TermID |Term |Enrichment |logP |Genes in Term|Target Genes in Term|Fraction of Targets in Term|Total Target Genes|Total Genes|Gene Symbols :------------|:--------------------------------------------------------------------------------------------------------------------|:-------------------|:----------------|:------------|:-------------------|:--------------------------|:-----------------|:----------|:---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- R-HSA-1430728|Metabolism |7.77465898180891e-21|-46.3034173566322|2158 |1145 |0.251925192519252 |4545 |10287 |AP2A1,NPAS2,CRAT,MIR4761,CPNE6,UPP1,RPL23A,CARM1,ABCC1,AGPAT1,RPL12,HS2ST1,CPOX,FBP1,LYRM4,NFYC,MGLL,ADSS,CA4,ANGPTL8,DECR2,CSAD,IDH3A,CPT1A,SYNJ2,PSMF1,GPAT2,MED26,SORD,LARS,CACNA1E,GSTA1,NDUFA4,SEC24A,ANGPTL3,VLDLR,COQ5,SAR1B,INSIG1,CHSY1,SLC35D2,TBXAS1,FDPS,NFYA,ELOVL3,ITPA,DHODH,NCEH1,CKB,OSBPL6,PLCH1,NDUFS4,UCK1,PIP4K2A,ABCC3,DEGS2,LHX4-AS1,GGPS1,SARDH,TXNRD1,MSMO1,CD36,PPA2,SGMS2,TRIB3,POMC,UBC,ADCY3,ALDH1B1,AACS,GLYATL1,PCCB,PCK2,RPS24,GPC6,ABCB4,ADCY9,STARD4,CYP2S1,PARP14,HPD,PI4KB,NQO2,UQCRC1,HAS3,CA1,SAT1,SCAP,ETNK1,HMGCL,PLA2G4E,SLC6A12,PAPSS2,NUP93,PDHX,ABCD1,LPCAT1,UROD,MED13L,B4GALT5,CHAC2,PLCB1,APRT,ACOT13,TACO1,SH3KBP1,LPIN2,PON2,CIDEC,PSME4,BCAT1,RAB4A,FASN,ALB,PLD1,RPS16,SLC44A1,NAXD,ACOT2,SPR,G6PC2,GBA,SLC19A2,NDUFC1,GAMT,NUDT5,NT5E,RPL9,GUCY2C,HILPDA,NT5M,UGT2B15,NADK,P4HB,SLC27A5,RPL31,GMPR,RPS11,BCKDHB,NDUFS1,TNFAIP8L3,GADL1,NDST2,HSPG2,CSGALNACT1,PLCB4,PDP2,GLYCTK,RPL21,LCLAT1,MED28,PSMA5,RPL5,SLC25A28,COX8A,HAL,GPAM,ACSS3,MAOB,GALT,ACER2,RAB14,B3GAT3,HSD17B4,PNMT,IQGAP1,MED23,ENPP1,ARG1,GPT,NCOR2,GSS,PDK3,SLC22A2,ADSSL1,RRM1,KYAT3,MT1F,MTM1,SGPP1,ACSF2,DBT,COMT,NDUFS5,HMOX1,PHYH,TNFAIP8,PSMB10,SLC25A20,PSMD12,PTGR1,MTMR4,CYP26B1,ACOT7,SLC5A10,GGT5,PAPSS1,CREBBP,PLPP1,HACD2,PSMB3,SLC25A37,MOCS3,SEC23A,OSBPL9,AK2,CYP2C8,GPI,B4GALT2,ACER1,SULT2A1,PSMB11,PUDP,ACADS,HDLBP,IDO2,MOGAT2,TIAM2,MANBA,PNPLA3,IARS,CYP3A43,PLA2G1B,ACLY,MAT2B,GPC5,GGCT,ACOX2,RPL18A,SULT1B1,PSMB5,GPAT4,CYP19A1,COX6A1,NDUFB3,PTGES,RAE1,ACACA,SULT2B1,MED29,PFAS,GALE,PECR,APOB,CYP4F12,WWTR1,RPL24,COX16,SUMF2,ST3GAL6,COQ6,GSTP1,GPC4,HAS2,OCRL,FECH,ANKRD1,NDUFA11,MCEE,COASY,RPS15A,ARNT,DPYS,OTC,HSD17B11,HMMR,AKR1C1,NDUFA8,ETFB,RRM2B,ACSBG1,LIPG,SEC24D,HLCS,MBTPS2,CHST6,G6PC3,COX18,RPS19,KCNG2,ATP5MC1,SLC25A10,ADH4,EPRS,SERINC3,CSNK1G2,GGT1,PIK3C2G,B3GAT2,PRKAG2,ALDH3A2,ALDOB,PYCR1,CAV1,NMNAT1,HIBADH,SPTSSA,GNG4,CACNA1D,NAGLU,ESRRA,UQCRFS1,GLS2,HSD17B2,MLX,PPP2CA,MIR7109,PSMB9,IP6K2,APOA5,CS,MTHFR,ACADVL,DIO1,PIK3C2B,SPHK2,GCH1,ISYNA1,UBA52,RPS5,IYD,NR1H2,GNAI1,NUP43,CTH,AIMP2,MGST2,ESYT3,GNPAT,ATP5PF,SQOR,DCT,ABCG5,CHP1,MOCS1,ABHD14B,ADH6,EPM2A,CHST7,SLC5A9,HSD17B1,NDUFB7,NDUFAB1,TXN,OPLAH,RPL23,PANK3,ACACB,GLRX,PHKB,SLC37A4,GLCE,PSMB1,MTMR14,NDUFS7,CES1,VAPA,CDS2,AASS,MTMR3,GSTA3,NEU1,NUP58,PPCDC,ADI1,FAR1,MIR6848,SLC22A3,AKR1D1,GNG10,DCTD,NDUFB4,LIPM,IMPA2,FA2H,EP300,NUP42,RELN,GYS1,SMS,UQCRC2,CYP2W1,TPK1,NSDHL,LMBRD1,UQCR10,GUCA2B,ACOX3,ST3GAL2,SLC23A2,ACSS1,GC,LDHA,MED9,OAZ2,B3GNT4,PIK3C3,COX7A2L,FLAD1,APOA4,PNPLA2,MED30,SLC25A13,NUDT18,OGDH,NDUFV2,AOX1,UPB1,LDLR,ADH5,GPC1,HS3ST6,CDK8,GM2A,PIKFYVE,PLB1,HDC,ATP5F1C,CYP4F3,PSMB8,XDH,LHPP,SOAT1,ATP5MG,SECISBP2,DMGDH,PCK1,AP2M1,GNB5,CHKA,CERS2,LIPH,KHK,MYLIP,CTPS1,SDC1,RDH11,NRF1,VKORC1L1,CYP27A1,IDH2,DGAT1,TST,AKR1C3,BLVRA,COX6C,FITM2,STAR,PARP8,PHGDH,OSBPL3,PIP5K1A,COQ7,GDPD1,MED4,MTHFD1L,ITPR3,SMARCD3,CCN2,PLPP3,ITPR2,PSMC2,HELZ2,CHST9,ACAT2,GPD2,PIK3CG,SMPD1,UQCRB,PDP1,ABHD10,EEF1E1,INPP5B,PSMB7,ASS1,NT5C3A,MFSD2A,MIR4651,GLO1,NMRAL1,NUDT7,MAN2C1,CYP51A1,CREB3L3,LMF1,GYG1,NUP85,HMGCLL1,ADCY1,GNAS,ALAD,MED27,ALDH1A1,PGS1,CYCS,GLS,N6AMT1,PGD,SGPL1,POR,ACSM2B,PIP5K1B,STS,CALM2,DCTPP1,OAT,HADH,HEXB,MOGAT1,INPP5A,PDXK,D2HGDH,PCSK9,LIPC,COX20,HS6ST1,PNPLA7,ACOT1,GNMT,PI4K2A,AP2A2,SLC25A21,ADK,AGPAT4,KYAT1,ABCG2,SLC25A17,UGP2,ACBD4,SPTLC3,PSMB4,PCYT1A,PAH,TECR,ENPP3,APOC3,SPTLC2,HSD11B2,ITPK1,MVK,ETHE1,MOCOS,MMADHC,PSMD3,HMGCR,DEGS1,B3GALT6,SOAT2,PISD,ENPP6,PIP4P1,CSNK2A2,APOC1,AKR1B15,ACOT12,TNFRSF21,PNPO,THRAP3,CYP2R1,PIK3R2,PPARA,SLC45A3,CYP2A6,ECSIT,ASAH2,PSMA7,SLC35D1,TALDO1,HACD1,GNA14,FABP1,APOC2,CYP26C1,PTGIS,CYP27B1,GNB4,GAPDH,COX14,SULT1C2,ITPKB,FAH,HS3ST5,CIDEA,HSD17B7,MMACHC,SLC27A2,PDK4,TPH2,RPLP2,ACSL6,ADRA2C,ITPKC,MTRR,NUBPL,SLC6A11,SLC44A5,EPHX1,PNPLA4,PPP1CC,PSMA3,INPP5D,CHST13,CHST15,GOT1,MED15,PNP,PSMD14,GPHN,MLXIPL,PANK2,LRP2,RAN,ATP5F1A,AHCYL1,PTS,ESD,RPL32,ECI2,RXRA,CPT2,BAAT,DPEP1,RFK,HAAO,ACSL5,SLC3A2,MARS,CETP,NCOA1,SLC2A4,CYP2C9,CSNK2A1,GPT2,EPHX2,NUP214,LIPA,SARS,ABCA1,A2M,CD38,GCLM,NT5C2,NUP205,SREBF1,NCOA3,FDFT1,UROC1,ACSL4,AP2S1,SLC25A32,GLYATL3,CERS6,ARF1,AMN,ALDH3B1,ARSI,CEPT1,SLC7A5,GCHFR,SUCLG2,PSAP,FDX1,GCSH,GOT2,HSP90AA1,SLC19A3,PI4KA,FXN,CA12,THTPA,HK2,SREBF2,TM7SF2,ALDH4A1,RPS13,GCLC,RPS3A,NUDT19,PCSK6,PCYT1B,MMAB,PLIN1,PSMA1,ELOVL6,SLC26A1,UMPS,CRLS1,SLCO1B3,SCARB1,DDC,STXBP1,GNGT2,SULT1A1,RPS9,MTHFD2,UPP2,GLDC,LPIN3,CNDP2,PEMT,MAT2A,PRKCA,LRP8,TEAD4,GPC3,ATP5F1D,PCTP,RORA,MTMR7,GCK,AZIN2,ACADSB,PLAAT5,ABCG8,AGMAT,ACADL,ALDH2,PPARG,HGD,MDH2,UGT2B7,SLC9A1,UCP3,GSTO2,PIK3R1,PIK3C2A,PLIN2,SPTSSB,PNPLA8,SLC25A15,ADRA2A,GRHPR,NDUFAF6,TAT,B3GNT7,HSP90AB1,CHST14,MGST3,CACNA1A,COX5B,SLC5A5,AHCY,KPNB1,PLEKHA2,SLC25A12,ADIPOR1,CHST5,BLVRB,SERINC2,CACNB3,ACSF3,PYGB,GCKR,ENTPD5,SLC19A1,CA5A,PFKL,CYP2B6,PLTP,AK9,RPL15,MED11,LTA4H,MTHFD2L,PGM2,PGK2,CHST3,AMD1,GPX1,MED8,INPP1,UGT2B10,ACMSD,TBL1X,NUP35,DAB1,PIK3R5,NUDT3,AHR,SLC25A1,NR1D1,SGMS1,NHLRC1,MIR6805,ATP5MC3,ASPG,SLC46A1,TYMP,ARSA,AGT,ACOX1,MIR639,PDSS2,OAZ1,PRSS3,ACSL3,UGT2A3,PRKAR1A,MIR1908,GPD1L,HPGDS,PKM,EXT1,NOSIP,RGL1,GATM,HADHB,KCNS3,ITPR1,SLC27A1,TNFAIP8L1,SPHK1,HNMT,SDC4,AMACR,ENTPD4,ACER3,SCP2,RPL34,CRYL1,PSMD7,GPD1,TK2,DBI,MPC1,PIPOX,GPCPD1,PDPR,ALDH7A1,KYNU,RANBP2,PLA2G6,RPL13A,UGT1A5,SDHB,BTD,AGPAT2,DLST,RPS27,PFKP,UGDH,SLC6A7,APOM,VAC14,DIO2,PGLS,RPL22L1,STX1A,PSAT1,MBOAT1,ENPP2,FPGS,CHIT1,HSD17B14,ACAA1,MAT1A,PSMC4,PITPNB,LDLRAP1,ALDH18A1,PSMA6,CYP24A1,GMPR2,PLEKHA6,COX6B1,AKR1B1,RPE,PPP1CB,PIK3CB,KCNB1,UCK2,LYVE1,HS3ST2,RUFY1,SHMT2,PSMD1,TEAD1,CYB5B,DCK,NDUFAF7,NEU4,BCAT2,ELOVL5,B3GNT2,NEU3,AMDHD1,PANK1,ADCY7,AKR1C2,BPHL,ATP5MC2,ATP5ME,ADPGK,SLC16A3,GLB1,VAMP2,ABHD3,ACSM2A,ASMT,UGT1A4,CHD9,GNG7,CIAO2B,PLA2G4C,QDPR,GCGR,GDA,ACOT11,PIK3R3,VCAN,SEM1,LIPE,DNM2,ADCY4,MAOA,SLC23A1,GYS2,GBE1,MTMR2,SMOX,ALOX15B,ACSM1,PSTK,PLAAT2,ALDOA,TMEM126B,COX5A,FURIN,MED18,LBR,MBTPS1,HMGCS2,APOA2,CYB5A,SELENOI,PPARGC1B,RPIA,LYPLA1,MTF1,ESYT2,GSTO1,ARSG,GLTP,MTR,MAPKAPK2,LRPPRC,MIR6787,MIR3658,PPARD,AKR1A1,CPNE1,CAT,ENOPH1,OSBPL8,PYGL,COQ2,ADH7,DHCR24,OCA2,NDUFB11,SLC25A4,RPL26,SLC2A2,SDC3,SRD5A2,AGPAT3,CDIPT,NR1H3,MMAA,PLCH2,OSBPL2,BPGM,NDUFB9,APOA1,NFS1,AGXT2,GUCA2A,COX4I1,SLC25A19,UBB,NDST1,AOC3,NR1H4,GNAI2,HYAL3,MDH1,CYP2C18,IDI1,PPARGC1A,PPP1R3C,SCLY,ENPP7,ARSB,RPS20,FYN,AGXT,CYP11B2,DHFR,ACSL1,RPL10A,AGPS,SC5D,SUCLG1,RPS21,DGUOK,PSPH,G6PC,SLC2A5,ACSS2,FMOD,DHCR7,ALOX15,PITPNM2,CERK,AIMP1,NDUFAF5,AANAT,MIR6886,ADIPOR2,RPS15,GPX2,PRKAB2,PLA2G2A,HSD17B13,MTAP,ADCY8,GK,MARC2,HADHA,RPLP1,ATP5PO,INPP4A,IVD,CPS1,MED1,UGT2B4,GDPD5,ST3GAL1,ACBD6,RPL19,CA5B,ETNK2,IDH1,ASNS,ALDH1L1,NDUFB6,PHYKPL,FHL2,AFMID,LCAT,SLC2A14,ACSBG2,CYP26A1,NDUFA12,PYCR2,PGM1,FAM120B,CSNK2B,COX11,AP2B1,GPAT3,SULT1E1,ALAS1,AADAT,STAB2,LRP1,CTRC,CERS4,PLCD3,MLYCD,ARL2BP,ENTPD6,ALOX5AP,XYLT2,SDC2,HAGH,RBP4,PDK1,PPM1L,NCOA2,ABCC8,RPL36,RPL13,GPX4,FGF21,ST3GAL4,GUSB,MED20,LPIN1,GSR,CHDH,AASDHPPT,CYP2J2,ETNPPL,PLCG2,KDSR,CYP3A7-CYP3A51P,COQ10B,DUOX2,AK5,PPP2R1B,MIR671,ECI1,SERINC5,CBR4,IP6K3,MARC1,CALM1,ACHE,CHAC1,SEH1L,IMPDH2,LGMN,ASL,CYP8B1,PGK1,PRKACA,SLC2A1,HMBS,BSG,MED13,FADS1,YAP1,NMNAT2,IMPDH1,ARNTL,MGST1,RPS4Y2,RAPGEF4,CYP1A1,ACO2,RPL38,SULT1A2,FDXR,CHPT1,VAPB,SIN3A,LDHAL6B,CYP3A4,NUP188,NUP210,WASL,ASRGL1,DSE,GUK1 R-HSA-556833 |Metabolism of lipids and lipoproteins |4.96103636614772e-13|-28.3319915452238|813 |457 |0.100550055005501 |4545 |10287 |CYP8B1,HSD17B11,HSD11B2,AMACR,AKR1C1,PRKACA,MVK,SCP2,ACER3,SLC27A1,APOC3,TNFAIP8L1,SPHK1,SPTLC2,ANKRD1,MCEE,TECR,ARNT,RGL1,OCRL,PCYT1A,HADHB,SPTLC3,COQ6,ACHE,SUMF2,HPGDS,ACBD4,SLC25A17,GPD1L,WWTR1,CBR4,THRAP3,PIK3R2,PPARA,TNFRSF21,CHPT1,VAPB,SIN3A,MBTPS2,ACOT12,FDXR,PLA2G6,APOC1,ALDH7A1,AKR1B15,PISD,CSNK2A2,ENPP6,LIPG,PIP4P1,ACSBG1,SEC24D,CYP1A1,ARNTL,SOAT2,GPCPD1,GPD1,HMGCR,DEGS1,MED13,FADS1,DBI,YAP1,HADH,FGF21,HEXB,SLC25A1,AHR,PLA2G1B,ACLY,DAB1,GPX4,PIK3R5,STS,TBL1X,PNPLA3,GPX1,PPM1L,MED8,PIP5K1B,NCOA2,SGPL1,ACADS,MED11,LTA4H,MOGAT2,HDLBP,TIAM2,ALOX5AP,SULT2A1,CERS4,MLYCD,MIR1908,PECR,APOB,AGPAT4,MED29,ECI1,PI4K2A,AP2A2,LIPC,KDSR,PTGES,PNPLA7,ACOT1,ACACA,PDSS2,CYP2J2,PCSK9,ETNPPL,ACSL3,CHDH,MIR639,LPIN1,ARSA,GPAT4,CYP19A1,ACOX1,AGT,NR1D1,SGMS1,ACOX2,MED20,MOGAT1,CYP51A1,CREB3L3,TNFAIP8,LMF1,FHL2,NUDT7,PHYH,IDH1,SGPP1,ACSF2,ETNK2,MTM1,MFSD2A,PLEKHA2,KPNB1,ACBD6,MED1,GDPD5,PGS1,PLTP,ACER1,MED27,CYP2C8,AP2B1,SEC23A,GPAT3,OSBPL9,ALAS1,GGT5,HMGCLL1,CREBBP,FAM120B,PLPP1,HACD2,CSNK2B,ACOT7,ACSBG2,LCAT,PTGR1,MTMR4,ACSF3,SLC25A20,RORA,MTMR7,DHCR7,LCLAT1,DGAT1,PCTP,MED28,CYP27A1,TEAD4,NRF1,TNFAIP8L3,PEMT,SC5D,MYLIP,AGPS,AP2M1,DMGDH,SLC27A5,P4HB,LPIN3,CHKA,ACSL1,LIPH,CERS2,SMPD1,INPP4A,PIK3C2A,PLIN2,SPTSSB,PIK3CG,NCOR2,PNPLA8,HELZ2,MED23,GK,HADHA,PIK3R1,GPD2,ACAT2,CCN2,PLPP3,HSD17B13,HSD17B4,MED4,GPX2,ACER2,PRKAB2,RAB14,SMARCD3,PLA2G2A,PIP5K1A,COQ7,PPARG,MIR6886,GDPD1,CERK,PITPNM2,STAR,ACADL,OSBPL3,AKR1C3,PLAAT5,GPAM,ABCG8,FITM2,ALOX15,ACSS3,LDLR,PCSK6,PCYT1B,LPIN2,PON2,APOA1,CIDEC,ACOT13,NUDT19,SH3KBP1,MMAA,OSBPL2,LPCAT1,MED13L,NR1H3,PNPLA2,MED30,SREBF2,ABCD1,CDIPT,TM7SF2,PI4KA,SRD5A2,AGPAT3,APOA4,PLA2G4E,CYP11B2,HILPDA,SOAT1,FYN,CYP4F3,SCARB1,ARSB,GBA,IDI1,PPARGC1A,ENPP7,SLCO1B3,CRLS1,PIKFYVE,ELOVL6,PLB1,NR1H4,PLD1,SLC44A1,ACOT2,PLIN1,CDK8,ALB,FASN,RAB4A,GM2A,FA2H,EP300,MAPKAPK2,RELN,PCCB,ESYT2,MTF1,LIPA,ARSG,ABCA1,A2M,GLTP,SELENOI,PPARGC1B,LIPM,AKR1D1,HMGCS2,EPHX2,AACS,APOA2,LBR,NCOA1,POMC,CYP2C9,CSNK2A1,MIR6848,MBTPS1,FURIN,TRIB3,MED18,SGMS2,FAR1,ALOX15B,NEU1,SARDH,TXNRD1,MSMO1,CETP,CD36,PLAAT2,SCAP,HMGCL,ETNK1,PSAP,DHCR24,FDX1,PIK3C3,COQ2,MED9,AMN,ALDH3B1,OSBPL8,PI4KB,ARSI,CEPT1,CERS6,ACOX3,ARF1,PPARD,CPNE1,ACSL4,AP2S1,SREBF1,NSDHL,NCOA3,FDFT1,ABCB4,STARD4,RAN,ELOVL3,ABCG5,MED15,FDPS,TBXAS1,AKR1C2,NFYA,ESYT3,INSIG1,GNPAT,VLDLR,COQ5,NEU3,SAR1B,SEC24A,ANGPTL3,NEU4,ELOVL5,NR1H2,TEAD1,RUFY1,PPP1CC,INPP5D,MTMR2,GGPS1,LHX4-AS1,ABCC3,CDS2,ACSL5,MTMR3,DEGS2,DPEP1,BAAT,VAPA,PIP4K2A,LIPE,CPT2,MTMR14,ACACB,ACOT11,PIK3R3,ECI2,CHD9,RXRA,PLA2G4C,HSD17B1,NDUFAB1,OSBPL6,NCEH1,GLB1,ABHD3,SPTSSA,MGLL,NFYC,CIDEA,MBOAT1,AGPAT1,PTGIS,CAV1,ALDH3A2,CARM1,ABCC1,VAC14,CRAT,CSNK1G2,HACD1,PIK3C2G,CPNE6,FABP1,APOC2,GGT1,PRKAG2,AP2A1,NPAS2,ASAH2,AGPAT2,PNPLA4,SLC44A5,ACADVL,SPHK2,PIK3C2B,PPP1CB,PIK3CB,PLEKHA6,AKR1B1,MIR7109,SYNJ2,GPAT2,MED26,APOA5,ACSL6,ESRRA,SLC27A2,PITPNB,HSD17B2,CPT1A,LDLRAP1,HSD17B14,ACAA1,ANGPTL8,DECR2,HSD17B7 R-HSA-535734 |Fatty acid, triacylglycerol, and ketone body metabolism |1.16188791340072e-08|-18.2706345502434|253 |156 |0.0343234323432343 |4545 |10287 |NCOA2,MED8,APOA2,AACS,HMGCS2,PPARGC1B,TBL1X,ABCA1,PCCB,ACLY,MTF1,AHR,SLC25A1,EP300,HADH,CD36,SULT2A1,TXNRD1,TIAM2,MOGAT2,ACADS,MED11,MED18,TRIB3,MIR6848,NCOA1,ACOT1,ACACA,MED9,ECI1,MED29,AGPAT4,HMGCL,MIR1908,MED20,MOGAT1,ABCB4,NR1D1,AGT,ACOX1,FDFT1,LPIN1,GPAT4,NCOA3,SREBF1,ACSL4,MIR639,PPARD,ACSL3,ARNT,TECR,MCEE,MMAA,ANKRD1,SLC27A1,ACOT13,LPIN2,APOA1,CBR4,WWTR1,GPD1L,AGPAT3,SREBF2,MED30,HADHB,MED13L,LPCAT1,RGL1,ACOT12,PPARGC1A,SIN3A,TNFRSF21,PPARA,THRAP3,DBI,YAP1,MED13,FADS1,FASN,GPD1,HMGCR,CDK8,ARNTL,ACOT2,NR1H4,CYP1A1,ACSBG1,ELOVL6,TEAD4,CARM1,MED28,PCTP,DGAT1,LCLAT1,AGPAT1,NFYC,RORA,ACSL1,AGPAT2,LPIN3,NPAS2,PRKAG2,FABP1,HACD1,NRF1,CCN2,GPD2,HADHA,GK,MED23,HELZ2,NCOR2,PLIN2,ACADVL,PNPLA4,DECR2,ACSS3,GPAM,CPT1A,ACADL,ESRRA,PPARG,ACSL6,SMARCD3,APOA5,GPAT2,PRKAB2,MED26,MED4,ACSF2,NFYA,MED15,ELOVL3,FHL2,MED1,TEAD1,ACBD6,ELOVL5,HACD2,CPT2,FAM120B,CREBBP,HMGCLL1,ALAS1,GPAT3,ACSL5,MED27,LHX4-AS1,SLC25A20,ACSF3,NDUFAB1,RXRA,ACSBG2,CHD9,ACOT11,ACOT7 R-HSA-4420097|VEGFA-VEGFR2 Pathway |1.46323905503611e-07|-15.7374431416972|330 |192 |0.0422442244224422 |4545 |10287 |AHCYL1,PSMB10,MAPKAP1,IL3,ABI1,NRAS,FGF3,PSMD14,NCK2,AKT3,SHC1,FGF1,PSMB7,CTNNB1,BRAP,RASAL2,SPTBN1,FGG,CDC42,YWHAB,HSPB1,GDNF,PSMD1,PSMA3,AKAP9,CRK,SRC,SOS1,FN1,RICTOR,KSR2,DAB2IP,GFRA4,DUSP16,MAPK13,PSMB3,KLB,MAPKAPK3,PSMB1,RASGRF1,SEM1,JAK2,MIR5004,IRS1,PDGFRB,FGFR1,PSMD12,DUSP10,DUSP7,PSMA5,PAK2,CAV1,SPTAN1,RASA2,DUSP5,CYBA,CYFIP1,FGFR4,CDH5,RASGRP4,GFRA3,PRKCA,CTNNA1,RHOA,NRG1,PTPRA,CSK,DUSP6,PSMA7,UBA52,KBTBD7,RASAL3,PTK2,BRAF,FGF2,PIK3R1,WASF1,KSR1,PIK3CB,JUP,IQGAP1,PAK1,FGF20,ITPR2,PSMC2,PSMF1,ITPR3,PSMB9,FRS3,NF1,PSMA6,PPP2CA,PSMC4,FGFR2,PRR5,ITGB3,PSMD3,PSMD7,JAK1,HBEGF,NCK1,BTC,NEFL,PSME4,PRKACA,PDGFRA,SPHK1,CAMK2D,PDPK1,NRG4,GRB2,ITPR1,KRAS,PPP2R5A,MAP2K1,RASAL1,PSMB4,NCKAP1,KITLG,DOCK1,ARRB1,ERBB3,CALM1,TEK,PDGFA,FGB,MAPK1,RASGRP3,SHB,FYN,ERBB2,PRKCZ,PTK2B,PIK3R2,ELMO1,PSMB8,SPRED1,NRTN,CAMK2G,MTOR,VWF,CAMK2A,VAV3,DUSP1,SPTB,PSMA1,PPP5C,NCF2,UBB,DUSP9,MAPKAPK2,FRS2,MAPK14,EGF,CALM2,WASF2,PAK3,SPRED2,GRIN2A,ABI2,MARK3,RASGRF2,UBC,VCL,RANBP9,SHC3,TRIB3,KL,PXN,PSMB11,PRKCD,KIT,HSP90AA1,VEGFA,PEBP1,FGF9,PPP2R1B,FGA,FGFR3,ROCK2,FGF19,CAMK2B,SYNGAP1,RAF1,RAPGEF2,VAV2,RASA3,FGF10,CYFIP2,PSMB5,BCAR1,ROCK1 R-HSA-194138 |Signaling by VEGF |2.72764451005286e-07|-15.1146572310326|338 |195 |0.0429042904290429 |4545 |10287 |KITLG,NCKAP1,PSMB4,RASAL1,ARRB1,DOCK1,ERBB3,CALM1,PDGFA,TEK,NEFL,NCK1,HBEGF,BTC,JAK1,PSMD7,PSMD3,PDGFRA,PRKACA,PSME4,ITPR1,GRB2,PDPK1,NRG4,CAMK2D,SPHK1,MAP2K1,PPP2R5A,KRAS,MTOR,DUSP1,CAMK2A,VAV3,VWF,PPP5C,SPTB,PSMA1,NRP1,UBB,NCF2,MAPK1,FGB,ELMO1,ERBB2,PIK3R2,PTK2B,PRKCZ,FYN,SHB,RASGRP3,SPRED1,PSMB8,CAMK2G,NRTN,VCL,UBC,RASGRF2,MARK3,ABI2,KL,SHC3,RANBP9,TRIB3,PXN,VEGFD,PRKCD,PSMB11,MAPKAPK2,DUSP9,FRS2,PAK3,WASF2,CALM2,EGF,MAPK14,SPRED2,GRIN2A,RAF1,RAPGEF2,VAV2,FGF10,RASA3,ROCK1,CYFIP2,BCAR1,PSMB5,PEBP1,VEGFA,KIT,HSP90AA1,FGA,PPP2R1B,FGFR3,FGF9,ROCK2,SYNGAP1,CAMK2B,FGF19,FGF1,SHC1,SPTBN1,BRAP,RASAL2,CTNNB1,PSMB7,PSMD1,GDNF,HSPB1,YWHAB,CDC42,FGG,PSMA3,ABI1,PSMB10,AHCYL1,MAPKAP1,IL3,NRAS,NCK2,PSMD14,FGF3,AKT3,IRS1,PDGFRB,DUSP10,NRP2,PSMD12,FGFR1,SOS1,SRC,AKAP9,CRK,FN1,KLB,PSMB3,MAPKAPK3,MAPK13,GFRA4,DUSP16,DAB2IP,KSR2,RICTOR,MIR5004,SEM1,JAK2,RASGRF1,PSMB1,RASGRP4,GFRA3,CDH5,FGFR4,PRKCA,PSMA7,DUSP6,CSK,PTPRA,RHOA,NRG1,CTNNA1,DUSP7,PSMA5,RASA2,PAK2,SPTAN1,CAV1,DUSP5,CYBA,CYFIP1,NF1,FRS3,PSMF1,PSMB9,ITPR3,PPP2CA,PSMA6,PSMC4,PRR5,ITGB3,FGFR2,KBTBD7,UBA52,FGF2,BRAF,PTK2,RASAL3,JUP,IQGAP1,PIK3CB,KSR1,PIK3R1,WASF1,FGF20,ITPR2,PSMC2,PAK1 R-HSA-422475 |Axon guidance |4.29603204127697e-07|-14.6604038353818|549 |299 |0.0657865786578658 |4545 |10287 |SEMA4D,PDLIM7,PIK3CB,KSR1,RPS6KA3,FGF2,PTK2,KBTBD7,UBA52,ACTR3,FGFR2,PSMC4,PPP2CA,PSMA6,SIAH1,NF1,RAP1GAP,FRS3,PSMF1,PSMB9,TRPC3,DUSP5,SEMA6D,RASA2,PAK2,PAK4,ROBO2,DUSP7,HSPA8,CACNA1D,AP2A1,EFNA5,PSMA7,DUSP6,CSK,RHOA,NRG1,FARP2,PTPRA,ARPC1A,SCN1A,MIR5004,SEM1,ABLIM1,ARPC1B,PSMB1,DNM2,TYROBP,ACTR2,GFRA4,ENAH,DAB2IP,SHTN1,SOS1,MYL9,RHOG,SRC,AKAP9,COL9A2,FGFR1,LAMC1,PDGFRB,ABL2,IRS1,PIK3R3,EPHA5,PSMD14,FGF3,RPS6KA1,SHANK3,PFN2,PSMA3,PSMD1,GDNF,FGG,RASAL2,ANK3,SCN2B,SYNGAP1,FGFR3,ST8SIA2,ITGA1,PRNP,YES1,HSP90AA1,KIT,EVL,ROCK1,NRCAM,SCN8A,EFNB1,FGF10,PLXND1,RAPGEF2,AP2S1,CLASP1,SCN9A,TRPC1,EPHB4,RAF1,SPRED2,ITGA2,DOK4,FRS2,DUSP9,DLG1,ARHGEF7,ANK1,DPYSL2,SEMA6A,UBC,MARK3,CSNK2A1,NFASC,NRTN,PSMB8,SPRED1,FYN,SHB,SCN4A,MYH9,ACTG1,NRP1,UBB,PSMA1,SPTB,DUSP1,CAMK2A,VWF,COL6A3,PPP2R5A,CAMK2D,PDGFRA,MYH10,PSME4,HJV,NEFL,GPC1,ARPC5,BTC,NGEF,ACTB,TEK,LIMK2,KITLG,GAP43,FGF20,PSMC2,PAK1,DOK6,IQGAP1,PIK3R1,ARHGEF28,ARHGAP35,BRAF,RASAL3,ALCAM,ITGB3,MYL12B,CLASP2,GRB10,SPTAN1,PTPN11,PSMA5,NTN4,EPHA2,AP2M1,MYH11,ABLIM3,KIF4B,TRIO,RND1,PRKCA,RASGRP4,GFRA3,FGFR4,SCN5A,DCC,JAK2,RASGRF1,CSNK2B,PSMB3,KLB,DUSP16,AP2B1,KSR2,FN1,SCN7A,DUSP10,NRP2,PSMD12,CACNB3,RHOB,RDX,NUMB,NCK2,ANK2,PLXNB1,COL9A3,NRAS,MMP9,LAMB1,PSMB10,IL3,HSP90AB1,YWHAB,CDC42,SEMA7A,RPS6KA2,SPTBN1,BRAP,NTN1,PSMB7,UNC5D,FGF1,SHC1,ARHGEF12,CAMK2B,CDK5R1,FGF19,PITPNA,UNC5A,ROCK2,AP2A2,FGA,PPP2R1B,FGF9,CHL1,PEBP1,VEGFA,ITSN1,PLXNC1,GRB7,PSMB5,LYN,COL4A4,RASA3,VAV2,GRIN2A,GAB2,DPYSL4,PAK3,CALM2,EGF,ROBO1,NEO1,COL4A5,ARPC2,PSMB11,PFN1,GSK3B,SDC2,KL,SHC3,RANBP9,VCL,PLXNA2,RASGRF2,CAMK2G,CAP2,WASL,ERBB2,PIK3R2,RASGRP3,MAPK1,FGB,SIAH2,KALRN,SRGAP1,MYL6,PPP5C,ABL1,CACNB4,EFNA1,CSNK2A2,VAV3,ITGB1,CREB1,MAP2K1,KRAS,GRB2,NRG4,PRKACA,MMP2,NCK1,HBEGF,PSMD7,JAK1,PSMD3,PDGFA,ABLIM2,CALM1,ERBB3,NCSTN,ARRB1,DOCK1,PSMB4,MYH14,RASAL1 R-HSA-400206 |Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |4.34298436389228e-07|-14.6495338977132|127 |84 |0.0184818481848185 |4545 |10287 |PPARA,THRAP3,MED27,ALAS1,SIN3A,TNFRSF21,CPT2,PPARGC1A,FAM120B,CREBBP,CYP1A1,RXRA,CHD9,ARNTL,NR1H4,YAP1,FADS1,MED13,HMGCR,CDK8,FHL2,APOA1,NFYA,SLC27A1,MED15,ARNT,ANKRD1,MED13L,RGL1,SREBF2,MED30,TEAD1,MED1,WWTR1,MIR1908,NCOR2,MED29,PLIN2,MED9,MED23,HELZ2,CCN2,APOA5,SMARCD3,MED26,MED4,PPARG,AGT,CPT1A,ACOX1,FDFT1,NCOA3,ESRRA,SREBF1,MED20,ABCB4,NR1D1,AHR,NFYC,RORA,EP300,ABCA1,MTF1,MED28,PPARGC1B,TBL1X,NCOA2,APOA2,MED8,TEAD4,HMGCS2,CARM1,NCOA1,NRF1,MED18,FABP1,TRIB3,TIAM2,MED11,ACSL1,CD36,NPAS2,TXNRD1,SULT2A1 R-HSA-166520 |Signalling by NGF |5.69100933194923e-07|-14.3792080315655|477 |263 |0.0578657865786579 |4545 |10287 |KRAS,MAP2K1,NRG4,SQSTM1,STAT3,ITPR1,GRB2,ARHGEF10,PRKACA,JAK1,PSMD7,PSMD3,HBEGF,PDGFA,CALM1,ERBB3,ARRB1,NCSTN,RASAL1,PSMB4,CAMK2G,TNRC6B,RASGRP3,ERBB2,PIK3R2,ATF1,MAPK1,FGB,ABR,KALRN,PPP5C,VAV3,CAMK4,MTOR,CREB1,PIP5K1B,GRIN2A,EGF,MCF2L,CALM2,INSR,PRKCI,PSMB11,PRKCD,TIAM2,GSK3B,BCL2L11,NR4A1,KL,RANBP9,SHC3,PHLPP1,RASGRF2,VCL,FGF19,CAMK2B,AP2A2,PPP2R1B,FGA,FGF9,PRKAR1A,PEBP1,PSMB5,ITSN1,RASA3,VAV2,AKT3,KIDINS220,MDM2,NRAS,ITGB3BP,PSMB10,IL3,YWHAB,BRAP,ARHGEF6,PSMB7,NTRK2,RPS6KA2,AGO3,SPTBN1,FGF1,SHC1,ARHGEF12,RASGRF1,ADCY1,JAK2,KSR2,MAG,FGD4,KLB,PSMB3,MAPKAPK3,DUSP16,MAPK13,AP2B1,FN1,CRK,DUSP10,PLEKHG2,PSMD12,TNRC6A,SPTAN1,PSMA5,PTPN11,NET1,AP2M1,TRIO,RPS6KB2,PRKCA,GFRA3,RASGRP4,FGFR4,RAPGEF1,IRAK1,FGF20,ITPR2,PSMC2,CDKN1A,PIK3R1,IQGAP1,ADCY8,RALA,BRAF,RASAL3,FGD2,ITGB3,GSK3A,HDAC2,PIP5K1A,ITPR3,ARHGEF2,DUSP3,RALGDS,PPP2R5A,DNAL4,PDPK1,CAMK2D,PSME4,PDGFRA,PCSK6,TNRC6C,NEFL,BTC,NGEF,NFKB1,ARHGEF16,TEK,ARHGEF3,MEF2A,KITLG,NRTN,PHLPP2,PSMB8,SPRED1,FYN,ARHGEF10L,UBB,SPTB,PSMA1,PIK3AP1,MIR7706,CAMK2A,VWF,DUSP1,AKAP13,SPRED2,MAPK14,PREX1,RALB,FRS2,DUSP9,MAPKAPK2,ARHGEF7,TSC2,FURIN,TRIB3,MARK3,ADCY3,UBC,SYNGAP1,ADAM17,AKT1S1,ARHGEF26,FGFR3,OMG,KIT,ADCY9,FGF10,CASP9,AP2S1,RAPGEF2,AGO2,RAF1,ARHGEF1,ADCY7,RIPK2,FGF3,PSMD14,MAPKAP1,AHCYL1,RPS6KA1,PSMA3,NFKBIA,CD28,FGG,GDNF,PSMD1,RASAL2,MIR718,PSMB1,ADCY4,DNM2,MIR5004,SEM1,DAB2IP,RICTOR,PIP4K2A,GFRA4,SRC,ARHGEF4,ARHGDIA,AKAP9,SOS1,AATF,FGFR1,CRKL,PDGFRB,PIK3R3,IRS1,FOXO3,DUSP5,RASA2,CD80,DUSP7,OBSCN,AP2A1,NRG1,PTPRA,RHOA,PSMA7,DUSP6,CSK,ARHGEF19,KSR1,PIK3CB,PTK2,RPS6KA3,FGF2,RTN4,UBA52,KBTBD7,PRKCE,PRR5,FGFR2,PSMC4,RIT1,PPP2CA,PSMA6,PSMB9,PSMF1,NF1,FRS3 R-HSA-1989781|PPARA activates gene expression |6.01803372457765e-07|-14.3233350688151|124 |82 |0.018041804180418 |4545 |10287 |PPARA,MED27,THRAP3,CPT2,PPARGC1A,FAM120B,CREBBP,ALAS1,TNFRSF21,CYP1A1,RXRA,CHD9,YAP1,MED13,FADS1,HMGCR,CDK8,ARNTL,NR1H4,APOA1,FHL2,ARNT,ANKRD1,NFYA,SLC27A1,MED15,SREBF2,MED30,MED13L,RGL1,MED1,WWTR1,TEAD1,MED29,PLIN2,MIR1908,CCN2,MED9,MED23,HELZ2,PPARG,APOA5,SMARCD3,MED26,MED4,MED20,ABCB4,NR1D1,CPT1A,ACOX1,AGT,FDFT1,ESRRA,NCOA3,SREBF1,ABCA1,MTF1,AHR,NFYC,RORA,EP300,NCOA2,APOA2,MED8,TEAD4,HMGCS2,CARM1,MED28,PPARGC1B,TBL1X,MED18,FABP1,TRIB3,NRF1,NCOA1,CD36,ACSL1,NPAS2,SULT2A1,TXNRD1,TIAM2,MED11 R-HSA-186763 |Downstream signal transduction |1.47374692040871e-06|-13.4277024747264|352 |199 |0.0437843784378438 |4545 |10287 |RAPGEF2,CASP9,STAT1,STAT5A,RAF1,AGO2,BCAR1,PSMB5,ADCY9,GRB7,RASA3,FGF10,FGF9,FGA,PPP2R1B,FGFR3,KIT,PEBP1,PRKAR1A,FGF19,CAMK2B,SYNGAP1,AKT1S1,NR4A1,SHC3,RANBP9,TRIB3,TSC2,KL,ADCY3,RASGRF2,PHLPP1,MARK3,UBC,VCL,PRKCD,PSMB11,GSK3B,FRS2,DUSP9,PIP5K1B,SPRED2,GRIN2A,EGF,INSR,CALM2,VWF,CAMK4,PIK3AP1,CAMK2A,DUSP1,CREB1,MTOR,STAT5B,UBB,PSMA1,SPTB,PPP5C,RASGRP3,FYN,PIK3R2,ERBB2,FGB,MAPK1,NRTN,CAMK2G,TNRC6B,PHLPP2,SPRED1,PSMB8,ARRB1,RASAL1,KITLG,PSMB4,TEK,PDGFA,ERBB3,CALM1,PSME4,PRKACA,TNRC6C,PDGFRA,PSMD3,PSMD7,JAK1,BTC,NCK1,HBEGF,NEFL,KRAS,PPP2R5A,MAP2K1,CAMK2D,PDPK1,NRG4,GRB2,STAT3,ITPR1,PSMA6,PIP5K1A,PPP2CA,PSMB9,PSMF1,ITPR3,FRS3,NF1,GSK3A,FGFR2,PRR5,ITGB3,PRKCE,PSMC4,RASAL3,BRAF,PTK2,FGF2,UBA52,KBTBD7,FGF20,ITPR2,PSMC2,PIK3R1,KSR1,CDKN1A,ADCY8,PIK3CB,IQGAP1,PRKCA,FGFR4,RASGRP4,GFRA3,RAPGEF1,RPS6KB2,PTPRA,NRG1,CSK,DUSP6,PSMA7,PTPN11,PSMA5,DUSP7,CD80,FOXO3,DUSP5,SPTAN1,RASA2,PDGFRB,TNRC6A,PIK3R3,IRS1,FGFR1,PSMD12,DUSP10,CRKL,FN1,CRK,AKAP9,SRC,SOS1,ADCY4,RASGRF1,PSMB1,JAK2,ADCY1,SEM1,MIR5004,RICTOR,PIP4K2A,KSR2,DAB2IP,DUSP16,GFRA4,KLB,PSMB3,PSMB7,RASAL2,BRAP,SPTBN1,AGO3,SHC1,FGF1,PSMA3,CD28,FGG,YWHAB,GDNF,PSMD1,NRAS,PSMB10,MAPKAP1,AHCYL1,IL3,ADCY7,STAT6,AKT3,MDM2,FGF3,PSMD14,NCK2 R-HSA-186797 |Signaling by PDGF |2.4377129432456e-06 |-12.9244502765587|376 |210 |0.0462046204620462 |4545 |10287 |AKT1S1,SYNGAP1,CAMK2B,FGF19,PRKAR1A,PEBP1,KIT,FGA,PPP2R1B,FGFR3,FGF9,FGF10,COL4A4,RASA3,ADCY9,GRB7,BCAR1,PSMB5,AGO2,RAF1,STAT5A,RAPGEF2,STAT1,CASP9,CALM2,INSR,SPP1,EGF,SPRED2,GRIN2A,PIP5K1B,COL4A5,DUSP9,FRS2,GSK3B,PSMB11,PRKCD,UBC,VCL,RASGRF2,MARK3,PHLPP1,ADCY3,KL,TSC2,FURIN,SHC3,TRIB3,RANBP9,NR4A1,PSMB8,SPRED1,TNRC6B,PHLPP2,CAMK2G,NRTN,MAPK1,FGB,PIK3R2,ERBB2,FYN,RASGRP3,PPP5C,PSMA1,SPTB,UBB,STAT5B,MTOR,CREB1,DUSP1,CAMK2A,PIK3AP1,VWF,CAMK4,ITPR1,STAT3,GRB2,PDPK1,NRG4,CAMK2D,COL6A3,MAP2K1,PPP2R5A,KRAS,NEFL,HBEGF,BTC,NCK1,JAK1,PSMD7,PSMD3,PDGFRA,PRKACA,TNRC6C,PSME4,THBS2,CALM1,ERBB3,PDGFA,TEK,PSMB4,KITLG,RASAL1,ARRB1,IQGAP1,ADCY8,PIK3CB,CDKN1A,KSR1,PIK3R1,FGF20,PSMC2,ITPR2,KBTBD7,UBA52,FGF2,BRAF,PTK2,RASAL3,PSMC4,PRR5,PRKCE,ITGB3,GSK3A,FGFR2,NF1,FRS3,PSMB9,ITPR3,PSMF1,PPP2CA,PSMA6,PIP5K1A,THBS1,RASA2,SPTAN1,DUSP5,FOXO3,CD80,DUSP7,PSMA5,PTPN11,PDGFC,PSMA7,CSK,DUSP6,PTPRA,NRG1,RPS6KB2,RAPGEF1,RASGRP4,GFRA3,FGFR4,PTPN12,PRKCA,KLB,PSMB3,GFRA4,DUSP16,DAB2IP,KSR2,RICTOR,PIP4K2A,MIR5004,SEM1,ADCY1,JAK2,RASGRF1,PSMB1,ADCY4,SOS1,SRC,CRK,AKAP9,FN1,CRKL,DUSP10,PSMD12,FGFR1,COL9A2,IRS1,PIK3R3,TNRC6A,PDGFRB,NCK2,PSMD14,FGF3,MDM2,AKT3,ADCY7,STAT6,AHCYL1,PSMB10,IL3,MAPKAP1,COL9A3,NRAS,PSMD1,GDNF,YWHAB,FGG,CD28,PSMA3,FGF1,SHC1,AGO3,SPTBN1,RASAL2,BRAP,PSMB7 R-HSA-2454202|Fc epsilon receptor (FCERI) signaling |2.45028008630772e-06|-12.9193082189999|372 |208 |0.0457645764576458 |4545 |10287 |RASAL1,CUL1,PSMB4,KITLG,TAB1,ARRB1,CALM1,ERBB3,TEK,PDGFA,NFKB1,PSMD3,PSMD7,JAK1,HBEGF,BTC,NEFL,PSME4,TNRC6C,PDGFRA,CAMK2D,PDPK1,NRG4,GRB2,ITPR1,KRAS,PPP2R5A,MAP2K1,NFATC2,CREB1,MTOR,VWF,VAV3,PIK3AP1,CAMK2A,DUSP1,JUN,PSMA1,SPTB,PPP5C,UBB,FGB,MAPK1,MAP2K7,RASGRP3,FYN,ERBB2,PIK3R2,BTRC,TNRC6B,PHLPP2,PSMB8,SPRED1,NRTN,CAMK2G,RASGRF2,MARK3,PHLPP1,UBC,VCL,NR4A1,RANBP9,SHC3,TRIB3,TSC2,KL,IKBKG,GSK3B,PSMB11,MAP3K1,DUSP9,FRS2,FOS,EGF,INSR,CALM2,PIP5K1B,GAB2,RASGRP2,SPRED2,GRIN2A,RAF1,AGO2,CASP9,VAV2,RAPGEF2,RASA3,FGF10,PSMB5,LYN,KIT,PEBP1,FGF9,PPP2R1B,FGFR3,FGA,AKT1S1,FGF19,CAMK2B,PLCG2,SYNGAP1,SHC1,BCL10,FGF1,PSMB7,RASAL2,BRAP,SPTBN1,AGO3,FGG,YWHAB,PSMD1,GDNF,PSMA3,CD28,NFKBIA,PSMB10,AHCYL1,IL3,MAPKAP1,NRAS,MDM2,FGF3,PSMD14,TAB3,AKT3,NFATC3,PIK3R3,TNRC6A,IRS1,PDGFRB,FGFR1,PSMD12,DUSP10,AKAP9,SRC,SOS1,LAT2,SKP1,FN1,PIP4K2A,RICTOR,CARD11,KSR2,DAB2IP,DUSP16,UBE2N,GFRA4,KLB,PSMB3,RASGRF1,PSMB1,PPP3CA,SEM1,JAK2,MIR5004,FGFR4,GFRA3,RASGRP4,UBE2D1,RPS6KB2,PTPRA,NRG1,DUSP6,CSK,PSMA7,CDC34,DUSP7,CD80,PSMA5,PTPN11,PAK2,SPTAN1,RASA2,FOXO3,DUSP5,ITPR3,PSMF1,PSMB9,FRS3,NF1,MALT1,PIP5K1A,PSMA6,PPP2CA,PSMC4,TAB2,FBXW11,UBE2V1,FGFR2,GSK3A,ITGB3,PRR5,UBA52,KBTBD7,RASAL3,PTK2,BRAF,FGF2,PIK3R1,KSR1,CDKN1A,PIK3CB,IQGAP1,PAK1,PSMC2,FGF20,ITPR2 R-HSA-449147 |Signaling by Interleukins |2.78712633447833e-06|-12.790499480575 |525 |283 |0.0622662266226623 |4545 |10287 |HIF1A,STAT1,STAT5A,IL1R1,SAA1,PSMB5,LYN,RASA3,FGF9,IL31RA,PPP2R1B,FGA,PEBP1,VEGFA,FGF19,CAMK2B,CLCF1,SHC3,RANBP9,KL,RASGRF2,CXCL8,VCL,PSMB11,IFNL1,IKBKG,IL22RA1,CSF1,CSF1R,ITGAX,GAB2,GRIN2A,EGF,CALM2,IL7,CCL19,ITGB1,STAT5B,IL23R,PPP5C,RASGRP3,CCR1,PIK3R2,PTK2B,ERBB2,BTRC,FGB,BRWD1,MAPK1,CAMK2G,TAB1,ARRB1,RASAL1,PSMB4,IL34,PDGFA,BCL2L1,CALM1,ERBB3,BCL6,ANXA1,MMP2,PRKACA,TNFRSF1A,CXCL2,PSMD3,JAK1,PSMD7,HBEGF,IL1B,KRAS,MAP2K1,SQSTM1,NRG4,GRB2,STAT3,TAB2,FBXW11,ALOX15,UBE2V1,ITGB3,RASAL3,BRAF,IL7R,IL12A,IL22RA2,IRF4,CCND1,MCL1,FGF20,LGALS9,PSMC2,LCN2,IRAK1,PIK3R1,SMARCA4,CDKN1A,IQGAP1,OPRM1,SOCS1,FGFR4,RASGRP4,GFRA3,RAPGEF1,HIST1H3C,IL10RB,TXLNA,IFNLR1,HIST1H3J,PSMA5,PTPN11,YWHAZ,RORA,JUNB,SPTAN1,IL9R,FSCN1,PSMD12,DUSP10,SKP1,FN1,CRK,IL1A,RASGRF1,JAK2,KSR2,UBE2N,DUSP16,KLB,PSMB3,PSMB7,BRAP,SPTBN1,IL20RB,SHC1,FGF1,LBP,YWHAB,HMOX1,IL6ST,NRAS,IL17RE,IL3,PSMB10,MMP9,STAT6,TOLLIP,ZEB1,RAPGEF2,IL6R,RAF1,FGF10,FGFR3,HSP90AA1,KIT,YES1,IL4R,IL9,LAMA5,IL23A,SYNGAP1,MARK3,UBC,POMC,BCL2,CD36,IL19,PIM1,IL15,FRS2,FOS,DUSP9,SPRED2,VWF,CAMK2A,POU2F1,DUSP1,UBB,NOD2,IL33,PSMA1,SPTB,MAP3K8,FYN,NRTN,IL1RAP,PELI1,PSMB8,SPRED1,CUL1,LIFR,KITLG,TEK,NFKB1,PSME4,PDGFRA,NDN,BTC,NEFL,TYK2,FASLG,BATF,PPP2R5A,IL1RL2,CAMK2D,PSMA6,F13A1,PPP2CA,PSMF1,PSMB9,FRS3,NF1,FGFR2,IL1RN,OSM,PSMC4,PTK2,FGF2,UBA52,IFNL2,IL1R2,MAP3K3,KBTBD7,MAP2K6,KSR1,PIK3CB,SOCS3,CEBPD,ICAM1,NRG1,PTPRA,DUSP6,CSK,PSMA7,STX1A,IL27,HSPA8,DUSP7,CD80,FOXO3,DUSP5,RASA2,STX4,CSF3R,PDGFRB,PIK3R3,IRS1,CCL3L3,IRAK2,FGFR1,RHOU,IL13,OSMR,CRKL,IL12RB1,AKAP9,SRC,SOS1,PSMB1,SEM1,BLNK,MIR5004,MAOA,DAB2IP,GFRA4,RASAL2,ITGAM,MIR718,PSMA3,INPP5D,NOD1,FGG,PSMD1,GDNF,NFKB2,ITGB2,RORC,IL32,CCL20,RIPK2,FGF3,TAB3,PSMD14 R-HSA-187037 |NGF signalling via TRKA from the plasma membrane |3.06621655948181e-06|-12.6950661474318|387 |215 |0.0473047304730473 |4545 |10287 |DUSP1,CAMK2A,PIK3AP1,CAMK4,VWF,CREB1,MTOR,UBB,PPP5C,PSMA1,SPTB,ERBB2,PIK3R2,FYN,RASGRP3,MAPK1,FGB,ATF1,CAMK2G,NRTN,PSMB8,SPRED1,PHLPP2,TNRC6B,ARRB1,MEF2A,KITLG,PSMB4,RASAL1,PDGFA,TEK,ERBB3,CALM1,PDGFRA,PRKACA,TNRC6C,PSME4,NEFL,HBEGF,BTC,JAK1,PSMD7,PSMD3,MAP2K1,PPP2R5A,RALGDS,KRAS,ITPR1,STAT3,GRB2,DNAL4,NRG4,PDPK1,CAMK2D,AP2S1,RAPGEF2,CASP9,AGO2,RAF1,ADCY9,PSMB5,FGF10,RASA3,FGFR3,PPP2R1B,FGA,FGF9,PRKAR1A,PEBP1,KIT,SYNGAP1,CAMK2B,FGF19,AKT1S1,AP2A2,KL,TSC2,RANBP9,SHC3,TRIB3,NR4A1,VCL,UBC,RASGRF2,MARK3,PHLPP1,ADCY3,PSMB11,PRKCD,GSK3B,FRS2,RALB,MAPKAPK2,DUSP9,GRIN2A,SPRED2,PIP5K1B,CALM2,INSR,EGF,MAPK14,PDGFRB,IRS1,PIK3R3,TNRC6A,DUSP10,CRKL,PSMD12,FGFR1,FN1,SOS1,SRC,CRK,AKAP9,MIR5004,JAK2,SEM1,ADCY1,RASGRF1,PSMB1,DNM2,ADCY4,MAPKAPK3,KLB,PSMB3,DUSP16,GFRA4,MAPK13,AP2B1,DAB2IP,KSR2,PIP4K2A,RICTOR,RPS6KA2,AGO3,SPTBN1,RASAL2,BRAP,NTRK2,PSMB7,FGF1,SHC1,CD28,PSMA3,PSMD1,GDNF,YWHAB,FGG,NRAS,RPS6KA1,IL3,PSMB10,MAPKAP1,AHCYL1,AKT3,KIDINS220,ADCY7,PSMD14,FGF3,MDM2,PPP2CA,PSMA6,PIP5K1A,RIT1,NF1,FRS3,DUSP3,PSMB9,ITPR3,PSMF1,PRR5,PRKCE,ITGB3,GSK3A,FGFR2,PSMC4,FGF2,RPS6KA3,PTK2,BRAF,RASAL3,KBTBD7,UBA52,FGF20,PSMC2,ITPR2,IQGAP1,ADCY8,PIK3CB,RALA,CDKN1A,PIK3R1,KSR1,PRKCA,RAPGEF1,GFRA3,RASGRP4,FGFR4,AP2A1,AP2M1,PSMA7,DUSP6,CSK,RHOA,NRG1,PTPRA,RPS6KB2,PSMA5,PTPN11,CD80,DUSP7,DUSP5,FOXO3,RASA2,SPTAN1 R-HSA-177929 |Signaling by EGFR |4.09266766782841e-06|-12.4063135590038|364 |203 |0.0446644664466447 |4545 |10287 |SPRY2,VCL,UBC,ADCY3,MARK3,PHLPP1,RASGRF2,SHC3,RANBP9,TRIB3,TSC2,KL,NR4A1,GSK3B,PXN,ARHGEF7,PRKCD,PSMB11,DUSP9,FRS2,INSR,CALM2,EGF,SPRED2,GRIN2A,PIP5K1B,RAF1,AGO2,CASP9,RAPGEF2,FGF10,RASA3,ADCY9,PSMB5,PEBP1,PRKAR1A,KIT,FGF9,FGA,PPP2R1B,FGFR3,AKT1S1,ADAM17,EPS15L1,CAMK2B,SYNGAP1,FGF19,PSMB4,KITLG,RASAL1,ARRB1,ERBB3,CALM1,TEK,SPRY1,PDGFA,BTC,HBEGF,NEFL,PSMD3,JAK1,PSMD7,PRKACA,TNRC6C,PDGFRA,PSME4,GRB2,ITPR1,CAMK2D,PDPK1,NRG4,SH3KBP1,PPP2R5A,SH3GL1,MAP2K1,KRAS,CREB1,MTOR,STAM,DUSP1,VWF,CAMK4,CAMK2A,PIK3AP1,PPP5C,PSMA1,SPTB,PAG1,UBB,FGB,MAPK1,PIK3R2,ERBB2,RASGRP3,FYN,SPRED1,PSMB8,TNRC6B,PHLPP2,CAMK2G,NRTN,FGFR4,RASGRP4,GFRA3,PTPN12,PRKCA,DUSP6,CSK,PSMA7,RPS6KB2,NRG1,PTPRA,DUSP7,CD80,PSMA5,PTPN11,RASA2,SPTAN1,LRIG1,DUSP5,FOXO3,FRS3,NF1,PSMF1,PSMB9,ITPR3,PSMA6,PIP5K1A,PPP2CA,PSMC4,FGFR2,GSK3A,ITGB3,PRKCE,PRR5,KBTBD7,PTPN3,UBA52,FGF2,RASAL3,PTK2,BRAF,PIK3CB,ADCY8,IQGAP1,PIK3R1,KSR1,CDKN1A,ITPR2,FGF20,PSMC2,SHC1,FGF1,EPS15,SPTBN1,AGO3,PSMB7,RASAL2,BRAP,YWHAB,GDNF,PSMD1,FGG,CDC42,CD28,PSMA3,PSMB10,MAPKAP1,IL3,AHCYL1,NRAS,PSMD14,PTPRK,MDM2,FGF3,AKT3,ADCY7,IRS1,TNRC6A,PIK3R3,PDGFRB,PSMD12,DUSP10,FGFR1,SOS1,AKAP9,SRC,FN1,DUSP16,GFRA4,KLB,PSMB3,PIP4K2A,RICTOR,DAB2IP,KSR2,JAK2,SEM1,ADCY1,MIR5004,ADCY4,PSMB1,RASGRF1 R-HSA-1655829|Regulation of cholesterol biosynthesis by SREBP (SREBF) |4.50201160506672e-06|-12.310986237725 |55 |41 |0.00902090209020902 |4545 |10287 |SMARCD3,ACACB,RXRA,SEC24D,ELOVL6,CHD9,FDFT1,SREBF1,FASN,GPAM,HMGCR,GGPS1,SCAP,PPARA,SEC23A,HELZ2,ACACA,IDI1,MBTPS2,CREBBP,KPNB1,MBTPS1,SAR1B,NCOA1,TM7SF2,SREBF2,SC5D,SEC24A,MED1,DHCR7,NFYC,RAN,CYP51A1,MVK,MTF1,NFYA,TBL1X,FDPS,NCOA2,INSIG1,CARM1 R-HSA-1433557|Signaling by SCF-KIT |5.4332746842018e-06 |-12.1229685331966|337 |189 |0.0415841584158416 |4545 |10287 |PSME4,TNRC6C,PDGFRA,PSMD3,PSMD7,JAK1,BTC,HBEGF,NEFL,KRAS,PPP2R5A,MAP2K1,CAMK2D,NRG4,PDPK1,GRB2,STAT3,ARRB1,RASAL1,KITLG,PSMB4,TEK,PDGFA,ERBB3,CALM1,RASGRP3,FYN,PIK3R2,ERBB2,FGB,MAPK1,NRTN,CAMK2G,TNRC6B,PHLPP2,PSMB8,SPRED1,VWF,CAMK2A,PIK3AP1,DUSP1,CREB1,CHEK1,MTOR,STAT5B,SH2B2,UBB,SPTB,PSMA1,PPP5C,FRS2,DUSP9,PIP5K1B,GAB2,GRIN2A,SPRED2,EGF,INSR,CALM2,NR4A1,SHC3,TRIB3,RANBP9,KL,TSC2,MARK3,RASGRF2,PHLPP1,PTPRU,VCL,UBC,PSMB11,GSK3B,FGF9,PPP2R1B,FGFR3,FGA,KIT,YES1,PEBP1,FGF19,CAMK2B,SYNGAP1,AKT1S1,RAPGEF2,STAT1,CASP9,STAT5A,RAF1,AGO2,LYN,PSMB5,GRB7,RASA3,FGF10,NRAS,MAPKAP1,PSMB10,IL3,MMP9,AKT3,MDM2,FGF3,PSMD14,PSMB7,BRAP,RASAL2,SPTBN1,AGO3,SHC1,FGF1,PSMA3,CD28,FGG,YWHAB,PSMD1,GDNF,FN1,AKAP9,SRC,SOS1,RASGRF1,PSMB1,JAK2,SEM1,MIR5004,RICTOR,PIP4K2A,DAB2IP,KSR2,GFRA4,DUSP16,PSMB3,KLB,PDGFRB,PIK3R3,TNRC6A,IRS1,SOCS6,FGFR1,PSMD12,DUSP10,PTPN11,PSMA5,DUSP7,CD80,FOXO3,DUSP5,GRB10,SPTAN1,RASA2,PRKCA,SOCS1,FGFR4,RASGRP4,GFRA3,SH2B3,CMA1,RPS6KB2,NRG1,PTPRA,CSK,DUSP6,PSMA7,RASAL3,PTK2,BRAF,FGF2,UBA52,KBTBD7,PSMC2,FGF20,PIK3R1,KSR1,CDKN1A,PIK3CB,IQGAP1,PIP5K1A,PSMA6,PPP2CA,PSMB9,PSMF1,FRS3,NF1,FGFR2,GSK3A,PRR5,ITGB3,PSMC4 R-HSA-400253 |Circadian Clock |6.58132237756646e-06|-11.9312748635836|71 |50 |0.011001100110011 |4545 |10287 |TBL1X,CARM1,NCOA2,EP300,RORA,MIR6883,DBP,NRIP1,SIRT1,FBXL3,PER1,RAI1,PPP1CC,NPAS2,MED1,CUL1,UBC,NCOA1,NFIL3,CRY1,PPP1CB,CRTC2,HELZ2,RBM4,PPARGC1A,CREBBP,CRTC1,BHLHE40,UBA52,SERPINE1,SKP1,BTRC,PPARA,NR3C1,SREBF1,CPT1A,ARNTL,F7,KLF15,NR1D1,UBB,CREM,CREB1,CSNK1E,SMARCD3,CHD9,PER2,HIF1A,CRTC3,RXRA R-HSA-5663202|Diseases of signal transduction |1.06791067315849e-05|-11.4472213672949|370 |204 |0.0448844884488449 |4545 |10287 |GAB2,RBPJ,EGF,GTF2F2,TBL1X,FRS2,EP300,PSMB11,BCL2L11,GSK3B,NR4A1,KL,TSC2,MARK3,CUX1,RBP4,UBC,ZC3HAV1,VCL,POLR2E,OS9,FGF19,KREMEN1,SYNGAP1,LMNA,OPN1SW,GTF2F1,ADAM17,AKT1S1,FGFR3,FGA,PPP2R1B,FGF9,DKK4,HSP90AA1,KIT,PEBP1,PSMB5,RASA3,NOTCH1,FGF10,TNKS,STAT1,CASP9,STAT5A,LRRFIP1,RAF1,KRAS,MACF1,MAP2K1,PPP2R5A,NRG4,PDPK1,STAT3,SHH,GRB2,IHH,KIAA0754,PSME4,PDGFRA,POLR2A,AGGF1,PSMD7,PSMD3,HBEGF,BTC,PDGFA,ERBB3,ARRB1,TNKS2,NCSTN,SMAD3,RASAL1,JAG1,PSMB4,KITLG,CUL1,PSMB8,FYN,PIK3R2,ERBB2,MAPK1,BCR,FGB,MPRIP,UBB,CDK8,POLR2D,PSMA1,DKK1,PIK3AP1,VWF,ZMYM2,TENT4A,STAT5B,CPSF6,MTOR,CREB1,FOXO3,RASA2,PTPN11,PSMA5,AGTRAP,TRAK1,CD80,OPN1LW,NRG1,HDAC4,MAML1,HES1,RPS6KB2,PSMA7,CSK,SEL1L,FGFR4,QKI,PSMC2,FGF20,CDKN1A,KSR1,PIK3R1,TGFBR2,IQGAP1,PIK3CB,BRAF,NCOR2,RASAL3,SYVN1,FGF2,UBA52,RLBP1,ITGB3,PRR5,GSK3A,FGFR2,LRP5,PSMC4,HDAC2,HDAC11,PPP2CA,PSMA6,PSMB9,PSMF1,NF1,ERLIN2,AKT3,FGF3,RNF43,MDM2,PSMD14,NRAS,HDAC8,MYO18A,PSMB10,MAPKAP1,NEURL1B,STRA6,FZD5,PSMA3,CD28,FGG,PSMD1,YWHAB,HEYL,AXIN1,ATG7,BRAP,RASAL2,PSMB7,CTNNB1,HDAC5,TCF7L2,TRIM24,FGF1,SHC1,PSMB1,MIR6869,MIR5004,PAPSS1,CREBBP,MIB1,FZD4,JAK2,SEM1,DAB2IP,KSR2,RICTOR,PSMB3,KLB,FN1,SKP1,SRC,SMAD4,AKAP9,SOS1,FGFR1,CNTRL,PSMD12,ERLEC1,PDGFRB,PIK3R3,BAG4,IRS1,KAT2B R-HSA-194315 |Signaling by Rho GTPases |1.08174464590593e-05|-11.4343503143341|427 |232 |0.051045104510451 |4545 |10287 |KIF2B,NCOA2,CALM2,CENPC,WASF2,PREX1,PAK3,HIST1H4H,AURKB,AHCTF1,MCF2L,RHPN2,CDC20,A2M,ARHGAP22,RHOBTB2,NDE1,ARPC2,RHOD,KNL1,PFN1,YWHAG,ARHGAP18,HIST1H2BO,ARHGAP19,ARHGEF7,HIST1H4I,TIAM2,CENPU,PKN2,HIST1H2BH,CENPL,ARHGAP40,ABI2,RASGRF2,DAAM1,KIF5B,KLC4,DIAPH1,ROCK2,ARHGEF26,PPP2R1B,NOX3,PIK3C3,ARAP1,FMNL2,EVL,ITSN1,ROCK1,CYFIP2,TRIP10,NUDC,VAV2,CLASP1,ARHGEF1,PPP2R5A,HIST1H2BL,GRB2,RACGAP1,CENPH,PDPK1,MYH10,ARHGEF10,ARHGAP21,NCK1,ARPC5,RCC2,RHOBTB1,ACTB,NGEF,ARHGEF16,ARHGEF3,CALM1,ARHGAP29,STARD8,SGO2,LIMK2,SEH1L,OCRL,NCKAP1,MYH14,ARHGAP45,RANBP2,RANGAP1,MAPRE1,IQGAP3,NSL1,ARHGAP32,PIK3R2,CENPS,WASL,ARHGAP12,ARHGEF10L,CKAP5,H2AFV,MAPK1,BCR,ACTG1,SRGAP1,INCENP,MYH9,KALRN,MYL6,ARAP3,NCF2,PPP1R12B,ABR,ARHGAP26,ARAP2,ABL1,HIST1H4E,BUB1B,VAV3,MIR7706,ITGB1,AKAP13,ARHGAP15,RHOQ,CYBA,CYFIP1,ARHGAP24,FMNL3,RHOF,IQGAP2,TAOK1,RHOT2,PAK2,RHOH,YWHAZ,HIST1H3J,H2AFJ,HIST1H4K,MAD1L1,CENPF,HIST1H3C,PRC1,OBSCN,RPS27,ARHGAP1,MYH11,NET1,SKA1,STARD13,TRIO,CTNNA1,RHOA,ARHGAP23,ARPC1A,ARHGEF19,KTN1,RHOV,SYDE1,CENPT,CDH1,PAK1,SRF,PPP1CB,RTKN,IQGAP1,WASF1,FMNL1,CTTN,BUB3,RALBP1,ARHGAP35,PTK2,FGD2,HIST1H2BC,MYLK,ACTR3,ROPN1,MRTFA,DLC1,CLIP1,MYL12B,CENPA,DEPDC1B,PPP2CA,CHN2,BUB1,DSN1,RHPN1,ARHGEF2,CLASP2,PLK1,KLC2,KDM4C,ITGB3BP,ABI1,GOPC,PPP1CC,PFN2,HIST1H4B,HIST1H2AE,SPC24,YWHAB,INPP5B,MIR484,CDC42,NDEL1,ARHGEF6,CTNNB1,ARHGEF12,SEC13,NUP43,HIST1H2BJ,CHN1,ARPC1B,LOC101928168,HIST1H4D,MYO9B,KNTC1,ACTR2,FGD4,ARHGAP17,RHOG,SOS1,MYL9,ARHGDIA,ARHGEF4,SRC,H2AFZ,XPO1,YWHAQ,MIR4738,PLEKHG2,NUP85,RHOB,RHOU,FAM13A,NOX1,ARHGAP27 R-HSA-174824 |Lipoprotein metabolism |1.41640802790724e-05|-11.1648013559057|74 |51 |0.0112211221122112 |4545 |10287 |APOA2,SH3KBP1,APOC3,APOA1,ABCA1,CIDEC,A2M,DAB1,LDLR,PRKACA,PCSK6,LIPA,RELN,FGF21,CREB3L3,CETP,AP2M1,AP2A1,P4HB,APOA4,NR1H2,MYLIP,HDLBP,APOC2,FURIN,ANGPTL3,SAR1B,MBTPS1,NR1H3,VLDLR,LIPC,AMN,MBTPS2,SCARB1,AP2A2,AP2B1,FYN,SOAT1,PLTP,APOB,ANGPTL8,NCEH1,ALB,SOAT2,LDLRAP1,LCAT,AP2S1,MIR6886,APOA5,PCSK9,APOC1 R-HSA-5683057|MAPK family signaling cascades |3.35275159883652e-05|-10.3031440834883|290 |162 |0.0356435643564356 |4545 |10287 |CAMK2G,NRTN,PSMB8,SPRED1,TNRC6B,ERBB2,FYN,RASGRP3,MAPK1,FGB,DNAJB1,CCND3,KALRN,UBB,PPP5C,SPTB,PSMA1,JUN,DUSP1,CAMK2A,VWF,MAP2K1,PPP2R5A,TYK2,KRAS,GRB2,NRG4,CAMK2D,PDGFRA,TNRC6C,PRKACA,PSME4,NEFL,BTC,HBEGF,PSMD7,JAK1,PSMD3,PDGFA,TEK,ERBB3,CALM1,ARRB1,PSMB4,KITLG,CDC42EP2,RASAL1,SYNGAP1,CAMK2B,FGF19,FGA,FGFR3,PPP2R1B,FGF9,PEBP1,KIT,PSMB5,NCOA3,FGF10,RASA3,RAPGEF2,AGO2,RAF1,IL6R,GRIN2A,SPRED2,PAK3,CALM2,EGF,FRS2,DUSP9,PSMB11,KL,RANBP9,SHC3,UBC,VCL,MARK3,RASGRF2,MIR5004,JAK2,SEM1,PSMB1,RASGRF1,KLB,PSMB3,DUSP16,GFRA4,DAB2IP,KSR2,FN1,SOS1,SRC,AKAP9,XPO1,DUSP10,PSMD12,FGFR1,PDGFRB,IRS1,TNRC6A,PSMD14,FGF3,NRAS,IL6ST,IL3,PSMB10,PSMA3,GDNF,PSMD1,HSPB1,YWHAB,CDC42,FGG,AGO3,SPTBN1,RASAL2,BRAP,PSMB7,FGF1,SHC1,FGF20,PSMC2,PAK1,IQGAP1,ETV4,KSR1,FGF2,BRAF,PTK2,RASAL3,KBTBD7,UBA52,ITGB3,FGFR2,PSMC4,PPP2CA,IGF2BP1,PSMA6,NF1,FRS3,PSMF1,PSMB9,DUSP5,FOXO3,RASA2,PAK2,SPTAN1,PTPN11,PSMA5,DUSP7,PSMA7,DUSP6,CSK,PTPRA,NRG1,CDC14B,MAPK6,GFRA3,RASGRP4,MAPK4,FGFR4 R-HSA-5628897|TP53 Regulates Metabolic Genes |5.88849497787847e-05|-9.73992502154054|82 |54 |0.0118811881188119 |4545 |10287 |GPI,CYCS,GLS,COX6B1,RHEB,COX20,LAMTOR4,PRKAB1,COX11,TNRC6B,COX18,SESN3,RRM2B,SESN1,MTOR,COX6A1,PRKAA1,TNRC6A,PRKAB2,GPX2,AGO2,COX4I1,COX6C,YWHAQ,SESN2,GSR,TXN,GLS2,RPTOR,TNRC6C,YWHAZ,RRAGC,COX14,RRAGB,LRPPRC,COX8A,AKT3,PRDX2,TACO1,DDIT4,TSC2,AGO3,PRDX1,COX5B,PRKAG2,PRKAG1,PRDX5,TXNRD1,YWHAG,COX7A2L,YWHAB,COX16,NDUFA4,COX5A R-HSA-74751 |Insulin receptor signalling cascade |6.89885724216629e-05|-9.58156968416039|297 |164 |0.0360836083608361 |4545 |10287 |EGF,INSR,CALM2,SPRED2,EEF2K,GRIN2A,DUSP9,FRS2,PSMB11,MARK3,RASGRF2,UBC,VCL,PRKAG1,TRIB3,RANBP9,SHC3,KL,TSC2,AKT1S1,STRADA,FGF19,CAMK2B,SYNGAP1,KIT,PEBP1,PIK3C3,FGF9,FGFR3,PPP2R1B,FGA,RASA3,CAB39,FGF10,PSMB5,RAF1,RAPGEF2,CAMK2D,PDPK1,NRG4,EIF4B,GRB2,KRAS,PPP2R5A,MAP2K1,PSMD3,RRAGB,JAK1,PSMD7,BTC,HBEGF,NEFL,PSME4,PDGFRA,CALM1,ERBB3,TEK,PDGFA,RASAL1,PSMB4,KITLG,ARRB1,PSMB8,SPRED1,RHEB,NRTN,CAMK2G,FGB,MAPK1,RASGRP3,FYN,PIK3R2,ERBB2,SPTB,PSMA1,PPP5C,UBB,PRKAA1,MTOR,VWF,CAMK2A,DUSP1,SPTAN1,RASA2,GRB10,DUSP5,DUSP7,RRAGC,PSMA5,PTPN11,RPTOR,NRG1,PTPRA,PDE3B,DUSP6,CSK,PSMA7,FGFR4,GFRA3,RASGRP4,PRKAG2,PIK3R1,KSR1,LAMTOR4,PIK3CB,IQGAP1,FGF20,TLR9,PSMC2,UBA52,KBTBD7,RASAL3,PTK2,BRAF,FGF2,PSMC4,FGFR2,ITGB3,PRKAB2,PSMB9,PSMF1,FRS3,NF1,PSMA6,PPP2CA,FGF3,PSMD14,PSMB10,IL3,NRAS,FGG,YWHAB,PSMD1,GDNF,PSMA3,EIF4EBP1,SHC1,FGF1,PSMB7,BRAP,RASAL2,SPTBN1,KSR2,DAB2IP,DUSP16,GFRA4,PSMB3,KLB,PRKAB1,EIF4E,PSMB1,RASGRF1,SEM1,JAK2,MIR5004,AKAP9,SRC,SOS1,FN1,FGFR1,PSMD12,DUSP10,IRS1,PDGFRB R-HSA-512988 |Interleukin-3, 5 and GM-CSF signaling |7.28176426632657e-05|-9.52755228784664|271 |151 |0.0332233223322332 |4545 |10287 |SOS1,AKAP9,CRK,SRC,FN1,GFRA4,DUSP16,PSMB3,KLB,KSR2,DAB2IP,JAK2,SEM1,BLNK,MIR5004,RASGRF1,PSMB1,IRS1,PIK3R3,PDGFRB,PSMD12,DUSP10,CRKL,FGFR1,IL3,PSMB10,NRAS,PSMD14,FGF3,SHC1,FGF1,SPTBN1,PSMB7,BRAP,RASAL2,YWHAB,GDNF,PSMD1,FGG,PSMA3,INPP5D,KBTBD7,UBA52,FGF2,RASAL3,PTK2,BRAF,PIK3CB,IQGAP1,PIK3R1,KSR1,PSMC2,FGF20,FRS3,NF1,PSMF1,PSMB9,PSMA6,PPP2CA,PSMC4,FGFR2,ITGB3,DUSP7,YWHAZ,PTPN11,PSMA5,RASA2,SPTAN1,DUSP5,RAPGEF1,FGFR4,GFRA3,RASGRP4,DUSP6,CSK,PSMA7,PTPRA,NRG1,FGB,MAPK1,PIK3R2,ERBB2,RASGRP3,FYN,SPRED1,PSMB8,CAMK2G,NRTN,STAT5B,DUSP1,VWF,CAMK2A,PPP5C,SPTB,PSMA1,UBB,BTC,HBEGF,NEFL,PSMD3,JAK1,PSMD7,PRKACA,PDGFRA,PSME4,GRB2,CAMK2D,NRG4,PPP2R5A,MAP2K1,KRAS,PSMB4,KITLG,RASAL1,ARRB1,ERBB3,CALM1,TEK,PDGFA,PEBP1,KIT,YES1,FGF9,PPP2R1B,FGFR3,FGA,CAMK2B,SYNGAP1,FGF19,RAF1,STAT5A,RAPGEF2,FGF10,RASA3,LYN,PSMB5,DUSP9,FRS2,CALM2,EGF,GRIN2A,SPRED2,GAB2,UBC,VCL,RASGRF2,MARK3,RANBP9,SHC3,KL,PSMB11 R-HSA-983705 |Signaling by the B Cell Receptor (BCR) |7.35485390806441e-05|-9.51756497405571|229 |130 |0.0286028602860286 |4545 |10287 |PSMA1,UBB,MTOR,CREB1,PIK3AP1,PSMB8,PHLPP2,TNRC6B,MAPK1,PIK3R2,ERBB2,BTRC,RASGRP3,FYN,CALM1,ERBB3,NFKB1,PDGFA,PSMB4,KITLG,CUL1,GRB2,ITPR1,PDPK1,SH3KBP1,NRG4,PPP2R5A,KRAS,NCK1,HBEGF,BTC,PSMD3,PSMD7,TNRC6C,PDGFRA,PSME4,FGF10,LYN,PSMB5,TRPC1,AGO2,CBLB,CASP9,AKT1S1,NFKBIB,PLCG2,FGF19,KIT,ORAI1,FGF9,PPP2R1B,FGFR3,GSK3B,IKBKG,PSMB11,REL,UBC,PHLPP1,TRIB3,TSC2,KL,NR4A1,CALM2,INSR,EGF,PIP5K1B,MIR4687,FRS2,PSMD12,FGFR1,IRS1,TNRC6A,PIK3R3,PDGFRB,PSMB3,KLB,RICTOR,CARD11,PIP4K2A,BLNK,SEM1,PSMB1,SOS1,SRC,SKP1,PSMD1,CD28,NFKBIA,PSMA3,SHC1,BCL10,FGF1,AGO3,PSMB7,PSMD14,MDM2,FGF3,AKT3,PSMB10,MAPKAP1,AHCYL1,NRAS,PSMC4,GSK3A,FGFR2,PRR5,FBXW11,MALT1,PSMB9,PSMF1,ITPR3,PIP5K1A,PSMA6,PPP2CA,PIK3CB,PIK3R1,CDKN1A,FGF20,ITPR2,PSMC2,UBA52,FGF2,PSMA7,RPS6KB2,NRG1,FGFR4,FOXO3,CD80,PSMA5,PTPN11 R-HSA-2262752|Cellular responses to stress |7.51114577285158e-05|-9.49653744453942|451 |239 |0.0525852585258526 |4545 |10287 |CAT,HIF1A,NUDT2,SUZ12,NUP205,PSMB5,RPA3,CDKN2B,EP400,GSR,PIK3C3,H1F0,POT1,HSP90AA1,UVRAG,TFDP2,CBX8,VEGFA,RAE1,CAMK2B,CHMP2A,TERF2,PHC2,AKT1S1,AMBRA1,PRKAG1,PRDX6,TSC2,HIST1H2BH,CXCL8,UBC,HSPA9,HSPA12B,PSMB11,NUP58,ATG4C,TXNRD1,HIST1H4I,GSK3B,ANAPC15,HIST1H2BO,FOS,PHC1,NUP42,MAPKAPK2,EP300,MAP3K5,ATG4B,HIST1H1C,GPX1,UBN1,UBE2C,MAPK14,NUP35,MAP1LC3B,ANAPC7,NUP214,HIST1H4H,CAMK2A,HIST1H4E,EPAS1,PRKAA1,MTOR,NCF2,UBB,MAP1LC3A,HSPA6,ATG13,JUN,PSMA1,GPX5,MAP2K7,NUP188,NUP210,CDKN2D,DNAJB1,H2AFV,MAPK1,MAP4K4,SCMH1,RHEB,CABIN1,HSPA7,CAMK2G,GPX8,RANBP2,TNRC6B,ATM,PSMB8,SEH1L,PRDX1,EHMT1,GSTP1,GPX3,HSPA4L,PSMB4,VHL,ATG10,NFKB1,PRDX5,SOD1,EED,NUP93,HSPA1B,CHMP4B,PSME4,TNRC6C,RRAGB,PSMD3,PSMD7,NBN,RPA1,ARNT,CAMK2D,HIST1H1A,HIST1H2BL,HIRA,LIMD1,STAT3,CCNA2,PSMA6,GPX2,PSMB9,PSMF1,PRKAB2,CEBPB,PHC3,GPX7,E2F3,WIPI1,PSMC4,ANAPC4,EEF1A1,RPS6KA3,UBA52,HIST1H2BC,SOD2,CDK4,HSPH1,LMNB1,RPA2,PSMC2,MAP2K6,CDKN1A,LAMTOR4,BAG3,PRKAG2,UBE2D1,ETS2,RPS19BP1,CHMP3,HIST1H3C,P4HB,UBE2D3,GABARAPL2,PSMA7,RRAGC,GABARAPL1,HIST1H3J,PSMA5,RPTOR,TXNRD2,ATR,HSPA12A,E2F2,HSPA5,TXN2,HSPA8,EGLN3,H2AFJ,HIST1H4K,UBE2E1,TNIK,CYBA,CBX4,FZR1,HSPA1A,EGLN2,PRDX2,CHMP4A,CITED2,PRDX3,TNRC6A,BAG4,MDM4,ATG14,MIR4738,ATG5,TXN,PSMD12,NUP85,MTMR3,H2AFZ,IL1A,CYCS,MTMR14,HIST1H4D,CHMP6,DNAJC2,PSMB1,SEM1,CREBBP,CDK6,ELOC,MAP2K3,MAPKAPK3,PRKAB1,PSMB3,ACD,PSMB7,ATG7,TINF2,DNAJB6,AGO3,RPS6KA2,AQP8,NUP43,CHMP4C,HIST1H2BJ,CCNE1,HIST1H4B,NOX5,PSMA3,HIST1H2AE,GPX6,KDM6B,HSPA13,HSP90AB1,PSMD1,SIRT1,ID1,ATG16L1,PSMB10,RBBP7,RPS6KA1,CHMP2B,MDM2,PSMD14,CUL2 R-HSA-74752 |Signaling by Insulin receptor |8.03333085665561e-05|-9.42932622144191|322 |176 |0.0387238723872387 |4545 |10287 |KBTBD7,UBA52,FGF2,ATP6V1C2,PTK2,BRAF,RASAL3,IQGAP1,ATP6V0D2,LAMTOR4,PIK3CB,ATP6V1G2,PIK3R1,KSR1,FGF20,TLR9,PSMC2,NF1,FRS3,PRKAB2,PSMF1,PSMB9,PPP2CA,PSMA6,PSMC4,ITGB3,FGFR2,DUSP7,RPTOR,PSMA5,PTPN11,RRAGC,RASA2,SPTAN1,DUSP5,GRB10,ATP6V0E1,GFRA3,RASGRP4,FGFR4,PRKAG2,PSMA7,DUSP6,CSK,PDE3B,NRG1,PTPRA,SOS1,SRC,AKAP9,FN1,KLB,PRKAB1,PSMB3,DUSP16,GFRA4,KSR2,DAB2IP,MIR5004,SEM1,JAK2,PSMB1,RASGRF1,EIF4E,IRS1,PDGFRB,DUSP10,PSMD12,FGFR1,PSMB10,IL3,NRAS,PSMD14,FGF3,FGF1,SHC1,EIF4EBP1,SPTBN1,BRAP,RASAL2,PSMB7,GDNF,PSMD1,YWHAB,FGG,PSMA3,PEBP1,KIT,FGFR3,PPP2R1B,FGA,FGF9,ATP6V0A1,PIK3C3,ATP6V1C1,STRADA,AKT1S1,SYNGAP1,CAMK2B,ATP6V1D,FGF19,RAF1,RAPGEF2,FGF10,CAB39,RASA3,PSMB5,DUSP9,FRS2,CALM2,INSR,EGF,ATP6V0D1,EEF2K,SPRED2,GRIN2A,UBC,VCL,RASGRF2,MARK3,KL,TSC2,TRIB3,SHC3,RANBP9,PRKAG1,PSMB11,ATP6V1G1,MAPK1,FGB,ATP6V0A4,ATP6V1E2,PIK3R2,ERBB2,FYN,RASGRP3,ATP6V0C,SPRED1,PSMB8,CAMK2G,NRTN,RHEB,MTOR,PRKAA1,DUSP1,CAMK2A,VWF,PPP5C,PSMA1,SPTB,UBB,NEFL,HBEGF,BTC,JAK1,PSMD7,RRAGB,PSMD3,PDGFRA,PSME4,GRB2,NRG4,PDPK1,EIF4B,CAMK2D,MAP2K1,PPP2R5A,KRAS,PSMB4,KITLG,RASAL1,ARRB1,ERBB3,CALM1,PDGFA,TEK R-HSA-2428928|IRS-related events triggered by IGF1R |8.71769027672218e-05|-9.34757113865801|298 |164 |0.0360836083608361 |4545 |10287 |DUSP10,PSMD12,FGFR1,PDGFRB,IRS1,MIR5004,SEM1,JAK2,PSMB1,RASGRF1,EIF4E,KLB,PSMB3,PRKAB1,DUSP16,GFRA4,KSR2,DAB2IP,FN1,SOS1,SRC,AKAP9,PSMA3,GDNF,PSMD1,YWHAB,FGG,SPTBN1,BRAP,RASAL2,PSMB7,FGF1,SHC1,EIF4EBP1,PSMD14,FGF3,NRAS,PSMB10,IL3,ITGB3,FGFR2,PSMC4,PPP2CA,PSMA6,NF1,FRS3,PSMB9,PSMF1,PRKAB2,TLR9,FGF20,PSMC2,IQGAP1,PIK3CB,LAMTOR4,PIK3R1,KSR1,FGF2,PTK2,BRAF,RASAL3,KBTBD7,UBA52,PSMA7,PDE3B,CSK,DUSP6,PTPRA,NRG1,PRKAG2,RASGRP4,GFRA3,FGFR4,IGF1,DUSP5,RASA2,SPTAN1,RPTOR,PTPN11,PSMA5,RRAGC,DUSP7,UBB,PPP5C,SPTB,PSMA1,DUSP1,CAMK2A,VWF,MTOR,PRKAA1,CAMK2G,NRTN,RHEB,PSMB8,SPRED1,ERBB2,PIK3R2,FYN,RASGRP3,MAPK1,FGB,PDGFA,TEK,ERBB3,CALM1,ARRB1,PSMB4,KITLG,RASAL1,MAP2K1,PPP2R5A,KRAS,GRB2,PDPK1,NRG4,EIF4B,CAMK2D,PDGFRA,PSME4,NEFL,BTC,HBEGF,PSMD7,JAK1,RRAGB,PSMD3,IGF2,PSMB5,FGF10,CAB39,RASA3,RAPGEF2,RAF1,SYNGAP1,CAMK2B,FGF19,STRADA,AKT1S1,FGFR3,PPP2R1B,FGA,FGF9,PIK3C3,PEBP1,KIT,PSMB11,KL,TSC2,RANBP9,SHC3,TRIB3,PRKAG1,UBC,VCL,MARK3,RASGRF2,SPRED2,EEF2K,GRIN2A,CALM2,EGF,FRS2,DUSP9 R-HSA-2428924|IGF1R signaling cascade |8.71769027672218e-05|-9.34757113865801|298 |164 |0.0360836083608361 |4545 |10287 |DUSP7,RPTOR,PSMA5,PTPN11,RRAGC,RASA2,SPTAN1,DUSP5,GFRA3,RASGRP4,FGFR4,IGF1,PRKAG2,PSMA7,CSK,PDE3B,DUSP6,NRG1,PTPRA,KBTBD7,UBA52,FGF2,BRAF,PTK2,RASAL3,IQGAP1,PIK3CB,LAMTOR4,PIK3R1,KSR1,FGF20,TLR9,PSMC2,NF1,FRS3,PSMF1,PSMB9,PRKAB2,PPP2CA,PSMA6,PSMC4,ITGB3,FGFR2,IL3,PSMB10,NRAS,PSMD14,FGF3,FGF1,SHC1,EIF4EBP1,SPTBN1,RASAL2,BRAP,PSMB7,PSMD1,GDNF,YWHAB,FGG,PSMA3,SOS1,SRC,AKAP9,FN1,PRKAB1,PSMB3,KLB,DUSP16,GFRA4,DAB2IP,KSR2,MIR5004,SEM1,JAK2,PSMB1,RASGRF1,EIF4E,IRS1,PDGFRB,DUSP10,PSMD12,FGFR1,DUSP9,FRS2,CALM2,EGF,SPRED2,GRIN2A,EEF2K,UBC,VCL,RASGRF2,MARK3,TSC2,KL,RANBP9,TRIB3,SHC3,PRKAG1,PSMB11,PEBP1,KIT,FGFR3,FGA,PPP2R1B,FGF9,PIK3C3,STRADA,AKT1S1,SYNGAP1,CAMK2B,FGF19,RAF1,RAPGEF2,CAB39,FGF10,RASA3,IGF2,PSMB5,NEFL,HBEGF,BTC,PSMD7,JAK1,RRAGB,PSMD3,PDGFRA,PSME4,GRB2,PDPK1,NRG4,EIF4B,CAMK2D,MAP2K1,PPP2R5A,KRAS,KITLG,PSMB4,RASAL1,ARRB1,CALM1,ERBB3,PDGFA,TEK,MAPK1,FGB,PIK3R2,ERBB2,FYN,RASGRP3,PSMB8,SPRED1,CAMK2G,NRTN,RHEB,MTOR,PRKAA1,DUSP1,CAMK2A,VWF,PPP5C,SPTB,PSMA1,UBB R-HSA-112399 |IRS-mediated signalling |8.82071073364074e-05|-9.33582301615265|294 |162 |0.0356435643564356 |4545 |10287 |NRG4,PDPK1,EIF4B,CAMK2D,GRB2,KRAS,MAP2K1,PPP2R5A,PSMD7,JAK1,PSMD3,RRAGB,NEFL,HBEGF,BTC,PSME4,PDGFRA,ERBB3,CALM1,PDGFA,TEK,RASAL1,KITLG,PSMB4,ARRB1,SPRED1,PSMB8,NRTN,RHEB,CAMK2G,MAPK1,FGB,FYN,RASGRP3,PIK3R2,ERBB2,SPTB,PSMA1,PPP5C,UBB,PRKAA1,MTOR,CAMK2A,VWF,DUSP1,EGF,CALM2,SPRED2,EEF2K,GRIN2A,DUSP9,FRS2,PSMB11,MARK3,RASGRF2,UBC,VCL,PRKAG1,KL,TSC2,TRIB3,SHC3,RANBP9,STRADA,AKT1S1,FGF19,SYNGAP1,CAMK2B,KIT,PEBP1,PIK3C3,PPP2R1B,FGA,FGFR3,FGF9,RASA3,FGF10,CAB39,PSMB5,RAF1,RAPGEF2,FGF3,PSMD14,IL3,PSMB10,NRAS,FGG,GDNF,PSMD1,YWHAB,PSMA3,EIF4EBP1,FGF1,SHC1,RASAL2,BRAP,PSMB7,SPTBN1,DAB2IP,KSR2,KLB,PSMB3,PRKAB1,GFRA4,DUSP16,PSMB1,RASGRF1,EIF4E,MIR5004,SEM1,JAK2,SRC,AKAP9,SOS1,FN1,FGFR1,DUSP10,PSMD12,IRS1,PDGFRB,SPTAN1,RASA2,DUSP5,DUSP7,PTPN11,PSMA5,RRAGC,RPTOR,PTPRA,NRG1,PSMA7,DUSP6,CSK,PDE3B,RASGRP4,GFRA3,FGFR4,PRKAG2,PIK3R1,KSR1,IQGAP1,PIK3CB,LAMTOR4,FGF20,TLR9,PSMC2,UBA52,KBTBD7,BRAF,PTK2,RASAL3,FGF2,PSMC4,ITGB3,FGFR2,PRKAB2,PSMF1,PSMB9,NF1,FRS3,PPP2CA,PSMA6 R-HSA-166016 |Toll Like Receptor 4 (TLR4) Cascade |8.94337232074646e-05|-9.32201272982755|126 |77 |0.0169416941694169 |4545 |10287 |BIRC2,FOS,SARM1,PTPN11,MAPKAPK2,DUSP7,CASP8,MAP3K1,MAPK14,UBE2D1,PTPN4,SOCS1,UBC,CD180,UBE2D3,CD36,ECSIT,HMGB1,CD14,DUSP6,IKBKG,AGER,PPP2R1B,RPS6KA3,UBA52,NFKBIB,PLCG2,TANK,IRAK1,LY86,MAP2K6,PPP2CA,DUSP3,SAA1,UBE2V1,TAB2,FBXW11,TBK1,TLR6,RPS6KA1,NFKB2,ITGB2,MAP2K1,RIPK2,TAB3,RPS6KA2,TAB1,MEF2A,CUL1,ITGAM,MIR718,NOD1,LBP,NFKBIA,NFKB1,RIPK1,SKP1,BTRC,BIRC3,MAP2K7,MAP3K8,MAPK1,ATF1,DNM2,UBE2N,MAP2K3,MAPKAPK3,PELI1,CREB1,TRAF3,IRAK2,NOD2,UBB,LY96,BPI,APP,JUN R-HSA-2426168|Activation of gene expression by SREBF (SREBP) |9.27175997904753e-05|-9.28595224591069|42 |31 |0.00682068206820682 |4545 |10287 |NFYA,HELZ2,TBL1X,FDPS,NCOA2,ACACA,CARM1,CREBBP,IDI1,DHCR7,GGPS1,CYP51A1,NFYC,MVK,PPARA,MTF1,FDFT1,SREBF1,MED1,HMGCR,FASN,GPAM,SMARCD3,NCOA1,ACACB,SREBF2,RXRA,TM7SF2,CHD9,SC5D,ELOVL6 R-HSA-5218921|VEGFR2 mediated cell proliferation |9.51543387594518e-05|-9.26001036610826|258 |144 |0.0316831683168317 |4545 |10287 |VWF,CAMK2A,DUSP1,SPTB,PSMA1,PPP5C,UBB,FGB,MAPK1,RASGRP3,FYN,ERBB2,PRKCZ,SPRED1,PSMB8,NRTN,CAMK2G,RASAL1,KITLG,PSMB4,ARRB1,CALM1,ERBB3,TEK,PDGFA,PSMD3,PSMD7,JAK1,HBEGF,BTC,NEFL,PSME4,PDGFRA,SPHK1,CAMK2D,PDPK1,NRG4,GRB2,ITPR1,KRAS,PPP2R5A,MAP2K1,RAF1,RAPGEF2,RASA3,FGF10,PSMB5,KIT,PEBP1,VEGFA,FGF9,FGFR3,PPP2R1B,FGA,FGF19,CAMK2B,SYNGAP1,MARK3,RASGRF2,VCL,UBC,SHC3,RANBP9,KL,PRKCD,PSMB11,DUSP9,FRS2,EGF,CALM2,GRIN2A,SPRED2,IRS1,PDGFRB,FGFR1,PSMD12,DUSP10,AKAP9,SRC,SOS1,FN1,KSR2,DAB2IP,DUSP16,GFRA4,KLB,PSMB3,RASGRF1,PSMB1,JAK2,SEM1,MIR5004,SHC1,FGF1,PSMB7,RASAL2,BRAP,SPTBN1,FGG,YWHAB,PSMD1,GDNF,PSMA3,AHCYL1,PSMB10,IL3,NRAS,FGF3,PSMD14,PSMF1,PSMB9,ITPR3,FRS3,NF1,PSMA6,PPP2CA,PSMC4,FGFR2,ITGB3,UBA52,KBTBD7,RASAL3,BRAF,PTK2,FGF2,KSR1,IQGAP1,FGF20,PSMC2,ITPR2,FGFR4,GFRA3,RASGRP4,PRKCA,PTPRA,NRG1,CSK,DUSP6,PSMA7,DUSP7,PSMA5,SPTAN1,RASA2,DUSP5 R-HSA-2424491|DAP12 signaling |0.000107140487726017|-9.14136961529094|356 |192 |0.0422442244224422 |4545 |10287 |PRKCE,ITGB3,PRR5,FGFR2,GSK3A,PSMC4,PPP2CA,PSMA6,PIP5K1A,NF1,FRS3,PSMB9,PSMF1,ITPR3,FGF20,PSMC2,ITPR2,IQGAP1,PIK3CB,ADCY8,CDKN1A,KSR1,PIK3R1,FGF2,PTK2,BRAF,RASAL3,KBTBD7,UBA52,PSMA7,DUSP6,CSK,NRG1,PTPRA,RPS6KB2,PRKCA,RASGRP4,GFRA3,FGFR4,DUSP5,FOXO3,RASA2,SPTAN1,PTPN11,PSMA5,CD80,DUSP7,DUSP10,PSMD12,FGFR1,PDGFRB,IRS1,TNRC6A,PIK3R3,MIR5004,ADCY1,SEM1,JAK2,PSMB1,RASGRF1,ADCY4,PSMB3,TYROBP,KLB,DUSP16,GFRA4,DAB2IP,KSR2,RICTOR,PIP4K2A,FN1,SOS1,SRC,AKAP9,CD28,PSMA3,GDNF,PSMD1,YWHAB,FGG,AGO3,SPTBN1,RASAL2,BRAP,PSMB7,FGF1,SHC1,AKT3,ADCY7,PSMD14,FGF3,MDM2,NRAS,IL3,PSMB10,AHCYL1,MAPKAP1,ADCY9,PSMB5,FGF10,RASA3,VAV2,RAPGEF2,CASP9,AGO2,RAF1,SYNGAP1,PLCG2,CAMK2B,FGF19,AKT1S1,FGA,PPP2R1B,FGFR3,FGF9,PRKAR1A,PEBP1,KIT,PRKCD,PSMB11,GSK3B,TSC2,KL,RANBP9,SHC3,TRIB3,NR4A1,VCL,UBC,PHLPP1,MARK3,RASGRF2,ADCY3,SPRED2,GRIN2A,PIP5K1B,CALM2,INSR,EGF,FRS2,DUSP9,UBB,PPP5C,PSMA1,SPTB,DUSP1,VAV3,CAMK2A,PIK3AP1,CAMK4,VWF,MTOR,CREB1,CAMK2G,NRTN,KLRK1,SPRED1,PSMB8,PHLPP2,TNRC6B,ERBB2,PIK3R2,FYN,RASGRP3,MAPK1,FGB,PDGFA,TEK,CALM1,ERBB3,ARRB1,KITLG,PSMB4,RASAL1,MAP2K1,PPP2R5A,KRAS,ITPR1,GRB2,PDPK1,NRG4,CAMK2D,PDGFRA,TNRC6C,PRKACA,PSME4,NEFL,BTC,HBEGF,JAK1,PSMD7,PSMD3 R-HSA-168249 |Innate Immune System |0.000107771750974775|-9.13549498415733|1285 |630 |0.138613861386139 |4545 |10287 |ORM2,HEBP2,CD80,SERPINB1,DUSP7,HSPA8,CYBA,DUSP5,IQGAP2,RASA2,PAK2,CDC34,ECSIT,CD68,SURF4,PSMA7,DUSP6,CSK,RHOA,DDX58,FGF2,CAPN1,ACTR3,TANK,TRPM2,LY86,UNC13D,DNAJC5,GSN,MALT1,NF1,SERPINB6,SLPI,FRS3,PSMF1,PRKCE,CHGA,SLC27A2,BPIFA2,RPS6KA1,ITGB2,MAPKAP1,AHCYL1,NFKB2,RAB3D,PSMD14,PNP,FGF3,ISG15,MBL2,CCT2,CTNNB1,ITGAM,NFKBIA,PROS1,PSMA3,CCR6,EPX,FGG,CGAS,ATP11B,CRISPLD2,RAB7A,RHOG,AKAP9,BST2,MIR5004,PPP3CA,MYO9B,ACTR2,DAB2IP,CARD11,PIP4K2A,PDGFRB,IRS1,HGSNAT,FGFR1,ATG5,FOS,ATP11A,NIT2,CFD,ILF2,C3,TSC2,TRIB3,SERPINA3,BCL2,UBC,MARK3,ADCY3,ABI2,VAT1,HMGB1,CD36,DDX3X,PSAP,IST1,KIT,YES1,HSP90AA1,ALDH3B1,DIAPH1,DDX41,RAB10,DEFB132,AGO2,GPR84,ADCY9,TLR5,CYFIP2,FGF10,ATAD3B,ORM1,ANPEP,TNRC6C,DEFB116,PSME4,PLPP5,ARPC5,CD247,DEFB112,APRT,CKAP4,MEF2A,SCAMP1,CFB,LPCAT1,CUL1,NFKB1,MVP,TEK,OTUD5,RAB37,MAP3K8,MAP2K7,ATP6V0C,NFASC,ARHGAP45,STBD1,DUSP1,CAMK2A,ACTG1,NOD2,PLD1,PSMA1,CRCP,JUN,PTPN11,PSMA5,DEFB1,PLAC8,CYFIP1,C4BPA,SPTAN1,SOCS1,PTPN4,PRKCA,RASGRP4,UBE2D3,TRIM25,EEA1,ARG1,DSG1,RASAL3,PSEN1,SERPINA1,CTSH,FGF20,REG3G,IQGAP1,ATP6V0D2,ATP6V1G2,PIK3R1,TMEM63A,DSN1,DTX4,CNPY3,DUSP3,RAB14,ITGB3,CLU,GSK3A,TAB2,TAX1BP1,XRCC6,COMMD9,TLR6,POLR3H,ITCH,DHX58,PSMB10,TOLLIP,C1S,ELANE,STAT6,VAMP8,CTSD,AGO3,RPS6KA2,SLCO4C1,FGF1,SHC1,IRF1,KPNB1,LBP,RIPK1,YWHAB,CYSTM1,HSP90AB1,CDC42,LAMP2,SKP1,GPI,CASP4,PFKL,CRK,CREBBP,RASGRF1,KLB,MAPKAPK3,PSMB3,UBE2N,ITGAL,DUSP16,KSR2,PYGB,NFATC3,KCMF1,PSMD12,ACLY,ARPC2,TMBIM1,GRIN2A,MEFV,ADGRE3,CDK13,GAB2,PAK3,INSR,EGF,QSOX1,ATP6V0D1,PRDX6,SHC3,TRAF2,MANBA,PGM2,VCL,RAB5C,DNAJC3,PSMB11,UBE2K,CD53,GSK3B,LTA4H,FGA,ADGRG3,FGF9,AP1M1,ATP6V0A1,ATP6V1C1,PRKAR1A,PEBP1,PTPRJ,FCGR3A,APOB,CAMK2B,FGF19,LRRFIP1,PRSS3,PSMB5,CAB39,ARSA,RASA3,TUBB,NCK1,PSMD7,CALML5,KRAS,ITPR1,NLRC4,GSTP1,ARRB1,DOCK1,TAB1,NCKAP1,RASAL1,PDGFA,RNF135,ERBB3,PKM,ERBB2,RASGRP3,MAPK1,CSTB,ATF1,CAMK2G,KLRK1,PLA2G6,MUC3A,PECAM1,TNRC6B,C2,VAV3,CAMK4,MTOR,NCF2,PPP5C,FAF2,IRF2,CAMP,CHIT1,FOXO3,ATP6V0E1,PRKDC,RAP2B,FTH1,UBE2D1,ARPC1A,NOS1,CST3,IGF2R,AGPAT2,PTPRA,NRG1,RPS6KA3,PTK2,RAB27A,KBTBD7,UBA52,TLR9,CREG1,SVIP,PIK3CB,KSR1,WASF1,MAP2K6,PPP2CA,PSMA6,PSMB9,PRR5,FGFR2,ACAA1,PSMC4,ABI1,CARD9,RIPK2,ADCY7,DSC1,TAB3,RASAL2,POLR3GL,ACTR1B,MIR718,CTSB,P2RX7,NOD1,CD28,GDNF,PSMD1,PCBP2,STK10,TREM1,LAT2,KCNAB2,SOS1,SRC,PRDX4,STOM,ARPC1B,SEM1,POLR1D,PSMB1,ADCY4,DNM2,TYROBP,GFRA4,MAP2K3,VAPA,RICTOR,OSTF1,ADA2,ANXA2,PIK3R3,GLB1,IRAK2,LY96,TXN,APP,C4BPB,FRS2,MYO1C,SARM1,EP300,DYNC1LI1,MAPKAPK2,MAP3K1,DUSP9,SPRED2,MIR6843,RASGRP2,WASF2,VTN,MAPK14,PGRMC1,POLR2E,MIR6848,MAP3K14,NEU1,LRG1,ALDOA,SIRPA,C5AR1,FGFR3,PIK3C3,SYNGAP1,APEH,AKT1S1,PYGL,S100A9,CPNE1,CAT,CASP9,RAPGEF2,CASP10,DSP,METTL7A,RAF1,ROCK1,ADAM8,CD55,SNAP29,PDGFRA,C8A,POLR3E,NEFL,BTC,CAND1,PPP2R5A,PANX1,PDPK1,CAMK2D,XRCC5,POLR3A,KITLG,ACTB,MUC5B,HSPA1B,ATP6V1E2,ELMO1,CTSL,FYN,BIRC3,RNASE7,ATP6V0A4,NRTN,PSMB8,SPRED1,ARSB,GSDMD,PHLPP2,PELI1,PIK3AP1,VWF,OLFM4,BPIFB6,MYH9,S100A11,GM2A,UBB,SLC11A1,SPTB,YPEL5,CAPZA2,SLC2A5,PRCP,RHOF,RNASE2,DGAT1,HSPA1A,CTSC,MUC2,CD180,GFRA3,FGFR4,PLEKHO2,GNLY,ANO6,RPS6KB2,AGER,EEF1A1,ATP6V1C2,CEACAM8,BRAF,ICAM3,TXNDC5,IRAK1,LCN2,ITPR2,PSMC2,PAK1,GGH,JUP,ADCY8,CDKN1A,PIP5K1A,NFAM1,ITPR3,PLA2G2A,BPIFB1,UBE2V1,FBXW11,EEF2,FTL,TOM1,NRAS,MMP9,IL3,LGALS3,AKT3,GZMM,S100P,IDH1,LAMP1,MDM2,SPTBN1,ATG7,BRAP,PSMB7,BCL10,HP,QPCT,ALAD,C8B,FN1,C5,RAB5B,AHSG,JAK2,ADCY1,CSNK2B,BRI3,MAPK13,ICAM2,TRAF3,TNRC6A,PGM1,GYG1,DUSP10,CXCR1,GOLGA7,SUGT1,BPIFB2,BIRC2,CASP8,COTL1,POLR3B,HEXB,ITGAX,PIP5K1B,CALM2,KL,RANBP9,NR4A1,TMC6,FCGR2A,RAB31,RASGRF2,PHLPP1,PRKCD,RAB6A,C1R,CD14,IKBKG,PPP2R1B,PPIA,ATP6AP2,MUC13,PLCG2,NFKBIB,ATP6V1D,AP2A2,FGR,VAV2,SAA1,MIF,LYN,GUSB,TBK1,PDXK,TRIM56,COLEC11,PRKACA,DYNC1H1,HBEGF,IL1B,JAK1,PSMD3,MAP2K1,GRB2,MAVS,NRG4,NCSTN,PSMB4,ARL8A,IMPDH2,LGMN,BCL2L1,CMTM6,TSPAN14,CALM1,BTRC,PIK3R2,WASL,ATP6V1G1,FGB,RNASE8,CTSZ,SYNGR1,CREB1,NFATC2,TMEM173,HVCN1,DEGS1,HSPA6,BPI,IMPDH1,ABL1,MGST1 R-HSA-2404192|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |0.000109717287308319|-9.1176036159672 |299 |164 |0.0360836083608361 |4545 |10287 |PSMB10,IL3,NRAS,FGF3,PSMD14,EIF4EBP1,FGF1,SHC1,RASAL2,BRAP,PSMB7,SPTBN1,FGG,PSMD1,GDNF,YWHAB,PSMA3,SRC,AKAP9,SOS1,FN1,KSR2,DAB2IP,PSMB3,KLB,PRKAB1,GFRA4,DUSP16,PSMB1,RASGRF1,EIF4E,MIR5004,SEM1,JAK2,IRS1,PDGFRB,FGFR1,DUSP10,PSMD12,DUSP7,PSMA5,PTPN11,RRAGC,RPTOR,SPTAN1,RASA2,DUSP5,GFRA3,RASGRP4,IGF1,FGFR4,PRKAG2,NRG1,PTPRA,PSMA7,PDE3B,DUSP6,CSK,UBA52,KBTBD7,BRAF,PTK2,RASAL3,FGF2,KSR1,PIK3R1,IQGAP1,PIK3CB,LAMTOR4,TLR9,PSMC2,FGF20,PRKAB2,PSMB9,PSMF1,NF1,FRS3,PPP2CA,PSMA6,PSMC4,ITGB3,FGFR2,JAK1,PSMD7,RRAGB,PSMD3,NEFL,BTC,HBEGF,PSME4,PDGFRA,PDPK1,NRG4,EIF4B,CAMK2D,GRB2,KRAS,MAP2K1,PPP2R5A,RASAL1,PSMB4,KITLG,ARRB1,ERBB3,CALM1,PDGFA,TEK,MAPK1,FGB,FYN,RASGRP3,PIK3R2,ERBB2,PSMB8,SPRED1,NRTN,RHEB,CAMK2G,PRKAA1,MTOR,CAMK2A,VWF,DUSP1,SPTB,PSMA1,PPP5C,UBB,DUSP9,FRS2,EGF,CALM2,SPRED2,EEF2K,GRIN2A,MARK3,RASGRF2,UBC,VCL,PRKAG1,TSC2,KL,TRIB3,SHC3,RANBP9,PSMB11,KIT,PEBP1,PIK3C3,PPP2R1B,FGFR3,FGA,FGF9,STRADA,AKT1S1,FGF19,SYNGAP1,CAMK2B,RAF1,RAPGEF2,RASA3,FGF10,CAB39,PSMB5,IGF2 R-HSA-1168372|Downstream signaling events of B Cell Receptor (BCR) |0.000119664178688525|-9.03082124926393|197 |113 |0.0248624862486249 |4545 |10287 |FGF10,PSMC4,PRR5,FGFR2,GSK3A,PSMB5,FBXW11,MALT1,AGO2,PSMF1,PSMB9,PPP2CA,PSMA6,PIP5K1A,CASP9,AKT1S1,PIK3CB,CDKN1A,PIK3R1,PSMC2,FGF20,NFKBIB,FGF19,UBA52,KIT,FGF2,FGFR3,PPP2R1B,FGF9,PSMA7,GSK3B,NRG1,RPS6KB2,IKBKG,PSMB11,REL,UBC,PHLPP1,FGFR4,TSC2,KL,TRIB3,NR4A1,INSR,EGF,FOXO3,PIP5K1B,CD80,FRS2,PSMA5,PTPN11,PSMD12,PSMA1,FGFR1,UBB,IRS1,MTOR,CREB1,TNRC6A,PIK3R3,PDGFRB,PIK3AP1,PSMB3,KLB,PSMB8,CARD11,RICTOR,PIP4K2A,PHLPP2,TNRC6B,SEM1,PSMB1,MAPK1,SRC,SKP1,BTRC,PIK3R2,ERBB2,FYN,RASGRP3,PSMD1,ERBB3,NFKBIA,CD28,NFKB1,PSMA3,PDGFA,FGF1,BCL10,PSMB4,CUL1,KITLG,AGO3,PSMB7,PSMD14,GRB2,PDPK1,FGF3,NRG4,MDM2,PPP2R5A,AKT3,KRAS,HBEGF,BTC,PSMD7,MAPKAP1,PSMB10,PSMD3,PDGFRA,TNRC6C,NRAS,PSME4 R-HSA-187687 |Signalling to ERKs |0.000120942739589052|-9.02019335091131|263 |146 |0.0321232123212321 |4545 |10287 |PEBP1,KIT,PPP2R1B,FGFR3,FGA,FGF9,SYNGAP1,CAMK2B,FGF19,RAF1,RAPGEF2,FGF10,RASA3,PSMB5,MAPKAPK2,DUSP9,FRS2,RALB,CALM2,EGF,MAPK14,GRIN2A,SPRED2,VCL,UBC,MARK3,RASGRF2,KL,RANBP9,SHC3,PSMB11,MAPK1,FGB,ERBB2,FYN,RASGRP3,SPRED1,PSMB8,CAMK2G,NRTN,DUSP1,CAMK2A,VWF,PPP5C,SPTB,PSMA1,UBB,NEFL,HBEGF,BTC,JAK1,PSMD7,PSMD3,PDGFRA,PSME4,GRB2,NRG4,CAMK2D,MAP2K1,PPP2R5A,RALGDS,KRAS,PSMB4,KITLG,RASAL1,ARRB1,ERBB3,CALM1,PDGFA,TEK,KBTBD7,UBA52,FGF2,PTK2,BRAF,RASAL3,IQGAP1,RALA,KSR1,FGF20,PSMC2,NF1,FRS3,PSMF1,PSMB9,PPP2CA,PSMA6,RIT1,PSMC4,ITGB3,FGFR2,DUSP7,PSMA5,RASA2,SPTAN1,DUSP5,RAPGEF1,RASGRP4,GFRA3,FGFR4,PSMA7,CSK,DUSP6,NRG1,PTPRA,SOS1,SRC,CRK,AKAP9,FN1,KLB,MAPKAPK3,PSMB3,MAPK13,GFRA4,DUSP16,DAB2IP,KSR2,MIR5004,JAK2,SEM1,PSMB1,RASGRF1,IRS1,PDGFRB,CRKL,DUSP10,PSMD12,FGFR1,PSMB10,IL3,NRAS,PSMD14,FGF3,KIDINS220,FGF1,SHC1,SPTBN1,BRAP,RASAL2,PSMB7,PSMD1,GDNF,YWHAB,FGG,PSMA3 R-HSA-2586552|Signaling by Leptin |0.000123008540705358|-9.00325676837354|253 |141 |0.031023102310231 |4545 |10287 |DUSP1,CAMK2A,VWF,STAT5B,UBB,LEP,PPP5C,PSMA1,SPTB,ERBB2,FYN,RASGRP3,MAPK1,FGB,CAMK2G,NRTN,PSMB8,SPRED1,ARRB1,KITLG,PSMB4,RASAL1,PDGFA,TEK,CALM1,ERBB3,PDGFRA,PSME4,NEFL,BTC,HBEGF,JAK1,PSMD7,PSMD3,MAP2K1,PPP2R5A,KRAS,STAT3,GRB2,NRG4,CAMK2D,STAT5A,RAPGEF2,RAF1,PSMB5,FGF10,RASA3,FGFR3,FGA,PPP2R1B,FGF9,PEBP1,KIT,SYNGAP1,CAMK2B,FGF19,LEPR,KL,RANBP9,SHC3,UBC,VCL,RASGRF2,MARK3,PSMB11,FRS2,DUSP9,GRIN2A,SPRED2,CALM2,EGF,PDGFRB,IRS1,DUSP10,PSMD12,FGFR1,FN1,SOS1,SRC,AKAP9,MIR5004,SEM1,JAK2,RASGRF1,PSMB1,KLB,PSMB3,DUSP16,GFRA4,DAB2IP,KSR2,SPTBN1,RASAL2,BRAP,PSMB7,FGF1,SHC1,PSMA3,GDNF,PSMD1,YWHAB,FGG,NRAS,IL3,PSMB10,PSMD14,FGF3,PPP2CA,PSMA6,NF1,FRS3,PSMB9,PSMF1,ITGB3,FGFR2,PSMC4,FGF2,PTK2,BRAF,RASAL3,KBTBD7,UBA52,FGF20,PSMC2,IQGAP1,KSR1,SOCS3,GFRA3,RASGRP4,FGFR4,PSMA7,CSK,DUSP6,NRG1,PTPRA,PSMA5,PTPN11,DUSP7,DUSP5,RASA2,SPTAN1 R-HSA-3700989|Transcriptional Regulation by TP53 |0.000124752972770349|-8.98917499379414|367 |197 |0.0433443344334433 |4545 |10287 |RBBP7,MAPKAP1,CNOT6L,MIR1257,DDIT4,MDM2,CNOT8,TAF11,AKT3,TBP,GATAD2B,CCNE1,ELL,TAF1,AGO3,COX5B,YWHAB,CNOT1,NDUFA4,JMY,CYCS,GLS,PRMT1,GPI,COX11,PRKAB1,SETD9,BRCA1,ELOC,PIP4K2A,RICTOR,BARD1,CREBBP,EXO1,CSNK2B,NUAK1,SESN1,TNKS1BP1,TNRC6A,CCNH,RABGGTA,TXN,CCNT2,YWHAQ,RMI2,MDM4,COX14,COX8A,CNOT10,BANP,ATR,YWHAZ,RPTOR,BRD1,RRAGC,ATRIP,PRDX2,PHF20,KMT5A,CARM1,SMYD2,NELFCD,PRKAG2,BBC3,TPX2,CRADD,TNFRSF10D,TOP3A,USP7,ELOA,UBA52,FAS,SGK1,LAMTOR4,USP2,CDKN1A,MAP2K6,MDC1,COX6B1,RPA2,RAD51D,NELFE,PRKAB2,GPX2,POU4F2,PPP2CA,SESN3,NELFA,PPP1R13B,CHEK2,HDAC2,CCNA2,CNOT7,TAF4,GLS2,HIPK2,RFC2,PRR5,HIPK1,RAD9B,COX6C,RPA1,NBN,RRAGB,POLR2A,PMS2,TNRC6C,TAF12,STEAP3,TACO1,PDPK1,SUPT4H1,BNIP3L,NLRC4,EHMT1,MEAF6,PRDX1,COX16,BCL6,GADD45A,PRDX5,COX7A2L,TOPBP1,BCL2L14,PERP,KAT6A,IGFBP3,RBL1,MTA2,ATM,COX18,TNRC6B,RHEB,MTOR,CHEK1,ING5,PRKAA1,TAF3,RRM2B,CNOT9,CSNK2A2,PIP4P1,TNFRSF10C,JUN,POLR2D,COX4I1,UBB,EP300,LRPPRC,BRD7,TNFRSF10B,AIFM2,FOS,MIR3191,GATAD2A,GTF2F2,MAPK14,AURKB,CDK13,UBC,POLR2E,PLK3,CSNK2A1,TSC2,CNOT2,RBL2,PRKAG1,MLH1,DNA2,RFFL,COX5A,TXNRD1,YWHAG,TFDP2,TP73,PPP2R1B,TAF6,GTF2F1,CDK5R1,RFC3,NDRG1,COX20,CNOT6,CASP10,COX6A1,AGO2,FANCC,MSH2,RBBP8,ARID3A,GSR,SESN2,RHNO1,CNOT11,PCNA,RPA3,PRDM1 R-HSA-446652 |Interleukin-1 signaling |0.000139417667396927|-8.87803632880967|46 |33 |0.00726072607260726 |4545 |10287 |MIR718,CUL1,UBC,TAB1,IKBKG,NFKB1,NOD1,IL1B,SQSTM1,TAB3,RIPK2,TOLLIP,MAP2K1,IL1R1,IL1RN,UBB,TAB2,NOD2,FBXW11,IRAK2,UBE2V1,UBA52,MAP3K3,IL1R2,IL1A,MAP3K8,SKP1,BTRC,MAP2K6,PELI1,UBE2N,IRAK1,IL1RAP R-HSA-196854 |Metabolism of vitamins and cofactors |0.000145832387711831|-8.83305262511747|174 |101 |0.0222222222222222 |4545 |10287 |PANK3,ACACB,SLC19A1,PLB1,NMNAT2,NAXD,MMAB,FASN,SLC25A19,BTD,DHFR,CYP2R1,SLC23A1,PNPO,LRP1,NT5E,RFK,MOCS3,HLCS,SLC19A2,PANK1,LGMN,THTPA,GPC4,SDC3,FLAD1,APOA4,SHMT2,SLC19A3,MOCOS,MOCS1,MMADHC,GPC1,LRP2,SDC4,AKR1C1,ALDH1L1,CYP8B1,LDLR,PANK2,APOA1,SLC2A1,NFS1,ENPP3,AOX1,GPHN,APOC3,MMAA,COASY,MTHFD1L,SLC25A32,AASDHPPT,PRSS3,PARP14,LMBRD1,MIR6886,CYP24A1,PDXK,PARP8,MMACHC,SLC46A1,GPC6,AKR1C3,TPK1,APOB,GC,MTHFR,MTRR,GSTO2,ENPP1,AMN,SLC23A2,ACACA,RBP4,VKORC1L1,HSPG2,SDC1,APOM,LRP8,RDH11,APOC2,MTHFD2L,SDC2,NADK,PPCDC,CTRC,MTHFD2,CD38,ENPP2,MTR,FPGS,NMNAT1,GSTO1,PCCB,GPC5,CYB5A,PTGIS,CYP27B1,GPC3,ABCC1,APOA2 R-HSA-8853659|RET signaling |0.000151514147036816|-8.7948315575935 |270 |149 |0.0327832783278328 |4545 |10287 |RASA3,FGF10,PSMB5,GRB7,RAF1,RAPGEF2,FGF19,CAMK2B,SYNGAP1,KIT,PEBP1,FGF9,PPP2R1B,FGFR3,FGA,PSMB11,MARK3,RASGRF2,VCL,UBC,SHC3,RANBP9,KL,EGF,CALM2,GAB2,GRIN2A,SPRED2,DUSP9,DOK4,FRS2,PSMA1,SPTB,PPP5C,UBB,VWF,CAMK2A,DUSP1,PSMB8,SPRED1,NRTN,CAMK2G,FGB,MAPK1,RASGRP3,FYN,PIK3R2,ERBB2,ERBB3,CALM1,TEK,PDGFA,RASAL1,KITLG,PSMB4,ARRB1,CAMK2D,NRG4,GRB2,KRAS,PPP2R5A,MAP2K1,PSMD3,PSMD7,JAK1,HBEGF,BTC,NEFL,PSME4,PRKACA,PDGFRA,PSMC4,FGFR2,ITGB3,PSMB9,PSMF1,RAP1GAP,FRS3,NF1,PSMA6,PPP2CA,PIK3R1,KSR1,PIK3CB,PDLIM7,IQGAP1,DOK6,FGF20,PSMC2,UBA52,KBTBD7,RASAL3,PTK2,BRAF,FGF2,NRG1,PTPRA,DUSP6,CSK,PSMA7,FGFR4,RASGRP4,GFRA3,PRKCA,SPTAN1,RASA2,GRB10,DUSP5,DUSP7,PTPN11,PSMA5,FGFR1,PSMD12,DUSP10,PIK3R3,IRS1,PDGFRB,KSR2,DAB2IP,GFRA4,DUSP16,KLB,PSMB3,PSMB1,RASGRF1,SEM1,JAK2,MIR5004,AKAP9,SRC,SOS1,FN1,FGG,YWHAB,PSMD1,GDNF,PSMA3,SHANK3,SHC1,FGF1,PSMB7,RASAL2,BRAP,SPTBN1,FGF3,PSMD14,IL3,PSMB10,NRAS R-HSA-166166 |MyD88-independent TLR3/TLR4 cascade |0.000158384320401569|-8.75048607084735|99 |62 |0.0136413641364136 |4545 |10287 |BIRC2,FOS,SARM1,PTPN11,DUSP7,MAPKAPK2,RPS6KA1,CASP8,NFKB2,MAP2K1,RIPK2,TAB3,MAPK14,UBE2D1,RPS6KA2,MEF2A,TAB1,CUL1,UBC,MIR718,NOD1,NFKBIA,UBE2D3,RIPK1,HMGB1,NFKB1,CD14,DUSP6,AGER,IKBKG,SKP1,RPS6KA3,PPP2R1B,BTRC,MAP2K7,BIRC3,MAP3K8,MAPK1,UBA52,ATF1,NFKBIB,IRAK1,TANK,UBE2N,MAP2K3,MAPKAPK3,MAP2K6,PPP2CA,DUSP3,CREB1,SAA1,TRAF3,IRAK2,UBE2V1,UBB,TAB2,NOD2,TBK1,FBXW11,LY96,JUN,APP R-HSA-937061 |TRIF-mediated TLR3/TLR4 signaling |0.000158384320401569|-8.75048607084735|99 |62 |0.0136413641364136 |4545 |10287 |PPP2CA,DUSP3,CREB1,SAA1,TRAF3,UBE2V1,IRAK2,UBB,NOD2,TAB2,TBK1,FBXW11,LY96,JUN,APP,RPS6KA3,PPP2R1B,BTRC,SKP1,BIRC3,MAP2K7,MAP3K8,MAPK1,UBA52,ATF1,NFKBIB,TANK,IRAK1,MAP2K3,UBE2N,MAPKAPK3,MAP2K6,UBE2D1,RPS6KA2,MEF2A,TAB1,CUL1,UBC,MIR718,NOD1,UBE2D3,NFKBIA,NFKB1,RIPK1,HMGB1,CD14,DUSP6,AGER,IKBKG,BIRC2,FOS,SARM1,PTPN11,MAPKAPK2,DUSP7,CASP8,RPS6KA1,NFKB2,MAP2K1,RIPK2,TAB3,MAPK14 R-HSA-168164 |Toll Like Receptor 3 (TLR3) Cascade |0.000158384320401569|-8.75048607084735|99 |62 |0.0136413641364136 |4545 |10287 |NFKBIB,TANK,IRAK1,MAP2K6,MAP2K3,UBE2N,MAPKAPK3,MAP2K7,BIRC3,MAP3K8,BTRC,SKP1,PPP2R1B,RPS6KA3,UBA52,ATF1,MAPK1,NOD2,UBB,TAB2,TBK1,FBXW11,UBE2V1,IRAK2,APP,JUN,LY96,PPP2CA,TRAF3,DUSP3,CREB1,SAA1,RIPK2,MAP2K1,MAPK14,TAB3,SARM1,PTPN11,BIRC2,FOS,NFKB2,DUSP7,MAPKAPK2,CASP8,RPS6KA1,RIPK1,HMGB1,NFKB1,NOD1,NFKBIA,UBE2D3,IKBKG,AGER,CD14,DUSP6,MEF2A,TAB1,UBE2D1,RPS6KA2,MIR718,CUL1,UBC R-HSA-1368108|BMAL1:CLOCK,NPAS2 activates circadian gene expression |0.000165984188705536|-8.70361802290601|48 |34 |0.00748074807480748 |4545 |10287 |NR3C1,ARNTL,F7,KLF15,NR1D1,CREM,CREB1,SMARCD3,CHD9,HIF1A,PER2,RXRA,HELZ2,RBM4,PPARGC1A,CREBBP,CRTC1,BHLHE40,SERPINE1,PPARA,PER1,NPAS2,MED1,NCOA1,NFIL3,CRY1,TBL1X,CARM1,NCOA2,EP300,RORA,MIR6883,DBP,NRIP1 R-HSA-352230 |Amino acid transport across the plasma membrane |0.000168943297258688|-8.68594741851971|31 |24 |0.00528052805280528 |4545 |10287 |SLC7A7,SLC43A1,SLC1A4,SLC38A3,SLC43A2,SLC7A1,SLC6A12,SLC7A9,SLC36A2,SLC1A5,SLC7A10,SLC38A5,SLC38A4,SLC38A1,SLC3A2,SLC6A6,SLC3A1,SLC7A2,SLC7A6,SLC7A8,SLC38A2,SLC6A14,SLC7A5,SLC7A11 R-HSA-168898 |Toll-Like Receptors Cascades |0.000172917911505775|-8.66269357604385|153 |90 |0.0198019801980198 |4545 |10287 |PIK3C3,PPP2R1B,EEA1,RPS6KA3,FGA,APOB,UBA52,LY86,TLR9,NFKBIB,PLCG2,TANK,IRAK1,MAP2K6,S100A9,PPP2CA,DUSP3,SAA1,CNPY3,TAB2,TLR5,FBXW11,TBK1,UBE2V1,SARM1,PTPN11,BIRC2,FOS,MAP3K1,DUSP7,MAPKAPK2,CASP8,MAPK14,UBE2D1,SOCS1,PTPN4,CD180,UBC,CD36,ECSIT,HMGB1,UBE2D3,AGER,IKBKG,CD14,DUSP6,BIRC3,MAP2K7,MAP3K8,CTSL,SKP1,BTRC,ATF1,FGB,MAPK1,DNM2,PELI1,UBE2N,MAP2K3,MAPKAPK3,TRAF3,CREB1,NOD2,UBB,IRAK2,JUN,APP,LY96,BPI,TLR6,NFKB2,ITGB2,RPS6KA1,RIPK2,MAP2K1,TAB3,TAB1,MEF2A,RPS6KA2,ITGAM,LGMN,MIR718,CUL1,NFKB1,RIPK1,LBP,NOD1,NFKBIA,CTSB,FGG R-HSA-418885 |DCC mediated attractive signaling |0.000200120503302677|-8.51659085634305|14 |13 |0.00286028602860286 |4545 |10287 |DCC,ABLIM1,ABLIM2,ABLIM3,CDC42,TRIO,WASL,FYN,PTK2,NTN1,DOCK1,NCK1,SRC R-HSA-450302 |activated TAK1 mediates p38 MAPK activation |0.000208526466788731|-8.47544458574681|20 |17 |0.00374037403740374 |4545 |10287 |MAPK14,MAP2K6,MAPKAPK3,MAP2K3,UBE2N,TAB3,RIPK2,IRAK1,MAPKAPK2,IKBKG,TAB2,NOD2,IRAK2,UBE2V1,NOD1,MIR718,TAB1 R-HSA-3299685|Detoxification of Reactive Oxygen Species |0.00021387892561461 |-8.45010047120565|38 |28 |0.00616061606160616 |4545 |10287 |CYBA,GPX1,GPX8,PRDX2,TXNRD2,SOD2,TXN2,CYCS,NCF2,NOX5,PRDX5,P4HB,GPX7,SOD1,TXNRD1,GPX6,GSR,TXN,GPX5,CAT,NUDT2,PRDX1,GSTP1,PRDX3,PRDX6,GPX3,AQP8,GPX2 R-HSA-174800 |Chylomicron-mediated lipid transport |0.000218608393988237|-8.42822858411076|28 |22 |0.00484048404840484 |4545 |10287 |APOA2,LIPC,MBTPS2,APOC3,APOA1,CIDEC,LDLR,PCSK6,APOB,CREB3L3,FGF21,ANGPTL8,P4HB,APOA4,LDLRAP1,APOC2,MIR6886,FURIN,ANGPTL3,APOA5,SAR1B,MBTPS1 R-HSA-451927 |Interleukin-2 signaling |0.00024868493717063 |-8.29932377525117|262 |144 |0.0316831683168317 |4545 |10287 |UBA52,KBTBD7,PTK2,BRAF,RASAL3,FGF2,KSR1,PIK3R1,IQGAP1,PIK3CB,LGALS9,FGF20,PSMC2,PSMB9,PSMF1,NF1,FRS3,PPP2CA,PSMA6,PSMC4,ITGB3,FGFR2,DUSP7,PSMA5,SPTAN1,RASA2,DUSP5,RASGRP4,GFRA3,FGFR4,PTPRA,NRG1,PSMA7,DUSP6,CSK,SRC,AKAP9,SOS1,FN1,KSR2,DAB2IP,KLB,PSMB3,DUSP16,GFRA4,PSMB1,RASGRF1,MIR5004,JAK2,SEM1,PIK3R3,IRS1,PDGFRB,FGFR1,DUSP10,PSMD12,PSMB10,IL3,NRAS,FGF3,PSMD14,FGF1,SHC1,RASAL2,BRAP,PSMB7,SPTBN1,FGG,GDNF,PSMD1,YWHAB,INPP5D,PSMA3,KIT,PEBP1,PPP2R1B,FGA,FGFR3,FGF9,FGF19,SYNGAP1,CAMK2B,RAF1,RAPGEF2,STAT5A,RASA3,FGF10,PSMB5,DUSP9,FRS2,EGF,CALM2,GAB2,GRIN2A,SPRED2,RASGRF2,MARK3,UBC,VCL,KL,RANBP9,SHC3,PSMB11,MAPK1,FGB,FYN,RASGRP3,PTK2B,PIK3R2,ERBB2,PSMB8,SPRED1,NRTN,CAMK2G,STAT5B,CAMK2A,VWF,DUSP1,PSMA1,SPTB,PPP5C,UBB,PSMD7,JAK1,PSMD3,NEFL,BTC,HBEGF,PSME4,PDGFRA,NRG4,CAMK2D,GRB2,KRAS,MAP2K1,PPP2R5A,RASAL1,PSMB4,KITLG,ARRB1,CALM1,ERBB3,PDGFA,TEK R-HSA-167044 |Signalling to RAS |0.000253203144245086|-8.28131844974179|256 |141 |0.031023102310231 |4545 |10287 |ITGB3,FGFR2,PSMC4,PPP2CA,PSMA6,PSMB9,PSMF1,NF1,FRS3,FGF20,PSMC2,KSR1,IQGAP1,RALA,BRAF,PTK2,RASAL3,FGF2,UBA52,KBTBD7,PTPRA,NRG1,PSMA7,DUSP6,CSK,GFRA3,RASGRP4,FGFR4,DUSP5,SPTAN1,RASA2,PSMA5,DUSP7,FGFR1,DUSP10,PSMD12,PDGFRB,IRS1,RASGRF1,PSMB1,MIR5004,JAK2,SEM1,KSR2,DAB2IP,MAPKAPK3,KLB,PSMB3,GFRA4,DUSP16,MAPK13,FN1,SRC,AKAP9,SOS1,PSMA3,FGG,PSMD1,GDNF,YWHAB,BRAP,RASAL2,PSMB7,SPTBN1,FGF1,SHC1,FGF3,PSMD14,NRAS,PSMB10,IL3,PSMB5,RASA3,FGF10,RAPGEF2,RAF1,FGF19,SYNGAP1,CAMK2B,FGA,FGFR3,PPP2R1B,FGF9,KIT,PEBP1,PSMB11,KL,SHC3,RANBP9,RASGRF2,MARK3,VCL,UBC,GRIN2A,SPRED2,EGF,MAPK14,CALM2,RALB,FRS2,DUSP9,MAPKAPK2,UBB,SPTB,PSMA1,PPP5C,CAMK2A,VWF,DUSP1,NRTN,CAMK2G,SPRED1,PSMB8,FYN,RASGRP3,ERBB2,MAPK1,FGB,PDGFA,TEK,CALM1,ERBB3,ARRB1,RASAL1,PSMB4,KITLG,RALGDS,KRAS,MAP2K1,PPP2R5A,NRG4,CAMK2D,GRB2,PSME4,PDGFRA,JAK1,PSMD7,PSMD3,NEFL,BTC,HBEGF R-HSA-194840 |Rho GTPase cycle |0.000299227238838177|-8.11430727711009|143 |84 |0.0184818481848185 |4545 |10287 |ARHGAP17,ARHGAP12,PIK3R2,ARHGDIA,ARHGEF4,BCR,SOS1,ARHGEF10L,RHOG,MYO9B,LOC101928168,CHN1,ARHGAP45,ARHGAP32,FGD4,VAV3,MIR7706,FAM13A,ARHGAP15,AKAP13,ARHGAP27,ABR,ARAP3,KALRN,SRGAP1,RHOU,RHOB,PLEKHG2,ARAP2,ARHGAP26,ARHGAP21,ARHGEF10,RACGAP1,ARHGEF6,OCRL,ARHGEF12,ARHGEF16,NGEF,RHOBTB1,CDC42,STARD8,ARHGAP29,ARHGEF3,INPP5B,ARAP1,ARHGAP35,RALBP1,ARHGEF26,FGD2,CHN2,VAV2,ARHGEF2,ARHGEF1,ITSN1,DLC1,TRIP10,DEPDC1B,ARHGAP22,A2M,RHOD,RHOBTB2,RHOF,ARHGAP24,RHOQ,RHOH,MCF2L,PREX1,RHOT2,SYDE1,RHOV,ARHGEF19,RASGRF2,ARHGAP40,NET1,OBSCN,ARHGAP1,ARHGAP23,RHOA,ARHGEF7,TIAM2,ARHGAP19,TRIO,STARD13,ARHGAP18 R-HSA-912526 |Interleukin receptor SHC signaling |0.000321170128734733|-8.04353957917421|255 |140 |0.0308030803080308 |4545 |10287 |PSMD12,DUSP10,FGFR1,IRS1,PIK3R3,PDGFRB,DUSP16,GFRA4,PSMB3,KLB,DAB2IP,KSR2,JAK2,SEM1,MIR5004,RASGRF1,PSMB1,SOS1,AKAP9,SRC,FN1,YWHAB,PSMD1,GDNF,FGG,PSMA3,INPP5D,SHC1,FGF1,SPTBN1,PSMB7,BRAP,RASAL2,PSMD14,FGF3,PSMB10,IL3,NRAS,PSMC4,FGFR2,ITGB3,FRS3,NF1,PSMF1,PSMB9,PSMA6,PPP2CA,PIK3CB,IQGAP1,PIK3R1,KSR1,FGF20,PSMC2,KBTBD7,UBA52,FGF2,RASAL3,BRAF,PTK2,CSK,DUSP6,PSMA7,NRG1,PTPRA,FGFR4,RASGRP4,GFRA3,RASA2,SPTAN1,DUSP5,DUSP7,PSMA5,PPP5C,PSMA1,SPTB,UBB,DUSP1,VWF,CAMK2A,PSMB8,SPRED1,CAMK2G,NRTN,FGB,MAPK1,PIK3R2,ERBB2,RASGRP3,FYN,ERBB3,CALM1,TEK,PDGFA,KITLG,PSMB4,RASAL1,ARRB1,GRB2,CAMK2D,NRG4,PPP2R5A,MAP2K1,KRAS,BTC,HBEGF,NEFL,PSMD3,JAK1,PSMD7,PDGFRA,PSME4,FGF10,RASA3,PSMB5,RAF1,RAPGEF2,CAMK2B,SYNGAP1,FGF19,PEBP1,KIT,FGF9,FGA,FGFR3,PPP2R1B,PSMB11,UBC,VCL,MARK3,RASGRF2,SHC3,RANBP9,KL,CALM2,EGF,GRIN2A,SPRED2,GAB2,DUSP9,FRS2 R-HSA-5684996|MAPK1/MAPK3 signaling |0.000325253257332712|-8.03090642576335|251 |138 |0.0303630363036304 |4545 |10287 |UBB,PPP5C,SPTB,PSMA1,DUSP1,CAMK2A,VWF,CAMK2G,NRTN,SPRED1,PSMB8,ERBB2,FYN,RASGRP3,MAPK1,FGB,PDGFA,TEK,CALM1,ERBB3,ARRB1,PSMB4,KITLG,RASAL1,MAP2K1,PPP2R5A,TYK2,KRAS,GRB2,NRG4,CAMK2D,PDGFRA,PSME4,NEFL,BTC,HBEGF,PSMD7,JAK1,PSMD3,PSMB5,FGF10,RASA3,RAPGEF2,IL6R,RAF1,SYNGAP1,CAMK2B,FGF19,FGA,FGFR3,PPP2R1B,FGF9,PEBP1,KIT,PSMB11,KL,SHC3,RANBP9,UBC,VCL,MARK3,RASGRF2,GRIN2A,SPRED2,CALM2,EGF,FRS2,DUSP9,DUSP10,PSMD12,FGFR1,PDGFRB,IRS1,MIR5004,JAK2,SEM1,RASGRF1,PSMB1,PSMB3,KLB,GFRA4,DUSP16,KSR2,DAB2IP,FN1,SOS1,SRC,AKAP9,PSMA3,PSMD1,GDNF,YWHAB,FGG,SPTBN1,RASAL2,BRAP,PSMB7,FGF1,SHC1,PSMD14,FGF3,NRAS,IL6ST,IL3,PSMB10,ITGB3,FGFR2,PSMC4,PPP2CA,PSMA6,NF1,FRS3,PSMB9,PSMF1,PSMC2,FGF20,IQGAP1,KSR1,FGF2,PTK2,BRAF,RASAL3,KBTBD7,UBA52,PSMA7,DUSP6,CSK,NRG1,PTPRA,RASGRP4,GFRA3,FGFR4,DUSP5,RASA2,SPTAN1,PSMA5,PTPN11,DUSP7 R-HSA-5607764|CLEC7A (Dectin-1) signaling |0.000353408012963211|-7.94788732441606|101 |62 |0.0136413641364136 |4545 |10287 |SKP1,BTRC,SRC,UBA52,SEM1,PSMC2,ITPR2,PPP3CA,PLCG2,PSMB1,PSMB3,UBE2N,PSMB8,CARD11,PSMA6,MALT1,PSMB9,NFATC2,PSMF1,ITPR3,NFATC3,UBE2V1,PSMB5,FBXW11,TAB2,UBB,PSMC4,PSMD12,PSMA1,PSMA5,PSME4,CASP8,IL1B,PSMD7,AHCYL1,PSMD3,NFKB2,PSMB10,CARD9,ITPR1,TAB3,CALM2,PSMD14,PDPK1,UBE2D1,TAB1,PSMB7,UBC,BCL10,PSMB4,CUL1,MAP3K14,NFKBIA,PSMB11,PRKCD,PSMA3,NFKB1,CDC34,PSMD1,PSMA7,CALM1,IKBKG R-HSA-168142 |Toll Like Receptor 10 (TLR10) Cascade |0.000355468087485154|-7.94207508072462|84 |53 |0.0116611661166117 |4545 |10287 |TLR5,FBXW11,UBB,NOD2,TAB2,UBE2V1,IRAK2,APP,JUN,PPP2CA,SAA1,CREB1,DUSP3,IRAK1,NFKBIB,PELI1,MAP2K6,MAPKAPK3,UBE2N,MAP2K3,MAP3K8,MAP2K7,BTRC,PPP2R1B,SKP1,RPS6KA3,ATF1,UBA52,MAPK1,HMGB1,NFKB1,ECSIT,NFKBIA,NOD1,IKBKG,AGER,DUSP6,MEF2A,TAB1,RPS6KA2,MIR718,UBC,CUL1,RIPK2,MAP2K1,MAPK14,TAB3,FOS,NFKB2,MAP3K1,RPS6KA1,DUSP7,MAPKAPK2 R-HSA-975871 |MyD88 cascade initiated on plasma membrane |0.000355468087485154|-7.94207508072462|84 |53 |0.0116611661166117 |4545 |10287 |ATF1,UBA52,MAPK1,MAP3K8,MAP2K7,RPS6KA3,BTRC,PPP2R1B,SKP1,PELI1,MAP2K6,MAPKAPK3,UBE2N,MAP2K3,IRAK1,NFKBIB,SAA1,CREB1,DUSP3,PPP2CA,APP,JUN,FBXW11,TLR5,NOD2,UBB,TAB2,IRAK2,UBE2V1,MAP3K1,NFKB2,RPS6KA1,MAPKAPK2,DUSP7,FOS,MAPK14,TAB3,RIPK2,MAP2K1,MIR718,UBC,CUL1,MEF2A,TAB1,RPS6KA2,IKBKG,AGER,DUSP6,HMGB1,NFKB1,ECSIT,NFKBIA,NOD1 R-HSA-168176 |Toll Like Receptor 5 (TLR5) Cascade |0.000355468087485154|-7.94207508072462|84 |53 |0.0116611661166117 |4545 |10287 |MAP2K1,RIPK2,TAB3,MAPK14,FOS,RPS6KA1,MAPKAPK2,DUSP7,NFKB2,MAP3K1,NFKBIA,NOD1,NFKB1,HMGB1,ECSIT,DUSP6,IKBKG,AGER,RPS6KA2,TAB1,MEF2A,UBC,CUL1,MIR718,IRAK1,NFKBIB,MAPKAPK3,UBE2N,MAP2K3,PELI1,MAP2K6,BTRC,SKP1,PPP2R1B,RPS6KA3,MAP3K8,MAP2K7,MAPK1,ATF1,UBA52,UBE2V1,IRAK2,FBXW11,TLR5,UBB,TAB2,NOD2,APP,JUN,PPP2CA,SAA1,CREB1,DUSP3 R-HSA-2029480|Fcgamma receptor (FCGR) dependent phagocytosis |0.000374518615084936|-7.8898690497405 |86 |54 |0.0118811881188119 |4545 |10287 |FGR,VAV3,VAV2,ITPR3,PRKCE,MYH9,ACTG1,CYFIP2,LYN,PLD1,ABL1,ELMO1,PIK3R2,WASL,PTK2,FYN,MAPK1,FCGR3A,SRC,YES1,HSP90AA1,ACTR3,CRK,ARPC1B,PLCG2,ITPR2,MYO9B,PLA2G6,PAK1,ACTR2,PIK3CB,PIK3R1,WASF1,ARPC1A,DOCK1,FCGR2A,NCKAP1,ABI2,PRKCD,ACTB,HSP90AB1,CDC42,MYO1C,PLPP5,CD247,ABI1,NCK1,ARPC5,ARPC2,AHCYL1,CYFIP1,ITPR1,WASF2,GRB2 R-HSA-1643685|Disease |0.000386459518147517|-7.85848343501483|859 |427 |0.0939493949394939 |4545 |10287 |RPS6KB2,CANX,RPL10A,RPS11,ELOA,RPL31,AP2M1,HSPG2,FGFR4,NELFCD,MUC2,SDC1,NOTCH3,HSPA1A,THBS1,RPS21,RPL21,GPC3,GCK,FMOD,PTPN11,RNF185,RPL5,PSMA5,TRAK1,ADAMTS13,LRP5,MC2R,TAF4,XRCC6,RLBP1,EEF2,ITGB3,GSK3A,RPS15,AP1S2,ERLIN2,HDAC2,HDAC11,NELFA,CDKN1A,RPLP1,PIK3R1,IQGAP1,TGFBR2,LMNB1,PSMC2,FGF20,ADAMTS17,QKI,SOD2,BRAF,NCOR2,RASAL3,SYVN1,HSP90AB1,YWHAB,EPS15,TRIM24,KPNB1,FGF1,RPL19,SHC1,BRAP,ATG7,PSMB7,TCF7L2,MDM2,IDH1,TBP,TAF11,AKT3,ANTXR1,IPO5,DERL1,PSMB10,NEURL1B,STRA6,TLR6,NRAS,PDCD6IP,MYO18A,CNTRL,NUP85,PSMD12,GYG1,XPO1,CCDC59,TRAF3,GCKR,ADAMTS6,KAT2B,KSR2,ELOC,PSMB3,KLB,AP2B1,PAPSS1,FZD4,CREBBP,MIB1,JAK2,KPNA3,FN1,SKP1,SDC2,IKBKG,GSK3B,CD14,BCL2L11,RPL15,PSMB11,RBP4,DNAJC3,ZC3HAV1,VCL,NR4A1,KL,ADAMTS10,EGF,GTF2F2,RPL36,RPL13,NUP35,ABCC8,TBL1X,CALM2,GAB2,RBPJ,AP1S3,NMT1,GPC5,RASA3,MIR6805,NOTCH1,PSMB5,RPL18A,TNKS,CDC25B,CAPN2,SEMA5B,STAT1,STAT5A,LRRFIP1,OPN1SW,LMNA,GTF2F1,AP2A2,RAE1,ACACA,FGF19,CHMP2A,MUC13,NFKBIB,CDK5R1,ANTXR2,PEBP1,PPP2R1B,FGA,PPIA,AP1M1,FGF9,GTF2B,CALM1,ERBB3,CXCR4,CHMP4B,PDGFA,RPL24,RASAL1,SMAD3,JAG1,PSMB4,ARRB1,GPC4,SEH1L,TNKS2,NCSTN,NRG4,STAT3,GRB2,RPS15A,ERLIN1,KRAS,MACF1,MAP2K1,SH3GL1,PSMD7,AGGF1,PSMD3,MMADHC,HBEGF,RPL34,SDC4,MPRIP,TENT4A,STAT5B,CREB1,MTOR,TAF3,RPS4Y2,MUC3A,RPL13A,RPL38,FDXR,RANBP2,RANGAP1,MAPK1,BCR,FGB,BTRC,NUP210,PIK3R2,RPS19,NUP188,ERBB2,HDAC4,NRG1,MAML1,HES1,PSMA7,CSK,RPS27,OPN1LW,AP2A1,CDH1,CHMP3,RPL23A,SEL1L,PAK2,PRDX2,CHMP4A,RPL12,RASA2,FOXO3,VAMP1,CD80,RPL22L1,STX1A,AGTRAP,MMACHC,PSMC4,PRR5,FGFR2,NELFE,PSMF1,PSMB9,NF1,RPLP2,PPP2CA,PSMA6,KSR1,MAP2K6,MTRR,PIK3CB,ADAMTSL4,UBA52,GTF2A1,THSD4,CAPN1,FGF2,CPSF4,FGG,PSMD1,PSMA3,NFKBIA,RPS5,KPNA2,CD28,NUP43,ELL,CHMP4C,RASAL2,AXIN1,HEYL,CTNNB1,ISG15,TAF1,HDAC5,RNF43,FGF3,PSMD14,CHMP2B,ADAMTS2,NFKB2,MAPKAP1,SFTPA1,RAN,FZD5,HDAC8,MIR1257,FGFR1,CCNH,NEDD4L,APP,RPL32,DAG1,LY96,EPM2A,CCNT2,VAMP2,PIK3R3,IRS1,BAG4,RPL23,ERLEC1,PDGFRB,CAST,DAB2IP,RICTOR,MAP2K3,PSMB1,MIR6869,CHMP6,MIR5004,VCAN,SEM1,SRC,SMAD4,AKAP9,KPNA7,SOS1,PABPN1,GYS2,VPS37B,KPNA1,CD36,NUP58,TXNRD1,MARK3,VPS4B,CUX1,POMC,POLR2E,UBC,LIG4,OS9,FURIN,TSC2,NUP214,NUP42,RPS24,MTR,EP300,PCCB,FRS2,FGF10,TLR5,NUP205,GYS1,GPC6,ARF1,ADAMTSL1,RAF1,CASP9,AP2S1,PACS1,VPS4A,ADAM17,AKT1S1,AVPR1A,KREMEN1,AMN,SYNGAP1,DKK4,HSP90AA1,RPL26,SLC25A4,KIT,FDX1,FGFR3,TAF6,NUP93,MUC5B,SDC3,NFKB1,CD9,SUPT4H1,CUL1,KITLG,PRDX1,XRCC5,PDPK1,SH3KBP1,SHH,RPS3A,FASLG,RPS13,MMAA,PPP2R5A,GPC1,BTC,CD247,IHH,TAF12,PSME4,THBS2,KIAA0754,PDGFRA,POLR2A,PSMA1,JUN,CAPNS1,RPS16,UBB,CDK8,ALB,POLR2D,STX1B,STAM,SPON2,ZMYM2,RNMT,CPSF6,PIK3AP1,DKK1,VWF,PSMB8,PPP1R3C,RPS9,SPON1,GUCY2C,RPL9,FYN,MAP2K7,ELMO1,RPS20 