC5L,IL1B,ACTB,WASF2,TLR5,PFN2,CD14,FLNB,DYNC1LI1,MAPK1 ko05132 |Salmonella infection |0.127398603482793 |-2.06043449757768|85 |44 |0.0136349550666253 |3227 |7161 |IL1B,WASF2,ACTB,PFN2,TLR5,FLNB,CD14,DYNC1LI1,MAPK1,WASF1,MYH9,IFNGR1,FOS,WASL,MAPK14,KLC4,ROCK2,IL1A,DYNC1H1,JUN,LBP,ACTG1,ARPC5L,CCL3L3,RAB7A,RHOG,CDC42,DYNC1I2,MYH10,MAPK13,ROCK1,CXCL8,CXCL2,MYH14,NLRC4,KLC2,NFKB1,PFN1,ARPC1B,IFNGR2,ARPC5,PKN2,ARPC2,ARPC1A M00430 |Exon junction complex (EJC) |0.128815829684975 |-2.04937157158277|18 |11 |0.00340873876665634 |3227 |7161 |EIF4A3,MAGOH,CASC3,NXT2,ACIN1,UPF1,SAP18,PNN,RNPS1,NXT1,SRRM1 hsa_M00430|Exon junction complex (EJC) |0.128815829684975 |-2.04937157158277|18 |11 |0.00340873876665634 |3227 |7161 |ACIN1,CASC3,EIF4A3,MAGOH,NXT2,SRRM1,NXT1,UPF1,RNPS1,PNN,SAP18 hsa04930 |Type II diabetes mellitus |0.1312965152365 |-2.03029703849399|46 |25 |0.00774713356058258 |3227 |7161 |PKM,CACNA1A,HK2,PRKCD,PRKCE,ABCC8,PRKCZ,PIK3R2,PIK3R1,SOCS3,MAFA,SOCS2,CACNA1D,SLC2A2,SLC2A4,GCK,INSR,HKDC1,SOCS1,IRS1,CACNA1E,PIK3R3,MTOR,PIK3CB,MAPK1 ko04930 |Type II diabetes mellitus |0.1312965152365 |-2.03029703849399|46 |25 |0.00774713356058258 |3227 |7161 |INSR,HKDC1,SOCS1,CACNA1D,SLC2A4,SLC2A2,GCK,PIK3R3,PIK3CB,MTOR,MAPK1,IRS1,CACNA1E,PKM,CACNA1A,HK2,PRKCE,PRKCD,PIK3R2,PRKCZ,PIK3R1,MAFA,SOCS3,SOCS2,ABCC8 ko00900 |Terpenoid backbone biosynthesis |0.133707477346351 |-2.01210087013775|22 |13 |0.00402850945150294 |3227 |7161 |IDI1,GGPS1,ACAT2,FNTB,FDPS,MVK,HMGCR,HMGCS2,FNTA,RCE1,NUS1,PCYOX1,PDSS2 hsa_M00689|MAPK (p38) signaling |0.133707477346351 |-2.01210087013775|22 |13 |0.00402850945150294 |3227 |7161 |MAP2K6,MAP3K9,MAP3K5,MAPK13,TAOK3,MAP3K12,MAP2K3,TAOK1,MAP3K8,MAP3K1,MAPK14,MAP3K4,MAP3K3 M00689 |MAPK (p38) signaling |0.133707477346351 |-2.01210087013775|22 |13 |0.00402850945150294 |3227 |7161 |MAP2K6,MAP3K9,MAPK13,MAP3K5,TAOK3,MAP3K12,MAP2K3,TAOK1,MAP3K1,MAP3K8,MAPK14,MAP3K4,MAP3K3 hsa_M00009|Citrate cycle (TCA cycle, Krebs cycle) |0.133707477346351 |-2.01210087013775|22 |13 |0.00402850945150294 |3227 |7161 |OGDH,SUCLG1,SUCLG2,DLST,SDHB,IDH3A,IDH2,CS,MDH2,ACO2,IDH1,ACO1,MDH1 hsa00900 |Terpenoid backbone biosynthesis |0.133707477346351 |-2.01210087013775|22 |13 |0.00402850945150294 |3227 |7161 |HMGCS2,FNTA,RCE1,PCYOX1,NUS1,PDSS2,IDI1,GGPS1,FNTB,ACAT2,MVK,FDPS,HMGCR M00009 |Citrate cycle (TCA cycle, Krebs cycle) |0.133707477346351 |-2.01210087013775|22 |13 |0.00402850945150294 |3227 |7161 |ACO1,MDH1,IDH1,ACO2,CS,MDH2,IDH2,SDHB,IDH3A,DLST,SUCLG1,OGDH,SUCLG2 ko04977 |Vitamin digestion and absorption |0.135108789752218 |-2.00167497505007|24 |14 |0.00433839479392625 |3227 |7161 |APOB,SLC19A2,APOA1,SLC23A1,SLC19A3,ABCC1,SLC19A1,BTD,APOA4,MMACHC,SCARB1,SLC46A1,PLB1,LMBRD1 hsa04977 |Vitamin digestion and absorption |0.135108789752218 |-2.00167497505007|24 |14 |0.00433839479392625 |3227 |7161 |PLB1,LMBRD1,MMACHC,SCARB1,SLC46A1,APOA4,ABCC1,BTD,SLC19A1,SLC23A1,SLC19A3,APOB,APOA1,SLC19A2 hsa00500 |Starch and sucrose metabolism |0.135693913308574 |-1.997353567174 |36 |20 |0.00619770684846607 |3227 |7161 |GANC,MGAM2,PGM2,HK2,GYS1,G6PC2,PYGB,GYG1,G6PC3,PGM1,ENPP1,UGP2,ENPP3,GCK,GBE1,PYGL,HKDC1,GYS2,GPI,G6PC ko00500 |Starch and sucrose metabolism |0.135693913308574 |-1.997353567174 |36 |20 |0.00619770684846607 |3227 |7161 |GYG1,G6PC3,GYS1,G6PC2,PYGB,HK2,PGM2,GANC,MGAM2,G6PC,GYS2,GPI,PYGL,HKDC1,GBE1,UGP2,ENPP1,GCK,ENPP3,PGM1 hsa04320 |Dorso-ventral axis formation |0.136492036342713 |-1.9914890078707 |28 |16 |0.00495816547877285 |3227 |7161 |SPIRE2,KRAS,MAP2K1,ETV7,ETV6,NOTCH1,SOS1,GRB2,NOTCH3,BRAF,CPEB2,MAPK1,PIWIL2,CPEB3,ETS2,SPIRE1 ko04320 |Dorso-ventral axis formation |0.136492036342713 |-1.9914890078707 |28 |16 |0.00495816547877285 |3227 |7161 |NOTCH3,BRAF,GRB2,SOS1,MAP2K1,NOTCH1,ETV6,ETV7,KRAS,SPIRE2,ETS2,SPIRE1,PIWIL2,MAPK1,CPEB3,CPEB2 hsa05166 |HTLV-I infection |0.148982639695763 |-1.90392549193371|256 |124 |0.0384257824604896 |3227 |7161 |PPP3CA,BCL2L1,ATM,WNT11,CCND3,IKBKG,MYBL2,TBP,CDC20,IL15,ANAPC7,GSK3B,JUN,CREM,SLC25A4,HLA-DMB,CREBBP,MAP3K3,RAN,LTBR,CDK4,MYB,ELK4,BUB1B,ATF1,NRP1,ADCY1,ATF4,ANAPC4,WNT5A,MAP3K1,SLC2A1,NFKB2,PDGFRB,TNFRSF1A,PTTG2,POLE4,TCF3,POLB,CRTC2,VAC14,SMAD4,FZD5,WNT7B,NRAS,STAT5B,MRAS,PDGFA,DLG1,TBPL2,CHEK2,NFKB1,FZD7,VDAC2,FZD2,CRTC1,KAT2B,MYBL1,WNT10B,TBPL1,SPI1,KRAS,IL1R2,FDPS,POLE3,ADCY3,ADCY8,CANX,TGFB3,VDAC1,ATR,SRF,XIAP,PIK3R2,PIK3R1,ADCY9,AKT3,NFATC3,HLA-DPA1,E2F2,CHEK1,FOS,XBP1,EGR1,PIK3CB,CDKN2B,XPO1,MSX2,RRAS2,IL1R1,CRTC3,ITGB2,ATF3,CCND1,ITGAL,NFKBIA,STAT5A,FZD9,FZD4,PRKACA,BUB3,ZFP36,PCNA,TGFBR2,EP300,CD40,CDKN1A,ICAM1,HLA-DOB,ADCY4,WNT3,POLD2,CTNNB1,NFATC2,ADCY7,PIK3R3,CREB1,SMAD3,MAP3K14,PDGFRA,E2F3,VDAC3,ETS2,JAK1 ko05166 |HTLV-I infection |0.148982639695763 |-1.90392549193371|256 |124 |0.0384257824604896 |3227 |7161 |CCND1,ITGB2,ATF3,IL1R1,CRTC3,CD40,EP300,ZFP36,BUB3,TGFBR2,PCNA,FZD9,FZD4,PRKACA,ITGAL,STAT5A,NFKBIA,ADCY7,NFATC2,PIK3R3,CREB1,SMAD3,MAP3K14,POLD2,WNT3,CTNNB1,HLA-DOB,ADCY4,CDKN1A,ICAM1,JAK1,ETS2,VDAC3,PDGFRA,E2F3,PIK3R2,PIK3R1,ADCY9,SRF,ATR,XIAP,POLE3,FDPS,ADCY3,ADCY8,IL1R2,CANX,VDAC1,TGFB3,KRAS,FOS,CHEK1,E2F2,NFATC3,HLA-DPA1,AKT3,PIK3CB,XBP1,EGR1,RRAS2,MSX2,XPO1,CDKN2B,VAC14,FZD5,SMAD4,CRTC2,POLB,TCF3,TNFRSF1A,PTTG2,POLE4,NFKB1,FZD7,TBPL2,CHEK2,STAT5B,DLG1,MRAS,PDGFA,WNT7B,NRAS,WNT10B,MYBL1,FZD2,KAT2B,CRTC1,VDAC2,SPI1,TBPL1,GSK3B,JUN,IL15,CDC20,TBP,ANAPC7,WNT11,CCND3,IKBKG,MYBL2,PPP3CA,BCL2L1,ATM,CDK4,MYB,ELK4,MAP3K3,RAN,LTBR,CREBBP,SLC25A4,HLA-DMB,CREM,ATF4,ANAPC4,ADCY1,NRP1,ATF1,BUB1B,PDGFRB,NFKB2,SLC2A1,MAP3K1,WNT5A hsa05031 |Amphetamine addiction |0.172377131440387 |-1.75807057780872|68 |35 |0.0108459869848156 |3227 |7161 |PRKCA,GRIN2A,CAMK2B,CREB1,PPP1CB,DDC,CAMK2A,CALM2,CALML5,PRKACA,PPP1CC,CREB5,CREB3L2,CAMK2D,MAOB,FOSB,GNAS,CALM1,CAMK4,CREB3L3,STX1A,GRIN3B,CACNA1D,CREB3L4,ATF4,MAOA,CAMK2G,GRIA3,CREB3,FOS,PPP1R1B,SIRT1,JUN,PPP3CA,CREB3L1 ko05031 |Amphetamine addiction |0.172377131440387 |-1.75807057780872|68 |35 |0.0108459869848156 |3227 |7161 |MAOA,ATF4,GRIA3,CAMK2G,STX1A,CACNA1D,GRIN3B,CREB3L4,JUN,SIRT1,CREB3L1,PPP3CA,FOS,CREB3,PPP1R1B,PPP1CB,CREB1,CAMK2B,CAMK2A,DDC,CALM2,PRKCA,GRIN2A,MAOB,CAMK2D,FOSB,CALM1,GNAS,CAMK4,CREB3L3,PPP1CC,PRKACA,CALML5,CREB3L2,CREB5 hsa00410 |beta-Alanine metabolism |0.179858412631741 |-1.7155853341116 |31 |17 |0.00526805082119616 |3227 |7161 |ALDH7A1,HADHA,ALDH1B1,CNDP2,ALDH3A2,CNDP1,AOC3,ALDH3B1,MLYCD,ALDH2,ABAT,GADL1,SMS,UPB1,ALDH1A3,SMOX,DPYS ko00410 |beta-Alanine metabolism |0.179858412631741 |-1.7155853341116 |31 |17 |0.00526805082119616 |3227 |7161 |HADHA,ALDH7A1,ALDH1B1,ALDH3A2,CNDP2,CNDP1,AOC3,ALDH3B1,ABAT,MLYCD,ALDH2,GADL1,SMS,DPYS,UPB1,SMOX,ALDH1A3 ko04392 |Hippo signaling