TermID |Term |Enrichment |logP |Genes in Term|Target Genes in Term|Fraction of Targets in Term|Total Target Genes|Total Genes|Gene Symbols :---------|:---------------------------------------------------------|:-------------------|:----------------|:------------|:-------------------|:--------------------------|:-----------------|:----------|:--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- hsa01100 |Metabolic pathways |4.61436341279929e-06|-12.2863366382456|1256 |239 |0.22483537158984 |1063 |7161 |GALNT2,NDUFS7,GALNT16,CYP27A1,CRLS1,GRHPR,GFPT1,ALDH3B1,HMOX1,SMPD4,ACSL6,MAT1A,CSAD,INPP1,UXS1,PIGY,DHRS3,MRI1,ATP5MC2,NME1,PFKL,COX5B,DNMT3B,SPHK1,NDUFV2,CERS2,ATP6V1B2,ENPP7,GUK1,PYGB,ACP1,GSS,PIGC,CRPPA,ACOX1,PCK2,MGAT1,OAT,PLD1,DHCR7,GLUL,LIPT1,NDUFS5,IDNK,NDUFA7,ITPA,HAL,GANC,POLE2,ACADM,GCNT3,NADK,ACADVL,AGPAT1,SUCLA2,ITPKC,QPRT,TYMS,CYP3A5,COX4I2,B3GNT2,POLR1D,MMUT,SUCLG2,ATP6V0D1,DAO,FCSK,GAA,ADI1,NME2,NT5C,DHRS4L1,ATP5MC1,HSD3B7,UGT2B10,ATP5ME,NDUFS6,ATP6V1F,IDUA,ENO1,ALG2,UQCRC2,ODC1,SLC33A1,DCTPP1,ST3GAL2,DNMT3A,LARGE1,PKLR,MCCC2,B3GALNT2,RFK,POLR3B,NDST1,ACY1,PRIM2,ATP6V1G1,AGPAT3,RPN1,THTPA,GALK1,MTHFS,NME1-NME2,POLR2D,MGAT5,PLCB1,INPP4A,FAHD1,LAMA5,BCAT2,AHCY,PIGU,PANK3,ALDH1B1,TST,CERS4,ACSS1,SCLY,ENOPH1,SARDH,APRT,B3GNT3,B3GALT1,NT5C2,STT3B,XYLB,SPHK2,NAMPT,ITPKA,GALM,PPT2,SLC27A5,ATP6V0C,ALLC,DHODH,ALG1,PIGN,FASN,H6PD,ACSM2B,COQ2,MTMR4,NAGLU,ALDH2,PMVK,ABAT,PANK2,ATIC,DAD1,DSE,ACSL5,MTHFD1L,COX15,ATP6V1E2,MAT2A,SPR,B4GALT4,PISD,PRDX6,ADK,PIP5KL1,UPP2,PTDSS2,CRYL1,XYLT2,MVK,NDUFB9,G6PC3,MTMR2,UCKL1,TYMP,HAAO,DEGS2,ANPEP,PGM2,PAPSS2,LDHA,PIGF,GPT2,P4HA2,ST3GAL1,B4GALNT4,FUT9,EARS2,BDH1,UPP1,PCYT2,TALDO1,NDUFB2,ACO2,MAN1A1,B4GALT3,NDUFAB1,HADHB,PLCD3,CYCS,BLVRA,GPAT2,SYNJ2,PIGW,DHRS4,KHK,GLDC,GOT2,ATP5F1D,ATP5MC3,POLG2,IDH1,KYAT1,CDS2,TAT,PNPO,AGMAT,CHPF,LPIN3,POLR2A,AMD1,MTHFD2,NFS1,ATP5PF,DGAT1,MGAT4A,SMPD1,AMDHD1,AMT,PAPSS1,POLR1C,B4GALT2,LDHAL6B,TM7SF2,GCLC,TCIRG1,COX4I1,CHKA,PIGO,PGD,ATP5F1B,UGP2,PDXP hsa00270 |Cysteine and methionine metabolism |9.35523254649708e-05|-9.27698964756306|44 |17 |0.0159924741298213 |1063 |7161 |LDHA,TST,TAT,AHCY,DNMT3B,MRI1,GOT2,BCAT2,DNMT3A,LDHAL6B,GCLC,MAT1A,GSS,AMD1,ENOPH1,ADI1,MAT2A ko00270 |Cysteine and methionine metabolism |9.35523254649708e-05|-9.27698964756306|44 |17 |0.0159924741298213 |1063 |7161 |MAT2A,ENOPH1,AMD1,ADI1,MAT1A,GSS,MRI1,GOT2,BCAT2,DNMT3A,LDHAL6B,GCLC,TST,TAT,LDHA,DNMT3B,AHCY ko04216 |Ferroptosis |0.000352753992752993|-7.94973964836418|40 |15 |0.0141110065851364 |1063 |7161 |ACSL6,ATG5,TFRC,GSS,NCOA4,HMOX1,STEAP3,TF,VDAC2,GCLC,GPX4,FTH1,CP,FTL,ACSL5 hsa04216 |Ferroptosis |0.000352753992752993|-7.94973964836418|40 |15 |0.0141110065851364 |1063 |7161 |STEAP3,TF,VDAC2,CP,GPX4,GCLC,FTH1,FTL,ACSL5,ACSL6,ATG5,TFRC,GSS,NCOA4,HMOX1 hsa04915 |Estrogen signaling pathway |0.00377871960651877 |-5.57837005516626|98 |25 |0.0235183443085607 |1063 |7161 |SOS1,ATF6B,SP1,FKBP4,HSP90AB1,FKBP5,CALML3,PIK3R1,GABBR1,PRKACA,SRC,GPER1,ATF4,JUN,GRB2,SHC2,MMP9,GNAI3,PRKCD,ITPR3,CREB3L2,PLCB1,ADCY4,ATF2,CREB1 ko04915 |Estrogen signaling pathway |0.00377871960651877 |-5.57837005516626|98 |25 |0.0235183443085607 |1063 |7161 |SOS1,SP1,ATF6B,CALML3,FKBP4,FKBP5,HSP90AB1,GABBR1,PIK3R1,GPER1,SRC,ATF4,PRKACA,SHC2,JUN,GRB2,MMP9,GNAI3,PRKCD,ITPR3,ADCY4,PLCB1,CREB3L2,CREB1,ATF2 ko05212 |Pancreatic cancer |0.00438762603196522 |-5.42896696536848|64 |18 |0.0169332079021637 |1063 |7161 |PIK3R1,TGFA,RALB,RALBP1,CDKN2A,MAPK9,BCL2L1,TGFBR2,PLD1,CDK6,CDK4,RALGDS,RELA,VEGFA,E2F1,STAT1,ERBB2,E2F3 hsa05212 |Pancreatic cancer |0.00438762603196522 |-5.42896696536848|64 |18 |0.0169332079021637 |1063 |7161 |VEGFA,E2F1,STAT1,ERBB2,E2F3,CDK4,RALGDS,RELA,MAPK9,BCL2L1,TGFBR2,PLD1,CDK6,PIK3R1,TGFA,RALB,RALBP1,CDKN2A ko04144 |Endocytosis |0.00538157745946119 |-5.22477373970724|260 |54 |0.0507996237064911 |1063 |7161 |ASAP3,CYTH1,SH3GLB1,IST1,RBSN,ARRB1,ARF3,SRC,GRK3,STAM2,EPN1,BIN1,HLA-E,PSD,ARFGEF2,AP2M1,TGFBR2,TFRC,ERBB3,VPS4A,WIPF2,SNX6,MVB12A,WASHC4,CHMP3,RAB5B,CHMP6,EHD1,SH3GL1,F2R,ARAP1,DNM2,PARD6B,RNF41,RAB11FIP5,ITCH,ARF6,CHMP4A,IGF1R,RAB11FIP1,EPN3,PDCD6IP,CYTH2,ARFGAP3,PSD4,PLD1,CHMP4B,SNX5,FGFR3,RAB11FIP4,CLTC,PIP5KL1,VPS36,RAB10 hsa04144 |Endocytosis |0.00538157745946119 |-5.22477373970724|260 |54 |0.0507996237064911 |1063 |7161 |RAB10,VPS36,PIP5KL1,CLTC,RAB11FIP4,FGFR3,SNX5,CHMP4B,PLD1,PSD4,ARFGAP3,CYTH2,PDCD6IP,EPN3,RAB11FIP1,IGF1R,ARF6,CHMP4A,ITCH,RAB11FIP5,RNF41,PARD6B,DNM2,ARAP1,SH3GL1,F2R,CHMP6,EHD1,RAB5B,CHMP3,WASHC4,MVB12A,SNX6,WIPF2,VPS4A,ERBB3,TFRC,TGFBR2,ARFGEF2,AP2M1,PSD,HLA-E,BIN1,EPN1,STAM2,GRK3,SRC,ARF3,RBSN,ARRB1,IST1,SH3GLB1,CYTH1,ASAP3 