R-HSA-169893 |Prolonged ERK activation events |0.000409028186160328|-7.80172648947856|252 |138 |0.0303630363036304 |4545 |10287 |RAPGEF2,RAF1,PSMB5,FGF10,RASA3,FGA,PPP2R1B,FGFR3,FGF9,PEBP1,KIT,SYNGAP1,CAMK2B,FGF19,KL,RANBP9,SHC3,VCL,UBC,MARK3,RASGRF2,PSMB11,FRS2,DUSP9,SPRED2,GRIN2A,CALM2,EGF,DUSP1,CAMK2A,VWF,UBB,PPP5C,SPTB,PSMA1,ERBB2,FYN,RASGRP3,MAPK1,FGB,CAMK2G,NRTN,SPRED1,PSMB8,ARRB1,PSMB4,KITLG,RASAL1,PDGFA,TEK,CALM1,ERBB3,PDGFRA,PSME4,NEFL,BTC,HBEGF,PSMD7,JAK1,PSMD3,MAP2K1,PPP2R5A,KRAS,GRB2,NRG4,CAMK2D,PPP2CA,PSMA6,NF1,FRS3,PSMB9,PSMF1,ITGB3,FGFR2,PSMC4,FGF2,PTK2,BRAF,RASAL3,KBTBD7,UBA52,FGF20,PSMC2,IQGAP1,KSR1,RAPGEF1,RASGRP4,GFRA3,FGFR4,PSMA7,CSK,DUSP6,NRG1,PTPRA,PSMA5,DUSP7,DUSP5,RASA2,SPTAN1,PDGFRB,IRS1,CRKL,DUSP10,PSMD12,FGFR1,FN1,SOS1,SRC,CRK,AKAP9,MIR5004,JAK2,SEM1,PSMB1,RASGRF1,PSMB3,KLB,DUSP16,GFRA4,DAB2IP,KSR2,SPTBN1,RASAL2,BRAP,PSMB7,FGF1,SHC1,PSMA3,PSMD1,GDNF,YWHAB,FGG,NRAS,PSMB10,IL3,KIDINS220,PSMD14,FGF3 R-HSA-6802957|Oncogenic MAPK signaling |0.00041270267411002 |-7.79278314167737|75 |48 |0.0105610561056106 |4545 |10287 |KSR1,LMNA,KSR2,DAB2IP,IQGAP1,QKI,JAK2,PAPSS1,SYNGAP1,MIR5004,AKAP9,SRC,PEBP1,FGB,MAPK1,RASAL3,BRAF,FN1,FGA,RASA3,MPRIP,ITGB3,TENT4A,RAF1,NF1,VWF,RASA2,KRAS,MAP2K1,MACF1,AGGF1,KIAA0754,NRAS,AGTRAP,TRAK1,FGG,CSK,BCL2L11,YWHAB,RASAL1,MARK3,TRIM24,VCL,ZC3HAV1,ARRB1,RASAL2,BRAP,ATG7 R-HSA-450294 |MAP kinase activation in TLR cascade |0.000428584413584118|-7.75502284146539|64 |42 |0.00924092409240924 |4545 |10287 |NFKB1,NOD1,IKBKG,DUSP6,TAB1,MEF2A,RPS6KA2,MIR718,UBC,CUL1,RIPK2,MAP2K1,MAPK14,TAB3,FOS,RPS6KA1,MAPKAPK2,DUSP7,FBXW11,TAB2,UBB,NOD2,IRAK2,UBE2V1,JUN,PPP2CA,DUSP3,CREB1,IRAK1,MAP2K6,MAPKAPK3,UBE2N,MAP2K3,MAP3K8,MAP2K7,BTRC,SKP1,PPP2R1B,RPS6KA3,ATF1,UBA52,MAPK1 R-HSA-2871796|FCERI mediated MAPK activation |0.000487258641857813|-7.62671548375069|265 |144 |0.0316831683168317 |4545 |10287 |PSMA3,FGG,YWHAB,GDNF,PSMD1,PSMB7,BRAP,RASAL2,SPTBN1,SHC1,FGF1,FGF3,PSMD14,NRAS,PSMB10,IL3,FGFR1,PSMD12,DUSP10,PDGFRB,IRS1,PSMB1,RASGRF1,JAK2,SEM1,MIR5004,KSR2,DAB2IP,DUSP16,GFRA4,KLB,PSMB3,FN1,AKAP9,SRC,SOS1,NRG1,PTPRA,CSK,DUSP6,PSMA7,FGFR4,RASGRP4,GFRA3,DUSP5,SPTAN1,PAK2,RASA2,PSMA5,DUSP7,FGFR2,ITGB3,PSMC4,PSMA6,PPP2CA,PSMF1,PSMB9,FRS3,NF1,PAK1,FGF20,PSMC2,KSR1,IQGAP1,RASAL3,PTK2,BRAF,FGF2,UBA52,KBTBD7,TEK,PDGFA,CALM1,ERBB3,ARRB1,RASAL1,PSMB4,KITLG,KRAS,PPP2R5A,MAP2K1,CAMK2D,NRG4,GRB2,PSME4,PDGFRA,PSMD3,JAK1,PSMD7,BTC,HBEGF,NEFL,UBB,JUN,PSMA1,SPTB,PPP5C,VWF,VAV3,CAMK2A,DUSP1,NRTN,CAMK2G,PSMB8,SPRED1,RASGRP3,MAP2K7,FYN,ERBB2,FGB,MAPK1,PSMB11,RANBP9,SHC3,KL,RASGRF2,MARK3,UBC,VCL,SPRED2,GRIN2A,EGF,CALM2,FRS2,FOS,DUSP9,MAP3K1,LYN,PSMB5,RASA3,FGF10,VAV2,RAPGEF2,RAF1,FGF19,PLCG2,CAMK2B,SYNGAP1,FGF9,FGFR3,FGA,PPP2R1B,KIT,PEBP1 R-HSA-6798695|Neutrophil degranulation |0.000497022127899428|-7.60687600992229|487 |251 |0.0552255225522552 |4545 |10287 |PSMD1,HSP90AB1,CYSTM1,STK10,EPX,QPCT,CTSB,ACTR1B,HP,ITGAM,KPNB1,SLCO4C1,CTSD,ATG7,CCT2,PSMB7,PNP,IDH1,PSMD14,DSC1,LAMP1,VAMP8,LGALS3,TOLLIP,ELANE,S100P,MMP9,ITGB2,RAB3D,TOM1,NRAS,KCMF1,CXCR1,PSMD12,GOLGA7,GLB1,GYG1,HGSNAT,PGM1,OSTF1,PYGB,ADA2,ANXA2,TYROBP,ITGAL,BRI3,ACTR2,VAPA,PRDX4,BST2,STOM,PSMB1,CSNK2B,PFKL,RAB7A,AHSG,RHOG,LAMP2,ALAD,ATP11B,CRISPLD2,GPI,KCNAB2,RAB5B,ANO6,RHOA,CD68,SURF4,PLEKHO2,IGF2R,AGPAT2,CTSC,CST3,FTH1,RNASE2,HSPA1A,DGAT1,SPTAN1,CYBA,CYFIP1,RHOF,IQGAP2,RAP2B,PLAC8,SLC2A5,SERPINB1,HSPA8,CAMP,CHIT1,PRCP,ORM2,HEBP2,PSMA5,XRCC6,SLC27A2,COMMD9,EEF2,ACAA1,FTL,GSN,SERPINB6,SLPI,RAB14,TMEM63A,DSN1,NFAM1,DNAJC5,JUP,SVIP,IQGAP1,UNC13D,LCN2,PSMC2,TRPM2,CREG1,GGH,PSEN1,CAPN1,SERPINA1,TXNDC5,CTSH,EEF1A1,CEACAM8,ARG1,DSG1,RAB27A,CMTM6,HSPA1B,RAB37,PKM,TSPAN14,NFKB1,MVP,LPCAT1,IMPDH2,ARL8A,NCSTN,CKAP4,GSTP1,SCAMP1,XRCC5,APRT,ARPC5,PSMD7,CAND1,PSMD3,CALML5,SNAP29,TUBB,DYNC1H1,PLD1,BPI,SLC11A1,FAF2,IMPDH1,YPEL5,MGST1,HVCN1,DEGS1,GM2A,HSPA6,S100A11,OLFM4,TMEM173,CTSZ,SYNGR1,PECAM1,STBD1,ARSB,GSDMD,NFASC,ARHGAP45,MAPK1,CSTB,ATP6V0C,DDX3X,CD14,CD53,SIRPA,LTA4H,C5AR1,NEU1,LRG1,PRKCD,HMGB1,RAB6A,VAT1,CD36,ALDOA,FCGR2A,VCL,RAB5C,RAB31,MIR6848,DNAJC3,PRDX6,PGRMC1,SERPINA3,MANBA,PGM2,TMC6,QSOX1,ILF2,MAPK14,C3,CFD,CDK13,ITGAX,ADGRE3,COTL1,NIT2,DYNC1LI1,HEXB,TMBIM1,ACLY,ATP11A,CAB39,PDXK,ATAD3B,ARSA,ANPEP,CD55,ORM1,GPR84,ROCK1,MIF,ADAM8,GUSB,RAB10,DSP,METTL7A,PRSS3,FGR,CPNE1,CAT,DIAPH1,S100A9,PYGL,AP2A2,ALDH3B1,ATP6AP2,APEH,ATP6V1D,IST1,PTPRJ,HSP90AA1,ADGRG3,AP1M1,PSAP,ATP6V0A1,PPIA R-HSA-416572 |Sema4D induced cell migration and growth-cone collapse |0.000508726364663114|-7.5836002799513 |24 |19 |0.00418041804180418 |4545 |10287 |RHOB,CDC42,RHOA,RND1,MYL12B,MYH11,ROCK1,MYH9,MYL6,MYH14,ARHGEF12,LIMK2,PLXNB1,ROCK2,SEMA4D,MYL9,RHOG,MYH10,ERBB2 R-HSA-170984 |ARMS-mediated activation |0.000519953319508839|-7.56177152059369|249 |136 |0.0299229922992299 |4545 |10287 |RASGRF2,MARK3,VCL,UBC,SHC3,RANBP9,KL,PSMB11,DUSP9,FRS2,EGF,CALM2,SPRED2,GRIN2A,RAF1,RAPGEF2,RASA3,FGF10,PSMB5,KIT,PEBP1,FGF9,PPP2R1B,FGFR3,FGA,FGF19,CAMK2B,SYNGAP1,RASAL1,PSMB4,KITLG,ARRB1,CALM1,ERBB3,TEK,PDGFA,PSMD3,JAK1,PSMD7,HBEGF,BTC,NEFL,PSME4,PDGFRA,CAMK2D,NRG4,GRB2,KRAS,PPP2R5A,MAP2K1,VWF,CAMK2A,DUSP1,SPTB,PSMA1,PPP5C,UBB,FGB,MAPK1,RASGRP3,FYN,ERBB2,PSMB8,SPRED1,NRTN,CAMK2G,FGFR4,RASGRP4,GFRA3,NRG1,PTPRA,CSK,DUSP6,PSMA7,DUSP7,PSMA5,SPTAN1,RASA2,DUSP5,PSMF1,PSMB9,FRS3,NF1,PSMA6,PPP2CA,PSMC4,FGFR2,ITGB3,UBA52,KBTBD7,RASAL3,BRAF,PTK2,FGF2,KSR1,IQGAP1,PSMC2,FGF20,SHC1,FGF1,PSMB7,RASAL2,BRAP,SPTBN1,FGG,YWHAB,GDNF,PSMD1,PSMA3,IL3,PSMB10,NRAS,FGF3,PSMD14,KIDINS220,IRS1,PDGFRB,FGFR1,PSMD12,DUSP10,CRK,AKAP9,SRC,SOS1,FN1,KSR2,DAB2IP,GFRA4,DUSP16,PSMB3,KLB,PSMB1,RASGRF1,SEM1,JAK2,MIR5004 R-HSA-390918 |Peroxisomal lipid metabolism |0.000527382000221613|-7.54758541390014|29 |22 |0.00484048404840484 |4545 |10287 |ACOX2,ACAA1,MLYCD,SLC27A2,AGPS,ACOX1,ACBD4,SLC25A17,ECI2,CRAT,ABCD1,ACOX3,ALDH3A2,HSD17B4,GNPAT,IDH1,NUDT19,AMACR,NUDT7,PHYH,SCP2,PECR R-HSA-2032785|YAP1- and WWTR1 (TAZ)-stimulated gene expression |0.000527382000221613|-7.54758541390014|29 |22 |0.00484048404840484 |4545 |10287 |CREBBP,CCN2,CARM1,TEAD4,NCOA2,HELZ2,TBL1X,RUNX2,PPARA,NKX2-5,HIPK2,HIPK1,WWTR1,GATA4,MED1,YAP1,TEAD1,CHD9,RXRA,NCOA1,KAT2B,SMARCD3 R-HSA-5673001|RAF/MAP kinase cascade |0.000527745412319241|-7.5468965641789 |245 |134 |0.0294829482948295 |4545 |10287 |GFRA3,RASGRP4,FGFR4,PSMA7,CSK,DUSP6,PTPRA,NRG1,DUSP7,PSMA5,RASA2,SPTAN1,DUSP5,NF1,FRS3,PSMF1,PSMB9,PPP2CA,PSMA6,PSMC4,ITGB3,FGFR2,KBTBD7,UBA52,FGF2,PTK2,BRAF,RASAL3,IQGAP1,KSR1,PSMC2,FGF20,FGF1,SHC1,SPTBN1,RASAL2,BRAP,PSMB7,PSMD1,GDNF,YWHAB,FGG,PSMA3,IL3,PSMB10,NRAS,PSMD14,FGF3,IRS1,PDGFRB,DUSP10,PSMD12,FGFR1,SOS1,SRC,AKAP9,FN1,PSMB3,KLB,DUSP16,GFRA4,KSR2,DAB2IP,MIR5004,SEM1,JAK2,RASGRF1,PSMB1,VCL,UBC,MARK3,RASGRF2,KL,SHC3,RANBP9,PSMB11,DUSP9,FRS2,CALM2,EGF,GRIN2A,SPRED2,RAF1,RAPGEF2,FGF10,RASA3,PSMB5,PEBP1,KIT,FGA,FGFR3,PPP2R1B,FGF9,SYNGAP1,CAMK2B,FGF19,PSMB4,KITLG,RASAL1,ARRB1,ERBB3,CALM1,PDGFA,TEK,NEFL,BTC,HBEGF,JAK1,PSMD7,PSMD3,PDGFRA,PSME4,GRB2,NRG4,CAMK2D,MAP2K1,PPP2R5A,KRAS,DUSP1,CAMK2A,VWF,PPP5C,PSMA1,SPTB,UBB,MAPK1,FGB,ERBB2,FYN,RASGRP3,PSMB8,SPRED1,CAMK2G,NRTN R-HSA-112412 |SOS-mediated signalling |0.000527745412319241|-7.5468965641789 |245 |134 |0.0294829482948295 |4545 |10287 |PDGFA,TEK,ERBB3,CALM1,ARRB1,PSMB4,KITLG,RASAL1,MAP2K1,PPP2R5A,KRAS,GRB2,NRG4,CAMK2D,PDGFRA,PSME4,NEFL,BTC,HBEGF,PSMD7,JAK1,PSMD3,UBB,PPP5C,SPTB,PSMA1,DUSP1,CAMK2A,VWF,CAMK2G,NRTN,SPRED1,PSMB8,ERBB2,FYN,RASGRP3,MAPK1,FGB,PSMB11,KL,RANBP9,SHC3,UBC,VCL,MARK3,RASGRF2,SPRED2,GRIN2A,CALM2,EGF,FRS2,DUSP9,PSMB5,FGF10,RASA3,RAPGEF2,RAF1,SYNGAP1,CAMK2B,FGF19,FGFR3,FGA,PPP2R1B,FGF9,PEBP1,KIT,PSMA3,PSMD1,GDNF,YWHAB,FGG,SPTBN1,RASAL2,BRAP,PSMB7,FGF1,SHC1,PSMD14,FGF3,NRAS,IL3,PSMB10,DUSP10,PSMD12,FGFR1,PDGFRB,IRS1,MIR5004,SEM1,JAK2,PSMB1,RASGRF1,PSMB3,KLB,DUSP16,GFRA4,KSR2,DAB2IP,FN1,SOS1,SRC,AKAP9,PSMA7,CSK,DUSP6,NRG1,PTPRA,GFRA3,RASGRP4,FGFR4,DUSP5,RASA2,SPTAN1,PSMA5,DUSP7,ITGB3,FGFR2,PSMC4,PPP2CA,PSMA6,NF1,FRS3,PSMF1,PSMB9,FGF20,PSMC2,IQGAP1,KSR1,FGF2,PTK2,BRAF,RASAL3,KBTBD7,UBA52 R-HSA-180336 |SHC1 events in EGFR signaling |0.000527745412319241|-7.5468965641789 |245 |134 |0.0294829482948295 |4545 |10287 |ARRB1,RASAL1,PSMB4,KITLG,PDGFA,TEK,CALM1,ERBB3,PSME4,PDGFRA,JAK1,PSMD7,PSMD3,NEFL,BTC,HBEGF,KRAS,MAP2K1,PPP2R5A,NRG4,CAMK2D,GRB2,CAMK2A,VWF,DUSP1,UBB,SPTB,PSMA1,PPP5C,FYN,RASGRP3,ERBB2,MAPK1,FGB,NRTN,CAMK2G,SPRED1,PSMB8,KL,SHC3,RANBP9,RASGRF2,MARK3,VCL,UBC,PSMB11,FRS2,DUSP9,SPRED2,GRIN2A,EGF,CALM2,RAPGEF2,RAF1,PSMB5,RASA3,FGF10,FGA,PPP2R1B,FGFR3,FGF9,KIT,PEBP1,FGF19,SYNGAP1,CAMK2B,RASAL2,BRAP,PSMB7,SPTBN1,FGF1,SHC1,PSMA3,FGG,PSMD1,GDNF,YWHAB,NRAS,PSMB10,IL3,FGF3,PSMD14,PDGFRB,IRS1,FGFR1,DUSP10,PSMD12,FN1,SRC,AKAP9,SOS1,PSMB1,RASGRF1,MIR5004,JAK2,SEM1,KSR2,DAB2IP,KLB,PSMB3,GFRA4,DUSP16,GFRA3,RASGRP4,FGFR4,NRG1,PTPRA,PSMA7,CSK,DUSP6,PSMA5,DUSP7,DUSP5,SPTAN1,RASA2,PPP2CA,PSMA6,PSMB9,PSMF1,NF1,FRS3,ITGB3,FGFR2,PSMC4,BRAF,PTK2,RASAL3,FGF2,UBA52,KBTBD7,FGF20,PSMC2,KSR1,IQGAP1 R-HSA-179812 |GRB2 events in EGFR signaling |0.000527745412319241|-7.5468965641789 |245 |134 |0.0294829482948295 |4545 |10287 |PSMA5,DUSP7,DUSP5,SPTAN1,RASA2,GFRA3,RASGRP4,FGFR4,PTPRA,NRG1,PSMA7,DUSP6,CSK,BRAF,PTK2,RASAL3,FGF2,UBA52,KBTBD7,PSMC2,FGF20,KSR1,IQGAP1,PPP2CA,PSMA6,PSMF1,PSMB9,NF1,FRS3,ITGB3,FGFR2,PSMC4,NRAS,IL3,PSMB10,FGF3,PSMD14,RASAL2,BRAP,PSMB7,SPTBN1,FGF1,SHC1,PSMA3,FGG,PSMD1,GDNF,YWHAB,FN1,SRC,AKAP9,SOS1,RASGRF1,PSMB1,MIR5004,JAK2,SEM1,KSR2,DAB2IP,KLB,PSMB3,DUSP16,GFRA4,PDGFRB,IRS1,FGFR1,DUSP10,PSMD12,FRS2,DUSP9,SPRED2,GRIN2A,EGF,CALM2,KL,SHC3,RANBP9,MARK3,RASGRF2,UBC,VCL,PSMB11,FGA,PPP2R1B,FGFR3,FGF9,KIT,PEBP1,FGF19,SYNGAP1,CAMK2B,RAPGEF2,RAF1,PSMB5,RASA3,FGF10,PSME4,PDGFRA,PSMD7,JAK1,PSMD3,NEFL,HBEGF,BTC,KRAS,MAP2K1,PPP2R5A,NRG4,CAMK2D,GRB2,ARRB1,RASAL1,PSMB4,KITLG,PDGFA,TEK,ERBB3,CALM1,FYN,RASGRP3,ERBB2,MAPK1,FGB,NRTN,CAMK2G,SPRED1,PSMB8,CAMK2A,VWF,DUSP1,UBB,SPTB,PSMA1,PPP5C R-HSA-71291 |Metabolism of amino acids and derivatives |0.000629015524750857|-7.37135461992954|361 |190 |0.0418041804180418 |4545 |10287 |BCAT1,PSMD3,PSMD7,RPL34,AGXT2,PSME4,ETHE1,HNMT,ASL,OTC,RPS3A,GCLC,PAH,RPS13,RPS15A,OGDH,GATM,PSMB4,ALDH4A1,PDHX,RPL24,PAPSS2,SLC6A12,KYAT1,SERINC5,RPS9,SECISBP2,SLC25A10,RPL9,AGXT,ASRGL1,RPS19,RPS20,GAMT,DDC,PSMB8,RPL13A,RPL38,SCLY,KYNU,ALDH7A1,HDC,RPS4Y2,PIPOX,PSMA1,RPS16,RPS24,MTR,SARS,OAT,RPL13,RPL36,ACMSD,IARS,AMD1,GPT2,IDO2,RPL15,PSTK,MARS,ADI1,PSMB11,TXNRD1,GOT2,RPL26,SLC25A21,GCSH,OCA2,OAZ2,SLC7A5,DUOX2,SAT1,GNMT,HPD,OAZ1,ENOPH1,UROC1,GSR,ASPG,MIR6805,PSMB5,GCLM,SMS,RPL18A,PSMB10,PHYKPL,DCT,DBT,ASNS,NMRAL1,PSMD14,SQOR,AMDHD1,AIMP2,CTH,AHCY,GOT1,SLC5A5,RPL19,PSMB7,ASS1,KYAT3,BCAT2,EEF1E1,PSMD1,LARS,PSMA3,TAT,IYD,RPS5,SMOX,SLC3A2,GLS,AASS,AADAT,HAAO,PSMB3,PSMB1,SEM1,PAPSS1,PYCR2,RPL23,QDPR,RPL32,ASMT,NDUFAB1,PSMD12,SERINC2,CKB,AFMID,FAH,AZIN2,RPL5,PSAT1,RPL22L1,PSMA5,HIBADH,PSPH,RPL12,DIO2,RPL21,RPS21,PYCR1,RPL23A,GADL1,BCKDHB,SLC6A7,RPS11,CNDP2,RPL10A,PSMA7,DLST,SERINC3,RPL31,RPS27,GLDC,EPRS,GRHPR,CPS1,UBA52,SLC25A15,IVD,DIO1,GPT,ARG1,RPLP1,SLC6A11,MTRR,MTAP,PNMT,PSMC2,RPS15,PSMB9,PSMF1,HGD,AANAT,ALDH18A1,PSMA6,RPLP2,PHGDH,TPH2,AIMP1,GLS2,CSAD,PSMC4,MAT1A,AGMAT,HAL,TST,ACADSB R-HSA-170968 |Frs2-mediated activation |0.000648879971540201|-7.34026280206207|250 |136 |0.0299229922992299 |4545 |10287 |CAMK2G,NRTN,SPRED1,PSMB8,ERBB2,RASGRP3,FYN,FGB,MAPK1,UBB,PPP5C,PSMA1,SPTB,DUSP1,VWF,CAMK2A,PPP2R5A,MAP2K1,KRAS,GRB2,CAMK2D,NRG4,PDGFRA,PSME4,BTC,HBEGF,NEFL,PSMD3,JAK1,PSMD7,TEK,PDGFA,ERBB3,CALM1,ARRB1,KITLG,PSMB4,RASAL1,CAMK2B,SYNGAP1,FGF19,FGF9,PPP2R1B,FGA,FGFR3,PEBP1,KIT,PSMB5,FGF10,RASA3,RAPGEF2,RAF1,GRIN2A,SPRED2,CALM2,EGF,FRS2,DUSP9,PSMB11,SHC3,RANBP9,KL,UBC,VCL,RASGRF2,MARK3,JAK2,SEM1,MIR5004,PSMB1,RASGRF1,DUSP16,GFRA4,PSMB3,KLB,KSR2,DAB2IP,FN1,SOS1,AKAP9,SRC,PSMD12,DUSP10,CRKL,FGFR1,PDGFRB,IRS1,PSMD14,FGF3,NRAS,PSMB10,IL3,PSMA3,YWHAB,PSMD1,GDNF,FGG,SPTBN1,PSMB7,RASAL2,BRAP,SHC1,FGF1,FGF20,PSMC2,IQGAP1,KSR1,FGF2,RASAL3,PTK2,BRAF,KBTBD7,UBA52,FGFR2,ITGB3,PSMC4,PSMA6,PPP2CA,FRS3,NF1,PSMF1,PSMB9,DUSP5,RASA2,SPTAN1,PSMA5,DUSP7,CSK,DUSP6,PSMA7,PTPRA,NRG1,RAPGEF1,FGFR4,RASGRP4,GFRA3 R-HSA-881907 |Gastrin-CREB signalling pathway via PKC and MAPK |0.000700405656494898|-7.2638508814931 |443 |229 |0.0503850385038504 |4545 |10287 |RGS2,ARRB1,RGS3,KITLG,PSMB4,OXT,RASAL1,CHRM5,PDGFA,TEK,ERBB3,CALM1,UTS2R,PDGFRA,ANXA1,PSME4,NEFL,HBEGF,BTC,JAK1,PSMD7,PSMD3,MAP2K1,PPP2R5A,PLCB1,KRAS,ITPR1,GRB2,NRG4,MLNR,CAMK2D,DGKK,DUSP1,CAMK2A,VWF,CREB1,EDN2,KALRN,UBB,PPP5C,PSMA1,SPTB,PIK3R2,ERBB2,FYN,RASGRP3,MAPK1,GNGT2,FGB,AGTR1,GPR17,CAMK2G,NRTN,PROKR2,SPRED1,PSMB8,KL,DGKD,RANBP9,SHC3,TBXA2R,UBC,VCL,GRK5,MARK3,RASGRF2,PRKCD,PSMB11,NMB,PROK1,XCR1,PRKCH,FRS2,ADRA1D,DUSP9,GRIN2A,SPRED2,GNG10,RASGRP2,CCKAR,CALM2,EGF,RAPGEF2,SAA1,RAF1,LTB4R2,PSMB5,P2RY6,FGF10,AGT,RASA3,FGFR3,FGA,PPP2R1B,FGF9,XCL2,BDKRB2,PEBP1,PTGER1,LPAR6,KIT,SYNGAP1,CAMK2B,AVPR1A,FGF19,RPS6KA2,SPTBN1,RASAL2,BRAP,PSMB7,FGF1,SHC1,GAST,NMUR2,DGKI,PSMA3,PSMD1,GDNF,YWHAB,NPSR1,FGG,DGKQ,TACR1,NRAS,DGKA,RPS6KA1,EDN1,IL3,PSMB10,RGSL1,ABHD6,PSMD14,FGF3,PDGFRB,BDKRB1,GNG7,IRS1,F2RL3,GCGR,PIK3R3,CYSLTR2,HTR2B,ADRA1A,DUSP10,PSMD12,FGFR1,APP,DAGLB,FN1,DGKZ,KISS1,FFAR2,SOS1,SRC,AKAP9,MIR5004,HTR2A,JAK2,SEM1,GNRH1,P2RY2,RASGRF1,PSMB1,KLB,PSMB3,GFRA4,DUSP16,DAB2IP,KSR2,GNA14,PRKCA,OPN4,RASGRP4,GFRA3,FGFR4,GNB5,PSMA7,F2,CSK,DUSP6,NRG1,NMBR,PTPRA,TRIO,GNB4,PSMA5,MGLL,DUSP7,GNG4,DUSP5,DGKE,TRPC3,MLN,PLCB4,RASA2,SPTAN1,PPP2CA,PSMA6,NTSR2,NF1,FRS3,PSMF1,ITPR3,PSMB9,ITGB3,PRKCE,FGFR2,PMCH,PSMC4,PTGFR,LTB4R,FGF2,RPS6KA3,BRAF,PTK2,RASAL3,TACR2,KBTBD7,ABHD12,NPS,UBA52,PSMC2,FGF20,ITPR2,KNG1,IQGAP1,GHSR,PIK3R1,KSR1 R-HSA-8848021|Signaling by PTK6 |0.000746244659320206|-7.20045704997291|67 |43 |0.00946094609460946 |4545 |10287 |DAB2IP,SPRED1,SYNGAP1,MIR5004,CDK4,UBA52,CRK,CCND1,RASAL3,ARAP1,ELMO1,ARHGAP35,ERBB2,RASA3,NR3C1,BCAR1,UBB,EPAS1,NF1,HIF1A,KHDRBS2,SFPQ,EGF,NRG4,STAT3,RASA2,KRAS,SPRED2,HBEGF,BTC,NRAS,PTPN1,NRG1,RHOA,PXN,ERBB3,RASAL1,CCNE1,UBC,SOCS3,RASAL2,DOCK1,KHDRBS3 R-HSA-1839117|Signaling by cytosolic FGFR1 fusion mutants |0.000780198018241084|-7.1559628009602 |18 |15 |0.0033003300330033 |4545 |10287 |STAT3,CNTRL,GRB2,PIK3R1,GAB2,BCR,CPSF6,STAT5B,TRIM24,CUX1,ZMYM2,STAT5A,LRRFIP1,MYO18A,STAT1 R-HSA-187706 |Signalling to p38 via RIT and RIN |0.000813414936983337|-7.11426920102153|249 |135 |0.0297029702970297 |4545 |10287 |PSMB11,UBC,VCL,RASGRF2,MARK3,RANBP9,SHC3,KL,CALM2,EGF,GRIN2A,SPRED2,DUSP9,FRS2,FGF10,RASA3,PSMB5,RAF1,RAPGEF2,CAMK2B,SYNGAP1,FGF19,PEBP1,KIT,FGF9,FGA,PPP2R1B,FGFR3,CALM1,ERBB3,TEK,PDGFA,KITLG,PSMB4,RASAL1,ARRB1,GRB2,CAMK2D,NRG4,PPP2R5A,MAP2K1,KRAS,HBEGF,BTC,NEFL,PSMD3,JAK1,PSMD7,PDGFRA,PSME4,PPP5C,PSMA1,SPTB,UBB,DUSP1,VWF,CAMK2A,PSMB8,SPRED1,CAMK2G,NRTN,FGB,MAPK1,ERBB2,RASGRP3,FYN,CSK,DUSP6,PSMA7,PTPRA,NRG1,FGFR4,RASGRP4,GFRA3,RASA2,SPTAN1,DUSP5,DUSP7,PSMA5,PSMC4,FGFR2,ITGB3,FRS3,NF1,PSMF1,PSMB9,PSMA6,PPP2CA,RIT1,IQGAP1,KSR1,PSMC2,FGF20,KBTBD7,UBA52,FGF2,RASAL3,PTK2,BRAF,YWHAB,PSMD1,GDNF,FGG,PSMA3,SHC1,FGF1,SPTBN1,PSMB7,BRAP,RASAL2,PSMD14,FGF3,PSMB10,IL3,NRAS,PSMD12,DUSP10,FGFR1,IRS1,PDGFRB,GFRA4,DUSP16,PSMB3,KLB,KSR2,DAB2IP,JAK2,SEM1,MIR5004,RASGRF1,PSMB1,SOS1,AKAP9,SRC,FN1 R-HSA-1280215|Cytokine Signaling in Immune system |0.000822427224747407|-7.10325055978965|756 |376 |0.0827282728272827 |4545 |10287 |TRIM46,RANBP2,CAMK2G,MAPK1,BRWD1,FGB,CCR1,RASGRP3,BTRC,ERBB2,PIK3R2,NUP188,PTK2B,NUP210,IL23R,PPP5C,IFNAR1,STAT5B,ITGB1,NRG4,SQSTM1,STAT3,GRB2,KRAS,MAP2K1,PSMD7,TRIM26,JAK1,PSMD3,IL1B,HBEGF,ANXA1,MMP2,CXCL2,TNFRSF1A,PRKACA,BCL6,CALM1,ERBB3,PDGFA,IFIT3,IL34,BCL2L1,RASAL1,PSMB4,ARRB1,TAB1,SEH1L,CISH,RAE1,FGF19,CAMK2B,PEBP1,VEGFA,PPP2R1B,IL31RA,FGA,FGF9,RASA3,PSMB5,LYN,IL1R1,PTPN2,SAA1,TNFSF18,STAT1,HIF1A,STAT5A,EGF,NUP35,CCL19,IL7,CALM2,CD27,GAB2,ITGAX,GRIN2A,IL22RA1,GHR,CSF1,CSF1R,BIRC2,IKBKG,EIF4E3,PRKCD,IFITM1,PSMB11,IFNL1,CXCL8,RASGRF2,IRF9,VCL,CLCF1,KL,TRAF2,RANBP9,SHC3,KSR2,KLB,PSMB3,UBE2N,DUSP16,RASGRF1,JAK2,IL1A,CRK,SOCS2,KPNA3,SKP1,FN1,DUSP10,NUP85,PSMD12,TRAF3,FSCN1,IL9R,IFNGR2,ZEB1,MX1,STAT6,TOLLIP,IL3,PSMB10,MMP9,NRAS,IL6ST,HMOX1,IL17RE,PTPN1,TNFSF14,YWHAB,XAF1,LBP,IRF1,KPNB1,FGF1,SHC1,BRAP,PSMB7,IL20RB,SPTBN1,CDKN1A,PIK3R1,SMARCA4,IQGAP1,USP18,IRAK1,ADAR,LCN2,LGALS9,MCL1,PSMC2,FGF20,TNFSF4,IL22RA2,IRF4,CCND1,BRAF,RASAL3,IL12A,IL7R,TNFRSF11A,FBXW11,ALOX15,TAB2,ITGB3,UBE2V1,IFI30,EDA,SPTAN1,EIF4A3,UBE2E1,RORA,JUNB,PTPN11,PSMA5,HIST1H3J,IFNLR1,YWHAZ,TXLNA,IL10RB,EIF4G2,EGR1,HIST1H3C,TRIM25,GFRA3,RASGRP4,FGFR4,EIF4E2,IFITM2,RAPGEF1,PRLR,IFNGR1,SOCS1,OPRM1,TRIM2,PELI1,PSMB8,SPRED1,NRTN,TRIM29,IL1RAP,TRIM35,MAP3K8,FYN,BIRC3,SPTB,PSMA1,UBB,NOD2,IL33,CAMK2A,VWF,POU2F1,DUSP1,CAMK2D,BATF,FASLG,TYK2,MX2,IL1RL2,PPP2R5A,NDN,NEFL,BTC,RNASEL,PSME4,ISG20,PDGFRA,NUP93,NFKB1,TEK,HLA-DPA1,NEDD4,KITLG,LIFR,CUL1,ADAM17,TRIM62,IL23A,LAMA5,IL9,SYNGAP1,IL4R,HSP90AA1,YES1,KIT,FGFR3,EIF4G3,FGF10,NUP205,IL6R,RAF1,RAPGEF2,NUP214,SPRED2,NUP42,DUSP9,EDAR,IL15,PIM1,FOS,FRS2,IL19,CD36,NUP58,CD40,MARK3,MAP3K14,BCL2,UBC,POMC,TRIM8,DAB2IP,MAOA,GFRA4,PSMB1,EIF4E,BST2,MIR5004,LTBR,FLNB,SEM1,BLNK,SRC,AKAP9,KPNA7,SOS1,IL12RB1,KPNA1,RHOU,FGFR1,OSMR,CRKL,IL13,CCL3L3,IRAK2,PIK3R3,IRS1,CSF3R,STX4,CIITA,PDGFRB,FGF3,TAB3,PSMD14,RIPK2,ITGB2,NFKB2,CCL20,IL32,RORC,FGG,PSMD1,GDNF,PSMA3,INPP5D,KPNA2,NOD1,MIR718,ITGAM,NUP43,RASAL2,ISG15,PPM1B,KSR1,MAP2K6,SP100,PIK3CB,IL1R2,MAP3K3,IFNL2,UBA52,TRIM14,KBTBD7,TRIM31,PTK2,EDARADD,FGF2,IL1RN,PSMC4,OSM,FGFR2,GBP6,IP6K2,PSMF1,PSMB9,TNFSF8,NF1,FRS3,PPP2CA,F13A1,PSMA6,EIF4A1,RASA2,FOXO3,IFI35,DUSP5,HSPA8,CD80,SAMHD1,DUSP7,STX1A,IL27,IRF2,PTPRA,NRG1,IRF8,PIAS1,DDX58,PSMA7,CSK,DUSP6,CEBPD,ICAM1,SOCS3 R-HSA-166054 |Activated TLR4 signalling |0.000845133857546287|-7.07601553185546|115 |68 |0.014961496149615 |4545 |10287 |MAPK1,ATF1,BTRC,SKP1,MAP2K7,BIRC3,MAP3K8,UBE2N,MAP2K3,MAPKAPK3,PELI1,CREB1,TRAF3,LY96,JUN,APP,IRAK2,NOD2,UBB,RPS6KA1,NFKB2,TLR6,TAB3,MAP2K1,RIPK2,CUL1,MIR718,RPS6KA2,MEF2A,TAB1,NOD1,NFKBIA,NFKB1,RIPK1,UBA52,RPS6KA3,PPP2R1B,MAP2K6,NFKBIB,TANK,IRAK1,DUSP3,SAA1,PPP2CA,UBE2V1,TAB2,TBK1,FBXW11,MAPKAPK2,DUSP7,CASP8,MAP3K1,BIRC2,FOS,SARM1,PTPN11,MAPK14,UBC,UBE2D1,SOCS1,DUSP6,CD14,IKBKG,AGER,UBE2D3,ECSIT,CD36,HMGB1 R-HSA-73923 |Lipid digestion, mobilization, and transport |0.000845133857546287|-7.07601553185546|115 |68 |0.014961496149615 |4545 |10287 |PPP1CC,APOA4,NR1H2,ANGPTL3,SAR1B,NR1H3,VLDLR,SH3KBP1,APOC3,CIDEC,ABCG5,APOA1,PRKACA,PCSK6,LDLR,LMF1,CREB3L3,ALB,NCEH1,SOAT2,PLIN1,LCAT,LIPG,APOC1,LIPE,MBTPS2,SCARB1,AP2B1,FYN,SOAT1,PLTP,HILPDA,LIPH,CETP,P4HB,AP2A1,AP2M1,HDLBP,MYLIP,FABP1,APOC2,FURIN,MBTPS1,APOA2,CAV1,LIPM,A2M,ABCA1,LIPA,DAB1,CIDEA,RELN,MGLL,FGF21,ANGPTL8,FITM2,ABCG8,LDLRAP1,MIR6886,AP2S1,PCSK9,APOA5,AMN,LIPC,HSD17B13,AP2A2,PPP1CB,APOB R-HSA-1852241|Organelle biogenesis and maintenance |0.000875488358609412|-7.04072870317496|340 |179 |0.0393839383938394 |4545 |10287 |DYNC1I2,CEP152,CLASP1,CEP72,NR1D1,MRPL14,PCNT,GFM2,IFT22,CCT5,MRPS17,IFT172,IFT20,MRPL55,MRPL46,HSP90AA1,POLRMT,PLK4,ODF2,MRPL22,MRPS16,PRKAG1,PCM1,NCOA1,RPGRIP1L,MRPS18A,CEP164,YWHAG,NPHP1,RP2,CEP97,TSFM,TCTN1,NDE1,MKKS,NCOA2,EXOC7,MARK4,IFT43,NEDD1,MRPS27,PPARGC1B,MAPK14,TBL1X,IFT80,CRTC3,RAB11A,IQCB1,TRAF3IP1,SCLT1,CREB1,IFT122,RAB11FIP3,DCTN1,DYNLRB2,CCP110,CEP63,PPARA,MRPL3,CKAP5,CRTC1,MAPRE1,MRPS21,LZTFL1,HAUS3,MRPS28,MRPS36,PPARGC1A,CHCHD1,MTIF2,CEP89,CYS1,IFT52,EXOC6,CEP192,DCTN2,RHO,SSBP1,NINL,DYNC1H1,NEK2,PRKACA,CC2D2A,TUBB,MRPL19,CEP76,PTCD3,TTC8,TNPO1,CEP78,MRPL33,IFT81,MRPS10,CEP57,SSTR3,DYNLRB1,MRPS25,PRKAB2,CSNK1E,SMARCD3,KIF3B,KIF17,BBS1,CETN2,ESRRA,MTIF3,MRPL16,HAUS4,WDR60,MRPL35,BBS12,SEPTIN2,ASAP1,HELZ2,CRTC2,IFT88,BBS9,MKS1,TMEM216,PRKAG2,MRPS23,POLG2,NRF1,KIF3C,MRPL30,MRPL15,TTBK2,MRPL2,MRPL4,TTC30A,MRPL18,HAUS6,CARM1,BBS2,CNGA2,RXRA,CHD9,MRPS9,MRPL1,MRPS33,MRPL44,TFAM,CNTRL,MRPS18B,CNGB1,AKAP9,TFB2M,CYCS,CLUAP1,IFT57,MRPL13,CREBBP,ALAS1,MRPS5,PRKAB1,CCT2,CDK5RAP2,CCT3,MRPS15,MRPL48,MED1,DYNC2LI1,MRPL53,MIR484,CEP250,EXOC8,CEP162,MRPS35,CEP83,MRPL17,MRPL10,MRPL34,PLK1,RAB3IP,MRPS14,MRPL54,TFB1M,TTC21B,CEP70 R-HSA-3322077|Glycogen synthesis |0.000888259928274354|-7.02624614578324|15 |13 |0.00286028602860286 |4545 |10287 |PGM2,GBE1,GYS2,PGM1,UBA52,UBC,UBB,GYG1,PPP1R3C,GYS1,EPM2A,UGP2,NHLRC1 R-HSA-1368082|RORA activates gene expression |0.00091880919559173 |-6.99243207893676|28 |21 |0.00462046204620462 |4545 |10287 |SREBF1,CPT1A,ARNTL,NPAS2,NR1D1,MED1,NCOA1,SMARCD3,CHD9,RXRA,TBL1X,HELZ2,PPARGC1A,CARM1,CREBBP,NCOA2,RORA,EP300,NRIP1,SIRT1,PPARA R-HSA-2730905|Role of LAT2/NTAL/LAB on calcium mobilization |0.000941855461755855|-6.96765873278715|131 |76 |0.0167216721672167 |4545 |10287 |AGO2,CASP9,PIP5K1A,PPP2CA,FGF10,LYN,GSK3A,FGFR2,PRR5,KIT,FGF9,FGF2,FGFR3,PPP2R1B,PIK3R1,CDKN1A,PIK3CB,AKT1S1,FGF19,FGF20,FGFR4,PHLPP1,NR4A1,TRIB3,KL,TSC2,RPS6KB2,NRG1,GSK3B,CD80,PTPN11,FRS2,EGF,INSR,PIP5K1B,FOXO3,GAB2,PIK3R3,TNRC6A,CREB1,MTOR,IRS1,PIK3AP1,PDGFRB,FGFR1,SRC,MAPK1,SOS1,FYN,LAT2,PIK3R2,ERBB2,PHLPP2,TNRC6B,RICTOR,PIP4K2A,KLB,SHC1,KITLG,FGF1,AGO3,ERBB3,PDGFA,CD28,MAPKAP1,HBEGF,BTC,TNRC6C,PDGFRA,MDM2,PDPK1,NRG4,FGF3,GRB2,AKT3,PPP2R5A R-HSA-383280 |Nuclear Receptor transcription pathway |0.000977976929502628|-6.93002447767331|51 |34 |0.00748074807480748 |4545 |10287 |NR1D2,NR1H2,NR6A1,MED1,NR4A2,RXRB,NR1H3,NR4A1,NR0B2,THRA,NR2F1,RORC,RORA,RARA,NR3C1,VDR,ESRRA,RARB,NR1H4,NR1D1,NR3C2,RARG,PPARG,RXRA,ESRRB,ESR1,PPARD,NR5A2,HNF4G,HNF4A,NR2F6,NR5A1,PPARA,NRBF2 R-HSA-6788656|Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism |0.00110670318497235 |-6.8063697867973 |44 |30 |0.0066006600660066 |4545 |10287 |OGDH,AMDHD1,HDC,HGD,ALDH7A1,ALDH4A1,QDPR,KYAT3,UROC1,PIPOX,IDO2,TAT,DLST,AFMID,HAL,KYAT1,SLC25A21,FAH,SLC3A2,ASRGL1,PHYKPL,AASS,SLC7A5,HAAO,AADAT,HNMT,ACMSD,PAH,KYNU,HPD R-HSA-2172127|DAP12 interactions |0.00120945241610064 |-6.7175875704817 |371 |193 |0.0424642464246425 |4545 |10287 |PSMC4,PRKCE,ITGB3,PRR5,FGFR2,GSK3A,PSMB9,ITPR3,PSMF1,NF1,FRS3,PPP2CA,PIP5K1A,PSMA6,CDKN1A,KSR1,PIK3R1,IQGAP1,ADCY8,PIK3CB,PSMC2,FGF20,ITPR2,UBA52,KBTBD7,BRAF,PTK2,RASAL3,FGF2,PTPRA,NRG1,RPS6KB2,PSMA7,DUSP6,CSK,GFRA3,RASGRP4,FGFR4,PRKCA,SPTAN1,RASA2,FOXO3,DUSP5,CD80,DUSP7,PTPN11,PSMA5,FGFR1,DUSP10,PSMD12,PIK3R3,TNRC6A,IRS1,PDGFRB,KSR2,DAB2IP,PIP4K2A,RICTOR,PSMB3,KLB,TYROBP,GFRA4,DUSP16,PSMB1,RASGRF1,ADCY4,MIR5004,JAK2,SEM1,ADCY1,SRC,AKAP9,SOS1,FN1,TREM1,FGG,PSMD1,GDNF,YWHAB,PSMA3,CD28,FGF1,SHC1,BRAP,RASAL2,PSMB7,AGO3,SPTBN1,FGF3,MDM2,PSMD14,ADCY7,AKT3,IL3,AHCYL1,MAPKAP1,PSMB10,NRAS,RASA3,FGF10,PSMB5,ADCY9,AGO2,RAF1,VAV2,CASP9,RAPGEF2,AKT1S1,FGF19,SYNGAP1,PLCG2,CAMK2B,KIT,PRKAR1A,PEBP1,FGA,PPP2R1B,FGFR3,FGF9,GSK3B,PSMB11,PRKCD,PHLPP1,MARK3,RASGRF2,ADCY3,UBC,VCL,NR4A1,KL,TSC2,TRIB3,RANBP9,SHC3,EGF,CALM2,INSR,PIP5K1B,GRIN2A,SPRED2,DUSP9,FRS2,SPTB,PSMA1,PPP5C,UBB,CREB1,MTOR,CAMK2A,PIK3AP1,VAV3,CAMK4,VWF,DUSP1,TNRC6B,PHLPP2,SPRED1,PSMB8,KLRK1,NRTN,CAMK2G,MAPK1,FGB,FYN,RASGRP3,ERBB2,PIK3R2,CALM1,ERBB3,PDGFA,TEK,RASAL1,KITLG,PSMB4,ARRB1,PDPK1,NRG4,CAMK2D,ITPR1,GRB2,KRAS,MAP2K1,PPP2R5A,PSMD7,JAK1,PSMD3,NEFL,BTC,HBEGF,PSME4,PDGFRA,TNRC6C,PRKACA R-HSA-180292 |GAB1 signalosome |0.0012497777644267 |-6.68478953193281|128 |74 |0.0162816281628163 |4545 |10287 |TNRC6A,PIK3R3,CREB1,MTOR,IRS1,PIK3AP1,PDGFRB,FGFR1,PAG1,SRC,MAPK1,FYN,ERBB2,PIK3R2,TNRC6B,RICTOR,PIP4K2A,PHLPP2,KLB,KITLG,FGF1,AGO3,ERBB3,PDGFA,CD28,MAPKAP1,BTC,HBEGF,TNRC6C,PDGFRA,MDM2,NRG4,FGF3,PDPK1,GRB2,PPP2R5A,AKT3,AGO2,CASP9,PIP5K1A,PPP2CA,FGF10,FGFR2,GSK3A,PRR5,KIT,FGF9,PPP2R1B,FGFR3,FGF2,PIK3R1,CDKN1A,AKT1S1,PIK3CB,FGF19,FGF20,FGFR4,PHLPP1,NR4A1,TRIB3,KL,TSC2,RPS6KB2,PXN,NRG1,CSK,GSK3B,CD80,PTPN11,FRS2,EGF,INSR,PIP5K1B,FOXO3 R-HSA-975138 |TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |0.00126302540912909 |-6.67424531774086|91 |55 |0.0121012101210121 |4545 |10287 |MAP2K7,MAP3K8,PPP2R1B,BTRC,RPS6KA3,SKP1,UBA52,ATF1,MAPK1,TLR9,NFKBIB,IRAK1,MAP2K6,PELI1,MAP2K3,UBE2N,MAPKAPK3,PPP2CA,DUSP3,CREB1,SAA1,UBB,NOD2,TAB2,FBXW11,UBE2V1,IRAK2,JUN,APP,LY96,FOS,MAP3K1,NFKB2,MAPKAPK2,DUSP7,RPS6KA1,RIPK2,MAP2K1,MAPK14,TAB3,MEF2A,TAB1,RPS6KA2,MIR718,CUL1,UBC,ECSIT,HMGB1,NFKB1,NOD1,NFKBIA,IKBKG,AGER,CD14,DUSP6 R-HSA-181438 |Toll Like Receptor 2 (TLR2) Cascade |0.00133061771612937 |-6.62211199635359|95 |57 |0.0125412541254125 |4545 |10287 |SAA1,DUSP3,CREB1,PPP2CA,APP,JUN,LY96,FBXW11,NOD2,TAB2,UBB,IRAK2,UBE2V1,ATF1,UBA52,MAPK1,MAP3K8,MAP2K7,BTRC,PPP2R1B,SKP1,RPS6KA3,MAP2K6,PELI1,MAPKAPK3,MAP2K3,UBE2N,IRAK1,NFKBIB,MIR718,UBC,CUL1,MEF2A,TAB1,SOCS1,RPS6KA2,IKBKG,AGER,CD14,DUSP6,NFKB1,HMGB1,CD36,ECSIT,NFKBIA,NOD1,MAP3K1,NFKB2,RPS6KA1,MAPKAPK2,DUSP7,TLR6,FOS,MAPK14,TAB3,RIPK2,MAP2K1 R-HSA-168188 |Toll Like Receptor TLR6:TLR2 Cascade |0.00133061771612937 |-6.62211199635359|95 |57 |0.0125412541254125 |4545 |10287 |PPP2CA,SAA1,DUSP3,CREB1,FBXW11,NOD2,TAB2,UBB,UBE2V1,IRAK2,JUN,APP,LY96,MAP3K8,MAP2K7,BTRC,SKP1,RPS6KA3,PPP2R1B,ATF1,UBA52,MAPK1,IRAK1,NFKBIB,MAP2K6,PELI1,MAPKAPK3,MAP2K3,UBE2N,TAB1,MEF2A,SOCS1,RPS6KA2,MIR718,UBC,CUL1,HMGB1,NFKB1,CD36,ECSIT,NFKBIA,NOD1,AGER,IKBKG,DUSP6,CD14,TLR6,FOS,NFKB2,MAP3K1,RPS6KA1,MAPKAPK2,DUSP7,RIPK2,MAP2K1,MAPK14,TAB3 R-HSA-166058 |MyD88:Mal cascade initiated on plasma membrane |0.00133061771612937 |-6.62211199635359|95 |57 |0.0125412541254125 |4545 |10287 |DUSP3,CREB1,SAA1,PPP2CA,LY96,JUN,APP,UBE2V1,IRAK2,NOD2,UBB,TAB2,FBXW11,MAPK1,UBA52,ATF1,PPP2R1B,BTRC,RPS6KA3,SKP1,MAP2K7,MAP3K8,UBE2N,MAP2K3,MAPKAPK3,MAP2K6,PELI1,NFKBIB,IRAK1,CUL1,UBC,MIR718,SOCS1,RPS6KA2,TAB1,MEF2A,DUSP6,CD14,IKBKG,AGER,NOD1,NFKBIA,ECSIT,CD36,HMGB1,NFKB1,DUSP7,MAPKAPK2,RPS6KA1,NFKB2,MAP3K1,FOS,TLR6,TAB3,MAPK14,MAP2K1,RIPK2 R-HSA-168179 |Toll Like Receptor TLR1:TLR2 Cascade |0.00133061771612937 |-6.62211199635359|95 |57 |0.0125412541254125 |4545 |10287 |UBC,CUL1,MIR718,RPS6KA2,SOCS1,MEF2A,TAB1,DUSP6,CD14,AGER,IKBKG,NFKBIA,NOD1,HMGB1,NFKB1,CD36,ECSIT,RPS6KA1,DUSP7,MAPKAPK2,NFKB2,MAP3K1,FOS,TLR6,TAB3,MAPK14,MAP2K1,RIPK2,SAA1,DUSP3,CREB1,PPP2CA,LY96,JUN,APP,UBE2V1,IRAK2,FBXW11,UBB,NOD2,TAB2,MAPK1,ATF1,UBA52,SKP1,PPP2R1B,RPS6KA3,BTRC,MAP3K8,MAP2K7,MAPKAPK3,MAP2K3,UBE2N,PELI1,MAP2K6,IRAK1,NFKBIB R-HSA-168643 |Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |0.00137099156934562 |-6.59222102769467|48 |32 |0.00704070407040704 |4545 |10287 |CARD9,RIPK2,MEFV,PANX1,TAB3,MAPK14,BIRC2,ITCH,CASP8,NOD1,BCL2L1,P2RX7,HSP90AB1,IKBKG,NLRC4,TAB1,BCL2,MIR718,IRAK1,MAPK13,UBE2N,MAP2K6,BIRC3,CASP4,IRAK2,UBE2V1,NOD2,TAB2,SUGT1,APP,TXN,CASP9 R-HSA-5627117|RHO GTPases Activate ROCKs |0.00148870444725762 |-6.50984903574266|17 |14 |0.00308030803080308 |4545 |10287 |MYH9,MYL6,ROCK1,PPP1R12B,MYH11,MYL12B,PPP1CB,ROCK2,RHOA,RHOB,LIMK2,MYH10,MYL9,MYH14 R-HSA-6802949|Signaling by RAS mutants |0.0015029165341879 |-6.50034770256242|50 |33 |0.00726072607260726 |4545 |10287 |FGB,PEBP1,MAPK1,SRC,FN1,FGA,RASAL3,BRAF,IQGAP1,KSR1,KSR2,DAB2IP,JAK2,MIR5004,SYNGAP1,NF1,RAF1,VWF,RASA3,ITGB3,NRAS,RASA2,MAP2K1,KRAS,VCL,RASAL1,MARK3,BRAP,ARRB1,RASAL2,YWHAB,CSK,FGG R-HSA-6785807|Interleukin-4 and 13 signaling |0.0015421938759418 |-6.47454928156163|111 |65 |0.0143014301430143 |4545 |10287 |CDKN1A,PIK3R1,LCN2,MCL1,IL23A,LAMA5,IRF4,VEGFA,CCND1,IL4R,HSP90AA1,FGF2,IL12A,OSM,ALOX15,SAA1,IL6R,F13A1,HIF1A,STAT1,FOXO3,ITGAX,JUNB,RORA,HSPA8,FOS,PIM1,ICAM1,CEBPD,CD36,BCL2,SOCS3,POMC,CXCL8,SOCS1,OPRM1,MAOA,JAK2,IL1A,FN1,IL13,RHOU,IL23R,ITGB1,FSCN1,POU2F1,STAT3,ZEB1,FASLG,BATF,STAT6,TYK2,MMP9,IL1B,RORC,JAK1,NDN,ITGB2,HMOX1,ANXA1,MMP2,BCL6,LBP,BCL2L1,ITGAM R-HSA-75109 |Triglyceride Biosynthesis |0.00157401692406713 |-6.45412437677845|82 |50 |0.011001100110011 |4545 |10287 |AGPAT4,LHX4-AS1,ACSL5,GK,GPAT3,ACOT12,ACOT1,ACACA,HACD2,GPAT2,ACOT7,ACOT11,ACSL3,MIR639,ACSBG1,ELOVL6,ACSBG2,ACSL6,ACSL4,LPIN1,ACOT2,GPAT4,ACSF3,GPD1,GPAM,FASN,MOGAT1,DBI,SLC25A1,ELOVL3,ACLY,LPIN2,AGPAT1,ACOT13,LCLAT1,PCTP,DGAT1,ACSF2,TECR,LPCAT1,MIR6848,HACD1,ELOVL5,ACBD6,MOGAT2,AGPAT3,GPD1L,LPIN3,AGPAT2,ACSL1 R-HSA-8849471|PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |0.00158438680840452 |-6.44755781817611|27 |20 |0.0044004400440044 |4545 |10287 |RASAL2,DOCK1,RASAL1,NF1,BCAR1,RHOA,PXN,RASA3,NRAS,RASAL3,ARHGAP35,ELMO1,CRK,KRAS,SYNGAP1,SPRED2,MIR5004,DAB2IP,SPRED1,RASA2 R-HSA-400685 |Sema4D in semaphorin signaling |0.00158438680840452 |-6.44755781817611|27 |20 |0.0044004400440044 |4545 |10287 |SEMA4D,ROCK2,PLXNB1,ERBB2,ARHGAP35,MYH10,RHOG,MYL9,MYL6,ROCK1,MYH9,MYH11,MYL12B,RND1,RHOA,CDC42,RHOB,LIMK2,ARHGEF12,MYH14 R-HSA-381340 |Transcriptional regulation of white adipocyte differentiation |0.00171780009219578 |-6.3667108229613 |88 |53 |0.0116611661166117 |4545 |10287 |FAM120B,PPARGC1A,CREBBP,MED23,HELZ2,MED9,MED29,THRAP3,MED27,PPARA,NCOR2,ZNF638,CDK4,MED13,CDK8,CCND3,CEBPB,MED20,KLF5,NCOA3,LEP,SREBF1,PLIN1,NR2F2,CHD9,PPARG,KLF4,RXRA,MED4,SMARCD3,MED26,CEBPA,CARM1,ZNF467,NCOA2,MED8,TBL1X,MED15,MED28,WNT10B,EP300,PCK1,CD36,MED1,NFKB1,CEBPD,MED11,MED30,MED18,SREBF2,SLC2A4,NCOA1,MED13L R-HSA-2219528|PI3K/AKT Signaling in Cancer |0.00176146040642509 |-6.34161203762828|90 |54 |0.0118811881188119 |4545 |10287 |KL,TSC2,NR4A1,FGF1,KITLG,FGFR4,CD28,PDGFA,GSK3B,NRG1,RPS6KB2,ERBB3,PDGFRA,FRS2,PTPN11,CD80,HBEGF,BTC,MAPKAP1,AKT3,FOXO3,GRB2,NRG4,PDPK1,FGF3,EGF,MDM2,PDGFRB,PIK3AP1,CASP9,IRS1,MTOR,CREB1,PIK3R3,PRR5,FGFR2,GSK3A,FGF10,FGFR1,FGFR3,FGF2,FGF9,ERBB2,PIK3R2,FYN,KIT,FGF20,FGF19,KLB,AKT1S1,PIK3CB,CDKN1A,PIK3R1,RICTOR R-HSA-2871837|FCERI mediated NF-kB activation |0.00215176412148787 |-6.14146725166414|79 |48 |0.0105610561056106 |4545 |10287 |CARD11,PSMB3,PSMB8,UBE2N,PSMB1,SEM1,PSMC2,UBA52,BTRC,SKP1,PSMA1,PSMC4,PSMD12,PSMB5,FBXW11,LYN,TAB2,UBB,UBE2V1,PSMF1,PSMB9,MALT1,PSMA6,PDPK1,PSMD14,TAB3,RASGRP2,PSMD7,PSMB10,PSMD3,PSMA5,PSME4,IKBKG,PSMD1,PSMA7,CDC34,NFKB1,PSMA3,NFKBIA,PSMB11,RASGRP4,BCL10,UBC,PSMB4,CUL1,TAB1,PSMB7,UBE2D1 R-HSA-193368 |Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |0.00216823302639542 |-6.13384271668105|24 |18 |0.00396039603960396 |4545 |10287 |SLC27A2,NR1H4,SLC27A5,ACOX2,AKR1C3,NCOA1,RXRA,AKR1C2,PTGIS,BAAT,NCOA2,HSD17B4,AKR1D1,CYP27A1,SCP2,AKR1C1,AMACR,CYP8B1 R-HSA-201451 |Signaling by BMP |0.00216823302639542 |-6.13384271668105|24 |18 |0.00396039603960396 |4545 |10287 |NOG,SMAD9,SKI,BMPR2,ACVR2A,ZFYVE16,BMPR1A,SMAD6,SMAD4,SMURF2,SMAD1,UBE2D3,FSTL1,SMURF1,SMAD5,UBE2D1,SMAD7,MIR198 R-HSA-5655302|Signaling by FGFR1 in disease |0.00218320526602723 |-6.12696117650489|38 |26 |0.00572057205720572 |4545 |10287 |GAB2,KRAS,FGF20,PIK3R1,STAT3,GRB2,NRAS,FGF2,FRS2,MYO18A,FGF9,SOS1,BCR,FGFR1,CNTRL,STAT1,STAT5A,LRRFIP1,TRIM24,ZMYM2,CUX1,STAT5B,CPSF6,FGF1,BAG4,ERLIN2 R-HSA-1839124|FGFR1 mutant receptor activation |0.00231925583736797 |-6.06650890451352|31 |22 |0.00484048404840484 |4545 |10287 |CNTRL,FGFR1,STAT5A,LRRFIP1,STAT1,FGF1,STAT5B,BAG4,CPSF6,ERLIN2,TRIM24,ZMYM2,CUX1,FGF20,GAB2,STAT3,GRB2,PIK3R1,FGF2,FGF9,MYO18A,BCR R-HSA-195258 |RHO GTPase Effectors |0.00253234919418909 |-5.97860787181229|294 |154 |0.0338833883388339 |4545 |10287 |LIMK2,SEH1L,NCKAP1,MYH14,ACTB,CALM1,SGO2,MYH10,ARPC5,NCK1,RCC2,PPP2R5A,HIST1H2BL,GRB2,CENPH,PDPK1,HIST1H4E,BUB1B,ITGB1,ACTG1,MYL6,MYH9,INCENP,NCF2,PPP1R12B,ABL1,CENPS,WASL,CKAP5,H2AFV,MAPK1,RANBP2,RANGAP1,MAPRE1,IQGAP3,NSL1,CENPU,PKN2,HIST1H2BH,CENPL,ABI2,YWHAG,PFN1,KNL1,HIST1H2BO,HIST1H4I,RHPN2,CDC20,NDE1,RHOD,ARPC2,KIF2B,NCOA2,CALM2,CENPC,WASF2,HIST1H4H,PAK3,AURKB,AHCTF1,NUDC,CLASP1,FMNL2,EVL,ROCK1,CYFIP2,PPP2R1B,PIK3C3,NOX3,DAAM1,KIF5B,KLC4,DIAPH1,ROCK2,NDEL1,CTNNB1,SEC13,HIST1H2BJ,NUP43,PPP1CC,PFN2,HIST1H4B,SPC24,HIST1H2AE,YWHAB,CDC42,MIR484,KLC2,KDM4C,ITGB3BP,ABI1,GOPC,PLK1,NOX1,XPO1,YWHAQ,MIR4738,NUP85,RHOB,RHOG,MYL9,H2AFZ,SRC,ARPC1B,HIST1H4D,KNTC1,ACTR2,KTN1,ARPC1A,CENPT,CDH1,HIST1H3C,PRC1,RPS27,MYH11,SKA1,CTNNA1,RHOA,YWHAZ,HIST1H3J,H2AFJ,HIST1H4K,CENPF,MAD1L1,RHOQ,CYFIP1,CYBA,FMNL3,IQGAP2,TAOK1,PAK2,PPP2CA,BUB1,DSN1,RHPN1,CLASP2,CLIP1,MYL12B,CENPA,BUB3,PTK2,MYLK,ACTR3,HIST1H2BC,ROPN1,MRTFA,PAK1,PPP1CB,SRF,IQGAP1,RTKN,WASF1,FMNL1,CTTN R-HSA-168181 |Toll Like Receptor 7/8 (TLR7/8) Cascade |0.00253451846176425 |-5.97775161589444|93 |55 |0.0121012101210121 |4545 |10287 |NFKB1,HMGB1,ECSIT,NFKBIA,NOD1,AGER,IKBKG,CD14,DUSP6,MEF2A,TAB1,RPS6KA2,MIR718,UBC,CUL1,RIPK2,MAP2K1,MAPK14,TAB3,FOS,NFKB2,MAP3K1,RPS6KA1,DUSP7,MAPKAPK2,FBXW11,TAB2,NOD2,UBB,IRAK2,UBE2V1,JUN,APP,LY96,PPP2CA,SAA1,DUSP3,CREB1,IRAK1,TLR9,NFKBIB,MAP2K6,PELI1,MAPKAPK3,UBE2N,MAP2K3,MAP3K8,MAP2K7,BTRC,RPS6KA3,SKP1,PPP2R1B,ATF1,UBA52,MAPK1 R-HSA-975155 |MyD88 dependent cascade initiated on endosome |0.00253451846176425 |-5.97775161589444|93 |55 |0.0121012101210121 |4545 |10287 |FOS,NFKB2,MAP3K1,RPS6KA1,MAPKAPK2,DUSP7,RIPK2,MAP2K1,MAPK14,TAB3,MEF2A,TAB1,RPS6KA2,MIR718,UBC,CUL1,NFKB1,HMGB1,ECSIT,NFKBIA,NOD1,IKBKG,AGER,DUSP6,CD14,MAP3K8,MAP2K7,PPP2R1B,RPS6KA3,BTRC,SKP1,ATF1,UBA52,MAPK1,IRAK1,NFKBIB,TLR9,MAP2K6,PELI1,MAPKAPK3,MAP2K3,UBE2N,PPP2CA,SAA1,CREB1,DUSP3,FBXW11,TAB2,NOD2,UBB,UBE2V1,IRAK2,APP,JUN,LY96 R-HSA-168138 |Toll Like Receptor 9 (TLR9) Cascade |0.0026171104477461 |-5.94568445237127|97 |57 |0.0125412541254125 |4545 |10287 |EEA1,SKP1,RPS6KA3,BTRC,PPP2R1B,MAP3K8,MAP2K7,PIK3C3,MAPK1,ATF1,UBA52,IRAK1,NFKBIB,TLR9,MAPKAPK3,UBE2N,MAP2K3,MAP2K6,PELI1,PPP2CA,SAA1,DUSP3,CREB1,IRAK2,UBE2V1,FBXW11,UBB,TAB2,NOD2,LY96,JUN,APP,FOS,RPS6KA1,DUSP7,MAPKAPK2,MAP3K1,NFKB2,MAP2K1,RIPK2,TAB3,MAPK14,RPS6KA2,MEF2A,TAB1,UBC,CUL1,MIR718,NFKBIA,NOD1,HMGB1,NFKB1,ECSIT,DUSP6,CD14,IKBKG,AGER R-HSA-389356 |CD28 co-stimulation |0.00269709816952484 |-5.9155788359598 |33 |23 |0.00506050605060506 |4545 |10287 |AKT3,PAK1,PAK3,GRB2,PDPK1,PAK2,RICTOR,PIK3R1,PIK3R2,MAP3K8,FYN,CD80,SRC,MAPKAP1,YES1,PRR5,CD28,LYN,CDC42,TRIB3,MTOR,PIK3R3,MAP3K14 R-HSA-76002 |Platelet activation, signaling and aggregation |0.00275538159223188 |-5.89419933699165|282 |148 |0.0325632563256326 |4545 |10287 |APOH,ADRA2C,ITPR3,SRGN,F13A1,OLA1,STXBP2,CLU,ITGB3,PRKCE,SELENOP,ADRA2A,ABHD12,SERPINA1,PIK3CG,PTK2,PIK3CB,PIK3R1,ITPR2,KNG1,IGF1,LGALS3BP,GNA14,RAB27B,SPARC,PRKCA,CSK,F2,RHOA,GNB5,MGLL,HSPA5,GNG4,ORM2,GNB4,YWHAZ,PTPN11,THBS1,TRPC3,DGKE,F2RL3,PIK3R3,PCYOX1L,GNG7,STX4,APP,RHOB,GNAI3,AHSG,RHOG,SOS1,CHID1,CRK,SRC,DGKZ,DAGLB,FN1,SERPINE1,LAMP2,CDC37L1,F5,JAK2,SHC1,GNAI1,TIMP3,FGG,CDC42,TEX264,DGKI,PROS1,IL3,PTPN1,DGKQ,DGKA,AKT3,ABHD6,RAF1,VAV2,HABP4,ORM1,ABCC4,IGF2,BCAR1,LYN,VEGFA,PPIA,PSAP,SCCPDH,FGA,GTPBP2,PLCG2,GNA12,VCL,SERPINA3,DGKD,TBXA2R,PRKCD,VEGFD,PFN1,ALDOA,CD36,PIK3R5,PRKCH,A2M,CALM2,MAPK14,QSOX1,EGF,MPL,CFD,GAB2,MIR6843,RASGRP2,GNG10,ANXA5,GP1BA,WDR1,GNAI2,VWF,VAV3,RAPGEF4,ALB,PHACTR2,FGB,GNGT2,MAPK1,LHFPL2,PIK3R2,PRKCZ,FYN,ACTN4,PECAM1,TGFB3,TF,ACTN1,CD9,ARRB1,SERPINF2,CALM1,SOD1,PDGFA,JAK1,FERMT3,APOA1,GRB2,ITPR1,DGKK,PDPK1 R-HSA-1433559|Regulation of KIT signaling |0.00281092362534341 |-5.87424215735093|16 |13 |0.00286028602860286 |4545 |10287 |KIT,YES1,SRC,KITLG,SOS1,SH2B2,FYN,PRKCA,SOCS1,SOCS6,GRB2,LYN,SH2B3 R-HSA-375165 |NCAM signaling for neurite out-growth |0.00287277930101787 |-5.85247532023783|276 |145 |0.0319031903190319 |4545 |10287 |FGF10,COL4A4,RASA3,PSMB5,RAF1,RAPGEF2,SYNGAP1,CAMK2B,FGF19,PEBP1,PRNP,KIT,PPP2R1B,FGA,FGFR3,FGF9,ST8SIA2,PSMB11,UBC,VCL,MARK3,RASGRF2,KL,RANBP9,SHC3,CALM2,EGF,SPRED2,GRIN2A,COL4A5,DUSP9,FRS2,PPP5C,SPTB,PSMA1,CACNB4,UBB,CREB1,DUSP1,CAMK2A,VWF,SPRED1,PSMB8,CAMK2G,NRTN,MAPK1,FGB,ERBB2,FYN,RASGRP3,CALM1,ERBB3,PDGFA,TEK,PSMB4,KITLG,RASAL1,ARRB1,GRB2,NRG4,CAMK2D,COL6A3,MAP2K1,PPP2R5A,KRAS,NEFL,HBEGF,BTC,PSMD7,JAK1,PSMD3,PDGFRA,PSME4,PSMC4,ITGB3,FGFR2,NF1,FRS3,PSMF1,PSMB9,PPP2CA,PSMA6,IQGAP1,KSR1,PSMC2,FGF20,KBTBD7,UBA52,FGF2,BRAF,PTK2,RASAL3,PSMA7,CSK,DUSP6,NRG1,PTPRA,GFRA3,RASGRP4,FGFR4,RASA2,SPTAN1,DUSP5,DUSP7,CACNA1D,PSMA5,DUSP10,PSMD12,CACNB3,FGFR1,COL9A2,IRS1,PDGFRB,KLB,PSMB3,GFRA4,DUSP16,DAB2IP,KSR2,MIR5004,JAK2,SEM1,PSMB1,RASGRF1,SOS1,SRC,AKAP9,FN1,PSMD1,GDNF,YWHAB,FGG,PSMA3,FGF1,SHC1,SPTBN1,RASAL2,BRAP,PSMB7,PSMD14,FGF3,IL3,PSMB10,COL9A3,NRAS R-HSA-5663220|RHO GTPases Activate Formins |0.00287558997550763 |-5.85149741691307|117 |67 |0.0147414741474147 |4545 |10287 |CENPT,CENPL,CENPU,RPS27,PFN1,KNL1,RHOA,SKA1,CDC20,CENPF,RHOD,MAD1L1,NDE1,FMNL3,KIF2B,AHCTF1,AURKB,TAOK1,CENPC,DSN1,BUB1,PPP2CA,NUDC,CLASP2,CLASP1,CLIP1,EVL,FMNL2,CENPA,PPP2R1B,BUB3,MRTFA,DAAM1,FMNL1,DIAPH1,SRF,SEH1L,NDEL1,NUP43,SEC13,SPC24,ACTB,PFN2,PPP1CC,CDC42,SGO2,MIR484,ITGB3BP,RCC2,PLK1,PPP2R5A,CENPH,BUB1B,ITGB1,INCENP,ACTG1,XPO1,RHOB,NUP85,CENPS,SRC,CKAP5,KNTC1,MAPRE1,RANGAP1,RANBP2,NSL1 R-HSA-1257604|PIP3 activates AKT signaling |0.00291817947030071 |-5.83679532621471|125 |71 |0.0156215621562156 |4545 |10287 |FGF20,FGF19,PIK3CB,AKT1S1,CDKN1A,PIK3R1,PPP2R1B,FGFR3,FGF2,FGF9,KIT,PRR5,FGFR2,GSK3A,FGF10,PPP2CA,PIP5K1A,CASP9,AGO2,FOXO3,PIP5K1B,INSR,EGF,FRS2,PTPN11,CD80,GSK3B,NRG1,RPS6KB2,TSC2,KL,TRIB3,NR4A1,PHLPP1,FGFR4,KLB,PHLPP2,RICTOR,PIP4K2A,TNRC6B,PIK3R2,ERBB2,FYN,MAPK1,SRC,FGFR1,PDGFRB,PIK3AP1,IRS1,MTOR,CREB1,PIK3R3,TNRC6A,AKT3,PPP2R5A,GRB2,PDPK1,NRG4,FGF3,MDM2,PDGFRA,TNRC6C,BTC,HBEGF,MAPKAP1,CD28,PDGFA,ERBB3,AGO3,FGF1,KITLG R-HSA-432722 |Golgi Associated Vesicle Biogenesis |0.00296405917854861 |-5.82119560597547|57 |36 |0.00792079207920792 |4545 |10287 |SNX2,DNM2,NAPA,TGOLN2,TXNDC5,CPD,AP1M1,SH3D19,PIK3C2A,CLINT1,PICALM,FTL,VAMP2,HIP1R,BLOC1S4,SORT1,AP1S2,ARF1,AP4E1,VAMP8,NECAP1,TPD52L1,SNX9,HSPA8,AP1S3,PUM1,DTNBP1,IGF2R,TBC1D8B,SNAPIN,OCRL,RAB5C,TFRC,ARRB1,SNX5,FTH1 R-HSA-425407 |SLC-mediated transmembrane transport |0.00319551960581573 |-5.74600557344738|287 |150 |0.033003300330033 |4545 |10287 |SLC25A18,SLC4A7,ALB,SLC4A5,SLC33A1,SLC16A7,SLC11A1,SLC44A1,SLC39A10,SLC7A7,G6PC2,SLC43A2,SLC7A1,SLC26A1,SLCO1B3,SLC2A9,RANBP2,SLC38A2,G6PC3,SLC45A3,SLC41A2,NUP188,NUP210,SLC25A10,SLC2A10,SLC6A1,SLC6A2,SLC2A2,SLC6A12,SLC22A8,SLCO2B1,CALM1,NUP93,SLC4A3,LCN1,SEH1L,HK2,SLC38A3,CP,SLC3A1,SLC1A3,SLC27A1,LOC100506403,SLC2A1,SLC17A5,BSG,SLC38A4,RUNX1,NUP205,SLC34A2,RHBG,SLC17A8,SLC15A2,RAE1,SLC5A11,SLC7A8,SLC7A5,SLC7A10,SLC31A1,SLC29A3,SLC38A5,SLC38A1,LCN12,SLC6A5,SLC47A1,SLC30A5,NUP58,SLC2A8,SLC20A1,SLC22A11,SLC22A3,SLC2A4,SLC6A14,SLC47A2,SLC35A2,NUP35,SLC15A1,SLC7A11,NUP214,CALM2,SLC4A10,NUP42,MIR6787,FGF21,SLC30A6,SLC5A9,SLC16A3,NUP85,SRI,SLC2A14,SLC43A1,GCKR,SLC5A10,SLC39A14,SLC40A1,SLC8A3,SLCO3A1,SLC9A8,SLC37A4,SLC1A7,SLC5A12,SLC1A5,SLC13A5,SLC3A2,MFSD4B,SLC7A9,SLC13A2,AHCYL2,SLCO4C1,SLC22A7,NUP43,SLC5A5,SLC7A2,SLC35D2,SLC24A4,SLC14A2,SLC27A4,SLC35C1,SLC36A2,SLC30A2,SLC12A7,SLC29A2,SLC20A2,SLC13A3,SLC6A6,SLC25A26,SLC7A6,SLC6A11,SLC35A1,SLC9A1,SLC2A11,CTNS,SLC44A5,SLC35B4,SLC26A3,SLC22A2,SLC13A1,SLC6A7,SLC35D1,SLC1A2,SLC1A4,SLC22A18,SLC11A2,SLC30A1,SLC28A3,SLC26A7,G6PC,SLC22A16,GCK,SLC2A5 R-HSA-6802952|Signaling by BRAF and RAF fusions |0.00326640033701832 |-5.72406671478162|61 |38 |0.00836083608360836 |4545 |10287 |JAK2,QKI,PAPSS1,IQGAP1,KSR1,KSR2,LMNA,FN1,FGA,BRAF,PEBP1,FGB,MAPK1,AKAP9,SRC,ITGB3,MPRIP,VWF,RAF1,TENT4A,MAP2K1,MACF1,KRAS,TRAK1,KIAA0754,AGTRAP,NRAS,AGGF1,YWHAB,BCL2L11,CSK,FGG,ATG7,ARRB1,VCL,ZC3HAV1,MARK3,TRIM24 R-HSA-168256 |Immune System |0.00329260737735348 |-5.71607551216686|2101 |984 |0.216501650165016 |4545 |10287 |FAF2,IL23R,TRIM37,PPP5C,NCF2,IFNAR1,ITGB1,CD34,MTOR,STAT5B,CAMK4,VAV3,SEC24D,CTSO,TNRC6B,C2,PECAM1,MUC3A,WSB1,PLA2G6,KLRK1,CAMK2G,RANBP2,ATF1,CSTB,MAPK1,BRWD1,RASGRP3,CCR1,PTK2B,ERBB2,ERBB3,PKM,RNF135,PDGFA,RASAL1,NCKAP1,VHL,DOCK1,ASB4,TAB1,ARRB1,NLRC4,GSTP1,CISH,SQSTM1,RACGAP1,ITPR1,KRAS,FBXW8,CALML5,TRIM26,PSMD7,NCK1,MMP2,TNFRSF1A,TUBB,RASA3,ARSA,CAB39,PSMB5,KLHL20,IL1R1,PRSS3,PTPN2,ASB14,TNFSF18,LRRFIP1,STAT5A,KLHL5,FGF19,KIF5B,RAE1,CAMK2B,APOB,ORAI1,FCGR3A,PEBP1,VEGFA,PTPRJ,PRKAR1A,ATP6V1C1,ATP6V0A1,FGF9,AP1M1,ADGRG3,FGA,CD53,GSK3B,LTA4H,TAPBP,UBE2K,PSMB11,IFITM1,DNAJC3,IRF9,RAB5C,VCL,PGM2,MANBA,CLCF1,TRAF2,SHC3,PRDX6,UBE2D4,BTN3A3,QSOX1,ATP6V0D1,NUP35,EGF,SIGLEC10,INSR,RNF144B,PAK3,IL7,GAB2,ADGRE3,MEFV,CDK13,GRIN2A,TMBIM1,ARPC2,ACLY,CSF1R,CXADR,PSMD12,KCMF1,NFATC3,UBOX5,IL9R,UBE2Q1,PYGB,KSR2,SEC23A,ELOC,ITGAL,UBE2N,DUSP16,MAPKAPK3,KLB,PSMB3,RASGRF1,UBE2W,CREBBP,CRK,IL1A,SOCS2,CASP4,PFKL,GPI,UBE2F,LAMP2,SKP1,TNFSF14,CDC42,CYSTM1,HSP90AB1,YWHAB,LTN1,XAF1,RIPK1,LBP,KPNB1,IRF1,SHC1,FGF1,SEC13,RPS6KA2,SLCO4C1,CTSD,AGO3,VAMP8,TRIM71,STAT6,C1S,ELANE,TOLLIP,PSMB10,KIF20A,KLHL21,UBAC1,POLR3H,ITCH,DHX58,HMOX1,IL6ST,TLR6,PTPN1,COMMD9,XRCC6,TAX1BP1,TAB2,RBCK1,CLU,GSK3A,ITGB3,RAB14,DUSP3,KIF3B,DTX4,CNPY3,DSN1,TMEM63A,PIK3R1,SEC61G,ATP6V1G2,ATP6V0D2,HLA-DMB,IQGAP1,REG3G,MCL1,FGF20,ADAR,CTSH,SERPINA1,TNFSF4,PSEN1,IL22RA2,SMURF2,IRF4,FBXW5,FBXO4,RASAL3,DSG1,IL7R,ARG1,EEA1,CANX,IL10RB,HIST1H3C,UBE2G2,TRIM25,UBE2D3,EIF4E2,RASGRP4,IFITM2,FBXO17,IFNGR1,PRKCA,OPRM1,PTPN4,SOCS1,SPTAN1,C4BPA,CYFIP1,HSPA5,CD81,PLAC8,RORA,DEFB1,IFNLR1,PTPN11,PSMA5,YWHAZ,JUN,CRCP,PSMA1,PLD1,NOD2,IL33,ACTG1,PAG1,RNF130,CAMK2A,DUSP1,KLHL41,STBD1,TRIM29,ARHGAP45,IL1RAP,NFASC,ATP6V0C,MAP2K7,MAP3K8,KCTD7,OTUD5,RAB37,NUP93,MVP,TEK,HLA-DPA1,NFKB1,UBE2V2,CUL1,LPCAT1,CFB,SCAMP1,MEF2A,CKAP4,SH3KBP1,APRT,TYK2,FASLG,BATF,DEFB112,MX2,IL1RL2,CD247,ARPC5,PLPP5,PSME4,MRC2,DEFB116,TNRC6C,TRIM69,ANPEP,ORM1,ATAD3B,FGF10,NUP205,CYFIP2,TLR5,ADCY9,GPR84,IL6R,CBLB,ARF1,AGO2,DEFB132,RNF41,TRPC1,RAB10,DDX41,AP2S1,UBA5,DIAPH1,ALDH3B1,YES1,HSP90AA1,FBXO27,KIT,IST1,PSAP,EIF4G3,IL19,DDX3X,CD36,HMGB1,VAT1,ABI2,ADCY3,MARK3,UBC,BCL2,POMC,RNF213,SERPINA3,TRIB3,TSC2,ILF2,C3,ANAPC7,NUP214,KIF2B,CFD,NIT2,ATP11A,RNF138,IL15,CDC20,FOS,NEDD4L,ATG5,FGFR1,CD160,OSMR,CCL3L3,HGSNAT,TRIM50,IRS1,STX4,UBE2H,PDGFRB,CARD11,PIP4K2A,DAB2IP,ACTR2,MYO9B,PPP3CA,FLNB,MIR5004,LTBR,BST2,AKAP9,DCTN4,RHOG,RAB7A,KPNA7,CRISPLD2,KPNA1,ATP11B,CGAS,IL12RB1,FGG,EPX,CCR6,PSMA3,INPP5D,NFKBIA,PROS1,KPNA2,SAR1B,ITGAM,CTNNB1,CCT2,MBL2,ISG15,SEC24A,FGF3,PSMD14,PNP,FBXO22,KCTD6,AHCYL1,RAB3D,NFKB2,MAPKAP1,ITGB2,RORC,RPS6KA1,SLC27A2,BPIFA2,OSM,ANAPC4,CHGA,PRKCE,PSMF1,RBBP6,SLPI,FRS3,RAP1GAP,NF1,SERPINB6,GSN,MALT1,DNAJC5,SIAH1,SPSB1,SP100,UNC13D,TRPM2,LY86,TANK,ACTR3,MAP3K3,IL1R2,CAPN1,FGF2,PIAS1,DDX58,RHOA,DUSP6,CSK,PSMA7,ECSIT,SURF4,CD68,CDC34,CEBPD,SEC61A1,AP2A1,SOCS3,PAK2,EIF4A1,RASA2,SKP2,IFI35,IQGAP2,DUSP5,CYBA,KLHL11,HSPA8,DUSP7,SERPINB1,CD80,ORM2,HEBP2,ABL1,MGST1,IMPDH1,BPI,HSPA6,DCTN1,RNF123,DEGS1,HVCN1,TMEM173,NFATC2,CREB1,SYNGR1,RAPGEF4,CTSZ,RNF182,RNASE8,TRIM46,FGB,SIAH2,ATP6V1G1,NUP210,PIK3R2,WASL,NUP188,BTRC,TSPAN14,CALM1,BCL6,CMTM6,IL34,IFIT3,DCTN2,BCL2L1,LGMN,IMPDH2,ARL8A,PSMB4,SEH1L,NCSTN,MAVS,NRG4,GRB2,STAT3,MAP2K1,PSMD3,JAK1,HBEGF,IL1B,FBXO32,CD96,DYNC1H1,ANXA1,PRKACA,CXCL2,COLEC11,TRIM56,UBE3C,PDXK,ASB2,GUSB,LYN,TBK1,MIF,HECTD1,UBE2G1,DYNC1I2,SAA1,STAT1,HIF1A,VAV2,HECTD2,UBE2J1,FGR,AP2A2,KLC4,ATP6V1D,NFKBIB,PLCG2,MUC13,ATP6AP2,HACE1,PPIA,PPP2R1B,IL31RA,IKBKG,ICAM4,CD14,C1R,RAB6A,EIF4E3,IFNL1,PRKCD,RASGRF2,CXCL8,PHLPP1,RAB31,ASB13,REL,FCGR2A,TMC6,NR4A1,SH2D1B,RANBP9,KL,FYB1,KLHL2,CALM2,CD27,CCL19,PIP5K1B,ITGAX,AP1S3,POLR3B,HEXB,COTL1,CASP8,SIGLEC1,IL22RA1,BIRC2,GHR,BPIFB2,CSF1,SUGT1,GOLGA7,DUSP10,CXCR1,NUP85,GYG1,FSCN1,PGM1,LONRF1,TRAF3,TNRC6A,ICAM2,IFNGR2,MAPK13,BRI3,AP2B1,CSNK2B,JAK2,ADCY1,AHSG,RAB5B,KPNA3,C5,C8B,ALAD,FN1,QPCT,JAML,ITGB5,MEX3C,HP,BCL10,KBTBD13,PSMB7,BRAP,ATG7,SPTBN1,IL20RB,MDM2,LAMP1,ZEB1,MX1,IDH1,S100P,GZMM,AKT3,LGALS3,IL3,MMP9,NRAS,TOM1,IL17RE,TNFRSF11A,FTL,EEF2,ALOX15,FBXW11,UBE2V1,BPIFB1,PLA2G2A,ITPR3,AP1S2,IFI30,NFAM1,PIP5K1A,EDA,SMARCA4,CDKN1A,ADCY8,JUP,GGH,PAK1,USP18,ITPR2,LGALS9,PSMC2,IRAK1,LCN2,TXNDC5,CCND1,FBXO6,ICAM3,BRAF,CEACAM8,ATP6V1C2,IL12A,EEF1A1,UBE2B,FBXO41,RPS6KB2,AGER,SMURF1,KIF4B,ANO6,GNLY,MYLIP,TXLNA,PLEKHO2,EIF4G2,AP2M1,EGR1,ASB7,FGFR4,GFRA3,CD180,RAPGEF1,MUC2,CTSC,PRLR,RNF14,HSPA1A,DGAT1,RNASE2,CD101,EIF4A3,UBE2E1,RHOF,PRCP,BTN3A2,JUNB,SLC2A5,HIST1H3J,CAPZA2,YPEL5,SPTB,SLC11A1,UBB,S100A11,GM2A,MYH9,BPIFB6,CD226,UBE2O,OLFM4,VWF,RNF217,PIK3AP1,POU2F1,GSDMD,PHLPP2,XDH,PELI1,ARSB,TRIM2,PSMB8,SPRED1,CTSE,NRTN,TRIM35,ATP6V0A4,UBE4A,RNASE7,BIRC3,CTSL,FYN,ATP6V1E2,ELMO1,LMO7,FBXL19,HSPA1B,MUC5B,NEDD4,ACTB,FBXO15,LIFR,KITLG,POLR3A,XRCC5,CAMK2D,PDPK1,PANX1,PPP2R5A,CAND1,NDN,BTC,POLR3E,NEFL,C8A,RNASEL,ISG20,PDGFRA,SNAP29,CD55,WWP1,ADAM8,ROCK1,EVL,RAF1,PPL,METTL7A,DSP,CASP10,CASP9,CAT,RAPGEF2,CPNE1,PYGL,S100A9,AKT1S1,ADAM17,TRIM62,IL9,LAMA5,IL23A,APEH,SYNGAP1,IL4R,PIK3C3,FGFR3,C5AR1,SIRPA,FBXL3,ALDOA,RNF19A,TRIM11,CD40,NUP58,NEU1,LRG1,MAP3K14,MIR6848,POLR2E,PGRMC1,TRIM8,MAPK14,VTN,WASF2,FBXW2,RASGRP2,MIR6843,SPRED2,UBE2C,DUSP9,MAP3K1,NUP42,MAPKAPK2,MIR4687,DYNC1LI1,EP300,EDAR,PIM1,SARM1,FRS2,ULBP1,MYO1C,C4BPB,APP,TXN,RHOU,LY96,CRKL,IL13,IRAK2,GLB1,PIK3R3,ANXA2,ADA2,ZBTB16,CSF3R,CIITA,OSTF1,VAMP3,RICTOR,MAOA,ENAH,VAPA,GFRA4,MAP2K3,RLIM,TYROBP,EIF4E,DNM2,ADCY4,PSMB1,POLR1D,SEM1,ARPC1B,BLNK,UBE2R2,STOM,PRDX4,ARIH2,SRC,SOS1,KCNAB2,TREM1,LAT2,STK10,PSMD1,PCBP2,GDNF,NOD1,CD28,CTSB,P2RX7,FBXO44,NUP43,MIR718,ACTR1B,POLR3GL,RASAL2,DSC1,TAB3,CUL2,RIPK2,ADCY7,CARD9,ABI1,CCL20,IL32,BTN3A1,FBXO21,KEAP1,ASB3,KLC2,IL1RN,NCR3LG1,PSMC4,ACAA1,GBP6,FGFR2,PRR5,IP6K2,PSMB9,UBR2,RNF114,TNFSF8,PSMA6,PPP2CA,F13A1,CD274,WASF1,KSR1,ASB1,MAP2K6,PPM1B,PIK3CB,SVIP,CREG1,UNKL,TLR9,ZNRF1,UBA52,TRIM14,IFNL2,UBE2J2,SIGLEC11,TRIM31,KBTBD7,EDARADD,RAB27A,PTK2,RNF7,RPS6KA3,SEC22B,IRF8,PTPRA,NRG1,FBXO31,IGF2R,AGPAT2,ICAM1,CDH1,CST3,NOS1,CTLA4,KIF3C,FBXO7,ARPC1A,UBE2D1,FTH1,FZR1,RAP2B,PRKDC,FOXO3,ATP6V0E1,HLA-DOB,CHIT1,CAMP,SAMHD1,TRAF7,STX1A,IL27,IRF2 R-HSA-5653656|Vesicle-mediated transport |0.00334436676664337 |-5.70047791075384|650 |321 |0.0706270627062706 |4545 |10287 |SNX9,PACSIN1,DYNC1LI1,AMBP,TBC1D14,MYO1C,MAP1LC3B,KIFC1,KIF2B,CUX1,VPS4B,FOLR1,RABGEF1,SLC2A4,TFRC,UBC,TSC2,HYOU1,ANK1,YWHAG,CD36,SLC2A8,GJD4,HSP90AA1,GOSR1,KIF1B,VPS4A,EPS15L1,DENND1B,ARF1,RAB10,AP2S1,RAB39B,CD55,NBAS,TBC1D20,ARPC5,APOA1,LMAN1,PPP6R3,LDLR,SNAP29,SH3KBP1,COG2,SNAPIN,GJA10,EXOC6,FNBP1L,PACSIN2,SEC16A,AGPAT3,DTNBP1,TGFA,GJA1,SCARB1,MAN2A1,ASPSCR1,AREG,MYH1,GJB1,RAB11A,STAM,DENND3,ANKRD27,CLVS1,USP6NL,SPTB,TBC1D7,UBB,HPR,RAB4A,C2CD5,ALB,BICD1,HSPA8,MYH13,CHMP4A,TRAPPC10,CHMP3,KIF3C,MAN1A2,MON1A,PRKAG2,SPARC,HIP1,ARPC1A,FTH1,SEC22B,FNBP1,GABARAPL2,RAB32,IGF2R,SURF4,KIF9,AP2A1,HPX,ACTR3,UBA52,ST5,KIF26B,CPD,RAB27A,RAB21,RAB30,SH3D19,GOLGA5,SNX2,KIF13B,NAPA,CYTH1,GCC2,SYNJ2,AP4E1,TBC1D16,DENND4A,PPP6R1,DENND5A,SYTL1,LDLRAP1,HPS1,SCARB2,ARF6,MON1B,LRP2,TACR1,PUM1,KLC2,RALGAPA2,RAB3IP,CHMP2B,DAB2,SAR1B,CHMP4C,STX6,AP4S1,ANK3,TRAPPC8,SEC24A,SNX5,STX16,EXOC8,GOSR2,DCTN4,SRC,RAB7A,SCFD1,VPS37B,VAMP3,F5,ACTR2,DNM2,CHMP6,CYTH3,GOLGA4,VPS54,STX4,TRAPPC12,APP,RAB36,RAB43,TRAPPC6B,MSR1,CLINT1,PICALM,VAMP2,COPS5,COPG2,ARPC2,AP1S3,GALNT2,EGF,BIN1,CALM2,COG1,EXOC7,TBC1D25,COPG1,RAB5C,RAB31,TRAPPC5,PRKAG1,TMED10,RABGAP1,RIC1,HPS4,RAB6A,TBC1D8B,APOB,SBF1,AP1M1,AP2A2,KLC4,MIA2,COG3,KIF5B,KIF27,KDELR3,RAB3GAP1,CHMP2A,DYNC1I2,GAPVD1,SAA1,NAPB,COLEC11,RAB8B,TRIP10,DENND4C,GJD3,ITSN1,SEC23IP,DYNC1H1,RAB35,SYT11,KIF21A,RACGAP1,GRB2,ALS2,KIF16B,SH3GL1,WNT5A,BNIP1,OCRL,KIF18B,COPS8,ARFGAP3,ARFGAP1,COPB2,TBC1D13,ARRB1,CALM1,TBC1D1,CHMP4B,DCTN2,USO1,VPS45,LMAN2L,WASL,TF,PLA2G6,AGTR1,PPP6C,RALGAPB,SEC24D,ARFGAP2,CTSZ,DENND1A,COPS7B,DCTN1,HIP1R,BLOC1S4,TPD52L1,NECAP1,SBF2,TRAPPC6A,PACSIN3,YWHAZ,SPTAN1,MAN1A1,MYH4,RHOQ,CTSC,STAB1,SCARA5,RAB27B,KIF4B,RAB33B,KIAA0319,NAPG,AP2M1,TXNDC5,SERPINA1,NAA30,CNIH1,TBC1D24,PIK3C2A,CTTN,RALA,HSPH1,TGOLN2,RAB14,RIN2,AP1S2,PRKAB2,SCOC,KIF3B,MIR6886,MCFD2,FTL,MAN1C1,KIF20A,VAMP8,ANK2,CLVS2,SYS1,COPS7A,AKT3,EPS15,HP,SEC13,SPTBN1,RAB12,YWHAB,DENND2A,GJA5,TBC1D4,RAB5B,LRP1,STAB2,RAB1A,SEC23A,ITSN2,AP2B1,PRKAB1,STON2,ALPP,FZD4,COG7,GRK3,YWHAQ,RIN3,SORT1 R-HSA-1483257|Phospholipid metabolism |0.00365166438615881 |-5.61257221911452|207 |111 |0.0244224422442244 |4545 |10287 |PLA2G1B,PIK3R5,MBOAT1,MGLL,MTMR7,PNPLA3,VAC14,PIP5K1B,AGPAT1,LCLAT1,DGAT1,PCTP,SELENOI,PEMT,TNFAIP8L3,PIK3C2G,CPNE6,CSNK2A1,MIR6848,DMGDH,SARDH,CHKA,LPIN3,PLAAT2,AGPAT2,PIK3C2A,SLC44A5,PIK3CG,PNPLA8,PIK3C2B,PIK3C3,ETNK1,INPP4A,AGPAT4,PLEKHA6,OSBPL8,PI4KB,PNPLA7,CEPT1,PIK3CB,PI4K2A,HADHA,PIK3R1,CHDH,CPNE1,PIP5K1A,GDPD1,MIR7109,SYNJ2,ARF1,GPAT2,RAB14,PLA2G2A,ETNPPL,GPAM,PLAAT5,PITPNM2,LPIN1,GPAT4,PITPNB,PCYT1B,LPIN2,TNFAIP8,GNPAT,TNFAIP8L1,PNPLA2,ACHE,CDIPT,LPCAT1,PCYT1A,OCRL,ETNK2,MTM1,MFSD2A,PLEKHA2,HADHB,PLA2G4E,RUFY1,GPD1L,INPP5D,GDPD5,PI4KA,AGPAT3,CDS2,PIK3R2,MTMR3,PGS1,MTMR2,CSNK2B,PLA2G6,MTMR14,GPAT3,CHPT1,PIP4K2A,PISD,PIKFYVE,ENPP6,CSNK2A2,PIP4P1,PLA2G4C,PLB1,ALDH7A1,CRLS1,PIK3R3,GPD1,ABHD3,RAB4A,PLD1,SLC44A1,MTMR4,GPCPD1 R-HSA-199991 |Membrane Trafficking |0.00365630398993771 |-5.61130248061444|610 |302 |0.0664466446644665 |4545 |10287 |ITSN1,GJD3,DENND4C,TRIP10,RAB8B,NAPB,DYNC1I2,GAPVD1,KDELR3,CHMP2A,RAB3GAP1,KIF27,KIF5B,COG3,MIA2,KLC4,AP2A2,AP1M1,SBF1,APOB,TBC1D8B,RAB6A,HPS4,RABGAP1,RIC1,TMED10,PRKAG1,TRAPPC5,RAB31,RAB5C,COPG1,EXOC7,TBC1D25,COG1,CALM2,BIN1,EGF,GALNT2,AP1S3,ARPC2,COPG2,BLOC1S4,DCTN1,HIP1R,COPS7B,DENND1A,CTSZ,ARFGAP2,SEC24D,RALGAPB,PPP6C,AGTR1,PLA2G6,TF,WASL,LMAN2L,VPS45,DCTN2,USO1,CHMP4B,TBC1D1,CALM1,ARRB1,TBC1D13,COPB2,ARFGAP3,ARFGAP1,COPS8,KIF18B,OCRL,BNIP1,WNT5A,SH3GL1,KIF16B,ALS2,GRB2,RACGAP1,KIF21A,SYT11,DYNC1H1,RAB35,SEC23IP,MAN1C1,FTL,MCFD2,MIR6886,SCOC,KIF3B,PRKAB2,AP1S2,RAB14,RIN2,TGOLN2,RALA,CTTN,PIK3C2A,CNIH1,TBC1D24,NAA30,SERPINA1,TXNDC5,AP2M1,NAPG,KIAA0319,RAB33B,KIF4B,RAB27B,CTSC,RHOQ,MYH4,MAN1A1,SPTAN1,YWHAZ,PACSIN3,TRAPPC6A,SBF2,TPD52L1,NECAP1,SORT1,RIN3,YWHAQ,GRK3,COG7,FZD4,STON2,ALPP,PRKAB1,AP2B1,SEC23A,ITSN2,RAB1A,RAB5B,TBC1D4,GJA5,DENND2A,YWHAB,RAB12,SPTBN1,SEC13,EPS15,AKT3,SYS1,COPS7A,ANK2,CLVS2,VAMP8,KIF20A,TBC1D20,CD55,NBAS,RAB39B,AP2S1,RAB10,ARF1,DENND1B,EPS15L1,VPS4A,KIF1B,GOSR1,GJD4,SLC2A8,YWHAG,ANK1,TSC2,UBC,TFRC,RABGEF1,SLC2A4,FOLR1,VPS4B,CUX1,KIF2B,KIFC1,MAP1LC3B,MYO1C,TBC1D14,DYNC1LI1,PACSIN1,SNX9,RAB4A,C2CD5,TBC1D7,UBB,SPTB,USP6NL,CLVS1,ANKRD27,DENND3,STAM,RAB11A,GJB1,MYH1,ASPSCR1,AREG,MAN2A1,GJA1,TGFA,DTNBP1,AGPAT3,SEC16A,PACSIN2,FNBP1L,EXOC6,SNAPIN,GJA10,COG2,SH3KBP1,PPP6R3,SNAP29,LDLR,LMAN1,ARPC5,SCARB2,HPS1,LDLRAP1,SYTL1,PPP6R1,DENND5A,DENND4A,AP4E1,TBC1D16,SYNJ2,GCC2,CYTH1,NAPA,KIF13B,SNX2,GOLGA5,RAB30,SH3D19,RAB21,CPD,RAB27A,KIF26B,ST5,ACTR3,UBA52,AP2A1,KIF9,IGF2R,SURF4,RAB32,GABARAPL2,SEC22B,FNBP1,FTH1,ARPC1A,HIP1,PRKAG2,KIF3C,MON1A,MAN1A2,CHMP3,TRAPPC10,CHMP4A,MYH13,HSPA8,BICD1,COPS5,VAMP2,PICALM,TRAPPC6B,CLINT1,RAB36,RAB43,APP,TRAPPC12,STX4,VPS54,GOLGA4,CYTH3,DNM2,CHMP6,ACTR2,F5,VAMP3,VPS37B,SCFD1,RAB7A,SRC,DCTN4,GOSR2,STX16,EXOC8,TRAPPC8,SNX5,SEC24A,ANK3,AP4S1,STX6,CHMP4C,SAR1B,DAB2,CHMP2B,RAB3IP,RALGAPA2,KLC2,TACR1,PUM1,MON1B,ARF6,LRP2 R-HSA-5627123|RHO GTPases activate PAKs |0.00374491095459057 |-5.58735743944101|23 |17 |0.00374037403740374 |4545 |10287 |PAK2,CTTN,CALM2,PPP1CB,PAK3,PAK1,MYLK,MYL9,MYH10,CALM1,CDC42,MYL12B,PPP1R12B,MYH11,MYH9,MYL6,MYH14 R-HSA-8855121|VLDL interactions |0.00374491095459057 |-5.58735743944101|23 |17 |0.00374037403740374 |4545 |10287 |APOC1,VLDLR,NR1H3,PCSK9,AP2S1,NR1H2,MYLIP,P4HB,AP2A1,AP2M1,APOB,RELN,DAB1,FYN,AP2B1,AP2A2,SH3KBP1 R-HSA-198203 |PI3K/AKT activation |0.00382929434520975 |-5.56507473683517|128 |72 |0.0158415841584158 |4545 |10287 |FGFR1,PIK3AP1,PDGFRB,TNRC6A,PIK3R3,IRS1,MTOR,CREB1,TNRC6B,PIP4K2A,PHLPP2,RICTOR,KLB,FYN,ERBB2,PIK3R2,SRC,MAPK1,PDGFA,CD28,ERBB3,AGO3,FGF1,KITLG,AKT3,PPP2R5A,NRG4,FGF3,PDPK1,MDM2,GRB2,PDGFRA,TNRC6C,MAPKAP1,BTC,HBEGF,PRR5,GSK3A,FGFR2,FGF10,CASP9,PPP2CA,PIP5K1A,AGO2,FGF19,FGF20,CDKN1A,PIK3R1,PIK3CB,AKT1S1,FGF2,FGFR3,PPP2R1B,FGF9,KIT,RHOA,NRG1,RPS6KB2,GSK3B,NR4A1,KL,TSC2,TRIB3,PHLPP1,FGFR4,FOXO3,PIP5K1B,EGF,INSR,PTPN11,FRS2,CD80 R-HSA-168638 |NOD1/2 Signaling Pathway |0.00433995010891807 |-5.4398924265769 |32 |22 |0.00484048404840484 |4545 |10287 |MAPK14,MAP2K6,UBE2N,MAPK13,TAB3,RIPK2,CARD9,IRAK1,CASP4,ITCH,CASP8,BIRC3,BIRC2,IKBKG,TAB2,NOD2,IRAK2,UBE2V1,NOD1,MIR718,CASP9,TAB1 R-HSA-3371556|Cellular response to heat stress |0.00464755730097808 |-5.37141350902498|89 |52 |0.0114411441144114 |4545 |10287 |NUP58,HSPA12B,HSPA9,NUP93,GSK3B,HSP90AB1,HSPA1B,HSPA13,DNAJB6,SEH1L,RPS19BP1,HSPA4L,NUP43,NUP214,HSPA1A,NUP35,CAMK2D,ATR,HSPA12A,RPTOR,SIRT1,EP300,RPA1,MAPKAPK2,HSPA8,NUP42,HSPA5,RPA3,HSPA6,NUP205,NUP85,CAMK2A,BAG4,MTOR,CREBBP,RANBP2,CAMK2G,CAMK2B,HSPA7,RPA2,RAE1,DNAJC2,HSPH1,AKT1S1,BAG3,ATM,EEF1A1,NUP210,NUP188,MAPK1,DNAJB1,HSP90AA1 R-HSA-2682334|EPH-Ephrin signaling |0.00479398639029859 |-5.34039298187706|95 |55 |0.0121012101210121 |4545 |10287 |PAK2,NCK2,PAK3,ARPC2,ARPC5,EPHA2,MMP9,MMP2,MYH10,CDC42,RHOA,SDC2,ARHGEF7,ACTB,NGEF,MYH11,EFNA5,AP2A1,AP2M1,MYH14,ARPC1A,NCSTN,LIMK2,AP2A2,ARHGEF28,ROCK2,ACTR2,AP2B1,PAK1,ARPC1B,ACTR3,YES1,HSP90AA1,SRC,VEGFA,MYL9,SHB,PTK2,FYN,WASL,MYL12B,EFNB1,LYN,ACTG1,MYL6,ITSN1,ROCK1,MYH9,KALRN,EPHA5,EPHB4,VAV2,AP2S1,VAV3,EFNA1 R-HSA-3928663|EPHA-mediated growth cone collapse |0.00487106520345347 |-5.32444263819652|34 |23 |0.00506050605060506 |4545 |10287 |EFNA1,MYH14,EPHA5,MYH9,MYL6,ROCK1,EFNA5,LYN,NGEF,MYH11,MYL12B,RHOA,PTK2,FYN,MYH10,SHB,EPHA2,MYL9,VEGFA,SRC,HSP90AA1,YES1,ROCK2 R-HSA-3000170|Syndecan interactions |0.00517427657785707 |-5.26405574132092|20 |15 |0.0033003300330033 |4545 |10287 |ITGA6,ITGB5,ACTN1,ITGB3,VTN,SDC2,SDC3,THBS1,CASK,PRKCA,SDC1,SDC4,FGF2,ITGA2,ITGB1 R-HSA-430039 |mRNA decay by 5' to 3' exoribonuclease |0.00524511002677201 |-5.25045905989499|15 |12 |0.00264026402640264 |4545 |10287 |DDX6,LSM3,DCP1B,PATL1,XRN1,DCP1A,EDC4,EDC3,LSM2,LSM1,DCP2,LSM4 R-HSA-69298 |Association of licensing factors with the pre-replicative complex |0.00524511002677201 |-5.25045905989499|15 |12 |0.00264026402640264 |4545 |10287 |ORC4,E2F3,GMNN,CDC6,UBB,UBC,ORC1,UBA52,CDT1,E2F2,ORC5,ORC2 R-HSA-373755 |Semaphorin interactions |0.00533913565199448 |-5.23269150203363|68 |41 |0.00902090209020902 |4545 |10287 |CDC42,FARP2,RHOA,SEMA7A,RND1,GSK3B,HSP90AB1,MYH11,MYH14,PLXNA2,ARHGEF12,SEMA6A,LIMK2,DPYSL2,PLXNB1,PAK2,PAK3,SEMA6D,DPYSL4,MYH10,PLXND1,RHOB,MYL12B,NRP1,ROCK1,MYL6,MYH9,PLXNC1,ITGB1,ROCK2,TYROBP,SEMA4D,PAK1,CDK5R1,HSP90AA1,MYL9,ITGA1,RHOG,FYN,ARHGAP35,ERBB2 R-HSA-114508 |Effects of PIP2 hydrolysis |0.00535638543149409 |-5.22946589117815|27 |19 |0.00418041804180418 |4545 |10287 |ITPR3,DGKD,PRKCE,PRKCD,DGKI,ABHD12,MGLL,DGKA,DAGLB,DGKQ,PRKCH,DGKZ,DGKK,ITPR1,ABHD6,RASGRP2,DGKE,ITPR2,TRPC3 R-HSA-5633007|Regulation of TP53 Activity |0.00569893520313969 |-5.16747592805886|162 |88 |0.0193619361936194 |4545 |10287 |RAD9B,RHNO1,RFC2,HIPK1,HIPK2,PRR5,RPA3,PRDM1,TAF4,RBBP8,PPP1R13B,PPP2CA,CCNA2,HDAC2,CHEK2,POU4F2,PRKAB2,CDK5R1,RFC3,RPA2,MAP2K6,USP2,TAF6,SGK1,PPP2R1B,UBA52,TP73,USP7,TOP3A,RFFL,TPX2,PRKAG2,DNA2,PRKAG1,PLK3,UBC,CSNK2A1,SMYD2,GATAD2A,MAPK14,AURKB,KMT5A,PHF20,ATR,ATRIP,BRD1,EP300,BRD7,BANP,RMI2,UBB,MDM4,PIP4P1,CSNK2A2,TAF3,ING5,CHEK1,MTOR,NUAK1,PRKAA1,EXO1,BARD1,CSNK2B,BRCA1,PRKAB1,SETD9,RICTOR,PIP4K2A,ATM,MTA2,JMY,TOPBP1,KAT6A,EHMT1,TAF1,MEAF6,AKT3,TAF11,TBP,GATAD2B,MDM2,PDPK1,MIR1257,TAF12,NBN,RBBP7,RPA1,MAPKAP1 R-HSA-1227986|Signaling by ERBB2 |0.00574174144920041 |-5.15999272630116|51 |32 |0.00704070407040704 |4545 |10287 |SRC,UBA52,HSP90AA1,YES1,SOS1,FYN,PTPN18,ERBB2,PIK3R1,DIAPH1,MEMO1,RNF41,ERBIN,UBB,PRKCE,GRB7,HBEGF,BTC,NRAS,EGF,NRG4,GRB2,KRAS,AKT3,UBC,SHC1,PRKCA,PTPN12,NRG1,RHOA,ERBB3,PRKCD R-HSA-6806667|Metabolism of fat-soluble vitamins |0.0060099983776178 |-5.11433080038218|53 |33 |0.00726072607260726 |4545 |10287 |GPC1,LRP2,LDLR,AKR1C1,SDC4,APOA1,GPC5,APOC3,CYP27B1,GPC3,APOA2,HSPG2,RBP4,VKORC1L1,LGMN,APOM,SDC1,APOC2,LRP8,GPC4,RDH11,SDC3,SDC2,APOA4,APOB,CYP2R1,LRP1,GC,PLB1,CYP24A1,MIR6886,GPC6,AKR1C3 R-HSA-211859 |Biological oxidations |0.0060777863458121 |-5.10311473715999|222 |117 |0.0257425742574257 |4545 |10287 |GSTO1,MAT2B,SULT1C2,AHR,GGCT,MTR,ACSS2,CYP26C1,GLYATL1,NCOA2,ACSM2B,CYP27A1,ALDH1B1,CYP3A43,CYP27B1,PTGIS,UGT2B10,MAT2A,GGT1,MIR4761,POMC,NCOA1,CYP2C9,POR,UGDH,SULT2A1,ACSM1,SLC35D1,CNDP2,FDX1,EPHX1,GSS,UGT2A3,ADH7,CYP4F12,UGT2B7,NQO2,CYP3A7-CYP3A51P,ACSS1,GSTO2,SULT2B1,MTRR,MARC2,CYP24A1,AKR1A1,ALDH2,CYP2J2,GLYATL3,CYP2W1,SULT1B1,GCLM,CYP19A1,CYP2S1,MAT1A,MAOB,BPHL,CYP8B1,ADH5,ABHD14B,ADH6,CYP51A1,MIR4651,ARNT,CHAC2,COMT,GCLC,TBXAS1,CHAC1,MGST3,GSTP1,AHCY,MGST2,PAPSS2,UGT2B4,MARC1,UGP2,ABHD10,HPGDS,CYB5B,HSP90AB1,GSTA1,CYP3A4,ALDH1A1,CYP2C8,CYP2R1,UGT2B15,CYP2A6,SULT1A1,SMOX,ADH4,N6AMT1,CYP11B2,GSTA3,CYP2B6,FDXR,SULT1A2,PAPSS1,GGT5,CES1,MAOA,SULT1E1,UGT1A5,CYP4F3,DPEP1,RXRA,CYP26A1,CYP2C18,CYP1A1,OPLAH,SLC26A1,CYP26B1,UGT1A4,MGST1,NR1H4,ACSM2A,AOC3,ESD R-HSA-1640170|Cell Cycle |0.00610952169361943 |-5.09790679141288|621 |305 |0.0671067106710671 |4545 |10287 |HIST1H3J,PSMA5,YWHAZ,CENPF,MAD1L1,HIST1H4K,UBE2E1,KMT5A,MCM4,TAOK1,PRKCA,CENPT,UIMC1,LPIN3,HIST1H3C,TPX2,BUB3,CDK4,CCND1,LMNB1,MSH5,PSMC2,SYNE2,MDC1,COP1,CDKN1A,VRK1,CHEK2,DSN1,DYRK1A,CSNK1E,RFC1,CLASP2,CENPW,CLIP1,FBXW11,RAD9B,RAB2A,ITGB3BP,PRDM9,PSMB10,KIF20A,RUVBL2,RBBP7,PDS5A,AKT3,MDM2,PRIM2,CEP70,ABRAXAS1,ACD,PSMB7,WEE1,NDEL1,CDK5RAP2,HIST1H2BJ,SEC13,CCNE1,SPC24,PPP2R3B,HSP90AB1,YWHAB,PPP2R2D,SKP1,CSNK2B,MIS18BP1,CDK6,RAB1A,GMNN,UBE2N,PSMB3,POLE3,MDM4,XPO1,YWHAQ,MIR4738,PSMD12,ORC4,CNTRL,NUP85,CNEP1R1,WRAP53,MCM10,AURKB,NUP35,OIP5,CENPC,HIST1H4H,LIN37,MLH1,RBL2,HIST1H2BH,PSMB11,ENSA,PPP2R1B,PPP2R2A,POLE4,RAE1,RFC3,PLK4,SET,TERF2,LMNA,CDC25B,ORC2,NUDC,DYNC1I2,MIS18A,CEP72,MCPH1,PSMB5,RHNO1,PCNA,CDKN2B,PCNT,LPIN1,DYNC1H1,NINL,NEK2,TUBB,PRKACA,HMMR,PSMD3,PSMD7,NBN,CEP76,RPA1,CEP78,CENPH,HIST1H2BL,GORASP2,NCAPD2,SEH1L,PSMB4,NCAPH2,USO1,DCTN2,RAD21,SGO2,NUP188,RBL1,NUP210,BTRC,CKAP5,H2AFV,MAPK1,RANGAP1,RANBP2,ATM,CSNK2A2,CHEK1,PPP1R12B,TK2,DCTN1,CCND3,INCENP,MASTL,ATRIP,ATR,E2F2,NUMA1,H2AFJ,HAUS6,FZR1,SKP2,UBE2D1,HJURP,LIN52,TUBGCP5,RPS27,TOP3A,SKA1,PSMA7,HAUS4,TP53BP1,UBA52,HIST1H2BC,NEK6,RPA2,PPP1CB,PHLDA1,BUB1,CEP57,CCNA2,PSMA6,PPP2CA,PSMB9,PSMF1,RFC2,CETN2,E2F3,PHF8,ANAPC4,PSMC4,CENPA,DIDO1,HDAC8,MCM3,SUN1,PLK1,BORA,UBE2I,PSMD14,TINF2,NUP43,REC8,HIST1H4B,PSMA3,HIST1H2AE,DKC1,PPP1CC,CEP250,MIR484,PSMD1,CDT1,AKAP9,H2AFZ,ORC1,HIST1H4D,PSMB1,KNTC1,EXO1,SEM1,BARD1,BRCA1,ESCO1,RMI2,CCNH,CDC20,NUP42,E2F5,NDE1,EP300,NEDD1,KIF2B,UBE2C,AHCTF1,MSH4,ANAPC7,SYNE1,NUP214,DNA2,CENPL,ORC6,CDC7,CENPU,PCM1,CSNK2A1,CEP164,PSMC3IP,UBC,YWHAG,KNL1,NUP58,HIST1H4I,ANAPC15,HIST1H2BO,MYBL2,HSP90AA1,POT1,TFDP2,ODF2,RNF8,GINS1,CEP152,CLASP1,NUP205,RPA3,RBBP8,PSME4,LPIN2,RCC2,RUVBL1,FKBP6,MCM5,PPP2R5A,SUN2,UBE2V2,CUL1,CEP192,SMARCA5,NUP93,POLD2,NHP2,CENPS,ORC5,CDKN2D,DHFR,TOPBP1,MAPRE1,CDC6,HAUS3,NSD2,STAG1,ESPL1,PSMB8,NSL1,BUB1B,HIST1H4E,UBB,LIN54,CENPX,CCP110,PSMA1,CEP63 R-HSA-5621481|C-type lectin receptors (CLRs) |0.00612357081570702 |-5.09560988598957|144 |79 |0.0173817381738174 |4545 |10287 |UBC,MUC2,MAP3K14,UBE2D1,PSMA7,IKBKG,PRKCD,PSMB11,CDC34,EP300,CASP8,PSMA5,PAK3,CALM2,PAK2,MALT1,ITPR3,PSMB9,PSMF1,RAF1,PSMA6,PSMC4,UBE2V1,PSMB5,FBXW11,LYN,TAB2,UBA52,ICAM3,PLCG2,PSMC2,MUC13,ITPR2,PAK1,BCL10,CUL1,PSMB4,TAB1,PSMB7,PSMD1,MUC5B,CALM1,NFKBIA,NFKB1,PSMA3,IL1B,PSMD7,PSMD3,NFKB2,PSMB10,AHCYL1,PRKACA,NRAS,PSME4,ITPR1,TAB3,PSMD14,PDPK1,CARD9,KRAS,ICAM2,NFATC2,NFATC3,PSMD12,PSMA1,UBB,SRC,BTRC,SKP1,FYN,PSMB3,MUC3A,UBE2N,PSMB8,CARD11,CREBBP,PPP3CA,SEM1,PSMB1 R-HSA-445989 |TAK1 activates NFkB by phosphorylation and activation of IKKs complex |0.00614172030027488 |-5.09265039686808|29 |20 |0.0044004400440044 |4545 |10287 |NFKBIB,IRAK1,RIPK2,UBE2N,TAB3,NFKB2,UBE2V1,NOD1,IRAK2,NFKBIA,NOD2,TAB2,HMGB1,NFKB1,AGER,APP,IKBKG,TAB1,SAA1,MIR718 R-HSA-5218920|VEGFR2 mediated vascular permeability |0.00614172030027488 |-5.09265039686808|29 |20 |0.0044004400440044 |4545 |10287 |VAV3,VAV2,CTNNB1,TRIB3,CDH5,MTOR,PRR5,CALM1,CTNNA1,HSP90AA1,MAPKAP1,PAK1,AKT3,PDPK1,PAK2,CAV1,RICTOR,PAK3,JUP,CALM2 R-HSA-416482 |G alpha (12/13) signalling events |0.00628467951991275 |-5.06964042950291|88 |51 |0.0112211221122112 |4545 |10287 |AKAP13,PIK3R3,ARHGEF2,ARHGEF1,GNG7,MIR7706,VAV3,VAV2,ADRA1A,PLEKHG2,RHOB,ITSN1,KALRN,ROCK1,ABR,SOS1,FGD2,ARHGEF10L,GNGT2,RHOG,ARHGEF4,ARHGEF26,PIK3R2,FGD4,PIK3R1,ROCK2,GNA12,ARHGEF12,RASGRF2,ARHGEF19,TBXA2R,ARHGEF6,ARHGEF3,TIAM2,CDC42,ARHGEF7,RHOA,TRIO,GNB5,ARHGEF16,NET1,NGEF,OBSCN,ADRA1D,GNG4,GNB4,ARHGEF10,PREX1,PLXNB1,MCF2L,GNG10 R-HSA-381119 |Unfolded Protein Response (UPR) |0.00638339585277426 |-5.05405505790326|92 |53 |0.0116611661166117 |4545 |10287 |GSK3A,DCTN1,CTDSP2,WIPI1,PDIA5,SEC62,WFS1,GET3,DCP2,EXOSC3,EDEM1,MBTPS2,KDELR3,HDGF,SEC61G,LMNA,ACADVL,SYVN1,SRPRB,ERN1,XBP1,TATDN2,GOSR2,IGFBP1,SEC61A1,ATF3,EXOSC9,CXXC1,HYOU1,ADD1,PARN,SHC1,ATF4,ARFGAP1,EXTL3,MBTPS1,DNAJC3,EIF2AK3,CXCL8,DIS3,DDIT3,ZBTB17,DNAJB11,GFPT1,HERPUD1,ATP6V0D1,NFYA,ASNS,TSPYL2,ATF6,NFYC,HSPA5,SEC63 R-HSA-1250196|SHC1 events in ERBB2 signaling |0.00638597173509807 |-5.0536516107723 |22 |16 |0.00352035203520352 |4545 |10287 |PRKCD,PRKCE,ERBB3,NRG1,PRKCA,PTPN12,SHC1,KRAS,NRG4,EGF,GRB2,NRAS,ERBB2,HBEGF,BTC,SOS1 R-HSA-196849 |Metabolism of water-soluble vitamins and cofactors |0.00648622548491285 |-5.03807450683653|122 |68 |0.014961496149615 |4545 |10287 |MTHFD2L,NADK,PPCDC,MTHFD2,CTRC,ENPP2,CD38,MTR,FPGS,GSTO1,NMNAT1,PCCB,CYB5A,PTGIS,ABCC1,MTHFD1L,SLC25A32,AASDHPPT,PRSS3,PARP14,LMBRD1,PARP8,PDXK,SLC46A1,MMACHC,TPK1,MTHFR,MTRR,GSTO2,ENPP1,SLC23A2,AMN,ACACA,PANK1,THTPA,FLAD1,SHMT2,SLC19A3,MOCS1,MOCOS,MMADHC,ALDH1L1,CYP8B1,NFS1,SLC2A1,PANK2,ENPP3,AOX1,GPHN,MMAA,COASY,ACACB,PANK3,SLC19A1,NMNAT2,NAXD,MMAB,FASN,SLC25A19,BTD,DHFR,SLC23A1,PNPO,NT5E,RFK,MOCS3,SLC19A2,HLCS R-HSA-5620912|Anchoring of the basal body to the plasma membrane |0.00650967486193833 |-5.03446576841164|100 |57 |0.0125412541254125 |4545 |10287 |MKS1,CEP89,TMEM216,CDK5RAP2,PCM1,RPGRIP1L,CEP164,DCTN2,CEP192,YWHAG,NPHP1,CEP97,MIR484,CEP250,CEP162,TTBK2,DYNC1H1,NINL,NEK2,TUBB,PRKACA,CC2D2A,TCTN1,CEP83,NDE1,CEP76,PLK1,RAB3IP,CEP78,HAUS6,MARK4,NEDD1,CEP70,CEP57,DYNC1I2,IQCB1,RAB11A,CEP152,CSNK1E,CLASP1,SCLT1,CEP72,DCTN1,CCP110,PCNT,CETN2,CNTRL,CEP63,HAUS4,AKAP9,HSP90AA1,CKAP5,MAPRE1,PLK4,HAUS3,SEPTIN2,ODF2 R-HSA-5357801|Programmed Cell Death |0.00665256684546508 |-5.01275250699079|175 |94 |0.0206820682068207 |4545 |10287 |PSMC4,ROCK1,TJP2,PSMB5,GSN,DSP,PSMB9,PSMF1,DNM1L,PPP1R13B,PSMA6,CASP9,BCAP31,LMNA,UNC5A,PSMC2,DIABLO,LMNB1,TFDP2,UBA52,TP73,DAPK1,DSG2,FAS,H1F0,PTK2,DSG1,PSMA7,TNFSF10,CD14,BCL2L11,DAPK2,PSMB11,PRKCD,HMGB1,STK24,YWHAG,UBC,BCL2,CDH1,ADD1,TRAF2,BBC3,MIR3191,PAK2,SPTAN1,HIST1H1C,MLKL,PLEC,CASP8,OMA1,TNFRSF10B,HMGB2,YWHAZ,BIRC2,NMT1,PSMA5,PSMD12,LY96,ACIN1,PSMA1,YWHAQ,GAS2,UBB,PSMB3,PSMB8,DCC,CFLAR,SEM1,BMF,PSMB1,CYCS,KPNA1,BIRC3,PSMD1,YWHAB,FNTA,BCL2L1,PSMA3,RIPK1,PSMB4,KPNB1,CTNNB1,PSMB7,PSMD14,HIST1H1A,AKT3,FASLG,PSMD7,PSMD3,PSMB10,XIAP,OPA1,PSME4 R-HSA-5339562|Uptake and actions of bacterial toxins |0.00690021084370636 |-4.97620331078689|31 |21 |0.00462046204620462 |4545 |10287 |CD9,FURIN,CALM1,HSP90AB1,EEF2,VAMP2,STX1B,TXNRD1,VAMP1,HSP90AA1,HBEGF,GUCY2C,PDCD6IP,MAP2K7,STX1A,MAP2K6,MAP2K3,CALM2,ANTXR1,ANTXR2,MAP2K1 R-HSA-71387 |Metabolism of carbohydrates |0.00707670529429225 |-4.95094683350077|296 |152 |0.0334433443344334 |4545 |10287 |NAGLU,GALT,PPP2CA,SLC9A1,CHST9,MDH2,B3GAT3,AKR1B1,RPE,SORD,UBA52,HS3ST2,LYVE1,TALDO1,KHK,PCK1,PFKP,CSGALNACT1,HSPG2,NDST2,SDC1,B3GAT2,ALDOB,GPC3,GLYCTK,SLC2A5,FBP1,CHIT1,HS3ST5,GCK,FMOD,PGLS,HS2ST1,G6PC,GAPDH,NUP85,GLB1,EPM2A,SLC5A9,CHST7,CHST5,GYG1,SLC5A10,PGM1,PHKB,GCKR,PYGB,SLC2A14,GLCE,VCAN,SLC37A4,PAPSS1,B4GALT2,PFKL,GYS2,STAB2,ALDH1A1,GPI,GBE1,CHST13,CHST15,B3GNT7,B3GNT2,NUP43,GOT1,ST3GAL1,CHST14,SLC35D2,SLC25A12,CHSY1,CHP1,MAN2C1,ADPGK,NHLRC1,ST3GAL4,GPC6,GYS1,NUP205,GUSB,ST3GAL2,AKR1A1,PYGL,HAS3,HS6ST1,RAE1,GALE,GOT2,B3GNT4,MIR671,PPP2R1B,XYLT2,SDC2,PGD,NUP58,ALDOA,SLC2A4,UBC,CHST3,MANBA,PGK2,PGM2,CALM2,NUP214,NUP35,RPIA,HEXB,FGF21,SLC25A1,NUP42,GPC5,PCK2,B3GALT6,NDST1,UBB,SLC26A1,G6PC2,HYAL3,MDH1,G6PC3,ARSB,CHST6,PPP1R3C,RANBP2,DSE,SLC25A10,NUP188,NUP210,SLC45A3,ST3GAL6,SDC3,NUP93,EXT1,PKM,UGP2,CALM1,SLC2A2,PAPSS2,HAS2,SLC25A13,HK2,SEH1L,GPC4,B4GALT5,BPGM,GPC1,HS3ST6,CRYL1,HMMR,SDC4,PRKACA,PGK1,SLC2A1 R-HSA-1660661|Sphingolipid de novo biosynthesis |0.00722613110186178 |-4.93005150334602|44 |28 |0.00616061606160616 |4545 |10287 |SPTSSA,FA2H,ACER1,SPTSSB,ACER3,DEGS2,SPHK2,SPTLC2,SPHK1,VAPA,VAPB,PLPP1,KDSR,PLPP3,ALDH3B1,SGPP1,ALDH3A2,PPM1L,CERS6,ACER2,CSNK1G2,SPTLC3,SGPL1,SGMS2,DEGS1,SGMS1,CERS2,CERS4 R-HSA-199992 |trans-Golgi Network Vesicle Budding |0.00786724780484461 |-4.84504698485 |73 |43 |0.00946094609460946 |4545 |10287 |DNM2,TGOLN2,CHMP2A,NAPA,SNX2,CPD,AP1M1,SH3D19,PIK3C2A,TXNDC5,PICALM,FTL,HIP1R,VAMP2,BLOC1S4,SORT1,APP,CLINT1,STX4,AP4E1,CLVS1,CTSZ,ARF1,AP1S2,VAMP8,CLVS2,PUM1,NECAP1,SNX9,TPD52L1,HSPA8,AP1S3,IGF2R,TBC1D8B,DTNBP1,ARRB1,SNX5,FTH1,SNAPIN,OCRL,RAB5C,AP4S1,TFRC R-HSA-421837 |Clathrin derived vesicle budding |0.00786724780484461 |-4.84504698485 |73 |43 |0.00946094609460946 |4545 |10287 |SNX2,CHMP2A,NAPA,TGOLN2,DNM2,TXNDC5,SH3D19,AP1M1,PIK3C2A,CPD,CLINT1,APP,VAMP2,HIP1R,BLOC1S4,SORT1,PICALM,FTL,AP1S2,ARF1,CLVS1,CTSZ,AP4E1,STX4,CLVS2,VAMP8,AP1S3,TPD52L1,NECAP1,SNX9,HSPA8,PUM1,DTNBP1,TBC1D8B,IGF2R,OCRL,RAB5C,TFRC,AP4S1,SNAPIN,FTH1,SNX5,ARRB1 R-HSA-1500931|Cell-Cell communication |0.00807324091375625 |-4.81920027710244|133 |73 |0.0160616061606161 |4545 |10287 |CDH17,CLDN14,PTK2,PIK3R1,CDH10,IQGAP1,JUP,PIK3CB,PAK1,CLDN22,PATJ,LAMB3,CLDN1,PARD6G,CDH2,CADM2,LAMA3,PARD6B,CLDN4,FBLIM1,PRKCI,TESK1,LIMS2,PLEC,PTPN11,NECTIN4,CDH18,ANG,FYB1,CLDN19,SPTAN1,MAPK14,ITGA6,CDH1,CDH5,CADM1,CTNNA1,PXN,SIRPA,CLDN12,SRC,CDH12,MPP5,FYN,CDH6,PIK3R2,PTK2B,WASL,CLDN23,TYROBP,ACTN4,MAPK13,ACTN1,DCC,ITGB1,RSU1,CDH4,DSCAML1,PARD3,NCK1,CASK,CDH11,NCK2,GRB2,AFDN,DST,NTN1,CTNNB1,ARHGEF6,F11R,SPTBN1,FERMT2,CLDN7 R-HSA-5654736|Signaling by FGFR1 |0.00834815685957173 |-4.78571449986564|50 |31 |0.00682068206820682 |4545 |10287 |PIK3R1,FGF3,SPRED1,GRB2,FLRT3,KRAS,FGF20,SPRED2,UBA52,SRC,FLRT1,SOS1,MAPK1,NRAS,PTPN11,BRAF,FRS2,FGF9,FGF2,FLRT2,FGFR1,FGF10,UBB,FGFRL1,SPRY2,FRS3,SHC1,UBC,FGF1,KL,PPP2CA R-HSA-73887 |Death Receptor Signalling |0.00834815685957173 |-4.78571449986564|50 |31 |0.00682068206820682 |4545 |10287 |USP4,TRAF1,BAG4,UBC,CASP10,SPPL2A,TAB1,TRAF2,IKBKG,TNFSF10,TAX1BP1,RIPK1,UBB,RBCK1,TAB2,OTUD7B,SPPL2B,TNFRSF10B,CLIP3,UBA52,CASP8,BIRC3,XIAP,BIRC2,FAS,TNFRSF1A,USP2,ADAM17,TAB3,FASLG,CFLAR R-HSA-109581 |Apoptosis |0.00836159984023858 |-4.78410550174454|172 |92 |0.0202420242024202 |4545 |10287 |TJP2,ROCK1,PSMB5,PSMC4,PSMA6,PPP1R13B,CASP9,BCAP31,DSP,GSN,DNM1L,PSMB9,PSMF1,PSMC2,LMNB1,DIABLO,UNC5A,LMNA,FAS,DSG2,DAPK1,DSG1,H1F0,PTK2,UBA52,TP73,TFDP2,PSMB11,PRKCD,YWHAG,STK24,HMGB1,CD14,BCL2L11,PSMA7,TNFSF10,DAPK2,TRAF2,ADD1,BBC3,UBC,BCL2,CDH1,HIST1H1C,MIR3191,SPTAN1,PAK2,BIRC2,HMGB2,YWHAZ,NMT1,PSMA5,CASP8,PLEC,TNFRSF10B,OMA1,GAS2,YWHAQ,UBB,PSMD12,ACIN1,LY96,PSMA1,BMF,SEM1,CFLAR,DCC,PSMB1,PSMB8,PSMB3,KPNA1,CYCS,BCL2L1,PSMA3,RIPK1,YWHAB,PSMD1,FNTA,PSMB7,CTNNB1,PSMB4,KPNB1,AKT3,FASLG,PSMD14,HIST1H1A,OPA1,XIAP,PSME4,PSMB10,PSMD3,PSMD7 R-HSA-73848 |Pyrimidine metabolism |0.00871846940490943 |-4.74231158342784|26 |18 |0.00396039603960396 |4545 |10287 |UMPS,UPP1,NT5C3A,MIR3658,UPP2,DHODH,PUDP,TK2,TYMP,DCK,AGXT2,UCK2,NT5E,NT5M,UCK1,DPYS,DCTD,UPB1 R-HSA-210991 |Basigin interactions |0.00871846940490943 |-4.74231158342784|26 |18 |0.00396039603960396 |4545 |10287 |SLC16A3,SLC7A9,ATP1B1,SLC7A7,ITGB1,SLC7A6,SLC7A8,ITGA6,SLC7A11,SLC7A5,CAV1,MAG,SLC7A10,PPIA,SLC3A2,ATP1B3,MIR6787,BSG R-HSA-5689896|Ovarian tumor domain proteases |0.00896287679853355 |-4.71466403226274|37 |24 |0.00528052805280528 |4545 |10287 |OTUD5,RHOA,IKBKG,DDX58,TNIP1,RIPK1,UBB,NOD2,RNF135,TRIM25,OTUD7A,NOD1,OTUD7B,TRAF3,RNF128,UBC,ESR1,OTUB1,UBE2D1,MAVS,RIPK2,OTUB2,UBA52,ZRANB1 R-HSA-438064 |Post NMDA receptor activation events |0.00896287679853355 |-4.71466403226274|37 |24 |0.00528052805280528 |4545 |10287 |RASGRF1,CAMK2G,ADCY1,CAMK2B,GRIN2A,CAMK2D,PDPK1,CALM2,ADCY8,BRAF,PRKACA,RPS6KA3,AKAP9,RPS6KA1,NEFL,MAPK1,CALM1,CAMK4,CAMK2A,RPS6KA2,ADCY3,RAF1,RASGRF2,CREB1 R-HSA-1592230|Mitochondrial biogenesis |0.00897349857327656 |-4.71347964848793|54 |33 |0.00726072607260726 |4545 |10287 |NCOA2,CARM1,TFB1M,PPARGC1B,MAPK14,TBL1X,PRKAG1,PRKAG2,POLG2,NRF1,NCOA1,MED1,SSBP1,PPARA,TFB2M,CYCS,CRTC1,POLRMT,CREBBP,PPARGC1A,ALAS1,PRKAB1,HELZ2,CRTC2,RXRA,CRTC3,CHD9,PRKAB2,SMARCD3,CREB1,NR1D1,TFAM,ESRRA R-HSA-1428517|The citric acid (TCA) cycle and respiratory electron transport |0.00904747208058743 |-4.70526988840155|158 |85 |0.0187018701870187 |4545 |10287 |TACO1,GLO1,NDUFV2,ATP5PF,NDUFA11,ATP5F1A,BSG,ATP5ME,NDUFS5,NDUFB6,ATP5MC2,NDUFA8,NDUFB9,NDUFA4,COX16,COX7A2L,NDUFAF6,OGDH,PDHX,COX5B,NDUFAF7,NDUFS7,NDUFC1,COX18,COX11,ACO2,ATP5F1C,ATP5MC1,ATP5MG,CYCS,SDHB,LDHAL6B,NDUFAB1,MPC1,NDUFB7,ETFB,SLC16A3,COX4I1,NDUFS4,NDUFA12,RXRA,PDPR,IDH2,NDUFB4,ATP5F1D,PDP2,PDK1,SUCLG1,COX8A,MIR6787,LRPPRC,COX14,COX5A,TMEM126B,ECSIT,DLST,HAGH,NDUFS1,UCP3,LDHA,NUBPL,COQ10B,COX20,UQCRC1,MDH2,COX6B1,CS,UQCRB,PDP1,PDK3,NDUFB11,ATP5PO,SUCLG2,PDK4,UQCRFS1,IDH3A,NDUFAF5,ATP5MC3,UQCRC2,COX6C,NDUFB3,COX6A1,D2HGDH,UQCR10,PPARD R-HSA-382551 |Transmembrane transport of small molecules |0.00943192479187881 |-4.66365508949824|677 |329 |0.0723872387238724 |4545 |10287 |ABCG2,CALM1,SLC22A8,SLC6A2,PSMB4,CP,SLC38A3,SEH1L,SLC27A1,LOC100506403,SLC1A3,ERLIN1,SLC3A1,SLC38A4,BSG,PSMD7,PSMD3,PRKACA,SLC17A5,SLC2A1,SLC33A1,SLC16A7,MCOLN1,ATP2A1,SLC7A1,SLC43A2,WNK2,SLC39A10,TF,G6PC3,RANBP2,SLC38A2,CAMK2G,ANKH,ATP6V1G1,SLC25A10,TRPM1,NUP210,NUP188,SLC45A3,ATP1A2,PSMB11,SLC47A1,EIF2S3,SLC22A11,SLC15A1,ABCC8,CALM2,NUP35,SLC35A2,ATP6V0D1,SLC6A14,ATP2B4,TUSC3,FGF21,SLC30A6,SLC46A1,ASIC1,SCNN1B,PSMB5,EIF2S2,ATP8A2,SLC7A8,CAMK2B,RAE1,ATP6V1D,LCN12,PRKAR1A,SLC38A1,SLC31A1,SLC29A3,ATP6V0A1,ATP6V1C1,NIPAL1,ABCA10,AHCYL2,BEST1,SLC5A5,SLCO4C1,SLC22A7,PSMB7,ABCA8,TRPM6,ANO3,SLC35C1,SLC14A2,DERL1,PSMB10,AQP4,HMOX1,NUP85,PSMD12,TSC22D3,GABRR2,GCKR,SLC5A10,SRI,SLC2A14,AQP9,SLC66A1,GNAS,PSMB3,SLC1A7,ADCY1,SLC13A5,TRPM7,ANO6,GNB5,TRPC4AP,UNC79,DMTN,ATP9B,SLC1A2,AQP3,ABCC2,TPCN1,SLC2A5,GCK,G6PC,ATP10B,PSMA5,RNF185,SLC26A7,SLC9B2,ASIC2,WNK3,SLC30A2,SLC12A7,ABCG8,ATP2B1,NIPAL3,FTL,SLC13A3,ERLIN2,SLC20A2,TTYH3,ATP6V0D2,SLC35A1,SLC9A1,ADCY8,ATP6V1G2,LCN2,SLC7A6,PSMC2,SLC6A6,SLC22A2,CYBRD1,SLC26A3,SGK1,ATP6V1C2,SLC35B4,SGK2,SLC4A3,NUP93,SLCO2B1,SLC6A12,ATP2B2,SLC2A2,HK2,RAB11FIP2,ABCD3,ABCD1,LCN1,STEAP3,CAMK2D,TRPV2,ABCA9,RNASEL,APOA1,PSME4,SLC11A1,SLC44A1,PSMA1,SLC4A5,ATP2C1,SLC4A7,ALB,SLC25A18,UBB,ATP2C2,SLC26A1,G6PC2,RAB11A,SLC7A7,CAMK2A,PSMB8,HTR3A,SLC2A9,SLCO1B3,SLC6A1,GNGT2,ATP6V0A4,SLC2A10,ATP6V1E2,SLC41A2,ATP6V0C,SLC20A1,NUP58,SLC2A8,SLC30A5,UBC,TFRC,SLC2A4,OS9,SLC22A3,ADCY3,ATP8B1,SLC7A11,NUP214,SLC47A2,FXYD2,GNG10,MIR6787,NUP42,GABRA2,SLC4A10,ATP11A,ABCC11,SLC34A2,ABCC4,RHBG,ADD3,ABCB4,ADCY9,RUNX1,WWP1,NUP205,TRPC1,FXYD1,SGK3,TRPM4,ANO10,RAF1,CLCN3,SLC17A8,SLC15A2,FKBP1B,SLC7A5,ATP1A1,SLC5A11,SLC6A5,ATP2A2,SLC38A5,SLC7A10,PSMD1,ATP1B1,SLC7A9,SLC13A2,PSMA3,MFSD4B,PEX3,NUP43,AQP8,NIPAL2,SLC9B1,ABCA4,SLC35D2,TRPV4,ATP2B3,PSMD14,SLC7A2,PEX19,ADCY7,SLC27A4,SLC22A17,SLC24A4,ABCG5,NEDD4L,SLC16A3,SLC5A9,SLC39A14,GNG7,SLC43A1,ABCC6,ERLEC1,SLC5A12,STOM,SLC37A4,SEM1,SLC40A1,SLC8A3,PSMB1,SLC9A8,NIPA2,SLCO3A1,ADCY4,SLC3A2,TRPM8,TRPM3,ABCC3,ATP11B,ABCC10,SLC1A5,PSMA7,SLC35D1,SLC6A7,SLC13A1,CLCN4,SLC11A2,SLC22A18,SLC1A4,FTH1,ADD1,SEL1L,SLC30A1,ABCC1,TRPC3,ATP6V0E1,GNG4,SLC22A16,GNB4,SLC28A3,PSMC4,SLC29A2,SLC36A2,PSMF1,PSMB9,ATP7B,PSMA6,BEST4,SLC2A11,ATP9A,SLC6A11,SLC25A26,TRPM2,ATP1B3,UBA52,SLC44A5,CTNS