TermID|Term |Enrichment |logP |Genes in Term|Target Genes in Term|Fraction of Targets in Term|Total Target Genes|Total Genes|Gene Symbols :-----|:-------------------------------------------------------------------------------------|:-------------------|:----------------|:------------|:-------------------|:--------------------------|:-----------------|:----------|:---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- WP1982|Sterol Regulatory Element-Binding Proteins (SREBP) signalling |1.91469889489421e-05|-10.8633650897425|73 |53 |0.0206547155105222 |2566 |5311 |SREBF2,HMGCR,ACACA,MIR33B,ACSS1,AMFR,CDK8,DBI,FASN,KPNB1,RNF139,NR1H2,SEC24D,ATF6,SEC23A,MTOR,PRKACA,PRKAG1,CYP51A1,GPAM,SREBF1,PRKAA1,RBP4,SEC24A,CREB1,SCAP,SIRT1,NFYA,PRKAB2,MIR6886,PRKAB1,SCARB1,ACLY,MBTPS2,PPARG,FDPS,SEC23B,INSIG1,SAR1B,GSK3A,CAMP,MED15,FDFT1,PRKAG2,MBTPS1,LDLR,LPIN1,MDH1,PPARGC1B,SEC13,IDI1,FGF21,YY1 WP437 |EGF/EGFR Signaling Pathway |9.89156437092545e-05|-9.22124315480429|162 |102 |0.0397505845674201 |2566 |5311 |CSK,PRKCZ,RPS6KA3,PTPN12,MAP3K3,FOS,ERRFI1,NCOA3,ARHGEF1,KRAS,JUN,PIK3C2B,MAPK14,EPS15L1,NCK2,SHC1,MAPK4,AP2M1,JAK2,NEDD4,JAK1,MYBL2,RALGDS,SRC,VAV3,CBLB,MAP3K1,LIMK2,MTOR,AP2S1,CAMK2A,NCK1,ABI1,RPS6KA1,RPS6KA2,MAPK1,USP6NL,PTK2,EPS15,ITCH,EIF4EBP1,PEBP1,CRKL,AP2B1,ATXN2,PRKCD,FOSB,STAT5A,EPS8,SOS1,ELK4,ASAP1,CDC42,RALBP1,GJA1,PAK1,PTPRR,GRB10,STAT1,PTK2B,ERBB2,IQGAP1,BCAR1,VAV2,ARF6,MAP2K1,CREB1,RICTOR,CAV1,IQSEC1,ROCK1,RALA,TNK2,AP2A1,MEF2A,RALB,ABL1,STAT5B,EGF,GRB2,PLSCR1,MAP3K4,PRKCI,PTPN5,PRKCA,GAB2,PCNA,ATF1,PDPK1,CRK,PTPN11,INPP5D,SH3KBP1,PIK3R1,BRAF,SPRY2,PLD1,PIK3R2,STXBP1,STAM,RAF1,STAT3 WP481 |Insulin Signaling |0.000131486323307365|-8.93660771702257|161 |101 |0.039360872954014 |2566 |5311 |MAP3K12,SOS1,GSK3A,GRB10,MYO1C,EIF4E,PRKCH,KIF5B,STXBP4,PIK3CB,SH2B2,MAP2K1,ARF6,EHD2,RAPGEF1,SOCS3,GYG1,MAP2K7,GYS2,MAP4K4,PFKL,MAP3K5,PIK3C3,PRKCA,PRKCI,SOCS1,MAP3K4,MAPK6,GRB2,MAP3K8,CYTH3,PTPN11,PRKAA1,CRK,MAP2K6,PIK3C2A,MAP3K14,INSR,EGR1,PDPK1,SLC2A1,STXBP2,PIK3R1,RAF1,RAB4A,TRIB3,EHD1,IRS1,STXBP1,MAP3K9,TSC2,RPS6KB2,VAMP2,PIK3R2,SORBS1,FOS,SRF,MAP3K3,ARF1,PRKCZ,RPS6KA3,SGK2,MAPK14,MAPK4,SHC1,PTPN1,JUN,MAP3K13,SGK3,MAP2K3,PIK3C2G,MAPK13,MAP4K3,GSK3B,PIK3CG,MAP3K1,PIK3R3,STX4,CBLB,TBC1D4,SGK1,MTOR,MAP4K2,RHOQ,RPS6KA1,ENPP1,RPS6KA2,MAPK1,INPP4A,SLC2A4,PTPRF,FLOT2,GYS1,LIPE,PRKCD,XBP1,RHEB,GRB14,SHC3,EIF4EBP1,FOXO3 WP236 |Adipogenesis |0.00016388292489034 |-8.71635825768834|131 |84 |0.0327357755261107 |2566 |5311 |STAT5B,KLF6,MEF2A,HIF1A,CTNNB1,RBL2,CREB1,SOCS3,LPIN3,CYP26A1,GADD45B,STAT1,NR2F1,LPIN1,GTF3A,KLF5,STAT5A,AGPAT2,STAT3,IRS1,PPARA,TRIB3,NR1H3,WWTR1,BMP4,GADD45A,PCK1,OSM,CYP26B1,GDF10,SREBF1,HNF1A,SOCS1,CEBPD,NCOR2,NDN,NRIP1,PPARG,RARA,NCOA1,SMAD3,WNT10B,DDIT3,MIF,CEBPA,SERPINE1,AHR,CEBPB,DLK1,PPARGC1A,PRLR,AGT,LIFR,NR3C1,GATA4,EPAS1,PNPLA3,CDKN1A,RORA,LMNA,LIPE,KLF15,PCK2,PTGIS,MIXL1,BMP3,PLIN2,IGF1,RBL1,SLC2A4,MBNL1,NCOA2,FAS,FRZB,IL6ST,LPIN2,PPARD,STAT6,RXRA,PLIN1,CISD1,CFD,LEP,CELF1 WP3915|Angiopoietin Like Protein 8 Regulatory Pathway |0.000239596326037032|-8.3365550255758 |132 |84 |0.0327357755261107 |2566 |5311 |MAP3K14,PIK3C2A,PDPK1,INSR,PRKAA1,MAP2K6,SREBF1,CRK,MAP3K4,MAP3K8,MAPK6,ABCG8,MAPKAP1,ABCG5,CYP2B6,FASN,RPS6KB2,TSC2,MAP3K9,PCK1,PIK3R2,RAF1,IRS1,NR1H3,PIK3R1,SLC2A1,PRKAG2,PIK3CB,EIF4E,TRIP10,EXOC7,MAP3K12,GSK3A,SOS1,PIK3C3,MAP3K5,MAP4K4,MAP2K7,RAPGEF1,MLXIPL,PRKAB1,MAP2K1,RICTOR,RHOQ,MAP4K2,MAPK1,RPS6KA2,RPS6KA1,RXRA,MTOR,THRA,PRKAG1,FOXO3,EIF4EBP1,SHC3,RHEB,SREBF2,GYS1,FLOT2,SLC2A4,SESN3,MAPK4,SHC1,FBP1,MAPK14,PTPN1,ANGPTL8,RPTOR,DIO2,CYP3A4,RPS6KA3,MAP3K3,G6PC,PIK3R3,CBLB,MAP3K1,GSK3B,MAP4K3,PIK3CG,MAP2K3,MAPK13,PIK3C2G,PRKAB2,MAP3K13 WP2034|Leptin signaling pathway |0.00028652851689319 |-8.15767249135899|76 |52 |0.0202650038971161 |2566 |5311 |SOCS3,ERBB2,CREB1,MAP2K1,IKBKG,SOCS2,BCL2L1,ROCK1,NCOA1,SRC,LEPR,PDE3B,STAT5B,GSK3B,ACACB,FYN,IL1RN,RHOA,SOS1,CDC42,GSK3A,PTPN1,PLCG2,MAPK14,SHC1,JAK2,CISH,EIF4E,JAK1,STAT1,ESR1,ACACA,PIK3R1,CCND1,ROCK2,IL1B,EIF4EBP1,PIK3R2,REL,IRS1,RAF1,STAT3,GRB2,LEP,NFKB1,MTOR,RPS6KA1,MAPK1,CFL2,PTK2,PTPN11,PRKAA1 WP430 |Statin Pathway |0.000322043904135016|-8.04082267346905|33 |26 |0.0101325019485581 |2566 |5311 |ABCA1,CETP,LDLR,MIR6848,APOA1,FDFT1,ABCG8,SOAT1,ABCG5,APOB,APOA5,APOA4,APOC1,LCAT,LIPC,DGAT1,APOC2,APOC3,SCARB1,MIR6886,ACSS1,LRP1,HMGCR,APOA2,MIR33B,PLTP WP3925|Amino Acid metabolism |0.00047535872867523 |-7.65144082069981|91 |60 |0.0233826968043648 |2566 |5311 |MARS2,OGDH,DDC,GCLM,ACSS1,ADH5,AOC3,MAOA,GSR,PCK1,DLST,ACO2,LDHA,GOT1,PDK4,OTC,CTH,FAH,GPT2,HIBADH,ASS1,IARS,HAL,PDHX,FARSB,ALDH1A1,OAT,HDC,BCAT1,HMGCL,MDH2,IDH1,WARS,ACLY,G6PC2,ALDH18A1,PKM,ASNS,CS,PYCR1,ARG1,HADH,ACAA1,HNMT,TAT,ADH7,LARS2,SUCLG1,GOT2,ALDH7A1,HMGCS2,EPRS,GLS,ADH4,MDH1,PPM1L,GSS,CPS1,SMS,PNMT WP2037|Prolactin Signaling Pathway |0.000671757747595611|-7.30561277708433|76 |51 |0.0198752922837101 |2566 |5311 |EIF4EBP1,PPIA,PIK3R2,RAF1,STAT3,IRS1,PIK3R1,IRF1,YWHAZ,NFKBIB,PXN,MAPK1,RPS6KA2,PTPN11,CTSD,PTK2,MTOR,GRB2,NFKB1,GAB2,SOCS1,SRC,PPIB,SIRPA,GSK3B,STAT5B,PIK3CG,VAV2,ITGB1,NEK3,SOCS3,ERBB2,SOCS2,MAP2K1,YWHAG,MAPK14,SHC1,PAK1,PTPN1,PIK3CB,NFKBIA,JUN,JAK1,STAT1,JAK2,CISH,STAT5A,FYN,FOS,PRLR,SOS1 WP368 |Mitochondrial LC-Fatty Acid Beta-Oxidation |0.000732579475005008|-7.21893872465821|17 |15 |0.00584567420109119 |2566 |5311 |SLC25A20,ACADS,ACADL,CPT2,ECI1,PECR,ACADVL,ACSL4,CPT1A,ACSL3,ACSL1,SCP2,ACSF2,HADH,HADHA WP3612|Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |0.000745835720257208|-7.20100519614363|23 |19 |0.00740452065471551 |2566 |5311 |ABCC2,KEAP1,SRXN1,GCLM,MAPK13,NFE2L2,ABCC6,EPHX1,ABCC4,ABCC3,NQO2,GSTP1,FOS,GCLC,HMOX1,ABCG2,MAPK14,CES1,JUN WP2374|Oncostatin M Signaling Pathway |0.000819045535953489|-7.10737087620199|66 |45 |0.0175370226032736 |2566 |5311 |PTPN11,PXN,IL6ST,MAPK1,EGR1,PRKCA,MTOR,GRB2,TIMP3,NFKB1,VEGFA,CCN1,RAF1,STAT3,PRKCD,PRKCE,IRS1,OSM,PIK3R1,JAK1,STAT1,JAK2,SERPINE1,CEBPB,MAPK14,PRKCH,LDLR,SHC1,NFKBIA,KRAS,FOS,SOS1,LIFR,TYK2,STAT5B,SRC,OSMR,HIF1A,MIR6886,JUNB,MAP2K1,RICTOR,CREB1,PTK2B,SOCS3 WP15 |Selenium Micronutrient Network |0.000830332328557194|-7.09368454145862|87 |57 |0.0222135619641465 |2566 |5311 |SCARB1,MTHFR,ALOX5AP,GPX4,PNPO,SELENON,SELENOS,PRDX3,FLAD1,SAA1,XDH,SEPHS2,DIO1,GGT1,F2,GPX2,MIR6886,F7,TXN,PRDX4,SOD2,LDLR,APOA1,PRDX5,SERPINA3,SERPINE1,MTR,GPX3,GPX1,ALOX15B,SELENOM,APOB,DIO2,ICAM1,SELENOP,NFKB2,TXNRD2,SOD1,SELENOI,GSR,RFK,SELENOF,GPX6,PRDX1,KYNU,IL1B,INSR,MSRB1,GGTLC1,CAT,ABCA1,SAA4,NFKB1,TXNRD1,ALB,CTH,PRDX2 WP51 |Regulation of Actin Cytoskeleton |0.00101920216270409 |-6.88873515118622|149 |91 |0.0354637568199532 |2566 |5311 |PIK3C2B,MYH10,FGF10,MAPK4,ARHGEF1,FGF3,BDKRB1,KRAS,ABI2,NRAS,FGF21,PDGFRB,VIL1,RHOA,PIP5K1A,CSK,ENAH,GNA12,ARHGEF6,CHRM5,PIK3R3,PIK3CG,FGFR2,SSH2,PIK3C2G,NCKAP1,MAPK1,WASF1,PIP4K2A,CFL2,PTK2,SSH3,CYFIP2,PIP5K1B,GSN,PDGFRA,BDKRB2,ROCK2,ACTG1,PAK1,PIK3CB,PAK2,PAK3,FGFR4,FGF2,SOS1,FGF14,CDC42,ARPC5,PIK3C3,FGF19,ACTB,FGF9,EGF,IQGAP1,BCAR1,DOCK1,ROCK1,ACTN1,PDGFA,F2,WASF2,MAP2K1,PIK3C2A,PXN,FGF1,ARHGEF4,RRAS2,PIK3R5,CRK,ARHGEF7,MAPK6,ARHGAP35,PAK4,FGFR1,MYLK,DIAPH1,CD14,RDX,PFN1,FGFR3,MRAS,PIK3R2,ITGA1,RAF1,BRAF,PIK3R1,VCL,FN1,SLC9A1,FGF20 WP3613|Photodynamic therapy-induced unfolded protein response |0.00229980662540005 |-6.07493023549463|29 |22 |0.00857365549493375 |2566 |5311 |SULT1E1,DNAJC3,DDIT3,DNAJB11,WARS,NARS,BCL2L11,UBE2E1,NFE2L2,MIR3191,TRIB3,XBP1,ATF3,EDEM1,ASNS,ATF6,HSPA5,EIF2AK3,ATF4,BBC3,ERN1,PPP1R15A WP2380|Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |0.00576415843987284 |-5.15609611338905|144 |85 |0.0331254871395168 |2566 |5311 |EIF4E,ALPL,STAT1,NFKBIA,CDC42,NTF3,CAMK4,FYN,ACACB,STAT5A,CRTC1,MEF2A,STAT5B,ADAM17,MAP2K1,CREB1,SH2B2,IKBKG,CTNNB1,SPP1,KCNA3,PTK2B,DOCK3,VAV2,CNR1,RANBP9,CSNK2A1,FRS3,PRKAA1,DLG1,PTPN11,EGR1,PDPK1,NCF2,GRB2,IRS1,RAF1,STAT3,PIK3R2,BCL2L11,CYFIP1,TSC2,CDH2,PIK3R1,JAK2,SORT1,PPP2CA,JUN,NTRK3,MAPK14,NCK2,SHC1,KSR1,EEF2,FOS,RHOG,RPS6KA3,CDKL5,EIF2S2,GSK3B,NTRK2,SRC,VAV3,MAP3K1,SIRPA,KIDINS220,SQSTM1,RPS6KA1,IGF2BP1,MAPK1,CAMK2A,NCK1,NFKB1,MTOR,GRIA3,DPYSL2,PRKCD,SHC3,CDK5R1,EIF4EBP1,FOXO3,FRS2,SHC4,RASGRF1,PTPRF WP2525|Trans-sulfuration and one carbon metabolism |0.00582797035049703 |-5.14508647808542|32 |23 |0.00896336710833983 |2566 |5311 |GCLC,PHGDH,DNMT3B,DNMT1,CTH,SHMT2,MAT2A,MTHFD2,MAT1A,PSPH,DNMT3A,GSS,MTR,MTHFD1L,AHCYL1,GCLM,PSAT1,AHCYL2,DHFR,AHCY,MAT2B,MTHFR,MTHFD2L WP231 |TNF alpha Signaling Pathway |0.00583298527744027 |-5.14422635522543|94 |58 |0.0226032735775526 |2566 |5311 |TAB2,CYBA,TBK1,CREBBP,TANK,DIABLO,REL,CASP9,KSR2,NFKB2,RAF1,PLK1,RFK,BIRC2,MAP3K8,NFKB1,RIPK1,GRB2,TNFRSF1A,MAP4K2,MAP3K14,BIRC3,SELE,NFKBIB,MAPK1,TRAF1,MAP2K6,CSNK2A1,CASP8,NOX1,MAP2K3,MAP2K7,BCL2L1,IKBKG,FBXW11,MAP3K1,MAP3K5,OTUD7B,CFLAR,BTRC,TRAF2,PRKCZ,TAB1,MAP3K3,KSR1,SOS1,HSP90AA1,SKP1,TAB3,CUL1,JUN,NRAS,KRAS,TXN,NFKBIA,RFFL,PPP2CA,PYGL WP2011|SREBF and miR33 in cholesterol and lipid homeostasis |0.00636451164098938 |-5.05701777560535|19 |15 |0.00584567420109119 |2566 |5311 |MIR33B,HMGCR,MTOR,SREBF2,SIRT1,MIR6886,MED15,PPARGC1A,LDLR,FASN,PPARA,NR1H3,SREBF1,ABCA1,PRKAA1 WP2879|Farnesoid X Receptor Pathway |0.00636451164098938 |-5.05701777560535|19 |15 |0.00584567420109119 |2566 |5311 |NR0B2,CYP3A4,RXRA,SULT2A1,SLC27A5,IP6K3,ABCB4,CYP8B1,UGT2B4,BAAT,NR1H4,FGF19,PPARGC1A,FKBP5,SLCO2B1 WP304 |Kit receptor signaling pathway |0.00654601049733684 |-5.02889949927827|60 |39 |0.0151987529228371 |2566 |5311 |KITLG,STAT3,RAF1,SNAI1,FOXO3,CRKL,PIK3R2,INPP5D,KIT,PIK3R1,CRK,PTPN11,MAPK1,SOCS6,RPS6KA1,SOCS1,GAB2,PRKCA,GRB2,BCL2,GRB7,STAT5B,SRC,MAP2K1,JUNB,EP300,SH2B2,JAK2,LYN,GRB10,STAT1,SHC1,MAPK14,SOS1,FOS,SNAI2,RPS6KA3,FYN,STAT5A WP170 |Nuclear Receptors |0.0065559049978319 |-5.02738910907927|39 |27 |0.0105222135619641 |2566 |5311 |RXRA,NR3C1,NR4A1,RORA,NR5A2,NR5A1,RORC,NR1D2,THRA,PPARD,NR4A2,RXRB,NR2F6,RARG,NR2F1,VDR,NR2F2,ESRRB,ESR1,ESRRA,HNF4A,RARB,NR1H2,RARA,NR1H3,PPARA,PPARG WP2533|Glycerophospholipid Biosynthetic Pathway |0.00876553478783829 |-4.73692774845558|21 |16 |0.00623538581449727 |2566 |5311 |AGPS,PI4K2A,CHPT1,LPIN1,PLA2G2A,GPD1,LPIN2,PGS1,CDIPT,PEMT,CEPT1,PIP5K1A,CRLS1,GNPAT,CDS2,GK WP408 |Oxidative Stress |0.00886343977975268 |-4.72582035271723|31 |22 |0.00857365549493375 |2566 |5311 |TXNRD1,NFKB1,GPX1,GCLC,FOS,CAT,MAPK14,CYP1A1,SOD2,GPX3,HMOX1,XDH,MGST1,CYBA,NFIX,JUNB,TXN2,GSR,SOD1,TXNRD2,MAOA,NFE2L2 WP1403|AMP-activated Protein Kinase (AMPK) Signaling |0.00906907954135178 |-4.70288450386912|68 |43 |0.0167575993764614 |2566 |5311 |EEF2,CDKN1A,ACACB,CRTC2,RPTOR,PPARGC1B,PIK3CB,PRKAG2,STRADA,PRKAB1,PRKAB2,PIK3CG,GYS2,SLC2A4RG,ADRA1A,PIK3R3,LEPR,PIK3C3,PRKAG1,EEF2K,LEP,ADIPOR1,CCNA2,MTOR,SREBF1,ADIPOR2,PRKAA1,INSR,PLCB1,SLC2A4,GYS1,ACACA,PIK3R1,HMGCR,CPT1A,CAB39,LIPE,PIK3R2,EIF4EBP1,HNF4A,FASN,TSC2,RPS6KB2 