ko04668 |TNF signaling pathway |0.00724723482371508 |-4.92713528649392|108 |26 |0.0244590780809031 |1063 |7161 |CX3CL1,CEBPB,CXCL2,DNM1L,CREB3L2,MMP14,ATF2,CREB1,RELA,JAG1,MMP9,JUN,CCL20,BCL3,MAP2K7,NFKBIA,PIK3R1,CASP10,ITCH,CFLAR,ATF4,MAPK14,RIPK1,MAP3K5,MAPK9,ATF6B hsa04668 |TNF signaling pathway |0.00724723482371508 |-4.92713528649392|108 |26 |0.0244590780809031 |1063 |7161 |MAP3K5,MAPK9,ATF6B,ITCH,RIPK1,MAPK14,CFLAR,ATF4,PIK3R1,CASP10,BCL3,NFKBIA,MAP2K7,JUN,MMP9,CCL20,RELA,CREB1,ATF2,JAG1,DNM1L,MMP14,CREB3L2,CXCL2,CEBPB,CX3CL1 ko05016 |Huntington's disease |0.00935694815857448 |-4.67163609309331|187 |40 |0.0376293508936971 |1063 |7161 |VDAC2,POLR2A,SP1,TGM2,CLTC,ATP5PF,PPARG,NDUFS5,NDUFA7,NDUFB9,POLR2D,CREB3L2,PLCB1,COX4I1,CREB1,DNAH3,HDAC2,ATP5F1B,PPARGC1A,COX4I2,TFAM,AP2M1,NDUFS7,RCOR1,DNAH7,NDUFB2,ATP5MC1,DNAH17,TBP,NDUFAB1,NDUFS6,CYCS,UQCRC2,ATP5MC2,ATP5MC3,ATP5F1D,COX5B,NDUFV2,TAF4,SOD2 hsa05016 |Huntington's disease |0.00935694815857448 |-4.67163609309331|187 |40 |0.0376293508936971 |1063 |7161 |CYCS,UQCRC2,ATP5MC2,ATP5MC3,ATP5F1D,COX5B,NDUFV2,TAF4,SOD2,TFAM,AP2M1,NDUFS7,RCOR1,DNAH7,ATP5MC1,NDUFB2,DNAH17,TBP,NDUFAB1,NDUFS6,NDUFS5,NDUFA7,POLR2D,NDUFB9,PLCB1,CREB3L2,COX4I1,CREB1,DNAH3,HDAC2,ATP5F1B,PPARGC1A,COX4I2,VDAC2,POLR2A,SP1,ATP5PF,CLTC,TGM2,PPARG hsa01522 |Endocrine resistance |0.0103899285289372 |-4.5669183527265 |95 |23 |0.0216368767638758 |1063 |7161 |MAPK14,GPER1,SRC,CDKN2A,IGF1R,PRKACA,PIK3R1,MAPK9,SP1,NCOA3,SOS1,JAG1,CARM1,CDK4,ADCY4,MED1,E2F1,ERBB2,E2F3,MMP9,SHC2,GRB2,JUN ko01522 |Endocrine resistance |0.0103899285289372 |-4.5669183527265 |95 |23 |0.0216368767638758 |1063 |7161 |JUN,SHC2,GRB2,MMP9,E2F1,MED1,E2F3,ERBB2,CDK4,ADCY4,JAG1,CARM1,NCOA3,SOS1,SP1,MAPK9,PIK3R1,SRC,GPER1,MAPK14,PRKACA,IGF1R,CDKN2A ko03050 |Proteasome |0.0114187558079764 |-4.47249802920304|45 |13 |0.0122295390404516 |1063 |7161 |PSMB3,PSMC5,PSMD14,PSMF1,PSMB11,PSMD7,PSMD3,PSMD1,ADRM1,PSMD12,PSMB10,PSMA6,PSME3 hsa03050 |Proteasome |0.0114187558079764 |-4.47249802920304|45 |13 |0.0122295390404516 |1063 |7161 |PSMB10,PSMA6,PSME3,PSMD12,ADRM1,PSMD1,PSMD7,PSMD3,PSMF1,PSMD14,PSMB11,PSMB3,PSMC5 ko05219 |Bladder cancer |0.0133064445735101 |-4.31950680671375|41 |12 |0.0112888052681091 |1063 |7161 |CDK4,CDKN2A,SRC,TYMP,UPK3A,MMP9,VEGFA,FGFR3,E2F3,ERBB2,THBS1,E2F1 hsa05219 |Bladder cancer |0.0133064445735101 |-4.31950680671375|41 |12 |0.0112888052681091 |1063 |7161 |CDKN2A,TYMP,SRC,CDK4,THBS1,ERBB2,E2F3,E2F1,MMP9,UPK3A,VEGFA,FGFR3 hsa00190 |Oxidative phosphorylation |0.0156466651813692 |-4.15749747215478|120 |27 |0.0253998118532455 |1063 |7161 |NDUFB9,TCIRG1,NDUFS5,UQCRC2,NDUFA7,COX4I1,ATP5F1D,ATP5MC3,ATP5MC2,ATP6V0C,COX5B,NDUFV2,COX4I2,ATP6V1B2,ATP5F1B,ATP6V0D1,NDUFS7,ATP6V1E2,COX15,NDUFB2,ATP5MC1,ATP5PF,NDUFS6,ATP6V1F,ATP6V1G1,ATP5ME,NDUFAB1 ko00190 |Oxidative phosphorylation |0.0156466651813692 |-4.15749747215478|120 |27 |0.0253998118532455 |1063 |7161 |ATP5F1B,COX4I2,ATP6V1B2,COX5B,NDUFV2,ATP5MC2,ATP6V0C,COX4I1,ATP5MC3,ATP5F1D,NDUFS5,UQCRC2,NDUFA7,NDUFB9,TCIRG1,ATP6V1G1,NDUFAB1,ATP5ME,NDUFS6,ATP6V1F,ATP5MC1,NDUFB2,ATP5PF,COX15,ATP6V1E2,ATP6V0D1,NDUFS7 ko05223 |Non-small cell lung cancer |0.0195176010959121 |-3.936438600226 |58 |15 |0.0141110065851364 |1063 |7161 |RXRA,SOS1,GRB2,E2F1,STAT5A,ERBB2,E2F3,CDK6,EML4,CDK4,PIK3R1,TGFA,STAT5B,CDKN2A,RXRB hsa05223 |Non-small cell lung cancer |0.0195176010959121 |-3.936438600226 |58 |15 |0.0141110065851364 |1063 |7161 |TGFA,PIK3R1,EML4,CDK4,RXRB,CDKN2A,STAT5B,GRB2,SOS1,RXRA,CDK6,E2F3,ERBB2,STAT5A,E2F1 hsa01212 |Fatty acid metabolism |0.0197385109942944 |-3.92518367870866|48 |13 |0.0122295390404516 |1063 |7161 |FADS2,ACADM,PPT2,ACSL5,ACSL6,HADHB,ACADVL,FASN,ACOX1,PECR,FADS1,ELOVL6,HACD3 ko01212 |Fatty acid metabolism |0.0197385109942944 |-3.92518367870866|48 |13 |0.0122295390404516 |1063 |7161 |FASN,ACADVL,FADS1,ELOVL6,HACD3,PECR,ACOX1,ACSL6,HADHB,ACSL5,PPT2,ACADM,FADS2 ko04137 |Mitophagy - animal |0.022157426249327 |-3.80958256783173|64 |16 |0.0150517403574788 |1063 |7161 |SRC,ATF4,CSNK2B,TFEB,SQSTM1,USP15,MAPK9,SP1,BCL2L1,GABARAPL2,RELA,ULK1,CITED2,E2F1,ATG5,JUN hsa04137 |Mitophagy - animal |0.022157426249327 |-3.80958256783173|64 |16 |0.0150517403574788 |1063 |7161 |CSNK2B,ATF4,SRC,USP15,SQSTM1,TFEB,BCL2L1,SP1,MAPK9,ULK1,RELA,GABARAPL2,CITED2,ATG5,E2F1,JUN ko05220 |Chronic myeloid leukemia |0.0280632450989448 |-3.57329456242209|71 |17 |0.0159924741298213 |1063 |7161 |E2F1,STAT5A,NFKBIA,E2F3,HDAC2,GRB2,SHC2,CTBP1,RELA,CDK4,TGFBR2,CDK6,SOS1,BCL2L1,STAT5B,CDKN2A,PIK3R1 