R-HSA-381070 |IRE1alpha activates chaperones |0.00950661900950997 |-4.65576698514161|58 |35 |0.0077007700770077 |4545 |10287 |XBP1,ERN1,SRPRB,ACADVL,SYVN1,LMNA,SEC61G,HDGF,KDELR3,EDEM1,GET3,WFS1,SEC62,PDIA5,WIPI1,CTDSP2,DCTN1,GSK3A,SEC63,HSPA5,TSPYL2,ATP6V0D1,GFPT1,DNAJB11,ZBTB17,DNAJC3,SHC1,ARFGAP1,EXTL3,ADD1,CXXC1,HYOU1,SEC61A1,GOSR2,TATDN2 R-HSA-1483213|Synthesis of PE |0.00965692523892524 |-4.64007997967325|14 |11 |0.00242024202420242 |4545 |10287 |MIR7109,ETNK2,ETNK1,ETNPPL,PISD,LPIN2,SELENOI,LPIN1,LPIN3,CHKA,CEPT1 R-HSA-877312 |Regulation of IFNG signaling |0.00965692523892524 |-4.64007997967325|14 |11 |0.00242024202420242 |4545 |10287 |PIAS1,JAK2,JAK1,SOCS3,PTPN2,IFNGR1,STAT1,PTPN11,IFNGR2,PTPN1,SOCS1 R-HSA-5675482|Regulation of necroptotic cell death |0.00965692523892524 |-4.64007997967325|14 |11 |0.00242024202420242 |4545 |10287 |TNFSF10,RIPK1,FASLG,CFLAR,TNFRSF10B,CASP8,BIRC3,XIAP,FAS,BIRC2,TRAF2 R-HSA-1483191|Synthesis of PC |0.00980672290166493 |-4.6246871181292 |28 |19 |0.00418041804180418 |4545 |10287 |ABHD3,CHKA,LPIN3,SLC44A1,LPIN1,PEMT,CSNK2A2,ACHE,LPCAT1,PCYT1A,CSNK2A1,MFSD2A,CEPT1,CSNK2B,PCTP,CHPT1,SLC44A5,PCYT1B,LPIN2 R-HSA-5658442|Regulation of RAS by GAPs |0.0106223991717469 |-4.5447903779717 |70 |41 |0.00902090209020902 |4545 |10287 |PSMD7,PSMB10,PSMD3,PSMA5,NRAS,PSME4,PSMD14,RASA2,SPRED2,KRAS,UBC,PSMB4,RASAL1,RASAL2,PSMB7,PSMD1,PSMA7,PSMB11,PSMA3,KBTBD7,UBA52,RASAL3,PSMB3,PSMB8,SPRED1,DAB2IP,SYNGAP1,MIR5004,SEM1,PSMC2,PSMB1,NF1,PSMF1,PSMB9,PSMA6,PSMC4,PSMD12,PSMA1,RASA3,PSMB5,UBB R-HSA-2151201|Transcriptional activation of mitochondrial biogenesis |0.0111520834028372 |-4.49612894625833|45 |28 |0.00616061606160616 |4545 |10287 |RXRA,CRTC3,CHD9,SMARCD3,POLG2,NRF1,NCOA1,CREB1,MED1,TFAM,NR1D1,SSBP1,ESRRA,PPARA,TFB2M,CYCS,CRTC1,POLRMT,NCOA2,CARM1,CREBBP,PPARGC1A,TFB1M,PPARGC1B,ALAS1,HELZ2,TBL1X,CRTC2 R-HSA-5687128|MAPK6/MAPK4 signaling |0.0112863837293257 |-4.48415825954131|90 |51 |0.0112211221122112 |4545 |10287 |PSMB7,AGO3,CDC14B,CDC42EP2,MAPK4,UBC,MAPK6,PSMB4,PSMA3,PSMB11,CDC42,PSMD1,PSMA7,HSPB1,PSMA5,PSME4,PRKACA,TNRC6C,PSMD7,PSMD3,PSMB10,FOXO3,PAK2,PAK3,PSMD14,IGF2BP1,PSMA6,PSMF1,PSMB9,AGO2,TNRC6A,PSMB5,UBB,KALRN,CCND3,XPO1,PSMA1,JUN,PSMD12,PSMC4,NCOA3,DNAJB1,UBA52,PSMB1,PAK1,SEM1,PSMC2,TNRC6B,ETV4,PSMB3,PSMB8 R-HSA-376176 |Signaling by Robo receptor |0.0117879813376105 |-4.44067479727637|32 |21 |0.00462046204620462 |4545 |10287 |ROBO2,ROBO1,PAK4,SOS1,GPC1,NCK1,PAK1,ENAH,CAP2,PAK2,PAK3,NCK2,ABL2,CLASP2,CLASP1,PFN1,PFN2,SRGAP1,EVL,CDC42,ABL1 R-HSA-8862803|Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |0.0124226820908774 |-4.3882312764445 |23 |16 |0.00352035203520352 |4545 |10287 |SOD2,CAPN1,CAST,LMNA,PRDX2,FOXO3,FASLG,LMNB1,CDK5R1,CDC25B,PRDX1,CAPN2,JUN,APP,CAPNS1,BCL2L11 R-HSA-8863678|Neurodegenerative Diseases |0.0124226820908774 |-4.3882312764445 |23 |16 |0.00352035203520352 |4545 |10287 |CAPN2,PRDX1,CDC25B,JUN,APP,BCL2L11,CAPNS1,SOD2,CAPN1,CAST,LMNA,PRDX2,LMNB1,FASLG,FOXO3,CDK5R1 R-HSA-5218859|Regulated Necrosis |0.0125476692308744 |-4.37822034930762|16 |12 |0.00264026402640264 |4545 |10287 |TNFRSF10B,CASP8,BIRC3,XIAP,FAS,BIRC2,TRAF2,TNFSF10,RIPK1,FASLG,MLKL,CFLAR R-HSA-5213460|RIPK1-mediated regulated necrosis |0.0125476692308744 |-4.37822034930762|16 |12 |0.00264026402640264 |4545 |10287 |BIRC3,FAS,TRAF2,BIRC2,XIAP,TNFRSF10B,CASP8,MLKL,FASLG,RIPK1,CFLAR,TNFSF10 R-HSA-8856828|Clathrin-mediated endocytosis |0.0125870951270144 |-4.3750831861408 |137 |74 |0.0162816281628163 |4545 |10287 |GRB2,SH3KBP1,VAMP8,SH3GL1,DAB2,WNT5A,COPS7A,ARPC5,LRP2,ARF6,TACR1,SYT11,LDLR,OCRL,ARFGAP1,COPS8,EPS15,PACSIN2,FNBP1L,ARRB1,ACTR2,AP2B1,VAMP3,TF,ITSN2,FZD4,AGTR1,STON2,DNM2,WASL,RAB5B,HIP1R,COPS7B,VAMP2,COPS5,UBB,PICALM,STAM,GRK3,EGF,BIN1,PACSIN3,NECAP1,SNX9,ARPC2,HSPA8,PACSIN1,KIAA0319,FNBP1,SLC2A8,AP2A1,AP2M1,IGF2R,RAB5C,TFRC,UBC,ARPC1A,HIP1,EPS15L1,AP2A2,CTTN,TGOLN2,ACTR3,APOB,UBA52,PIK3C2A,TRIP10,LDLRAP1,SCARB2,ITSN1,SYNJ2,GAPVD1,MIR6886,AP2S1 R-HSA-192105 |Synthesis of bile acids and bile salts |0.0126757334258194 |-4.36806586720898|34 |22 |0.00484048404840484 |4545 |10287 |AMACR,AKR1C1,CYP8B1,SCP2,HSD17B4,OSBPL2,CYP27A1,AKR1D1,NCOA2,PTGIS,BAAT,OSBPL9,AKR1C2,RXRA,NCOA1,SLC27A5,ACOX2,AKR1C3,NR1H4,OSBPL6,OSBPL3,SLC27A2 R-HSA-445355 |Smooth Muscle Contraction |0.0134948574414666 |-4.30544659637185|36 |23 |0.00506050605060506 |4545 |10287 |SORBS3,CALD1,CALM2,SORBS1,MYL10,ANXA6,ANXA1,ITGA1,MYL6B,MYL9,MYLK,DYSF,TPM3,MYL6,TPM4,ITGB5,MYH11,MYL12B,PXN,TPM1,CALM1,ANXA2,VCL R-HSA-2029482|Regulation of actin dynamics for phagocytic cup formation |0.013794028582393 |-4.28351949188638|61 |36 |0.00792079207920792 |4545 |10287 |FCGR2A,NCKAP1,ABI2,ARPC1A,DOCK1,HSP90AB1,CDC42,ACTB,ARPC5,NCK1,ABI1,CD247,ARPC2,MYO1C,WASF2,GRB2,CYFIP1,VAV3,VAV2,ABL1,MYH9,ACTG1,CYFIP2,MAPK1,FCGR3A,ACTR3,CRK,HSP90AA1,ELMO1,WASL,PTK2,ACTR2,WASF1,ARPC1B,MYO9B,PAK1 R-HSA-182971 |EGFR downregulation |0.013993087046688 |-4.26919185369697|25 |17 |0.00374037403740374 |4545 |10287 |SH3GL1,SH3KBP1,EGF,PTPRK,EPS15L1,GRB2,PTPN3,UBA52,SPRY1,UBB,CDC42,ARHGEF7,PTPN12,STAM,EPS15,UBC,SPRY2 R-HSA-1614635|Sulfur amino acid metabolism |0.013993087046688 |-4.26919185369697|25 |17 |0.00374037403740374 |4545 |10287 |TST,ADI1,GCLM,MAT1A,CNDP2,CSAD,ENOPH1,GOT1,AHCY,CTH,SQOR,MTAP,GCLC,MTRR,ETHE1,MTR,SLC25A10 R-HSA-5674400|Constitutive Signaling by AKT1 E17K in Cancer |0.013993087046688 |-4.26919185369697|25 |17 |0.00374037403740374 |4545 |10287 |GSK3A,PRR5,RPS6KB2,GSK3B,CASP9,NR4A1,TSC2,CREB1,MTOR,FOXO3,AKT3,RICTOR,MDM2,CDKN1A,PDPK1,AKT1S1,MAPKAP1 R-HSA-68867 |Assembly of the pre-replicative complex |0.0144474921925213 |-4.23723443017592|69 |40 |0.0088008800880088 |4545 |10287 |PSMA3,PSMB11,PSMD1,PSMA7,PSMB7,ORC6,PSMB4,UBC,MCM4,PSMD14,PSME4,PSMA5,MCM3,E2F2,PSMB10,PSMD3,PSMD7,MCM5,UBB,PSMB5,E2F3,PSMA1,PSMC4,PSMD12,ORC4,ORC2,PSMA6,PSMF1,PSMB9,CDC6,PSMB1,SEM1,PSMC2,GMNN,PSMB8,PSMB3,ORC5,CDT1,UBA52,ORC1 R-HSA-69304 |Regulation of DNA replication |0.0147819390057153 |-4.21434918088183|77 |44 |0.00968096809680968 |4545 |10287 |PSMD1,PSMA7,PSMB11,PSMA3,PSMB4,UBC,PSMB7,ORC6,PSMD14,MCM4,FZR1,MCM10,MCM5,PSMD3,PSMB10,PSMD7,E2F2,MCM3,PSME4,PSMA5,PSMD12,PSMC4,ORC4,PSMA1,E2F3,UBB,PSMB5,PSMB9,PSMF1,PSMA6,CCNA2,ORC2,PSMB8,PSMB3,CDKN1A,GMNN,SEM1,PSMC2,CDC6,PSMB1,ORC1,UBA52,ORC5,CDT1 R-HSA-450531 |Regulation of mRNA stability by proteins that bind AU-rich elements |0.0148155413991583 |-4.21207855463794|91 |51 |0.0112211221122112 |4545 |10287 |DIS3,TNPO1,PSMD14,NUP214,MAPK14,HSPA1A,YWHAZ,PSME4,PSMA5,MAPKAPK2,ZFP36,PSMB10,PSMD3,HSPA8,PSMD7,PRKCD,PSMB11,PABPC1,DCP1A,PSMA3,EXOSC9,YWHAB,HSPB1,PSMA7,PSMD1,PARN,PSMB7,PRKCA,PSMB4,UBC,PSMC2,SEM1,PSMB1,ZFP36L1,PSMB8,PSMB3,SET,UBA52,XPO1,UBB,PSMB5,PSMD12,PSMC4,XRN1,PSMA1,PSMA6,DCP2,EXOSC3,PSMB9,HNRNPD,PSMF1 R-HSA-109704 |PI3K Cascade |0.0148248133497375 |-4.21145292441454|79 |45 |0.0099009900990099 |4545 |10287 |EEF2K,EIF4B,FGF3,PDPK1,GRB2,RRAGC,PTPN11,FRS2,RPTOR,RRAGB,PDE3B,YWHAB,PRKAG2,PRKAG1,TRIB3,KL,TSC2,FGFR4,EIF4EBP1,FGF1,FGF19,RHEB,EIF4E,FGF20,TLR9,PIK3R1,PIK3CB,AKT1S1,LAMTOR4,STRADA,KLB,PRKAB1,PIK3C3,PIK3R2,FGF9,FGFR3,FGF2,FGFR2,FGFR1,FGF10,CAB39,PRKAA1,PRKAB2,MTOR,IRS1 R-HSA-190236 |Signaling by FGFR |0.0148445911953011 |-4.21011970935368|89 |50 |0.011001100110011 |4545 |10287 |KL,FGFR4,FGFRL1,POLR2E,UBC,FGF1,SHC1,SPRY2,FGFBP3,TIA1,PTPN11,NRAS,POLR2A,FRS2,RBFOX2,MIR6773,KRAS,SPRED2,FGF3,GTF2F2,GRB2,HNRNPM,HNRNPF,TIAL1,PPP2CA,PTBP1,FRS3,UBB,FGFR2,POLR2D,FGFR1,FLRT2,FGF10,BRAF,FGFR3,FGF2,FGF9,HNRNPH1,SRC,UBA52,MAPK1,SOS1,FLRT1,FGF19,FGF20,PIK3R1,GTF2F1,KLB,SPRED1,FLRT3 R-HSA-351202 |Metabolism of polyamines |0.0148636815247763 |-4.20883452308366|87 |49 |0.0107810781078108 |4545 |10287 |NMRAL1,ASL,OTC,PSMD14,AMD1,PSMD3,PSMB10,AZIN2,PSMD7,PSME4,PSMA5,SLC6A7,PSMA7,PSMD1,PSMA3,SLC6A12,ADI1,PSMB11,GATM,GOT1,PSMB4,ASS1,PSMB7,OAZ2,SLC6A11,PSMB8,SAT1,PSMB3,MTAP,PSMB1,SEM1,PSMC2,CPS1,SMOX,SLC25A15,GAMT,ARG1,PSMA1,PSMC4,PSMD12,AGMAT,CKB,PSMB5,SMS,OAZ1,PSMB9,PSMF1,ENOPH1,PSMA6 R-HSA-5675221|Negative regulation of MAPK pathway |0.0149343635432715 |-4.20409044333618|40 |25 |0.0055005500550055 |4545 |10287 |DUSP10,YWHAB,PPP5C,DUSP6,UBB,MARK3,RAF1,UBC,BRAP,PPP2CA,DUSP1,KSR1,DUSP16,KRAS,MAP2K1,PPP2R5A,DUSP5,UBA52,DUSP9,MAPK1,PEBP1,DUSP7,BRAF,NRAS,PPP2R1B R-HSA-210993 |Tie2 Signaling |0.01527124936902 |-4.18178334456417|18 |13 |0.00286028602860286 |4545 |10287 |GRB7,TEK,KRAS,GRB2,PIK3CB,PIK3R1,PIK3R2,GRB14,NRAS,PTPN11,SHC1,SOS1,ANGPT4 R-HSA-3928662|EPHB-mediated forward signaling |0.0155599625890496 |-4.16305416453751|42 |26 |0.00572057205720572 |4545 |10287 |ARHGEF28,ROCK2,ACTR2,PAK1,ARPC1B,ACTR3,YES1,SRC,ARPC2,ARPC5,PTK2,FYN,WASL,RHOA,CDC42,SDC2,EFNB1,ACTB,LYN,ACTG1,ITSN1,ROCK1,KALRN,EPHB4,ARPC1A,LIMK2 R-HSA-5617833|Cilium Assembly |0.0159537848246814 |-4.13805918481736|192 |100 |0.022002200220022 |4545 |10287 |SSTR3,CEP57,KIF3B,CLASP1,CEP152,CSNK1E,DYNC1I2,DYNLRB1,BBS1,CEP72,KIF17,CETN2,PCNT,HAUS4,IFT20,WDR60,IFT172,CCT5,IFT22,BBS12,HSP90AA1,ASAP1,SEPTIN2,PLK4,IFT88,ODF2,PCM1,TMEM216,BBS9,MKS1,CEP164,RPGRIP1L,KIF3C,YWHAG,NPHP1,RP2,CEP97,TTBK2,NDE1,TCTN1,IFT43,NEDD1,BBS2,EXOC7,HAUS6,MARK4,TTC30A,MKKS,CNGA2,IFT80,TRAF3IP1,SCLT1,RAB11A,IQCB1,DYNLRB2,RAB11FIP3,DCTN1,IFT122,CEP63,CNTRL,CCP110,CNGB1,CKAP5,AKAP9,HAUS3,IFT57,LZTFL1,CLUAP1,MAPRE1,CCT3,CDK5RAP2,CEP89,CCT2,EXOC6,IFT52,CYS1,RHO,CEP192,DCTN2,DYNC2LI1,EXOC8,CEP250,MIR484,TUBB,PRKACA,CC2D2A,NEK2,DYNC1H1,NINL,CEP162,CEP76,CEP83,RAB3IP,CEP78,PLK1,TNPO1,TTC8,CEP70,IFT81,TTC21B R-HSA-114608 |Platelet degranulation |0.0161225902407602 |-4.12753386990141|132 |71 |0.0156215621562156 |4545 |10287 |VCL,LGALS3BP,IGF1,RAB27B,SERPINA3,SPARC,VEGFD,CD36,PFN1,ALDOA,HSPA5,ORM2,A2M,THBS1,CALM2,EGF,QSOX1,CFD,MIR6843,APOH,F13A1,SRGN,HABP4,OLA1,ABCC4,ORM1,STXBP2,IGF2,ITGB3,CLU,SELENOP,VEGFA,SERPINA1,FGA,SCCPDH,PPIA,PSAP,GTPBP2,KNG1,CD9,TIMP3,SERPINF2,TEX264,FGG,CALM1,SOD1,PROS1,PDGFA,FERMT3,APOA1,ANXA5,PCYOX1L,WDR1,VWF,APP,PHACTR2,ALB,CHID1,FGB,AHSG,LHFPL2,FN1,SERPINE1,LAMP2,CDC37L1,PECAM1,ACTN4,TGFB3,F5,TF,ACTN1 R-HSA-917937 |Iron uptake and transport |0.016126868025212 |-4.12726857648522|44 |27 |0.00594059405940594 |4545 |10287 |TF,ATP6V0D1,ATP6V1G2,STEAP3,ATP6V0D2,SLC40A1,ATP6V0E1,ATP6V1D,LCN2,ATP6V0A4,CYBRD1,SLC22A17,ATP6V1G1,ATP6V1C1,HMOX1,ATP6V0C,ATP6V0A1,ATP6V1C2,ATP6V1E2,SLC46A1,ABCG2,MCOLN1,FTL,CP,SLC11A2,TFRC,FTH1 R-HSA-975634 |Retinoid metabolism and transport |0.016126868025212 |-4.12726857648522|44 |27 |0.00594059405940594 |4545 |10287 |APOB,LRP2,GPC1,APOA1,GPC5,LRP1,LDLR,SDC4,AKR1C1,APOC3,APOA2,GPC3,HSPG2,RBP4,PLB1,APOC2,RDH11,MIR6886,LRP8,GPC4,APOM,SDC1,SDC2,APOA4,SDC3,AKR1C3,GPC6 R-HSA-442742 |CREB phosphorylation through the activation of Ras |0.0167702278440357 |-4.08815011683289|29 |19 |0.00418041804180418 |4545 |10287 |RPS6KA3,BRAF,NEFL,RPS6KA1,MAPK1,AKAP9,GRIN2A,CAMK2B,CAMK2G,RASGRF1,CALM2,PDPK1,CAMK2D,RPS6KA2,CAMK2A,CREB1,RASGRF2,RAF1,CALM1 R-HSA-453274 |Mitotic G2-G2/M phases |0.0169465854591184 |-4.07768891328864|184 |96 |0.0211221122112211 |4545 |10287 |PCNT,CETN2,E2F3,PSMC4,CEP72,FBXW11,PSMB5,CSNK1E,CEP152,PSMF1,DYNC1I2,PSMB9,CLASP1,CEP57,CCNA2,CDC25B,PSMA6,PPP2CA,ODF2,CDKN1A,PPP1CB,PHLDA1,PSMC2,PLK4,PPP2R2A,HSP90AA1,UBA52,MYBL2,HAUS4,PPP2R1B,TPX2,PSMA7,TUBGCP5,LIN52,YWHAG,PSMB11,CEP164,UBC,LIN37,PCM1,HAUS6,NEDD1,CENPF,NDE1,EP300,PSMA5,NUMA1,CCNH,PSMA1,CCP110,PSMD12,CEP63,CNTRL,PPP1R12B,UBB,XPO1,DCTN1,LIN54,PSMB8,PSMB3,MAPRE1,PSMB1,HAUS3,SEM1,AKAP9,CKAP5,BTRC,SKP1,CEP250,MIR484,HSP90AB1,PSMD1,CEP192,DCTN2,PSMA3,PSMB4,CUL1,PSMB7,WEE1,CDK5RAP2,PSMD14,CEP70,CEP78,PLK1,BORA,PSMB10,PSMD3,PSMD7,CEP76,NEK2,NINL,DYNC1H1,PSME4,TUBB,PRKACA,HMMR R-HSA-69275 |G2/M Transition |0.0172029022235125 |-4.06267717547155|182 |95 |0.0209020902090209 |4545 |10287 |UBB,PPP1R12B,LIN54,XPO1,DCTN1,CCNH,PSMA1,CCP110,CNTRL,CEP63,PSMD12,BTRC,SKP1,AKAP9,CKAP5,PSMB1,MAPRE1,SEM1,HAUS3,PSMB3,PSMB8,WEE1,PSMB7,CDK5RAP2,PSMB4,CUL1,CEP192,PSMA3,DCTN2,MIR484,CEP250,PSMD1,HSP90AB1,NINL,NEK2,PSME4,DYNC1H1,TUBB,HMMR,PRKACA,PSMD7,PSMD3,PSMB10,CEP76,PLK1,CEP78,BORA,PSMD14,CEP70,CDC25B,CCNA2,CEP57,PPP2CA,PSMA6,PSMF1,PSMB9,DYNC1I2,CEP152,CSNK1E,CLASP1,PSMB5,FBXW11,CEP72,PCNT,CETN2,PSMC4,MYBL2,PPP2R1B,HAUS4,UBA52,PPP2R2A,HSP90AA1,PLK4,PSMC2,CDKN1A,ODF2,PHLDA1,PPP1CB,LIN37,PCM1,UBC,CEP164,YWHAG,LIN52,TUBGCP5,PSMB11,TPX2,PSMA7,PSMA5,NUMA1,CENPF,EP300,NDE1,HAUS6,NEDD1 R-HSA-70614 |Amino acid synthesis and interconversion (transamination) |0.0179784371828127 |-4.01858217347098|31 |20 |0.0044004400440044 |4545 |10287 |GLS2,PHGDH,ASPG,SERINC2,SERINC3,SERINC5,KYAT1,GOT1,PYCR2,GADL1,ALDH18A1,ASNS,PSPH,GPT2,PYCR1,GOT2,GLS,PSAT1,OAT,GPT R-HSA-2022928|HS-GAG biosynthesis |0.0179784371828127 |-4.01858217347098|31 |20 |0.0044004400440044 |4545 |10287 |SDC3,EXT1,SDC2,GPC6,NDST1,HSPG2,NDST2,SDC1,GPC4,SLC35D2,GPC3,GLCE,HS6ST1,GPC1,HS3ST6,HS3ST5,HS3ST2,SDC4,HS2ST1,GPC5 R-HSA-5654687|Downstream signaling of activated FGFR1 |0.0179784371828127 |-4.01858217347098|31 |20 |0.0044004400440044 |4545 |10287 |FGF10,FGFR1,FLRT2,KL,FGF1,FRS3,SHC1,FGF20,KRAS,FLRT3,GRB2,FGF3,PIK3R1,FGF2,FRS2,FGF9,NRAS,PTPN11,SOS1,FLRT1 R-HSA-381038 |XBP1(S) activates chaperone genes |0.0184766750838767 |-3.99124614865973|56 |33 |0.00726072607260726 |4545 |10287 |SEC61G,LMNA,KDELR3,HDGF,XBP1,ACADVL,SYVN1,SRPRB,WIPI1,PDIA5,SEC62,CTDSP2,GSK3A,DCTN1,EDEM1,WFS1,GET3,DNAJB11,GFPT1,ATP6V0D1,ZBTB17,SEC63,TSPYL2,CXXC1,HYOU1,TATDN2,GOSR2,SEC61A1,SHC1,EXTL3,ARFGAP1,DNAJC3,ADD1 R-HSA-4641257|Degradation of AXIN |0.0184766750838767 |-3.99124614865973|56 |33 |0.00726072607260726 |4545 |10287 |UBC,PSMB4,AXIN1,TNKS2,PSMB7,AXIN2,PSMD1,PSMA7,PSMA3,PSMB11,PSMD7,PSMD3,PSMB10,PSMA5,PSME4,PSMD14,PSMF1,PSMB9,TNKS,PSMA6,PSMA1,PSMC4,PSMD12,RNF146,PSMB5,UBB,UBA52,SMURF2,PSMB3,PSMB8,PSMB1,PSMC2,SEM1 R-HSA-109582 |Hemostasis |0.0185153681825795 |-3.98915417917671|632 |305 |0.0671067106710671 |4545 |10287 |KIF26B,PTK2,AKAP10,ANGPT4,ATP1B3,KNG1,PIK3CB,KIF13B,PPP2CA,F13A1,ADRA2C,SERPINB6,SERPINB2,PRKCE,OLA1,STXBP2,ORM2,GNB4,IRF2,RCOR1,MGLL,GNG4,TRPC3,DGKE,CAV1,GNA14,SPARC,NOS1,KIF3C,SERPIND1,LGALS3BP,KIF9,CSK,PDE3B,TNFRSF10D,RHOA,TREM1,DGKZ,SERPINE1,SLC3A2,RHOG,SOS1,SRC,PDE11A,SLC8A3,F5,PCYOX1L,GNG7,STX4,ANXA2,PIK3R3,F7,DOCK11,SLC16A3,MFN2,APP,KLC2,ITGB2,P2RX4,ABHD6,ATP2B3,PHF21A,CD99,MAFK,ITGAM,DGKI,SLC7A9,P2RX7,PROS1,INPP5D,GNAI1,TIMP3,FGG,ATP1B1,PSAP,PROC,SLC7A10,SCCPDH,KIF1B,ITGA1,ATP2A2,YES1,EHD2,MYB,SLC7A5,GYPC,NFE2,HABP4,RAF1,IGF2,ORM1,ABCC4,PRKCH,ITGA2,A2M,DOCK5,MIR4687,EP300,MIR6787,KIF2B,CFD,ITGA6,RASGRP2,MIR6843,GNG10,HMG20B,KIFC1,SLC7A11,MAPK14,SERPINA3,DGKD,TBXA2R,ALDOA,CD36,SIRPA,PRKCZ,FYN,GNGT2,JMJD1C,ACTN1,SERPINA5,WDR1,CABLES1,SLC7A7,GNAI2,VWF,SH2B2,GP1BA,ALB,GATA4,CAPZA2,PICK1,FERMT3,APOA1,GPC1,PPP2R5A,AKAP1,DGKK,PDPK1,VPREB1,CD9,TEK,ATP2B2,SDC3,PIK3CG,PDE9A,CEACAM8,TFPI,ADRA2A,CABLES2,SERPINA1,ABHD12,ITPR2,SERPINB8,SLC7A6,PIK3R1,SRGN,HDAC2,APOH,KIF3B,ITPR3,CLU,ITGB3,SELENOP,ATP2B1,YWHAZ,HIST1H3J,PTPN11,PRCP,DOCK6,HSPA5,THBS1,SDC1,SERPINE2,RAB27B,LRP8,PRKCA,CD99L2,IGF1,HIST1H3C,GNB5,SH2B3,KIF4B,F2,DAGLB,LAMP2,FN1,CDC37L1,AHSG,GLG1,CHID1,CRK,MAFF,P2RX3,JAK2,CREBBP,ITGAL,GNAS,MAG,DOCK4,SELPLG,SRI,GRB14,F2RL3,EHD1,MIR4738,GNAI3,RHOB,KCNMA1,PTPN1,DGKQ,NRAS,DGKA,IL3,KIF20A,PAFAH2,AKT3,WEE1,DOCK3,SHC1,IRF1,JAML,TEX264,CDC42,PPIA,PPP2R1B,FGA,F10,VEGFA,PRKAR1A,APOB,ORAI1,F11,SLC7A8,KIF27,PLCG2,KIF5B,KLC4,GTPBP2,FGR,VAV2,ZFPM1,GRB7,MIF,LYN,BCAR1,PIK3R5,CXADR,TNFRSF10B,ATP2B4,GAB2,ITGAX,CALM2,QSOX1,MPL,EGF,RAD51B,GNA12,VCL,MERTK,PRKCD,VEGFD,PFN1,CAPZB,SDC2,PIK3R2,FGB,MAPK1,LHFPL2,PECAM1,ACTN4,TGFB3,TF,SIN3A,SERPINC1,TSPAN7,RAPGEF4,VAV3,ITGB1,ANXA5,PHACTR2,ATP2A1,ABL1,SDC4,KIF21A,PRKACA,ITPK1,BSG,SELE,JAK1,KRAS,KIF16B,MRVI1,GRB2,ITPR1,RACGAP1,F11R,DOCK1,ARRB1,KIF18B,VPS45,SOD1,PDGFA,SERPINF2,CALM1 R-HSA-453279 |Mitotic G1-G1/S phases |0.0186520510172894 |-3.98179916482163|143 |76 |0.0167216721672167 |4545 |10287 |MCM10,E2F5,E2F2,PSMA5,SKP2,MCM4,UBC,CDC7,RBL2,LIN37,ORC6,PSMA7,LIN52,POLE4,CCND1,UBA52,PPP2R2A,TFDP2,CDK4,PPP2R1B,MYBL2,CDKN1A,PSMC2,RPA2,DYRK1A,PSMB9,PSMF1,PSMA6,PPP2CA,CCNA2,ORC2,PSMC4,E2F3,CDKN2B,PCNA,RPA3,PSMB5,RPA1,MCM5,PSMD3,PSMB10,PSMD7,MCM3,PSMD14,PRIM2,AKT3,PSMB4,CUL1,CCNE1,PSMB7,WEE1,PSMD1,PPP2R3B,PSMA3,ORC1,DHFR,CDKN2D,ORC5,RBL1,SKP1,CDT1,PSMB8,PSMB3,CDK6,SEM1,PSMB1,CDC6,POLE3,PSMD12,ORC4,CCNH,PSMA1,CCND3,LIN54,UBB,TK2 R-HSA-68827 |CDT1 association with the CDC6:ORC:origin complex |0.0189321674280285 |-3.96689282332477|60 |35 |0.0077007700770077 |4545 |10287 |PSMB11,PSMA3,PSMA7,PSMD1,PSMB7,ORC6,PSMB4,UBC,PSMD14,PSME4,PSMA5,PSMB10,PSMD3,PSMD7,UBB,PSMB5,PSMD12,PSMC4,ORC4,PSMA1,PSMA6,ORC2,PSMB9,PSMF1,PSMC2,SEM1,CDC6,PSMB1,PSMB8,PSMB3,GMNN,ORC5,CDT1,ORC1,UBA52 R-HSA-2565942|Regulation of PLK1 Activity at G2/M Transition |0.0192923505278097 |-3.94804660734636|90 |50 |0.011001100110011 |4545 |10287 |CEP192,DCTN2,YWHAG,MIR484,CEP250,CDK5RAP2,PCM1,UBC,CEP164,CUL1,BORA,NEDD1,PLK1,HAUS6,CEP78,CEP70,PRKACA,TUBB,NEK2,NINL,DYNC1H1,CEP76,NDE1,DCTN1,FBXW11,CEP72,PPP1R12B,UBB,CNTRL,CEP63,CCP110,PCNT,CETN2,CEP57,CLASP1,DYNC1I2,CEP152,CSNK1E,PLK4,HAUS3,MAPRE1,PPP1CB,ODF2,SKP1,BTRC,HAUS4,CKAP5,HSP90AA1,UBA52,AKAP9 R-HSA-76005 |Response to elevated platelet cytosolic Ca2+ |0.0193847256252654 |-3.94326986193076|137 |73 |0.0160616061606161 |4545 |10287 |KNG1,GTPBP2,SCCPDH,PSAP,PPIA,FGA,SERPINA1,VEGFA,SELENOP,CLU,ITGB3,IGF2,ORM1,STXBP2,ABCC4,OLA1,HABP4,SRGN,F13A1,APOH,MIR6843,CFD,QSOX1,EGF,CALM2,THBS1,A2M,ORM2,HSPA5,CD36,ALDOA,PFN1,VEGFD,SPARC,PRKCA,SERPINA3,RAB27B,IGF1,LGALS3BP,VCL,ACTN1,F5,TF,PECAM1,ACTN4,TGFB3,CDC37L1,SERPINE1,FN1,LAMP2,LHFPL2,FGB,AHSG,CHID1,PHACTR2,ALB,APP,STX4,VWF,WDR1,PCYOX1L,ANXA5,APOA1,FERMT3,PDGFA,PROS1,SOD1,FGG,CALM1,TEX264,TIMP3,SERPINF2,CD9 R-HSA-68874 |M/G1 Transition |0.0194545012186585 |-3.93967681056852|86 |48 |0.0105610561056106 |4545 |10287 |PSMA3,PSMB11,PSMA7,PSMD1,ORC6,PSMB7,CDC7,UBC,PSMB4,PRIM2,MCM4,PSMD14,PSMA5,PSME4,E2F2,MCM3,PSMD7,PSMB10,PSMD3,MCM5,RPA1,MCM10,RPA3,PSMB5,UBB,PSMA1,E2F3,ORC4,PSMD12,PSMC4,ORC2,PSMA6,PSMF1,PSMB9,POLE3,RPA2,CDC6,PSMB1,PSMC2,SEM1,GMNN,PSMB3,PSMB8,CDT1,ORC5,UBA52,ORC1,POLE4 R-HSA-69002 |DNA Replication Pre-Initiation |0.0194545012186585 |-3.93967681056852|86 |48 |0.0105610561056106 |4545 |10287 |PSMB3,PSMB8,GMNN,SEM1,PSMC2,PSMB1,RPA2,CDC6,ORC1,POLE4,UBA52,CDT1,ORC5,ORC4,PSMD12,PSMC4,PSMA1,E2F3,PSMB5,RPA3,UBB,PSMB9,PSMF1,POLE3,PSMA6,ORC2,PSMD14,PRIM2,MCM4,RPA1,MCM5,MCM10,PSMD7,PSMB10,PSMD3,MCM3,E2F2,PSMA5,PSME4,PSMA7,PSMD1,PSMB11,PSMA3,UBC,PSMB4,CDC7,ORC6,PSMB7 R-HSA-1169091|Activation of NF-kappaB in B cells |0.0194758666614682 |-3.93857918698476|68 |39 |0.00858085808580858 |4545 |10287 |PSMB1,PSMC2,NFKBIB,SEM1,CARD11,PSMB8,PSMB3,BTRC,SKP1,UBA52,UBB,FBXW11,PSMB5,PSMA1,PSMC4,PSMD12,PSMA6,PSMB9,PSMF1,MALT1,PSMD14,PSME4,PSMA5,PSMD3,PSMB10,PSMD7,PSMA3,NFKB1,PSMB11,NFKBIA,IKBKG,PSMD1,PSMA7,PSMB7,CUL1,PSMB4,BCL10,UBC,REL R-HSA-3371453|Regulation of HSF1-mediated heat shock response |0.0195476162203661 |-3.93490193244722|70 |40 |0.0088008800880088 |4545 |10287 |HSPA8,HSPA5,NUP42,MAPKAPK2,RPA1,SIRT1,ATR,HSPA12A,NUP35,HSPA1A,NUP214,NUP43,HSPA4L,RPS19BP1,SEH1L,DNAJB6,HSPA13,HSPA1B,GSK3B,NUP93,HSPA9,HSPA12B,NUP58,DNAJB1,MAPK1,NUP188,NUP210,ATM,BAG3,DNAJC2,HSPH1,RPA2,RAE1,HSPA7,RANBP2,BAG4,NUP85,NUP205,HSPA6,RPA3 R-HSA-69300 |Removal of licensing factors from origins |0.0196268172808288 |-3.9308584193038 |74 |42 |0.00924092409240924 |4545 |10287 |PSME4,PSMA5,MCM3,PSMD3,PSMB10,PSMD7,MCM10,MCM5,MCM4,FZR1,PSMD14,PSMB7,ORC6,PSMB4,UBC,PSMA3,PSMB11,PSMA7,PSMD1,ORC5,CDT1,UBA52,ORC1,PSMB1,CDC6,PSMC2,SEM1,GMNN,CDKN1A,PSMB8,PSMB3,CCNA2,ORC2,PSMA6,PSMF1,PSMB9,UBB,PSMB5,PSMA1,PSMC4,PSMD12,ORC4 R-HSA-6802948|Signaling by high-kinase activity BRAF mutants |0.0200571113050419 |-3.90917150955742|35 |22 |0.00484048404840484 |4545 |10287 |FGG,YWHAB,CSK,ITGB3,MARK3,RAF1,VCL,ARRB1,VWF,KSR2,KSR1,IQGAP1,KRAS,MAP2K1,SRC,MAPK1,PEBP1,FGB,BRAF,NRAS,FN1,FGA R-HSA-389357 |CD28 dependent PI3K/Akt signaling |0.020065184052931 |-3.90876910247049|22 |15 |0.0033003300330033 |4545 |10287 |PIK3R3,MAP3K14,MAPKAP1,CD80,MTOR,FYN,MAP3K8,TRIB3,PIK3R2,PDPK1,RICTOR,PIK3R1,PRR5,AKT3,CD28 R-HSA-1483206|Glycerophospholipid biosynthesis |0.0203727168366936 |-3.89355868322887|129 |69 |0.0151815181518152 |4545 |10287 |PGS1,CDS2,CHPT1,GPAT3,PLA2G6,CSNK2B,ALDH7A1,CRLS1,CSNK2A2,PISD,PLA2G4C,PLB1,SLC44A1,PLD1,GPCPD1,ABHD3,GPD1,PCYT1B,LPIN2,GNPAT,PCYT1A,LPCAT1,HADHB,MFSD2A,ETNK2,PNPLA2,CDIPT,ACHE,AGPAT3,GPD1L,PLA2G4E,AGPAT4,ETNK1,SLC44A5,PNPLA8,HADHA,OSBPL8,CEPT1,MIR7109,PLA2G2A,ETNPPL,GPAT2,CPNE1,CHDH,PITPNM2,PITPNB,LPIN1,GPAT4,PLAAT5,GPAM,MGLL,PLA2G1B,MBOAT1,LCLAT1,AGPAT1,DGAT1,SELENOI,PCTP,PNPLA3,CSNK2A1,MIR6848,PEMT,CPNE6,SARDH,DMGDH,AGPAT2,PLAAT2,LPIN3,CHKA R-HSA-69231 |Cyclin D associated events in G1 |0.02172833491696 |-3.82913811365248|39 |24 |0.00528052805280528 |4545 |10287 |CDK4,TFDP2,UBA52,PPP2R2A,CDKN2D,CCND1,E2F5,E2F2,PPP2R1B,SKP1,RBL1,CDKN1A,CDK6,SKP2,UBC,CUL1,PPP2CA,RBL2,E2F3,CCNH,UBB,CCND3,CDKN2B,PPP2R3B R-HSA-69236 |G1 Phase |0.02172833491696 |-3.82913811365248|39 |24 |0.00528052805280528 |4545 |10287 |E2F5,CCND1,CDKN2D,PPP2R2A,UBA52,CDK4,TFDP2,RBL1,SKP1,E2F2,PPP2R1B,SKP2,CDK6,CDKN1A,CUL1,UBC,RBL2,PPP2CA,E2F3,CCNH,CDKN2B,PPP2R3B,CCND3,UBB R-HSA-6802946|Signaling by moderate kinase activity BRAF mutants |0.02172833491696 |-3.82913811365248|39 |24 |0.00528052805280528 |4545 |10287 |MARK3,RAF1,VCL,BRAP,ARRB1,VWF,FGG,YWHAB,CSK,ITGB3,SRC,MAPK1,FGB,PEBP1,BRAF,NRAS,FN1,FGA,KSR2,KSR1,IQGAP1,KRAS,MAP2K1,JAK2 R-HSA-6802955|Paradoxical activation of RAF signaling by kinase inactive BRAF |0.02172833491696 |-3.82913811365248|39 |24 |0.00528052805280528 |4545 |10287 |BRAP,ARRB1,VWF,MARK3,RAF1,VCL,ITGB3,FGG,CSK,YWHAB,NRAS,BRAF,FGA,FN1,SRC,MAPK1,PEBP1,FGB,KRAS,MAP2K1,JAK2,KSR2,KSR1,IQGAP1 R-HSA-193807 |Synthesis of bile acids and bile salts via 27-hydroxycholesterol |0.0217894170726884 |-3.82633088243997|15 |11 |0.00242024202420242 |4545 |10287 |NR1H4,PTGIS,AKR1C2,AKR1C3,AKR1D1,CYP27A1,NCOA2,NCOA1,CYP8B1,AKR1C1,RXRA R-HSA-391903 |Eicosanoid ligand-binding receptors |0.0217894170726884 |-3.82633088243997|15 |11 |0.00242024202420242 |4545 |10287 |TBXA2R,OXER1,PTGDR2,LTB4R,PTGER1,PTGER2,LTB4R2,GPR17,CYSLTR2,PTGER4,PTGFR R-HSA-191273 |Cholesterol biosynthesis |0.022120074426425 |-3.81126973766707|24 |16 |0.00352035203520352 |4545 |10287 |HSD17B7,HMGCR,MSMO1,FDFT1,NSDHL,TM7SF2,SC5D,LBR,IDI1,ACAT2,FDPS,MVK,DHCR24,DHCR7,GGPS1,CYP51A1 R-HSA-442755 |Activation of NMDA receptor upon glutamate binding and postsynaptic events |0.0224281530865304 |-3.79743827505601|41 |25 |0.0055005500550055 |4545 |10287 |CALM1,RASGRF2,RAF1,ADCY3,CREB1,CAMK2A,CAMK4,RPS6KA2,GRIA3,PDPK1,CAMK2D,CALM2,ADCY8,RASGRF1,GRIN2A,CAMK2G,ADCY1,CAMK2B,AKAP9,MAPK1,NEFL,RPS6KA1,BRAF,RPS6KA3,PRKACA R-HSA-211945 |Phase 1 - Functionalization of compounds |0.0228160010737181 |-3.78029318769038|109 |59 |0.012981298129813 |4545 |10287 |CYP51A1,ACSS2,ADH6,AHR,CYP8B1,ADH5,BPHL,PTGIS,TBXAS1,CYP3A43,CYP27B1,CYP27A1,ALDH1B1,CYP26C1,MIR4651,ARNT,NCOA2,POMC,NCOA1,CYP2C9,POR,CYB5B,HSP90AB1,MARC1,CYP11B2,CYP2B6,CYP2A6,CYP4F12,SMOX,ADH4,ADH7,CYP2C8,CYP3A4,ALDH1A1,CYP2R1,FDX1,EPHX1,CYP4F3,MARC2,CES1,MAOA,NQO2,CYP3A7-CYP3A51P,ACSS1,FDXR,CYP2J2,ALDH2,RXRA,CYP24A1,CYP2C18,CYP26A1,CYP1A1,NR1H4,AOC3,MAOB,CYP26B1,CYP19A1,CYP2S1,CYP2W1 R-HSA-5362517|Signaling by Retinoic Acid |0.0230462961464585 |-3.77025021024036|43 |26 |0.00572057205720572 |4545 |10287 |ALDH8A1,PDK1,CYP26C1,DHRS3,ALDH1A2,PDK3,ADH4,ALDH1A1,DHRS4,RDH10,ALDH1A3,RARB,PDK4,CYP26B1,RARA,CPT1A,AKR1C3,RXRB,RARG,RDH16,PPARD,DHRS4L1,PDHX,RXRA,RDH11,CYP26A1 R-HSA-3000171|Non-integrin membrane-ECM interactions |0.0235890449586272 |-3.74697287139154|45 |27 |0.00594059405940594 |4545 |10287 |SDC4,FGF2,ITGA2,CASK,NRXN1,LAMB1,NTN4,LAMB3,ITGA6,LAMA5,ACTN1,THBS1,VTN,DMD,SDC1,PRKCA,ITGB1,HSPG2,DDR2,ITGB3,ITGB5,PDGFA,SDC3,DAG1,LAMC1,LAMA3,SDC2 R-HSA-6811438|Intra-Golgi traffic |0.0235890449586272 |-3.74697287139154|45 |27 |0.00594059405940594 |4545 |10287 |VPS45,MAN1C1,GOSR2,NAPG,RAB33B,RIC1,STX16,RAB36,COG7,NAPB,MAN1A2,STX6,CUX1,CYTH1,ARF1,NAPA,CYTH3,ALPP,COG3,MAN2A1,MAN1A1,COG1,COG2,GOLGA5,RAB30,SNAP29,GOSR1 R-HSA-3247509|Chromatin modifying enzymes |0.023902627262616 |-3.73376689878013|279 |140 |0.0308030803080308 |4545 |10287 |NCOA1,HIST1H2BH,HIST1H2BO,USP22,HIST1H4I,SMARCD1,JADE1,EP300,HAT1,HIST1H4H,GATAD2A,TBL1X,KDM4A,RBBP5,HMG20B,NCOA2,SUZ12,KMT2A,KDM2A,EP400,KANSL1,HIST1H2AG,MSL2,ACTL6B,DR1,OGT,EHMT1,MEAF6,EED,NFKB1,ACTB,RUVBL1,HIST2H2AB,TAF12,ELP3,SETDB1,SMARCA2,HIST1H2BL,SUDS3,SETD7,DPY30,SMARCC2,ARID2,SUPT7L,ING5,SAP18,HIST1H4E,ELP4,JMJD6,BRWD1,H2AFV,KAT6A,MTA2,SMARCE1,NSD2,ELP6,KDM4B,ING3,MBIP,ARID1B,ATXN7,ELP5,JADE3,MORF4L1,HIST1H2AK,PRMT6,ARID4B,ARID5B,HIST1H3C,DNMT3A,AEBP2,HIST1H4K,MSL1,RCOR1,H2AFJ,SETDB2,KDM8,BRD1,HIST1H3J,SAP130,PHF20,KMT5A,CARM1,SMYD2,SETD3,MIR7107,SMARCD3,KANSL3,HDAC2,REST,KDM1B,KAT6B,COPRS,PHF8,KDM2B,CCND1,CDK4,HIST1H2BC,NCOR2,KDM6A,SMARCB1,SMARCA4,MTA3,HIST1H2BJ,JADE2,KMT5C,KDM3A,KDM6B,HIST1H2AE,HIST1H4B,RUVBL2,RBBP7,HIST1H2AA,NFKB2,KDM4C,HDAC8,PRMT7,PRDM9,ELP1,PHF21A,WDR77,KAT14,GATAD2B,KDM5B,ASH2L,PRMT3,PBRM1,KAT2B,KMT2B,EPC1,SMARCD2,SMYD3,ATF7IP,H2AFZ,SETD1B,PRMT1,WDR5,CREBBP,JAK2,HIST1H4D R-HSA-4839726|Chromatin organization |0.023902627262616 |-3.73376689878013|279 |140 |0.0308030803080308 |4545 |10287 |SAP130,KMT5A,PHF20,SMYD2,CARM1,MIR7107,SETD3,RCOR1,H2AFJ,HIST1H4K,AEBP2,MSL1,KDM8,SETDB2,HIST1H3J,BRD1,PRMT6,HIST1H2AK,ARID5B,ARID4B,HIST1H3C,DNMT3A,MBIP,ING3,KDM4B,ATXN7,ARID1B,MORF4L1,ELP5,JADE3,KDM6A,SMARCA4,SMARCB1,CCND1,HIST1H2BC,CDK4,NCOR2,PHF8,KDM2B,SMARCD3,KANSL3,KDM1B,COPRS,KAT6B,HDAC2,REST,PHF21A,WDR77,ASH2L,PRMT3,GATAD2B,KAT14,KDM5B,RBBP7,RUVBL2,NFKB2,HIST1H2AA,KDM4C,HDAC8,ELP1,PRDM9,PRMT7,KMT5C,KDM3A,KDM6B,HIST1H4B,HIST1H2AE,MTA3,HIST1H2BJ,JADE2,JAK2,CREBBP,HIST1H4D,SETD1B,H2AFZ,PRMT1,WDR5,SMYD3,ATF7IP,KAT2B,PBRM1,EPC1,KMT2B,SMARCD2,TBL1X,GATAD2A,HIST1H4H,KDM4A,RBBP5,NCOA2,HMG20B,EP300,HAT1,USP22,HIST1H2BO,SMARCD1,HIST1H4I,JADE1,NCOA1,HIST1H2BH,MSL2,HIST1H2AG,ACTL6B,KANSL1,KDM2A,EP400,SUZ12,KMT2A,HIST1H2BL,SMARCA2,SETDB1,SUDS3,DPY30,SETD7,SMARCC2,ARID2,SUPT7L,RUVBL1,HIST2H2AB,TAF12,ELP3,EED,ACTB,NFKB1,EHMT1,OGT,DR1,MEAF6,SMARCE1,NSD2,ELP6,H2AFV,BRWD1,KAT6A,MTA2,JMJD6,ELP4,SAP18,ING5,HIST1H4E R-HSA-15869 |Metabolism of nucleotides |0.0241586448923886 |-3.72311299637977|97 |53 |0.0116611661166117 |4545 |10287 |AK2,LHPP,NT5E,PFAS,UCK2,NUDT5,NT5M,ADSSL1,ADK,GUK1,GMPR2,UCK1,AK5,XDH,RRM2B,CAT,UMPS,GDA,ENTPD5,GLRX,MIR3658,DHODH,TK2,NT5C2,TXN,GSR,IMPDH1,TYMP,ENTPD4,AGXT2,ADSS,ITPA,GPX1,DPYS,PNP,DCTD,DGUOK,APRT,DCTPP1,UPB1,CTPS1,UPP1,NT5C3A,NUDT18,IMPDH2,AK9,UPP2,TXNRD1,PUDP,ENTPD6,GMPR,RRM1,DCK R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation |0.0245617885992823 |-3.70656335265118|93 |51 |0.0112211221122112 |4545 |10287 |TAF4,RBBP8,UBB,MDM4,RPA3,RHNO1,RAD9B,RFC2,RMI2,HIPK2,HIPK1,PRKAA1,PRKAB2,CHEK1,NUAK1,CCNA2,CHEK2,CSNK2A2,TAF3,ATM,BRCA1,PRKAB1,CSNK2B,RPA2,EXO1,CDK5R1,RFC3,BARD1,UBA52,TOPBP1,TAF6,TPX2,TOP3A,CSNK2A1,PLK3,UBC,DNA2,PRKAG2,PRKAG1,TAF1,MAPK14,MDM2,AURKB,TBP,TAF11,NBN,RPA1,ATRIP,TAF12,MIR1257,ATR R-HSA-75153 |Apoptotic execution phase |0.0251188565772 |-3.6841364568417 |53 |31 |0.00682068206820682 |4545 |10287 |FNTA,ACIN1,STK24,HMGB1,GAS2,PRKCD,TJP2,ROCK1,KPNB1,DNM1L,CDH1,DSP,GSN,BCAP31,CTNNB1,ADD1,SPTAN1,PAK2,LMNA,HIST1H1A,LMNB1,HIST1H1C,CASP8,PLEC,DSG1,H1F0,PTK2,BIRC2,KPNA1,DSG2,HMGB2 R-HSA-70326 |Glucose metabolism |0.0255505500876209 |-3.66709643271601|81 |45 |0.0099009900990099 |4545 |10287 |PCK1,PFKP,ALDOA,PKM,UGP2,CALM1,HK2,SLC25A13,PGK2,PGM2,UBC,GOT1,SLC25A12,ALDOB,BPGM,CALM2,PRKACA,PGK1,PCK2,GAPDH,FBP1,SLC25A1,GCK,ADPGK,GYS1,EPM2A,UBB,GYG1,NHLRC1,PYGB,PPP2CA,MDH1,PHKB,PGM1,PPP1R3C,MDH2,PYGL,GYS2,PPP2R1B,GBE1,GPI,PFKL,UBA52,GOT2,SLC25A10 R-HSA-429914 |Deadenylation-dependent mRNA decay |0.0255674575295122 |-3.66643492639775|57 |33 |0.00726072607260726 |4545 |10287 |DCP2,CNOT9,EXOSC3,TNKS1BP1,CNOT11,LSM3,XRN1,CNOT7,LSM2,LSM1,EDC3,EIF4E,CNOT6,DDX6,CNOT2,LSM4,PARN,DCP1A,PABPC1,CNOT1,DCP1B,EXOSC9,CNOT6L,CNOT10,HBS1L,EDC4,DIS3,EIF4A1,CNOT8,EIF4B,PATL1,EIF4A3,WDR61 R-HSA-354192 |Integrin alphaIIb beta3 signaling |0.0255872833625054 |-3.66565979456675|28 |18 |0.00396039603960396 |4545 |10287 |SHC1,VWF,RAPGEF4,CSK,FGG,ITGB3,BCAR1,FGB,SOS1,CRK,SRC,PTPN1,FN1,FGA,PTK2,GRB2,PDPK1,RASGRP2 R-HSA-5656121|Translesion synthesis by POLI |0.0256025490955618 |-3.6650633584084 |17 |12 |0.00264026402640264 |4545 |10287 |RPA3,RPA2,UBB,RFC2,RFC3,PCNA,REV1,RFC1,UBA52,RPA1,POLI,UBC R-HSA-8854518|AURKA Activation by TPX2 |0.0258669316985419 |-3.65478989443592|75 |42 |0.00924092409240924 |4545 |10287 |CEP70,NEDD1,HAUS6,CEP78,PLK1,CEP76,NDE1,PRKACA,TUBB,HMMR,DYNC1H1,NEK2,NINL,CEP250,TPX2,MIR484,YWHAG,CEP192,DCTN2,CEP164,PCM1,CDK5RAP2,ODF2,HAUS3,PLK4,MAPRE1,CKAP5,AKAP9,HSP90AA1,HAUS4,CEP63,CNTRL,PCNT,CETN2,CCP110,DCTN1,CEP72,CLASP1,CSNK1E,CEP152,DYNC1I2,CEP57 R-HSA-1226099|Signaling by FGFR in disease |0.0259354170617799 |-3.65214579026778|63 |36 |0.00792079207920792 |4545 |10287 |GRB2,STAT3,GTF2F2,FGF3,KRAS,GAB2,MYO18A,FRS2,POLR2A,NRAS,FGF1,POLR2E,FGFR4,CUX1,TRIM24,GTF2F1,PIK3R1,FGF20,SOS1,BCR,FGF9,FGF2,FGFR3,FGF10,CNTRL,FGFR1,POLR2D,FGFR2,ERLIN2,CPSF6,STAT5B,BAG4,ZMYM2,LRRFIP1,STAT5A,STAT1 R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer |0.0259898066164654 |-3.65005087104648|65 |37 |0.00814081408140814 |4545 |10287 |KLB,PIK3CB,PIK3R1,FGF20,FGF19,KIT,FGFR3,FGF2,ERBB2,FGF9,PIK3R2,FYN,FGF10,FGFR1,FGFR2,IRS1,PIK3R3,PDGFRB,PIK3AP1,GRB2,FGF3,NRG4,EGF,CD80,BTC,HBEGF,PDGFRA,FRS2,PTPN11,NRG1,ERBB3,CD28,PDGFA,FGF1,KITLG,FGFR4,KL R-HSA-6806834|Signaling by MET |0.02601275346989 |-3.64916834315263|69 |39 |0.00858085808580858 |4545 |10287 |PTPN2,ITGB1,STAM,TNS4,CRKL,LAMA3,LAMC1,RAB4A,UBB,SOS1,PTPRJ,SRC,CRK,UBA52,HGFAC,PTK2,PIK3R1,LAMB3,RANBP10,LAMA5,UBC,SHC1,RAPGEF1,EPS15,RANBP9,TNS3,ARF6,LAMB1,HPN,ITGA2,PTPN1,NRAS,PTPN11,STAT3,GRB2,SH3KBP1,LRIG1,SH3GL1,KRAS R-HSA-2467813|Separation of Sister Chromatids |0.027599904798298 |-3.58994295560201|168 |87 |0.0191419141914191 |4545 |10287 |NDE1,MAD1L1,CENPF,CDC20,PSMA5,CENPC,ANAPC7,TAOK1,AURKB,AHCTF1,KIF2B,UBE2C,UBE2E1,UBC,UBE2D1,CENPU,CENPL,CENPT,SKA1,PSMA7,ANAPC15,PSMB11,KNL1,RPS27,UBA52,BUB3,PPP2R1B,PSMC2,CLASP1,PSMF1,CLASP2,PSMB9,PSMA6,NUDC,PPP2CA,BUB1,DSN1,PSMC4,ANAPC4,CENPA,CLIP1,PSMB5,PSMB10,RCC2,PSMD3,PSMD7,HDAC8,ITGB3BP,PSME4,PSMD14,CENPH,PPP2R5A,PLK1,PDS5A,PSMB4,SEC13,NUP43,NDEL1,SEH1L,PSMB7,PSMD1,RAD21,MIR484,SGO2,PPP1CC,SPC24,PSMA3,CKAP5,CENPS,PSMB8,NSL1,PSMB3,STAG1,ESPL1,SEM1,RANGAP1,RANBP2,MAPRE1,KNTC1,PSMB1,BUB1B,PSMD12,NUP85,PSMA1,XPO1,INCENP,UBB R-HSA-450321 |JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |0.0289527514605536 |-3.542090037664 |19 |13 |0.00286028602860286 |4545 |10287 |IRAK2,UBE2V1,NOD1,IRAK1,RIPK2,NOD2,TAB2,TAB3,UBE2N,IKBKG,MAP2K7,TAB1,MIR718 R-HSA-156580 |Phase II conjugation |0.029066387863998 |-3.53817282861625|106 |57 |0.0125412541254125 |4545 |10287 |OPLAH,AKR1A1,GLYATL3,SLC26A1,SULT1B1,GCLM,MGST1,UGT1A4,ESD,ACSM2A,MAT1A,GSS,UGT2A3,N6AMT1,UGT2B15,SULT1A1,GSTA3,SULT1A2,UGT2B7,GGT5,PAPSS1,GSTO2,SULT1E1,MTRR,SULT2B1,UGT1A5,CHAC1,MAT2A,GGT1,MIR4761,MGST3,GSTP1,MGST2,AHCY,UGT2B4,UGDH,PAPSS2,ACSM1,SULT2A1,UGP2,GSTA1,CNDP2,HPGDS,ABHD10,SLC35D1,MAT2B,GSTO1,GGCT,SULT1C2,ABHD14B,MTR,ACSM2B,GLYATL1,CHAC2,COMT,UGT2B10,GCLC R-HSA-5663213|RHO GTPases Activate WASPs and WAVEs |0.0303692245194355 |-3.49432553467803|36 |22 |0.00484048404840484 |4545 |10287 |ARPC1B,CYFIP1,WASF2,ACTR2,GRB2,WASF1,WASL,PTK2,MAPK1,ARPC5,ABI1,NCK1,ARPC2,ACTR3,ACTG1,CYFIP2,ACTB,CDC42,ABL1,ARPC1A,NCKAP1,ABI2 R-HSA-76009 |Platelet Aggregation (Plug Formation) |0.0312033280980301 |-3.46723052004686|38 |23 |0.00506050605060506 |4545 |10287 |PDPK1,MPL,GRB2,RASGRP2,ADRA2A,CRK,SRC,FGB,SOS1,PTK2,PTPN1,FGA,FN1,FGG,F2,CSK,BCAR1,ITGB3,SHC1,ADRA2C,GP1BA,VWF,RAPGEF4 R-HSA-428157 |Sphingolipid metabolism |0.031674636864983 |-3.45223901724529|90 |49 |0.0107810781078108 |4545 |10287 |SGMS1,GLB1,DEGS1,GM2A,CERK,ARSA,CERS6,ACER2,ALDH3B1,GBA,PLPP3,PLPP1,ARSI,KDSR,ENPP7,ARSB,VAPB,VAPA,PSAP,SPTSSB,SPHK2,DEGS2,SMPD1,ACER1,NEU1,CERS4,CERS2,ASAH2,SUMF2,SGMS2,SPTLC3,CSNK1G2,NEU4,SGPL1,NEU3,SGPP1,ALDH3A2,ESYT3,PPM1L,STS,SPHK1,SPTLC2,ESYT2,ARSG,ACER3,GLTP,FA2H,SPTSSA,HEXB R-HSA-373752 |Netrin-1 signaling |0.0325284332302638 |-3.42564070349744|42 |25 |0.0055005500550055 |4545 |10287 |WASL,ROBO1,PTPN11,FYN,PTK2,HJV,NEO1,NTN4,NCK1,SIAH2,SRC,DCC,ABLIM1,TRPC3,PITPNA,UNC5A,SIAH1,NTN1,DOCK1,TRPC1,UNC5D,ABLIM2,ABLIM3,CDC42,TRIO R-HSA-380284 |Loss of proteins required for interphase microtubule organization from the centrosome |0.0339719316664782 |-3.38222063453236|72 |40 |0.0088008800880088 |4545 |10287 |NEDD1,CEP78,HAUS6,PLK1,CEP70,TUBB,PRKACA,DYNC1H1,NINL,NEK2,NDE1,CEP76,YWHAG,CEP192,DCTN2,CEP250,MIR484,PCM1,CDK5RAP2,CEP164,HAUS3,PLK4,MAPRE1,ODF2,HAUS4,CKAP5,HSP90AA1,AKAP9,DCTN1,CEP72,CEP63,CNTRL,CETN2,PCNT,CCP110,CEP57,CLASP1,CSNK1E,CEP152,DYNC1I2 R-HSA-68949 |Orc1 removal from chromatin |0.0339719316664782 |-3.38222063453236|72 |40 |0.0088008800880088 |4545 |10287 |PSMF1,PSMB9,PSMA6,CCNA2,ORC2,PSMD12,PSMC4,ORC4,PSMA1,UBB,PSMB5,ORC1,UBA52,ORC5,CDT1,PSMB8,PSMB3,CDKN1A,PSMC2,SEM1,CDC6,PSMB1,PSMB4,UBC,PSMB7,ORC6,PSMA7,PSMD1,PSMB11,PSMA3,MCM5,PSMD3,PSMB10,PSMD7,MCM3,PSME4,PSMA5,PSMD14,MCM4,FZR1 R-HSA-380259 |Loss of Nlp from mitotic centrosomes |0.0339719316664782 |-3.38222063453236|72 |40 |0.0088008800880088 |4545 |10287 |ODF2,PLK4,HAUS3,MAPRE1,CKAP5,AKAP9,HSP90AA1,HAUS4,CNTRL,CEP63,CCP110,CETN2,PCNT,DCTN1,CEP72,CLASP1,DYNC1I2,CSNK1E,CEP152,CEP57,CEP70,NEDD1,PLK1,CEP78,HAUS6,CEP76,NDE1,PRKACA,TUBB,NINL,DYNC1H1,NEK2,MIR484,CEP250,CEP192,DCTN2,YWHAG,CEP164,CDK5RAP2,PCM1 R-HSA-69052 |Switching of origins to a post-replicative state |0.0339719316664782 |-3.38222063453236|72 |40 |0.0088008800880088 |4545 |10287 |FZR1,MCM4,PSMD14,PSMA5,PSME4,MCM3,PSMD7,PSMD3,PSMB10,MCM5,PSMA3,PSMB11,PSMD1,PSMA7,ORC6,PSMB7,UBC,PSMB4,CDC6,PSMB1,SEM1,PSMC2,CDKN1A,PSMB3,PSMB8,CDT1,ORC5,UBA52,ORC1,PSMB5,UBB,PSMA1,ORC4,PSMC4,PSMD12,ORC2,CCNA2,PSMA6,PSMB9,PSMF1 R-HSA-211897 |Cytochrome P450 - arranged by substrate type |0.0342973546362853 |-3.37268705209102|68 |38 |0.00836083608360836 |4545 |10287 |CYP2J2,CYP1A1,CYP2C18,CYP26A1,CYP24A1,RXRA,CYP2S1,CYP26B1,CYP19A1,NR1H4,CYP2W1,CYP4F12,CYP2A6,CYP2B6,CYP11B2,FDX1,CYP2R1,CYP3A4,CYP2C8,CYP4F3,FDXR,CYP3A7-CYP3A51P,POR,CYP2C9,POMC,NCOA1,AHR,CYP51A1,CYP8B1,CYP27B1,CYP3A43,TBXAS1,PTGIS,NCOA2,ARNT,CYP26C1,MIR4651,CYP27A1 R-HSA-216083 |Integrin cell surface interactions |0.0342973546362853 |-3.37268705209102|68 |38 |0.00836083608360836 |4545 |10287 |ITGAD,PECAM1,ITGAL,COL16A1,FN1,FGA,ICAM3,FGB,ITGA1,FBN1,ITGB3,COL9A2,DAG1,COL4A4,COMP,ICAM2,ITGB1,ITGAX,ITGA6,THBS1,VTN,SPP1,ITGA2,COL9A3,ITGB2,BSG,ICAM1,ITGAE,ITGB5,ITGA7,LINC02478,FGG,ICAM4,F11R,COL23A1,HSPG2,CDH1,ITGAM R-HSA-2173795|Downregulation of SMAD2/3:SMAD4 transcriptional activity |0.0343948752327441 |-3.3698477014931 |23 |15 |0.0033003300330033 |4545 |10287 |UBC,SMURF2,SMAD4,UBA52,SMAD3,UBE2D1,TGIF1,NCOR2,USP9X,PARP1,TRIM33,SKI,NEDD4L,UBE2D3,UBB R-HSA-5654693|FRS-mediated FGFR1 signaling |0.0343948752327441 |-3.3698477014931 |23 |15 |0.0033003300330033 |4545 |10287 |KRAS,FGF20,FGFR1,FGF3,GRB2,FGF10,PTPN11,NRAS,FGF9,FRS2,KL,FGF2,FRS3,FGF1,SOS1 R-HSA-5365859|RA biosynthesis pathway |0.0343948752327441 |-3.3698477014931 |23 |15 |0.0033003300330033 |4545 |10287 |ALDH1A1,DHRS4L1,DHRS4,RDH11,CYP26A1,ALDH1A2,RDH16,ADH4,AKR1C3,CYP26C1,DHRS3,RDH10,ALDH1A3,ALDH8A1,CYP26B1 R-HSA-3371571|HSF1-dependent