pathway -multiple species |0.181430090028979 |-1.70688487838137|29 |16 |0.00495816547877285 |3227 |7161 |LATS2,RASSF1,WWTR1,YAP1,RASSF6,SAV1,STK3,FRMD6,TEAD4,TEAD1,PAK1,RASSF2,LIMD1,WWC1,CSNK1E,FRMD1 hsa05216 |Thyroid cancer |0.181430090028979 |-1.70688487838137|29 |16 |0.00495816547877285 |3227 |7161 |RXRB,CDH1,MAPK1,CTNNB1,TCF7L2,TPM3,PPARG,NCOA4,RXRA,PAX8,KRAS,MAP2K1,CCND1,NRAS,BRAF,TCF7 ko05216 |Thyroid cancer |0.181430090028979 |-1.70688487838137|29 |16 |0.00495816547877285 |3227 |7161 |TCF7,BRAF,NRAS,CCND1,MAP2K1,KRAS,PAX8,NCOA4,RXRA,PPARG,TPM3,TCF7L2,CTNNB1,MAPK1,CDH1,RXRB hsa04392 |Hippo signaling pathway -multiple species |0.181430090028979 |-1.70688487838137|29 |16 |0.00495816547877285 |3227 |7161 |WWTR1,RASSF1,LATS2,FRMD6,STK3,RASSF6,SAV1,YAP1,LIMD1,RASSF2,TEAD1,PAK1,TEAD4,CSNK1E,FRMD1,WWC1 ko04964 |Proximal tubule bicarbonate reclamation |0.184861444097692 |-1.68814868533088|23 |13 |0.00402850945150294 |3227 |7161 |ATP1B1,ATP1A2,ATP1B3,GLS,GLS2,FXYD2,PCK2,MDH1,PCK1,SLC38A3,CA4,SLC25A10,ATP1A1 hsa04964 |Proximal tubule bicarbonate reclamation |0.184861444097692 |-1.68814868533088|23 |13 |0.00402850945150294 |3227 |7161 |PCK1,SLC38A3,CA4,SLC25A10,ATP1A1,ATP1A2,ATP1B1,GLS,ATP1B3,GLS2,FXYD2,PCK2,MDH1 hsa00220 |Arginine biosynthesis |0.185338775048603 |-1.68556991205767|21 |12 |0.00371862410907964 |3227 |7161 |NOS1,GOT2,ARG1,GPT,ASS1,GOT1,GPT2,GLS,CPS1,OTC,ASL,GLS2 ko00220 |Arginine biosynthesis |0.185338775048603 |-1.68556991205767|21 |12 |0.00371862410907964 |3227 |7161 |ASS1,GOT1,GPT,ARG1,GOT2,NOS1,ASL,GLS2,OTC,CPS1,GLS,GPT2 hsa03018 |RNA degradation |0.190520789279424 |-1.65799396029392|77 |39 |0.0120855283545088 |3227 |7161 |PABPC3,DDX6,MPHOSPH6,LSM3,CNOT8,CNOT10,DIS3,LSM2,XRN2,TENT4A,WDR61,CNOT7,CNOT9,DCP1A,TOB2,PFKP,HSPA9,PFKL,EXOSC3,LSM4,DCP1B,CNOT2,PNPT1,PATL1,CNOT6,PARN,TOB1,TENT4B,PABPC1,DCP2,EXOSC9,CNOT6L,CNOT1,BTG1,EDC4,EDC3,PABPC1L,LSM1,XRN1 ko03018 |RNA degradation |0.190520789279424 |-1.65799396029392|77 |39 |0.0120855283545088 |3227 |7161 |EDC4,BTG1,PABPC1L,LSM1,EDC3,XRN1,CNOT6,PARN,DCP2,EXOSC9,TENT4B,TOB1,PABPC1,CNOT1,CNOT6L,CNOT9,CNOT7,PFKP,DCP1A,TOB2,PFKL,EXOSC3,HSPA9,PATL1,CNOT2,PNPT1,LSM4,DCP1B,PABPC3,MPHOSPH6,CNOT8,LSM3,DDX6,LSM2,XRN2,CNOT10,DIS3,WDR61,TENT4A hsa04728 |Dopaminergic synapse |0.190698807621066 |-1.65706001903786|130 |64 |0.0198326619150914 |3227 |7161 |KIF5B,MAOB,CALML5,PRKACA,PPP1CC,CREB5,GNGT2,PPP2R1B,DDC,GNAL,MAPK13,CREB1,GNB4,GRIN2A,DRD2,ITPR3,PPP2R3B,PLCB1,GSK3A,GNG7,PRKCA,CREB3L1,PPP2R5A,GNG4,AKT3,FOS,KCNJ3,CAMK2G,SCN1A,DRD4,MAOA,CACNA1D,GNAS,CALM1,CREB3L3,CAMK2D,PPP2R2D,GNAI1,CREB3L2,PPP2R2C,GNG10,CAMK2A,PPP2R2A,PLCB4,CALM2,GNB5,CAMK2B,COMT,PPP1CB,PPP3CA,GSK3B,GNAI3,GNAI2,ITPR2,PPP2CA,CREB3,PPP1R1B,CACNA1A,MAPK14,ITPR1,GRIA3,ATF4,CREB3L4,ARNTL ko04728 |Dopaminergic synapse |0.190698807621066 |-1.65706001903786|130 |64 |0.0198326619150914 |3227 |7161 |MAOA,DRD4,SCN1A,CAMK2G,KCNJ3,CACNA1D,GNG4,PPP2R5A,CREB3L1,FOS,AKT3,GNB4,CREB1,MAPK13,GNAL,DDC,PRKCA,GNG7,GSK3A,PLCB1,PPP2R3B,ITPR3,DRD2,GRIN2A,MAOB,KIF5B,PPP2R1B,GNGT2,CREB5,PPP1CC,PRKACA,CALML5,ATF4,GRIA3,ITPR1,ARNTL,CREB3L4,ITPR2,GNAI2,GNAI3,GSK3B,PPP3CA,MAPK14,CACNA1A,PPP1R1B,CREB3,PPP2CA,PPP1CB,COMT,CAMK2B,GNB5,PLCB4,CALM2,CAMK2A,PPP2R2A,GNAI1,PPP2R2D,CAMK2D,CREB3L3,CALM1,GNAS,GNG10,CREB3L2,PPP2R2C hsa00520 |Amino sugar and