TermID |Term |Enrichment |logP |Genes in Term|Target Genes in Term|Fraction of Targets in Term|Total Target Genes|Total Genes|Gene Symbols :-----------------------|:----------------------------------------------------------------|:------------------|:----------------|:------------|:-------------------|:--------------------------|:-----------------|:----------|:--------------------------------------------------------------------------------------------------------------------------------------- hif1_tfpathway |HIF-1-alpha transcription factor network |0.00166101789964877|-6.40032467197993|65 |22 |0.0541871921182266 |406 |2226 |ITGB2,FURIN,VEGFA,CREB1,NDRG1,JUN,IGFBP1,CP,HMOX1,HNF4A,TF,PFKL,SP1,EGLN3,ENG,ABCG2,ENO1,LDHA,BHLHE40,CITED2,TFRC,NPM1 pdgfrbpathway |PDGFR-beta signaling pathway |0.00204845193883852|-6.19067092288864|54 |19 |0.0467980295566502 |406 |2226 |SRC,GRB7,NCK2,DOK1,PRKCD,STAT1,PIK3R1,ACP1,PTPN1,VAV2,STAT5B,BCAR1,HCK,STAT5A,PDGFB,SOS1,GRB2,SPHK1,DNM2 hnf3bpathway |FOXA2 and FOXA3 transcription factor networks |0.00312246530438418|-5.76913242751253|44 |16 |0.0394088669950739 |406 |2226 |IGFBP1,BDH1,CEBPA,CEBPB,CREB1,PKLR,CEBPD,FOXA1,TFRC,ACADM,FOXA3,HNF1A,TAT,ACADVL,SP1,HNF4A er_nongenomic_pathway |Plasma membrane estrogen receptor signaling |0.00361162835276136|-5.62359654109068|26 |11 |0.0270935960591133 |406 |2226 |ROCK2,GNA13,GRB2,PIK3R1,SOS1,MMP9,IGF1R,SRC,BCAR1,GNB1,PLCB1 myc_activpathway |Validated targets of C-MYC transcriptional activation |0.00745643745916916|-4.89867753122112|81 |24 |0.0591133004926108 |406 |2226 |NME1-NME2,NME2,EIF4E,HMGA1,E2F3,CDK4,NME1,SUPT3H,TFRC,PTMA,NPM1,SERPINI1,PIM1,BIRC5,NBN,DDX18,MMP9,LDHA,ENO1,NCL,HSPD1,RUVBL1,HSPA4,ODC1 pi3kplctrkpathway |Trk receptor signaling mediated by PI3K and PLC-gamma |0.00766137486147719|-4.87156382550276|32 |12 |0.0295566502463054 |406 |2226 |PRKCD,EPB41L1,SRC,CREB1,STAT5A,GRB2,SOS1,PIK3R1,SFN,YWHAG,GSK3B,EGR1 tcptp_pathway |Signaling events mediated by TCPTP |0.00803606500526387|-4.82381574280584|36 |13 |0.0320197044334975 |406 |2226 |SOS1,PIK3R1,INSR,GRB2,STAT5A,STAT6,SRC,STAT1,VEGFA,STAT5B,PTPN1,KPNB1,ITGA1 nfat_3pathway |Role of Calcineurin-dependent NFAT signaling in lymphocytes |0.0154508616515751 |-4.17009050686501|51 |16 |0.0394088669950739 |406 |2226 |SFN,PRKCE,NFATC3,GSK3B,KPNB1,YWHAG,XPO1,CHP1,PIM1,PRKACA,MAPK14,PRKCD,PRKCH,MAPK9,NFATC2,MEF2D cdc42_pathway |CDC42 signaling events |0.0210687345074324 |-3.85996511431614|70 |20 |0.0492610837438424 |406 |2226 |LIMK2,MAPK9,VAV2,SRC,MAPK14,CTNNB1,ATF2,PIK3R1,PAK4,GSK3B,DLG1,ACTR3,BCAR1,MAP2K7,ARHGDIA,DIAPH3,JUN,PRKCE,RASGRF1,PLD1 rb_1pathway |Regulation of retinoblastoma protein |0.0370470775645994 |-3.29556580849955|56 |16 |0.0394088669950739 |406 |2226 |AATF,BRD2,MAPK9,PPARG,MAPK14,ATF2,SUV39H1,CEBPD,CEBPB,CBX4,CEBPA,PPP2CA,CTBP1,RUNX2,JUN,TBP