TermID |Term |Enrichment |logP |Genes in Term|Target Genes in Term|Fraction of Targets in Term|Total Target Genes|Total Genes|Gene Symbols :------------|:------------------------------------------------------------------------------------------------------------------|:-------------------|:----------------|:------------|:-------------------|:--------------------------|:-----------------|:----------|:----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- R-HSA-1430728|Metabolism |7.3467388528584e-08 |-16.4264242226774|2158 |396 |0.262078093977498 |1511 |10287 |SLC6A12,UBA52,RPL31,MTHFD1L,ATP5MC2,RPL9,ABCG2,ACO2,SPTSSB,PARP16,AGT,B3GNT2,RELN,HADHB,PTGR2,SLC25A13,G6PC3,NDUFS5,GSS,ADI1,RPS14,NAGLU,ALDH3B1,GRHPR,SDC1,NUDT3,ELOVL6,DEGS2,ST3GAL1,GALK1,LSR,CRYL1,CHKA,MED15,CERS2,SLC6A11,N6AMT1,ENOPH1,BDH1,CHP1,SLC44A1,TYMP,RPS7,ECI1,PLCB1,PAPSS2,INPP4A,CYP27A1,SARDH,PANK3,PSMB10,APOC3,FAM120B,INPP1,MAT1A,SLC25A19,QPRT,NDUFV2,MOCS3,AMD1,SCAP,NDUFB9,PITPNM1,B3GNT3,CA4,MPC1,PSMC5,SLC7A5,MMUT,DCTPP1,MED23,ACSL6,PTDSS2,PDSS2,NUDT9,RPL37A,SUCLA2,SLC35D1,ATP5F1B,PKLR,IP6K3,ACSL5,PLCD3,KPNB1,CSNK2B,ST3GAL2,NDC1,AHCY,HSD11B2,CYCS,IARS,GLUL,ACY1,FURIN,SUCLG2,MAPKAPK2,PANK2,NUP210,BPHL,PECR,ATP5ME,MED11,SLC22A1,ESRRA,MTHFS,PITPNM2,LDHAL6B,SLC5A2,MARC1,SLC50A1,ATIC,SLC25A12,RPS15A,ENTPD5,DHCR7,LCAT,XYLB,FDXR,MTF1,ENTPD6,ADRA2C,NME1,DSE,ALDH1L1,SLC16A3,TRIB3,ABCA1,LMF1,NDUFAF6,RFK,RXRA,KHK,HAAO,SLC25A37,CARM1,APOE,PCYT2,PLD1,RPS26,ATP5F1D,CPNE1,NDUFA7,SMPD1,GNB5,MED1,ETFA,AMDHD1,NCOA3,ADCY4,MAN2C1,GCLC,MRI1,AACS,MIR6741,TALDO1,PSMB11,KYAT1,FITM2,ADK,ENPP7,HS6ST1,TM7SF2,DAO,SPTSSA,RPL27,NDST1,COQ9,OSBPL2,NDUFB2,GDE1,APRT,ARF3,LIPT1,ACBD6,RPL23,XYLT2,INPP5D,ITPKA,SMOX,CIAPIN1,AMT,PCSK6,CHST3,LPIN3,GMPR2,MIR6787,GOT2,RPS21,ACADM,GNB1,UBIAD1,MAT2A,PGM2,PSMD1,B3GNT7,RPS16,ATP5PF,MLX,AGPAT1,CPNE7,COQ10B,PRKAR1A,TYMS,SLC25A10,FASN,B4GALT4,SLC19A1,PGD,GCHFR,SLC25A15,PPARGC1A,UPP1,ANGPTL8,NDUFS7,MOGAT2,AIMP2,SPHK2,SPR,CLTC,IDH1,HMOX1,PMVK,CA5A,NUP54,AGPAT3,GDPD3,PSMD7,MBTPS1,CERS4,MED9,NT5C2,RPL29,GUK1,HSD3B7,ODC1,ABHD4,SLC27A5,SERINC3,NME2,PIK3R1,DHODH,THTPA,PLTP,BCKDK,COQ2,SLC25A21,LDHA,CIAO1,GPCPD1,AAAS,COX15,ALOX5AP,NAXD,PYGB,MTMR2,BCAT2,GPX4,TXN,CEMIP,PLEKHA8,COX5B,FDX2,ACADVL,ITPA,CYP2W1,PISD,PPARG,COX4I1,FADS1,SP1,MTHFD2,IDUA,PSMA6,PPT2,TEAD3,MCCC2,GCGR,NT5C,PPP1R3C,APOB,BRIP1,HACD3,AGMAT,ESYT1,HS3ST3A1,NDUFAF5,SUMF1,UGP2,PSME3,DGAT1,GPD2,CHST13,PAPSS1,GPD1L,RPS28,ATP5MC3,NMRAL1,LRP10,OSBPL9,NADK,NDUFS6,PSMB3,CRLS1,SPHK1,RAE1,GPT2,ITPR3,PCK2,NFS1,NAMPT,PSMD9,POR,SCLY,GNGT2,UQCRC2,HAL,APOA2,PHKB,SCO1,PSMD14,STARD10,CCN2,PDK2,B4GALT5,MTMR4,TEAD4,HDLBP,SMPD4,FADS2,PRKD3,STARD7,B4GALT3,PNPO,ACBD4,PSMF1,PFKL,PSMD3,ORMDL3,CSNK1G2,ITPKC,DNM2,MVK,OSBPL3,OAT,TAT,SCARB1,RPS27A,SLC44A4,GAA,NUP42,HSP90AB1,NPAS2,ALDH2,GPAT2,CYP3A5,NDUFAB1,UGT2B10,NR1D1,ATP5MC1,PNPLA6,ALDH1B1,PRKAR2A,RPS6,SDC4,HS3ST3B1,BLVRA,B4GALT2,AP2M1,ACOX1,PSMD12,MIR1281,SYNJ2,ACSM2B,RPL18,GLDC,NCOR2,ACSS1,GNPAT,IP6K2,ENO1,CERK,MANBA,CDS2,TST,CSAD,PCBD1,SLC23A2,NFYC,UPP2,ABCC3,CHPF,PPP2CA,MOGAT1,DECR2,MT2A,PRKACA R-HSA-74160 |Gene Expression |3.04543302916665e-05|-10.3992823640123|1821 |324 |0.214427531436135 |1511 |10287 |NCOR2,KRR1,RIOK1,NR0B2,NDRG1,METTL3,DDX42,PSMD12,MIR1281,RPL18,TYW5,LSM2,TBP,PPP2CA,INTS12,SNRPB,SRP68,RUNX2,WWOX,NUP42,CD2BP2,GCFC2,HNRNPD,LTV1,ZNF274,RPS27A,ZNF839,SRRT,RPS6,IPO8,TGFA,MOV10,TGIF1,IGF2BP1,NR1D1,WDR61,SCO1,SKIV2L,GATAD2A,PSMD14,CCN2,TEAD4,HSPB1,SEC61B,SMAD7,THRA,EEF1B2,WDR33,SRPRA,WBP4,JMY,AURKA,CSNK1D,DCP1B,ZNF433,PRMT1,SUV39H1,ZNF500,PSMF1,DCP1A,PSMD3,MAPK14,PRDX5,SNRNP200,ZNF343,PSMB3,GTF2E2,POLR3E,RBL2,RPS28,PSMD9,NBN,JARID2,NOL9,WDR18,PRORP,RAE1,DNMT3A,STEAP3,MAPKAP1,PRPF6,EIF5B,GATA4,ZNF860,L3MBTL1,PSMA6,TEAD3,GTF2A2,CRADD,SF3B6,PPARG,COX4I1,HSPD1,ZNF555,SP1,PSME3,HIST1H2BI,AARS2,TSEN15,ZNF710,BRIP1,LSM5,EARS2,DDIT4,AAAS,LAMTOR5,RPN1,SRSF6,CITED2,GSK3B,ICE2,SRSF10,TXN,COX5B,EIF2B4,APEH,HNRNPUL1,ERBB2,CPSF1,XRN2,WTAP,NUP54,PSMD7,RARA,TSEN2,NR2F6,ZNF77,CCNT1,CRCP,POLR1D,YWHAG,TSN,HNRNPF,RMI2,RPL29,ZNF398,SMYD2,MOV10L1,VEGFA,LAMTOR2,ZNF441,SRP9,CHERP,POLR1C,SLBP,TAF4,KDM5B,AIMP2,CRNKL1,MTO1,MIR1292,MYO1