nucleotide sugar metabolism |0.20151273331708 |-1.60190270695137|48 |25 |0.00774713356058258 |3227 |7161 |GALT,GPI,UGP2,CHIT1,GCK,PGM3,GALE,PGM1,HKDC1,UAP1,PMM1,UGDH,HEXB,GNE,GNPNAT1,NANS,GFPT2,GMPPB,FCSK,TSTA3,UXS1,HK2,GFPT1,PGM2,GMDS ko00520 |Amino sugar and nucleotide sugar metabolism |0.20151273331708 |-1.60190270695137|48 |25 |0.00774713356058258 |3227 |7161 |PGM3,GALE,PGM1,CHIT1,UGP2,GCK,GNE,UAP1,HKDC1,HEXB,PMM1,UGDH,GALT,GPI,TSTA3,PGM2,GMDS,HK2,UXS1,GFPT1,GFPT2,NANS,GNPNAT1,FCSK,GMPPB hsa05218 |Melanoma |0.203533018396041 |-1.59192703470061|69 |35 |0.0108459869848156 |3227 |7161 |IGF1,FGF9,FGF14,PDGFRB,FGF19,RAF1,FGF20,MAPK1,PIK3CB,AKT3,E2F2,CDK4,KRAS,MAP2K1,CDK6,PIK3R1,PIK3R2,E2F3,PDGFRA,EGF,FGF10,CDH1,CDKN1A,FGF2,MDM2,PIK3R3,PDGFC,NRAS,PDGFA,FGF1,FGFR1,FGF21,BRAF,CCND1,FGF3 ko05218 |Melanoma |0.203533018396041 |-1.59192703470061|69 |35 |0.0108459869848156 |3227 |7161 |IGF1,FGF9,FGF19,PDGFRB,FGF14,RAF1,FGF20,MAPK1,PIK3CB,AKT3,E2F2,CDK4,KRAS,MAP2K1,PIK3R2,PIK3R1,CDK6,PDGFRA,E2F3,FGF10,EGF,CDKN1A,CDH1,MDM2,FGF2,PDGFC,PIK3R3,NRAS,FGFR1,FGF1,PDGFA,BRAF,FGF21,CCND1,FGF3 hsa00983 |Drug metabolism - other enzymes |0.204741100886121 |-1.58600902050917|46 |24 |0.00743724821815928 |3227 |7161 |UGT1A5,DPYS,UPP1,UPB1,UGT1A4,IMPDH2,TYMP,IMPDH1,UCK1,CES1,CYP3A4,UMPS,UGT2A3,GUSB,UCK2,CYP2A6,UGT2B15,UGT2B4,TK2,UPP2,XDH,UGT2B10,UGT2B7,ITPA ko00983 |Drug metabolism - other enzymes |0.204741100886121 |-1.58600902050917|46 |24 |0.00743724821815928 |3227 |7161 |CYP3A4,CES1,TYMP,IMPDH1,UCK1,UGT1A4,IMPDH2,UPB1,DPYS,UPP1,UGT1A5,XDH,UPP2,UGT2B7,UGT2B10,ITPA,TK2,UGT2B4,CYP2A6,UCK2,UGT2B15,UGT2A3,GUSB,UMPS hsa00190 |Oxidative phosphorylation |0.206303840781953 |-1.57840524161845|120 |59 |0.0182832352029749 |3227 |7161 |SDHB,UQCRB,COX5A,UQCRC2,NDUFAB1,COX6B1,UQCRC1,NDUFS7,ATP6V0E1,COX7A2L,NDUFB4,NDUFS5,UQCRFS1,UQCRHL,LHPP,ATP5MC1,ATP6V0C,ATP6V1C2,COX6A1,ATP5PF,NDUFA8,NDUFS4,ATP6V1C1,ATP5MG,COX4I1,NDUFB11,UQCR10,ATP6V1D,PPA2,ATP5PO,COX11,ATP6V0D1,ATP5F1D,NDUFA4,COX7A2,COX4I2,ATP5MC3,ATP5F1C,COX6C,ATP6V1G2,NDUFC1,ATP5F1A,NDUFS1,NDUFB7,ATP6V1G1,COX5B,NDUFB6,ATP6V0D2,ATP5ME,NDUFB9,ATP6V0A4,COX8A,NDUFA11,ATP6V0A1,ATP6V1E2,NDUFB3,NDUFA12,NDUFV2,ATP5MC2 ko00190 |Oxidative phosphorylation |0.206303840781953 |-1.57840524161845|120 |59 |0.0182832352029749 |3227 |7161 |ATP5ME,COX5B,ATP6V0D2,NDUFB6,NDUFB7,ATP6V1G1,NDUFC1,ATP5F1A,NDUFS1,COX6C,ATP6V1G2,ATP5F1C,ATP5MC3,COX7A2,COX4I2,ATP5MC2,NDUFA12,NDUFV2,COX8A,NDUFA11,ATP6V0A1,NDUFB3,ATP6V1E2,NDUFB9,ATP6V0A4,UQCRHL,LHPP,ATP5MC1,UQCRFS1,COX7A2L,ATP6V0E1,NDUFB4,NDUFS5,UQCRC1,NDUFS7,COX6B1,UQCRC2,NDUFAB1,SDHB,UQCRB,COX5A,ATP6V0D1,COX11,NDUFA4,ATP5F1D,ATP5PO,ATP6V1D,PPA2,UQCR10,COX4I1,NDUFB11,ATP5MG,ATP6V1C1,ATP6V0C,ATP6V1C2,COX6A1,NDUFA8,NDUFS4,ATP5PF hsa04720 |Long-term potentiation |0.206982315618569 |-1.57512192116062|67 |34 |0.0105361016423923 |3227 |7161 |CAMK2D,RPS6KA1,CAMK4,CALM1,EP300,BRAF,NRAS,PPP1CC,PRKACA,CALML5,PPP1R1A,PPP1CB,CAMK2B,PLCB4,CALM2,CAMK2A,RPS6KA3,PRKCA,PLCB1,ITPR3,GRIN2A,ITPR2,MAP2K1,KRAS,PPP3CA,ADCY8,CREBBP,MAPK1,ATF4,CAMK2G,ITPR1,ADCY1,RPS6KA2,RAF1 ko04720 |Long-term potentiation |0.206982315618569 |-1.57512192116062|67 |34 |0.0105361016423923 |3227 |7161 |BRAF,EP300,CALML5,PPP1CC,PRKACA,NRAS,CAMK2D,RPS6KA1,CALM1,CAMK4,PRKCA,RPS6KA3,GRIN2A,ITPR3,PLCB1,CAMK2B,PPP1CB,PPP1R1A,CAMK2A,CALM2,PLCB4,CREBBP,MAP2K1,ITPR2,ADCY8,PPP3CA,KRAS,RAF1,RPS6KA2,ATF4,MAPK1,ITPR1,ADCY1,CAMK2G