il2_1pathway |IL2-mediated signaling events |0.0394734986611905 |-3.23212575221244|52 |15 |0.0369458128078818 |406 |2226 |PTK2B,STAT5A,STAT1,MAPK14,SOCS1,CISH,JUN,GRB2,PRKCE,PIK3R1,SOS1,MAPKAPK2,MAPK9,STAT5B,STAM2 faspathway |FAS (CD95) signaling pathway |0.0409520745794669 |-3.19535280868506|35 |11 |0.0270935960591133 |406 |2226 |MAP2K7,MAPK14,SRC,CFLAR,RIPK1,PIK3R1,RFC1,CASP10,SMPD1,MAPK9,CLTC erbb2erbb3pathway |ErbB2/ErbB3 signaling events |0.0409520745794669 |-3.19535280868506|35 |11 |0.0270935960591133 |406 |2226 |MAPK9,ERBB3,JUN,RNF41,GRB2,ERBB2,SOS1,PIK3R1,NFATC4,PRKACA,SRC ar_pathway |Coregulation of Androgen receptor activity |0.0431879728029994 |-3.14219322983257|57 |16 |0.0394088669950739 |406 |2226 |VAV3,NRIP1,GSN,CDK6,PA2G4,CARM1,PTK2B,KDM4C,CTDSP1,XRCC5,FKBP4,TGIF1,MED1,UBE2I,CTNNB1,NCOA4 ar_tf_pathway |Regulation of Androgen receptor activity |0.057609741122722 |-2.85406360886499|50 |14 |0.0344827586206897 |406 |2226 |CARM1,SRC,MAPK14,CEBPA,SMARCE1,PKN1,KAT7,SPDEF,JUN,GSK3B,APPBP2,REL,EGR1,TRIM24 ret_pathway |Signaling events regulated by Ret tyrosine kinase |0.0707021828898629 |-2.64927883116922|38 |11 |0.0270935960591133 |406 |2226 |GRB2,DOK4,SOS1,PIK3R1,JUN,DOK1,SRC,CREB1,GRB7,BCAR1,PRKACA il6_7pathway |IL6-mediated signaling events |0.0772666018275902 |-2.5604934759047 |43 |12 |0.0295566502463054 |406 |2226 |JUN,GRB2,IRF1,PIK3R1,SOS1,HCK,STAT1,PRKCD,MAPK14,CEBPB,CEBPD,LBP rac1_reg_pathway |Regulation of RAC1 activity |0.0830709632582614 |-2.48806005745671|39 |11 |0.0270935960591133 |406 |2226 |NME1,RALBP1,DOCK6,VAV3,DEF6,VAV2,NGEF,ARHGDIA,PREX1,SOS1,RASGRF1 arf6_traffickingpathway |Arf6 trafficking events |0.0895344043274345 |-2.41313232167322|44 |12 |0.0295566502463054 |406 |2226 |PLD1,ARF6,JUP,CTNNB1,CLTC,SDC1,NME1,EXOC2,ITGA1,ITGA6,BIN1,DNM2 hedgehog_glipathway |Hedgehog signaling events mediated by Gli proteins |0.0895344043274345 |-2.41313232167322|44 |12 |0.0295566502463054 |406 |2226 |CSNK1D,PRKACA,MTSS1,SPOP,PRKCD,XPO1,LGALS3,GSK3B,HDAC2,SHH,GNB1,CSNK1G2 rac1_pathway |RAC1 signaling pathway |0.0996882168063215 |-2.30570779549519|54 |14 |0.0344827586206897 |406 |2226 |MAPK9,CYBA,ARHGAP5,ACTR3,WASF2,ATF2,CTNNB1,JUN,MAP2K7,ARHGDIA,NCKAP1,BCAR1,MAPK14,STAT5A erbb1_downstream_pathway|ErbB1 downstream signaling |0.101741224308204 |-2.28532270596419|102 |24 |0.0591133004926108 |406 |2226 |SRC,PRKCD,STAT1,PIK3R1,ATF2,MAPKAP1,WASF2,EGR1,VAV2,MAPK9,CREB1,RALGDS,DIAPH3,NCKAP1,SOS1,PPP2CA,GRB2,PLD1,SFN,JUN,ACTR3,YWHAG,KSR1,RPS6 txa2pathway |Thromboxane A2 receptor signaling |0.102937906233236 |-2.2736293246454 |45 |12 |0.0295566502463054 |406 |2226 |HCK,PRKACA,GNB5,TGM2,PRKCD,SRC,MAPK14,PRKCE,ARHGEF1,PRKCH,GRK3,GNB1 rhoa_reg_pathway |Regulation of RhoA activity |0.117473097939502 |-2.14154592531819|46 |12 |0.0295566502463054 |406 |2226 |SRGAP1,ARHGDIA,FARP1,NGEF,VAV2,ARHGEF1,DEF6,MCF2L,ARHGEF3,VAV3,ARHGAP5,ARAP1 lysophospholipid_pathway|LPA receptor mediated events |0.119365065066722 |-2.12556870821656|65 |16 |0.0394088669950739 |406 |2226 |ARHGEF1,RELA,PIK3R1,GNA13,GNAI3,NFKBIA,SRC,PRKCD,MMP9,GNB1,GSK3B,PRKCE,ADCY4,JUN,BCAR1,PTK2B myc_represspathway |Validated targets of C-MYC transcriptional repression |0.12970982580055 |-2.04245543262213|61 |15 |0.0369458128078818 |406 |2226 |CEBPD,ITGB4,ITGA6,NFYC,SP1,FTH1,DNMT3A,TBP,CFLAR,NDRG1,RBL1,ERBB2,CEBPA,MXD4,CREB1 fgf_pathway |FGF signaling pathway |0.133123860846685 |-2.01647529957526|47 |12 |0.0295566502463054 |406 |2226 |MMP9,PTK2B,SRC,STAT1,JUN,RUNX2,SOS1,PIK3R1,GRB2,PAK4,STAT5B,SPRY2 smad2_3nuclearpathway |Regulation of nuclear SMAD2/3 signaling |0.136639132467551 |-1.99041189799928|76 |18 |0.0443349753694581 |406 |2226 |SMAD7,DLX1,MED15,HNF4A,HDAC2,SP1,SKI,ATF2,TGIF1,CDK4,RBL1,CTBP1,ITGB5,RUNX2,JUN,CEBPB,CREB1,DCP1A cxcr4_pathway |CXCR4-mediated signaling events |0.136639132467551 |-1.99041189799928|76 |18 |0.0443349753694581 |406 |2226 |RALB,BCAR1,PTK2B,VPS4A,HCK,STAT5A,PLCB1,GNB1,ITGA6,GNA13,PIK3R1,STAT1,SRC,MMP9,STAT5B,ITGA1,ITCH,MAPKAP1 hnf3apathway |FOXA1 transcription factor network |0.145065621717723 |-1.93056907536707|43 |11 |0.0270935960591133 |406 |2226 |SHH,NRIP1,SP1,ATP5PF,FOXA1,JUN,PISD,FOXA3,APOB,CEBPB,NCOA3 nfat_tfpathway |Calcineurin-regulated NFAT-dependent transcription in lymphocytes|0.149862180591394 |-1.89803920329508|48 |12 |0.0295566502463054 |406 |2226 |PTPRK,E2F1,PPARG,EGR4,JUN,CDK4,ITCH,IRF4,PTPN1,NFATC2,NFATC3,EGR1 fak_pathway |Signaling events mediated by focal adhesion kinase |0.170813542841965 |-1.76718271012718|54 |13 |0.0320197044334975 |406 |2226 |BCAR1,GRB7,SRC,ARHGAP26,PIK3R1,ITGB5,SOS1,MMP14,GRB2,JUN,ROCK2,SH3GL1,MAPK9 p53regulationpathway |p53 pathway |0.173256042702504 |-1.75298476300663|59 |14 |0.0344827586206897 |406 |2226 |PRMT5,PPP2CA,MAPK14,PRKCD,USP7,RPL23,CSNK1D,SMYD2,CSE1L,CSNK1G2,MAPK9,PPM1D,MDM4,GSK3B ptp1bpathway |Signaling events mediated by PTP1B |0.186432837630024 |-1.67968422470328|50 |12 |0.0295566502463054 |406 |2226 |PTPN1,SPRY2,STAT5B,TXN,INSR,GRB2,PIK3R1,DOK1,BCAR1,SRC,STAT5A,HCK avb3_integrin_pathway |Integrins in angiogenesis |0.203849460312507 |-1.59037349719398|46 |11 |0.0270935960591133 |406 |2226 |IGF1R,SRC,BCAR1,PTK2B,TGFBR2,PIK3R1,F11R,VAV3,FN1,SDC1,VEGFA hdac_classi_pathway |Signaling events mediated by HDAC Class I |0.209299362364633 |-1.56398969604876|66 |15 |0.0369458128078818 |406 |2226 |PRMT5,ZFPM1,NFKBIA,XPO1,HDAC10,PPARG,PRKACA,UBE2I,GATAD2A,SMAD7,NCOR2,MXD1,HDAC2,RELA,SIRT5 reg_gr_pathway |Glucocorticoid receptor regulatory network |0.225353481790687 |-1.49008507937381|82 |18 |0.0443349753694581 |406 |2226 |CREB1,STAT5A,FKBP5,SFN,JUN,TBP,GSK3B,STAT1,MAPK14,PRKACA,IRF1,RELA,HDAC2,FKBP4,EGR1,STAT5B,MAPK9,PCK2