transactivation |0.0343948752327441 |-3.3698477014931 |23 |15 |0.0033003300330033 |4545 |10287 |RPTOR,CAMK2A,EP300,MTOR,DNAJB1,HSPA8,HSP90AA1,CREBBP,CAMK2B,CAMK2G,AKT1S1,HSPA1B,HSP90AB1,HSPA1A,CAMK2D R-HSA-112409 |RAF-independent MAPK1/3 activation |0.0343948752327441 |-3.3698477014931 |23 |15 |0.0033003300330033 |4545 |10287 |DUSP1,PTPN11,IL6ST,MAPK1,DUSP7,JAK1,IL6R,DUSP9,MAP2K1,JAK2,DUSP5,TYK2,DUSP10,DUSP6,DUSP16 R-HSA-174113 |SCF-beta-TrCP mediated degradation of Emi1 |0.0345515244524816 |-3.3653036066599 |56 |32 |0.00704070407040704 |4545 |10287 |PSMC4,PSMD12,PSMA1,UBB,PSMB5,PSMB9,PSMF1,PSMA6,PSMB8,PSMB3,SEM1,PSMC2,PSMB1,UBA52,BTRC,SKP1,PSMA7,PSMD1,PSMB11,PSMA3,CUL1,PSMB4,UBC,PSMB7,PSMD14,FZR1,PSMD3,PSMB10,PSMD7,CDC20,PSME4,PSMA5 R-HSA-69541 |Stabilization of p53 |0.0345515244524816 |-3.3653036066599 |56 |32 |0.00704070407040704 |4545 |10287 |PSMF1,PSMB9,CHEK2,PSMA6,PSMA1,PSMC4,PSMD12,UBB,PSMB5,MDM4,UBA52,COP1,ATM,PSMB8,PSMB3,PSMB1,SEM1,PSMC2,PSMB4,UBC,PSMB7,PSMD1,PSMA7,PSMA3,PSMB11,PSMB10,PSMD3,PSMD7,PSME4,PSMA5,MDM2,PSMD14 R-HSA-69306 |DNA Replication |0.0354475357940111 |-3.33970154057774|109 |58 |0.0127612761276128 |4545 |10287 |MCM4,PRIM2,FZR1,PSMD14,PSMD3,PSMB10,PSMD7,MCM10,MCM5,RPA1,PSME4,PSMA5,E2F2,MCM3,POLD2,PSMD1,PSMA7,PSMA3,PSMB11,PSMB4,UBC,DNA2,PSMB7,ORC6,CDC7,GMNN,CDKN1A,PSMB8,PSMB3,CDC6,RPA2,PSMB1,PSMC2,RFC3,SEM1,UBA52,POLE4,ORC1,ORC5,CDT1,PSMA1,E2F3,PSMC4,PSMD12,ORC4,UBB,PSMB5,RPA3,PCNA,RFC2,RFC1,POLE3,PSMB9,PSMF1,CCNA2,ORC2,GINS1,PSMA6 R-HSA-202733 |Cell surface interactions at the vascular wall |0.035538080804123 |-3.33715045872322|136 |71 |0.0156215621562156 |4545 |10287 |GRB14,SLC7A7,ITGB1,SLC16A3,PICK1,FYN,FN1,PIK3R2,TREM1,SRC,GLG1,SOS1,SLC3A2,SELPLG,TSPAN7,MAG,PECAM1,ITGAL,VPREB1,F11R,ITGAM,SHC1,INPP5D,JAML,TEK,PROS1,SLC7A9,ATP1B1,SDC3,NRAS,SDC4,SELE,BSG,ITGB2,GPC1,KRAS,CD99,GRB2,LYN,ITGB3,MIF,GRB7,SLC7A10,PPIA,CEACAM8,PROC,ATP1B3,ANGPT4,APOB,YES1,SLC7A6,SLC7A8,GYPC,SLC7A5,PIK3R1,PIK3CB,SDC1,MERTK,CD99L2,SDC2,TNFRSF10D,SIRPA,F2,PTPN11,CXADR,MIR6787,TNFRSF10B,ITGAX,ITGA6,CAV1,SLC7A11 R-HSA-382556 |ABC-family proteins mediated transport |0.0359249056159685 |-3.32632447427259|107 |57 |0.0125412541254125 |4545 |10287 |APOA1,RNF185,RNASEL,PSMA5,ABCG5,PSME4,ABCA9,DERL1,PSMD7,PSMD3,PSMB10,ERLIN1,PEX19,ABCC1,ABCA8,ABCC2,ABCC8,PSMD14,ABCA4,PSMB7,SEL1L,ABCD1,ABCD3,EIF2S3,PEX3,UBC,OS9,PSMB4,PSMA3,ABCA10,PSMB11,PSMD1,PSMA7,ABCC3,ABCC10,UBA52,PSMB1,SEM1,PSMC2,PSMB3,PSMB8,ABCC6,ERLEC1,PSMA6,PSMF1,EIF2S2,PSMB9,ERLIN2,ABCG8,PSMB5,UBB,ABCB4,ABCC11,PSMA1,ABCC4,PSMC4,PSMD12 R-HSA-982772 |Growth hormone receptor signaling |0.0365680519908687 |-3.3085803161951 |25 |16 |0.00352035203520352 |4545 |10287 |CISH,SOCS1,STAT5A,PRLR,STAT1,IRS1,SOCS3,STAT5B,LYN,GHR,PTPN1,MAPK1,SOCS2,JAK2,STAT3,ADAM17 R-HSA-429947 |Deadenylation of mRNA |0.0365680519908687 |-3.3085803161951 |25 |16 |0.00352035203520352 |4545 |10287 |PABPC1,CNOT11,CNOT1,CNOT7,CNOT9,PARN,CNOT2,TNKS1BP1,EIF4E,CNOT6,EIF4B,CNOT8,EIF4A1,EIF4A3,CNOT6L,CNOT10 R-HSA-162588 |Budding and maturation of HIV virion |0.0365680519908687 |-3.3085803161951 |25 |16 |0.00352035203520352 |4545 |10287 |VPS4A,CHMP4A,CHMP6,CHMP2B,CHMP2A,UBA52,PDCD6IP,PPIA,VPS37B,NEDD4L,CHMP4B,UBB,CHMP4C,VPS4B,UBC,CHMP3 R-HSA-2187338|Visual phototransduction |0.0373635957188683 |-3.28705842510104|101 |54 |0.0118811881188119 |4545 |10287 |AKR1C1,SDC4,LDLR,GPC5,APOA1,NMT1,STRA6,GPC1,LRP2,GPC3,MYO7A,DHRS3,APOA2,CALM2,CAMKMT,APOC3,SDC1,APOM,RDH11,LRP8,GPC4,ABCA4,PRKCA,APOC2,RGS9,RDH16,RBP4,HSPG2,GNB5,OPN1LW,RHO,RDH10,SDC3,CALM1,APOA4,FNTA,SDC2,CNGB1,LRP1,GUCY2D,APOB,GUCA1B,HSD17B6,OPN1SW,FNTB,MIR6886,PLB1,RDH12,GNAT1,GPC6,AKR1C3,RLBP1,SDR9C7,HSD17B1 R-HSA-193704 |p75 NTR receptor-mediated signalling |0.0383232573201802 |-3.26169832635581|97 |52 |0.0114411441144114 |4545 |10287 |PLEKHG2,UBB,ABR,KALRN,ITSN1,ARHGEF1,ARHGEF2,AKAP13,VAV2,HDAC2,MIR7706,VAV3,MAG,ADAM17,FGD4,IRAK1,ARHGEF4,ARHGDIA,UBA52,OMG,ARHGEF10L,AATF,SOS1,FGD2,RTN4,ARHGEF26,TRIO,RHOA,ARHGEF7,TIAM2,BCL2L11,ARHGEF3,OBSCN,NGEF,ARHGEF16,NET1,NFKB1,NFKBIA,MIR718,RASGRF2,ARHGEF12,UBC,ARHGEF6,ARHGEF19,NCSTN,SQSTM1,MCF2L,PREX1,RIPK2,PRKCI,ITGB3BP,ARHGEF10 R-HSA-2173788|Downregulation of TGF-beta receptor signaling |0.0384294015015713 |-3.25893244825626|27 |17 |0.00374037403740374 |4545 |10287 |SMURF2,UBA52,PPP1R15A,PPP1CB,TGFBR2,PMEPA1,UBC,SMAD7,SMAD3,NEDD4L,MTMR4,USP15,SMURF1,XPO1,PPP1CC,UBB,STRAP R-HSA-418360 |Platelet calcium homeostasis |0.0413579169104023 |-3.18549141488585|31 |19 |0.00418041804180418 |4545 |10287 |ITPR1,ATP2B3,CALM2,ATP2B4,ITPR2,TRPC3,SLC8A3,ATP2A2,MIR4687,ORAI1,P2RX4,P2RX3,ATP2A1,CALM1,P2RX7,ATP2B1,ATP2B2,ITPR3,SRI R-HSA-68882 |Mitotic Anaphase |0.0419037946721964 |-3.17237889118592|179 |91 |0.02002200220022 |4545 |10287 |SGO2,MIR484,RAD21,PSMD1,PSMA3,SPC24,PPP1CC,NUP43,SEC13,PSMB4,PSMB7,SEH1L,NDEL1,CENPH,PSMD14,PLK1,PDS5A,PPP2R5A,PSMD7,PSMD3,PSMB10,RCC2,PSME4,ITGB3BP,HDAC8,PSMA1,NUP85,PSMD12,UBB,INCENP,XPO1,BUB1B,ESPL1,STAG1,NSL1,PSMB3,PSMB8,PSMB1,KNTC1,MAPRE1,RANBP2,RANGAP1,SEM1,CKAP5,CENPS,ANAPC15,PSMA7,SKA1,KNL1,RPS27,PSMB11,UBC,CENPT,CENPL,UBE2D1,CENPU,AURKB,AHCTF1,TAOK1,CENPC,ANAPC7,UBE2E1,UBE2C,KIF2B,MAD1L1,CENPF,NDE1,PSMA5,CDC20,CENPA,ANAPC4,PSMC4,PSMB5,CLIP1,CLASP2,PSMB9,PSMF1,CLASP1,DSN1,BUB1,PPP2CA,NUDC,PSMA6,LMNA,VRK1,LMNB1,PSMC2,PPP2R2A,UBA52,PPP2R1B,BUB3 R-HSA-5686938|Regulation of TLR by endogenous ligand |0.0421212623238539 |-3.16720262246331|16 |11 |0.00242024202420242 |4545 |10287 |FGA,TLR6,FGB,APOB,LBP,CD36,HMGB1,S100A9,CD14,LY96,FGG R-HSA-110312 |Translesion synthesis by REV1 |0.0421212623238539 |-3.16720262246331|16 |11 |0.00242024202420242 |4545 |10287 |UBA52,RFC1,UBC,RPA1,REV1,UBB,RPA3,RPA2,PCNA,RFC3,RFC2 R-HSA-5684264|MAP3K8 (TPL2)-dependent MAPK1/3 activation |0.0421212623238539 |-3.16720262246331|16 |11 |0.00242024202420242 |4545 |10287 |IKBKG,MAP2K1,UBB,FBXW11,NFKB1,CUL1,UBC,UBA52,SKP1,BTRC,MAP3K8 R-HSA-1483255|PI Metabolism |0.0424787625421954 |-3.15875103283538|79 |43 |0.00946094609460946 |4545 |10287 |PI4KA,INPP5D,GDPD5,RUFY1,MTM1,PLEKHA2,OCRL,PIK3C2G,TNFAIP8L3,TNFAIP8L1,VAC14,PIP5K1B,TNFAIP8,MTMR7,PIK3R5,MTMR4,PITPNB,RAB4A,ARF1,PIK3R3,RAB14,SYNJ2,GDPD1,PIKFYVE,PIP4P1,PIP5K1A,ENPP6,PI4K2A,PIP4K2A,PIK3R1,PIK3CB,PNPLA7,MTMR14,PLEKHA6,PI4KB,INPP4A,MTMR2,MTMR3,PIK3C2B,PIK3C3,PIK3C2A,PIK3R2,PIK3CG R-HSA-5357905|Regulation of TNFR1 signaling |0.0424863395804971 |-3.15857267635413|33 |20 |0.0044004400440044 |4545 |10287 |SPPL2A,TRAF2,USP4,TRAF1,UBC,RIPK1,RBCK1,UBB,OTUD7B,IKBKG,TAX1BP1,BIRC3,XIAP,TNFRSF1A,BIRC2,SPPL2B,UBA52,CLIP3,CASP8,USP2 R-HSA-2262749|Cellular response to hypoxia |0.0429030344886992 |-3.14881272154738|77 |42 |0.00924092409240924 |4545 |10287 |VEGFA,UBA52,PSMB8,PSMB3,ELOC,PSMC2,SEM1,CREBBP,PSMB1,EPAS1,PSMF1,PSMB9,PSMA6,HIF1A,CITED2,PSMC4,PSMD12,PSMA1,UBB,PSMB5,EGLN3,EP300,PSMD3,PSMB10,PSMD7,PSME4,PSMA5,PSMD14,CUL2,LIMD1,EGLN2,ARNT,PSMB4,UBC,VHL,UBE2D1,PSMB7,PSMA7,PSMD1,PSMB11,UBE2D3,PSMA3 R-HSA-1234174|Regulation of Hypoxia-inducible Factor (HIF) by oxygen |0.0429030344886992 |-3.14881272154738|77 |42 |0.00924092409240924 |4545 |10287 |EGLN3,EP300,PSMB10,PSMD3,PSMD7,PSME4,PSMA5,PSMD14,LIMD1,CUL2,EGLN2,ARNT,PSMB4,UBC,VHL,UBE2D1,PSMB7,PSMD1,PSMA7,PSMB11,UBE2D3,PSMA3,VEGFA,UBA52,PSMB8,PSMB3,ELOC,SEM1,PSMC2,CREBBP,PSMB1,EPAS1,PSMB9,PSMF1,PSMA6,HIF1A,CITED2,PSMC4,PSMD12,PSMA1,UBB,PSMB5 R-HSA-170834 |Signaling by TGF-beta Receptor Complex |0.0429030344886992 |-3.14881272154738|77 |42 |0.00924092409240924 |4545 |10287 |JUNB,PARD3,E2F5,PPP1R15A,TGIF1,USP15,SMURF1,RHOA,UBE2D3,PPP1CC,WWTR1,SMAD7,SMAD3,CGN,UBC,PARP1,FURIN,F11R,UBE2D1,SKI,TGFBR2,PPP1CB,PMEPA1,MIR6869,TFDP2,UBA52,SMAD4,SMURF2,NCOR2,SERPINE1,PRKCZ,RBL1,MTMR4,TRIM33,NEDD4L,STRAP,UBB,CCNT2,CDK8,CDKN2B,XPO1,USP9X R-HSA-425366 |Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |0.0446214266778789 |-3.10954111653375|106 |56 |0.0123212321232123 |4545 |10287 |RHBG,SLC44A1,SLC11A1,SLC16A7,SLC5A9,RUNX1,SLC16A3,SLC30A2,SLC39A14,SLC13A3,SLC39A10,SLC2A14,SLC6A11,SLC2A11,SLC5A11,SLC40A1,SLC6A6,SLC2A9,SLC2A10,SLC31A1,SLC13A5,SLC22A2,SLC6A1,SLC6A5,SLC41A2,SLC44A5,SLC6A7,SLC30A5,SLC47A1,SLC6A12,SLC6A2,MFSD4B,SLC2A2,SLC2A8,SLC22A8,SLC13A2,SLC13A1,SLC22A18,SLC22A3,SLC11A2,CP,SLC2A4,SLC22A7,SLC22A11,SLC30A1,SLC47A2,LOC100506403,SLC6A14,BSG,MIR6787,SLC14A2,SLC22A16,SLC30A6,SLC2A5,FGF21,SLC2A1 R-HSA-1234176|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |0.0447920728286748 |-3.10572410100646|67 |37 |0.00814081408140814 |4545 |10287 |PSME4,PSMA5,PSMB10,PSMD3,PSMD7,EGLN3,EGLN2,PSMD14,CUL2,LIMD1,PSMB7,UBE2D1,PSMB4,VHL,UBC,PSMA3,PSMB11,UBE2D3,PSMD1,PSMA7,UBA52,PSMB1,SEM1,PSMC2,ELOC,PSMB8,PSMB3,HIF1A,PSMA6,EPAS1,PSMB9,PSMF1,UBB,PSMB5,PSMA1,PSMD12,PSMC4 R-HSA-1632852|Macroautophagy |0.0447920728286748 |-3.10572410100646|67 |37 |0.00814081408140814 |4545 |10287 |MTOR,PRKAB2,PRKAA1,WIPI1,ATG5,ATG14,ATG13,MAP1LC3A,UVRAG,MTMR3,PIK3C3,PRKAB1,LAMTOR4,CHMP2A,MTMR14,CHMP6,RHEB,CHMP3,CHMP4C,TSC2,ATG7,PRKAG1,AMBRA1,PRKAG2,CHMP4B,GABARAPL2,ATG4C,ATG10,RRAGB,ATG16L1,RPTOR,RRAGC,GABARAPL1,CHMP4A,MAP1LC3B,CHMP2B,ATG4B R-HSA-5358346|Hedgehog ligand biogenesis |0.0447920728286748 |-3.10572410100646|67 |37 |0.00814081408140814 |4545 |10287 |ADAM17,PSMB3,PSMB8,PSMB1,SEM1,PSMC2,UBA52,SYVN1,PSMA1,PSMC4,PSMD12,PSMB5,UBB,PSMB9,PSMF1,ERLEC1,PSMA6,SHH,HHAT,PSMD14,PSMD7,PSMB10,PSMD3,IHH,PSMA5,PSME4,GPC5,PSMD1,PSMA7,PSMA3,PSMB11,P4HB,UBC,PSMB4,OS9,PSMB7,SEL1L R-HSA-5654743|Signaling by FGFR4 |0.0453185468820673 |-3.09403890683886|41 |24 |0.00528052805280528 |4545 |10287 |UBB,FGFR4,FRS3,SHC1,SPRY2,UBC,FGF1,PPP2CA,PIK3R1,GRB2,KLB,KRAS,FGF19,FGF20,UBA52,SRC,SOS1,MAPK1,PTPN11,BRAF,NRAS,FRS2,FGF9,FGF2 R-HSA-1236394|Signaling by ERBB4 |0.0456980680682728 |-3.08569925619278|43 |25 |0.0055005500550055 |4545 |10287 |NRAS,WWOX,UBA52,HBEGF,BTC,ITCH,SOS1,KRAS,PIK3R1,EGF,NRG4,GRB2,ADAM17,STAT5A,NCSTN,ESR1,SHC1,UBC,UBB,NEDD4,YAP1,TAB2,WWP1,ERBB3,NRG1 R-HSA-75893 |TNF signaling |0.0456980680682728 |-3.08569925619278|43 |25 |0.0055005500550055 |4545 |10287 |BAG4,UBC,TRAF1,USP4,TRAF2,TAB1,SPPL2A,TAX1BP1,IKBKG,OTUD7B,TAB2,UBB,RBCK1,RIPK1,CASP8,UBA52,SPPL2B,CLIP3,TNFRSF1A,BIRC2,XIAP,BIRC3,TAB3,ADAM17,USP2 R-HSA-194068 |Bile acid and bile salt metabolism |0.0456980680682728 |-3.08569925619278|43 |25 |0.0055005500550055 |4545 |10287 |SCP2,AMACR,AKR1C1,ABCC3,CYP8B1,OSBPL9,AKR1C2,BAAT,PTGIS,SLCO1B3,NCOA2,OSBPL2,HSD17B4,CYP27A1,AKR1D1,NCOA1,RXRA,OSBPL6,OSBPL3,SLC27A2,NR1H4,ALB,SLC27A5,ACOX2,AKR1C3 R-HSA-450408 |AUF1 (hnRNP D0) binds and destabilizes mRNA |0.0460511301140679 |-3.07800297555984|57 |32 |0.00704070407040704 |4545 |10287 |PSMA5,PSME4,PSMD7,HSPA8,PSMB10,PSMD3,PSMD14,HSPA1A,PSMB7,UBC,PSMB4,PABPC1,PSMB11,PSMA3,PSMD1,PSMA7,HSPB1,UBA52,PSMC2,SEM1,PSMB1,PSMB3,PSMB8,PSMA6,HNRNPD,PSMF1,PSMB9,PSMB5,UBB,PSMC4,PSMD12,PSMA1 R-HSA-912631 |Regulation of signaling by CBL |0.0462651485483239 |-3.07336633247199|18 |12 |0.00264026402640264 |4545 |10287 |FYN,PIK3R2,CRK,YES1,PIK3R3,RAPGEF1,LYN,BLNK,PIK3R1,PIK3CB,GRB2,CRKL R-HSA-71406 |Pyruvate metabolism and Citric Acid (TCA) cycle |0.0462677935600589 |-3.07330916338873|49 |28 |0.00616061606160616 |4545 |10287 |SDHB,SUCLG2,LDHAL6B,BSG,MIR6787,PDP1,PDK3,GLO1,ACO2,PDP2,MDH2,SUCLG1,PDK1,CS,LDHA,IDH2,RXRA,PDHX,D2HGDH,PPARD,PDPR,OGDH,HAGH,DLST,SLC16A3,PDK4,IDH3A,MPC1 R-HSA-69278 |Cell Cycle, Mitotic |0.0469957052752221 |-3.05769905857016|514 |246 |0.0541254125412541 |4545 |10287 |ODF2,SET,LMNA,RAE1,RFC3,PLK4,HSP90AA1,PPP2R2A,TFDP2,POLE4,MYBL2,ENSA,PPP2R1B,PCNT,LPIN1,CEP72,NUP205,MCPH1,PSMB5,RPA3,PCNA,CDKN2B,CEP152,DYNC1I2,CLASP1,ORC2,GINS1,CDC25B,NUDC,NUP35,AHCTF1,AURKB,ANAPC7,CENPC,HIST1H4H,NUP214,NEDD1,KIF2B,UBE2C,CNEP1R1,NUP42,MCM10,E2F5,NDE1,EP300,CDC20,HIST1H4I,ANAPC15,HIST1H2BO,YWHAG,KNL1,PSMB11,NUP58,CSNK2A1,CEP164,UBC,LIN37,DNA2,CENPL,ORC6,RBL2,CDC7,CENPU,PCM1,HIST1H2BH,ESPL1,STAG1,PSMB8,NSL1,MAPRE1,CDC6,HAUS3,RANBP2,RANGAP1,CDKN2D,DHFR,H2AFV,CKAP5,MAPK1,NUP188,NUP210,ORC5,CENPS,RBL1,BTRC,CCP110,PSMA1,CEP63,MASTL,PPP1R12B,UBB,TK2,DCTN1,LIN54,INCENP,CCND3,BUB1B,HIST1H4E,CSNK2A2,CENPH,HIST1H2BL,GORASP2,CEP78,PPP2R5A,RCC2,PSMD3,PSMD7,CEP76,RPA1,MCM5,PSME4,DYNC1H1,NINL,NEK2,LPIN2,HMMR,PRKACA,TUBB,RAD21,SGO2,POLD2,NUP93,USO1,CEP192,DCTN2,PSMB4,CUL1,NCAPH2,NCAPD2,SEH1L,CDKN1A,PPP1CB,VRK1,PHLDA1,LMNB1,RPA2,PSMC2,HIST1H2BC,UBA52,CDK4,CCND1,NEK6,HAUS4,BUB3,CETN2,E2F3,PHF8,PSMC4,ANAPC4,CENPA,CLIP1,FBXW11,RFC2,RAB2A,DYRK1A,RFC1,CSNK1E,PSMB9,PSMF1,CLASP2,CEP57,BUB1,CCNA2,DSN1,PSMA6,PPP2CA,MCM4,KMT5A,FZR1,TAOK1,SKP2,HAUS6,UBE2E1,MAD1L1,CENPF,H2AFJ,HIST1H4K,HIST1H3J,PSMA5,NUMA1,E2F2,TPX2,SKA1,PSMA7,LIN52,TUBGCP5,RPS27,LPIN3,HIST1H3C,CENPT,PRKCA,UBE2D1,RAB1A,CDK6,GMNN,PSMB3,HIST1H4D,CSNK2B,PSMB1,KNTC1,SEM1,AKAP9,H2AFZ,ORC1,PPP2R2D,SKP1,CDT1,CCNH,PSMD12,ORC4,CNTRL,NUP85,XPO1,ESCO1,MIR4738,POLE3,PRIM2,CEP70,PSMD14,PLK1,PDS5A,AKT3,BORA,PSMB10,KIF20A,ITGB3BP,MCM3,HDAC8,CEP250,MIR484,HSP90AB1,PSMD1,HIST1H4B,PSMA3,HIST1H2AE,SPC24,PPP2R3B,PPP1CC,HIST1H2BJ,NUP43,SEC13,CCNE1,PSMB7,WEE1,NDEL1,CDK5RAP2 R-HSA-199418 |Negative regulation of the PI3K/AKT network |0.0486266024624674 |-3.02358452206023|94 |50 |0.011001100110011 |4545 |10287 |KIT,SRC,MAPK1,FYN,ERBB2,PIK3R2,FGF9,PPP2R1B,FGFR3,FGF2,PIK3R1,PIP4K2A,PHLPP2,PIK3CB,KLB,FGF19,FGF20,PIK3R3,IRS1,PIK3AP1,PIP5K1A,PPP2CA,PDGFRB,FGFR1,FGF10,FGFR2,BTC,HBEGF,CD80,PTPN11,FRS2,PDGFRA,NRG4,FGF3,EGF,INSR,GRB2,PIP5K1B,AKT3,PPP2R5A,FGFR4,PHLPP1,KITLG,FGF1,TRIB3,KL,ERBB3,NRG1,PDGFA,CD28 R-HSA-2555396|Mitotic Metaphase and Anaphase |0.0486768764028142 |-3.02255117884564|180 |91 |0.02002200220022 |4545 |10287 |INCENP,XPO1,UBB,NUP85,PSMD12,PSMA1,BUB1B,RANBP2,RANGAP1,SEM1,KNTC1,PSMB1,MAPRE1,PSMB3,NSL1,PSMB8,STAG1,ESPL1,CENPS,CKAP5,PPP1CC,PSMA3,SPC24,PSMD1,MIR484,SGO2,RAD21,NDEL1,PSMB7,SEH1L,SEC13,PSMB4,NUP43,PPP2R5A,PLK1,PDS5A,PSMD14,CENPH,HDAC8,ITGB3BP,PSME4,PSMD7,PSMB10,RCC2,PSMD3,PSMB5,CLIP1,CENPA,ANAPC4,PSMC4,PPP2CA,PSMA6,NUDC,DSN1,BUB1,CLASP1,CLASP2,PSMF1,PSMB9,PSMC2,LMNB1,VRK1,LMNA,PPP2R1B,BUB3,UBA52,PPP2R2A,PSMB11,KNL1,RPS27,PSMA7,ANAPC15,SKA1,UBE2D1,CENPU,CENPT,CENPL,UBC,UBE2C,KIF2B,UBE2E1,TAOK1,CENPC,ANAPC7,AURKB,AHCTF1,CDC20,PSMA5,NDE1,CENPF,MAD1L1 R-HSA-6804760|Regulation of TP53 Activity through Methylation |0.0496977125606663 |-3.00179637187503|20 |13 |0.00286028602860286 |4545 |10287 |MDM4,UBB,SMYD2,ATM,MDM2,KMT5A,SETD9,CHEK2,EHMT1,UBA52,EP300,UBC,JMY R-HSA-194223 |HDL-mediated lipid transport |0.0496977125606663 |-3.00179637187503|20 |13 |0.00286028602860286 |4545 |10287 |ALB,AMN,CETP,HDLBP,LCAT,APOC3,SCARB1,PRKACA,A2M,ABCA1,APOA1,APOC2,PLTP R-HSA-446728 |Cell junction organization |0.0506713384413439 |-2.98239484497553|88 |47 |0.0103410341034103 |4545 |10287 |CDH1,CDH5,F11R,ARHGEF6,CTNNB1,CADM1,FERMT2,PXN,CTNNA1,CLDN12,CLDN7,PLEC,PARD3,LIMS2,CDH4,TESK1,PRKCI,ANG,CDH11,CDH18,NECTIN4,CLDN19,DST,ITGA6,AFDN,ITGB1,CDH2,PARD6G,CADM2,RSU1,CLDN4,PARD6B,LAMA3,FBLIM1,MPP5,CLDN14,CDH12,CDH17,CDH6,JUP,CDH10,CLDN23,CLDN1,LAMB3,PATJ,CLDN22,ACTN1 R-HSA-163685 |Integration of energy metabolism |0.0524668450684216 |-2.94757383138515|111 |58 |0.0127612761276128 |4545 |10287 |KCNS3,PLCB1,GNG10,ADCY7,ABCC8,ITPR1,AGPAT1,MLXIPL,ACLY,GNB4,PRKACA,SLC2A1,ADIPOR1,STX1A,GNG4,CACNA1D,AHCYL1,GNB5,SLC2A2,ARL2BP,CACNA1E,GNAI1,TALDO1,GNA14,PRKCA,PRKAG2,CACNA1A,ADCY3,ADCY1,ITPR2,ACACA,ADCY4,GNAS,IQGAP1,ADCY8,KCNB1,PPP2R1B,KCNG2,PRKAR1A,STXBP1,GNGT2,ADRA2A,SLC25A4,ADCY9,VAMP2,FASN,CACNB3,GNAI2,GNG7,PPP2CA,MLX,RAPGEF4,ADIPOR2,GCGR,ADRA2C,ACACB,PRKAB2,ITPR3 R-HSA-901032 |ER Quality Control Compartment (ERQC) |0.0525291610904254 |-2.94638681424801|22 |14 |0.00308030803080308 |4545 |10287 |RNF139,UGGT1,UBB,AMFR,EDEM2,MARCH6,UBA52,OS9,EDEM1,RNF103,UBC,SEL1L,RNF185,SYVN1 R-HSA-5621575|CD209 (DC-SIGN) signaling |0.0525291610904254 |-2.94638681424801|22 |14 |0.00308030803080308 |4545 |10287 |PRKACA,ICAM3,FYN,NRAS,ICAM2,EP300,RAF1,CREBBP,KRAS,PAK1,LYN,NFKB1,PAK3,PAK2 R-HSA-5654712|FRS-mediated FGFR4 signaling |0.0525291610904254 |-2.94638681424801|22 |14 |0.00308030803080308 |4545 |10287 |GRB2,KLB,FGF20,FGF19,KRAS,FRS3,SOS1,FGF1,FGFR4,FRS2,FGF9,FGF2,PTPN11,NRAS R-HSA-425393 |Transport of inorganic cations/anions and amino acids/oligopeptides |0.0541705478431307 |-2.9156179159588 |107 |56 |0.0123212321232123 |4545 |10287 |SLC38A2,SLC7A8,SLC7A6,SLC25A26,SLC9A8,SLC8A3,SLC6A6,SLC9A1,SLC5A12,SLC1A7,SLC7A5,SLC7A10,SLC26A3,CTNS,SLC1A5,SLC3A2,SLC38A1,SLC38A5,SLC25A10,SLC12A7,SLC36A2,SLC4A7,SLC25A18,SLC4A5,SLC34A2,SLC43A1,SLC7A7,SRI,SLC15A2,SLC17A8,SLC20A2,SLC7A1,SLC26A1,SLC43A2,SLC6A14,SLC7A2,SLC3A1,CALM2,SLC7A11,SLC15A1,SLC1A3,SLC4A10,SLC24A4,SLC26A7,SLC17A5,SLC38A4,AHCYL2,SLC7A9,SLC6A12,SLC4A3,SLC20A1,CALM1,SLC1A2,SLC5A5,SLC38A3,SLC1A4 R-HSA-1169408|ISG15 antiviral mechanism |0.0547387594108291 |-2.90518323892877|76 |41 |0.00902090209020902 |4545 |10287 |FLNB,RANBP2,EIF4E,USP18,RAE1,UBE2N,PPM1B,KPNA1,EIF4G3,NUP210,NUP188,KPNA3,KPNA7,UBA52,NUP205,UBB,NUP85,STAT1,MX2,UBE2E1,MX1,EIF4A3,NUP214,EIF4A1,NUP35,NUP42,JAK1,TRIM25,NUP58,KPNA2,NEDD4,EIF4E3,EIF4G2,NUP93,DDX58,ISG15,SEH1L,UBC,NUP43,EIF4E2,KPNB1 R-HSA-1169410|Antiviral mechanism by IFN-stimulated genes |0.0547387594108291 |-2.90518323892877|76 |41 |0.00902090209020902 |4545 |10287 |STAT1,NUP85,UBB,NUP205,KPNA7,UBA52,KPNA1,NUP210,NUP188,EIF4G3,KPNA3,UBE2N,PPM1B,RANBP2,FLNB,RAE1,USP18,EIF4E,UBC,NUP43,EIF4E2,KPNB1,ISG15,SEH1L,NUP93,DDX58,KPNA2,NUP58,TRIM25,EIF4E3,EIF4G2,NEDD4,JAK1,NUP42,EIF4A3,NUP214,MX1,EIF4A1,NUP35,MX2,UBE2E1 R-HSA-171052 |LDL-mediated lipid transport |0.0548528765767409 |-2.90310064921052|24 |15 |0.0033003300330033 |4545 |10287 |APOB,PCSK9,MIR6886,AP2S1,LDLR,LIPA,SOAT1,AP2A2,LDLRAP1,SOAT2,AP2B1,CETP,AP2A1,NCEH1,AP2M1 R-HSA-2029485|Role of phospholipids in phagocytosis |0.0567469292506545 |-2.86915373420526|26 |16 |0.00352035203520352 |4545 |10287 |PIK3R2,CD247,PLPP5,AHCYL1,FCGR3A,PLCG2,ITPR2,PLA2G6,PIK3CB,ITPR1,PIK3R1,FCGR2A,ITPR3,PRKCD,PRKCE,PLD1 R-HSA-5610787|Hedgehog 'off' state |0.0568091309628454 |-2.86805820978683|101 |53 |0.0116611661166117 |4545 |10287 |PSMB8,IFT88,ADCY8,GNAS,PSMB3,ADCY1,PSMC2,SEM1,IFT57,ADCY4,ADCY10,PSMB1,PRKAR1A,UBA52,IFT172,BTRC,SKP1,PSMD12,PSMC4,PSMA1,ADCY9,UBB,IFT122,PSMB5,PTCH1,NUMB,PSMF1,PSMB9,PSMA6,PSMD14,TTC21B,GLI2,ADCY7,ITCH,PSMB10,PSMD3,PSMD7,PRKACA,PSME4,PSMA5,GSK3B,PSMA7,PSMD1,PSMB11,PSMA3,PSMB4,CUL1,RPGRIP1L,UBC,IFT52,ADCY3,PSMB7,MKS1 R-HSA-69239 |Synthesis of DNA |0.0568091309628454 |-2.86805820978683|101 |53 |0.0116611661166117 |4545 |10287 |PSMB11,PSMA3,PSMA7,PSMD1,POLD2,ORC6,DNA2,PSMB7,UBC,PSMB4,PSMD14,PRIM2,FZR1,MCM4,MCM3,PSMA5,PSME4,MCM5,RPA1,PSMD7,PSMB10,PSMD3,RFC2,PCNA,PSMB5,RPA3,UBB,ORC4,PSMC4,PSMD12,PSMA1,PSMA6,ORC2,GINS1,CCNA2,PSMB9,PSMF1,POLE3,RFC1,PSMC2,SEM1,RFC3,PSMB1,CDC6,RPA2,PSMB3,PSMB8,CDKN1A,CDT1,ORC5,POLE4,ORC1,UBA52 R-HSA-446203 |Asparagine N-linked glycosylation |0.0575769953914652 |-2.85463217662079|284 |139 |0.0305830583058306 |4545 |10287 |TRAPPC6A,GMPPB,RNF185,RPN2,MAN1A1,SPTAN1,NUS1,ALG13,CTSC,MAN1A2,TRAPPC10,SEL1L,SEC22B,CANX,NAPG,UBA52,SERPINA1,SYVN1,CNIH1,UGGT1,SLC35A1,NAPA,ENGASE,PGM3,GFPT2,GMDS,MGAT1,PPP6R1,MCFD2,ST3GAL5,MGAT4A,MAN1C1,AMFR,SLC35C1,DERL1,ANK2,EDEM2,SEC13,SAR1B,NEU3,ALG8,NEU4,ST3GAL1,SPTBN1,SEC24A,ANK3,GOSR2,B4GALT2,B4GALNT2,FCSK,DCTN4,SCFD1,RAB1A,F5,GNPNAT1,SEC23A,DAD1,ASGR2,COG7,TRAPPC6B,ALG9,GLB1,DYNC1LI1,COPG2,GFPT1,COG1,UBXN1,TUSC3,OS9,UBC,FOLR1,COPG1,TMED10,TRAPPC5,GNE,ANK1,NEU1,GOSR1,ST8SIA2,MIA2,KDELR3,COG3,DOLK,EDEM1,ST3GAL2,TSTA3,DYNC1I2,ARF1,NAPB,CD55,MGAT5,RNF139,ST3GAL4,TBC1D20,ST6GALNAC2,SEC23IP,RPN1,RAD23B,ST6GAL1,PPP6R3,DYNC1H1,MOGS,LMAN1,SLC17A5,UAP1,COG2,B4GALT5,MARCH6,RNF103,ARFGAP3,ALG2,ARFGAP1,SEC16A,RFT1,MANEA,DOLPP1,COPB2,ST3GAL6,PMM1,ALG10,ASGR1,DCTN2,USO1,TGFA,LMAN2L,MAN2A1,ST6GALNAC1,NANS,AREG,PPP6C,CHST10,ARFGAP2,CTSZ,SEC24D,SPTB,DPM1,DCTN1,ST6GALNAC4,UBB R-HSA-70268 |Pyruvate metabolism |0.058276311352383 |-2.84255959148411|28 |17 |0.00374037403740374 |4545 |10287 |HAGH,PPARD,PDPR,PDHX,RXRA,MPC1,PDK4,SLC16A3,PDK3,BSG,MIR6787,PDP1,LDHAL6B,LDHA,PDK1,GLO1,PDP2 R-HSA-1268020|Mitochondrial protein import |0.0590873058301153 |-2.82873916900966|62 |34 |0.00748074807480748 |4545 |10287 |CHCHD5,HSPA9,LDHD,FXN,SLC25A13,GRPEL1,TIMM8A,TOMM5,SLC25A12,PAM16,COX19,TOMM6,GRPEL2,GFER,ATP5F1A,TOMM40,PMPCB,CHCHD10,TIMM50,SAMM50,VDAC1,TIMM13,CS,TIMM44,CHCHD4,TIMM22,ACO2,TIMM21,COQ2,CMC2,DNAJC19,ATP5MC1,SLC25A4,HSCB R-HSA-5678895|Defective CFTR causes cystic fibrosis |0.0590873058301153 |-2.82873916900966|62 |34 |0.00748074807480748 |4545 |10287 |PSMB7,SEL1L,OS9,PSMB4,UBC,PSMA3,PSMB11,PSMD1,PSMA7,PSME4,PSMA5,RNF185,PSMB10,PSMD3,PSMD7,DERL1,ERLIN1,PSMD14,ERLEC1,PSMA6,PSMB9,PSMF1,ERLIN2,UBB,PSMB5,PSMA1,PSMD12,PSMC4,UBA52,PSMB1,PSMC2,SEM1,PSMB8,PSMB3 R-HSA-8866652|Synthesis of active ubiquitin: roles of E1 and E2 enzymes |0.0594951434288112 |-2.82186059280708|30 |18 |0.00396039603960396 |4545 |10287 |USP9X,UBE2D1,UBE2H,UBE2G1,UBC,CDC34,UBE2K,UBB,USP7,UBE2G2,UBE2B,UBA52,UBE2E1,UBE2W,UBE2C,UBE2R2,UBE2T,USP5 R-HSA-110314 |Recognition of DNA damage by PCNA-containing replication complex |0.0594951434288112 |-2.82186059280708|30 |18 |0.00396039603960396 |4545 |10287 |UBC,POLE3,RFC1,RFC2,PCNA,RPA3,UBB,POLD2,UBE2B,RPA1,DTL,POLE4,CUL4B,UBA52,RFC3,USP1,RPA2,RAD18 R-HSA-5387390|Hh mutants abrogate ligand secretion |0.0596290382782532 |-2.8196126041299 |60 |33 |0.00726072607260726 |4545 |10287 |PSMA3,PSMB11,PSMA7,PSMD1,PSMB7,SEL1L,UBC,PSMB4,OS9,SHH,PSMD14,PSMA5,IHH,PSME4,PSMD7,PSMB10,PSMD3,PSMB5,UBB,PSMA1,PSMD12,PSMC4,ERLEC1,PSMA6,PSMB9,PSMF1,PSMB1,SEM1,PSMC2,PSMB3,PSMB8,SYVN1,UBA52 R-HSA-5676590|NIK-->noncanonical NF-kB signaling |0.0596290382782532 |-2.8196126041299 |60 |33 |0.00726072607260726 |4545 |10287 |PSMB7,UBC,PSMB4,CUL1,MAP3K14,PSMB11,PSMA3,PSMD1,PSMA7,PSMA5,PSME4,PSMD7,PSMD3,PSMB10,NFKB2,PSMD14,PSMA6,PSMB9,PSMF1,PSMB5,FBXW11,UBB,PSMD12,PSMC4,PSMA1,SKP1,BTRC,UBA52,PSMC2,SEM1,PSMB1,PSMB3,PSMB8 R-HSA-193648 |NRAGE signals death through JNK |0.0596290382782532 |-2.8196126041299 |60 |33 |0.00726072607260726 |4545 |10287 |ARHGEF26,AATF,SOS1,FGD2,ARHGEF10L,ARHGEF4,FGD4,VAV3,MIR7706,VAV2,AKAP13,ARHGEF2,ARHGEF1,KALRN,ITSN1,ABR,PLEKHG2,ARHGEF10,PREX1,MCF2L,ARHGEF19,ARHGEF6,ARHGEF12,RASGRF2,NGEF,ARHGEF16,NET1,OBSCN,ARHGEF3,BCL2L11,ARHGEF7,TIAM2,TRIO R-HSA-5362768|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |0.0601400277656314 |-2.8110796397386 |58 |32 |0.00704070407040704 |4545 |10287 |SHH,PSMD14,PSMA5,PSME4,PSMD7,PSMD3,PSMB10,PSMA3,PSMB11,PSMD1,PSMA7,PSMB7,SEL1L,UBC,PSMB4,OS9,PSMB1,SEM1,PSMC2,PSMB3,PSMB8,SYVN1,UBA52,PSMB5,UBB,PSMA1,PSMD12,PSMC4,ERLEC1,PSMA6,PSMB9,PSMF1 R-HSA-2559585|Oncogene Induced Senescence |0.0604486102233766 |-2.80596169270048|32 |19 |0.00418041804180418 |4545 |10287 |MDM2,CDK6,TNRC6B,E2F2,TNRC6C,ID1,MAPK1,CDK4,TFDP2,CDKN2D,UBA52,CDKN2B,MDM4,UBB,E2F3,AGO3,UBC,ETS2,TNRC6A R-HSA-69610 |p53-Independent DNA Damage Response |0.0610497431563738 |-2.79606628553708|54 |30 |0.0066006600660066 |4545 |10287 |CHEK1,PSMB4,UBC,PSMB9,PSMF1,PSMA6,PSMB7,CHEK2,PSMC4,PSMD12,PSMA7,PSMD1,PSMA1,PSMB11,UBB,PSMA3,PSMB5,PSMD3,PSMB10,UBA52,PSMD7,PSME4,PSMA5,PSMD14,PSMB8,PSMB3,ATM,SEM1,PSMC2,PSMB1 R-HSA-69613 |p53-Independent G1/S DNA damage checkpoint |0.0610497431563738 |-2.79606628553708|54 |30 |0.0066006600660066 |4545 |10287 |UBB,PSMB5,PSMA3,PSMB11,PSMA1,PSMD12,PSMC4,PSMD1,PSMA7,PSMB7,CHEK2,PSMA6,PSMF1,PSMB9,CHEK1,PSMB4,UBC,PSMB1,PSMC2,SEM1,ATM,PSMB8,PSMD14,PSMB3,PSME4,PSMA5,PSMB10,UBA52,PSMD3,PSMD7 R-HSA-169911 |Regulation of Apoptosis |0.0610497431563738 |-2.79606628553708|54 |30 |0.0066006600660066 |4545 |10287 |PSMC2,SEM1,PSMB1,PSMB3,PSMD14,PSMB8,PAK2,OPA1,PSMA5,PSME4,PSMD7,PSMD3,OMA1,UBA52,PSMB10,PSMB11,PSMA3,PSMB5,UBB,PSMA7,PSMD1,PSMD12,PSMC4,PSMA1,PSMA6,PSMB7,UBC,PSMB4,PSMB9,PSMF1 R-HSA-69601 |Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |0.0610497431563738 |-2.79606628553708|54 |30 |0.0066006600660066 |4545 |10287 |PSMB10,UBA52,PSMD3,PSMD7,PSME4,PSMA5,PSMD14,PSMB8,PSMB3,ATM,PSMC2,SEM1,PSMB1,PSMB4,CHEK1,UBC,PSMF1,PSMB9,PSMA6,PSMB7,CHEK2,PSMC4,PSMD12,PSMD1,PSMA7,PSMA1,PSMB11,UBB,PSMA3,PSMB5 R-HSA-2173789|TGF-beta receptor signaling activates SMADs |0.0611745784467796 |-2.79402356061659|34 |20 |0.0044004400440044 |4545 |10287 |SMURF1,USP15,MTMR4,NEDD4L,XPO1,PPP1CC,STRAP,UBB,UBC,SMAD7,SMAD3,FURIN,TGFBR2,PPP1CB,PMEPA1,MIR6869,SMURF2,UBA52,SMAD4,PPP1R15A R-HSA-69229 |Ubiquitin-dependent degradation of Cyclin D1 |0.0614367144444955 |-2.78974766741089|52 |29 |0.00638063806380638 |4545 |10287 |PSMD12,PSMC4,PSMD1,PSMA7,PSMA1,PSMB11,UBB,PSMB5,PSMA3,PSMB4,UBC,PSMF1,PSMB9,PSMA6,PSMB7,PSMB8,PSMD14,PSMB3,SEM1,PSMC2,PSMB1,CCND1,UBA52,PSMD3,PSMB10,PSMD7,CDK4,PSME4,PSMA5 R-HSA-75815 |Ubiquitin-dependent degradation of Cyclin D |0.0614367144444955 |-2.78974766741089|52 |29 |0.00638063806380638 |4545 |10287 |PSMF1,PSMB9,PSMB4,UBC,PSMB7,PSMA6,PSMA1,PSMC4,PSMD12,PSMA7,PSMD1,UBB,PSMA3,PSMB5,PSMB11,PSMB10,UBA52,PSMD3,CDK4,PSMD7,CCND1,PSME4,PSMA5,PSMD14,PSMB8,PSMB3,PSMB1,PSMC2,SEM1 R-HSA-6806003|Regulation of TP53 Expression and Degradation |0.0617049192097722 |-2.78539162337576|36 |21 |0.00462046204620462 |4545 |10287 |RFFL,UBB,MDM4,PRDM1,USP7,PRR5,MTOR,UBC,CCNA2,CHEK2,PPP2CA,MDM2,RICTOR,ATM,PDPK1,USP2,AKT3,MAPKAP1,UBA52,SGK1,PPP2R1B R-HSA-112040 |G-protein mediated events |0.0620390706649362 |-2.77999092039695|48 |27 |0.00594059405940594 |4545 |10287 |ITPR1,ADCY8,CALM2,PLCB1,PLCB4,ADCY7,ADCY4,ADCY1,ITPR2,AHCYL1,MAPK1,PRKAR1A,PRKACA,CALM1,GNAZ,GNAI1,GNAI3,GNAL,GNAT1,PRKCD,ADCY9,ITPR3,ADCY3,CREB1,PRKCA,CAMK4,GNAI2 R-HSA-70153 |Glucose transport |0.0622369446613184 |-2.77680648994871|46 |26 |0.00572057205720572 |4545 |10287 |NUP93,NUP85,NUP58,NUP205,SLC2A2,SLC2A4,NUP43,GCKR,G6PC2,HK2,SLC2A14,SEH1L,NUP214,G6PC3,NUP35,RANBP2,SLC37A4,RAE1,FGF21,NUP42,GCK,NUP210,NUP188,G6PC,SLC2A1,SLC45A3 R-HSA-1442490|Collagen degradation |0.0622824421348442 |-2.77607572060072|40 |23 |0.00506050605060506 |4545 |10287 |ADAM9,MMP11,CTSB,COL9A2,TMPRSS6,COL14A1,MMP19,MMP20,MMP14,FURIN,CTSD,COL23A1,MMP15,ADAM17,COL16A1,MMP7,ELANE,MMP9,COL26A1,COL9A3,MMP2,CTSL,PHYKPL R-HSA-5693616|Presynaptic phase of homologous DNA pairing and strand exchange |0.0622824421348442 |-2.77607572060072|40 |23 |0.00506050605060506 |4545 |10287 |RAD51D,CHEK1,DNA2,RAD51B,RBBP8,RPA3,RAD9B,RHNO1,TOP3A,RFC2,RMI2,NBN,TOPBP1,RPA1,ATRIP,ATR,ATM,BRCA1,RPA2,EXO1,XRCC2,RFC3,BARD1 R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |0.0633241237326459 |-2.75948892081121|87 |46 |0.0101210121012101 |4545 |10287 |PIP5K1B,PPP2R5A,EGF,NRG4,FGF3,GRB2,INSR,PTPN11,PDGFRA,FRS2,CD80,HBEGF,BTC,PDGFA,CD28,NRG1,ERBB3,KL,FGFR4,FGF1,KITLG,FGF19,FGF20,PIK3R1,PIP4K2A,KLB,PIK3CB,FYN,FGFR3,PPP2R1B,FGF2,PIK3R2,FGF9,ERBB2,SRC,KIT,MAPK1,FGFR2,FGFR1,FGF10,PIK3AP1,PPP2CA,PDGFRB,PIP5K1A,PIK3R3,IRS1 R-HSA-5358351|Signaling by Hedgehog |0.0708982340797146 |-2.6465097529515 |138 |70 |0.0154015401540154 |4545 |10287 |PSMA7,GSK3B,SMURF1,P4HB,PSMB11,DZIP1,RPGRIP1L,UBC,OS9,ADCY3,SPOPL,MKS1,SEL1L,GLI2,PSMA5,GPC5,PSMC4,ADCY9,PSMB5,PSMB9,PSMF1,PSMA6,ADAM17,IFT88,ADCY8,PSMC2,ADCY10,PRKAR1A,SMURF2,SPOP,UBA52,SYVN1,IFT172,CDON,PSMD1,PSMA3,IFT52,PSMB4,CUL1,ARRB1,PSMB7,SHH,HHAT,PSMD14,TTC21B,ADCY7,ITCH,PSMD7,PSMD3,PSMB10,PRKACA,IHH,PSME4,PSMD12,PSMA1,IFT122,UBB,NUMB,PTCH1,ERLEC1,PSMB3,GNAS,PSMB8,IFT57,ADCY1,SEM1,PSMB1,ADCY4,SKP1,BTRC R-HSA-202403 |TCR signaling |0.0710159697202801 |-2.64485050159505|119 |61 |0.0134213421342134 |4545 |10287 |IKBKG,CSK,PSMD1,PSMA7,HLA-DPA1,CDC34,PSMA3,INPP5D,NFKB1,PSMB11,NFKBIA,CUL1,PSMB4,UBC,BCL10,PSMB7,UBE2D1,PAK2,FYB1,PDPK1,PSMD14,PAK3,CD101,RIPK2,PSMB10,PSMD3,PSMD7,NCK1,CD247,PSME4,PSMA5,PSMA1,PSMD12,PSMC4,UBB,TAB2,FBXW11,PSMB5,UBE2V1,PAG1,EVL,PSMB9,PSMF1,MALT1,PSMA6,CARD11,PIK3R1,ENAH,PSMB8,UBE2N,PIK3CB,PSMB3,PAK1,PSMB1,SEM1,PSMC2,UBA52,PTPRJ,PIK3R2,SKP1,BTRC R-HSA-69206 |G1/S Transition |0.0710159697202801 |-2.64485050159505|119 |61 |0.0134213421342134 |4545 |10287 |PSMF1,PSMB9,POLE3,PPP2CA,PSMA6,ORC2,CCNA2,ORC4,PSMD12,PSMC4,PSMA1,CCNH,PCNA,RPA3,PSMB5,TK2,UBB,POLE4,ORC1,CCND1,CDK4,TFDP2,DHFR,UBA52,PPP2R1B,SKP1,CDT1,ORC5,PSMB3,PSMB8,CDKN1A,PSMC2,SEM1,PSMB1,RPA2,CDC6,CCNE1,UBC,PSMB4,CUL1,CDC7,ORC6,WEE1,PSMB7,PSMA7,PSMD1,PPP2R3B,PSMA3,RPA1,MCM5,MCM10,PSMD7,PSMB10,PSMD3,MCM3,PSMA5,SKP2,PSMD14,PRIM2,MCM4,AKT3 R-HSA-2173791|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |0.0724055699124577 |-2.62547205005711|17 |11 |0.00242024202420242 |4545 |10287 |UBC,CGN,PARD3,UBA52,F11R,PRKCZ,TGFBR2,SMURF1,RHOA,MIR6869,UBB R-HSA-5655862|Translesion synthesis by POLK |0.0724055699124577 |-2.62547205005711|17 |11 |0.00242024202420242 |4545 |10287 |RPA1,UBC,UBA52,RFC1,REV1,RFC2,RFC3,PCNA,RPA2,RPA3,UBB R-HSA-69615 |G1/S DNA Damage Checkpoints |0.073183123970258 |-2.61479043144928|67 |36 |0.00792079207920792 |4545 |10287 |PSMB7,CCNE1,UBC,PSMB4,PSMA3,PSMB11,PSMD1,PSMA7,PSMA5,PSME4,PSMD7,PSMB10,PSMD3,MDM2,PSMD14,CHEK2,CCNA2,PSMA6,PSMF1,PSMB9,CHEK1,PSMB5,MDM4,UBB,PSMA1,PSMC4,PSMD12,UBA52,PSMB1,SEM1,PSMC2,CDKN1A,COP1,ATM,PSMB3,PSMB8 R-HSA-69563 |p53-Dependent G1 DNA Damage Response |0.0741666509974237 |-2.60144067731467|65 |35 |0.0077007700770077 |4545 |10287 |PSMA7,PSMD1,PSMA3,PSMB11,CCNE1,UBC,PSMB4,PSMB7,MDM2,PSMD14,PSMD7,PSMB10,PSMD3,PSMA5,PSME4,PSMA1,PSMD12,PSMC4,MDM4,PSMB5,UBB,PSMF1,PSMB9,CHEK2,CCNA2,PSMA6,COP1,ATM,CDKN1A,PSMB3,PSMB8,PSMB1,SEM1,PSMC2,UBA52 R-HSA-69580 |p53-Dependent G1/S DNA damage checkpoint |0.0741666509974237 |-2.60144067731467|65 |35 |0.0077007700770077 |4545 |10287 |PSMB7,CCNE1,UBC,PSMB4,PSMB11,PSMA3,PSMA7,PSMD1,PSMA5,PSME4,PSMD7,PSMD3,PSMB10,PSMD14,MDM2,PSMA6,CHEK2,CCNA2,PSMF1,PSMB9,MDM4,PSMB5,UBB,PSMC4,PSMD12,PSMA1,UBA52,PSMC2,SEM1,PSMB1,PSMB3,PSMB8,CDKN1A,COP1,ATM R-HSA-163200 |Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |0.0749307658692875 |-2.59119071352793|113 |58 |0.0127612761276128 |4545 |10287 |TMEM126B,COX16,NDUFA4,COX5A,NDUFAF6,ECSIT,COX7A2L,NDUFAF7,NDUFS1,COX5B,NDUFB4,TACO1,NDUFA11,ATP5PF,NDUFV2,ATP5F1D,COX14,ATP5ME,ATP5F1A,COX8A,LRPPRC,NDUFB9,NDUFA8,ATP5MC2,NDUFB6,NDUFS5,NDUFB7,ATP5MC3,NDUFAF5,UQCRFS1,NDUFAB1,COX4I1,UQCRC2,COX6C,ETFB,NDUFA12,COX6A1,NDUFS4,NDUFB3,UQCR10,NUBPL,COX11,COX18,NDUFC1,UCP3,NDUFS7,COX6B1,ATP5F1C,UQCRC1,COX20,COQ10B,ATP5MG,CYCS,ATP5MC1,UQCRB,ATP5PO,NDUFB11,SDHB R-HSA-110320 |Translesion Synthesis by POLH |0.075943543554972 |-2.57776506270496|19 |12 |0.00264026402640264 |4545 |10287 |UBC,NPLOC4,RPA1,UBA52,RFC1,PCNA,RFC3,RFC2,UBB,RPA3,RPA2,SPRTN R-HSA-5576886|Phase 4 - resting membrane potential |0.075943543554972 |-2.57776506270496|19 |12 |0.00264026402640264 |4545 |10287 |KCNJ4,KCNK15,KCNK3,KCNK17,KCNJ2,KCNK9,KCNK5,KCNK2,KCNK13,KCNK10,KCNK12,KCNK16 R-HSA-421270 |Cell-cell junction organization |0.0761045203336236 |-2.57564761596239|61 |33 |0.00726072607260726 |4545 |10287 |ANG,CDH11,CDH18,NECTIN4,PARD3,CDH4,PRKCI,AFDN,CLDN19,F11R,CTNNB1,CADM1,CDH5,CDH1,CLDN12,CLDN7,CTNNA1,CDH6,MPP5,CLDN14,CDH12,CDH17,CLDN1,PATJ,CLDN22,JUP,CDH10,CLDN23,CADM2,CDH2,PARD6G,CLDN4,PARD6B R-HSA-5610780|Degradation of GLI1 by the proteasome |0.0761045203336236 |-2.57564761596239|61 |33 |0.00726072607260726 |4545 |10287 |PSMD14,ITCH,PSMD7,PSMB10,PSMD3,PRKACA,PSMA5,PSME4,PSMA7,PSMD1,PSMB11,PSMA3,UBC,CUL1,PSMB4,PSMB7,PSMB3,PSMB8,SEM1,PSMC2,PSMB1,UBA52,BTRC,SKP1,PSMD12,PSMC4,PSMA1,PSMB5,UBB,NUMB,PSMB9,PSMF1,PSMA6 R-HSA-5607761|Dectin-1 mediated noncanonical NF-kB signaling |0.0761045203336236 |-2.57564761596239|61 |33 |0.00726072607260726 |4545 |10287 |PSMB5,FBXW11,UBB,PSMC4,PSMD12,PSMA1,PSMA6,PSMF1,PSMB9,PSMC2,SEM1,PSMB1,PSMB3,PSMB8,SKP1,BTRC,UBA52,PSMB11,PSMA3,PSMD1,PSMA7,PSMB7,UBC,CUL1,PSMB4,MAP3K14,PSMD14,PSMA5,PSME4,PSMD7,PSMD3,NFKB2,PSMB10 R-HSA-5610783|Degradation of GLI2 by the proteasome |0.0761045203336236 |-2.57564761596239|61 |33 |0.00726072607260726 |4545 |10287 |UBA52,SKP1,BTRC,PSMB8,PSMB3,PSMB1,SEM1,PSMC2,PSMB9,PSMF1,PSMA6,PSMA1,PSMD12,PSMC4,UBB,PSMB5,PSMB10,PSMD3,PSMD7,PSME4,PSMA5,PRKACA,PSMD14,GLI2,CUL1,PSMB4,UBC,PSMB7,GSK3B,PSMA7,PSMD1,PSMA3,PSMB11 R-HSA-187577 |SCF(Skp2)-mediated degradation of p27/p21 |0.0761045203336236 |-2.57564761596239|61 |33 |0.00726072607260726 |4545 |10287 |PSMA1,PSMD12,PSMC4,PSMB5,UBB,PSMF1,PSMB9,CCNA2,PSMA6,CDKN1A,PSMB3,PSMB8,PSMB1,SEM1,PSMC2,CDK4,UBA52,CCND1,SKP1,PSMA7,PSMD1,PSMA3,UBC,CCNE1,CUL1,PSMB4,PSMB7,SKP2,PSMD14,PSMD7,PSMD3,PSMB10,PSMA5 R-HSA-69242 |S Phase |0.0762703492755257 |-2.57347102335501|130 |66 |0.0145214521452145 |4545 |10287 |PSMB7,WEE1,CUL1,PSMB4,CCNE1,PSMA3,POLD2,PSMD1,RAD21,MCM3,PSME4,RPA1,MCM5,PSMD3,PSMB10,PSMD7,PDS5A,PSMD14,PRIM2,POLE3,ESCO1,UBB,PSMD12,ORC4,CCNH,PSMA1,ORC5,CDT1,SKP1,ORC1,SEM1,CDC6,PSMB1,PSMB8,PSMB3,STAG1,DNA2,ORC6,UBC,PSMB11,PSMA7,PSMA5,SKP2,MCM4,FZR1,PSMA6,CCNA2,ORC2,GINS1,CDC25B,RFC1,PSMB9,PSMF1,PCNA,RFC2,RPA3,PSMB5,PSMC4,CCND1,POLE4,UBA52,CDK4,PSMC2,RFC3,RPA2,CDKN1A R-HSA-68877 |Mitotic Prometaphase |0.0762861191129425 |-2.57326428236737|111 |57 |0.0125412541254125 |4545 |10287 |SEC13,CSNK2A1,NUP43,CENPU,NDEL1,CENPT,SEH1L,NCAPD2,CENPL,SKA1,MIR484,SGO2,RAD21,PPP1CC,SPC24,RPS27,KNL1,NDE1,CENPF,MAD1L1,RCC2,CDC20,HDAC8,ITGB3BP,TAOK1,CENPC,AHCTF1,CENPH,AURKB,KIF2B,PPP2R5A,PLK1,PDS5A,CLASP1,CLASP2,PPP2CA,NUDC,CSNK2A2,BUB1B,DSN1,BUB1,NUP85,CENPA,INCENP,XPO1,CLIP1,CKAP5,PPP2R1B,BUB3,CENPS,NSL1,STAG1,RANBP2,RANGAP1,KNTC1,CSNK2B,MAPRE1 R-HSA-2024096|HS-GAG degradation |0.0786673122254264 |-2.54252755640289|21 |13 |0.00286028602860286 |4545 |10287 |GPC1,HSPG2,SDC4,SDC1,GPC4,GPC5,SDC3,NAGLU,SDC2,GPC3,GLB1,GPC6,GUSB R-HSA-5654688|SHC-mediated cascade:FGFR1 |0.0786673122254264 |-2.54252755640289|21 |13 |0.00286028602860286 |4545 |10287 |NRAS,KL,FGF2,FGF9,FGF1,SOS1,SHC1,KRAS,FGF20,FGF3,FGFR1,GRB2,FGF10 R-HSA-75105 |Fatty Acyl-CoA Biosynthesis |0.0788847995468075 |-2.53976672435717|55 |30 |0.0066006600660066 |4545 |10287 |LHX4-AS1,SLC25A1,ELOVL3,ACLY,ACSL5,ACOT13,PCTP,ACSF2,ACOT12,TECR,ACOT1,ACACA,HACD2,ACOT11,ACOT7,ACSL3,MIR639,HACD1,ACSBG1,ACSBG2,ELOVL6,ELOVL5,ACSL6,ACBD6,ACSL4,ACOT2,ACSF3,FASN,DBI,ACSL1 R-HSA-349425 |Autodegradation of the E3 ubiquitin ligase COP1 |0.0797595703592672 |-2.52873854001223|53 |29 |0.00638063806380638 |4545 |10287 |PSME4,PSMA5,UBA52,PSMD3,PSMB10,PSMD7,PSMB1,PSMC2,SEM1,ATM,COP1,PSMD14,PSMB8,PSMB3,PSMB7,PSMA6,PSMF1,PSMB9,PSMB4,UBC,UBB,PSMB5,PSMA3,PSMB11,PSMA1,PSMC4,PSMD12,PSMA7,PSMD1 R-HSA-180534 |Vpu mediated degradation of CD4 |0.0797595703592672 |-2.52873854001223|53 |29 |0.00638063806380638 |4545 |10287 |UBA52,PSMD3,PSMB10,PSMD7,PSME4,PSMA5,BTRC,SKP1,PSMB8,PSMD14,PSMB3,PSMB1,SEM1,PSMC2,PSMB9,PSMF1,PSMB4,UBC,PSMB7,PSMA6,PSMA1,PSMC4,PSMD12,PSMD1,PSMA7,UBB,PSMA3,PSMB5,PSMB11 R-HSA-1630316|Glycosaminoglycan metabolism |0.0805941922295054 |-2.51832868877165|124 |63 |0.0138613861386139 |4545 |10287 |CHST14,ST3GAL1,SDC1,B3GAT2,GPC4,HAS2,B3GNT2,NDST2,HSPG2,CHST3,CSGALNACT1,PAPSS2,B3GNT7,CHST13,ST3GAL6,SDC3,XYLT2,SDC2,EXT1,CHST15,HS2ST1,HMMR,SDC4,GPC5,GPC1,CHP1,HEXB,FMOD,HS3ST6,HS3ST5,B4GALT5,GPC3,CHSY1,SLC35D2,HYAL3,SLC26A1,ST3GAL2,GPC6,GLB1,ST3GAL4,CHST5,GUSB,CHST7,NDST1,NAGLU,B3GALT6,B3GNT4,STAB2,MIR671,DSE,B4GALT2,LYVE1,HS3ST2,PAPSS1,B3GAT3,VCAN,GLCE,HS6ST1,HAS3,SLC9A1,CHST6,CHST9,ARSB R-HSA-1793185|Chondroitin sulfate/dermatan sulfate metabolism |0.0805986255446624 |-2.51827368241071|51 |28 |0.00616061606160616 |4545 |10287 |GPC5,SDC4,MIR671,HEXB,DSE,GPC1,CHSY1,GPC3,VCAN,B3GAT3,ARSB,CHST9,GPC4,B3GAT2,HYAL3,SDC1,CHST14,CSGALNACT1,CHST3,HSPG2,CHST7,GPC6,CHST15,XYLT2,SDC2,B3GALT6,CHST13,SDC3 R-HSA-211733 |Regulation of activated PAK-2p34 by proteasome mediated degradation |0.0805986255446624 |-2.51827368241071|51 |28 |0.00616061606160616 |4545 |10287 |PSMD7,PSMB10,PSMD3,UBA52,PSMA5,PSME4,PSMB3,PSMD14,PSMB8,PAK2,PSMC2,SEM1,PSMB1,UBC,PSMB4,PSMB9,PSMF1,PSMA6,PSMB7,PSMA7,PSMD1,PSMD12,PSMC4,PSMA1,PSMB11,PSMA3,PSMB5,UBB R-HSA-2500257|Resolution