C,GTF3C2,TRMT6,CASC3,SNRPA,PRPF31,TAF8,PUF60,ELL3,HDAC2,DUS2,RPL23,EIF4A3,DDX46,PSMD1,HNRNPH1,RPS16,RPS21,PRMT5,TBL3,RBL1,ZNF584,ZNF700,EDC4,CASP10,TNPO1,MED1,TNRC6A,TFAM,NRBP1,RPL27,RNPS1,ZNF771,METTL1,ZFP69B,LSM4,EXOSC6,UTP18,USP7,PSMB11,NOP14,FARSB,ZNF19,HIST1H2BN,HNF4A,TOP3A,POLR2A,ZNF552,ADAT3,SFN,APOE,ZNF311,RPS26,MDM4,E2F1,IGF2BP2,ARID3A,RXRA,PERP,CARM1,ZNF775,ZKSCAN8,EIF3G,ESRRA,MTF2,MPHOSPH10,ZNF747,CDKN2A,RABGGTA,CITED4,AGO1,PRKCD,EIF3D,RPS15A,EIF2B2,SUPT5H,TFB1M,SNRPC,CYCS,VARS,ZNF337,NFIX,NR2F1,EFTUD2,TXNL4A,HNRNPA3,SNRNP48,RXRB,CSNK2B,NDC1,BANP,NUP210,ZNF720,ZC3H8,TNRC6C,POLR2D,IARS,NUAK1,PHF20,MAPKAPK2,ING5,CARS,ZNF770,GSPT1,ZNF778,ZSCAN25,SRRM2,THUMPD1,MYBL2,PSMB10,DNMT3B,IARS2,SNRPB2,BIRC5,ADAT2,CNOT11,PSMC5,JUN,MED23,ZNF786,ZFP37,RPL37A,TET3,POLR3B,ZNF564,PHF1,N6AMT1,IWS1,NOL11,SNAPC3,RPS7,TOPBP1,EIF4E,DIMT1,ZNF517,TP53I3,DDX1,HUS1,EIF2S2,ZNF709,MED15,WDR4,GTF2H1,FTSJ1,HIST1H4C,NPM1,SENP3,INTS14,MTA3,ELL,XPO1,SET,ZNF697,TRMT10A,GTF2H5,UBA52,RPL31,ZNF23,FARS2,RPL9,UBE2I,RPS14,ZNF624,ZFP90,IGF2BP3,ZNF764,ATF2,INTS2,SKI,PUS7,THOC7,TRMT11,TP53RK R-HSA-2262752|Cellular responses to stress |4.37799699218388e-05|-10.0363341528995|451 |97 |0.0641958967571145 |1511 |10287 |HMGA1,PSMB11,HIST1H2BN,PSMC5,TXN,WDR45B,JUN,ACD,DNAJC7,CEBPB,HIST1H1A,ASF1A,MOV10,GSK3B,EGLN3,PSMB10,GABARAPL2,TNRC6A,HSPA4,RPS27A,LMNB1,PRDX6,AAAS,LAMTOR5,NUP42,HSP90AB1,TXN2,SOD2,CITED2,E2F3,AJUBA,CHMP4A,MAPKAPK2,ANAPC5,CDK6,HSPA14,HIST1H2BI,PSME3,NUP210,UBE2C,PSMD1,HIKESHI,ULK1,TNRC6C,PSMD12,MIR1281,TERF2IP,ATG5,ATG10,ATG4B,SP1,NDC1,PSMA6,CYCS,DYNLL2,MAP2K7,RAE1,CBX4,RB1CC1,CHMP6,PSMD9,NBN,CDK4,FKBP4,LAMTOR2,ST13,UBA52,HIST1H1E,ANAPC11,ATG101,TERF2,AGO1,HIST1H4C,PRDX5,CHMP4B,MAPKAPK3,BAG2,CHMP3,VEGFA,PSMB3,CDKN2A,PSMF1,PSMD3,MAPK14,MDM4,E2F1,MAP3K5,EPAS1,MAP4K4,CYBA,MAPK9,PSMD14,NUP54,RELA,HSPA5,PSMD7,ID1 R-HSA-2559585|Oncogene Induced Senescence |7.12894757695298e-05|-9.54876184635413|32 |14 |0.00926538716082065 |1511 |10287 |CDK6,MDM4,CDK4,CDKN2A,E2F1,ID1,TNRC6C,E2F3,MOV10,UBA52,TNRC6A,RPS27A,SP1,AGO1 R-HSA-917937 |Iron uptake and transport |0.000305186994656022|-8.09458587199133|44 |16 |0.0105890138980807 |1511 |10287 |ATP6V1G1,ABCG2,TFRC,HMOX1,ATP6V0C,CP,ATP6V1B2,SLC22A17,ATP6V1E2,ATP6V0D1,FTH1,ATP6V1F,FTL,STEAP3,TCIRG1,TF R-HSA-5687128|MAPK6/MAPK4 signaling |0.000380410745440547|-7.87425897995134|90 |26 |0.0172071475843812 |1511 |10287 |AGO1,RPS27A,TNRC6A,PSMB10,UBA52,PSMD12,XPO1,PSMD7,PSMB3,HSPB1,PSMA6,PSMD14,NCOA3,PSMD3,ETV4,PSMF1,PSMB11,IGF2BP1,TNRC6C,MOV10,PRKACA,PSMD1,JUN,PSME3,PSMD9,PSMC5 R-HSA-453274 |Mitotic G2-G2/M phases |0.000564367139721347|-7.47980556129405|184 |44 |0.029119788219722 |1511 |10287 |PSMB10,UBA52,MYBL2,RPS27A,CCP110,PCM1,HSP90AB1,CEP63,AKAP9,PSMB3,ALMS1,E2F3,XPO1,PPP1R12B,TUBGCP3,HAUS4,PSMB11,PSMD9,PSMC5,CKAP5,NINL,PSMD12,TUBGCP6,MIR1281,PSMD14,HAUS8,PSMA6,WEE1,TUBA4A,PSMD7,AJUBA,CDC25B,CEP250,PSMD3,PSMF1,PHLDA1,PPP2CA,PSME3,CSNK1D,PSMD1,AURKA,PRKACA,E2F1,YWHAG R-HSA-71291 |Metabolism of amino acids and derivatives |0.000913913593580788|-6.99777452754268|361 |75 |0.0496360026472535 |1511 |10287 |AMT,MCCC2,PSMA6,SMOX,AHCY,GLDC,RPL23,LIPT1,RPL18,PSMD12,RPS16,PSMD1,PSME3,GOT2,RPS21,AGMAT,TST,PCBD1,CSAD,IARS,GLUL,AMD1,GCLC,MAT1A,SLC25A21,AMDHD1,RPS27A,BCKDK,PSMB10,RPL37A,RPL27,RPS6,SLC7A5,PSMC5,DAO,BCAT2,PSMB11,NDUFAB1,KYAT1,MRI1,MIR6741,PSMD7,RPS7,ENOPH1,PSMD14,SLC6A11,GRHPR,TAT,OAT,ODC1,SERINC3,RPS26,PSMF1,RPL29,HAAO,PSMD3,PAPSS2,SLC25A15,PSMB3,SLC25A10,RPL9,RPL31,NMRAL1,RPS28,SLC6A12,UBA52,PAPSS1,RPS15A,HAL,AIMP2,SCLY,PSMD9,RPS14,ADI1,GPT2 R-HSA-450531 |Regulation of mRNA stability by proteins that bind AU-rich elements |0.00109871853872286 |-6.81361074307417|91 |25 |0.0165453342157512 |1511 |10287 |EXOSC6,PSMB11,PSMF1,DCP1A,PSMD3,MAPKAPK2,MAPK14,PSMD9,PSMC5,PSME3,PRKCD,PSMD1,SET,HNRNPD,PSMD12,UBA52,TNPO1,PSMB10,RPS27A,PSMD14,PSMA6,HSPB1,PSMB3,PSMD7,XPO1 R-HSA-351202 |Metabolism of polyamines |0.0012863470003492 |-6.65594886036562|87 |24 |0.0158835208471211 |1511 |10287 |PSMB3,PSMD7,AMD1,SLC25A15,ENOPH1,PSMD14,SMOX,PSMA6,NMRAL1,SLC6A11,PSMD12,PSMB10,SLC6A12,PSMD1,ODC1,PSME3,PSMC5,PSMD9,PSMD3,PSMF1,ADI1,MRI1,AGMAT,PSMB11 