hsa05220 |Chronic myeloid leukemia |0.0280632450989448 |-3.57329456242209|71 |17 |0.0159924741298213 |1063 |7161 |HDAC2,GRB2,SHC2,E2F1,NFKBIA,STAT5A,E2F3,CDK4,CTBP1,RELA,SOS1,BCL2L1,TGFBR2,CDK6,PIK3R1,STAT5B,CDKN2A ko05203 |Viral carcinogenesis |0.0292756324377067 |-3.53099976639416|201 |40 |0.0376293508936971 |1063 |7161 |CDK6,GTF2E2,REL,GTF2A2,CDKN2A,STAT5B,ATF4,MAPKAPK2,YWHAG,USP7,GTF2H1,STAT5A,NFKBIA,JUN,HIST1H4C,HDAC2,RELA,ATF2,CREB1,RBL1,CREB3L2,DLG1,C3,CDK4,DNAJA3,LTBR,HDAC10,TBP,IRF9,ATF6B,PRKACA,SRC,PIK3R1,ATP6V0D1,HLA-E,RBL2,GSN,GRB2,HIST1H2BN,HIST1H2BI hsa05203 |Viral carcinogenesis |0.0292756324377067 |-3.53099976639416|201 |40 |0.0376293508936971 |1063 |7161 |RELA,CREB1,ATF2,RBL1,CREB3L2,C3,DLG1,CDK4,DNAJA3,USP7,YWHAG,GTF2H1,STAT5A,NFKBIA,JUN,HDAC2,HIST1H4C,GTF2A2,CDKN2A,STAT5B,MAPKAPK2,ATF4,CDK6,GTF2E2,REL,HIST1H2BN,HIST1H2BI,RBL2,GSN,GRB2,PRKACA,SRC,PIK3R1,ATP6V0D1,HLA-E,LTBR,HDAC10,TBP,IRF9,ATF6B ko04910 |Insulin signaling pathway |0.0303666380719693 |-3.49441070503233|138 |29 |0.0272812793979304 |1063 |7161 |PYGB,PIK3R1,PDE3B,SOCS1,PTPRF,PRKACA,EIF4E,PCK2,PTPN1,MAPK9,EIF4E2,PPP1R3E,SOS1,TRIP10,INSR,CALML3,PHKB,GSK3B,G6PC3,PRKAR1A,PPP1R3C,MKNK2,RPS6,PRKAR2A,PKLR,GRB2,SHC2,FASN,PPARGC1A hsa04910 |Insulin signaling pathway |0.0303666380719693 |-3.49441070503233|138 |29 |0.0272812793979304 |1063 |7161 |PTPRF,SOCS1,PRKACA,EIF4E,PYGB,PIK3R1,PDE3B,TRIP10,INSR,PHKB,CALML3,PCK2,PTPN1,MAPK9,PPP1R3E,EIF4E2,SOS1,MKNK2,PRKAR1A,G6PC3,GSK3B,PPP1R3C,PPARGC1A,RPS6,SHC2,GRB2,PKLR,PRKAR2A,FASN hsa04211 |Longevity regulating pathway |0.0346431887759128 |-3.36265414479279|89 |20 |0.0188146754468485 |1063 |7161 |EIF4E,ATF4,PRKACA,IGF1R,PIK3R1,RB1CC1,INSR,PPARG,EIF4E2,ATF6B,RELA,ULK1,ATF2,CREB1,ATG101,CREB3L2,ADCY4,PPARGC1A,SOD2,ATG5 hsa04141 |Protein processing in endoplasmic reticulum |0.0419315098276998 |-3.17171771015536|165 |33 |0.0310442144873001 |1063 |7161 |SEC63,HERPUD1,HSPA5,CKAP4,CALR,MAP2K7,RRBP1,DNAJB12,TXNDC5,DNAJA2,SEC61B,ATF4,ERLEC1,DAD1,LMAN1L,HSP90AB1,EIF2AK1,RPN1,MAPK9,UGGT1,BAG2,WFS1,NFE2L2,RAD23B,MBTPS1,DERL1,EDEM2,UBE2J2,STT3B,MAN1A1,HYOU1,MAP3K5,ATF6B ko04141 |Protein processing in endoplasmic reticulum |0.0419315098276998 |-3.17171771015536|165 |33 |0.0310442144873001 |1063 |7161 |RPN1,HSP90AB1,EIF2AK1,MAPK9,DNAJA2,ATF4,SEC61B,ERLEC1,DNAJB12,RRBP1,TXNDC5,LMAN1L,DAD1,MAP2K7,CALR,SEC63,HERPUD1,HSPA5,CKAP4,STT3B,MAN1A1,ATF6B,HYOU1,MAP3K5,EDEM2,MBTPS1,DERL1,UBE2J2,BAG2,UGGT1,NFE2L2,WFS1,RAD23B hsa04917 |Prolactin signaling pathway |0.047880273912618 |-3.03905167749382|70 |16 |0.0150517403574788 |1063 |7161 |SOS1,MAPK9,SOCS5,PIK3R1,SOCS1,SRC,STAT5B,MAPK14,SHC2,GRB2,IRF1,STAT1,STAT5A,GSK3B,RELA,CISH ko04917 |Prolactin signaling pathway |0.047880273912618 |-3.03905167749382|70 |16 |0.0150517403574788 |1063 |7161 |IRF1,STAT1,STAT5A,SHC2,GRB2,CISH,RELA,GSK3B,SOS1,MAPK9,STAT5B,SRC,MAPK14,SOCS1,SOCS5,PIK3R1 hsa05161 |Hepatitis B |0.0499300135851093 |-2.99713298238655|144 |29 |0.0272812793979304 |1063 |7161 |MMP9,JUN,GRB2,BIRC5,E2F3,E2F1,STAT5A,NFKBIA,STAT1,STAT6,CREB3L2,CYCS,NFATC3,CDK4,ATF2,CREB1,RELA,NFATC2,ATF6B,MAPK9,CDK6,NFATC4,PIK3R1,CASP10,ATF4,PTK2B,LAMTOR5,SRC,STAT5B ko00240 |Pyrimidine metabolism |0.0508440599846644 |-2.97899197777179|104 |22 |0.0206961429915334 |1063 |7161 |NME2,POLR2A,POLR3B,UPP1,POLR1C,PRIM2,NT5C2,POLR3E,UPP2,NT5C,UCKL1,DHODH,TYMP,DCTPP1,POLE2,NME1,NME1-NME2,POLR2D,POLR1D,TYMS,ENTPD5,ENTPD6 hsa00240 |Pyrimidine metabolism |0.0508440599846644 |-2.97899197777179|104 |22 |0.0206961429915334 |1063 |7161 |NME1,POLE2,DCTPP1,DHODH,TYMP,UCKL1,NME1-NME2,POLR2D,TYMS,POLR1D,ENTPD6,ENTPD5,POLR2A,NME2,POLR3B,UPP1,PRIM2,NT5C2,POLR1C,NT5C,UPP2,POLR3E ko04510 |Focal adhesion |0.0536253156772137 |-2.92573401499672|198 |38 |0.0357478833490122 |1063 |7161 |LAMA5,ROCK2,ITGB5,VAV2,THBS2,ACTG1,ERBB2,PDGFB,THBS1,JUN,VEGFA,FN1,PGF,ARHGAP5,IGF1R,FLNB,ITGA1,MAPK9,RASGRF1,GSK3B,CTNNB1,PAK4,BCAR1,PPP1R12B,SHC2,GRB2,COMP,MYL12A,SRC,MYL9,ITGA6,ITGB4,PIK3R1,RELN,MYLK,PPP1R12C,VAV3,SOS1 hsa04510 |Focal adhesion |0.0536253156772137 |-2.92573401499672|198 |38 |0.0357478833490122 |1063 |7161 |JUN,VEGFA,THBS1,PDGFB,ACTG1,ERBB2,VAV2,THBS2,LAMA5,ROCK2,ITGB5,MAPK9,ITGA1,FLNB,PGF,IGF1R,ARHGAP5,FN1,GRB2,SHC2,PPP1R12B,BCAR1,PAK4,GSK3B,CTNNB1,RASGRF1,SOS1,VAV3,PPP1R12C,MYLK,RELN,ITGB4,PIK3R1,SRC,ITGA6,MYL9,COMP,MYL12A hsa04022 |cGMP-PKG signaling pathway |0.0556117915920469 |-2.88936002121752|163 |32 |0.0301034807149577 |1063 |7161 |PDE3B,VDAC2,MEF2D,RGS2,ATF4,ATP2B2,INSR,ADRA1D,NFATC3,GTF2I,ADCY4,PLCB1,CREB3L2,ROCK2,ATF2,ADRA2C,CREB1,NPPB,ITPR3,ADRA2B,MYL9,MEF2B,ATF6B,NFATC2,MYLK,CALML3,NFATC4,GNA13,PRKCE,GATA4,SLC8A3,GNAI3 ko04022 |cGMP-PKG signaling pathway |0.0556117915920469 |-2.88936002121752|163 |32 |0.0301034807149577 |1063 |7161 |MYL9,MEF2B,NFATC2,ATF6B,MYLK,NFATC4,CALML3,GNA13,GATA4,PRKCE,SLC8A3,GNAI3,MEF2D,PDE3B,VDAC2,RGS2,ATF4,ATP2B2,INSR,ADRA1D,GTF2I,PLCB1,ADCY4,CREB3L2,NFATC3,ADRA2C,CREB1,ATF2,ROCK2,NPPB,ADRA2B,ITPR3 ko05169 |Epstein-Barr virus infection |0.0571862072257047 |-2.86144254209123|199 |38 |0.0357478833490122 |1063 |7161 |USP7,YWHAG,POLR1D,MAP2K7,NFKBIA,HDAC2,JUN,NFKBIB,ATF2,RELA,XPO1,POLR2D,NCOR2,EIF2AK1,POLR1C,GTF2E2,POLR3E,MAPK9,AKAP8L,PSMD1,CSNK2B,MAPK14,POLR2A,RIPK1,POLR3B,PTMA,PSMD12,GSK3B,PSMC5,TBP,PSMD14,PSMD3,PSMD7,HSPB1,PRKACA,ADRM1,PIK3R1,HLA-E hsa05169 |Epstein-Barr virus infection |0.0571862072257047 |-2.86144254209123|199 |38 |0.0357478833490122 |1063 |7161 |JUN,NFKBIB,HDAC2,POLR1D,USP7,YWHAG,NFKBIA,MAP2K7,POLR2D,NCOR2,RELA,ATF2,XPO1,POLR3E,AKAP8L,MAPK9,POLR1C,EIF2AK1,GTF2E2,POLR3B,PSMD1,POLR2A,RIPK1,MAPK14,CSNK2B,GSK3B,PTMA,PSMD12,TBP,PSMD14,HSPB1,PSMD7,PSMD3,PSMC5,PIK3R1,HLA-E,PRKACA,ADRM1 hsa04931 |Insulin resistance |0.066318068620505 |-2.71329289070664|107 |22 |0.0206961429915334 |1063 |7161 |PRKCD,PPARGC1A,NFKBIA,CREB1,RELA,SLC27A5,PRKCE,TRIB3,CREB3L2,G6PC3,GSK3B,PPP1R3C,MLX,INSR,PCK2,PTPN1,PPP1R3E,MAPK9,PTPRF,GFPT1,PYGB,PIK3R1 hsa04659 |Th17 cell differentiation |0.066318068620505 |-2.71329289070664|107 |22 |0.0206961429915334 |1063 |7161 |NFATC3,STAT6,IL27RA,IRF4,RXRB,RELA,RXRA,ZAP70,NFKBIB,JUN,STAT5A,STAT1,NFKBIA,MAPK14,STAT5B,RARA,MAPK9,IL23A,IL1R1,NFATC2,TGFBR2,HSP90AB1 ko04659 |Th17 cell differentiation |0.066318068620505 |-2.71329289070664|107 |22 |0.0206961429915334 |1063 |7161 |NFKBIA,STAT1,STAT5A,RXRA,NFKBIB,JUN,ZAP70,IRF4,RXRB,RELA,NFATC3,STAT6,IL27RA,TGFBR2,HSP90AB1,IL1R1,IL23A,MAPK9,NFATC2,STAT5B,MAPK14,RARA hsa01521 |EGFR tyrosine kinase inhibitor resistance |0.069316972734607 |-2.66906548596821|79 |17 |0.0159924741298213 |1063 |7161 |BCL2L1,EIF4E2,ERBB3,FGFR3,SOS1,IGF1R,SRC,EIF4E,PIK3R1,TGFA,PDGFB,ERBB2,RPS6,VEGFA,GRB2,SHC2,GSK3B ko01521 |EGFR tyrosine kinase inhibitor resistance |0.069316972734607 |-2.66906548596821|79 |17 |0.0159924741298213 |1063 |7161 |GSK3B,GRB2,SHC2,RPS6,VEGFA,ERBB2,PDGFB,TGFA,PIK3R1,IGF1R,EIF4E,SRC,BCL2L1,FGFR3,SOS1,ERBB3,EIF4E2 hsa04660 |T cell receptor signaling pathway |0.0707391676296881 |-2.64875586188856|102 |21 |0.019755409219191 |1063 |7161 |NCK2,GRB2,NFKBIB,JUN,ZAP70,NFKBIA,MAP2K7,PAK4,CD28,CDK4,NFATC3,GSK3B,VAV2,DLG1,RELA,VAV3,SOS1,MAPK9,NFATC2,PIK3R1,MAPK14 hsa04922 |Glucagon signaling pathway |0.0707391676296881 |-2.64875586188856|102 |21 |0.019755409219191 |1063 |7161 |PCK2,PHKB,CALML3,PYGB,PDE3B,PRKACA,PPP4R3A,PPP4C,ATF4,ITPR3,PPARGC1A,LDHA,PLCB1,G6PC3,CREB3L2,GCGR,LDHAL6B,ATF2,CREB1,PFKL,PRMT1 ko04660 |T cell receptor signaling pathway |0.0707391676296881 |-2.64875586188856|102 |21 |0.019755409219191 |1063 |7161 |DLG1,VAV2,GSK3B,CDK4,NFATC3,RELA,ZAP70,GRB2,NFKBIB,JUN,NCK2,CD28,PAK4,MAP2K7,NFKBIA,PIK3R1,MAPK14,NFATC2,MAPK9,VAV3,SOS1 ko04922 |Glucagon signaling pathway |0.0707391676296881 |-2.64875586188856|102 |21 |0.019755409219191 |1063 |7161 |PCK2,CALML3,PHKB,PYGB,PDE3B,PRKACA,PPP4R3A,ATF4,PPP4C,ITPR3,PPARGC1A,LDHA,PLCB1,CREB3L2,G6PC3,LDHAL6B,GCGR,PFKL,ATF2,CREB1,PRMT1 hsa05215 |Prostate cancer |0.0860744813686868 |-2.45254229511771|87 |18 |0.0169332079021637 |1063 |7161 |RELA,CREB1,CREB3L2,GSK3B,CTNNB1,E2F3,ERBB2,PDGFB,NFKBIA,TCF7L2,E2F1,GRB2,IGF1R,ATF4,TGFA,PIK3R1,HSP90AB1,SOS1 ko05215 |Prostate cancer |0.0860744813686868 |-2.45254229511771|87 |18 |0.0169332079021637 |1063 |7161 |GRB2,ERBB2,PDGFB,E2F3,TCF7L2,E2F1,NFKBIA,CTNNB1,GSK3B,CREB3L2,CREB1,RELA,SOS1,HSP90AB1,PIK3R1,TGFA,IGF1R,ATF4 ko04662 |B cell receptor signaling pathway |0.0868872277833703 |-2.44314423353848|70 |15 |0.0141110065851364 |1063 |7161 |CD79B,RELA,NFATC3,GSK3B,VAV2,INPP5D,PIK3R1,PIK3AP1,NFKBIA,SOS1,VAV3,GRB2,JUN,NFKBIB,NFATC2 hsa04662 |B cell receptor signaling pathway |0.0868872277833703 |-2.44314423353848|70 |15 |0.0141110065851364 |1063 |7161 |INPP5D,PIK3R1,VAV2,GSK3B,NFATC3,RELA,CD79B,NFATC2,JUN,GRB2,NFKBIB,VAV3,SOS1,PIK3AP1,NFKBIA ko03010 |Ribosome |0.0876834383803629 |-2.43402224144682|134 |26 |0.0244590780809031 |1063 |7161 |MRPL27,RPS14,RPS27A,MRPL33,RPS28,MRPS5,RPS7,RPL29,MRPL19,RPL31,RPL27,MRPS18A,MRPL17,MRPL12,MRPS9,RPL9,RPL37A,UBA52,RPL18,RPS21,RPS6,RPS16,MRPL18,RPS26,RPL23,RPS15A hsa03010 |Ribosome |0.0876834383803629 |-2.43402224144682|134 |26 |0.0244590780809031 |1063 |7161 |MRPL12,RPL9,MRPS9,RPL37A,UBA52,RPL18,RPS21,RPS6,RPS16,MRPL18,RPS26,RPL23,RPS15A,MRPL27,MRPL33,RPS27A,RPS14,MRPS5,RPS28,RPL29,RPS7,MRPL19,RPL31,RPL27,MRPS18A,MRPL17 hsa04530 |Tight junction |0.0885482328493717 |-2.42420787148126|170 |32 |0.0301034807149577 |1063 |7161 |LLGL2,MAPK9,MYH9,F11R,JUN,TUBA4A,MAP2K7,ACTG1,ERBB2,CDK4,PARD6B,DLG1,MPP4,TUBA1C,ROCK2,CGNL1,AFDN,MAP3K5,CLDN19,RAB8B,ACTR3B,ACTR3,HSPA4,SRC,MYL9,PRKACA,MYL12A,SYNPO,MICALL2,PPP2CA,PRKCE,GATA4 ko04530 |Tight junction |0.0885482328493717 |-2.42420787148126|170 |32 |0.0301034807149577 |1063 |7161 |AFDN,CGNL1,ROCK2,DLG1,MPP4,TUBA1C,PARD6B,CDK4,ACTG1,ERBB2,MAP2K7,TUBA4A,JUN,F11R,MYH9,MAPK9,LLGL2,GATA4,PPP2CA,PRKCE,MICALL2,SYNPO,MYL12A,PRKACA,MYL9,SRC,HSPA4,ACTR3,RAB8B,ACTR3B,CLDN19,MAP3K5 hsa04142 |Lysosome |0.0931042954827616 |-2.37403495738793|123 |24 |0.0225776105362183 |1063 |7161 |AP3M2,GAA,CTSB,AP4S1,LITAF,GGA3,ATP6V0D1,SMPD1,MANBA,LAPTM4A,IDUA,PLA2G15,GGA2,CLTC,SUMF1,CTSZ,CD68,AP1S3,AP1G2,ATP6V0C,PPT2,TCIRG1,NAGLU,FUCA1 ko04142 |Lysosome |0.0931042954827616 |-2.37403495738793|123 |24 |0.0225776105362183 |1063 |7161 |TCIRG1,PPT2,AP1G2,ATP6V0C,CD68,AP1S3,FUCA1,NAGLU,ATP6V0D1,GGA3,LITAF,AP4S1,CTSB,AP3M2,GAA,CTSZ,SUMF1,CLTC,GGA2,PLA2G15,IDUA,LAPTM4A,MANBA,SMPD1 hsa05012 |Parkinson's disease |0.0936127966382413 |-2.36858818862288|129 |25 |0.0235183443085607 |1063 |7161 |PARK7,ATP5F1D,ATP5MC3,COX4I1,ATP5MC2,NDUFB9,NDUFA7,UQCRC2,NDUFS5,CYCS,GNAI3,COX4I2,ATP5F1B,NDUFV2,COX5B,PRKACA,NDUFS7,SEPTIN5,VDAC2,UBE2J2,NDUFS6,NDUFAB1,NDUFB2,ATP5PF,ATP5MC1 hsa03018 |RNA degradation |0.0983590179542079 |-2.31913104588277|77 |16 |0.0150517403574788 |1063 |7161 |SKIV2L,LSM2,TOB2,TOB1,XRN2,HSPD1,WDR61,LSM5,DCP1B,LSM4,PABPC1L,ENO1,EXOSC6,EDC4,DCP1A,PFKL ko03018 |RNA degradation |0.0983590179542079 |-2.31913104588277|77 |16 |0.0150517403574788 |1063 |7161 |LSM2,SKIV2L,XRN2,TOB2,TOB1,HSPD1,WDR61,LSM5,DCP1B,LSM4,ENO1,EXOSC6,EDC4,PABPC1L,DCP1A,PFKL hsa00510 |N-Glycan biosynthesis |0.100725519806474 |-2.29535608726802|49 |11 |0.0103480714957667 |1063 |7161 |RPN1,B4GALT3,STT3B,MAN1A1,MGAT4A,MGAT1,ALG1,MGAT5,DAD1,B4GALT2,ALG2 hsa00330 |Arginine and proline metabolism |0.100725519806474 |-2.29535608726802|49 |11 |0.0103480714957667 |1063 |7161 |ALDH1B1,AGMAT,ALDH2,P4HA2,OAT,DAO,L3HYPDH,GOT2,AMD1,SMOX,ODC1 ko00330 |Arginine and proline metabolism |0.100725519806474 |-2.29535608726802|49 |11 |0.0103480714957667 |1063 |7161 |P4HA2,OAT,AGMAT,ALDH2,ALDH1B1,SMOX,ODC1,GOT2,AMD1,L3HYPDH,DAO ko00510 |N-Glycan biosynthesis |0.100725519806474 |-2.29535608726802|49 |11 |0.0103480714957667 |1063 |7161 |B4GALT3,RPN1,STT3B,MGAT4A,MAN1A1,MGAT1,ALG1,B4GALT2,ALG2,MGAT5,DAD1 hsa04520 |Adherens junction |0.105243000721637 |-2.2514833100881 |72 |15 |0.0141110065851364 |1063 |7161 |PTPN1,ERBB2,ACTG1,TGFBR2,INSR,TCF7L2,CTNNB1,WASF2,IGF1R,AFDN,ACP1,PTPRF,FARP2,SRC,CSNK2B ko04520 |Adherens junction |0.105243000721637 |-2.2514833100881 |72 |15 |0.0141110065851364 |1063 |7161 |INSR,TCF7L2,TGFBR2,ERBB2,ACTG1,PTPN1,CSNK2B,FARP2,SRC,AFDN,ACP1,PTPRF,IGF1R,WASF2,CTNNB1 ko00230 |Purine metabolism |0.106036181527298 |-2.24397490794847|173 |32 |0.0301034807149577 |1063 |7161 |PAPSS1,POLR1C,PRIM2,ADK,POLR3E,PRUNE1,POLR2A,ATIC,PDE4D,POLR3B,PDE3B,GUK1,POLR1D,PGM2,PAPSS2,ENTPD6,PDE7A,POLE2,NME1-NME2,POLR2D,ADCY4,ITPA,NT5C2,GMPR2,NT5C,APRT,NME2,NUDT9,PKLR,ENTPD5,NME1,ALLC hsa00230 |Purine metabolism |0.106036181527298 |-2.24397490794847|173 |32 |0.0301034807149577 |1063 |7161 |ITPA,ADCY4,POLR2D,NME1-NME2,POLE2,PDE7A,ENTPD6,PAPSS2,PGM2,POLR1D,GUK1,PDE3B,POLR3B,PDE4D,ATIC,POLR2A,PRUNE1,POLR3E,ADK,PRIM2,PAPSS1,POLR1C,NME1,ALLC,ENTPD5,PKLR,NUDT9,NME2,APRT,NT5C,GMPR2,NT5C2 ko04666 |Fc gamma R-mediated phagocytosis |0.110958481825617 |-2.19859918524637|90 |18 |0.0169332079021637 |1063 |7161 |DNM2,HCK,VAV2,SPHK2,PRKCE,ASAP3,SPHK1,GSN,PRKCD,PIK3R1,WASF2,INPP5D,ARF6,BIN1,VAV3,LIMK2,PLD1,CFL2 hsa04666 |Fc gamma R-mediated phagocytosis |0.110958481825617 |-2.19859918524637|90 |18 |0.0169332079021637 |1063 |7161 |ARF6,BIN1,WASF2,PIK3R1,INPP5D,PLD1,LIMK2,CFL2,VAV3,ASAP3,PRKCE,SPHK2,DNM2,VAV2,HCK,GSN,PRKCD,SPHK1 ko03040 |Spliceosome |0.11474291097927 |-2.16506120990825|132 |25 |0.0235183443085607 |1063 |7161 |LSM2,SF3B6,ACIN1,EIF4A3,DDX42,TXNL4A,SNRPB2,LSM5,EFTUD2,DDX46,PUF60,HNRNPA3,CRNKL1,SNRNP200,CHERP,DHX8,LSM4,SRSF8,SNRPC,SRSF10,SNRPA,SNRPB,SRSF6,PRPF31,PRPF6 hsa03040 |Spliceosome |0.11474291097927 |-2.16506120990825|132 |25 |0.0235183443085607 |1063 |7161 |SRSF8,SNRPC,DHX8,LSM4,PUF60,DDX46,HNRNPA3,SNRNP200,CRNKL1,CHERP,EFTUD2,PRPF6,PRPF31,SNRPA,SNRPB,SRSF6,SRSF10,ACIN1,LSM2,SF3B6,TXNL4A,LSM5,SNRPB2,DDX42,EIF4A3 ko05120 |Epithelial cell signaling in Helicobacter pylori infection|0.123573128282436 |-2.0909221663134 |68 |14 |0.013170272812794 |1063 |7161 |SRC,ATP6V0C,MAPK14,RELA,ATP6V1E2,TCIRG1,ATP6V0D1,F11R,NFKBIA,ATP6V1G1,ATP6V1F,ATP6V1B2,MAPK9,JUN hsa05120 |Epithelial cell signaling in Helicobacter pylori infection|0.123573128282436 |-2.0909221663134 |68 |14 |0.013170272812794 |1063 |7161 |ATP6V1E2,RELA,MAPK14,ATP6V0C,SRC,ATP6V0D1,TCIRG1,ATP6V1B2,ATP6V1F,ATP6V1G1,F11R,NFKBIA,JUN,MAPK9 hsa04912 |GnRH signaling pathway |0.129759679739821 |-2.0420711567144 |92 |18 |0.0169332079021637 |1063 |7161 |MAP2K7,PRKCD,ITPR3,JUN,GRB2,PLCB1,ADCY4,MMP14,CALML3,PLD1,GNRH2,MAPK9,SOS1,PTK2B,ATF4,MAPK14,SRC,PRKACA ko04912 |GnRH signaling pathway |0.129759679739821 |-2.0420711567144 |92 |18 |0.0169332079021637 |1063 |7161 |PLD1,CALML3,SOS1,GNRH2,MAPK9,PRKACA,SRC,PTK2B,ATF4,MAPK14,ITPR3,PRKCD,MAP2K7,JUN,GRB2,PLCB1,MMP14,ADCY4 ko04721 |Synaptic vesicle cycle |0.132638184522129 |-2.02013027494659|63 |13 |0.0122295390404516 |1063 |7161 |SLC17A7,ATP6V1E2,STX1B,ATP6V0C,AP2M1,CPLX2,TCIRG1,DNM2,ATP6V0D1,ATP6V1F,ATP6V1B2,ATP6V1G1,CLTC hsa04721 |Synaptic vesicle cycle |0.132638184522129 |-2.02013027494659|63 |13 |0.0122295390404516 |1063 |7161 |CLTC,ATP6V1G1,ATP6V1B2,ATP6V1F,ATP6V0D1,DNM2,AP2M1,TCIRG1,CPLX2,STX1B,ATP6V0C,SLC17A7,ATP6V1E2 ko05214 |Glioma |0.145141041326498 |-1.93004931052306|64 |13 |0.0122295390404516 |1063 |7161 |IGF1R,CDKN2A,TGFA,PIK3R1,CDK4,CDK6,E2F3,PDGFB,CALML3,E2F1,GRB2,SHC2,SOS1 hsa05214 |Glioma |0.145141041326498 |-1.93004931052306|64 |13 |0.0122295390404516 |1063 |7161 |CDK4,TGFA,PIK3R1,IGF1R,CDKN2A,SOS1,SHC2,GRB2,CALML3,E2F1,E2F3,CDK6,PDGFB hsa05200 |Pathways in cancer |0.158690941711414 |-1.84079673114171|395 |66 |0.0620884289746002 |1063 |7161 |BCL2L1,SOS1,TGFBR2,GSK3B,CYCS,RXRB,EPAS1,STAT1,TGFA,GNGT2,ARHGEF1,PGF,IGF1R,RALBP1,STAT5B,FGFR3,PPARG,CEBPA,HSP90AB1,FGF17,PLCB1,ADCY4,CDK4,SHH,F2R,RELA,LAMA5,RALGDS,JUP,JUN,HDAC2,VEGFA,NCOA4,ERBB2,STAT5A,GNB1,E2F1,PIK3R1,RARA,PRKACA,GNB5,ITGA6,CTNNB1,GNA13,AXIN2,EGLN3,GRB2,FZD5,WNT11,RXRA,GNAI3,E2F3,TCF7L2,RALB,FN1,CDKN2A,MAPK9,CDK6,PLD1,CSF3R,CTBP1,ROCK2,MMP9,BIRC5,PDGFB,NFKBIA ko04722 |Neurotrophin signaling pathway |0.158988044142424 |-1.83892627366193|119 |22 |0.0206961429915334 |1063 |7161 |GRB2,ARHGDIA,SHC2,NFKBIB,JUN,NFKBIA,MAP2K7,PRKCD,GSK3B,RELA,SOS1,MAPK9,ZNF274,MAP3K5,IRAK2,CALML3,PSEN2,NGFR,PIK3R1,MAPK14,MAPKAPK2,ATF4 hsa04722 |Neurotrophin signaling pathway |0.158988044142424 |-1.83892627366193|119 |22 |0.0206961429915334 |1063 |7161 |MAPKAPK2,ATF4,MAPK14,PIK3R1,PSEN2,NGFR,CALML3,ZNF274,MAP3K5,IRAK2,SOS1,MAPK9,RELA,GSK3B,PRKCD,NFKBIA,MAP2K7,JUN,NFKBIB,SHC2,GRB2,ARHGDIA hsa04146 |Peroxisome |0.161109215068754 |-1.82567278951175|83 |16 |0.0150517403574788 |1063 |7161 |DHRS4L1,ACOX1,DECR2,ACSL6,MVK,PMVK,DAO,ACSL5,PEX16,GNPAT,IDH1,PECR,ABCD3,SOD2,PRDX5,DHRS4 ko04146 |Peroxisome |0.161109215068754 |-1.82567278951175|83 |16 |0.0150517403574788 |1063 |7161 |PRDX5,DHRS4,PECR,IDH1,GNPAT,SOD2,ABCD3,ACSL5,DAO,PMVK,PEX16,ACOX1,DHRS4L1,MVK,DECR2,ACSL6 hsa00564 |Glycerophospholipid metabolism |0.161212696503363 |-1.8250306895834 |95 |18 |0.0169332079021637 |1063 |7161 |GPD1L,CHKA,GPAT2,GPCPD1,GPD2,CDS2,LCAT,PNPLA6,AGPAT1,GNPAT,PCYT2,PISD,CRLS1,LPIN3,PLD1,PTDSS2,AGPAT3,PLA2G15 ko00564 |Glycerophospholipid metabolism |0.161212696503363 |-1.8250306895834 |95 |18 |0.0169332079021637 |1063 |7161 |PLA2G15,PTDSS2,AGPAT3,PLD1,LPIN3,CRLS1,PCYT2,PISD,PNPLA6,GNPAT,AGPAT1,LCAT,CDS2,GPCPD1,GPD2,GPAT2,GPD1L,CHKA hsa04371 |Apelin signaling pathway |0.165226988643861 |-1.80043506172371|138 |25 |0.0235183443085607 |1063 |7161 |PRKCE,GABARAPL2,JAG1,EGR1,SPHK2,GNA13,ADCY4,PLCB1,GNB1,PPARGC1A,ITPR3,CCN2,GNAI3,SPHK1,RPS6,SLC8A3,MEF2B,GNB5,PRKACA,PDE3B,TFAM,GNGT2,MEF2D,MYLK,CALML3 hsa03460 |Fanconi anemia pathway |0.168363188688573 |-1.78163179555508|54 |11 |0.0103480714957667 |1063 |7161 |BRIP1,FANCA,TOP3A,FANCF,CENPX,RMI2,REV1,CENPS-CORT,FANCE,PALB2,RAD51C ko03460 |Fanconi anemia pathway |0.168363188688573 |-1.78163179555508|54 |11 |0.0103480714957667 |1063 |7161 |CENPS-CORT,PALB2,FANCE,RAD51C,RMI2,REV1,FANCF,CENPX,BRIP1,FANCA,TOP3A hsa04062 |Chemokine signaling pathway |0.171083933797467 |-1.76560100198162|182 |32 |0.0301034807149577 |1063 |7161 |CXCL16,GNGT2,STAT5B,PTK2B,HCK,VAV2,PLCB1,ADCY4,CX3CL1,PREX1,RELA,ROCK2,NFKBIB,NFKBIA,GNB1,PIK3R1,PRKACA,GNB5,SRC,GRK3,SOS1,VAV3,CXCL2,GSK3B,SHC2,GRB2,ARRB1,CCL20,GNAI3,BCAR1,PRKCD,STAT1 