WP673 |ErbB Signaling Pathway |0.0104268494930562 |-4.56337111762659|54 |35 |0.0136399064692128 |2566 |5311 |SOS1,CDKN1A,STAT5A,NRG1,PDK1,JUN,KRAS,MAP2K1,ERBB2,MAP2K7,BTC,EGF,GSK3B,ABL1,MDM2,SRC,ERBB3,NCK1,CAMK2A,PRKCA,GRB2,PAK4,NRG4,MTOR,PTK2,CRK,TGFA,PIK3R5,MAPK1,AREG,CCND1,AKT3,HBEGF,BCL2L11,EIF4EBP1 WP127 |IL-5 Signaling Pathway |0.0109775475382348 |-4.5119032250222 |40 |27 |0.0105222135619641 |2566 |5311 |MAP2K1,PIK3R1,STAT3,STAT5B,GSK3B,RAF1,PIK3CG,RPS6KB2,FOXO3,PIK3R2,FOS,GSK3A,SOS1,STAT5A,BCL2,GRB2,STAT1,SPRED1,LYN,PTPN11,JAK1,JAK2,SHC1,JUN,MAPK1,RPS6KA1,KRAS WP410 |Diurnally Regulated Genes with Circadian Orthologs |0.0120172898297422 |-4.42140884703291|49 |32 |0.0124707716289945 |2566 |5311 |SUMO3,PIGF,BTG1,MIR6883,DNAJA1,TAB2,ERC2,PER2,ETV6,RBPMS,UCP3,UGP2,PPP1R3C,HERPUD1,STBD1,HSPA8,NCOA4,CRY1,SF3A3,NR1D2,CEBPB,IDI1,QKI,ARNTL,EIF4G2,VAPA,PER1,ZFR,NCKAP1,GSTP1,KLF9,TOB1 WP28 |Selenium Metabolism and Selenoproteins |0.015228074573568 |-4.18461454333912|46 |30 |0.0116913484021824 |2566 |5311 |TXNRD2,SELENOI,SARS,SELENON,GPX4,SELENOS,NFE2L2,GPX6,FABP1,SP3,SEPHS2,DIO1,PSTK,GPX2,POU2F1,SEPHS1,JUN,MSRB1,GPX3,SECISBP2,GPX1,NFKB1,TXNRD1,SELENOM,CREM,DIO2,CTH,SCLY,FOS,SELENOP WP585 |Interferon type I signaling pathways |0.0155286340618485 |-4.16506960049671|55 |35 |0.0136399064692128 |2566 |5311 |STAT3,PDCD4,IRS1,MIR4680,REL,CRKL,EIF4EBP1,PIK3R2,PRMT1,PIK3R1,EIF4B,PTPN11,MAP2K6,CRK,GAB2,MAPKAP1,SOCS1,EIF4A1,MTOR,MAP3K1,IRF9,IFNAR1,CREB1,MAP2K3,SOCS3,RAPGEF1,STAT1,JAK1,EIF4E,MAPK14,PIAS1,FYN,RPTOR,STAT5A,TYK2 WP195 |IL-1 signaling pathway |0.0167105937774437 |-4.09171240274861|57 |36 |0.0140296180826189 |2566 |5311 |TAB1,MAP3K3,IL1R1,MIR718,PRKCZ,IRAK2,MAPK14,TAB3,NFKBIA,JUN,IRAK1,IKBKG,PELI1,MAP2K1,MAP2K3,MAP2K7,MAPKAPK2,MAP3K1,TOLLIP,ECSIT,NFKB1,IL1A,PTPN11,SQSTM1,MAP2K6,NFKBIB,MAP3K14,MAPK1,IL1B,PIK3R1,TAB2,UBE2N,IL1RAP,REL,UBE2V1,PIK3R2 WP179 |Cell Cycle |0.0167416727966426 |-4.08985429079844|105 |62 |0.0241621200311769 |2566 |5311 |CDC25B,TBC1D8,CDK4,E2F2,YWHAZ,ESPL1,HDAC8,RBL1,CDK6,HDAC4,GADD45A,MCM5,ATM,PTTG2,PLK1,CCNE1,KITLG,ORC2,ATR,CCNA2,MCM3,HDAC2,ORC5,CDC20,YWHAB,SMAD4,PCNA,E2F6,ORC1,BUB1,SKP2,ORC6,MCM9,EP300,BUB1B,CCND3,SMAD3,E2F3,MDM2,UBE2F,CHEK1,CHEK2,WEE1,ABL1,GSK3B,CDC7,CDKN1A,MCM10,BUB3,YWHAQ,ARF1,HDAC5,E2F5,CDC14B,MAD1L1,PRKDC,CDH1,YWHAG,CDC6,MCM4,ORC4,CCNH WP2261|Signaling Pathways in Glioblastoma |0.0186017347943779 |-3.98450043409728|83 |50 |0.019485580670304 |2566 |5311 |PIK3C2G,FGFR2,MAP2K7,ERBB2,MAP2K3,EP300,MAP2K1,NF1,SRC,MDM2,PIK3CG,CDKN2B,CDKN1A,PRKCZ,MSH6,ERRFI1,PLCG2,KRAS,PIK3CB,NRAS,PIK3C2B,PRKCH,PDGFRB,AKT3,BRCA1,PDGFRA,PIK3R1,BRAF,CDK4,CCND1,SPRY2,CDK6,PIK3R2,FOXO3,ATM,TSC2,IRS1,RAF1,CCNE1,PRKCD,GRB2,FGFR1,PRKCI,ERBB3,PRKCA,MAPK1,PDPK1,PIK3C2A,MDM4,MAP2K6 WP2864|Apoptosis-related network due to altered Notch3 in ovarian cancer |0.0210192987339522 |-3.86231427593799|54 |34 |0.0132501948558067 |2566 |5311 |ANXA5,IL7R,SMAD7,YBX3,ERBB3,HSPA5,NFKB1,NET1,ERN1,SQSTM1,PTK2,TRAF1,MAPK1,AXIN1,RNF7,SERBP1,MIR8085,BCL3,TNFRSF21,APP,GCLC,CDKN1A,PAK2,NRG1,RIPK2,CUL1,CTNNA1,HSPB1,THBS1,PTK2B,SOCS3,ABL1,VAV3,TNFRSF10B WP366 |TGF-beta Signaling Pathway |0.0240672559560669 |-3.72690303634209|133 |76 |0.029618082618862 |2566 |5311 |MAPK1,AXIN1,SKI,PTK2,SPTBN1,TGFBR2,SIN3A,TGIF1,ITCH,RUNX2,RBL1,CUL1,JUN,PIAS1,MAPK14,MAPK4,SHC1,ITGB3,PDK1,CDKN1A,STRAP,BTRC,APP,RHOA,FOS,SMAD3,WWP1,NEDD4L,SRC,LIMK2,ATF3,NUP214,CDKN2B,KLF10,MAP2K3,JUNB,YAP1,MAP2K6,GRB2,ZEB1,UBE2I,NEDD9,SMAD4,SMAD7,PIK3R2,SMURF2,SMURF1,DAB2,RAF1,PIK3R1,FN1,CCND1,DCP1A,CREBBP,COPS5,SKP1,PAK2,ZFYVE16,FOSB,E2F5,SOS1,CDC42,TAB1,MEF2A,TGFBR3,CITED1,KLF6,ITGB1,ITGA2,BCAR1,THBS1,EP300,CAV1,MAP2K1,RBL2,ROCK1 WP2857|Mesodermal Commitment Pathway |0.0242565533910501 |-3.71906845517779|156 |88 |0.034294621979735 |2566 |5311 |JARID2,CRTC1,ZNF281,RPL38,UBR5,CUL4B,LEFTY1,ELP4,PBX1,FOXA2,SMAD6,TOX3,SMAD1,MACF1,ELK4,KLF5,HAND1,NODAL,TBX1,SNAI1,NFE2L2,RARB,GRHL2,BMP4,FOXA1,DKK1,KLF4,CCND1,PBX3,ASCC3,KIAA0754,RGS10,PRKAR1A,ACACA,BMPR2,MIR373,MEIS1,YAP1,EPB41L5,HES7,TBX3,NLK,WDFY2,SMAD4,FGFR1,FZD5,DNMT3B,CEP250,BMPR1A,ARL4A,MBTD1,SMAD3,WDCP,EMSY,VAV3,MTF2,ARID5B,MIR4321,JAK2,WNT3,PPP2CA,FOXC1,RARG,PIAS1,C9orf72,SRF,EXT1,NOG,ZIC3,PLCH1,FZD4,BHLHE40,ACVR2A,MIXL1,HNF4A,TRIM71,KDM6A,SESN1,MIR125B1,AXIN2,PARP8,AHDC1,TEAD1,AXIN1,PRKACA,AEBP2,TET1,ACVR1 WP286 |IL-3 Signaling Pathway |0.0246940291204968 |-3.70119380058334|49 |31 |0.0120810600155885 |2566 |5311 |INPP5D,RAPGEF1,PIK3R1,MAP2K1,CXCL8,BCL2L1,CRKL,PIK3R2,SRC,STAT5B,STAT3,RAF1,GRB2,STAT5A,BCL2,FYN,YWHAQ,PRKACA,ENPP3,SOS1,IL3,GAB2,FOS,YWHAB,JUN,MAPK1,SHC1,JAK2,PTPN11,LYN,JAK1 WP2878|PPAR Alpha Pathway |0.0253483309178018 |-3.67504239261943|26 |18 |0.00701480904130943 |2566 |5311 |CYP8B1,CCND1,FABP1,APOA2,CDK4,PLTP,CPT1A,NR1H3,PPARA,APOA5,SLC27A1,APOC3,DBI,ACAA1,SCP2,RXRA,CPT2,APOA1 WP325 |Triacylglyceride Synthesis |0.0253483309178018 |-3.67504239261943|26 |18 |0.00701480904130943 |2566 |5311 |PNPLA2,GPD1,MOGAT2,AGPAT2,PLPP1,AGPS,GPAM,MIR6848,PLPP3,AGPAT1,GNPAT,AGPAT3,GK,AGPAT4,MOGAT1,LIPE,LIPC,DGAT1 WP581 |EPO Receptor Signaling |0.0253483309178018 |-3.67504239261943|26 |18 |0.00701480904130943 |2566 |5311 |PDK1,STAT1,JAK2,CISH,SHC1,MAPK1,SOS1,SOCS1,PTPRU,STAT5A,GRB2,RAF1,STAT5B,STAT3,IRS1,PIK3CG,SRC,MAP2K1 WP185 |Integrin-mediated Cell Adhesion |0.0262047746761339 |-3.6418136452716 |103 |60 |0.0233826968043648 |2566 |5311 |ROCK2,CAPNS1,AKT3,ITGAM,VCL,BRAF,ITGAX,CAPN2,ITGA7,RAF1,SHC3,PIK3R2,ITGA1,SORBS1,ITGA6,PAK4,MAPK6,GRB2,ITGAD,ITGAE,ARHGEF7,CRK,TNS1,PTK2,ITGB5,MAP2K6,CAPN3,LINC02478,MAPK1,PDPK1,PXN,CAV1,MAP2K1,ROCK1,CAPN11,RAPGEF1,ITGB1,ITGB2,ITGA2,BCAR1,DOCK1,VAV2,MAP2K3,CAPN1,ITGAL,RHO,VAV3,SRC,SOS1,CDC42,SELENOP,CSK,PAK3,FYN,ITGB3,PAK2,GIT2,SHC1,PAK1,MAPK4 WP2377|Integrated Pancreatic Cancer Pathway |0.0264759780050861 |-3.63151744747493|197 |109 |0.0424785658612627 |2566 |5311 |CHEK2,EGF,ABL1,BRF1,IGFBP3,MDM2,MAP3K5,TOP1,MAP2K1,CREB1,EP300,PDGFA,CTNNB1,BUB1B,LEFTY1,ERBB2,TBP,CASP8,THBS1,CST3,STAT1,SMAD6,NFKBIA,PAK1,GSK3A,FGF2,ANXA1,SOS1,CAMP,STAT5A,NTF3,IL1R1,AGPAT2,NODAL,RAF1,ACHE,CCNE1,GADD45A,LTBP1,RARB,CREBBP,CCND1,HDAC8,BRCA1,CRK,EGR1,FGF1,WT1,HSP90AB1,IL3,SMAD4,MYT1,PCNA,PRKCA,FGFR1,GRB2,MAP3K4,FST,CAPN1,CHEK1,RARA,CDKN2B,DAG1,HPGDS,SHH,SRC,SIRT1,JUNB,MST1,FTL,PDK1,RRM1,BBC3,JUN,KRAS,MAPK4,MAPK14,PIAS1,CDKN1A,ARF1,TRAF2,APP,PLK1,RHEB,CAB39,MIR3191,MIR6869,IGF1,CASP9,ATM,HNF4A,RBL1,DCC,ESR1,FAS,CDK4,FASLG,PDGFRA,MAPK1,FKBP1B,CASP10,NCK1,CAMK2A,TNFRSF1A,NFKB1,VEGFA,RXRA,BCL2,CCNA2 WP299 |Nuclear Receptors in Lipid Metabolism and Toxicity |0.0284681393825715 |-3.55896973344317|35 |23 |0.00896336710833983 |2566 |5311 |NR1H4,RARG,CYP2C9,ABCD3,ABCA1,CYP26A1,CYP3A4,CYP2B6,ABCG5,PPARD,CYP24A1,CYP27B1,RARB,ABCC3,NR1H3,RARA,PPARA,PPARG,VDR,MIR33B,CYP8B1,ABCB4,ABCC2 WP23 |B Cell Receptor Signaling Pathway |0.0308607939069419 |-3.47826870629437|98 |57 |0.0222135619641465 |2566 |5311 |BLNK,E2F3,PTPN18,PIK3CG,GSK3B,RAPGEF1,VAV2,MAP2K1,CREB1,IKBKG,NFKBIA,PLCG2,JUN,MAPK14,SHC1,MAPK4,PIK3AP1,LAT2,BCL10,NFATC3,LYN,FYN,PIP5K1A,SOS1,SH3BP2,GSK3A,CDC42,BCL6,PIK3R2,CRKL,REL,RASGRP3,RAF1,PRKCD,MALT1,CD81,INPP5D,BRAF,PIK3R1,ILF2,RPS6KA1,MAPK1,PDPK1,HCLS1,CRK,MAP2K6,PTPN11,NFATC2,GRB2,NFKB1,GAB2,CAMK2A,CARD11,GTF2I,PIP5K1B,NCK1,IRF4 WP710 |DNA Damage Response (only ATM dependent) |0.0370903017260596 |-3.29439975254313|114 |65 |0.0253312548713952 |2566 |5311 |PIK3C2G,WNT10B,TP73,MIR6886,CCND3,SMAD3,MAP3K1,PIK3R3,PIK3CG,GSK3B,TCF7L2,CDKN1A,MLKL,RHOA,G6PC,WNT11,BCL6,KRAS,JUN,NRAS,BBC3,PIK3C2B,LDLR,SHC1,WNT3,PDK1,HMGB1,FASLG,NFKB2,FOXO3,ATM,TCF7,PCK2,MIR3191,NFKB1,BCL2,MAPK1,AXIN1,CAT,ERBB2,CTNNB1,RBL2,PIK3C3,WNT5A,MDM2,ABL1,SCP2,SOS1,CDC42,WNT7B,PIK3CB,SOD2,AKT3,PIK3R1,CCND1,PIK3R2,CCNG2,BCL2L11,IRS1,GRB2,MAP3K4,SMAD4,INSR,PIK3C2A,PIK3R5 WP1528|Physiological and Pathological Hypertrophy of the Heart |0.037414426886175 |-3.28569890332271|25 |17 |0.00662509742790335 |2566 |5311 |PPP3CA,STAT3,PRKCE,MAP2K3,CALM1,CAMK2D,CALM2,EDN1,MAPK14,JUN,MAPK1,IL6ST,RHOA,LIFR,GATA4,FOS,AGT WP2858|Ectoderm Differentiation |0.0386895405304968 |-3.25218598600586|143 |80 |0.0311769290724864 |2566 |5311 |TCF3,SERPINB6,ZBTB2,TTC14,ARX,CLVS1,BAZ1A,TFAP2C,HMGB2,PDE7A,PODXL,MAFB,GRAMD1B,NR2F2,FGFR2,CAP2,KCNK10,JUP,GLB1,TRPM2,SHH,BCAS3,BMPR1A,CCDC88C,PPARD,HIST1H2BH,PPFIBP2,PLCXD3,FZD4,CDH6,ZNF219,KIFC3,TRIM33,ARHGAP15,FYN,LDB2,RIT1,JAKMIP1,TBL1X,FOXA2,RRBP1,TOX3,PRKAG2,RAB8B,CTNND2,SOCS2,MKS1,HESX1,CTNNB1,FHL2,TSC22D1,SORCS1,PI4KA,VAX2,PIM1,SMAD4,NLK,BCOR,CCDC130,FZD5,ZBTB16,GREB1,NARS2,STX16,OGT,RHPN1,NUMA1,CDON,SPRY2,EDA,C1GALT1,MYORG,PHF8,DMD,PLXNA2,PGM1,ABCC4,SMURF1,TSKU,BMP4 WP364 |IL-6 signaling pathway |0.0394148363729139 |-3.23361297587013|43 |27 |0.0105222135619641 |2566 |5311 |GSK3B,PRKCD,STAT3,NCOA1,PIK3R2,BCL2L1,MAP2K1,CREBBP,JUNB,PIK3R1,IRF1,SOCS3,PTPN11,STAT1,JAK1,JAK2,SHC1,MAPK1,IL6ST,NR2F6,IL6R,NLK,SOS1,AGT,TYK2,PRDM1,GRB2 WP143 |Fatty Acid Beta Oxidation |0.0399439163192496 |-3.22027890073772|34 |22 |0.00857365549493375 |2566 |5311 |HADHA,ACSL3,GK,LIPE,CRAT,ACSL4,CPT1A,LIPC,HADHB,GPD2,PNPLA2,ACSL1,HADH,ECI1,CPT2,ACSL5,ACADVL,ACSL6,SLC25A20,ACADS,ACADL,ACSS2 WP176 |Folate Metabolism |0.041076729928731 |-3.19231349960408|69 |41 |0.0159781761496493 |2566 |5311 |SLC19A1,AHCY,IL1B,GPX6,RFK,SOD1,NFKB2,ALB,CTH,SAA4,NFKB1,ABCA1,INSR,MAT1A,CAT,CSF1,GPX2,F2,DHFR,MIR6886,F7,SAA1,GPX4,FLAD1,SCARB1,MTHFR,MTHFD2,ICAM1,FOLR1,SHMT2,GPX1,APOB,SERPINE1,SERPINA3,MTR,GPX3,MTRR,SOD2,SLC46A1,LDLR,APOA1 WP560 |TGF-beta Receptor Signaling |0.0433371198762774 |-3.13874573925198|58 |35 |0.0136399064692128 |2566 |5311 |SMAD5,TGIF1,LTBP1,TGFBR2,BMP4,STAT3,MIR6869,ZNF423,CREBBP,RUNX2,LINC02478,SKI,SMAD9,TFE3,NFKB1,FST,SMAD4,SMAD7,SMAD3,TGFBR3,EGF,THBS1,EP300,CTNNB1,SPP1,LEFTY1,JUN,SMAD1,SERPINE1,STAT1,SMAD6,JAK1,ENG,NOG,FOS WP2435|Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis |0.0450613835275199 |-3.09972964033223|15 |11 |0.00428682774746687 |2566 |5311 |KEAP1,MAFK,NFKB1,VEGFA,FOS,ACOX2,NFKBIA,JUN,NOS1,NFE2L2,CYP2A6 WP2526|PDGF Pathway |0.0466787946947985 |-3.06446529248843|38 |24 |0.00935307872174591 |2566 |5311 |SRC,MAP3K1,RAF1,STAT3,VAV2,PIK3R1,PDGFA,MAP2K1,PAK1,SHC1,NFKBIA,MAPK1,JUN,JAK1,PTPN11,STAT1,WASL,PDGFRB,RHOA,GRB2,FOS,SRF,SOS1,CDC42 WP3657|Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex |0.0483121124882828 |-3.03007297360777|22 |15 |0.00584567420109119 |2566 |5311 |ZFX,SMARCA4,FOXO3,ATM,DNMT3A,CREBBP,EP300,DNMT1,ETV6,TERF2,SMAD4,MCL1,BCL2L1,BCL2,DNMT3B WP3599|Transcription factor regulation in adipogenesis |0.0483121124882828 |-3.03007297360777|22 |15 |0.00584567420109119 |2566 |5311 |NR3C1,CEBPD,RXRA,LEP,SLC2A4,CREB1,CEBPB,LPIN1,INSR,PPARGC1A,CEBPA,NRIP1,PCK2,IRS1,PPARG WP100 |Glutathione metabolism |0.0483121124882828 |-3.03007297360777|22 |15 |0.00584567420109119 |2566 |5311 |GSTA1,GSR,GGTLC1,GSS,OPLAH,GPX3,GPX4,ANPEP,GGT5,GCLC,GPX1,GCLM,GGT1,GPX2,IDH1 WP1984|Integrated Breast Cancer Pathway |0.0492678905730309 |-3.010482716961 |154 |85 |0.0331254871395168 |2566 |5311 |RHO,USP38,BMPR1A,WEE1,DAG1,ZMYND8,CHEK1,PLK3,MSH2,MAP3K13,PPP4R3A,SIRT1,NUP85,PIAS1,AHR,KRAS,JUN,JAK1,SMARCA4,CERK,NCOA3,ATM,CASP9,TGFBR2,RASGRP3,PLK1,RHEB,RALGAPA1,CDK4,CDC25B,ESR1,BACH1,ZMIZ1,MAPK1,MTOR,BCL2,VEGFA,ATR,ITPKC,NFKB1,NAB1,PPP4R3B,MDM2,RALA,ABL1,UBE2F,CYP19A1,CHEK2,CASP8,NF1,DCAKD,CTNNB1,EP300,CREB1,PAK1,SMAD1,CDH1,JAKMIP1,STAT1,SMAD6,BARD1,USP15,HIPK2,TAB1,CCNB1IP1,MSH6,ANXA1,GSK3A,CDC42,TSC2,PIK3R2,GADD45A,EDAR,IRS1,BMPR2,BRCA1,HMGCR,BRAF,GRIK1-AS2,CCND1,ATF1,TFPI,SMAD7,MYT1,SMAD4 WP3611|Photodynamic therapy-induced AP-1 survival signaling. |0.0492979741680194 |-3.00987229070437|51 |31 |0.0120810600155885 |2566 |5311 |MCL1,BCL2L1,JUNB,CCND1,MAP2K3,FASLG,PDGFRA,HBEGF,FAS,MAP2K7,MAPK13,TNFSF10,CCNE1,NFE2L2,CFLAR,MAP3K5,MIR8085,BCL3,BCL2L11,TNFRSF1A,FOS,HSP90AA1,TRAF2,CCNA2,BCL2,CDKN1A,MAP2K6,BMF,MAPK14,MMP2,JUN WP3850|Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |0.0511312664937577 |-2.97335910012546|31 |20 |0.00779423226812159 |2566 |5311 |IGF1,SMAD3,PIK3CG,IRS1,GSK3B,NEB,ITGB1,PLD1,PRKAB1,MAP1LC3A,PPARGC1A,FBXO32,EIF4E,WASL,PDK1,NFKB1,MTOR,IGFBP5,EIF2B2,TNFRSF1A WP2272|Pathogenic Escherichia coli infection |0.0538088673066779 |-2.92231700556897|55 |33 |0.0128604832424006 |2566 |5311 |WASL,CDH1,ACTG1,NCK2,CDC42,TLR5,YWHAQ,ARPC2,RHOA,FYN,ARPC1A,ABL1,ACTB,CTTN,ARPC5,KRT18,TUBA3E,CTNNB1,ROCK1,ITGB1,ARHGEF2,ARPC5L,CLDN1,HCLS1,PRKCA,CD14,NCK1,LY96,ARPC1B,ROCK2,YWHAZ,TUBB1,TUBB WP2916|Interactome of polycomb repressive complex 2 (PRC2) |0.0542118212541553 |-2.91485628999762|17 |12 |0.00467653936087295 |2566 |5311 |ELL,MTF2,AEBP2,MORC3,SUZ12,THRAP3,RBBP7,JARID2,EZH1,TRIM35,EED,STK38 WP3676|BDNF-TrkB Signaling |0.0553405284497607 |-2.89424975552257|33 |21 |0.00818394388152767 |2566 |5311 |MTOR,GRB2,GAB2,EEF2K,ADCY1,SOS1,SHC1,KRAS,RPS6KA1,MAPK1,NRAS,BRAF,HOMER1,CREB1,MAP2K1,TSC2,NTRK2,EIF4EBP1,TRPC3,RHEB,PIK3CG WP2332|Interleukin-11 Signaling Pathway |0.0559438906865518 |-2.88340604256232|44 |27 |0.0105222135619641 |2566 |5311 |JAK1,PTPN11,STAT1,JAK2,PIAS1,ATF1,RPS6KA1,PDPK1,IL6ST,MAPK1,ICAM1,BCL2,FYN,GRB2,TYK2,RAF1,STAT3,YES1,SRC,PIK3R2,RUNX2,PTPA,MAP2K1,CREB1,PIK3R1,SOCS3,ITGA2 WP314 |Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation|0.0559438906865518 |-2.88340604256232|44 |27 |0.0105222135619641 |2566 |5311 |HSPB1,CYCS,SPTAN1,LMNB1,MAPKAPK3,FASLG,CASP8,FAS,ACTB,MAPKAPK2,CFLAR,MAP3K1,CASP9,LMNB2,PRKDC,NFX1,BCL2,PARP1,LMNA,IL1A,PAK2,FAF1,CASP10,ACTG1,PAK1,JUN,RIPK2 WP3878|ATM Signaling Network in Development and Disease |0.0588091480393513 |-2.83345785727817|46 |28 |0.0109119251753702 |2566 |5311 |CHEK1,CHEK2,TSC2,ATM,MAP3K5,HDAC4,CDK5R1,RNF8,PTPA,IKBKG,HSPB1,MDC1,NBN,AURKB,TP53BP1,RNF20,RASGRF1,PRKAA1,BUB1,LBR,CEP63,RBBP8,PRKDC,MTOR,ATR,NFKB1,ATMIN,PPP5C WP465 |Tryptophan metabolism |0.0588091480393513 |-2.83345785727817|46 |28 |0.0109119251753702 |2566 |5311 |ALDH3A2,ASMT,AOX1,CAT,AANAT,CYP1A1,AADAT,AFMID,HAAO,CYP3A4,CYP2J2,ACMSD,HADH,MAOB,CYP19A1,MDM2,WARS,PRMT1,ALDH2,ALDH1A2,KYNU,CYP4F12,UBR5,ALDH1A1,DHCR24,CYP2C18,DDC,OGDH WP244 |Alpha 6 Beta 4 signaling pathway |0.0593644619038612 |-2.82405951610388|35 |22 |0.00857365549493375 |2566 |5311 |EIF4EBP1,PIK3R2,LAMB1,SRC,ITGA6,LAMA3,IRS1,PRKCD,PIK3R1,LAMB3,LAMC1,LAMA5,MAPK1,MAPK14,SHC1,PTK2,PTPN11,GRB2,MTOR,RHOA,SOS1,PRKCA WP2637|Structural Pathway of Interleukin 1 (IL-1) |0.0642178346361178 |-2.74547430879459|50 |30 |0.0116913484021824 |2566 |5311 |TAB1,FOS,TOLLIP,MKNK2,MAP3K3,IL1R1,MIR718,MAP3K8,MBP,NFKB1,IL1A,MAP2K6,EIF4E,MAPK14,IRAK2,TAB3,NFKBIB,MAP3K14,NFKBIA,MAPK1,IRAK1,TANK,MAP2K1,MAP2K3,TAB2,MAP2K7,MAPKAPK2,SAFB,IL1RAP,MAP3K1 WP138 |Androgen receptor signaling pathway |0.0677192184682732 |-2.69238526241768|90 |51 |0.0198752922837101 |2566 |5311 |SRC,LIMK2,MDM2,SMAD3,NCOA1,GSK3B,ETV5,PARK7,NR0B2,KAT2B,CTNNB1,FHL2,ROCK1,EP300,CREB1,CAV1,SIRT1,PIAS1,DSTN,JUN,CARM1,RHOA,CDKN1A,NCOA3,NCOA4,CDC42,RAN,PIK3R2,SIN3A,PSMC3IP,TGIF1,CCNE1,STAT3,RNF14,PIK3R1,NCOA2,BRCA1,PRDX1,RUNX2,ZMIZ1,CREBBP,CCND1,ROCK2,BMF,PTK2,PLPP1,UBE2I,NCOR2,RHOB,SMAD4,SMARCE1 WP3844|PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |0.0708082303588766 |-2.64778003703201|30 |19 |0.00740452065471551 |2566 |5311 |MTOR,TFEB,RPTOR,PDK1,GRB10,PIK3CB,KRAS,NRAS,RICTOR,PIK3R1,GSK3B,RHEB,ATG13,PIK3CG,TSC2,PIK3R3,PIK3R2,EIF4EBP1,FOXO3 WP382 |MAPK Signaling Pathway |0.0720473641129278 |-2.63043154134284|170 |92 |0.0358534684333593 |2566 |5311 |GADD45A,PPP3CA,MRAS,HSPA8,RAF1,AKT3,GCK,TAB2,BRAF,ACVR1B,ATF4,MAP3K14,MAP2K6,CRK,IL1A,DUSP6,FGFR1,MAP3K8,GRB2,MAPK6,MAP3K4,NLK,PTPN5,RASGRP4,CD14,DUSP10,MAPK8IP3,MAP3K5,MAP4K4,EGF,MAPKAPK2,MAP2K7,CASP8,DUSP5,MAP2K1,DUSP7,DUSP1,NF1,IKBKG,PRKCH,PAK1,PTPRR,PAK2,IL1R1,CDC42,HSPA1A,TAB1,MAP3K12,CRKL,TGFBR2,CASP9,RASGRF2,PRKCD,FAS,CDC25B,FASLG,IL1B,TMEM37,MAPK1,ARRB1,TGFB3,NFKB1,HSPA5,NR4A1,PRKACA,ECSIT,PPM1B,MAP3K1,MAP4K3,STK3,MAPK13,IL1R2,DDIT3,MAP2K3,HSPB1,MAP3K13,NRAS,JUN,KRAS,MAPK4,MAPK14,PDGFRB,TAOK1,RASA2,PRKCZ,RPS6KA3,PPP5C,TRAF2,MAP3K20,SRF,GNA12,FOS