hsa05152 |Tuberculosis |0.209766550185268 |-1.56176003240783|178 |86 |0.0266501394484041 |3227 |7161 |FCGR3A,ATP6V0C,LAMP2,NFYC,BCL2,MAPK1,CYCS,ITGAX,IL23A,HLA-DMB,CREBBP,SPHK1,MAPK14,ITGAM,PIK3C3,PPP3CA,RFXAP,LBP,TLR6,RAB5C,CASP9,NOD2,RAB7A,CALM2,VDR,RAB5B,CAMK2A,CASP8,SRC,CAMK2B,IRAK1,ARHGEF12,NFKB1,CARD9,TNFRSF1A,IL10RB,CALM1,CAMK2D,RIPK2,CD14,RAF1,IL1B,CAMK2G,HSPA9,CIITA,ATP6V0D1,AKT3,HLA-DPA1,IL1A,CEBPB,CASP10,CORO1A,C3,MALT1,IFNGR1,KSR1,TGFB3,SPHK2,BCL10,JAK2,ATP6V0A1,ATP6V0A4,FCGR2A,LAMP1,PLK3,STAT1,JAK1,HLA-DOB,MRC2,EEA1,MAPK13,RHOA,IL12A,CREB1,IRAK2,IFNGR2,CALML5,CTSD,CYP27B1,CEBPG,CAMP,NFYA,EP300,TLR9,ITGB2,ATP6V0D2 ko05152 |Tuberculosis |0.209766550185268 |-1.56176003240783|178 |86 |0.0266501394484041 |3227 |7161 |ATP6V0D2,ITGB2,TLR9,CAMP,NFYA,EP300,CEBPG,CYP27B1,CALML5,CTSD,IFNGR2,IRAK2,MAPK13,IL12A,RHOA,CREB1,HLA-DOB,EEA1,MRC2,JAK1,PLK3,LAMP1,STAT1,ATP6V0A4,FCGR2A,ATP6V0A1,JAK2,SPHK2,BCL10,KSR1,TGFB3,IFNGR1,CASP10,CEBPB,CORO1A,C3,MALT1,IL1A,HLA-DPA1,AKT3,ATP6V0D1,CIITA,CAMK2G,HSPA9,RAF1,IL1B,RIPK2,CD14,CAMK2D,CALM1,TNFRSF1A,CARD9,IL10RB,NFKB1,ARHGEF12,IRAK1,SRC,CAMK2B,VDR,CAMK2A,RAB5B,CASP8,CALM2,CASP9,NOD2,RAB7A,RAB5C,LBP,TLR6,RFXAP,PPP3CA,PIK3C3,SPHK1,ITGAM,MAPK14,CREBBP,HLA-DMB,ITGAX,CYCS,IL23A,MAPK1,BCL2,NFYC,LAMP2,ATP6V0C,FCGR3A hsa05222 |Small cell lung cancer |0.210299075614841 |-1.55922459183787|84 |42 |0.0130151843817787 |3227 |7161 |PTK2,NFKBIA,LAMC1,ITGA6,NFKB1,COL4A4,ITGA2,CCND1,LAMA5,E2F3,CCNE1,CASP9,LAMA3,RXRB,BIRC2,LAMB1,PIK3R3,AKT3,LAMB3,E2F2,LAMB4,FN1,TRAF3,ITGB1,CDK4,BCL2L1,IKBKG,XIAP,CDK6,RARB,PIK3R1,PIK3R2,CDKN2B,RXRA,TRAF2,TRAF1,BIRC3,BCL2,SKP2,COL4A5,PIK3CB,CYCS ko05222 |Small cell lung cancer |0.210299075614841 |-1.55922459183787|84 |42 |0.0130151843817787 |3227 |7161 |CASP9,CCNE1,E2F3,LAMA5,LAMB1,PIK3R3,BIRC2,RXRB,LAMA3,NFKB1,COL4A4,PTK2,ITGA6,NFKBIA,LAMC1,CCND1,ITGA2,RXRA,CDKN2B,PIK3CB,CYCS,COL4A5,SKP2,BCL2,BIRC3,TRAF1,TRAF2,CDK4,FN1,TRAF3,ITGB1,E2F2,LAMB3,LAMB4,AKT3,PIK3R1,RARB,PIK3R2,CDK6,XIAP,IKBKG,BCL2L1 hsa00860 |Porphyrin and chlorophyll metabolism |0.211376895789775 |-1.55411250295784|42 |22 |0.00681747753331267 |3227 |7161 |UROD,EARS2,UGT1A4,ALAD,ALAS1,CPOX,FXN,EPRS,UGT1A5,BLVRA,CP,UGT2B7,UGT2B10,MMAB,UGT2B4,FECH,UGT2B15,UGT2A3,GUSB,BLVRB,HMBS,HMOX1 ko00860 |Porphyrin and chlorophyll metabolism |0.211376895789775 |-1.55411250295784|42 |22 |0.00681747753331267 |3227 |7161 |HMOX1,UGT2A3,GUSB,HMBS,BLVRB,UGT2B4,FECH,UGT2B15,UGT2B7,UGT2B10,MMAB,ALAS1,FXN,CPOX,EPRS,CP,BLVRA,UGT1A5,ALAD,UGT1A4,UROD,EARS2 ko04380 |Osteoclast differentiation |0.217422468242331 |-1.52591295985452|129 |63 |0.0195227765726681 |3227 |7161 |FYN,NFKB2,IL1B,FCGR3A,ITGB3,PPARG,GAB2,MAPK1,PIK3CB,TRAF2,MAPK14,IFNGR1,FOS,AKT3,IL1A,SOCS3,MAP2K1,IRF9,NOX1,JUN,PIK3R1,CYBA,PIK3R2,PPP3CA,IKBKG,SQSTM1,STAT1,SOCS1,BLNK,JAK1,CSF1,SPI1,FCGR2A,TYK2,TAB2,IFNAR1,PLCG2,PIK3R3,CREB1,MAP3K14,MAPK13,TAB1,NFATC2,NCF2,NOX3,TGFBR2,TNFRSF11A,NFKB1,JUNB,NFKBIA,IFNGR2,GRB2,FOSL2,SIRPA,TYROBP,FOSB,FHL2,MAP2K7,CSF1R,IL1R1,MAP2K6,CAMK4,TNFRSF1A hsa04380 |Osteoclast differentiation |0.217422468242331 |-1.52591295985452|129 |63 |0.0195227765726681 |3227 |7161 |CREB1,MAP3K14,PIK3R3,MAPK13,NFATC2,NCF2,TAB1,TAB2,IFNAR1,PLCG2,NOX3,BLNK,JAK1,CSF1,STAT1,SOCS1,FCGR2A,TYK2,SPI1,MAP2K7,TYROBP,FHL2,FOSB,CSF1R,CAMK4,TNFRSF1A,IL1R1,MAP2K6,NFKB1,TGFBR2,TNFRSF11A,GRB2,FOSL2,SIRPA,JUNB,NFKBIA,IFNGR2,PIK3CB,MAPK1,TRAF2,IL1B,FYN,NFKB2,GAB2,FCGR3A,PPARG,ITGB3,NOX1,IRF9,JUN,PIK3R1,CYBA,PIK3R2,SOCS3,MAP2K1,IKBKG,SQSTM1,PPP3CA,FOS,IFNGR1,MAPK14,IL1A,AKT3 hsa05161 |Hepatitis B |0.217513412052981 |-1.52549476574317|144 |70 |0.0216919739696312 |3227 |7161 |PIK3R1,CDK6,PIK3R2,TGFB3,STAT3,CREB3L1,KRAS,FOS,CASP10,YWHAQ,E2F2,FASLG,AKT3,NFATC3,PIK3CB,YWHAB,RAF1,TBK1,CCND1,DDX3X,EP300,STAT6,PCNA,GRB2,CREB5,NFKBIA,STAT5A,NFATC2,PIK3R3,SMAD3,CREB1,IFNAR1,CXCL8,EGR3,YWHAZ,CDKN1A,JAK1,VDAC3,PRKCA,STAT1,E2F3,JUN,MAP2K1,IKBKG,CREB3,CDK4,FAS,CREBBP,MMP9,CYCS,CCNA2,ATF4,MAPK1,BCL2,MAP3K1,CREB3L4,SMAD4,DDX58,CREB3L3,NFKB1,PTK2B,STAT5B,NRAS,CREB3L2,SRC,HSPG2,CASP8,MAVS,CASP9,CCNE1 hsa04130 |SNARE interactions in vesicular transport |0.225336276709448 |-1.49016142937256|34 |18 |0.00557793616361946 |3227 |7161 |BNIP1,STX1A,VAMP5,STX2,VAMP1,SNAP29,STX1B,GOSR2,STX4,SEC22B,STX8,VAMP8,GOSR1,VAMP3,STX11,STX16,STX6,VAMP2 ko04130 |SNARE interactions in vesicular transport |0.225336276709448 |-1.49016142937256|34 |18 |0.00557793616361946 |3227 |7161 |STX1B,GOSR2,STX4,BNIP1,STX1A,VAMP5,STX2,VAMP1,SNAP29,VAMP3,STX11,STX16,STX6,VAMP2,SEC22B,STX8,VAMP8,GOSR1 hsa00640 |Propanoate metabolism |0.228952347475378 |-1.47424138670872|32 |17 |0.00526805082119616 |3227 |7161 |DBT,ACAT2,BCKDHB,PCCB,ACSS3,HADHA,LDHA,LDHAL6B,ACSS1,ACACB,MCEE,ACACA,MLYCD,SUCLG1,SUCLG2,ACSS2,ABAT ko00640 |Propanoate metabolism |0.228952347475378 |-1.47424138670872|32 |17 |0.00526805082119616 |3227 |7161 |ACACB,LDHAL6B,ACSS1,ACSS2,ABAT,MLYCD,SUCLG1,SUCLG2,ACACA,MCEE,BCKDHB,ACAT2,DBT,HADHA,LDHA,PCCB,ACSS3 hsa05134 |Legionellosis |0.229605758177828 |-1.47139153567948|55 |28 |0.00867678958785249 |3227 |7161 |NFKBIA,BNIP3,RAB1A,EEF1A1,C3,ITGAM,SEC22B,NFKB1,HSPA1A,ARF1,ITGB2,CD14,TLR5,CLK1,NFKB2,SAR1B,IL1B,HSPA1B,CASP9,NLRC4,CASP8,CXCL2,HSPA8,CXCL8,HBS1L,CYCS,IL12A,HSPA6 ko05134 |Legionellosis |0.229605758177828 |-1.47139153567948|55 |28 |0.00867678958785249 |3227 |7161 |HSPA1A,ARF1,ITGB2,NFKB1,ITGAM,C3,SEC22B,EEF1A1,RAB1A,BNIP3,NFKBIA,IL12A,CYCS,HSPA6,HBS1L,CXCL8,CXCL2,CASP8,HSPA8,NLRC4,CASP9,HSPA1B,SAR1B,IL1B,NFKB2,CLK1,TLR5,CD14 hsa00020 |Citrate cycle (TCA cycle) |0.232606489619999 |-1.45840713894284|30 |16 |0.00495816547877285 |3227 |7161 |IDH1,IDH2,CS,SDHB,ACLY,ACO2,ACO1,PCK2,MDH1,MDH2,DLST,IDH3A,OGDH,SUCLG1,SUCLG2,PCK1 ko00020 |Citrate cycle (TCA cycle) |0.232606489619999 |-1.45840713894284|30 |16 |0.00495816547877285 |3227 |7161 |SUCLG2,SUCLG1,OGDH,PCK1,DLST,IDH3A,MDH2,ACO2,ACLY,MDH1,PCK2,ACO1,SDHB,IDH2,CS,IDH1 ko04662 |B cell receptor signaling pathway |0.237309705119364 |-1.43838921827574|70 |35 |0.0108459869848156 |3227 |7161 |NFKB1,NFKBIB,NFKBIA,NRAS,GRB2,LYN,RASGRP3,PIK3AP1,BLNK,PLCG2,PIK3R3,NFATC2,VAV2,INPP5D,MALT1,FOS,AKT3,NFATC3,SOS1,BCL10,MAP2K1,JUN,VAV3,PIK3R2,PIK3R1,GSK3B,KRAS,PPP3CA,IKBKG,CD81,RAF1,MAPK1,PIK3CB,CARD11,IFITM1 hsa04662 |B cell receptor signaling pathway |0.237309705119364 |-1.43838921827574|70 |35 |0.0108459869848156 |3227 |7161 |KRAS,PPP3CA,IKBKG,CD81,BCL10,MAP2K1,JUN,VAV3,GSK3B,PIK3R1,PIK3R2,NFATC3,AKT3,SOS1,INPP5D,MALT1,FOS,IFITM1,CARD11,MAPK1,PIK3CB,RAF1,PIK3AP1,RASGRP3,NFKBIA,NRAS,GRB2,LYN,NFKB1,NFKBIB,VAV2,PLCG2,PIK3R3,NFATC2,BLNK