ko04062 |Chemokine signaling pathway |0.171083933797467 |-1.76560100198162|182 |32 |0.0301034807149577 |1063 |7161 |STAT5B,PTK2B,CXCL16,GNGT2,ROCK2,RELA,PREX1,ADCY4,PLCB1,HCK,VAV2,CX3CL1,NFKBIA,GNB1,NFKBIB,SRC,GRK3,GNB5,PRKACA,PIK3R1,SOS1,VAV3,GSK3B,CXCL2,STAT1,BCAR1,GNAI3,PRKCD,ARRB1,CCL20,SHC2,GRB2 ko03320 |PPAR signaling pathway |0.172811800845636 |-1.75555213301321|72 |14 |0.013170272812794 |1063 |7161 |APOA2,APOC3,ACSL5,CYP27A1,SLC27A5,RXRB,ACADM,FADS2,RXRA,PCK2,ACOX1,ACSL6,PLTP,PPARG hsa03320 |PPAR signaling pathway |0.172811800845636 |-1.75555213301321|72 |14 |0.013170272812794 |1063 |7161 |PCK2,ACOX1,RXRA,PPARG,ACSL6,PLTP,ACSL5,APOC3,APOA2,RXRB,ACADM,FADS2,CYP27A1,SLC27A5 ko04932 |Non-alcoholic fatty liver disease (NAFLD) |0.173061894742299 |-1.75410597539301|145 |26 |0.0244590780809031 |1063 |7161 |JUN,PKLR,NDUFV2,COX5B,RXRA,COX4I2,GSK3B,NDUFB9,NDUFA7,UQCRC2,CYCS,NDUFS5,RELA,COX4I1,MAP3K5,NDUFB2,MAPK9,MLX,NDUFS6,CEBPA,NDUFAB1,INSR,NDUFS7,PIK3R1,ITCH,ATF4 hsa04932 |Non-alcoholic fatty liver disease (NAFLD) |0.173061894742299 |-1.75410597539301|145 |26 |0.0244590780809031 |1063 |7161 |COX4I2,NDUFV2,RXRA,COX5B,JUN,PKLR,RELA,COX4I1,NDUFA7,UQCRC2,CYCS,NDUFS5,GSK3B,NDUFB9,NDUFAB1,INSR,MLX,CEBPA,NDUFS6,MAPK9,MAP3K5,NDUFB2,ATF4,ITCH,NDUFS7,PIK3R1 hsa05221 |Acute myeloid leukemia |0.184056962208877 |-1.69250999206013|55 |11 |0.0103480714957667 |1063 |7161 |PIM1,GRB2,SOS1,CEBPA,TCF7L2,STAT5A,PIK3R1,RELA,RARA,STAT5B,JUP ko05221 |Acute myeloid leukemia |0.184056962208877 |-1.69250999206013|55 |11 |0.0103480714957667 |1063 |7161 |TCF7L2,STAT5A,CEBPA,SOS1,PIM1,GRB2,STAT5B,JUP,RARA,RELA,PIK3R1 hsa_M00177|Ribosome, eukaryotes |0.185166510249247 |-1.68649980330946|91 |17 |0.0159924741298213 |1063 |7161 |RPL27,RPS27A,RPS14,RPL29,RPS7,RPS28,RPL31,RPS6,RPS16,RPS21,RPS26,RPL23,RPS15A,RPL37A,RPL9,RPL18,UBA52 M00177 |Ribosome, eukaryotes |0.185166510249247 |-1.68649980330946|91 |17 |0.0159924741298213 |1063 |7161 |RPL27,RPS27A,RPS14,RPL29,RPS7,RPS28,RPL31,RPS16,RPS6,RPS21,RPS26,RPS15A,RPL23,RPL37A,RPL9,RPL18,UBA52 hsa04012 |ErbB signaling pathway |0.185873397448308 |-1.68268949590242|85 |16 |0.0150517403574788 |1063 |7161 |TGFA,PIK3R1,SRC,STAT5B,SOS1,ERBB3,MAPK9,GSK3B,NCK2,JUN,GRB2,SHC2,STAT5A,MAP2K7,PAK4,ERBB2 ko04012 |ErbB signaling pathway |0.185873397448308 |-1.68268949590242|85 |16 |0.0150517403574788 |1063 |7161 |MAPK9,ERBB3,SOS1,PIK3R1,TGFA,STAT5B,SRC,NCK2,GRB2,SHC2,JUN,MAP2K7,STAT5A,ERBB2,PAK4,GSK3B hsa00010 |Glycolysis / Gluconeogenesis |0.186220358853429 |-1.68082458148339|67 |13 |0.0122295390404516 |1063 |7161 |PFKL,LDHAL6B,ENO1,GALM,G6PC3,LDHA,ALDH2,ACSS1,ALDH3B1,PCK2,PGM2,ALDH1B1,PKLR ko00010 |Glycolysis / Gluconeogenesis |0.186220358853429 |-1.68082458148339|67 |13 |0.0122295390404516 |1063 |7161 |ALDH1B1,PKLR,PGM2,PCK2,ALDH3B1,ACSS1,ALDH2,LDHA,G6PC3,GALM,LDHAL6B,ENO1,PFKL ko01230 |Biosynthesis of amino acids |0.200633318128797 |-1.60627632487923|74 |14 |0.013170272812794 |1063 |7161 |MAT1A,GLUL,GPT2,TAT,IDH1,ACO2,ACY1,PKLR,TALDO1,MAT2A,PFKL,BCAT2,GOT2,ENO1 hsa01230 |Biosynthesis of amino acids |0.200633318128797 |-1.60627632487923|74 |14 |0.013170272812794 |1063 |7161 |ENO1,PFKL,MAT2A,GOT2,BCAT2,IDH1,ACO2,PKLR,ACY1,TALDO1,MAT1A,GLUL,GPT2,TAT ko05418 |Fluid shear stress and atherosclerosis |0.204709597688228 |-1.58616290080813|142 |25 |0.0235183443085607 |1063 |7161 |MAP3K5,HMOX1,SDC1,TXN,IL1R1,MAPK9,HSP90AB1,TXN2,CALML3,SDC4,PIK3R1,SQSTM1,SRC,MAPK14,NFE2L2,JUN,VEGFA,MMP9,ACTG1,PDGFB,MAP2K7,CTNNB1,CYBA,RELA,KEAP1 hsa05418 |Fluid shear stress and atherosclerosis |0.204709597688228 |-1.58616290080813|142 |25 |0.0235183443085607 |1063 |7161 |MMP9,VEGFA,JUN,NFE2L2,MAP2K7,PDGFB,ACTG1,CYBA,CTNNB1,KEAP1,RELA,MAPK9,IL1R1,TXN,SDC1,HMOX1,MAP3K5,SDC4,CALML3,HSP90AB1,TXN2,SQSTM1,PIK3R1,MAPK14,SRC hsa04933 |AGE-RAGE signaling pathway in diabetic complications |0.208854663485207 |-1.56611665893605|99 |18 |0.0169332079021637 |1063 |7161 |PRKCE,EGR1,RELA,CDK4,PLCB1,STAT1,STAT5A,PRKCD,VEGFA,JUN,MAPK14,STAT5B,FN1,PIK3R1,TGFBR2,PLCD3,MAPK9,PIM1 ko04933 |AGE-RAGE signaling pathway in diabetic complications |0.208854663485207 |-1.56611665893605|99 |18 |0.0169332079021637 |1063 |7161 |CDK4,PLCB1,PRKCE,EGR1,RELA,VEGFA,JUN,STAT1,STAT5A,PRKCD,PIK3R1,MAPK14,STAT5B,FN1,MAPK9,PIM1,TGFBR2,PLCD3 hsa04115 |p53 signaling pathway |0.21634673242349 |-1.53087291562155|69 |13 |0.0122295390404516 |1063 |7161 |PERP,THBS1,CDK6,SFN,GADD45G,PPM1D,TP53I3,CYCS,CDK4,GORAB,CDKN2A,STEAP3,MDM4 ko04115 |p53 