WP34 |Ovarian Infertility Genes |0.0756520056967405 |-2.58161132625402|32 |20 |0.00779423226812159 |2566 |5311 |CEBPB,EGR1,PTGER2,GDF9,PRLR,NR5A1,SYNE2,MSH5,ATM,SMAD3,ZP2,NRIP1,CYP19A1,VDR,CDK4,MLH1,TBP,SMPD1,INHA,ZP3 WP2828|Bladder Cancer |0.0756520056967405 |-2.58161132625402|32 |20 |0.00779423226812159 |2566 |5311 |VEGFA,CDKN1A,TYMP,MAPK1,CDH1,RASSF1,CDK4,DAPK1,THBS1,PIK3R1,BRAF,ERBB2,DAPK2,MAP2K1,CCND1,CXCL8,FGFR3,MDM2,PIK3R2,EGF WP615 |Senescence and Autophagy in Cancer |0.0762752783223665 |-2.57340639945304|106 |59 |0.0229929851909587 |2566 |5311 |RAF1,CREG1,GSN,AMBRA1,IGF1,KMT2A,IL1B,IRF1,BRAF,FN1,LAMP1,CDC25B,SERPINB2,IL1A,VTN,SQSTM1,AKT1S1,SH3GLB1,RNASEL,MAPK1,IL6ST,PCNA,SMAD4,IL3,IL6R,MTOR,BCL2,ATG5,ATG10,GSK3B,ATG16L1,ATG13,SRC,MDM2,PIK3C3,IGFBP3,SMAD3,UVRAG,CXCL8,MMP14,MAP2K1,MAP2K3,MAP1LC3B,THBS1,GABARAPL2,SPARC,GABARAPL1,SERPINE1,ATG7,CEBPB,LAMP2,MAPK14,ATG14,JUN,MAP1LC3A,ING1,IGFBP5,CDKN1A,RSL1D1 WP2324|AGE/RAGE pathway |0.0820525934728893 |-2.50039485350085|66 |38 |0.014809041309431 |2566 |5311 |CDC42,PRKCZ,STAT5A,RHOA,JAK2,STAT1,ALPL,JUN,MMP2,NFKBIA,SHC1,MAPK14,MAP2K1,MMP14,CYCS,ROCK1,CASP8,STAT5B,HIF1A,SMAD3,SRC,PRKCA,DIAPH1,AGER,INHBB,NFKB1,MMP7,MAPK1,INSR,MSR1,MMP9,IRS1,PRKCD,STAT3,RAF1,SOD1,CASP9,LGALS3 WP1946|Cori Cycle |0.0820601509960614 |-2.5003027519008 |16 |11 |0.00428682774746687 |2566 |5311 |PFKP,LDHA,PGK1,PGK2,SLC2A2,GPT,SLC2A1,GPI,SLC2A4,TALDO1,GAPDH WP2032|Human Thyroid Stimulating Hormone (TSH) signaling pathway |0.0839121158946507 |-2.47798526717865|68 |39 |0.0151987529228371 |2566 |5311 |GNAI2,MTOR,ADCY3,MAP2K6,GNAS,PLCB1,RPS6KA1,PDPK1,MAPK1,EGR1,PLD1,BRAF,PIK3R1,CDK4,RAF1,CCNE1,STAT3,PIK3R2,MYL12B,FOS,GNA12,JAK1,STAT1,JAK2,MAPK14,SCRIB,JUN,CCND3,RBL2,CREB1,MAP2K1,GNAI3,PDE4D,MAP2K3,PAX8,GNAI1,RAP1GAP,SRC,RALGDS WP3680|Association Between Physico-Chemical Features and Toxicity Associated Pathways |0.0839121158946507 |-2.47798526717865|68 |39 |0.0151987529228371 |2566 |5311 |GSK3B,PIK3CG,SRC,CTNNB1,MAP2K1,FZD7,ERBB2,DAAM1,PPP2CA,SHC1,PAK1,JUN,WNT11,SOS1,RHOA,STAT5A,FZD9,ACTR2,GPX1,CDKN1A,NOS1,RAF1,FZD4,SOD1,NEFL,ROCK2,FN1,ACTR3,PFN2,PTK2,TGFA,AXIN1,MAPK1,NCK1,PFN1,FZD2,FZD5,MYLK,GRB2 WP45 |G1 to S cell cycle control |0.0839121158946507 |-2.47798526717865|68 |39 |0.0151987529228371 |2566 |5311 |ORC2,PRIM2,MCM3,CREB3L1,ORC5,MYT1,PCNA,CREB3,E2F6,CREB3L3,ORC1,TFDP2,CDK4,CCND1,E2F2,RBL1,CREB3L4,CDK6,CCNG2,GADD45A,ATM,MCM5,CCNE1,CDKN1A,E2F5,RPA1,RPA2,CDKN2D,MCM4,ORC4,CCNH,ORC6,RPA3,CREB1,CCND3,E2F3,MDM2,CDKN2B,WEE1 WP2895|Differentiation of white and brown adipocyte |0.0846598959901118 |-2.4691132724501 |25 |16 |0.00623538581449727 |2566 |5311 |BMP4,SMAD5,CIDEA,PPARG,CEBPG,ZNF423,PLAC8,CEBPB,HSPB7,PPARGC1A,SMAD1,CEBPA,PPARGC1B,SMAD9,LEP,SLC7A10 WP205 |IL-7 Signaling Pathway |0.0846598959901118 |-2.4691132724501 |25 |16 |0.00623538581449727 |2566 |5311 |MAP2K1,CCND1,BCL2L1,PTK2B,PIK3R1,STAT5B,STAT3,GSK3B,PIK3R2,IL7,IL7R,FYN,STAT5A,STAT1,JAK1,MAPK1 WP3668|Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |0.0846598959901118 |-2.4691132724501 |25 |16 |0.00623538581449727 |2566 |5311 |TGFBR3,CCN2,LTBP1,SMAD3,TGFBR2,RUNX2,FBN1,AGTR1,LTBP2,FBN3,SERPINE1,SHC1,MAPK14,MAPK1,SMAD4,ENG WP3646|Hepatitis C and Hepatocellular Carcinoma |0.0855319210186813 |-2.45886562746768|51 |30 |0.0116913484021824 |2566 |5311 |CTTN,HIF1A,SMAD3,CASP9,STAT3,CXCR1,AOPEP,FASLG,BRCA1,VAV2,CCND1,CXCL8,E2F2,BCL2L1,JUN,PODXL,MAPK14,BIRC3,FRZB,PTPN11,MYOF,JAK1,VEGFA,NFKB1,CDKN1A,GRB2,IL6R,SOS1,SMAD4,HNF1A WP3594|Circadian rythm related genes |0.0891477432263954 |-2.41746024933557|207 |110 |0.0428682774746687 |2566 |5311 |HNRNPU,PPARGC1A,NTRK3,JUN,CUL1,AANAT,AHR,ZFHX3,DDX5,SERPINE1,ARNTL,RORA,UBA52,CREM,BTRC,NPS,PASD1,PRKDC,NPAS2,PPARG,PROKR2,NRIP1,GSK3B,ID4,KLF10,FBXW11,SIRT1,NR1D1,FBXL3,UBC,CLDN4,LEP,CARTPT,ADCY1,ID2,CSNK1E,HNF1B,SIN3A,BHLHE40,FAS,RAI1,NCOA2,CDK4,EGR3,ROCK2,AHCY,NR2F6,SKP1,CST3,PSPC1,NFIL3,GHRH,NR1D2,TNFRSF11A,KCNMA1,USP2,CRY1,NAGLU,TOP1,ARNT,PHLPP1,CRTC1,HNRNPD,KLF9,PER1,PRF1,HEBP1,EP300,PER3,CREB1,CIPC,F7,ATF4,TPH2,EGR1,PPP1CC,OGT,MIR6883,DRD2,SREBF1,PRKAA1,PPP1CB,NKX2-1,DYRK1A,RBM4,TIMELESS,HDAC2,DRD4,RORC,OPN3,SFPQ,UTS2R,KMT2A,DBP,MC3R,SLC6A4,GFPT1,PPARA,NR1H3,CPT1A,HS3ST2,THRAP3,DDC,HOMER1,STAR,PROX1,ATOH7,PROK1,OPN4,PER2 WP3879|4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |0.0922924220076501 |-2.3827932426028 |18 |12 |0.00467653936087295 |2566 |5311 |MTOR,MAP2K3,MAP2K1,MKNK2,MAP3K5,MAPK1,PBK,EIF4EBP1,PRKAA1,RAF1,EIF4E,MAP2K6 WP3859|TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |0.0922924220076501 |-2.3827932426028 |18 |12 |0.00467653936087295 |2566 |5311 |SMAD3,CDH1,MAPK1,ID1,SNAI1,CDH6,CDH16,FN1,RUNX2,SNAI2,SMAD4,CDH2 WP716 |Vitamin A and Carotenoid Metabolism |0.0993388042335629 |-2.30921900648467|44 |26 |0.0101325019485581 |2566 |5311 |RETSAT,RXRA,ABCG8,ABCG5,SULT1A1,RXRB,MIR6848,RARG,MAPK1,ADH4,CYP26A1,ALDH1A1,RLBP1,CYP26B1,RDH12,RBP4,SULT2B1,ALDH1A2,RARB,RDH10,DGAT1,CD36,SCARB1,ALDH1A3,RARA,DHRS3 WP732 |Serotonin Receptor 2 and ELK-SRF/GATA4 signaling |0.101454307412484 |-2.28814675513472|20 |13 |0.00506625097427903 |2566 |5311 |NRAS,MAPK1,KRAS,HTR2A,MAPKAPK2,RAF1,RASGRF1,ITPR1,HTR2B,GATA4,MAP2K1,SRF,ELK4 WP516 |Hypertrophy Model |0.101454307412484 |-2.28814675513472|20 |13 |0.00506625097427903 |2566 |5311 |IFRD1,EIF4EBP1,DUSP14,IL1A,ATF3,EIF4E,IL1R1,CCN1,VEGFA,HBEGF,ZEB1,WDR1,ANKRD1 WP1971|Integrated Cancer Pathway |0.102537840262556 |-2.27752337523814|46 |27 |0.0105222135619641 |2566 |5311 |ATF1,BBC3,BARD1,JAK1,STAT1,CDKN1A,ATR,BCL2,MSH6,SMAD3,CASP9,ATM,MAP3K5,MDM2,CHEK2,PLK1,CHEK1,CDKN2B,MIR3191,CDC25B,MSH2,BACH1,BRCA1,CASP8,CDK4,GRIK1-AS2,POU2F1 WP2884|NRF2 pathway |0.104395483830506 |-2.25956886279775|143 |77 |0.0300077942322681 |2566 |5311 |GPX3,NRG1,SLC39A14,UGT2B7,SLC39A10,CES1,SLC2A5,MGST3,HSP90AA1,UGT1A4,HSPA1A,ADH7,SLC2A11,PTGR1,SERPINA1,SLC39A11,SLC6A14,MGST2,GGT1,GPX2,SLC6A1,SLC5A10,TGFA,EGR1,GGTLC1,MAFF,SLC39A13,HSP90AB1,AGER,SLC5A11,SLC6A7,ABCC4,NFE2L2,SLC6A11,GSR,SLC6A4,SLC2A1,HBEGF,FTL,SLC5A5,SLC2A2,TXN,PRDX6,SLC2A8,GCLC,SLC7A11,DNAJB1,BLVRB,GSTP1,CES4A,SLC6A17,GSTA1,SLC5A12,EPHA2,HMOX1,SQSTM1,PGD,SLC2A9,SLC6A6,PPARD,TXNRD1,RXRA,FTH1,CYP2A6,SLC6A2,TGFBR2,ABCC3,SLC2A4,SLC6A5,ABCC2,GSTA3,GCLM,SLC5A9,PRDX1,KEAP1,SLC2A14,SLC2A10 WP2848|Differentiation Pathway |0.105559998049778 |-2.24847578582202|48 |28 |0.0109119251753702 |2566 |5311 |LEFTY1,NOTCH1,PDGFA,DKK1,KIT,CSF1R,KITLG,EGF,CXCR1,NODAL,TF,BMP4,SHH,WNT5A,IGF1,WNT7B,IL3,FGF2,IL6R,NOG,FST,VEGFA,TGFB3,ALK,CSF1,FGF10,NT5E,FGF1 WP167 |Eicosanoid Synthesis |0.109680290298525 |-2.21018559695437|22 |14 |0.00545596258768511 |2566 |5311 |GGT1,ALOX15,PLA2G2A,LTA4H,PNPLA3,ALOX15B,DPEP1,PTGIS,TBXAS1,PTGES,PNPLA8,GGTLC1,PLA2G6,ALOX5AP WP357 |Fatty Acid Biosynthesis |0.109680290298525 |-2.21018559695437|22 |14 |0.00545596258768511 |2566 |5311 |ACACA,ACSL1,ACSL3,ACACB,HADH,PECR,ACSL4,ACSL5,ACSL6,ECHDC2,ECH1,FASN,ACLY,ACSS2 WP1471|Target Of Rapamycin (TOR) Signaling |0.115743491516187 |-2.15637881639853|37 |22 |0.00857365549493375 |2566 |5311 |MTOR,RPTOR,PRKCA,PRKAG1,CDC42,MAPKAP1,DDIT4,RRAGC,PRKAG2,IDI1,PRKAA1,AKT1S1,HMGCR,RRAGB,PRKAB1,PRKAB2,RICTOR,TSC2,EIF4EBP1,PRR5,MIR6869,RHEB WP1539|Angiogenesis |0.117089808268901 |-2.14481404659059|24 |15 |0.00584567420109119 |2566 |5311 |PTK2,MAPK1,HIF1A,SMAD1,ARNT,SRC,MAPK14,CREBBP,FGF2,MMP9,VEGFA,FGFR2,TIMP3,TEK,PDGFRA WP2509|Nanoparticle triggered autophagic cell death |0.117089808268901 |-2.14481404659059|24 |15 |0.00584567420109119 |2566 |5311 |ATG16L1,MIR21,ATG7,CHAF1A,ATG10,INSR,VMP1,MAP1LC3A,ATG14,AMBRA1,SH3GLB1,TSC2,UVRAG,BCL2,ATG5 WP3678|Amplification and Expansion of Oncogenic Pathways as Metastatic Traits |0.133115422189186 |-2.01653869110341|17 |11 |0.00428682774746687 |2566 |5311 |PIK3CG,CXCR4,TCF7,TCF7L2,SRC,VHL,NOTCH1,JAG1,VEGFA,CYTIP,EPAS1 WP22 |IL-9 Signaling Pathway |0.142964462664046 |-1.9451591924455 |19 |12 |0.00467653936087295 |2566 |5311 |JAK1,IL9,STAT3,STAT5B,STAT1,PIK3R2,MAPK1,IL9R,MAP2K1,GRB2,PIK3R1,STAT5A WP2018|RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |0.143413765655794 |-1.94202136061354|55 |31 |0.0120810600155885 |2566 |5311 |PIK3R1,TAB2,MAP2K7,IKBKG,FHL2,TRAF3,MAP2K1,SRC,PAPSS2,NFKB2,PIK3R2,TRAF2,MTOR,SPI1,NFKB1,FOS,GAB2,TAB1,TNFRSF11A,ICAM1,CDC42,MAPK14,NFKBIA,MAPK1,TRAF1,JUN,STAT1,LYN,SQSTM1,PTK2,MAP2K6 WP1601|Fluoropyrimidine Activity |0.145026794253825 |-1.93083676567534|34 |20 |0.00779423226812159 |2566 |5311 |MIR3658,CYP2A6,ABCC4,ABCC3,FPGS,MTHFR,UCK1,UPP2,DHFR,UPB1,GGH,UMPS,UCK2,RRM1,UPP1,SLC22A7,ABCG2,TYMP,CES1,DPYS WP313 |Signaling of Hepatocyte Growth Factor Receptor |0.145026794253825 |-1.93083676567534|34 |20 |0.00779423226812159 |2566 |5311 |MAPK1,JUN,PXN,PAK1,CRK,PTK2,PTPN11,GRB2,SOS1,FOS,ITGA1,CRKL,SRC,RAF1,STAT3,RAPGEF1,ITGB1,PTK2B,DOCK1,MAP2K1 WP3298|Melatonin metabolism and effects |0.149252585188123 |-1.90211520566598|36 |21 |0.00818394388152767 |2566 |5311 |ARNTL,ECE1,CYP1A1,IRAK1,MIR6883,CRY1,CAMK2A,PRKCA,NFKB1,MIR718,GSK3B,ACHE,CSNK1E,MAOA,SIRT1,PER3,EDN1,CALM2,PER2,PER1,CALM1 WP524 |G13 Signaling Pathway |0.156714177007857 |-1.85333166142245|40 |23 |0.00896336710833983 |2566 |5311 |ARHGEF1,PIK3CB,PIP4K2A,WASL,CFL2,PPP1CB,PAK3,RHOA,MAP3K4,PFN1,CDC42,DIAPH1,PIK3R2,TNK2,CYFIP1,RTKN,RHPN2,IQGAP1,CALM1,IQGAP2,CALM2,ROCK2,ROCK1 WP712 |Estrogen signaling pathway |0.159080635612595 |-1.83834406309748|23 |14 |0.00545596258768511 |2566 |5311 |GPER1,JUN,MAPK1,GNAS,MAPK14,MAP2K1,CREB1,PRKACA,FOS,IKBKG,NFKB1,ESR1,BRAF,BCL2 WP466 |DNA Replication |0.160015765758516 |-1.83248293261193|42 |24 |0.00935307872174591 |2566 |5311 |MCM5,ORC6,RPA3,CDT1,UBC,RPA2,CDC6,ORC1,MCM4,GMNN,ORC4,CDC7,ORC2,PRIM2,RFC2,UBA52,MCM10,MCM3,RPA1,ORC5,POLD2,RFC3,RFC1,PCNA WP2636|Common Pathways Underlying Drug Addiction |0.160015765758516 |-1.83248293261193|42 |24 |0.00935307872174591 |2566 |5311 |GNAS,ACTG1,PPP1CC,MAPK1,PPP1CB,ADCY8,DRD2,GRIA3,CAMK4,ADCY1,PRKCA,CAMK2A,PRKACA,DRD4,PPP1R1A,ACTB,RAF1,GRIN2A,CALM1,GNAI1,MAP2K1,CREB1,CALM2,GJB1 WP49 |IL-2 Signaling Pathway |0.160015765758516 |-1.83248293261193|42 |24 |0.00935307872174591 |2566 |5311 |PIK3R1,PTK2B,SOCS3,MAP2K1,RPS6KB2,FOXO3,CRKL,STAT3,STAT5B,RAF1,STAT5A,BCL2,FYN,GRB2,GAB2,FOS,SOS1,SHC1,JUN,MAPK1,STAT1,PTPN11,JAK1,CISH WP2643|Nanoparticle-mediated activation of receptor signaling |0.176920835329474 |-1.73205290448358|29 |17 |0.00662509742790335 |2566 |5311 |PTK2,PXN,MAPK14,NRAS,MAPK1,KRAS,SOS1,GRB2,RAF1,SRC,ITGA1,MAP2K1,AREG,FN1,AKT3,MAPK13,ITGB1 WP2853|Endoderm Differentiation |0.179492495134874 |-1.71762188176143|145 |76 |0.029618082618862 |2566 |5311 |DUSP5,CAND1,CTNNB1,UBR5,CUL4B,PAX9,HHEX,JARID2,CRTC1,ZNF281,ELK4,TOX3,STAT1,PBX1,ELP4,FOXA2,ACACA,MIR373,RGS10,ASCC3,DKK1,PBX3,GRHL2,FOXA1,DAB2,NODAL,CEP250,DNMT3B,SMAD4,NLK,WDFY2,WWC1,EPB41L5,NKX2-1,MAP2K3,MTF2,VAV3,EMSY,BPTF,BMPR1A,SMAD3,MBTD1,APP,NOG,GATA4,NR3C1,ZIC3,PLCH1,ZBTB17,EXT1,PIAS1,GLI2,CTR9,RARG,WNT3,SFMBT1,ONECUT1,SESN1,NOTCH1,LAMC1,PABPC1,TNRC6C,TRIM71,FOXN3,HNF1B,MIXL1,KDM4A,TCF7,LRPPRC,RFX7,TET1,AEBP2,SIAH2,PRDM14,PARP8,AHDC1 WP3584|MECP2 and Associated Rett Syndrome |0.182409556764913 |-1.70150080816997|62 |34 |0.0132501948558067 |2566 |5311 |GRID1,HNRNPH1,TET2,HNRNPF,CREB1,DLX6,NF1,ARHGEF26,CTCF,SP3,FKBP5,GAMT,RBFOX1,FGF3,FGF2,BCL6,MBP,SIN3A,DLX5,POU3F2,CDON,GABRR2,CNP,NREP,IGF2,TAF1,MAG,REST,SGK1,MYT1,CAMK2A,TET1,CEBPD,MTOR WP3651|Pathways Affected in Adenoid Cystic Carcinoma |0.185289591523989 |-1.68583531821295|66 |36 |0.0140296180826189 |2566 |5311 |KDM6B,MYB,BCOR,JMJD1C,SMARCE1,FOXO3,ATM,KANSL1,RAF1,BRCA1,KAT6A,MYCN,NOTCH1,KDM6A,CREBBP,ARID4B,UHRF1,TLK1,ERBIN,CEBPA,FGFR4,FOXP2,PRKDC,MAGI1,MORF4L1,MYBL1,SMARCA2,NFIB,CHEK1,CHEK2,DTX4,ERBB2,BRD1,ARID5B,EP300,CMTR2 WP3303|Rac1/Pak1/p38/MMP-2 pathway |0.186590428030599 |-1.67883928861238|68 |37 |0.0144193296960249 |2566 |5311 |TNIP1,SOS1,STAT5A,PAK1,MAPK14,NRAS,KRAS,NFKBIA,CTNNB1,ANGPT4,IKBKG,TEK,MAPK13,ERBB2,MSH2,ITGB1,STAT5B,GRB7,SRC,NCK1,NFKB1,GRB2,PTPN11,PTK2,CRK,PXN,MAPK1,YAP1,ANGPTL1,FN1,RS1,PIK3R1,STAT3,NOS1,GRB14,EIF4EBP1,CASP9 WP3617|Photodynamic therapy-induced NF-kB survival signaling |0.189751514350002 |-1.66203988197407|35 |20 |0.00779423226812159 |2566 |5311 |BIRC2,VEGFA,NFKB1,TNFRSF1A,EGLN2,ICAM1,CXCL2,SELE,BIRC3,MMP2,IL1A,BCL2L2,MMP9,IL1B,CCND1,CXCL8,REL,NFKB2,BCL2A1,CFLAR WP2446|Retinoblastoma (RB) in Cancer |0.195756821762039 |-1.63088209535938|88 |47 |0.0183164458300857 |2566 |5311 |RPA2,PRMT2,HMGB2,RRM1,MCM4,BARD1,CDKN1A,CDC7,PRKDC,RPA1,MSH6,E2F3,SMARCA2,MDM2,WEE1,ABL1,CHEK1,SKP2,MAPK13,CCND3,ANLN,RPA3,PLK4,DHFR,H2AFZ,FAF1,TFDP2,DCK,ORC1,RBBP7,CCNA2,MCM3,RABIF,PCNA,DNMT1,RFC3,SIN3A,CDK6,CCNE1,RAF1,NPAT,CDK4,HMGB1,CDC25B,CDT1,E2F2,CCND1 WP1422|Sphingolipid Metabolism |0.205229695537641 |-1.58362546106003|20 |12 |0.00467653936087295 |2566 |5311 |CERK,CERS2,SPTLC2,CERS6,SGMS2,CERS4,ASAH2,KDSR,SPHK1,PLPP1,SPTLC3,SPHK2 WP497 |Urea cycle and metabolism of amino groups |0.205229695537641 |-1.58362546106003|20 |12 |0.00467653936087295 |2566 |5311 |ASS1,GAMT,SMS,CPS1,CKB,ASL,ALDH18A1,OAT,OTC,PYCR1,ARG1,GATM WP2203|Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |0.206493446520139 |-1.5774866030646 |47 |26 |0.0101325019485581 |2566 |5311 |MAP2K1,CXCL8,STAT3,STAT5B,TNFSF4,YES1,SRC,EIF4EBP1,NFKB2,IL7R,GAB2,STAT6,FYN,STAT5A,MTOR,NFKB1,LYN,STAT1,PTPN11,JAK1,CISH,JAK2,MAPK14,PI4K2A,MAPK1,NFKBIA WP1533|Vitamin B12 Metabolism |0.212046055521027 |-1.55095178488026|53 |29 |0.0113016367887763 |2566 |5311 |SHMT2,ICAM1,CTH,ALB,APOB,NFKB1,SAA4,ABCA1,MTRR,LRP2,SERPINA3,MTR,SERPINE1,LDLR,APOA1,MCEE,SOD2,INSR,MAT1A,IL1B,F7,MIR6886,F2,SAA1,MMAB,SCARB1,MTHFR,NFKB2,SOD1 WP262 |EBV LMP1 signaling |0.217867793896021 |-1.52386685017649|24 |14 |0.00545596258768511 |2566 |5311 |MAP3K3,CXCL8,HSP90AA1,IKBKG,NFKB1,PDLIM7,MIR718,CCL20,IRAK1,TRAF1,MAPK1,NFKB2,NFKBIA,MAP3K14 WP35 |G Protein Signaling Pathways |0.227764394797083 |-1.47944354046141|95 |50 |0.019485580670304 |2566 |5311 |GNAS,AKAP13,GNGT2,AKAP7,ADCY8,ADCY3,GNG10,PRKCI,GNA14,GNAI2,PRKACA,PRKCA,ADCY1,MIR7706,LOC729966,GNAL,PPP3CA,AKAP10,GNAZ,PRKCE,PRKCD,AKAP12,KCNJ3,PRKAR1A,CALM1,SLC9A1,AKAP6,ITPR1,CALM2,KRAS,ARHGEF1,NRAS,AKAP1,PDE7A,GNG7,PRKCH,PDE4A,PRKCZ,RHOA,AKAP9,ADCY9,GNA12,GNB5,ADCY4,ADCY7,GNAI1,PDE4B,PDE4D,GNG4,GNAI3 WP2870|Extracellular vesicle-mediated signaling in recipient cells |0.231242591584092 |-1.46428793949589|30 |17 |0.00662509742790335 |2566 |5311 |ERBB2,CTNNB1,SMAD3,TGFBR2,WNT5A,DKK4,TGFBR3,RAF1,MTOR,PROM1,SMAD4,KRAS,NRAS,AXIN1,TGFA,TGFB3,PIK3R5 WP500 |Glycogen Metabolism |0.240375175804334 |-1.42555434369818|36 |20 |0.00779423226812159 |2566 |5311 |PPP2CA,PYGL,GSK3A,PPP2R2C,PYGB,GBE1,PGM1,GYS2,PPP2R2A,GSK3B,UGP2,PHKB,PPP2R3B,CALM2,PTPA,PPP2R1B,GYS1,GYG1,PPP2R5A,CALM1 WP2516|ATM Signaling Pathway |0.244894340671385 |-1.40692842402363|40 |22 |0.00857365549493375 |2566 |5311 |CDKN1A,RIPK1,NFKBIA,TLK1,JUN,MDM4,TP53BP1,BRCA1,AP3B2,NBN,MDC1,CREB1,IKBKG,TP73,GADD45A,ATM,MDM2,CRADD,CHEK1,CHEK2,CCNE1,ABL1 WP1591|Heart Development |0.25001626532196 |-1.38622930194844|46 |25 |0.00974279033515199 |2566 |5311 |GATA4,VEGFA,SMAD4,HAND1,MIR145,ERBB3,SRF,FGF10,MAPK1,FOXC1,SMAD1,NFATC2,PTPN11,NFATC3,FOXA2,BMPR2,CTNNB1,BMP10,NOTCH1,BMP4,SHH,BMPR1A,TBX1,BHLHE40,NKX2-5 WP1772|Apoptosis Modulation and Signaling |0.260240807038912 |-1.34614789568862|94 |49 |0.0190958690568979 |2566 |5311 |MIR718,IL1R1,HSPA1A,FOS,BBC3,JUN,IRAK1,NFKBIA,BAG3,BCL2L2,CASP8,IL1R2,TRAF3,BCL2L1,MCL1,CYCS,TNFRSF10B,XIAP,MAP3K5,BCL2L10,BIRC6,CFLAR,RIPK1,NFKB1,BIRC2,BCL2,TNFRSF10D,SEPTIN4,AIFM2,TOLLIP,TNFRSF1A,MAP3K14,BIRC3,CASP10,TNFRSF10C,BMF,CASP4,FAS,BNIP3,FASLG,CAPNS1,BCL2L11,CASP9,DIABLO,PTRH2,CRADD,MIR3191,BCL2A1,TNFSF10 WP734 |Serotonin Receptor 4/6/7 and NR3C Signaling |0.27193026007292 |-1.30220964235215|19 |11 |0.00428682774746687 |2566 |5311 |MAPK1,EGR1,ATF1,GNAS,MAPKAPK2,NR3C1,BRAF,CREB1,MAP2K1,SRF,ELK4