ko05030 |Cocaine addiction |0.242369296314105 |-1.41729269818057|49 |25 |0.00774713356058258 |3227 |7161 |CREB3L4,GRIN3B,DRD2,GRIN2A,MAOA,ATF4,CREB1,RGS9,DDC,PPP1R1B,NFKB1,CREB3,CREB3L2,CREB5,PRKACA,GNAI2,GNAI3,FOSB,GNAI1,JUN,MAOB,CREB3L1,CREB3L3,CDK5R1,GNAS hsa05030 |Cocaine addiction |0.242369296314105 |-1.41729269818057|49 |25 |0.00774713356058258 |3227 |7161 |CREB1,ATF4,MAOA,DDC,RGS9,DRD2,GRIN2A,GRIN3B,CREB3L4,MAOB,GNAI1,JUN,FOSB,GNAI3,GNAI2,GNAS,CDK5R1,CREB3L1,CREB3L3,NFKB1,CREB3,PPP1R1B,PRKACA,CREB5,CREB3L2 hsa05169 |Epstein-Barr virus infection |0.242590910925219 |-1.41637874844518|199 |95 |0.0294391075302138 |3227 |7161 |ITGAL,NFKBIA,LYN,PRKACA,POLR3B,CSNK2B,NFKBIB,CD40,EP300,MAP2K6,PSMD14,POLR3H,MAP2K7,JAK1,CDKN1A,ICAM1,RBPJ,MDM2,YWHAZ,RIPK1,POLR3GL,TAB2,MAPK13,TAB1,HSPA6,PIK3R3,MAP3K14,AKT3,HLA-DPA1,AKAP8L,TRAF3,YWHAQ,ADRM1,POLR1D,STAT3,PIK3R2,PIK3R1,TBK1,MAP2K3,XPO1,HDAC5,YWHAB,TRAF1,HSPA8,USP7,HDAC4,PIK3CB,POLR2D,IRAK1,TBPL2,GTF2B,NFKB1,SEM1,CD38,IL10RB,EIF2AK3,DDX58,TBPL1,PTMA,FGR,NCOR2,SPI1,TYK2,CSNK2A2,NUP214,HDAC2,PLCG2,PSMD12,PSMD1,POLR3E,CREBBP,PSMC2,RAN,MAPK14,PSMD3,HSPA1A,IKBKG,TBP,GSK3B,JUN,NEDD4,PSMC4,PSMD7,NFKB2,POLR2A,HSPA1B,YWHAG,POLR2E,POLR3A,TRAF2,BCL2,SKP2,CSNK2A1,HSPB1,CCNA2 ko05169 |Epstein-Barr virus infection |0.242590910925219 |-1.41637874844518|199 |95 |0.0294391075302138 |3227 |7161 |PSMD1,POLR3E,CREBBP,RAN,PSMC2,MAPK14,PSMD3,HSPA1A,IKBKG,TBP,GSK3B,PSMC4,JUN,NEDD4,PSMD7,NFKB2,POLR2A,YWHAG,POLR2E,HSPA1B,POLR3A,TRAF2,BCL2,SKP2,HSPB1,CSNK2A1,CCNA2,IRAK1,TBPL2,GTF2B,NFKB1,CD38,SEM1,EIF2AK3,IL10RB,DDX58,PTMA,TBPL1,FGR,NCOR2,CSNK2A2,TYK2,SPI1,NUP214,HDAC2,PLCG2,PSMD12,AKT3,HLA-DPA1,AKAP8L,TRAF3,YWHAQ,ADRM1,POLR1D,STAT3,PIK3R1,PIK3R2,TBK1,MAP2K3,XPO1,HDAC5,TRAF1,YWHAB,HSPA8,USP7,PIK3CB,HDAC4,POLR2D,ITGAL,NFKBIA,LYN,POLR3B,PRKACA,CSNK2B,NFKBIB,CD40,EP300,MAP2K6,PSMD14,POLR3H,MAP2K7,JAK1,CDKN1A,ICAM1,RBPJ,MDM2,YWHAZ,RIPK1,POLR3GL,TAB2,HSPA6,MAPK13,TAB1,MAP3K14,PIK3R3 ko00534 |Glycosaminoglycan biosynthesis - heparan sulfate / heparin |0.243660035596999 |-1.41198132196297|24 |13 |0.00402850945150294 |3227 |7161 |HS3ST2,XYLT2,NDST2,EXT1,HS2ST1,NDST1,EXTL3,B3GAT3,HS3ST5,GLCE,B3GALT6,HS6ST1,EXTL1 hsa00534 |Glycosaminoglycan biosynthesis - heparan sulfate / heparin |0.243660035596999 |-1.41198132196297|24 |13 |0.00402850945150294 |3227 |7161 |NDST1,HS2ST1,EXTL3,XYLT2,EXT1,NDST2,HS3ST2,HS6ST1,EXTL1,HS3ST5,GLCE,B3GAT3,B3GALT6 ko04961 |Endocrine and other factor-regulated calcium reabsorption |0.246878442430342 |-1.39885919940233|47 |24 |0.00743724821815928 |3227 |7161 |AP2A2,PRKACA,ESR1,PTH1R,AP2A1,GNAS,FXYD2,BDKRB2,ADCY9,AP2M1,ATP1B3,ATP1B1,PLCB1,ATP1A1,ATP2B1,PRKCA,DNM2,VDR,AP2B1,PLCB4,RAB11A,AP2S1,KL,ATP1A2 hsa04961 |Endocrine and other factor-regulated calcium reabsorption |0.246878442430342 |-1.39885919940233|47 |24 |0.00743724821815928 |3227 |7161 |DNM2,PRKCA,ATP2B1,PLCB1,ATP1A1,ATP1A2,KL,AP2S1,RAB11A,PLCB4,AP2B1,VDR,AP2A1,PTH1R,ESR1,PRKACA,AP2A2,ATP1B1,ATP1B3,ADCY9,AP2M1,BDKRB2,FXYD2,GNAS ko04621 |NOD-like receptor signaling pathway |0.248064259967568 |-1.39406745360862|169 |81 |0.0251007127362876 |3227 |7161 |TXN,NOD2,TYK2,HSP90AA1,VDAC2,MAVS,PLCB4,NLRC4,CXCL2,CASP8,PRKCD,NFKB1,SUGT1,ANTXR2,PANX1,CARD9,GSDMD,RNASEL,TMEM173,PYDC2,MAPK1,BIRC3,TRAF2,ITPR1,BCL2,MAPK14,ATG16L1,TRPM2,ITPR2,JUN,IRF9,NOX1,MCU,CYBA,BCL2L1,IKBKG,TRPV2,STAT1,ATG5,VDAC3,RBCK1,JAK1,PLCB1,CASP4,ITPR3,CXCL8,TAB2,IFNAR1,ERBIN,RHOA,TANK,MAPK13,TAB1,GABARAPL2,TRPM7,NOX3,RIPK1,BIRC2,ANTXR1,CAMP,NFKBIB,NFKBIA,IL1B,TBK1,RIPK2,MFN2,P2RX7,GABARAPL1,TRAF3,HSP90AB1,MEFV,TAB3,XIAP,TXN2,DNM1L,NLRP6,TP53BP1,CARD16,VDAC1,NOD1,CTSB hsa04621 |NOD-like receptor signaling pathway |0.248064259967568 |-1.39406745360862|169 |81 |0.0251007127362876 |3227 |7161 |P2RX7,GABARAPL1,MFN2,IL1B,RIPK2,TBK1,DNM1L,TXN2,XIAP,CTSB,NOD1,CARD16,VDAC1,TP53BP1,NLRP6,MEFV,HSP90AB1,TRAF3,TAB3,TANK,MAPK13,RHOA,TAB1,IFNAR1,ERBIN,TAB2,CXCL8,BIRC2,RIPK1,TRPM7,NOX3,GABARAPL2,JAK1,RBCK1,VDAC3,STAT1,ATG5,ITPR3,CASP4,PLCB1,CAMP,NFKBIB,ANTXR1,NFKBIA,MAPK1,BCL2,ITPR1,BIRC3,TRAF2,RNASEL,TMEM173,PYDC2,MCU,CYBA,JUN,IRF9,NOX1,ITPR2,TRPV2,IKBKG,BCL2L1,TRPM2,ATG16L1,MAPK14,HSP90AA1,CASP8,CXCL2,NLRC4,PLCB4,MAVS,VDAC2,NOD2,TXN,TYK2,PANX1,GSDMD,CARD9,NFKB1,PRKCD,ANTXR2,SUGT1 M00679 |BMP signaling |0.250841167654522 |-1.38293533834079|20 |11 |0.00340873876665634 |3227 |7161 |ACVR1,BMP4,ACVR2A,BMP8A,SMAD9,SMAD4,SMAD1,BMPR2,BMPR1A,BMP6,SMAD5 hsa00532 |Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|0.250841167654522 |-1.38293533834079|20 |11 |0.00340873876665634 |3227 |7161 |CHST3,CHSY1,CHST14,XYLT2,CHST7,CHST15,DSE,B3GAT3,CSGALNACT1,CHST13,B3GALT6 ko00532 |Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|0.250841167654522 |-1.38293533834079|20 |11 |0.00340873876665634 |3227 |7161 |B3GALT6,CSGALNACT1,CHST13,B3GAT3,DSE,CHST15,CHST7,XYLT2,CHST14,CHSY1,CHST3 hsa_M00679|BMP signaling |0.250841167654522 |-1.38293533834079|20 |11 |0.00340873876665634 |3227 |7161 |BMPR1A,BMPR2,BMP6,SMAD5,SMAD1,SMAD9,SMAD4,BMP4,ACVR1,ACVR2A,BMP8A ko05146 |Amoebiasis |0.25562978731673 |-1.36402502447103|94 |46 |0.014254725751472 |3227 |7161 |PRKACA,PTK2,LAMC1,NFKB1,COL4A4,GNAS,ITGB2,IL1R1,PLCB1,LAMA5,RAB7A,PRKCA,RAB5B,GNAL,PLCB4,LAMA3,LAMB1,IL12A,PIK3R3,CXCL8,VCL,LAMB3,ARG1,LAMB4,MUC2,ACTN4,FN1,ITGAM,IL1R2,TGFB3,ACTN1,GNA14,SERPINB6,PIK3R2,RAB5C,PIK3R1,SERPINB1,CD14,IL1B,ADCY1,C8B,SERPINB9,PIK3CB,COL4A5,HSPB1,C8A hsa05146 |Amoebiasis |0.25562978731673 |-1.36402502447103|94 |46 |0.014254725751472 |3227 |7161 |LAMA5,PLCB1,RAB7A,PRKCA,GNAL,RAB5B,LAMA3,PLCB4,PIK3R3,IL12A,LAMB1,VCL,CXCL8,PRKACA,LAMC1,PTK2,COL4A4,NFKB1,GNAS,ITGB2,IL1R1,CD14,IL1B,ADCY1,SERPINB9,C8B,PIK3CB,COL4A5,HSPB1,C8A,ARG1,LAMB4,LAMB3,ACTN4,MUC2,ITGAM,FN1,ACTN1,GNA14,TGFB3,IL1R2,SERPINB6,SERPINB1,PIK3R1,RAB5C,PIK3R2 ko04659 |Th17 cell differentiation |0.259768512411986 |-1.34796438142888|107 |52 |0.0161140378060118 |3227 |7161 |IL17D,CD247,RXRA,IL1B,IL23R,MAPK1,IL23A,HLA-DMB,NFATC3,HLA-DPA1,RORC,MAPK14,IL6R,IL4R,HSP90AB1,FOS,IFNGR1,PPP3CA,IKBKG,HIF1A,STAT3,RUNX1,IL1RAP,JUN,JAK2,IL6ST,TYK2,STAT1,RORA,JAK1,HLA-DOB,RXRB,IRF4,RARA,MAPK13,NFATC2,MTOR,SMAD3,HSP90AA1,IFNGR2,NFKBIA,STAT5A,IL12RB1,STAT5B,STAT6,TGFBR2,NFKB1,NFKBIB,IL1R1,IL21R,AHR,SMAD4 hsa04659 |Th17 cell differentiation |0.259768512411986 |-1.34796438142888|107 |52 |0.0161140378060118 |3227 |7161 |RORC,HLA-DMB,NFATC3,HLA-DPA1,IFNGR1,IL4R,FOS,IL6R,HSP90AB1,MAPK14,IKBKG,STAT3,HIF1A,PPP3CA,IL1RAP,JUN,RUNX1,IL17D,IL1B,RXRA,CD247,IL23R,IL23A,MAPK1,IL12RB1,STAT5B,IFNGR2,NFKBIA,STAT5A,NFKB1,NFKBIB,STAT6,TGFBR2,IL21R,IL1R1,SMAD4,AHR,TYK2,JAK2,IL6ST,RORA,JAK1,STAT1,RXRB,HLA-DOB,NFATC2,MTOR,MAPK13,HSP90AA1,SMAD3,IRF4,RARA