signaling pathway |0.21634673242349 |-1.53087291562155|69 |13 |0.0122295390404516 |1063 |7161 |CYCS,TP53I3,CDK4,GADD45G,PPM1D,MDM4,GORAB,STEAP3,CDKN2A,PERP,SFN,THBS1,CDK6 hsa04925 |Aldosterone synthesis and secretion |0.228368491847868 |-1.47679476234578|82 |15 |0.0141110065851364 |1063 |7161 |CACNA1G,DAGLA,CREB3L2,ADCY4,PLCB1,PRKCE,SCARB1,ATF4,PRKACA,ATF2,PRKD3,CREB1,ATF6B,CALML3,ITPR3 ko04925 |Aldosterone synthesis and secretion |0.228368491847868 |-1.47679476234578|82 |15 |0.0141110065851364 |1063 |7161 |ATF4,SCARB1,PRKCE,CREB1,PRKD3,ATF2,PRKACA,CACNA1G,DAGLA,ADCY4,PLCB1,CREB3L2,CALML3,ITPR3,ATF6B ko04210 |Apoptosis |0.229115472514264 |-1.47352915573041|138 |24 |0.0225776105362183 |1063 |7161 |TUBA4A,JUN,BIRC5,ACTG1,ITPR3,PARP3,NFKBIA,TUBA1C,CYCS,RELA,BCL2L1,MAP3K5,LMNB1,CTSZ,MAPK9,LMNA,GZMB,GADD45G,PIK3R1,CASP10,CTSB,ATF4,CFLAR,RIPK1 hsa04210 |Apoptosis |0.229115472514264 |-1.47352915573041|138 |24 |0.0225776105362183 |1063 |7161 |LMNA,GZMB,BCL2L1,MAP3K5,CTSZ,LMNB1,MAPK9,CTSB,RIPK1,ATF4,CFLAR,PIK3R1,GADD45G,CASP10,ITPR3,ACTG1,NFKBIA,PARP3,JUN,TUBA4A,BIRC5,RELA,TUBA1C,CYCS hsa05131 |Shigellosis |0.233677702488949 |-1.45381245281957|64 |12 |0.0112888052681091 |1063 |7161 |ATG5,ACTG1,NFKBIA,PFN4,NFKBIB,MAPK9,ELMO2,RELA,SRC,ROCK2,MAPK14,WASF2 hsa04066 |HIF-1 signaling pathway |0.234881806727182 |-1.4486728414569 |101 |18 |0.0169332079021637 |1063 |7161 |INSR,LTBR,TFRC,EIF4E2,HMOX1,EIF4E,IGF1R,TF,PIK3R1,LDHA,ERBB2,RPS6,VEGFA,MKNK2,EGLN3,RELA,PFKL,ENO1 ko04145 |Phagosome |0.244727819646266 |-1.40760862620824|152 |26 |0.0244590780809031 |1063 |7161 |ATP6V1F,TUBB3,TFRC,ATP6V1G1,TUBB2A,ATP6V0D1,HLA-E,RILP,ATP6V1E2,COMP,SEC61B,TUBA4A,ITGB2,ACTG1,ATP6V1B2,THBS1,CALR,THBS2,C3,TUBA1C,TCIRG1,CYBA,RAB5B,SCARB1,ITGB5,ATP6V0C hsa04145 |Phagosome |0.244727819646266 |-1.40760862620824|152 |26 |0.0244590780809031 |1063 |7161 |TCIRG1,THBS2,C3,TUBA1C,CYBA,RAB5B,ATP6V0C,ITGB5,SCARB1,TUBA4A,ITGB2,ATP6V1B2,THBS1,CALR,ACTG1,ATP6V0D1,HLA-E,COMP,RILP,ATP6V1E2,SEC61B,TFRC,ATP6V1F,TUBB3,TUBB2A,ATP6V1G1 hsa04370 |VEGF signaling pathway |0.252882877410734 |-1.37482883257761|59 |11 |0.0103480714957667 |1063 |7161 |PIK3R1,SPHK2,MAPKAPK3,SRC,MAPK14,MAPKAPK2,SHC2,VEGFA,NFATC2,SPHK1,HSPB1 ko04370 |VEGF signaling pathway |0.252882877410734 |-1.37482883257761|59 |11 |0.0103480714957667 |1063 |7161 |VEGFA,NFATC2,SHC2,HSPB1,SPHK1,MAPKAPK3,MAPK14,MAPKAPK2,SRC,PIK3R1,SPHK2 ko04350 |TGF-beta signaling pathway |0.25840953231831 |-1.35320961797736|84 |15 |0.0141110065851364 |1063 |7161 |INHBC,PPP2CA,RBL1,GDF7,SMAD7,BAMBI,ID1,THBS1,SMAD5,TGIF1,TGFBR2,SMAD6,SP1,BMP6,INHBE hsa04350 |TGF-beta signaling pathway |0.25840953231831 |-1.35320961797736|84 |15 |0.0141110065851364 |1063 |7161 |THBS1,SMAD5,TGFBR2,TGIF1,SP1,SMAD6,INHBE,BMP6,INHBC,PPP2CA,RBL1,GDF7,SMAD7,BAMBI,ID1 ko04390 |Hippo signaling pathway |0.267292681711996 |-1.31941103476801|154 |26 |0.0244590780809031 |1063 |7161 |NKD1,BIRC5,ITGB2,FZD5,WNT11,TCF7L2,YWHAG,TEAD4,CCN2,ACTG1,SMAD7,AXIN2,GSK3B,CSNK1D,PARD6B,GDF7,DLG1,CTNNB1,PPP2CA,BMP6,LLGL2,TEAD3,LATS1,TGFBR2,ID1,AJUBA hsa04390 |Hippo signaling pathway |0.267292681711996 |-1.31941103476801|154 |26 |0.0244590780809031 |1063 |7161 |CCN2,ACTG1,TEAD4,YWHAG,TCF7L2,WNT11,FZD5,BIRC5,ITGB2,NKD1,PPP2CA,CTNNB1,DLG1,GDF7,GSK3B,CSNK1D,PARD6B,AXIN2,SMAD7,TGFBR2,LATS1,LLGL2,TEAD3,BMP6,AJUBA,ID1 hsa04151 |PI3K-Akt signaling pathway |0.268908088138633 |-1.31338563754817|341 |55 |0.0517403574788335 |1063 |7161 |RPS6,VEGFA,YWHAG,PDGFB,THBS1,GNB1,G6PC3,CREB3L2,THBS2,CDK4,F2R,RELA,CREB1,ATF2,LAMA5,ITGB5,ITGA1,PCK2,FGFR3,EIF4E2,CDK6,HSP90AB1,INSR,CSF3R,IL7,FGF17,DDIT4,GNGT2,NGFR,IGF1R,FN1,PGF,ATF4,GRB2,RXRA,RBL2,EFNA2,MYB,PIK3AP1,GSK3B,PKN1,PPP2CA,BCL2L1,PKN2,EPHA2,SOS1,ATF6B,SGK2,ITGB4,PIK3R1,RELN,COMP,GNB5,EIF4E,ITGA6 ko04151 |PI3K-Akt signaling pathway |0.268908088138633 |-1.31338563754817|341 |55 |0.0517403574788335 |1063 |7161 |RXRA,GRB2,MYB,PIK3AP1,RBL2,EFNA2,GSK3B,PPP2CA,PKN1,SOS1,ATF6B,BCL2L1,PKN2,EPHA2,SGK2,RELN,ITGB4,PIK3R1,GNB5,EIF4E,ITGA6,COMP,RPS6,VEGFA,GNB1,YWHAG,PDGFB,THBS1,CDK4,F2R,CREB3L2,G6PC3,THBS2,LAMA5,ITGB5,RELA,CREB1,ATF2,FGFR3,EIF4E2,ITGA1,PCK2,FGF17,CSF3R,INSR,IL7,CDK6,HSP90AB1,NGFR,DDIT4,GNGT2,ATF4,FN1,IGF1R,PGF ko05210 |Colorectal cancer |0.271371614813796 |-1.30426612506215|60 |11 |0.0103480714957667 |1063 |7161 |TGFBR2,TCF7L2,JUN,MAPK9,BIRC5,RALGDS,GSK3B,PIK3R1,CTNNB1,CYCS,AXIN2 hsa05210 |Colorectal cancer |0.271371614813796 |-1.30426612506215|60 |11 |0.0103480714957667 |1063 |7161 |RALGDS,AXIN2,CYCS,PIK3R1,CTNNB1,GSK3B,TCF7L2,TGFBR2,BIRC5,MAPK9,JUN