of Sister Chromatid Cohesion |0.0819733491398642 |-2.5013610950347 |103 |53 |0.0116611661166117 |4545 |10287 |NUP43,SEC13,CENPL,SEH1L,CENPT,NDEL1,CENPU,RAD21,SGO2,MIR484,SKA1,KNL1,RPS27,SPC24,PPP1CC,RCC2,CENPF,MAD1L1,NDE1,ITGB3BP,HDAC8,CDC20,CENPH,AURKB,AHCTF1,CENPC,TAOK1,PDS5A,PLK1,KIF2B,PPP2R5A,CLASP2,CLASP1,BUB1,DSN1,BUB1B,NUDC,PPP2CA,CENPA,NUP85,CLIP1,XPO1,INCENP,CKAP5,CENPS,BUB3,PPP2R1B,STAG1,NSL1,MAPRE1,KNTC1,RANGAP1,RANBP2 R-HSA-112043 |PLC beta mediated events |0.0821394656155925 |-2.49933667625048|47 |26 |0.00572057205720572 |4545 |10287 |PRKCD,ADCY9,GNAI3,GNAT1,GNAI1,GNAZ,CALM1,GNAI2,CAMK4,PRKCA,CREB1,ADCY3,ITPR3,ADCY1,ITPR2,ADCY7,ADCY4,PLCB1,PLCB4,ADCY8,CALM2,ITPR1,PRKACA,MAPK1,PRKAR1A,AHCYL1 R-HSA-933542 |TRAF6 mediated NF-kB activation |0.0822801134563609 |-2.49762583529263|25 |15 |0.0033003300330033 |4545 |10287 |HMGB1,NFKB1,RNF135,NFKBIA,NFKBIB,TRIM25,MAVS,APP,DDX58,IKBKG,AGER,TRAF2,MAP3K1,NFKB2,SAA1 R-HSA-69620 |Cell Cycle Checkpoints |0.0824760522012056 |-2.49524730412886|201 |99 |0.0217821782178218 |4545 |10287 |CCNE1,PSMB4,UBE2V2,HIST1H2BJ,WEE1,PSMB7,PSMD1,YWHAB,PSMA3,HIST1H4B,MCM5,RPA1,NBN,PSMD7,PSMD3,PSMB10,MCM3,PSME4,PSMD14,HIST1H2BL,ABRAXAS1,MDM2,CHEK1,HIST1H4E,BUB1B,ORC4,PSMD12,PSMA1,YWHAQ,RMI2,MDM4,UBB,TOPBP1,ORC1,ORC5,PSMB3,PSMB8,UBE2N,BRCA1,ATM,NSD2,BARD1,EXO1,SEM1,PSMB1,CDC6,HIST1H4D,UBC,UIMC1,HIST1H2BH,CDC7,UBE2D1,ORC6,DNA2,HIST1H2BO,PSMA7,ANAPC15,HIST1H4I,TOP3A,PSMB11,YWHAG,HIST1H4K,MCM10,MAD1L1,ATR,CDC20,YWHAZ,PSMA5,ATRIP,HIST1H4H,ANAPC7,MCM4,UBE2C,UBE2E1,PSMB9,PSMF1,PSMA6,ORC2,CHEK2,RNF8,CCNA2,RBBP8,ANAPC4,PSMC4,RFC2,RHNO1,RAD9B,PSMB5,RPA3,HIST1H2BC,UBA52,TP53BP1,BUB3,CDKN1A,COP1,MDC1,RFC3,PSMC2,RPA2 R-HSA-5654716|Downstream signaling of activated FGFR4 |0.0833906059777806 |-2.4842196141177 |27 |16 |0.00352035203520352 |4545 |10287 |FGFR4,SHC1,FRS3,FGF1,PIK3R1,GRB2,KLB,FGF19,KRAS,FGF20,SOS1,PTPN11,NRAS,FRS2,FGF9,FGF2 R-HSA-373760 |L1CAM interactions |0.0834642567007462 |-2.48333680223476|101 |52 |0.0114411441144114 |4545 |10287 |CSNK2A1,SCN5A,SCN1A,SCN2B,ANK3,RPS6KA2,SPTBN1,RANBP9,DPYSL2,ANK1,KIF4B,DLG1,AP2A1,AP2M1,HSPA8,RPS6KA1,LAMB1,ITGA2,SPTAN1,ANK2,MAP2K1,NUMB,SCN9A,ITGB1,RDX,AP2S1,VAV2,CSNK2A2,SPTB,FGFR1,LAMC1,NRP2,NRP1,SCN8A,SCN7A,ITGB3,NRCAM,SRC,SCN4A,ALCAM,MAPK1,ITGA1,CHL1,SHTN1,RPS6KA3,AP2A2,AP2B1,PAK1,DNM2,CSNK2B,NFASC,GAP43 R-HSA-375170 |CDO in myogenesis |0.0841462298776543 |-2.47519916175356|29 |17 |0.00374037403740374 |4545 |10287 |MEF2B,MAPK14,MAP2K6,BNIP2,CDON,NTN3,CDH4,NEO1,TCF12,CTNNA1,ABL1,CDC42,SPAG9,MEF2A,CTNNB1,TCF3,CDH2 R-HSA-525793 |Myogenesis |0.0841462298776543 |-2.47519916175356|29 |17 |0.00374037403740374 |4545 |10287 |CDH2,SPAG9,CTNNB1,MEF2A,TCF3,ABL1,CTNNA1,CDC42,TCF12,CDH4,NEO1,CDON,NTN3,MAP2K6,MAPK14,BNIP2,MEF2B R-HSA-163841 |Gamma carboxylation, hypusine formation and arylsulfatase activation |0.0843809818032761 |-2.47241323685617|39 |22 |0.00484048404840484 |4545 |10287 |F7,PROZ,PROS1,EEF2,F2,DPH6,SUMF2,ARSA,DPH3,FURIN,FN3K,ARSI,DHPS,STS,ARSB,GGCX,DPH5,PROC,FN3KRP,F10,DOHH,ARSG R-HSA-5674135|MAP2K and MAPK activation |0.0843809818032761 |-2.47241323685617|39 |22 |0.00484048404840484 |4545 |10287 |RAF1,MARK3,VCL,VWF,ARRB1,FGG,CSK,YWHAB,ITGB3,SRC,FGB,PEBP1,MAPK1,NRAS,BRAF,FGA,FN1,KSR1,KSR2,IQGAP1,KRAS,MAP2K1 R-HSA-111465 |Apoptotic cleavage of cellular proteins |0.0843809818032761 |-2.47241323685617|39 |22 |0.00484048404840484 |4545 |10287 |BIRC2,DSG2,DSG1,PTK2,PLEC,CASP8,LMNB1,SPTAN1,LMNA,ADD1,BCAP31,CTNNB1,GSN,DSP,CDH1,GAS2,PRKCD,ROCK1,TJP2,STK24,ACIN1,FNTA R-HSA-418990 |Adherens junctions interactions |0.0846082263010316 |-2.46972377949638|31 |18 |0.00396039603960396 |4545 |10287 |CTNNB1,CADM2,CADM1,CDH2,CDH5,CDH1,CTNNA1,ANG,CDH6,CDH11,CDH18,NECTIN4,CDH17,CDH12,CDH4,AFDN,JUP,CDH10 R-HSA-5654733|Negative regulation of FGFR4 signaling |0.0846082263010316 |-2.46972377949638|31 |18 |0.00396039603960396 |4545 |10287 |PPP2CA,FGFR4,SPRY2,FGF1,UBC,UBB,PTPN11,BRAF,FRS2,FGF9,FGF2,UBA52,SRC,MAPK1,FGF19,FGF20,GRB2,KLB R-HSA-5654726|Negative regulation of FGFR1 signaling |0.0848259775272968 |-2.46715344433113|33 |19 |0.00418041804180418 |4545 |10287 |FGF3,GRB2,FGF20,SRC,UBA52,MAPK1,PTPN11,BRAF,FGF2,FGF9,FRS2,FGFR1,FGF10,UBB,FGF1,UBC,SPRY2,KL,PPP2CA R-HSA-6804757|Regulation of TP53 Degradation |0.0848396644115579 |-2.46699210483853|35 |20 |0.0044004400440044 |4545 |10287 |PDPK1,ATM,USP2,RICTOR,MDM2,AKT3,UBA52,MAPKAP1,PPP2R1B,SGK1,RFFL,PRR5,USP7,MDM4,UBB,UBC,MTOR,PPP2CA,CHEK2,CCNA2 R-HSA-5619115|Disorders of transmembrane transporters |0.085291466736755 |-2.46168086774476|76 |40 |0.0088008800880088 |4545 |10287 |PSMA6,ERLEC1,ERLIN2,GCKR,PSMF1,PSMB9,ALB,PSMB5,UBB,PSMD12,PSMC4,PSMA1,UBA52,SEM1,PSMC2,AVPR1A,PSMB1,PSMB3,PSMB8,SEL1L,PSMB7,UBC,PSMB4,OS9,PSMB11,PSMA3,PSMD1,PSMA7,PSMA5,RNF185,PSME4,SFTPA1,PSMD7,GCK,DERL1,PSMB10,PSMD3,ERLIN1,ABCC8,PSMD14 R-HSA-8876198|RAB GEFs exchange GTP for GDP on RABs |0.0930318228242941 |-2.37481366345303|89 |46 |0.0101210121012101 |4545 |10287 |DENND1A,TRAPPC6B,RAB8B,RIN3,HPS1,DENND4C,RAB10,ANKRD27,DENND3,GAPVD1,RAB14,RIN2,RAB39B,TRAPPC12,DENND5A,DENND4A,RAB1A,RAB3GAP1,DENND1B,RAB7A,SBF1,ST5,RAB21,RAB5B,RAB27A,RAB32,DENND2A,RIC1,RAB6A,HPS4,MON1A,RAB5C,RAB31,RABGEF1,TRAPPC10,RAB12,RAB27B,TRAPPC8,TRAPPC5,ALS2,AKT3,RAB3IP,MON1B,TRAPPC6A,SBF2,RAB35 R-HSA-8873719|RAB geranylgeranylation |0.0939801652663756 |-2.36467152678193|64 |34 |0.00748074807480748 |4545 |10287 |RAB3B,RAB27B,RAB20,RAB12,RAB31,RAB5C,RAB6A,RAB40C,RAB37,RAB32,RAB33B,RAB40A,RAB35,RAB3D,PTP4A2,RAB39B,RAB11A,RAB14,RAB10,RAB25,RAB17,RAB2A,RAB22A,RAB4A,RAB43,RAB36,RABGGTA,RAB8B,RAB21,RAB27A,RAB5B,RAB30,RAB7A,RAB1A R-HSA-174143 |APC/C-mediated degradation of cell cycle proteins |0.0947351653126251 |-2.35667001389881|87 |45 |0.0099009900990099 |4545 |10287 |BTRC,SKP1,BUB3,UBA52,PSMC2,SEM1,PSMB1,PSMB3,PSMB8,PSMA6,BUB1B,CCNA2,PSMF1,PSMB9,PSMB5,UBB,PSMD12,ANAPC4,PSMC4,PSMA1,CDC20,PSMA5,NEK2,PSME4,PSMD7,PSMB10,PSMD3,UBE2C,UBE2E1,PLK1,SKP2,PSMD14,ANAPC7,FZR1,AURKB,UBE2D1,PSMB7,UBC,PSMB4,CUL1,PSMB11,PSMA3,PSMD1,PSMA7,ANAPC15 R-HSA-453276 |Regulation of mitotic cell cycle |0.0947351653126251 |-2.35667001389881|87 |45 |0.0099009900990099 |4545 |10287 |UBB,PSMB5,PSMC4,ANAPC4,PSMD12,PSMA1,PSMA6,CCNA2,BUB1B,PSMB9,PSMF1,SEM1,PSMC2,PSMB1,PSMB8,PSMB3,BUB3,BTRC,SKP1,UBA52,PSMB11,PSMA3,PSMD1,ANAPC15,PSMA7,UBE2D1,PSMB7,CUL1,PSMB4,UBC,UBE2C,PLK1,UBE2E1,ANAPC7,PSMD14,SKP2,AURKB,FZR1,CDC20,PSME4,NEK2,PSMA5,PSMB10,PSMD3,PSMD7 R-HSA-1445148|Translocation of GLUT4 to the plasma membrane |0.0954689368386985 |-2.34895435311152|62 |33 |0.00726072607260726 |4545 |10287 |RALA,PRKAB1,ASPSCR1,MYH1,TBC1D4,VAMP2,RAB4A,C2CD5,YWHAQ,RAB11A,RAB14,PRKAB2,KIF3B,RAB10,STX4,RALGAPB,MYH13,MYH4,CALM2,RALGAPA2,EXOC7,RHOQ,MYO1C,YWHAZ,CALM1,EXOC8,TBC1D1,YWHAB,YWHAG,EXOC6,SLC2A4,PRKAG2,PRKAG1 R-HSA-5578775|Ion homeostasis |0.0999648423828765 |-2.30293673098267|56 |30 |0.0066006600660066 |4545 |10287 |ATP1A1,CAMK2B,ATP2B4,CAMK2G,ITPR2,SLC8A3,FKBP1B,ATP2B3,ITPR1,CALM2,CAMK2D,FXYD2,PRKACA,MIR4687,ATP2A2,ORAI1,ATP1B3,AHCYL1,ATP2B2,ATP2B1,ATP2A1,ATP1B1,ATP1A2,CALM1,SRI,CAMK2A,TRPC1,FXYD1,NOS1,ITPR3 R-HSA-176408 |Regulation of APC/C activators between G1/S and early anaphase |0.100042102294613 |-2.30216415865321|81 |42 |0.00924092409240924 |4545 |10287 |UBE2C,PLK1,UBE2E1,PSMD14,ANAPC7,FZR1,CDC20,PSMA5,PSME4,PSMD7,PSMD3,PSMB10,PSMB11,PSMA3,ANAPC15,PSMA7,PSMD1,UBE2D1,PSMB7,UBC,CUL1,PSMB4,SEM1,PSMC2,PSMB1,PSMB3,PSMB8,BTRC,SKP1,BUB3,UBA52,PSMB5,UBB,PSMD12,ANAPC4,PSMC4,PSMA1,PSMA6,BUB1B,CCNA2,PSMB9,PSMF1 R-HSA-189200 |Hexose transport |0.101462969914708 |-2.2880613754929 |54 |29 |0.00638063806380638 |4545 |10287 |NUP85,NUP93,SLC2A2,SLC5A9,NUP205,NUP58,GCKR,G6PC2,SLC5A10,NUP43,SLC2A4,SEH1L,SLC2A14,HK2,NUP35,G6PC3,NUP214,RAE1,SLC37A4,RANBP2,GCK,NUP42,SLC2A5,FGF21,SLC2A1,SLC45A3,G6PC,NUP210,NUP188 R-HSA-3214858|RMTs methylate histone arginines |0.101878325760835 |-2.28397606244883|79 |41 |0.00902090209020902 |4545 |10287 |H2AFZ,CDK4,H2AFV,CCND1,WDR5,PRMT1,SMARCA4,SMARCB1,SMARCE1,HIST1H2AG,ACTL6B,HIST1H4D,JAK2,SMARCD3,PBRM1,COPRS,HIST1H4E,SMARCD2,HIST1H2AA,HIST1H4K,RBBP7,H2AFJ,PRMT7,HIST1H3J,HIST2H2AB,HIST1H4H,SMARCA2,PRMT3,ARID2,CARM1,SMARCC2,WDR77,ARID1B,SMARCD1,HIST1H4I,HIST1H2AK,PRMT6,HIST1H2AE,DNMT3A,HIST1H4B,HIST1H3C R-HSA-202424 |Downstream TCR signaling |0.102781677713432 |-2.27514817420596|98 |50 |0.011001100110011 |4545 |10287 |UBB,TAB2,FBXW11,PSMB5,UBE2V1,PSMA1,PSMD12,PSMC4,PSMA6,PSMB9,PSMF1,MALT1,PSMB1,SEM1,PSMC2,PIK3R1,CARD11,UBE2N,PSMB8,PIK3CB,PSMB3,PIK3R2,SKP1,BTRC,UBA52,HLA-DPA1,CDC34,NFKB1,PSMA3,INPP5D,PSMB11,NFKBIA,IKBKG,PSMD1,PSMA7,PSMB7,UBE2D1,PSMB4,CUL1,BCL10,UBC,RIPK2,PDPK1,PSMD14,PSME4,PSMA5,PSMB10,PSMD3,PSMD7,CD247 R-HSA-69017 |CDK-mediated phosphorylation and removal of Cdc6 |0.10295418849379 |-2.27347116159782|52 |28 |0.00616061606160616 |4545 |10287 |UBC,PSMB4,PSMF1,PSMB9,PSMA6,PSMB7,PSMA7,PSMD1,PSMC4,PSMD12,PSMA1,PSMB11,PSMA3,PSMB5,UBB,PSMD7,PSMB10,PSMD3,UBA52,PSMA5,PSME4,PSMB3,PSMD14,PSMB8,PSMC2,SEM1,CDC6,PSMB1 R-HSA-392499 |Metabolism of proteins |0.103095396588811 |-2.2721005389191 |1619 |739 |0.162596259625963 |4545 |10287 |RAB35,DYNC1H1,NSMCE3,PSMD3,RAD23B,SEC23IP,PIGC,SMC5,MAVS,EIF4B,STAT3,ACHE,TNKS2,COPB2,SEH1L,RFT1,SORL1,SMAD3,ARFGAP3,TOMM5,ARFGAP1,PSMB4,DCTN2,USP15,CALM1,RAD21,LMAN2L,NUP188,SRP9,PIGN,NUP210,SCMH1,SIAH2,RPL38,ACO2,ST6GALNAC1,KLF4,VDAC1,CTSZ,ARFGAP2,CSNK2A2,RPS4Y2,RNF128,PPP6C,GNAT1,PMPCB,RNF123,DCTN1,SAMM50,TIMM50,TSPYL2,BIRC2,COPG2,GALNT2,FOXK2,SLC30A6,EXOC7,RPL36,TFAP2C,RPL13,YY1,STS,COG1,CALM2,RAB3B,TRAPPC5,HIST1H2BH,COPG1,CXCL8,EIF2S3,RAB31,RAB6A,EIF2B2,TATDN2,IKBKG,CXXC1,EIF3D,PIGU,F10,SRPRB,INHA,USP10,COG3,ATP6AP2,MUC13,INO80D,MIA2,NAPB,CPB2,ADORA2B,HIF1A,SEMA5B,MSRB3,DYNC1I2,UBE2G1,SAA1,ST6GALNAC2,ST3GAL4,RNF139,RAB40A,DERL1,SLC35C1,DIS3,DDIT3,ASNS,MDM2,ABRAXAS1,PSMB7,SPTBN1,ST3GAL1,TCF7L2,FFAR4,OTUB1,EIF4EBP1,RPL19,TBCE,BCL10,CHCHD5,EIF3E,PFDN4,RAB5B,FKBP9,N6AMT1,CSNK2B,DAD1,TIMM44,P2RY2,RAB1A,COG7,TRAF3,INHBE,GALNT17,TBCD,GNAI3,RAB22A,CCDC59,NUP85,ALG9,USP49,HIST1H3J,USP11,EEF1AKMT1,ATF6,ADAMTS13,PCSK2,GALNT10,UBE2E1,RPS21,B3GNT8,COX19,THBS1,POMK,UIMC1,IGF1,NEGR1,CTSC,MUC2,GNB5,CTR9,RPL10A,RAB33B,NSMCE1,UBE2B,EEF1A1,SYVN1,CRHR2,XBP1,FBXO6,USP18,ENGASE,IGFBP4,OTUB2,PSMC2,DPP4,RPLP1,TGFBR2,UGGT1,MCFD2,RPS15,TRAM1,MGAT1,NTM,GMDS,EEF2,AMFR,SMAD1,MAN1C1,APOA1,ZRANB1,THBS2,ST6GAL1,RUVBL1,WDR61,COG2,OGT,SEC16A,OPCML,GIP,SLC25A13,ACTB,ASGR1,ALG10,B3GNT9,APOA4,MUC5B,BIRC3,RPS20,USP3,SPON1,TGFA,CMC2,AREG,XRN2,ARSB,TECTA,PSMB8,ALPL,TIMM13,B3GNTL1,GNAI2,ESR1,CHST10,NTNG2,RAB11A,UBB,ST6GALNAC4,CCP110,SPTB,ARSG,TOMM6,PHC1,NUP42,EP300,DYNC1LI1,GNG10,UBE2C,FBXW2,TIMM8A,PARN,RAB20,FURIN,PTRH2,HNRNPC,EIF2AK3,MBTPS1,EXTL3,ATF4,OS9,VNN3,NEU1,NUP58,OTUD7B,HIST1H2BO,FBXL3,CCT5,B3GNT4,SLC25A4,RPL26,HDGF,DOLK,PGAP1,APEH,COQ2,PHC2,HIST1H2AG,METTL21A,FN3K,OTOA,ST3GAL2,IGFBP6,POMGNT2,B3GNT5,PDIA5,SLC34A2,CD55,MGAT5,DPH6,KEAP1,DOHH,GRPEL2,DHPS,RIPK2,ADAMTS2,UBE2I,TUBB1,AXIN1,ANK3,NEU4,CCT3,NEU3,NUP43,B3GNT2,IGFBP1,HIST1H2AE,HIST1H4B,RPS5,NOD1,PSMD1,TBCA,GNAI1,SMAD4,PSMB1,EIF4E,UBE2R2,SEM1,GGCX,F5,LONP2,ADA2,MYSM1,PTP4A2,RPL23,GNG7,POFUT2,PROZ,SP3,GLB1,VAMP2,RABGGTA,APP,TXN,TRAPPC6B,DAG1,STX1A,RPL22L1,GNG4,PRKDC,CBX4,PAPPA,PIGA,UBE2D1,CST3,RPS27,SUMO3,SEC22B,LDHD,RAB32,MELTF,RAB27A,SEC11A,GALNT11,ACADVL,USP34,USP25,RAB30,HIST1H2BC,UBA52,EIF5,NAPA,PIGX,CS,LYPD2,TIMM21,KDM1B,CCNA2,PPP6R1,PSMA6,PSMB9,EXOSC3,CHCHD10,SEC62,ST3GAL5,PSMC4,SLC17A5,MOGS,MMP2,RNF20,PSMD7,RPA1,RPL34,RPS15A,SPHK1,HIST1H2BL,UAP1,DNAJB11,ARRB1,GRPEL1,TAB1,DOLPP1,RNF103,ALG2,GALNT12,RGS9,USO1,RPL24,RNF135,TECTB,SUMF2,ST3GAL6,ADRM1,RPS19,ATP5MC1,RANBP2,RANGAP1,MBTPS2,USP28,MUC3A,RPL13A,SEC24D,C1GALT1,KIFC3,ETFB,INCENP,ASXL2,LEP,MAT2B,WRAP53,ETF1,TUSC3,NUP35,ATP6V0D1,AURKB,HIST1H4H,GALNT13,PARP1,ADAMTS10,TMED10,TRAF2,SMAD7,DNAJC3,RAB5C,UBE2K,RPL15,RAB40C,PSMB11,CPE,EXOSC9,CNTN4,FGA,HSCB,USP14,RAE1,KIF5B,KDELR3,LMNA,USP48,TNKS,GET3,EIF2S2,TSTA3,EDEM1,PDCL,PSMB5,EIF4H,PCNA,TOMM40,RPL18A,ARSA,AGT,MIR6805,RAB8B,FN3KRP,USP47,HIST1H2AA,PSMB10,EDEM2,SLC25A12,GALNT15,ZDHHC2,UBE2T,HERPUD1,ANK2,CTSD,RAB12,HIST1H2BJ,SEC13,CCNE1,INO80C,WDR20,SHC1,RIPK1,B3GNT7,ASXL1,PABPC1,OTUD7A,TNIP1,TUBA3E,RCE1,B4GALNT2,DNAJC19,B4GALT2,ASGR2,UBE2W,CHCHD4,CNTN5,SEC23A,PSMB3,USP5,UBE2N,EEF2KMT,ADAMTS6,KAT2B,MDM4,RAD23A,MIR4738,FOXK1,RNF146,PSMD12,RNF185,RPN2,RPL5,PSMA5,GMPPB,MBD6,HSPA5,TRAPPC6A,INHBB,ARFGEF2,HIST1H4K,RPL21,PCSK1,SPTAN1,PAM16,MAN1A1,RAB27B,NSMCE2,HSPG2,ATXN7,RPL31,ACTR5,NAPG,UBE2D3,TRIM25,UBE2G2,HIST1H3C,USP7,NSMCE4A,CANX,PGA5,HIST1H2AK,F2,RPS11,CNIH1,FBXO4,EIF2B5,SERPINA1,CTSH,ADRA2A,FBXW5,SMURF2,TOP2B,SENP5,ADAMTS17,USP2,SEC61G,MDC1,SLC35A1,KIF13A,RAB14,CPN1,RAB25,RAB2A,CTDSP2,GSK3A,DPH3,LMAN1,PSME4,HIST2H2AB,PPP6R3,DPH5,RPN1,RPS13,MARCH6,INHBC,B4GALT5,RPS3A,SUDS3,DCAF7,MANEA,CKAP4,EXOC6,RAB37,OTUD5,FXN,MSRB1,PMM1,USP13,NUP93,RPS9,IGFBP3,RPL9,GNGT2,TIMM22,NANS,GBA,STAG1,GALNT14,MAN2A1,SEC11C,EIF3A,HIST1H4E,SPON2,STAM,VDAC2,GATA4,MIR7-1,B3GLCT,NOD2,SENP8,IL33,RAB4A,DPM1,PSMA1,RPS16,SUMO2,CDC20,PIGG,SEC63,RPS24,GFER,UBXN1,NUP214,GFPT1,GNE,CSNK2A1,FOLR1,POMC,UBC,SLC30A5,HSPA9,RTN4RL2,ANK1,HIST1H4I,HYOU1,USP22,ST8SIA2,PROC,ERN1,GOSR1,THY1,CBX8,ARSI,RAB39B,WFS1,ARF1,ADAMTSL1,JOSD1,RAB10,TBC1D20,NUP205,IGF2,ANPEP,EIF5B,IGFBP5,TGFBI,EIF2B3,LYPD6B,ATP5F1A,RAB3D,GCNT3,SFTPA1,AOPEP,VDAC3,ZBTB17,PRMT3,NFYA,PSMD14,CCT2,CTNNB1,SEC24A,ALG8,ITM2B,SAR1B,PSMA3,INO80,NFKBIA,PROS1,GOSR2,TBCB,EXOC8,ATF3,SCFD1,DCTN4,H2AFZ,TOP1,RAB7A,FCSK,HIST1H4D,BARD1,GNPNAT1,LARGE1,BRCA1,USP9X,UBE2H,DCP2,POLB,RAB17,F7,RAB43,RAB36,RPL32,GCNT1,GNB4,HSPA8,SRP54,NFYC,PIGF,ALG13,CPM,NUS1,CAMKMT,EIF4A1,SKP2,RPL12,SEL1L,AXIN2,ADD1,TRAPPC10,MAN1A2,RPL23A,CDC34,SEC61A1,CMA1,RHOA,DDX58,PIAS1,PSMA7,GPLD1,RAB21,TP53BP1,GALNT4,ADAMTSL4,THSD4,GFPT2,PGM3,SP100,SSR3,RPLP2,SIAH1,PSMF1,USP4,GSPT1,GSN,ADRA2C,PHC3,MGAT4A,CETN2,GNAZ,WIPI1 R-HSA-2173793|Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |0.107330244902077 |-2.23184479672408|46 |25 |0.0055005500550055 |4545 |10287 |SKI,TGIF1,RBL1,SERPINE1,NCOR2,E2F5,SMURF2,JUNB,SMAD4,UBA52,TFDP2,CDKN2B,WWTR1,UBE2D3,CDK8,CCNT2,UBB,NEDD4L,TRIM33,UBE2D1,PARP1,USP9X,UBC,SMAD7,SMAD3 R-HSA-174178 |APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |0.107594624973184 |-2.22938458628301|73 |38 |0.00836083608360836 |4545 |10287 |PSMD7,PSMD3,PSMB10,CDC20,PSMA5,PSME4,SKP2,PSMD14,ANAPC7,FZR1,AURKB,UBE2C,UBE2E1,PLK1,UBC,PSMB4,UBE2D1,PSMB7,PSMA7,ANAPC15,PSMD1,PSMB11,PSMA3,UBA52,PSMB3,PSMB8,PSMC2,SEM1,PSMB1,PSMF1,PSMB9,PSMA6,ANAPC4,PSMD12,PSMC4,PSMA1,PSMB5,UBB R-HSA-611105 |Respiratory electron transport |0.108838653469084 |-2.21788873679849|92 |47 |0.0103410341034103 |4545 |10287 |COX6B1,COX20,COQ10B,UQCRC1,COX11,NUBPL,NDUFS7,NDUFC1,COX18,SDHB,NDUFB11,CYCS,UQCRB,COX4I1,UQCRC2,COX6C,ETFB,NDUFB7,UQCRFS1,NDUFAB1,NDUFAF5,UQCR10,COX6A1,NDUFA12,NDUFB3,NDUFS4,NDUFA11,NDUFV2,TACO1,NDUFB4,NDUFB9,NDUFA8,NDUFS5,NDUFB6,COX14,LRPPRC,COX8A,NDUFAF6,COX7A2L,ECSIT,COX16,TMEM126B,COX5A,NDUFA4,NDUFS1,NDUFAF7,COX5B R-HSA-69656 |Cyclin A:Cdk2-associated events at S phase entry |0.109570366682853 |-2.21118831800794|71 |37 |0.00814081408140814 |4545 |10287 |PSMD12,PSMC4,PSMA1,CCNH,UBB,PSMB5,PSMF1,PSMB9,PSMA6,CCNA2,CDC25B,PSMB8,PSMB3,CDKN1A,SEM1,PSMC2,PSMB1,CCND1,UBA52,CDK4,SKP1,PSMD1,PSMA7,PSMA3,PSMB4,CUL1,UBC,CCNE1,PSMB7,WEE1,PSMD14,SKP2,FZR1,PSMD3,PSMB10,PSMD7,PSMA5 R-HSA-69481 |G2/M Checkpoints |0.110819598572518 |-2.19985163788736|169 |83 |0.0182618261826183 |4545 |10287 |WEE1,PSMB7,PSMB4,UBE2V2,HIST1H2BJ,PSMA3,HIST1H4B,PSMD1,YWHAB,MCM3,PSME4,MCM5,RPA1,NBN,PSMD7,PSMD3,PSMB10,HIST1H2BL,ABRAXAS1,PSMD14,HIST1H4E,CHEK1,YWHAQ,RMI2,UBB,ORC4,PSMD12,PSMA1,ORC5,TOPBP1,ORC1,NSD2,BARD1,SEM1,EXO1,PSMB1,CDC6,HIST1H4D,PSMB3,BRCA1,PSMB8,UBE2N,ATM,HIST1H2BH,CDC7,ORC6,DNA2,UBC,UIMC1,TOP3A,PSMB11,YWHAG,PSMA7,HIST1H2BO,HIST1H4I,YWHAZ,ATR,PSMA5,ATRIP,HIST1H4K,MCM10,HIST1H4H,MCM4,PSMA6,ORC2,CHEK2,RNF8,PSMF1,PSMB9,RFC2,RAD9B,RHNO1,PSMB5,RPA3,RBBP8,PSMC4,TP53BP1,UBA52,HIST1H2BC,PSMC2,RFC3,RPA2,MDC1 R-HSA-8864260|Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |0.111390308066182 |-2.19471495647501|40 |22 |0.00484048404840484 |4545 |10287 |VEGFA,CITED1,NOP2,TGFA,EP300,ATAD2,KIT,WWOX,ERBB2,MYBL2,YY1,UBE2I,KCTD1,TFAP2C,CDKN1A,CREBBP,KDM5B,TFAP2E,ESR1,CITED4,KCTD15,CITED2 R-HSA-5654741|Signaling by FGFR3 |0.111390308066182 |-2.19471495647501|40 |22 |0.00484048404840484 |4545 |10287 |UBB,SPRY2,FRS3,SHC1,UBC,FGF1,PPP2CA,GRB2,PIK3R1,FGF20,KRAS,SOS1,MAPK1,UBA52,SRC,FGF9,FRS2,FGFR3,FGF2,PTPN11,BRAF,NRAS R-HSA-5619084|ABC transporter disorders |0.111581647615646 |-2.19299869044644|69 |36 |0.00792079207920792 |4545 |10287 |PSMD14,ABCC8,ERLIN1,PSMB10,PSMD3,PSMD7,DERL1,SFTPA1,PSME4,RNF185,PSMA5,PSMD1,PSMA7,PSMA3,PSMB11,OS9,PSMB4,UBC,SEL1L,PSMB7,PSMB8,PSMB3,PSMB1,PSMC2,SEM1,UBA52,PSMA1,PSMD12,PSMC4,UBB,PSMB5,PSMF1,PSMB9,ERLIN2,ERLEC1,PSMA6 R-HSA-156590 |Glutathione conjugation |0.112619257212239 |-2.18374255470006|38 |21 |0.00462046204620462 |4545 |10287 |GSTO2,GCLC,CHAC2,GGT5,GGCT,GSTA3,GSS,GSTO1,MGST1,HPGDS,GSTA1,CNDP2,ESD,GCLM,MGST2,CHAC1,GGT1,AKR1A1,OPLAH,GSTP1,MGST3 R-HSA-5685938|HDR through Single Strand Annealing (SSA) |0.112619257212239 |-2.18374255470006|38 |21 |0.00462046204620462 |4545 |10287 |NBN,RPA1,TOPBP1,ATR,ATRIP,BRCA1,ATM,RFC3,EXO1,BARD1,RPA2,ERCC4,DNA2,RBBP8,ABL1,RHNO1,RAD9B,RFC2,RMI2,TOP3A,RPA3 R-HSA-196757 |Metabolism of folate and pterines |0.113483374911655 |-2.17609892933871|18 |11 |0.00242024202420242 |4545 |10287 |ALDH1L1,MTHFD1L,SLC25A32,SLC19A1,DHFR,FPGS,SHMT2,MTHFD2,MTHFR,MTHFD2L,SLC46A1 R-HSA-4608870|Asymmetric localization of PCP proteins |0.113628568472032 |-2.17482032128319|67 |35 |0.0077007700770077 |4545 |10287 |FZD2,SCRIB,UBA52,SMURF2,PSMB1,FZD4,PSMC2,SEM1,PSMB3,PSMB8,PSMA6,PSMB9,PSMF1,PSMB5,UBB,PSMA1,PSMC4,PSMD12,PSMA5,PSME4,PSMD7,FZD7,PSMB10,PSMD3,FZD5,WNT5A,PSMD14,PSMB7,UBC,PSMB4,PSMA3,PSMB11,SMURF1,PSMD1,PSMA7 R-HSA-532668 |N-glycan trimming in the ER and Calnexin/Calreticulin cycle |0.113758095913837 |-2.17368105081485|36 |20 |0.0044004400440044 |4545 |10287 |OS9,EDEM1,UBC,RNF103,SEL1L,CANX,RNF139,UBB,AMFR,RAD23B,UBA52,DERL1,SYVN1,RNF185,MOGS,UGGT1,MARCH6,EDEM2,UBXN1,ENGASE R-HSA-212718 |EGFR interacts with phospholipase C-gamma |0.113758095913837 |-2.17368105081485|36 |20 |0.0044004400440044 |4545 |10287 |ADCY3,ITPR3,CREB1,CAMK4,PRKCA,CALM1,ADCY9,PRKCD,PRKCE,AHCYL1,PRKAR1A,PRKACA,EGF,ADCY8,CALM2,ITPR1,ADCY4,ADCY7,ITPR2,ADCY1 R-HSA-1489509|DAG and IP3 signaling |0.114784416357823 |-2.16469955032299|34 |19 |0.00418041804180418 |4545 |10287 |CALM1,PRKCE,ADCY9,PRKCD,ITPR3,ADCY3,CREB1,PRKCA,CAMK4,ITPR1,ADCY8,CALM2,ADCY7,ADCY4,ADCY1,ITPR2,AHCYL1,PRKAR1A,PRKACA R-HSA-5656169|Termination of translesion DNA synthesis |0.114784416357823 |-2.16469955032299|34 |19 |0.00418041804180418 |4545 |10287 |RPA2,USP10,RFC3,UBA52,RPA1,POLE4,POLD2,RPA3,UBB,RFC2,TRIM25,PCNA,POLE3,RFC1,POLI,UBC,REV1,ISG15,USP43 R-HSA-5694530|Cargo concentration in the ER |0.114784416357823 |-2.16469955032299|34 |19 |0.00418041804180418 |4545 |10287 |GOSR2,SEC22B,SEC24D,MCFD2,SEC24A,CTSZ,TMED10,FOLR1,SAR1B,CTSC,AREG,F5,SEC23A,MIA2,CNIH1,LMAN1,LMAN2L,SERPINA1,TGFA R-HSA-73847 |Purine metabolism |0.114784416357823 |-2.16469955032299|34 |19 |0.00418041804180418 |4545 |10287 |PNP,APRT,DGUOK,XDH,GPX1,GMPR2,ADSS,ADSSL1,ADK,LHPP,PFAS,NT5E,IMPDH1,DCK,GMPR,NT5C2,GDA,IMPDH2,CAT R-HSA-5654719|SHC-mediated cascade:FGFR4 |0.11531229005062 |-2.16011126544818|20 |12 |0.00264026402640264 |4545 |10287 |GRB2,KLB,KRAS,FGF19,FGF20,FGFR4,SHC1,FGF1,SOS1,NRAS,FGF9,FGF2 R-HSA-5654706|FRS-mediated FGFR3 signaling |0.11531229005062 |-2.16011126544818|20 |12 |0.00264026402640264 |4545 |10287 |KRAS,FGF20,GRB2,PTPN11,NRAS,FRS2,FGF9,FGF2,FGFR3,FRS3,FGF1,SOS1 R-HSA-68962 |Activation of the pre-replicative complex |0.115670589831582 |-2.15700887042629|32 |18 |0.00396039603960396 |4545 |10287 |ORC4,RPA3,POLE3,ORC2,ORC6,CDC7,MCM4,PRIM2,RPA2,CDC6,MCM10,POLE4,ORC1,MCM5,RPA1,ORC5,CDT1,MCM3 R-HSA-70263 |Gluconeogenesis |0.115670589831582 |-2.15700887042629|32 |18 |0.00396039603960396 |4545 |10287 |SLC25A13,MDH1,PGK2,GOT1,PCK1,ALDOA,PRKACA,PGK1,PCK2,GAPDH,GPI,FBP1,SLC25A1,GOT2,SLC25A10,SLC25A12,ALDOB,MDH2 R-HSA-381042 |PERK regulates gene expression |0.116382266003279 |-2.15087510921556|30 |17 |0.00374037403740374 |4545 |10287 |ATF6,HSPA5,NFYC,DDIT3,DIS3,NFYA,ASNS,HERPUD1,DCP2,PARN,EIF2AK3,CXCL8,EXOSC3,ATF4,IGFBP1,EXOSC9,ATF3 R-HSA-140837 |Intrinsic Pathway of Fibrin Clot Formation |0.116422419418707 |-2.15053015554116|22 |13 |0.00286028602860286 |4545 |10287 |SERPINA5,F2,SERPINC1,F11,KNG1,GP1BA,SERPIND1,PRCP,PROC,SERPINE2,A2M,VWF,F10 R-HSA-203765 |eNOS activation and regulation |0.116422419418707 |-2.15053015554116|22 |13 |0.00286028602860286 |4545 |10287 |HSP90AA1,DHFR,GCH1,NOSIP,WASL,SPR,GCHFR,CAV1,CALM1,LYPLA1,CALM2,DNM2,PTS R-HSA-373753 |Nephrin interactions |0.116422419418707 |-2.15053015554116|22 |13 |0.00286028602860286 |4545 |10287 |SPTBN1,PIK3R2,WASL,FYN,CASK,NCK1,ACTN1,IQGAP1,NCK2,ACTN4,PIK3CB,SPTAN1,PIK3R1 R-HSA-140875 |Common Pathway of Fibrin Clot Formation |0.116422419418707 |-2.15053015554116|22 |13 |0.00286028602860286 |4545 |10287 |FGB,SERPIND1,F10,PROC,SERPINE2,FGA,F13A1,FGG,F5,SERPINC1,SERPINA5,F2,PROS1 R-HSA-202131 |Metabolism of nitric oxide |0.116422419418707 |-2.15053015554116|22 |13 |0.00286028602860286 |4545 |10287 |CALM2,CAV1,LYPLA1,CALM1,PTS,DNM2,NOSIP,GCH1,HSP90AA1,DHFR,SPR,GCHFR,WASL R-HSA-4641263|Regulation of FZD by ubiquitination |0.116422419418707 |-2.15053015554116|22 |13 |0.00286028602860286 |4545 |10287 |FZD4,RSPO1,UBB,LRP5,LGR6,RNF43,RSPO3,RSPO4,ZNRF3,FZD5,UBC,LGR5,UBA52 R-HSA-397014 |Muscle contraction |0.116856061590084 |-2.14681234437411|204 |99 |0.0217821782178218 |4545 |10287 |NOS1,VCL,KCNE3,SCN5A,KCNK12,SCN1A,PXN,ATP1A2,MYH11,MIR4687,CACNA1D,DYSF,MYL10,CALM2,NEB,KCNK15,KCNJ4,FXYD2,CACNG4,KCNK17,ATP2B4,TMOD1,FXYD1,TRPC1,SCN9A,TMOD3,ITPR3,MYL12B,MYL4,TPM1,KCNJ2,HIPK1,HIPK2,SCN8A,ATP2B1,ITGA1,ATP2A2,MYL6B,MYBPC3,CACNG1,KCNE4,MYLK,ATP1B3,ORAI1,KCNK16,FKBP1B,ITPR2,CAMK2B,ATP1A1,KCNK9,KCNK5,KCNK10,KCNK2,CACNA2D4,DMD,SCN2B,CALM1,ATP1B1,WWTR1,TPM4,ITGB5,ATP2B2,TCAP,AHCYL1,SORBS1,PRKACA,ANXA1,NKX2-5,ATP2B3,ITPR1,CAMK2D,KCNQ1,SORBS3,CALD1,KAT2B,CACNG6,KCNK13,SRI,CAMK2A,ANXA2,ATP2A1,CACNB3,CACNB4,KCNIP4,MYL6,SCN7A,GATA4,TNNC2,MYL9,FGF14,TPM3,AKAP9,SCN4A,ANXA6,CACNA2D3,MYBPC1,CAMK2G,KCNK3,SLC8A3 R-HSA-112315 |Transmission across Chemical Synapses |0.11686842139593 |-2.14670658047894|217 |105 |0.0231023102310231 |4545 |10287 |PDPK1,SLC1A3,COMT,MDM2,CAMK2D,GRIK4,GRIP2,PLCB1,ADCY7,NEFL,RPS6KA1,CASK,CACFD1,PRKACA,GABBR2,KCNJ10,CALM1,CACNA1E,GNAI1,SLC6A12,ACHE,CACNA1A,RPS6KA2,SLC1A7,TSPAN7,MAOA,CHRNA9,AP2B1,RASGRF1,ADCY4,SLC38A2,SYN3,ADCY1,CAMK2G,AKAP9,APBA1,SLC6A1,MAPK1,GNGT2,STXBP1,GLS,CACNA2D3,CHRNB3,PICK1,CACNB4,ABAT,CACNB3,KCNJ3,GABRR2,GNAI3,VAMP2,CREB1,CAMK2A,CAMK4,GNAI2,GNG7,PPFIA3,CHRNA6,GRIA3,CACNG4,KCNJ4,LIN7A,CALM2,CHRNA1,GNG10,GRIN2A,GNG4,HSPA8,GABRA2,STX1A,GNB4,CPLX1,GRIK3,DLG1,GNAL,AP2A1,AP2M1,GNB5,RASGRF2,ADCY3,PRKCA,SLC1A2,CHRNA2,MIR4761,SLC6A11,AP2A2,ADCY8,SLC6A4,CAMK2B,SLC38A1,SLC22A2,BRAF,CHRNE,RPS6KA3,PPFIA1,GLS2,NAAA,ALDH5A1,KCNJ2,ADCY9,RAF1,DNAJC5,AP2S1,NPTN,ALDH2 R-HSA-437239 |Recycling pathway of L1 |0.11687633214372 |-2.14663889341711|28 |16 |0.00352035203520352 |4545 |10287 |KIF4B,AP2M1,AP2A1,NUMB,RDX,AP2S1,RPS6KA2,DPYSL2,AP2A2,AP2B1,DNM2,SRC,RPS6KA1,MAPK1,RPS6KA3,SHTN1 R-HSA-937041 |IKK complex recruitment mediated by RIP1 |0.116977293282694 |-2.14577543752617|24 |14 |0.00308030803080308 |4545 |10287 |UBE2D1,BIRC2,BIRC3,SARM1,UBC,UBA52,UBE2V1,UBE2D3,UBB,RIPK1,CD14,UBE2N,LY96,IKBKG R-HSA-5357956|TNFR1-induced NFkappaB signaling pathway |0.117098091919271 |-2.14474330296664|26 |15 |0.0033003300330033 |4545 |10287 |BIRC3,TAB1,XIAP,TRAF2,TNFRSF1A,BIRC2,USP4,TRAF1,RIPK1,TAB2,RBCK1,OTUD7B,USP2,IKBKG,TAB3 R-HSA-1971475|A tetrasaccharide linker sequence is required for GAG synthesis |0.117098091919271 |-2.14474330296664|26 |15 |0.0033003300330033 |4545 |10287 |VCAN,GPC3,B3GAT3,GPC6,B3GALT6,SDC2,XYLT2,SDC3,GPC5,B3GAT2,GPC4,SDC1,SDC4,HSPG2,GPC1 R-HSA-446219 |Synthesis of substrates in N-glycan biosythesis |0.117829140627 |-2.13851966461286|63 |33 |0.00726072607260726 |4545 |10287 |NUS1,UAP1,GFPT1,ST6GAL1,SLC35C1,GMPPB,SLC17A5,ST3GAL6,PMM1,NEU1,NEU3,DOLPP1,GNE,NEU4,ST3GAL1,GNPNAT1,SLC35A1,DOLK,PGM3,GFPT2,ST6GALNAC1,NANS,FCSK,ST8SIA2,DPM1,ST3GAL5,ST6GALNAC2,ST3GAL4,ST6GALNAC4,GLB1,ST3GAL2,TSTA3,GMDS R-HSA-380287 |Centrosome maturation |0.119872675534146 |-2.12132513671402|82 |42 |0.00924092409240924 |4545 |10287 |AKAP9,HSP90AA1,CKAP5,HAUS4,ODF2,MAPRE1,HAUS3,PLK4,CSNK1E,CEP152,DYNC1I2,CLASP1,CEP57,CETN2,PCNT,CCP110,CEP63,CNTRL,CEP72,DCTN1,CEP76,NDE1,NINL,DYNC1H1,NEK2,PRKACA,TUBB,NUMA1,CEP70,CEP78,HAUS6,PLK1,NEDD1,CEP164,PCM1,CDK5RAP2,CEP250,MIR484,TUBGCP5,YWHAG,DCTN2,CEP192 R-HSA-380270 |Recruitment of mitotic centrosome proteins and complexes |0.119872675534146 |-2.12132513671402|82 |42 |0.00924092409240924 |4545 |10287 |DCTN2,CEP192,YWHAG,TUBGCP5,MIR484,CEP250,CDK5RAP2,PCM1,CEP164,PLK1,HAUS6,CEP78,NEDD1,CEP70,DYNC1H1,NEK2,NINL,NUMA1,TUBB,PRKACA,CEP76,NDE1,CEP72,DCTN1,CCP110,PCNT,CETN2,CNTRL,CEP63,CEP57,DYNC1I2,CEP152,CSNK1E,CLASP1,MAPRE1,PLK4,HAUS3,ODF2,HAUS4,AKAP9,HSP90AA1,CKAP5 R-HSA-8852276|The role of GTSE1 in G2/M progression after G2 checkpoint |0.119982322942028 |-2.12041085586753|61 |32 |0.00704070407040704 |4545 |10287 |PSMA3,PSMB11,PSMA7,PSMD1,HSP90AB1,PSMB7,UBC,PSMB4,PLK1,PSMD14,PSMA5,PSME4,PSMD7,PSMD3,PSMB10,PSMB5,UBB,PSMA1,PSMD12,PSMC4,PSMA6,PSMB9,PSMF1,PSMB1,MAPRE1,PSMC2,SEM1,CDKN1A,PSMB3,PSMB8,UBA52,HSP90AA1 R-HSA-5610785|GLI3 is processed to GLI3R by the proteasome |0.119982322942028 |-2.12041085586753|61 |32 |0.00704070407040704 |4545 |10287 |PSMA7,PSMD1,GSK3B,PSMA3,PSMB11,UBC,CUL1,PSMB4,PSMB7,PSMD14,PSMD7,PSMD3,PSMB10,PSMA5,PSME4,PRKACA,PSMA1,PSMD12,PSMC4,PSMB5,UBB,PSMB9,PSMF1,PSMA6,PSMB3,PSMB8,PSMB1,PSMC2,SEM1,UBA52,SKP1,BTRC R-HSA-983168 |Antigen processing: Ubiquitination & Proteasome degradation |0.121049128688836 |-2.11155879356833|311 |148 |0.0325632563256326 |4545 |10287 |FBXO6,FBXW5,SMURF2,KBTBD7,UBE2J2,UBA52,UBE2B,FBXO41,RNF7,FBXO4,ASB1,ZNRF1,PSMC2,UNKL,RNF114,RBBP6,UBR2,PSMF1,PSMB9,SPSB1,SIAH1,PSMA6,ANAPC4,PSMC4,UBE2V1,FBXW11,RBCK1,KLHL11,PSMA5,TRAF7,SKP2,FZR1,UBE2E1,SOCS3,ASB7,SOCS1,FBXO7,RNF14,UBE2D1,FBXO17,PSMA7,MYLIP,SMURF1,FBXO31,UBE2D3,UBE2G2,CDC34,ARIH2,SKP1,UBE2F,PSMB3,RLIM,UBE2N,ELOC,UBE2R2,UBE2W,SEM1,PSMB1,UBOX5,LONRF1,UBE2H,ZBTB16,UBE2Q1,PSMD12,NEDD4L,TRIM50,ITCH,UBAC1,KLHL21,PSMB10,ASB3,KEAP1,FBXO21,CUL2,TRIM71,PSMD14,KCTD6,FBXO22,KBTBD13,FBXO44,MEX3C,ATG7,PSMB7,PSMD1,LTN1,PSMA3,HACE1,FBXO27,UBA5,KLHL5,ASB14,RNF41,CBLB,KLHL20,UBE2G1,UBE2J1,HECTD2,ASB2,UBE3C,HECTD1,PSMB5,WWP1,CDC20,RNF138,FBXW2,RNF144B,KLHL2,ANAPC7,UBE2C,UBC,ASB13,UBE2D4,RNF213,FBXL3,TRIM11,PSMB11,UBE2K,RNF19A,SIAH2,UBE4A,BTRC,KCTD7,RNF182,WSB1,PSMB8,KLHL41,RNF130,UBE2O,RNF217,TRIM37,PSMA1,RNF123,UBB,FBXO32,PSMD7,PSMD3,TRIM69,PSME4,FBXW8,VHL,CUL1,PSMB4,UBE2V2,ASB4,FBXL19,LMO7,FBXO15,NEDD4 R-HSA-597592 |Post-translational protein modification |0.121883743661083 |-2.10468760937735|1034 |475 |0.104510451045105 |4545 |10287 |EDEM1,UBE2G1,DYNC1I2,TSTA3,HIF1A,SEMA5B,NAPB,TNKS,RAB8B,ARSA,RNF139,PCNA,ST3GAL4,ST6GALNAC2,PSMB5,USP14,PIGU,F10,CNTN4,USP48,MIA2,INO80D,MUC13,KDELR3,COG3,USP10,RAE1,RAB31,RAB5C,SMAD7,COPG1,TRAF2,ADAMTS10,HIST1H2BH,TMED10,PARP1,TRAPPC5,RAB3B,IKBKG,PSMB11,RAB40C,UBE2K,RAB6A,FOXK2,GALNT2,COPG2,BIRC2,MAT2B,GALNT13,CALM2,STS,YY1,COG1,NUP35,AURKB,TFAP2C,TUSC3,PPP6C,RNF128,ARFGAP2,CTSZ,C1GALT1,VDAC1,SEC24D,ASXL2,DCTN1,RNF123,INCENP,ETFB,SIAH2,SCMH1,PIGN,ADRM1,NUP188,NUP210,LMAN2L,USP28,MUC3A,ST6GALNAC1,RANBP2,RANGAP1,GALNT12,PSMB4,RNF103,ALG2,ARFGAP3,ARFGAP1,SMAD3,RFT1,TAB1,DOLPP1,TNKS2,SEH1L,COPB2,ARRB1,ST3GAL6,SUMF2,CALM1,RAD21,TECTB,USP15,RNF135,DCTN2,USO1,SEC23IP,RAD23B,RPA1,PSMD3,PSMD7,RNF20,NSMCE3,RAB35,DYNC1H1,MOGS,SLC17A5,HIST1H2BL,UAP1,MAVS,SMC5,PIGC,GMDS,NTM,RAB25,RAB14,MGAT1,MCFD2,DPH3,MAN1C1,RAB2A,SMAD1,AMFR,EEF2,SMURF2,SERPINA1,SYVN1,EEF1A1,UBE2B,NSMCE1,CNIH1,UGGT1,TGFBR2,SLC35A1,MDC1,USP2,ADAMTS17,PSMC2,SENP5,OTUB2,TOP2B,USP18,ENGASE,MUC2,CTSC,ATXN7,NEGR1,UIMC1,POMK,RAB27B,NSMCE2,F2,RAB33B,HIST1H2AK,CANX,NSMCE4A,CTR9,TRIM25,UBE2G2,USP7,UBE2D3,NAPG,ACTR5,GALNT10,TRAPPC6A,ADAMTS13,MBD6,USP11,GMPPB,EEF1AKMT1,PSMA5,RNF185,USP49,RPN2,MAN1A1,THBS1,SPTAN1,B3GNT8,UBE2E1,KAT2B,ADAMTS6,TRAF3,EEF2KMT,COG7,RNF146,ALG9,PSMD12,NUP85,FOXK1,RAB22A,GALNT17,RAD23A,MDM4,B4GALT2,B4GALNT2,RCE1,RAB5B,USP5,UBE2N,PSMB3,RAB1A,CNTN5,SEC23A,DAD1,UBE2W,ASGR2,INO80C,WDR20,BCL10,SEC13,HIST1H2BJ,OTUB1,SPTBN1,ST3GAL1,RAB12,PSMB7,TNIP1,OTUD7A,ASXL1,B3GNT7,RIPK1,SLC35C1,PSMB10,USP47,HIST1H2AA,DERL1,FN3KRP,RAB40A,ANK2,ABRAXAS1,UBE2T,MDM2,GALNT15,EDEM2,RAB10,JOSD1,ADAMTSL1,ST3GAL2,ARF1,FN3K,OTOA,RAB39B,METTL21A,DPH6,CD55,MGAT5,B3GNT5,POMGNT2,TBC1D20,NUP205,CBX8,THY1,GOSR1,B3GNT4,PROC,ST8SIA2,HIST1H2AG,PHC2,PGAP1,ARSI,DOLK,OS9,VNN3,UBC,FOLR1,HNRNPC,PTRH2,RAB20,FURIN,GNE,USP22,HIST1H2BO,ANK1,OTUD7B,RTN4RL2,NEU1,NUP58,DYNC1LI1,EP300,PHC1,NUP42,PIGG,CDC20,ARSG,SUMO2,GFPT1,NUP214,UBXN1,UBE2C,RAB11A,VDAC2,SPON2,STAM,NTNG2,CHST10,ESR1,B3GNTL1,PSMA1,SPTB,CCP110,DPM1,IL33,RAB4A,ST6GALNAC4,SENP8,B3GLCT,UBB,NOD2,MIR7-1,TGFA,USP3,SPON1,BIRC3,PSMB8,MAN2A1,TECTA,ALPL,GALNT14,STAG1,ARSB,NANS,AREG,SEC16A,OPCML,OGT,MANEA,NUP93,MUC5B,PMM1,USP13,RAB37,OTUD5,B3GNT9,ALG10,ASGR1,ACTB,RPN1,RUVBL1,ST6GAL1,DPH5,HIST2H2AB,PPP6R3,PSME4,THBS2,LMAN1,ZRANB1,SUDS3,WDR61,COG2,B4GALT5,MARCH6,PSMB9,USP4,PSMF1,PSMA6,PPP6R1,KDM1B,CCNA2,ST3GAL5,PSMC4,CETN2,MGAT4A,PHC3,THSD4,HIST1H2BC,UBA52,ADAMTSL4,GALNT4,RAB30,USP34,USP25,TP53BP1,GALNT11,RAB27A,RAB21,MELTF,LYPD2,SP100,PIGX,NAPA,GFPT2,PGM3,MAN1A2,TRAPPC10,UBE2D1,PIGA,AXIN2,SEL1L,GPLD1,RAB32,PSMA7,PIAS1,DDX58,SEC22B,RHOA,SUMO3,CDC34,HSPA8,GCNT1,SKP2,CAMKMT,NUS1,CPM,ALG13,CBX4,PRKDC,PIGF,POLB,UBE2H,POFUT2,PTP4A2,MYSM1,USP9X,DAG1,TRAPPC6B,RABGGTA,RAB43,RAB36,F7,SP3,GLB1,PROZ,RAB17,RAB7A,FCSK,SMAD4,TOP1,DCTN4,SCFD1,BRCA1,LARGE1,GNPNAT1,F5,GGCX,SEM1,UBE2R2,BARD1,PSMB1,B3GNT2,NUP43,SAR1B,NEU3,NEU4,ALG8,SEC24A,ANK3,AXIN1,PSMD1,NOD1,NFKBIA,PROS1,GOSR2,INO80,PSMA3,HIST1H2AE,VDAC3,GCNT3,RAB3D,LYPD6B,DOHH,KEAP1,PSMD14,UBE2I,ADAMTS2,RIPK2,PRMT3,DHPS R-HSA-204998 |Cell death signalling via NRAGE, NRIF and NADE |0.127117679954573 |-2.06264200774957|76 |39 |0.00858085808580858 |4545 |10287 |ITGB3BP,ARHGEF10,SQSTM1,MCF2L,PREX1,ARHGEF6,ARHGEF19,NCSTN,RASGRF2,ARHGEF12,UBC,OBSCN,ARHGEF16,NGEF,NET1,TRIO,TIAM2,ARHGEF7,BCL2L11,ARHGEF3,ARHGEF26,ARHGEF4,UBA52,ARHGEF10L,AATF,FGD2,SOS1,FGD4,VAV2,MIR7706,VAV3,ARHGEF1,ARHGEF2,AKAP13,UBB,ABR,KALRN,ITSN1,PLEKHG2 R-HSA-179419 |APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |0.129646052635842 |-2.04294721377148|74 |38 |0.00836083608360836 |4545 |10287 |PSMC2,SEM1,PSMB1,PSMB3,PSMB8,BUB3,UBA52,PSMB5,UBB,ANAPC4,PSMD12,PSMC4,PSMA1,PSMA6,BUB1B,CCNA2,PSMB9,PSMF1,UBE2C,UBE2E1,PSMD14,ANAPC7,CDC20,PSMA5,NEK2,PSME4,PSMD7,PSMB10,PSMD3,PSMB11,PSMA3,ANAPC15,PSMA7,PSMD1,UBE2D1,PSMB7,UBC,PSMB4 R-HSA-1912422|Pre-NOTCH Expression and Processing |0.135956130456066 |-1.99542301545902|47 |25 |0.0055005500550055 |4545 |10287 |TNRC6C,TFDP2,CCND1,ATP2A2,EP300,RBPJ,CREBBP,TNRC6B,SEL1L,NOTCH3,AGO3,FURIN,TNRC6A,AGO2,MFNG,KAT2B,RAB6A,ST3GAL4,MAML1,JUN,E2F3,ST3GAL6,ATP2A1,MIR1825,NOTCH1 R-HSA-5368286|Mitochondrial translation initiation |0.136363806830492 |-1.99242891460072|87 |44 |0.00968096809680968 |4545 |10287 |MRPL55,MRPL46,MRPL16,MRPL35,MRPL3,MRPS18B,MRPS17,MRPS5,MTIF2,MRPL22,MRPS16,MRPS21,CHCHD1,MRPS36,MRPS28,MRPL13,MRPS25,MRPS9,MRPS33,MRPL1,MRPS10,MRPL14,MTIF3,MRPL44,MRPL4,PTCD3,MRPL17,MRPL10,MRPL19,MRPL2,MRPS35,MRPS27,MRPL54,MRPL18,MRPL34,MRPS14,MRPL33,MRPL48,MRPS18A,MRPS15,MRPS23,MRPL30,MRPL15,MRPL53 R-HSA-1834949|Cytosolic sensors of pathogen-associated DNA |0.13759530655202 |-1.98343846342495|68 |35 |0.0077007700770077 |4545 |10287 |AGER,IKBKG,RIPK1,NFKB1,HMGB1,NFKBIA,POLR2E,POLR3A,UBC,XRCC5,CTNNB1,POLR3GL,PRKDC,STAT6,NFKB2,POLR3B,POLR3E,POLR3H,EP300,TRIM56,APP,CRCP,XRCC6,UBB,TBK1,TMEM173,SAA1,DTX4,DDX41,LRRFIP1,POLR1D,NFKBIB,CREBBP,UBA52,CGAS R-HSA-111885 |Opioid Signalling |0.139162687139309 |-1.97211161917435|85 |43 |0.00946094609460946 |4545 |10287 |PLCB4,GNG10,PLCB1,ADCY7,LOC729966,ITPR1,PDE4B,CALM2,PRKACA,GNB4,GNG4,AHCYL1,GNB5,GNAL,PDE4A,PRKCD,CALM1,GNAI1,PRKCA,OPRM1,ADCY3,POMC,ADCY4,PPP3CA,ITPR2,ADCY1,PDE4D,ADCY8,PPP2R1B,PRKAR1A,MAPK1,GNGT2,PPP1R1B,GNAT1,GNAI3,ADCY9,GNAZ,CAMK4,GNG7,GNAI2,PPP2CA,ITPR3,CREB1 R-HSA-5693579|Homologous DNA Pairing and Strand Exchange |0.140743581246095 |-1.96081561693761|43 |23 |0.00506050605060506 |4545 |10287 |RBBP8,RHNO1,RAD9B,RFC2,TOP3A,RMI2,RPA3,CHEK1,RAD51D,RAD51B,DNA2,BRCA1,ATM,XRCC2,EXO1,RFC3,BARD1,RPA2,NBN,TOPBP1,RPA1,ATR,ATRIP R-HSA-74158 |RNA Polymerase III Transcription |0.143153418916263 |-1.94383836427046|41 |22 |0.00484048404840484 |4545 |10287 |POU2F1,SNAPC5,GTF3C6,POLR3GL,POLR2E,ZNF143,POLR3A,GTF3C1,NFIB,CRCP,GTF3C2,NFIX,BDP1,POLR3H,NFIC,POLR3E,POLR3B,POLR1D,NFIA,TBP,BRF1,GTF3A R-HSA-749476 |RNA Polymerase III Abortive And Retractive Initiation |0.143153418916263 |-1.94383836427046|41 |22 |0.00484048404840484 |4545 |10287 |POLR1D,NFIA,TBP,BRF1,GTF3A,BDP1,NFIX,GTF3C2,POLR3H,NFIC,POLR3E,POLR3B,NFIB,CRCP,GTF3C6,POLR3GL,POU2F1,SNAPC5,GTF3C1,POLR2E,ZNF143,POLR3A R-HSA-5620924|Intraflagellar transport |0.143153418916263 |-1.94383836427046|41 |22 |0.00484048404840484 |4545 |10287 |IFT80,KIF3B,IFT52,TRAF3IP1,KIF3C,DYNLRB1,DYNLRB2,KIF17,DYNC2LI1,IFT122,IFT172,WDR60,IFT20,IFT22,IFT43,IFT57,TTC30A,CLUAP1,TNPO1,IFT81,IFT88,TTC21B R-HSA-983695 |Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |0.145563911851131 |-1.92714003210677|39 |21 |0.00462046204620462 |4545 |10287 |PIK3R1,SH3KBP1,CALM2,GRB2,ITPR1,BLNK,ITPR2,PLCG2,AHCYL1,ORAI1,NCK1,MIR4687,SOS1,FYN,CALM1,LYN,CBLB,ITPR3,SHC1,TRPC1,PIK3AP1 R-HSA-140877 |Formation of Fibrin Clot (Clotting Cascade) |0.145563911851131 |-1.92714003210677|39 |21 |0.00462046204620462 |4545 |10287 |SERPIND1,GP1BA,F13A1,SERPINE2,VWF,F2,FGG,PROS1,F7,FGB,TFPI,PRCP,FGA,PROC,F10,A2M,SERPINA5,SERPINC1,F5,F11,KNG1 R-HSA-176187 |Activation of ATR in response to replication stress |0.147964972694265 |-1.91077970421372|37 |20 |0.0044004400440044 |4545 |10287 |RFC3,CDC6,RPA2,MCM4,ATR,MCM3,ORC5,ATRIP,RPA1,MCM5,MCM10,ORC1,RFC2,RAD9B,RPA3,ORC4,CDC7,ORC2,ORC6,CHEK1 R-HSA-176814 |Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |0.151101421196698 |-1.88980400407793|77 |39 |0.00858085808580858 |4545 |10287 |PSMB9,PSMF1,CCNA2,BUB1B,PSMA6,PSMA1,PSMD12,PSMC4,ANAPC4,UBB,PSMB5,UBA52,BUB3,PSMB8,PSMB3,PSMB1,PSMC2,SEM1,PSMB4,UBC,PSMB7,UBE2D1,ANAPC15,PSMD1,PSMA7,PSMA3,PSMB11,PSMD3,PSMB10,PSMD7,NEK2,PSME4,PSMA5,CDC20,PSMD14,ANAPC7,UBE2E1,PLK1,UBE2C R-HSA-4085001|Sialic acid metabolism |0.152684124600157 |-1.87938403679776|33 |18 |0.00396039603960396 |4545 |10287 |ST6GALNAC2,ST3GAL4,NEU1,GLB1,ST6GALNAC4,ST3GAL5,ST3GAL6,GNE,ST3GAL1,NEU4,ST3GAL2,NEU3,ST6GALNAC1,NANS,SLC35A1,ST8SIA2,SLC17A5,ST6GAL1 R-HSA-5654738|Signaling by FGFR2 |0.154286304519737 |-1.86894528233561|75 |38 |0.00836083608360836 |4545 |10287 |SPRY2,SHC1,POLR2E,FGF1,UBC,TIA1,FGFBP3,PTPN11,NRAS,FRS2,POLR2A,MIR6773,RBFOX2,KRAS,GTF2F2,FGF3,GRB2,HNRNPF,HNRNPM,TIAL1,PPP2CA,PTBP1,FRS3,UBB,FGFR2,POLR2D,FGF10,BRAF,FGF9,FGF2,UBA52,SRC,HNRNPH1,SOS1,MAPK1,FGF20,PIK3R1,GTF2F1 R-HSA-180786 |Extension of Telomeres |0.15496502850001 |-1.86455581010008|31 |17 |0.00374037403740374 |4545 |10287 |NHP2,WRAP53,RUVBL1,RPA1,RUVBL2,POLE4,RPA2,RFC3,PRIM2,DNA2,RFC1,POLE3,RPA3,DKC1,RFC2,PCNA,POLD2 R-HSA-8854050|FBXL7 down-regulates AURKA during mitotic entry and in early mitosis |0.155304190478257 |-1.86236956607333|56 |29 |0.00638063806380638 |4545 |10287 |SEM1,PSMC2,PSMB1,PSMB8,PSMD14,PSMB3,SKP1,PSME4,PSMA5,PSMB10,UBA52,PSMD3,PSMD7,PSMB11,UBB,PSMB5,PSMA3,PSMC4,PSMD12,PSMA7,PSMD1,PSMA1,PSMA6,PSMB7,CUL1,PSMB4,UBC,PSMF1,PSMB9 R-HSA-5689603|UCH proteinases |0.156461519518516 |-1.85494518090661|105 |52 |0.0114411441144114 |4545 |10287 |SMAD7,UBC,PSMB4,INO80C,PSMB7,OGT,USP15,HIST1H2AK,PSMD1,PSMA7,HIST1H2AE,PSMA3,INO80,ACTB,ACTR5,ASXL1,PSMB11,PSMD7,HIST1H2AA,PSMB10,PSMD3,RUVBL1,FOXK2,PSMA5,PSME4,HIST2H2AB,MBD6,YY1,PSMD14,PSMB9,PSMF1,KDM1B,PSMA6,PSMA1,FOXK1,PSMC4,PSMD12,PSMB5,UBB,SENP8,ASXL2,UBA52,ADRM1,INO80D,HIST1H2AG,TGFBR2,PSMB3,PSMB8,PSMB1,BARD1,SEM1,PSMC2 R-HSA-5654732|Negative regulation of FGFR3 signaling |0.157159534928483 |-1.85049384351945|29 |16 |0.00352035203520352 |4545 |10287 |FGF9,FRS2,FGF2,FGFR3,BRAF,PTPN11,MAPK1,UBA52,SRC,FGF20,GRB2,PPP2CA,SPRY2,UBC,FGF1,UBB R-HSA-174184 |Cdc20:Phospho-APC/C mediated degradation of Cyclin A |0.157557642307501 |-1.84796390476709|73 |37 |0.00814081408140814 |4545 |10287 |PSMA5,PSME4,CDC20,PSMD7,PSMB10,PSMD3,UBE2E1,UBE2C,ANAPC7,PSMD14,PSMB7,UBE2D1,UBC,PSMB4,PSMA3,PSMB11,ANAPC15,PSMD1,PSMA7,BUB3,UBA52,PSMB1,PSMC2,SEM1,PSMB3,PSMB8,BUB1B,CCNA2,PSMA6,PSMB9,PSMF1,PSMB5,UBB,PSMA1,ANAPC4,PSMD12,PSMC4 R-HSA-5688426|Deubiquitination |0.157987506025929 |-1.84523932486709|301 |142 |0.0312431243124312 |4545 |10287 |STAM,VDAC2,RNF128,ESR1,VDAC1,PSMA1,CCP110,SENP8,ASXL2,RNF123,IL33,NOD2,UBB,SIAH2,USP3,ADRM1,BIRC3,USP28,PSMB8,PSMB4,SMAD3,OGT,ARRB1,TNKS2,TAB1,USP13,OTUD5,USP15,ACTB,RNF135,RAD23B,PSMD7,RUVBL1,PSMD3,HIST2H2AB,ZRANB1,PSME4,HIST1H2BL,SUDS3,MAVS,JOSD1,TNKS,HIF1A,PSMB5,USP14,USP48,HIST1H2AG,INO80D,USP10,UBC,SMAD7,HIST1H2BH,TRAF2,PTRH2,HIST1H2BO,USP22,IKBKG,PSMB11,OTUD7B,EP300,FOXK2,CDC20,MAT2B,BIRC2,YY1,POLB,KAT2B,TRAF3,USP9X,MYSM1,RNF146,PSMD12,FOXK1,MDM4,RAD23A,RCE1,SMAD4,PSMB3,USP5,BRCA1,BARD1,SEM1,PSMB1,INO80C,WDR20,HIST1H2BJ,OTUB1,AXIN1,PSMB7,PSMD1,TNIP1,ASXL1,NFKBIA,NOD1,OTUD7A,PSMA3,HIST1H2AE,RIPK1,INO80,VDAC3,HIST1H2AA,USP47,PSMB10,KEAP1,ABRAXAS1,PSMD14,MDM2,RIPK2,PSMB9,PSMF1,USP4,PSMA6,KDM1B,CCNA2,PSMC4,SMAD1,SMURF2,HIST1H2BC,UBA52,USP34,USP25,TGFBR2,USP2,PSMC2,USP18,OTUB2,UIMC1,ATXN7,UBE2D1,AXIN2,PSMA7,HIST1H2AK,RHOA,DDX58,TRIM25,USP7,ACTR5,MBD6,USP49,PSMA5,USP11,SKP2 R-HSA-1638091|Heparan sulfate/heparin (HS-GAG) metabolism |0.158514366381967 |-1.84191005013846|54 |28 |0.00616061606160616 |4545 |10287 |SLC35D2,HS6ST1,B3GAT3,VCAN,GPC3,GLCE,HS3ST2,HS3ST5,HS3ST6,GPC1,GPC5,HS2ST1,SDC4,B3GALT6,XYLT2,SDC2,EXT1,SDC3,NAGLU,GUSB,NDST1,GLB1,GPC6,NDST2,HSPG2,GPC4,B3GAT2,SDC1 R-HSA-901042 |Calnexin/calreticulin cycle |0.15923244934832 |-1.83739019877705|27 |15 |0.0033003300330033 |4545 |10287 |SYVN1,RNF185,SEL1L,UBC,RNF103,EDEM1,OS9,UBA52,MARCH6,EDEM2,AMFR,UBB,UGGT1,RNF139,CANX R-HSA-380994 |ATF4 activates genes |0.15923244934832 |-1.83739019877705|27 |15 |0.0033003300330033 |4545 |10287 |NFYC,EXOSC3,ATF4,CXCL8,DCP2,PARN,ATF6,EXOSC9,ATF3,HERPUD1,NFYA,ASNS,DIS3,DDIT3,IGFBP1 R-HSA-6783589|Interleukin-6 family signaling |0.15923244934832 |-1.83739019877705|27 |15 |0.0033003300330033 |4545 |10287 |OSMR,STAT3,OSM,JAK2,TYK2,SOCS3,LIFR,JAK1,IL6R,IL12A,IL27,CLCF1,PTPN11,STAT1,IL6ST R-HSA-198725 |Nuclear Events (kinase and transcription factor activation) |0.161137340335246 |-1.82549823207372|25 |14 |0.00308030803080308 |4545 |10287 |PPP2CA,PPP2R1B,RPS6KA3,RPS6KA2,MEF2A,DUSP3,CREB1,DUSP7,MAPKAPK2,MAPK1,RPS6KA1,ATF1,DUSP6,MAPK14 R-HSA-5654700|FRS-mediated FGFR2 signaling |0.161137340335246 |-1.82549823207372|25 |14 |0.00308030803080308 |4545 |10287 |FRS3,FGF1,SOS1,PTPN11,NRAS,FRS2,FGF9,FGF2,FGF3,FGF10,GRB2,KRAS,FGFR2,FGF20 R-HSA-5654708|Downstream signaling of activated FGFR3 |0.161137340335246 |-1.82549823207372|25 |14 |0.00308030803080308 |4545 |10287 |KRAS,FGF20,PIK3R1,GRB2,NRAS,PTPN11,FGFR3,FGF2,FGF9,FRS2,FGF1,SOS1,SHC1,FRS3 R-HSA-5696397|Gap-filling DNA repair synthesis and ligation in GG-NER |0.161137340335246 |-1.82549823207372|25 |14 |0.00308030803080308 |4545 |10287 |POLD2,LIG3,RFC3,PCNA,RFC2,UBB,RPA3,RPA2,POLE4,UBC,RPA1,RFC1,UBA52,POLE3 R-HSA-5673000|RAF activation |0.161137340335246 |-1.82549823207372|25 |14 |0.00308030803080308 |4545 |10287 |BRAF,NRAS,BRAP,PPP2CA,PPP2R1B,MARK3,SRC,RAF1,KRAS,MAP2K1,PPP2R5A,JAK2,KSR1,YWHAB R-HSA-211981 |Xenobiotics |0.161137340335246 |-1.82549823207372|25 |14 |0.00308030803080308 |4545 |10287 |CYP2C8,CYP3A4,CYP2C18,CYP1A1,CYP2B6,CYP2C9,CYP2J2,AHR,CYP2A6,ARNT,CYP3A7-CYP3A51P,CYP2W1,CYP2S1,CYP3A43 R-HSA-5205685|Pink/Parkin Mediated Mitophagy |0.162812099401212 |-1.81515850752907|23 |13 |0.00286028602860286 |4545 |10287 |PINK1,UBA52,UBC,TOMM5,VDAC1,TOMM6,MAP1LC3B,ATG5,SQSTM1,MFN2,MAP1LC3A,UBB,TOMM40 R-HSA-5205647|Mitophagy |0.162812099401212 |-1.81515850752907|23 |13 |0.00286028602860286 |4545 |10287 |MFN2,SQSTM1,ATG5,MAP1LC3B,TOMM40,UBB,MAP1LC3A,TOMM5,UBC,UBA52,PINK1,TOMM6,VDAC1 R-HSA-2453902|The canonical retinoid cycle in rods (twilight vision) |0.162812099401212 |-1.81515850752907|23 |13 |0.00286028602860286 |4545 |10287 |SDR9C7,RDH10,HSD17B6,HSD17B1,RLBP1,MYO7A,RHO,RBP4,RDH16,STRA6,RDH12,ABCA4,RDH11 R-HSA-5576891|Cardiac conduction |0.16341351098656 |-1.81147141339833|142 |69 |0.0151815181518152 |4545 |10287 |KCNK16,CACNG1,ATP2A2,ATP1B3,ORAI1,KCNE4,KCNK9,ATP1A1,KCNK5,CAMK2B,ITPR2,FKBP1B,SCN9A,TRPC1,FXYD1,ITPR3,KCNJ2,HIPK1,HIPK2,ATP2B1,SCN8A,MIR4687,CACNA1D,ATP2B4,KCNK17,CALM2,CACNG4,FXYD2,KCNK15,KCNJ4,KCNK12,SCN1A,NOS1,KCNE3,SCN5A,ATP1A2,CACNA2D3,FGF14,SCN4A,AKAP9,CAMK2G,SLC8A3,KCNK3,SRI,CAMK2A,KAT2B,KCNK13,CACNG6,SCN7A,GATA4,CACNB3,ATP2A1,KCNIP4,CACNB4,PRKACA,NKX2-5,AHCYL1,KCNQ1,ITPR1,ATP2B3,CAMK2D,SCN2B,KCNK10,CACNA2D4,KCNK2,WWTR1,ATP2B2,ATP1B1,CALM1 R-HSA-5654689|PI-3K cascade:FGFR1 |0.164172260483865 |-1.80683903360522|21 |12 |0.00264026402640264 |4545 |10287 |FGF1,PTPN11,FGF2,KL,FGF9,FRS2,FGF3,FGFR1,PIK3R1,FGF10,GRB2,FGF20 R-HSA-6807004|Negative regulation of MET activity |0.164172260483865 |-1.80683903360522|21 |12 |0.00264026402640264 |4545 |10287 |PTPN2,UBC,PTPRJ,STAM,EPS15,UBA52,PTPN1,GRB2,SH3KBP1,LRIG1,SH3GL1,UBB R-HSA-204005 |COPII (Coat Protein 2) Mediated Vesicle Transport |0.16437407309636 |-1.80561051502352|69 |35 |0.0077007700770077 |4545 |10287 |SEC23IP,TRAPPC6A,PPP6R3,LMAN1,SEC22B,GOSR2,NAPG,USO1,SEC13,CTSC,FOLR1,SAR1B,TRAPPC10,SEC24A,TMED10,SEC16A,TRAPPC5,F5,RAB1A,SEC23A,NAPA,AREG,TGFA,SERPINA1,SCFD1,LMAN2L,CNIH1,TRAPPC6B,TBC1D20,PPP6C,MCFD2,PPP6R1,CTSZ,NAPB,SEC24D R-HSA-3560801|Defective B3GAT3 causes JDSSDHD |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |GPC3,VCAN,GPC6,SDC3,SDC2,SDC4,SDC1,GPC4,GPC5,GPC1,HSPG2 R-HSA-4420332|Defective B3GALT6 causes EDSP2 and SEMDJL1 |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |GPC3,VCAN,GPC6,SDC2,SDC3,GPC4,GPC5,SDC1,SDC4,HSPG2,GPC1 R-HSA-442982 |Ras activation uopn Ca2+ infux through NMDA receptor |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |CAMK2D,CALM1,CALM2,RASGRF1,CAMK2G,CAMK2B,GRIN2A,AKAP9,RASGRF2,NEFL,CAMK2A R-HSA-5223345|Miscellaneous transport and binding events |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |CTNS,NIPAL2,SLC66A1,ADD1,DMTN,NIPAL3,TUSC3,NIPA2,ANKH,NIPAL1,ADD3 R-HSA-156584 |Cytosolic sulfonation of small molecules |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |ABHD14B,SULT1C2,SULT1A1,SLC26A1,SULT1E1,SULT2B1,SULT1A2,PAPSS2,SULT1B1,PAPSS1,SULT2A1 R-HSA-3560783|Defective B4GALT7 causes EDS, progeroid type |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |HSPG2,GPC1,GPC5,GPC4,SDC1,SDC4,SDC2,SDC3,GPC6,VCAN,GPC3 R-HSA-888590 |GABA synthesis, release, reuptake and degradation |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |STX1A,DNAJC5,HSPA8,STXBP1,SLC6A1,SLC6A12,VAMP2,CPLX1,SLC6A11,ABAT,ALDH5A1 R-HSA-8876725|Protein methylation |0.165100643024191 |-1.80120003330779|19 |11 |0.00242024202420242 |4545 |10287 |CALM2,CAMKMT,CALM1,PRMT3,ETFB,EEF2,HSPA8,EEF2KMT,EEF1A1,EEF1AKMT1,METTL21A R-HSA-73893 |DNA Damage Bypass |0.165176015162923 |-1.80074361510098|50 |26 |0.00572057205720572 |4545 |10287 |RFC2,TRIM25,PCNA,RPA3,UBB,POLD2,ISG15,USP43,REV1,UBC,POLI,RFC1,POLE3,RFC3,USP1,RPA2,USP10,SPRTN,RAD18,UBE2B,RPA1,NPLOC4,DTL,POLE4,CUL4B,UBA52 R-HSA-1660499|Synthesis of PIPs at the plasma membrane |0.165176015162923 |-1.80074361510098|50 |26 |0.00572057205720572 |4545 |10287 |PLEKHA6,PIP5K1B,MTMR14,PIK3CB,PIP4K2A,PIK3R1,PI4K2A,PIK3CG,PIK3R2,PIK3R5,PIK3C2A,MTMR3,PIK3C2B,INPP4A,RAB4A,RUFY1,INPP5D,PIP5K1A,PIK3C2G,SYNJ2,OCRL,PLEKHA2,MTM1,RAB14,PIK3R3,ARF1 R-HSA-5663205|Infectious disease |0.172123681751885 |-1.75954198062998|388 |181 |0.0398239823982398 |4545 |10287 |RPL9,GUCY2C,RPS9,NUP188,RPS19,RPS20,NUP210,ELMO1,BTRC,MAP2K7,FYN,PSMB8,RPL13A,RANBP2,RANGAP1,RPL38,RNMT,STAM,RPS4Y2,TAF3,RPS16,PSMA1,STX1B,POLR2D,UBB,RPL34,CD247,HBEGF,PSMD3,PSMD7,POLR2A,PSME4,TAF12,RPS3A,GRB2,SH3KBP1,SH3GL1,MAP2K1,RPS13,RPS15A,PSMB4,SUPT4H1,CD9,SEH1L,XRCC5,NUP93,CHMP4B,CXCR4,CALM1,GTF2B,RPL24,SLC25A4,RPL26,HSP90AA1,TAF6,AP1M1,PPIA,GTF2F1,VPS4A,PACS1,AP2A2,ANTXR2,CHMP2A,RAE1,ARF1,AP2S1,MIR6805,RPL18A,NUP205,PSMB5,AP1S3,RPS24,NUP42,NMT1,CALM2,NUP214,NUP35,RPL13,GTF2F2,RPL36,LIG4,POLR2E,UBC,DNAJC3,VPS4B,FURIN,PSMB11,NUP58,TXNRD1,RPL15,KPNA7,SRC,VPS37B,KPNA1,SKP1,PABPN1,KPNA3,AP2B1,MAP2K3,PSMB3,ELOC,SEM1,CHMP6,PSMB1,RPL23,PSMD12,NUP85,NEDD4L,RPL32,CCNH,VAMP2,XPO1,CCNT2,RAN,PSMB10,IPO5,MIR1257,PDCD6IP,PSMD14,ANTXR1,CHMP2B,TAF11,TBP,RPL19,NUP43,ELL,KPNB1,CHMP4C,EPS15,ISG15,TAF1,PSMB7,CTNNB1,HSP90AB1,PSMD1,CPSF4,CD28,RPS5,KPNA2,PSMA3,GTF2A1,UBA52,MAP2K6,RPLP1,PSMC2,PSMB9,PSMF1,AP1S2,NELFE,RPS15,NELFA,PSMA6,RPLP2,TAF4,PSMC4,XRCC6,EEF2,VAMP1,RPL22L1,RPL5,PSMA5,STX1A,RPL12,CHMP4A,PAK2,HSPA1A,RPL21,RPS21,RPL23A,CHMP3,NELFCD,CDH1,RPS11,PSMA7,RPL10A,CANX,AP2M1,AP2A1,RPL31,RPS27,ELOA R-HSA-5668914|Diseases of metabolism |0.175803827714084 |-1.73838652085044|44 |23 |0.00506050605060506 |4545 |10287 |UBA52,MMADHC,SFTPA1,MTR,FDX1,GYS2,PCCB,IDH1,MTRR,FDXR,ACACA,PPP1R3C,AMN,MMAA,POMC,UBC,MMACHC,MC2R,UBB,GYG1,CCDC59,GYS1,EPM2A R-HSA-162909 |Host Interactions of HIV factors |0.176768349523787 |-1.73291516333494|134 |65 |0.0143014301430143 |4545 |10287 |PSMA7,AP2M1,AP2A1,NUP58,PSMB11,UBC,NUP214,NUP35,PAK2,AP1S3,NUP42,PSMA5,PSMC4,PSMB5,NUP205,PSMB9,PSMF1,ARF1,AP1S2,PSMA6,AP2S1,AP2A2,PACS1,PSMC2,RAE1,UBA52,SLC25A4,AP1M1,PPIA,PSMD1,NUP93,CD28,PSMA3,PSMB4,NUP43,KPNB1,SEH1L,PSMB7,PSMD14,RAN,CD247,PSMD7,PSMD3,PSMB10,PSME4,NUP85,PSMD12,PSMA1,XPO1,UBB,PSMB3,AP2B1,PSMB8,ELOC,RANBP2,RANGAP1,SEM1,PSMB1,ELMO1,SKP1,BTRC,NUP188,KPNA1,NUP210,FYN R-HSA-446193 |Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|0.177555754613285 |-1.72847060889166|78 |39 |0.00858085808580858 |4545 |10287 |ST6GAL1,SLC35C1,SLC17A5,GMPPB,NUS1,UAP1,GFPT1,ALG13,NEU3,ALG2,GNE,DOLPP1,RFT1,ST3GAL1,NEU4,ALG8,PMM1,ST3GAL6,NEU1,ALG10,FCSK,ST8SIA2,GNPNAT1,SLC35A1,GFPT2,PGM3,DOLK,NANS,ST6GALNAC1,TSTA3,ST3GAL2,GMDS,DPM1,ALG9,ST3GAL5,ST6GALNAC2,ST6GALNAC4,GLB1,ST3GAL4 R-HSA-1566948|Elastic fibre formation |0.179523668867059 |-1.71744821976295|42 |22 |0.00484048404840484 |4545 |10287 |MFAP4,LTBP2,LOXL2,TGFB3,VTN,LOX,MFAP1,LOXL4,BMP10,LOXL1,FBN1,ITGB3,ITGB5,LINC02478,BMP4,FBLN5,FURIN,LTBP1,FBLN1,FBN3,ITGB1,LTBP4 R-HSA-176409 |APC/C:Cdc20 mediated degradation of mitotic proteins |0.181454929087635 |-1.70674798070092|76 |38 |0.00836083608360836 |4545 |10287 |PSMF1,PSMB9,BUB1B,CCNA2,PSMA6,PSMA1,ANAPC4,PSMD12,PSMC4,PSMB5,UBB,UBA52,BUB3,PSMB3,PSMB8,PSMB1,PSMC2,SEM1,UBC,PSMB4,PSMB7,UBE2D1,PSMA7,ANAPC15,PSMD1,PSMA3,PSMB11,PSMD7,PSMB10,PSMD3,PSMA5,PSME4,NEK2,CDC20,ANAPC7,PSMD14,UBE2E1,UBE2C R-HSA-109703 |PKB-mediated events |0.183334737089008 |-1.69644163260391|40 |21 |0.00462046204620462 |4545 |10287 |MTOR,PRKAA1,EIF4EBP1,PRKAB2,TSC2,PRKAG2,PRKAG1,YWHAB,CAB39,PDE3B,RRAGB,RPTOR,RRAGC,LAMTOR4,AKT1S1,STRADA,PRKAB1,EIF4B,EEF2K,RHEB,EIF4E R-HSA-168276 |NS1 Mediated Effects on Host Pathways |0.183334737089008 |-1.69644163260391|40 |21 |0.00462046204620462 |4545 |10287 |NUP35,NUP214,RAE1,RANBP2,NUP42,KPNA7,KPNA3,PABPN1,NUP188,NUP210,KPNA1,CPSF4,NUP85,NUP93,NUP205,NUP58,KPNA2,NUP43,KPNB1,SEH1L,ISG15 R-HSA-390471 |Association of TriC/CCT with target proteins during biosynthesis |0.183334737089008 |-1.69644163260391|40 |21 |0.00462046204620462 |4545 |10287 |CCNE1,DCAF7,CCT2,KIFC3,CCT3,FBXL3,WRAP53,FBXO6,FBXW5,ARFGEF2,USP11,FBXO4,CCT5,FKBP9,SPHK1,LONP2,FBXW2,STAT3,KIF13A,XRN2,GBA R-HSA-5419276|Mitochondrial translation termination |0.18906074774751 |-1.66568689891227|87 |43 |0.00946094609460946 |4545 |10287 |MRPL14,MRPL44,MRPS25,MRPS9,MRPS33,MRPL1,MRPS10,MRPS5,MRPL22,MRPS16,MRPS21,MRPS28,MRPS36,CHCHD1,MRPL13,MRPL46,MRPL55,MRPL16,GFM2,MRPL35,MRPL3,MRPS18B,MRPS17,MRPL30,MRPL15,MRPL53,MRPL48,MRPS18A,MRPS15,MRPS23,MRPS27,MRPL54,MRPL18,MRPL34,MRPS14,MRPL33,MRPL4,PTCD3,MRPL10,MRPL19,MRPL17,MRPL2,MRPS35 R-HSA-69202 |Cyclin E associated events during G1/S transition |0.189604027910067 |-1.66281744513546|72 |36 |0.00792079207920792 |4545 |10287 |PSMB1,SEM1,PSMC2,CDKN1A,PSMB8,PSMB3,SKP1,UBA52,CDK4,CCND1,UBB,PSMB5,CCNH,PSMA1,PSMC4,PSMD12,CCNA2,PSMA6,PSMF1,PSMB9,AKT3,PSMD14,SKP2,PSMA5,PSMD3,PSMB10,PSMD7,PSMA3,PSMA7,PSMD1,PSMB7,WEE1,PSMB4,CUL1,UBC,CCNE1 R-HSA-167021 |PLC-gamma1 signalling |0.191233724257333 |-1.65425891181931|36 |19 |0.00418041804180418 |4545 |10287 |ADCY3,ITPR3,CREB1,CAMK4,PRKCA,CALM1,ADCY9,PRKCD,PRKCE,AHCYL1,PRKAR1A,PRKACA,ADCY8,CALM2,ITPR1,ADCY7,ADCY4,ADCY1,ITPR2 R-HSA-180585 |Vif-mediated degradation of APOBEC3G |0.19156271722247 |-1.65254001890134|55 |28 |0.00616061606160616 |4545 |10287 |PSMB3,PSMD14,PSMB8,ELOC,PSMC2,SEM1,PSMB1,PSMD7,UBA52,PSMD3,PSMB10,PSMA5,PSME4,PSMA7,PSMD1,PSMD12,PSMC4,PSMA1,PSMB11,PSMB5,PSMA3,UBB,UBC,PSMB4,PSMB9,PSMF1,PSMA6,PSMB7 R-HSA-5693607|Processing of DNA double-strand break ends |0.194999897601168 |-1.63475624554075|98 |48 |0.0105610561056106 |4545 |10287 |HIST1H4H,ABRAXAS1,HIST1H2BL,UBE2I,ATR,SUMO2,ATRIP,HIST1H4K,RPA1,NBN,TOP3A,HIST1H4B,HIST1H2BO,HIST1H4I,HIST1H2BH,DNA2,PPP4C,UBC,UIMC1,UBE2V2,HIST1H2BJ,NSD2,BARD1,PPP4R2,RFC3,EXO1,RPA2,HIST1H4D,BRCA1,UBE2N,ATM,MDC1,TP53BP1,TOPBP1,UBA52,HIST1H2BC,RFC2,RMI2,RAD9B,RHNO1,RPA3,UBB,RBBP8,HIST1H4E,TIMELESS,RNF8,CCNA2,CHEK1 R-HSA-5654727|Negative regulation of FGFR2 signaling |0.195321296365206 |-1.63310940267571|34 |18 |0.00396039603960396 |4545 |10287 |FGF3,GRB2,FGF20,SRC,UBA52,MAPK1,PTPN11,BRAF,FGF2,FGF9,FRS2,FGF10,UBB,FGFR2,UBC,FGF1,SPRY2,PPP2CA R-HSA-195253 |Degradation of beta-catenin by the destruction complex |0.197465219720884 |-1.62219281282793|83 |41 |0.00902090209020902 |4545 |10287 |PSMB1,PSMC2,SEM1,PSMB8,PSMB3,PPP2R1B,BTRC,SKP1,UBA52,UBB,PSMB5,TLE1,PSMA1,PSMC4,PSMD12,PSMA6,PPP2CA,PSMF1,PSMB9,FRAT2,PPP2R5A,PSMD14,PSME4,PSMA5,PSMD3,PSMB10,PSMD7,TCF7,PSMA3,PSMB11,GSK3B,PSMD1,PSMA7,CTNNB1,PSMB7,AXIN1,TCF7L2,TLE3,PSMB4,CUL1,UBC R-HSA-174154 |APC/C:Cdc20 mediated degradation of Securin |0.198258621862421 |-1.61818292956456|68 |34 |0.00748074807480748 |4545 |10287 |ANAPC7,PSMD14,UBE2C,UBE2E1,PSMD7,PSMD3,PSMB10,CDC20,PSMA5,PSME4,ANAPC15,PSMD1,PSMA7,PSMB11,PSMA3,UBC,PSMB4,UBE2D1,PSMB7,PSMB3,PSMB8,SEM1,PSMC2,PSMB1,UBA52,PSMD12,PSMC4,ANAPC4,PSMA1,PSMB5,UBB,PSMF1,PSMB9,PSMA6 R-HSA-399721 |Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity |0.19949872565976 |-1.611947430343 |32 |17 |0.00374037403740374 |4545 |10287 |AP2B1,TSPAN7,CACNG4,AP2A2,MDM2,CAMK2D,CAMK2B,CAMK2G,GRIP2,GRIA3,CAMK2A,PRKCA,AP2S1,PICK1,AP2A1,AP2M1,DLG1 R-HSA-399719 |Trafficking of AMPA receptors |0.19949872565976 |-1.611947430343 |32 |17 |0.00374037403740374 |4545 |10287 |TSPAN7,CACNG4,CAMK2D,AP2A2,MDM2,AP2B1,GRIP2,CAMK2B,CAMK2G,PICK1,DLG1,AP2A1,AP2M1,CAMK2A,PRKCA,AP2S1,GRIA3 R-HSA-73886 |Chromosome Maintenance |0.199678379264096 |-1.6110473105002 |109 |53 |0.0116611661166117 |4545 |10287 |RFC2,PCNA,RPA3,CENPA,CENPX,HIST1H4E,CENPW,MIS18A,RFC1,POLE3,MIS18BP1,RFC3,RPA2,HIST1H4D,TERF2,CENPS,NHP2,POLE4,H2AFV,H2AFZ,POT1,HIST1H2BC,DKC1,HIST1H2AE,KNL1,HIST1H4B,HIST1H2BO,POLD2,HIST1H4I,SMARCA5,HIST1H2BH,CENPU,TINF2,CENPT,DNA2,CENPL,ACD,HJURP,HIST1H2BJ,HIST1H4H,HIST1H2BL,CENPC,OIP5,PRIM2,CENPH,ITGB3BP,HIST1H4K,RPA1,RBBP7,H2AFJ,RUVBL2,WRAP53,RUVBL1 R-HSA-112310 |Neurotransmitter Release Cycle |0.200461687609907 |-1.6071321347343 |51 |26 |0.00572057205720572 |4545 |10287 |SLC1A2,PPFIA3,DNAJC5,ALDH5A1,NAAA,ABAT,GLS2,CPLX1,VAMP2,SLC6A12,SLC6A1,APBA1,SLC22A2,STXBP1,GLS,HSPA8,PPFIA1,STX1A,CASK,LIN7A,SLC1A3,SLC1A7,SLC6A11,MAOA,SLC38A2,SYN3 R-HSA-5368287|Mitochondrial translation |0.20350737609348 |-1.59205302859676|94 |46 |0.0101210121012101 |4545 |10287 |MTIF2,MRPS5,MRPL22,MRPS16,MRPS21,MRPL13,MRPS28,CHCHD1,MRPS36,MRPL55,MRPL46,MRPL16,GFM2,MRPL3,MRPS18B,MRPS17,MRPL35,MRPL14,MTIF3,MRPL44,MRPS9,MRPS25,MRPL1,MRPS33,MRPS10,MRPS27,MRPL54,MRPL34,MRPL18,MRPL33,MRPS14,TSFM,MRPL4,MRPL19,MRPL17,MRPL10,PTCD3,MRPS35,MRPL2,MRPL30,MRPL15,MRPL53,MRPS15,MRPL48,MRPS18A,MRPS23 R-HSA-1912408|Pre-NOTCH Transcription and Translation |0.203762127986522 |-1.59080200477241|30 |16 |0.00352035203520352 |4545 |10287 |TNRC6C,EP300,CCND1,TFDP2,CREBBP,RBPJ,TNRC6B,AGO3,NOTCH3,KAT2B,TNRC6A,AGO2,NOTCH1,E2F3,MAML1,JUN R-HSA-5654696|Downstream signaling of activated FGFR2 |0.203762127986522 |-1.59080200477241|30 |16 |0.00352035203520352 |4545 |10287 |FGF1,FRS3,SHC1,FGFR2,FGF10,FGF2,FGF9,FRS2,PTPN11,NRAS,SOS1,FGF20,KRAS,GRB2,FGF3,PIK3R1 R-HSA-917977 |Transferrin endocytosis and recycling |0.203762127986522 |-1.59080200477241|30 |16 |0.00352035203520352 |4545 |10287 |ATP6V0E1,ATP6V1D,ATP6V0D2,STEAP3,ATP6V1G2,TF,ATP6V0D1,ATP6V1E2,ATP6V0A1,ATP6V1C2,ATP6V1C1,ATP6V0C,ATP6V1G1,ATP6V0A4,MCOLN1,TFRC R-HSA-2871809|FCERI mediated Ca+2 mobilization |0.203762127986522 |-1.59080200477241|30 |16 |0.00352035203520352 |4545 |10287 |ITPR1,CALM2,GRB2,PLCG2,ITPR2,PPP3CA,SOS1,AHCYL1,CALM1,LYN,SHC1,ITPR3,NFATC2,NFATC3,VAV3,VAV2 R-HSA-8863795|Downregulation of ERBB2 signaling |0.203762127986522 |-1.59080200477241|30 |16 |0.00352035203520352 |4545 |10287 |EGF,NRG4,AKT3,UBA52,HSP90AA1,BTC,HBEGF,ERBB2,PTPN18,ERBB3,NRG1,ERBIN,UBB,RNF41,UBC,PTPN12 R-HSA-174084 |Autodegradation of Cdh1 by Cdh1:APC/C |0.207470556021961 |-1.5727658480693 |64 |32 |0.00704070407040704 |4545 |10287 |PSMD12,ANAPC4,PSMC4,PSMA1,PSMB5,UBB,PSMB9,PSMF1,PSMA6,PSMB3,PSMB8,SEM1,PSMC2,PSMB1,UBA52,PSMA7,PSMD1,ANAPC15,PSMA3,UBC,PSMB4,UBE2D1,PSMB7,ANAPC7,PSMD14,FZR1,UBE2C,UBE2E1,PSMD7,PSMD3,PSMB10,PSMA5 R-HSA-75876 |Synthesis of very long-chain fatty acyl-CoAs |0.208104892274504 |-1.56971303661091|28 |15 |0.0033003300330033 |4545 |10287 |ACSF3,ACSL1,HACD2,TECR,ACSL3,ELOVL5,ACSL6,ACSL4,MIR639,ELOVL3,ACSBG2,HACD1,ACSL5,ELOVL6,ACSBG1 R-HSA-76061 |RNA Polymerase III Transcription Initiation From Type 1 Promoter |0.208104892274504 |-1.56971303661091|28 |15 |0.0033003300330033 |4545 |10287 |BRF1,POLR1D,TBP,GTF3A,CRCP,GTF3C2,POLR3GL,BDP1,GTF3C6,POLR3B,POLR3H,POLR2E,POLR3E,POLR3A,GTF3C1 R-HSA-211976 |Endogenous sterols |0.208104892274504 |-1.56971303661091|28 |15 |0.0033003300330033 |4545 |10287 |NCOA1,CYP11B2,CYP51A1,POMC,AHR,CYP8B1,FDX1,RXRA,NR1H4,PTGIS,CYP19A1,CYP27A1,FDXR,ARNT,NCOA2 R-HSA-5357769|Caspase activation via extrinsic apoptotic signalling pathway |0.208104892274504 |-1.56971303661091|28 |15 |0.0033003300330033 |4545 |10287 |DAPK2,UNC5A,TNFSF10,LY96,CD14,RIPK1,FASLG,CFLAR,DCC,TNFRSF10B,CASP8,CASP9,DAPK1,TRAF2,FAS R-HSA-379716 |Cytosolic tRNA aminoacylation |0.212516463486638 |-1.54873581838748|26 |14 |0.00308030803080308 |4545 |10287 |CARS,NARS,AIMP1,EEF1E1,TARS,LARS,WARS,MARS,IARS,EPRS,AIMP2,FARSB,GARS,SARS R-HSA-379724 |tRNA Aminoacylation |0.21496807061887 |-1.53726577063243|45 |23 |0.00506050605060506 |4545 |10287 |IARS,RARS2,NARS,MARS2,NARS2,PARS2,TARS,EARS2,SARS,AARS2,WARS,LARS,EPRS,MARS,AIMP1,PPA2,CARS,EEF1E1,GARS,TARS2,LARS2,AIMP2,FARSB R-HSA-8854214|TBC/RABGAPs |0.21496807061887 |-1.53726577063243|45 |23 |0.00506050605060506 |4545 |10287 |TBC1D25,MAP1LC3B,RAB5B,RAB35,TBC1D24,TBC1D14,RAB7A,ARF6,TBC1D20,TBC1D7,RAB6A,RAB4A,RABGAP1,RAB8B,GABARAPL2,RAB33B,TBC1D16,TBC1D13,TSC2,SYTL1,RAB11A,RAB5C,RABGEF1 R-HSA-110373 |Resolution of AP sites via the multiple-nucleotide patch replacement pathway |0.216980506631001 |-1.52794776067028|24 |13 |0.00286028602860286 |4545 |10287 |PARP1,RPA1,POLB,POLE4,POLE3,RFC1,RFC2,RFC3,PCNA,RPA2,RPA3,POLD2,PARP2 R-HSA-5389840|Mitochondrial translation elongation |0.217190351846012 |-1.52698111250745|88 |43 |0.00946094609460946 |4545 |10287 |MRPL13,CHCHD1,MRPS28,MRPS36,MRPS21,MRPS16,MRPL22,MRPS5,MRPS17,MRPS18B,MRPL3,MRPL35,MRPL16,MRPL46,MRPL55,MRPL44,MRPL14,MRPS10,MRPL1,MRPS33,MRPS25,MRPS9,MRPL33,MRPS14,MRPL34,MRPL18,MRPS27,MRPL54,MRPL2,MRPS35,MRPL17,MRPL10,MRPL19,PTCD3,TSFM,MRPL4,MRPL53,MRPL15,MRPL30,MRPS23,MRPS15,MRPL48,MRPS18A R-HSA-5696395|Formation of Incision Complex in GG-NER |0.220150427324728 |-1.51344420572058|43 |22 |0.00484048404840484 |4545 |10287 |UBE2I,UBE2N,RPA2,CUL4B,UBA52,RAD23B,RPA1,SUMO2,CCNH,PARP2,PIAS1,CETN2,RPA3,RAD23A,UBB,ERCC5,SUMO3,ERCC4,UBE2V2,UBC,XPA,PARP1 R-HSA-2173782|Binding and Uptake of Ligands by Scavenger Receptors |0.220150427324728 |-1.51344420572058|43 |22 |0.00484048404840484 |4545 |10287 |SCARB1,HSPH1,HSP90AA1,APOB,APOA1,LRP1,AMBP,STAB2,HYOU1,COLEC11,MSR1,CD36,FTL,HPX,ALB,HPR,HP,STAB1,SAA1,SPARC,FTH1,SCARA5 R-HSA-3769402|Deactivation of the beta-catenin transactivating complex |0.220150427324728 |-1.51344420572058|43 |22 |0.00484048404840484 |4545 |10287 |SOX9,XPO1,TLE1,UBB,TCF7,UBC,TLE3,CHD8,TCF7L2,SOX6,CTNNB1,SRY,RBBP5,SOX13,PYGO2,ASH2L,BCL9L,UBA52,BTRC,YWHAZ,XIAP,MIR6073 R-HSA-157118 |Signaling by NOTCH |0.220756171968163 |-1.51069648080324|112 |54 |0.0118811881188119 |4545 |10287 |UBA52,TFDP2,ATP2A2,CCND1,NCOR2,SKP1,TNRC6B,ADAM17,CREBBP,MIB1,TNRC6A,AGO2,NUMB,CREB1,KAT2B,DTX4,HDAC11,HIF1A,HDAC2,JUN,E2F3,ATP2A1,MIR1825,NOTCH1,UBB,TLE1,ST3GAL4,CDK8,NEURL1B,EP300,ITCH,TNRC6C,HDAC8,TBL1X,DLK1,RBPJ,CUL1,MFNG,UBC,JAG1,SEL1L,HEYL,ARRB1,NOTCH3,HDAC5,AGO3,FURIN,NCSTN,TLE3,HES1,MAML1,HDAC4,ST3GAL6,RAB6A R-HSA-166208 |mTORC1-mediated signalling |0.221472069758617 |-1.5074587933456 |22 |12 |0.00264026402640264 |4545 |10287 |EIF4B,LAMTOR4,YWHAB,AKT1S1,RHEB,EIF4E,EEF2K,EIF4EBP1,RRAGB,MTOR,RRAGC,RPTOR R-HSA-389513 |CTLA4 inhibitory signaling |0.221472069758617 |-1.5074587933456 |22 |12 |0.00264026402640264 |4545 |10287 |YES1,SRC,CTLA4,CD80,PTPN11,FYN,PPP2R1B,PPP2CA,PDPK1,LYN,AKT3,PPP2R5A R-HSA-936837 |Ion transport by P-type ATPases |0.222469617221994 |-1.50296473851115|58 |29 |0.00638063806380638 |4545 |10287 |ATP9A,FXYD2,CAMK2D,ATP2B3,CALM2,ATP1A1,CAMK2G,CAMK2B,ATP2B4,ATP1B3,ATP2A2,ATP11A,ATP11B,ATP10B,ATP1B1,CALM1,ATP2C1,ATP1A2,ATP2A1,ATP2B2,ATP2B1,ATP7B,ATP9B,ATP2C2,FXYD1,CAMK2A,ATP8B1,SRI,ATP8A2 R-HSA-110313 |Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |0.225525121165716 |-1.48932372417889|41 |21 |0.00462046204620462 |4545 |10287 |SPRTN,RFC3,USP10,RPA2,POLE4,NPLOC4,RPA1,UBA52,POLD2,TRIM25,PCNA,RFC2,UBB,RPA3,POLI,UBC,POLE3,RFC1,USP43,ISG15,REV1 R-HSA-1236382|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |0.225953074445189 |-1.4874279364673 |20 |11 |0.00242024202420242 |4545 |10287 |SHC1,UBC,SOS1,HSP90AA1,UBA52,NRAS,GRB2,PIK3R1,EGF,UBB,KRAS R-HSA-1643713|Signaling by EGFR in Cancer |0.225953074445189 |-1.4874279364673 |20 |11 |0.00242024202420242 |4545 |10287 |NRAS,SOS1,UBC,SHC1,UBA52,HSP90AA1,KRAS,UBB,GRB2,EGF,PIK3R1 R-HSA-5637815|Signaling by Ligand-Responsive EGFR Variants in Cancer |0.225953074445189 |-1.4874279364673 |20 |11 |0.00242024202420242 |4545 |10287 |GRB2,EGF,PIK3R1,KRAS,UBB,UBC,SOS1,SHC1,UBA52,HSP90AA1,NRAS R-HSA-8876384|Listeria monocytogenes entry into host cells |0.225953074445189 |-1.4874279364673 |20 |11 |0.00242024202420242 |4545 |10287 |UBA52,CDH1,SRC,EPS15,STAM,UBC,CTNNB1,SH3KBP1,GRB2,UBB,SH3GL1 R-HSA-5654720|PI-3K cascade:FGFR4 |0.225953074445189 |-1.4874279364673 |20 |11 |0.00242024202420242 |4545 |10287 |FGF19,FGF20,PIK3R1,GRB2,KLB,PTPN11,FGF9,FRS2,FGF2,FGFR4,FGF1 R-HSA-2408522|Selenoamino acid metabolism |0.228055450865703 |-1.47816647404604|121 |58 |0.0127612761276128 |4545 |10287 |RPL21,RPS13,RPS21,RPS15A,IARS,RPL13,HNMT,RPL36,RPL12,RPS3A,RPL5,RPL22L1,SARS,RPS24,RPL34,RPS27,LARS,RPL24,RPL31,PSTK,PAPSS2,RPL15,MARS,TXNRD1,EPRS,RPS5,RPS11,EEF1E1,RPL10A,CTH,AIMP2,AHCY,RPL23A,RPL19,SCLY,RPL38,PAPSS1,RPLP1,GNMT,RPL13A,RPS20,RPS19,RPL26,UBA52,SECISBP2,RPS9,RPL9,RPL18A,GSR,RPL32,AIMP1,RPS16,MIR6805,MAT1A,RPL23,RPS4Y2,RPLP2,RPS15 R-HSA-5693532|DNA Double-Strand Break Repair |0.229016085618733 |-1.47396303501825|167 |79 |0.0173817381738174 |4545 |10287 |XRCC2,UBE2I,HIST1H2BL,ABRAXAS1,POLQ,RPA1,NBN,HIST1H4B,KPNA2,SMARCA5,PARP2,POLD2,XRCC5,UBE2V2,HIST1H2BJ,PPP4C,HIST1H4D,BARD1,NSD2,PPP4R2,EXO1,ATM,UBE2N,BRCA1,TDP1,TOPBP1,UBB,RMI2,ABL1,PPP5C,HIST1H4E,POLE3,CHEK1,PRKDC,NHEJ1,SPIDR,KDM4A,HIST1H4H,SUMO2,ATRIP,ATR,BAZ1B,HIST1H4K,TOP3A,HIST1H4I,HIST1H2BO,LIG3,EYA3,DNA2,PARP1,HIST1H2BH,RAD51B,UIMC1,KDM4B,UBC,LIG4,RPA2,GEN1,RFC3,MDC1,TP53BP1,HIST1H2BC,UBA52,POLE4,RPA3,RFC2,RAD9B,PCNA,POLL,RHNO1,XRCC6,RBBP8,CHEK2,RNF8,CCNA2,TIMELESS,ERCC4,RFC1,RAD51D R-HSA-165159 |mTOR signalling |0.231105440476205 |-1.46488122032505|39 |20 |0.0044004400440044 |4545 |10287 |AKT1S1,LAMTOR4,PRKAB1,STRADA,EIF4B,EEF2K,RHEB,EIF4E,RRAGB,RPTOR,RRAGC,CAB39,YWHAB,MTOR,EIF4EBP1,PRKAA1,PRKAB2,TSC2,PRKAG2,PRKAG1 R-HSA-5696394|DNA Damage Recognition in GG-NER |0.231105440476205 |-1.46488122032505|39 |20 |0.0044004400440044 |4545 |10287 |CETN2,PARP2,COPS5,COPS7B,INO80,UBB,ACTR5,RAD23A,ACTB,COPS8,UBC,INO80C,PARP1,YY1,INO80D,COPS7A,RAD23B,CUL4B,RUVBL1,UBA52 R-HSA-6783310|Fanconi Anemia Pathway |0.231105440476205 |-1.46488122032505|39 |20 |0.0044004400440044 |4545 |10287 |FANCF,UBE2T,RPA2,USP1,FANCL,UBA52,RPA1,FANCM,ATRIP,CENPS,ATR,CENPX,FANCE,FANCB,UBB,FAAP20,RPA3,FANCC,ERCC4,UBC R-HSA-2559583|Cellular Senescence |0.2378364750665 |-1.43617192101051|196 |92 |0.0202420242024202 |4545 |10287 |HIST1H2BH,UBE2D1,UBC,ETS2,CXCL8,HIST1H3C,ANAPC15,HIST1H2BO,HIST1H4I,E2F2,FOS,HIST1H3J,HIST1H4K,H2AFJ,MAPKAPK2,PHC1,CBX4,UBE2C,TNIK,UBN1,HIST1H1C,UBE2E1,MAP3K5,HIST1H4H,ANAPC7,FZR1,MAPK14,CCNA2,SUZ12,EP400,CDKN2B,PHC3,CEBPB,ANAPC4,E2F3,RPS6KA3,H1F0,CBX8,CDK4,TFDP2,UBA52,HIST1H2BC,POT1,LMNB1,CDKN1A,MAP2K6,TERF2,PHC2,RPS6KA2,AGO3,EHMT1,TINF2,ACD,CCNE1,HIST1H2BJ,NFKB1,HIST1H2AE,HIST1H4B,KDM6B,EED,TNRC6C,ID1,RPS6KA1,NBN,RBBP7,STAT3,HIST1H2BL,HIRA,HIST1H1A,MDM2,HIST1H4E,TNRC6A,MIR4738,MDM4,UBB,JUN,TXN,MAP2K7,SCMH1,MAPK1,MAP4K4,H2AFV,H2AFZ,IL1A,CDKN2D,CABIN1,HIST1H4D,MAPKAPK3,MAP2K3,ATM,CDK6,TNRC6B R-HSA-983169 |Class I MHC mediated antigen processing & presentation |0.238048728076141 |-1.43527988645128|373 |172 |0.0378437843784378 |4545 |10287 |UBAC1,ITCH,KLHL21,PSMB10,ASB3,KEAP1,TLR6,FBXO21,CUL2,TRIM71,PSMD14,VAMP8,KCTD6,FBXO22,SEC13,KBTBD13,FBXO44,MEX3C,SAR1B,SEC24A,ATG7,PSMB7,LTN1,PSMD1,ITGB5,PSMA3,ARIH2,SKP1,UBE2F,RLIM,PSMB3,UBE2N,SEC23A,ELOC,VAMP3,UBE2W,UBE2R2,SEM1,PSMB1,UBOX5,LONRF1,UBE2H,ZBTB16,UBE2Q1,STX4,LY96,PSMD12,NEDD4L,TRIM50,HSPA5,KLHL11,PSMA5,TRAF7,SKP2,FZR1,CYBA,UBE2E1,SOCS3,ASB7,SOCS1,FBXO7,UBE2D1,RNF14,FBXO17,MYLIP,PSMA7,FBXO31,SMURF1,SEC22B,CANX,UBE2D3,UBE2G2,CDC34,SEC61A1,FBXW5,FBXO6,SMURF2,KBTBD7,UBE2J2,UBA52,UBE2B,FBXO41,RNF7,FBXO4,SEC61G,ASB1,ZNRF1,PSMC2,UNKL,RNF114,RBBP6,UBR2,PSMB9,PSMF1,SPSB1,PSMA6,SIAH1,PSMC4,ANAPC4,UBE2V1,FBXW11,RBCK1,FBXO32,PSMD7,PSMD3,TRIM69,PSME4,MRC2,FBXW8,VHL,CUL1,PSMB4,UBE2V2,ASB4,FBXL19,LMO7,FBXO15,NEDD4,SIAH2,UBE4A,BTRC,CTSL,KCTD7,WSB1,RNF182,PSMB8,KLHL41,RNF130,UBE2O,SEC24D,RNF217,TRIM37,PSMA1,RNF123,UBB,NCF2,CDC20,RNF138,FBXW2,RNF144B,ANAPC7,KLHL2,UBE2C,UBC,ASB13,UBE2D4,RNF213,TAPBP,FBXL3,CD14,IKBKG,TRIM11,PSMB11,UBE2K,RNF19A,CD36,HACE1,FBXO27,UBA5,KLHL5,ASB14,RNF41,CBLB,UBE2G1,KLHL20,UBE2J1,HECTD2,ASB2,UBE3C,HECTD1,WWP1,PSMB5 R-HSA-350562 |Regulation of ornithine decarboxylase (ODC) |0.23911913213934 |-1.4307933904069 |52 |26 |0.00572057205720572 |4545 |10287 |PSMB1,SEM1,PSMC2,OAZ2,PSMB8,PSMD14,PSMB3,PSME4,PSMA5,PSMB10,PSMD3,PSMD7,PSMB5,PSMA3,PSMB11,PSMA1,PSMD12,PSMC4,PSMA7,PSMD1,PSMB7,PSMA6,PSMF1,PSMB9,OAZ1,PSMB4 R-HSA-5668541|TNFR2 non-canonical NF-kB pathway |0.239993695500667 |-1.4271426247324 |104 |50 |0.011001100110011 |4545 |10287 |PSMA7,PSMD1,TNFSF14,PSMB11,CD40,PSMA3,UBC,PSMB4,CUL1,MAP3K14,TRAF2,PSMB7,PSMD14,CD27,FASLG,EDAR,PSMD7,PSMB10,PSMD3,NFKB2,BIRC2,TNFRSF1A,PSMA5,PSME4,PSMC4,TNFRSF11A,PSMD12,PSMA1,PSMB5,FBXW11,UBB,TNFSF8,PSMB9,PSMF1,TRAF3,EDA,PSMA6,TNFSF18,PSMB3,PSMB8,LTBR,SEM1,PSMC2,PSMB1,TNFSF4,UBA52,BTRC,SKP1,EDARADD,BIRC3 R-HSA-416476 |G alpha (q) signalling events |0.24620369079414 |-1.40159607430377|192 |90 |0.0198019801980198 |4545 |10287 |ADRA1A,APP,KALRN,EDN2,CYSLTR2,HTR2B,GCGR,F2RL3,PIK3R3,BDKRB1,GNG7,HTR2A,GPR17,AGTR1,P2RY2,GNRH1,PROKR2,GNGT2,DAGLB,DGKZ,PIK3R2,KISS1,FFAR2,NPSR1,CHRM5,DGKI,RGS3,GAST,OXT,NMUR2,RGS2,ITPR1,DGKK,MLNR,RGSL1,PLCB1,ABHD6,EDN1,DGKQ,UTS2R,TACR1,DGKA,ANXA1,PMCH,P2RY6,PTGFR,AGT,PRKCE,SAA1,ITPR3,LTB4R2,NTSR2,PIK3R1,GHSR,ITPR2,AVPR1A,KNG1,TACR2,ABHD12,PTGER1,NPS,LPAR6,LTB4R,BDKRB2,XCL2,F2,PROK1,NMBR,TRIO,XCR1,GNB5,PRKCD,NMB,OPN4,GRK5,DGKD,GNA14,TBXA2R,DGKE,TRPC3,MLN,PLCB4,RASGRP2,GNG10,CCKAR,MGLL,ADRA1D,GNG4,PRKCH,GNB4 R-HSA-1474244|Extracellular matrix organization |0.248073891523275 |-1.39402862750472|296 |137 |0.0301430143014301 |4545 |10287 |LINC02478,CMA1,PLOD1,P4HB,ICAM1,DDR2,COL14A1,HSPG2,CDH1,SDC1,PRKCA,SPARC,OPTC,THBS1,MMP7,TNN,PLEC,NTN4,FMOD,MFAP1,P4HA3,LAMA3,ITGB3,P4HA1,MMP20,COL16A1,PCOLCE2,LAMB3,CAPN1,PSEN1,FGF2,LOX,CEACAM8,ICAM3,COL27A1,BMP4,FGG,CTSB,ITGAE,ITGB5,ITGAM,CTSD,DMD,MMP14,PLOD3,ADAMTS2,ELANE,LTBP2,COL5A1,MMP9,LAMB1,ITGB2,COL9A3,NRXN1,PHYKPL,CAPN3,DAG1,LAMC1,COL9A2,ICAM2,FBLN1,FBN3,COL20A1,ITGAL,LOXL2,CAST,COL21A1,ITGAD,VCAN,COL26A1,FN1,SERPINE1,SDC2,FBLN5,ICAM4,TMPRSS6,NID2,LTBP4,COLGALT2,FURIN,SPP1,VTN,MFAP4,ITGAX,ITGA6,COL4A5,LOXL4,MATN3,ITGA2,A2M,COL4A4,ADAM9,COMP,ADAM8,TLL1,CAPN2,ADAM17,PPIB,LAMA5,ITGA1,FBN1,LOXL1,FGA,SDC3,PTPRS,ITGA7,PDGFA,NCSTN,F11R,COL23A1,LTBP1,PLOD2,COL6A3,DST,BMP10,BSG,NID1,SDC4,COL28A1,MMP2,CASK,CAPNS1,MMP11,CAPN13,MMP17,ITGB1,MMP19,CAPN11,PECAM1,TGFB3,MMP15,ACTN1,COL22A1,COL8A1,FGB,CAPN12,CTSL R-HSA-418597 |G alpha (z) signalling events |0.251300444973219 |-1.38110606374885|48 |24 |0.00528052805280528 |4545 |10287 |ADRA2C,ADCY3,GNAI2,GNG7,PRKCA,GNAI1,GNAZ,ADCY9,PRKCD,GNAI3,GNB5,PRKCE,GNGT2,ADRA2A,GNG4,GNB4,PRKCH,ADCY8,GNAS,ADCY1,RGSL1,ADCY7,ADCY4,GNG10 R-HSA-2122947|NOTCH1 Intracellular Domain Regulates Transcription |0.251300444973219 |-1.38110606374885|48 |24 |0.00528052805280528 |4545 |10287 |KAT2B,CUL1,UBC,HDAC5,TLE3,HDAC11,HIF1A,HEYL,HDAC2,NOTCH1,MAML1,HES1,HDAC4,CDK8,UBB,TLE1,EP300,UBA52,SKP1,HDAC8,NCOR2,TBL1X,CREBBP,RBPJ R-HSA-450282 |MAPK targets/ Nuclear events mediated by MAP kinases |0.255812367439134 |-1.36331104292507|31 |16 |0.00352035203520352 |4545 |10287 |DUSP6,JUN,PPP2CA,RPS6KA2,MEF2A,CREB1,DUSP3,MAPK14,PPP2R1B,RPS6KA3,FOS,MAPKAPK2,DUSP7,RPS6KA1,MAPK1,ATF1 R-HSA-5696399|Global Genome Nucleotide Excision Repair (GG-NER) |0.25847274177233 |-1.3529650382829 |85 |41 |0.00902090209020902 |4545 |10287 |INO80C,UBC,COPS8,UBE2V2,PARP1,LIG3,POLD2,PARP2,PIAS1,SUMO3,INO80,ACTB,ACTR5,RAD23B,RPA1,RUVBL1,CUL4B,SUMO2,YY1,UBE2I,COPS7A,XPA,POLE3,RFC1,ERCC4,CETN2,CCNH,COPS7B,PCNA,RFC2,COPS5,RAD23A,UBB,ERCC5,RPA3,POLE4,UBA52,UBE2N,INO80D,RFC3,RPA2 R-HSA-4086400|PCP/CE pathway |0.261380592687707 |-1.34177772428308|96 |46 |0.0101210121012101 |4545 |10287 |PSMB3,PSMB8,AP2B1,AP2A2,DAAM1,FZD4,SEM1,PSMC2,PSMB1,SMURF2,UBA52,FZD2,SCRIB,RYK,PSMC4,PSMD12,PSMA1,PSMB5,UBB,PSMB9,PSMF1,PSMA6,AP2S1,PSMD14,WNT5A,WNT11,FZD5,FZD7,PSMD7,PSMB10,PSMD3,PSMA5,PSME4,PSMD1,PSMA7,SMURF1,RHOA,AP2A1,AP2M1,PSMB11,PSMA3,PFN1,UBC,PSMB4,PRKCA,PSMB7 R-HSA-1280218|Adaptive Immune System |0.26220887429244 |-1.33861386271636|810 |367 |0.0807480748074808 |4545 |10287 |YES1,FBXO27,KIT,FGFR3,AKT1S1,UBA5,TRPC1,RNF41,AGO2,ARF1,CBLB,PPL,RAF1,CASP9,AP2S1,FGF10,EVL,WWP1,MIR4687,DYNC1LI1,CDC20,ULBP1,FRS2,RNF138,FBXW2,ANAPC7,C3,UBE2C,KIF2B,RASGRP2,UBC,MAP3K14,TSC2,TRIB3,RNF213,FBXL3,CD40,TRIM11,RNF19A,CD36,UBE4A,MAP3K8,CTSL,FYN,KCTD7,CTSE,PSMB8,KLHL41,XDH,PHLPP2,RNF130,UBE2O,PIK3AP1,RNF217,PSMA1,PAG1,CD226,UBB,CD247,BTC,PDGFRA,TRIM69,TNRC6C,PSME4,MRC2,SH3KBP1,PDPK1,PPP2R5A,CUL1,KITLG,UBE2V2,FBXL19,LMO7,FBXO15,NFKB1,HLA-DPA1,NEDD4,KBTBD7,SIGLEC11,UBE2J2,UBA52,FGF2,RNF7,PIK3CB,ASB1,ZNRF1,UNKL,RNF114,MALT1,RAP1GAP,UBR2,RBBP6,PSMB9,PSMF1,SPSB1,PPP2CA,CD274,PSMA6,SIAH1,ANAPC4,PSMC4,NCR3LG1,PRR5,FGFR2,CD80,KLHL11,TRAF7,SKP2,FZR1,PAK2,CYBA,HLA-DOB,FOXO3,KIF3C,SOCS3,CTLA4,CDH1,UBE2D1,FBXO7,PSMA7,CSK,FBXO31,NRG1,SEC22B,AP2A1,ICAM1,SEC61A1,CDC34,SOS1,RAB7A,SRC,DCTN4,ARIH2,TREM1,TYROBP,RLIM,ENAH,VAMP3,CARD11,RICTOR,PIP4K2A,UBE2R2,SEM1,BLNK,PSMB1,DNM2,IRS1,PIK3R3,PDGFRB,UBE2H,ZBTB16,STX4,LY96,FGFR1,CD160,NEDD4L,TRIM50,ITGB2,MAPKAP1,AHCYL1,KLC2,ASB3,FBXO21,KEAP1,BTN3A1,CUL2,PSMD14,FGF3,KCTD6,FBXO22,RIPK2,ACTR1B,FBXO44,SAR1B,SEC24A,PSMD1,CTSB,NFKBIA,CD28,PSMA3,INPP5D,PTPRJ,HACE1,ORAI1,FCGR3A,PPP2R1B,AP1M1,FGF9,KLC4,KLHL5,AP2A2,PLCG2,NFKBIB,KIF5B,FGF19,ASB14,DYNC1I2,KLHL20,UBE2G1,UBE2J1,HECTD2,ASB2,UBE3C,HECTD1,PSMB5,LYN,AP1S3,CXADR,SIGLEC1,PAK3,INSR,KLHL2,CALM2,SIGLEC10,RNF144B,FYB1,EGF,BTN3A3,PIP5K1B,ASB13,REL,PHLPP1,UBE2D4,KL,SH2D1B,NR4A1,TAPBP,CD14,GSK3B,IKBKG,ICAM4,IFITM1,PSMB11,UBE2K,MAPK1,SIAH2,BTRC,PIK3R2,ERBB2,RASGRP3,WSB1,RNF182,TNRC6B,KLRK1,MTOR,CREB1,ITGB1,CD34,CTSO,SEC24D,RAPGEF4,TRIM37,DCTN1,RNF123,NCF2,CD96,FBXO32,HBEGF,NCK1,PSMD7,PSMD3,PRKACA,DYNC1H1,ITPR1,GRB2,NRG4,RACGAP1,KRAS,FBXW8,VHL,PSMB4,LGMN,ASB4,CALM1,ERBB3,DCTN2,PDGFA,FBXO6,FBXW5,SMURF2,CTSH,UBE2B,FBXO41,FBXO4,ICAM3,HLA-DMB,CDKN1A,SEC61G,PIK3R1,ITPR2,FGF20,PSMC2,PAK1,IFI30,KIF3B,AP1S2,ITPR3,PIP5K1A,UBE2V1,GSK3A,FBXW11,TAB2,RBCK1,CD81,BTN3A2,HSPA5,YWHAZ,PSMA5,PTPN11,CD101,UBE2E1,CTSC,FGFR4,ASB7,SOCS1,RNF14,FBXO17,MYLIP,KIF4B,SMURF1,RPS6KB2,CANX,AP2M1,UBE2D3,UBE2G2,SKP1,UBE2F,PSMB3,KLB,AP2B1,UBE2N,ITGAL,ELOC,SEC23A,UBE2W,ICAM2,UBOX5,TNRC6A,LONRF1,UBE2Q1,PSMD12,ITCH,UBAC1,KLHL21,KIF20A,PSMB10,TLR6,NRAS,TRIM71,VAMP8,MDM2,AKT3,SEC13,FGF1,KBTBD13,BCL10,SHC1,MEX3C,AGO3,CTSD,ATG7,PSMB7,LTN1,YWHAB,CDC42,JAML,ITGB5 R-HSA-164952 |The role of Nef in HIV-1 replication and disease pathogenesis |0.262689203710503 |-1.33678368054475|29 |15 |0.0033003300330033 |4545 |10287 |AP2B1,AP2A2,PAK2,PACS1,CD28,AP2A1,AP2M1,AP1S3,CD247,ARF1,AP1S2,AP1M1,ELMO1,AP2S1,FYN R-HSA-68886 |M Phase |0.263516676636533 |-1.33363862406018|308 |142 |0.0312431243124312 |4545 |10287 |ANAPC15,HIST1H2BO,HIST1H4I,NUP58,PSMB11,KNL1,UBC,CSNK2A1,HIST1H2BH,CENPU,CENPL,HIST1H4H,NUP214,ANAPC7,CENPC,AHCTF1,AURKB,NUP35,UBE2C,KIF2B,NDE1,NUP42,CNEP1R1,CDC20,LPIN1,PSMB5,NUP205,MCPH1,CLASP1,NUDC,LMNA,SET,RAE1,PPP2R2A,PPP2R1B,ENSA,NUP93,SGO2,RAD21,USO1,NCAPH2,PSMB4,NCAPD2,SEH1L,HIST1H2BL,GORASP2,CENPH,PPP2R5A,PSMD7,RCC2,PSMD3,LPIN2,PSME4,MASTL,PSMA1,INCENP,UBB,CSNK2A2,HIST1H4E,BUB1B,NSL1,PSMB8,ESPL1,STAG1,RANGAP1,RANBP2,MAPRE1,MAPK1,H2AFV,CKAP5,CENPS,NUP210,NUP188,PSMA7,SKA1,HIST1H3C,LPIN3,RPS27,UBE2D1,PRKCA,CENPT,TAOK1,KMT5A,UBE2E1,HIST1H4K,H2AFJ,MAD1L1,CENPF,PSMA5,HIST1H3J,CENPA,PHF8,ANAPC4,PSMC4,RAB2A,CLIP1,PSMF1,PSMB9,CLASP2,PPP2CA,PSMA6,DSN1,BUB1,VRK1,PSMC2,LMNB1,NEK6,UBA52,HIST1H2BC,BUB3,PSMD1,MIR484,PPP1CC,PSMA3,HIST1H2AE,SPC24,HIST1H4B,SEC13,NUP43,HIST1H2BJ,NDEL1,PSMB7,PSMD14,PLK1,PDS5A,KIF20A,PSMB10,HDAC8,ITGB3BP,NUP85,PSMD12,MIR4738,XPO1,PSMB3,RAB1A,SEM1,KNTC1,PSMB1,CSNK2B,HIST1H4D,H2AFZ,PPP2R2D R-HSA-76066 |RNA Polymerase III Transcription Initiation From Type 2 Promoter |0.269899247945181 |-1.30970654538229|27 |14 |0.00308030803080308 |4545 |10287 |GTF3C1,POLR3B,POLR3A,POLR3E,POLR3H,POLR2E,BDP1,POLR3GL,GTF3C6,GTF3C2,CRCP,BRF1,POLR1D,TBP R-HSA-168253 |Host Interactions with Influenza Factors |0.271526573468689 |-1.30369526790165|42 |21 |0.00462046204620462 |4545 |10287 |NUP205,KPNA2,NUP58,CPSF4,NUP85,NUP93,SEH1L,ISG15,KPNB1,NUP43,RAE1,RANBP2,NUP35,NUP214,KPNA3,PABPN1,KPNA1,NUP210,NUP188,NUP42,KPNA7