R-HSA-69275 |G2/M Transition |0.0015750666874185 |-6.45345766638281|182 |42 |0.0277961614824619 |1511 |10287 |TUBA4A,WEE1,PSMA6,PSMD14,HAUS8,PSMD7,MIR1281,TUBGCP6,PSMD12,PSME3,PPP2CA,YWHAG,PSMD1,PRKACA,AURKA,CSNK1D,CEP250,CDC25B,AJUBA,PHLDA1,PSMF1,PSMD3,AKAP9,HSP90AB1,CEP63,PCM1,PPP1R12B,ALMS1,XPO1,PSMB3,MYBL2,UBA52,PSMB10,CCP110,RPS27A,CKAP5,PSMC5,PSMD9,NINL,PSMB11,HAUS4,TUBGCP3 R-HSA-68867 |Assembly of the pre-replicative complex |0.00165342351914873 |-6.40490728052888|69 |20 |0.0132362673726009 |1511 |10287 |PSMB11,PSMD3,PSMF1,PSME3,PSMC5,PSMD9,E2F1,PSMD1,PSMB10,UBA52,PSMD12,RPS27A,GMNN,CDT1,PSMA6,ORC2,PSMD14,E2F3,PSMD7,PSMB3 R-HSA-68827 |CDT1 association with the CDC6:ORC:origin complex |0.00181251660878888 |-6.3130390078077 |60 |18 |0.0119126406353408 |1511 |10287 |RPS27A,GMNN,PSMB10,UBA52,PSMD12,PSMD7,PSMB3,ORC2,CDT1,PSMA6,PSMD14,PSMF1,PSMD3,PSMB11,PSMD1,PSME3,PSMC5,PSMD9 R-HSA-4641257|Degradation of AXIN |0.00208655333828384 |-6.17224169473972|56 |17 |0.0112508272667108 |1511 |10287 |RPS27A,PSMD12,PSMB10,UBA52,PSMB3,PSMD7,PSMD14,PSMA6,AXIN2,RNF146,PSMD3,PSMF1,PSMB11,PSMD1,PSME3,PSMC5,PSMD9 R-HSA-69229 |Ubiquitin-dependent degradation of Cyclin D1 |0.00239459515156969 |-6.03454110141853|52 |16 |0.0105890138980807 |1511 |10287 |RPS27A,PSMB10,UBA52,PSMD12,PSMD7,PSMB3,PSMA6,PSMD14,PSMF1,PSMD3,PSMB11,PSMD1,CDK4,PSMD9,PSME3,PSMC5 R-HSA-75815 |Ubiquitin-dependent degradation of Cyclin D |0.00239459515156969 |-6.03454110141853|52 |16 |0.0105890138980807 |1511 |10287 |PSMA6,PSMD14,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,RPS27A,PSMD9,PSMC5,PSME3,PSMD1,CDK4,PSMB11,PSMF1,PSMD3 R-HSA-450408 |AUF1 (hnRNP D0) binds and destabilizes mRNA |0.00257421615687348 |-5.96221019630475|57 |17 |0.0112508272667108 |1511 |10287 |PSMD7,HSPB1,PSMB3,PSMA6,PSMD14,RPS27A,PSMB10,UBA52,HNRNPD,PSMD12,PSMD1,PSMC5,PSME3,PSMD9,PSMF1,PSMD3,PSMB11 R-HSA-1234174|Regulation of Hypoxia-inducible Factor (HIF) by oxygen |0.00292647801669442 |-5.83395562106903|77 |21 |0.013898080741231 |1511 |10287 |PSMC5,PSMD9,PSME3,PSMD1,PSMB11,AJUBA,PSMF1,PSMD3,PSMA6,PSMD14,PSMD7,CITED2,VEGFA,PSMB3,MIR1281,PSMB10,EGLN3,UBA52,PSMD12,EPAS1,RPS27A R-HSA-2262749|Cellular response to hypoxia |0.00292647801669442 |-5.83395562106903|77 |21 |0.013898080741231 |1511 |10287 |PSME3,PSMC5,PSMD9,PSMD1,AJUBA,PSMB11,PSMF1,PSMD3,PSMD14,PSMA6,VEGFA,PSMB3,PSMD7,CITED2,PSMD12,MIR1281,UBA52,PSMB10,EGLN3,EPAS1,RPS27A R-HSA-5362768|Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |0.0031531749243027 |-5.75934542127028|58 |17 |0.0112508272667108 |1511 |10287 |PSMB11,PSMD3,PSMF1,PSME3,PSMD9,PSMC5,PSMD1,SHH,PSMB10,UBA52,PSMD12,ERLEC1,RPS27A,PSMA6,PSMD14,PSMD7,PSMB3 R-HSA-71387 |Metabolism of carbohydrates |0.00320454073375301 |-5.7431864956784 |296 |61 |0.0403706154864328 |1511 |10287 |ST3GAL2,XYLB,NDC1,DSE,PKLR,SDC1,CRYL1,ST3GAL1,PHKB,GALK1,CHST3,MANBA,NUP54,PPP1R3C,XYLT2,ENO1,B4GALT5,CHP1,IDUA,KHK,PFKL,HS3ST3A1,CHPF,UGP2,B4GALT3,PAPSS2,GOT2,PRKACA,CHST13,B3GNT7,NUP210,PPP2CA,PGM2,RPS27A,SLC25A10,PAPSS1,UBA52,PGD,B3GNT2,SLC25A13,MAN2C1,GAA,AAAS,B4GALT4,NUP42,SLC50A1,HS6ST1,G6PC3,TALDO1,SLC5A2,RAE1,PCK2,B3GNT3,PYGB,HS3ST3B1,SDC4,B4GALT2,NAGLU,CEMIP,NDST1,SLC25A12 R-HSA-1169091|Activation of NF-kappaB in B cells |0.00338072475326695 |-5.68966516842928|68 |19 |0.0125744540039709 |1511 |10287 |PSMD1,PSME3,PSMC5,PSMD9,PSMF1,PSMD3,PSMB11,REL,PSMD7,NFKBIB,NFKBIA,PSMB3,RELA,PSMA6,PSMD14,RPS27A,UBA52,PSMB10,PSMD12 R-HSA-8864260|Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |0.00351882852479847 |-5.64962715021914|40 |13 |0.0086035737921906 |1511 |10287 |APOE,UBE2I,NPM1,CITED2,TGFA,CITED4,KDM5B,VEGFA,MYBL2,MIR1281,WWOX,ERBB2,HSPD1 R-HSA-169911 |Regulation of Apoptosis |0.00365821904667517 |-5.61077884926578|54 |16 |0.0105890138980807 |1511 |10287 |RPS27A,UBA52,PSMB10,PSMD12,PSMD7,PSMB3,OMA1,PSMA6,PSMD14,PSMF1,PSMD3,PSMB11,PSMD1,PSMD9,PSMC5,PSME3 R-HSA-2151201|Transcriptional activation of mitochondrial biogenesis |0.00392058123063185 |-5.54151536305077|45 |14 |0.00926538716082065 |1511 |10287 |CYCS,ESRRA,POLG2,TFB1M,MEF2D,CREB1,ATF2,ATP5F1B,PPARGC1A,MED1,NR1D1,TFAM,RXRA,CARM1 R-HSA-535734 |Fatty acid, triacylglycerol, and ketone body metabolism |0.00406222254192682 |-5.50602503103051|253 |53 |0.0350761085373925 |1511 |10287 |ACADM,MED9,HACD3,NFYC,CARM1,RXRA,MOGAT1,AGPAT1,GPD2,DGAT1,DECR2,PPARG,MIR1281,APOA2,ACOX1,ELOVL6,SP1,MED15,ACBD6,MTF1,FADS1,ACSL5,TEAD4,ABCA1,CCN2,BDH1,TRIB3,NCOR2,ECI1,TEAD3,LPIN3,PPT2,AGPAT3,NR1D1,NDUFAB1,AACS,PPARGC1A,GPAT2,MOGAT2,ACADVL,MED23,ACSL6,MMUT,MED1,FAM120B,GPD1L,MED11,ESRRA,AGT,NCOA3,FASN,NPAS2,HADHB R-HSA-556833 |Metabolism of lipids and lipoproteins |0.00420797521769198 |-5.47077369289582|813 |146 |0.0966247518199868 |1511 |10287 |PITPNM2,DHCR7,MED11,GPD1L,PECR,CRLS1,SPHK1,OSBPL9,ESRRA,RXRA,ORMDL3,CARM1,STARD7,ACBD4,MVK,OSBPL3,CPNE1,APOE,CSNK1G2,PLD1,PCYT2,FDXR,MTF1,APOA2,LCAT,SMPD4,FADS2,PRKD3,LMF1,STARD10,TRIB3,CCN2,TEAD4,HDLBP,MTMR4,ABCA1,PNPLA6,FITM2,ENPP7,GPAT2,AACS,NDUFAB1,NR1D1,OSBPL2,GDE1,COQ9,TM7SF2,SPTSSA,SLC44A4,SMPD1,MED1,SCARB1,NPAS2,NCOA3,NFYC,ABCC3,ACADM,PRKACA,DECR2,AGPAT1,MOGAT1,ARF3,ACBD6,AP2M1,ACOX1,MIR1281,SYNJ2,LPIN3,PCSK6,CDS2,NCOR2,INPP5D,GNPAT,CERK,MOGAT2,PPARGC1A,ANGPTL8,ALDH3B1,CPNE7,RELN,HADHB,PTGR2,FASN,SPTSSB,AGT,INPP4A,MBTPS1,CERS4,MED9,SLC27A5,ABHD4,PIK3R1,SARDH,HSD3B7,CYP27A1,CHKA,MED15,CERS2,SPHK2,ELOVL6,LSR,DEGS2,CLTC,SLC44A1,GDPD3,AGPAT3,ECI1,IDH1,BDH1,PMVK,GPX4,SCAP,PITPNM1,MTMR2,PDSS2,FDX2,MMUT,PLEKHA8,ACSL6,MED23,ACADVL,PTDSS2,COQ2,PLTP,APOC3,FAM120B,ALOX5AP,GPCPD1,MAPKAPK2,ESYT1,SUMF1,APOB,HACD3,FURIN,DGAT1,GPD2,ACSL5,FADS1,KPNB1,CSNK2B,SP1,PISD,PPARG,PPT2,TEAD3,HSD11B2 R-HSA-5689603|UCH proteinases |0.00432343976303383 |-5.44370395211515|105 |26 |0.0172071475843812 |1511 |10287 |PSMB11,PSMD3,PSMF1,INO80D,PSMC5,PSMD9,PSME3,ADRM1,PSMD1,RUVBL1,TGFBR2,ASXL1,PSMD12,SMAD7,PSMB10,UBA52,RPS27A,USP15,FOXK1,PSMD14,PSMA6,PSMB3,FOXK2,MBD6,TFPT,PSMD7 R-HSA-5663205|Infectious disease |0.00441196553588613 |-5.42343498907059|388 |76 |0.0502978160158835 |1511 |10287 |RAE1,RPS15A,RPS14,PSMD9,CHMP6,TAF4,VPS4A,RPL31,RPL9,GTF2E2,UBA52,GTF2H5,RPS28,ELL,PSMB3,XPO1,CALR,NPM1,CHMP4B,CHMP3,GRB2,STAM2,PSMD3,PDCD6IP,PSMF1,HCK,RPL29,STX1B,KPNA4,CCNT1,AP1S3,GTF2H1,RPS26,XRCC5,CLTC,NUP54,POLR2A,RPS7,PSMD7,PSMD14,SRC,HMGA1,PSMB11,SH3GL1,RPL37A,PSMC5,RPS6,RPL27,RPS27A,PSMB10,CD28,CTNNB1,AAAS,HSP90AB1,PPIA,NUP42,CHMP4A,POLR2D,RPS21,FURIN,PSMD1,RPS16,NUP210,PSME3,KPNB1,KPNA5,TBP,RPL23,NDC1,PSMD12,AP2M1,RPL18,GTF2A2,MAP2K7,SUPT5H,PSMA6 R-HSA-5387390|Hh mutants abrogate ligand secretion |0.00463586467722647 |-5.37393254348491|60 |17 |0.0112508272667108 |1511 |10287 |SHH,PSMD1,PSMC5,PSME3,PSMD9,PSMF1,PSMD3,PSMB11,PSMD7,PSMB3,PSMA6,PSMD14,ERLEC1,RPS27A,PSMB10,UBA52,PSMD12 R-HSA-211733 |Regulation of activated PAK-2p34 by proteasome mediated degradation |0.00520217298484001 |-5.25867885898299|51 |15 |0.0099272005294507 |1511 |10287 |PSMF1,RPS27A,PSMD3,PSMB11,PSMB10,UBA52,PSMD12,PSMD7,PSMD1,PSMB3,PSMA6,PSMC5,PSMD9,PSME3,PSMD14 R-HSA-174113 |SCF-beta-TrCP mediated degradation of Emi1 |0.00542386323582296 |-5.21694694329635|56 |16 |0.0105890138980807 |1511 |10287 |PSMD7,PSMB3,PSMA6,PSMD14,RPS27A,UBA52,PSMB10,PSMD12,PSMD1,FBXO5,PSMD9,PSME3,PSMC5,PSMF1,PSMD3,PSMB11 R-HSA-8854050|FBXL7 down-regulates AURKA during mitotic entry and in early mitosis |0.00542386323582296 |-5.21694694329635|56 |16 |0.0105890138980807 |1511 |10287 |PSMD1,AURKA,PSMD9,PSME3,PSMC5,PSMF1,PSMD3,PSMB11,PSMD7,PSMB3,PSMA6,PSMD14,RPS27A,PSMB10,UBA52,PSMD12 R-HSA-69541 |Stabilization of p53 |0.00542386323582296 |-5.21694694329635|56 |16 |0.0105890138980807 |1511 |10287 |UBA52,PSMB10,PSMD12,RPS27A,PSMA6,PSMD14,PSMD7,PSMB3,PSMB11,PSMD3,PSMF1,MDM4,PSMC5,PSMD9,PSME3,PSMD1 R-HSA-68874 |M/G1 Transition |0.00549498661328211 |-5.20391912729292|86 |22 |0.014559894109861 |1511 |10287 |PSMD12,PSMB10,UBA52,RPS27A,GMNN,PSMD14,PSMA6,CDT1,ORC2,PSMB3,PRIM2,E2F3,PSMD7,POLE2,PSMB11,PSMD3,PSMF1,PSMC5,PSME3,PSMD9,PSMD1,E2F1 R-HSA-69002 |DNA Replication Pre-Initiation |0.00549498661328211 |-5.20391912729292|86 |22 |0.014559894109861 |1511 |10287 |PSMD14,PSMA6,CDT1,ORC2,PSMB3,E2F3,PRIM2,PSMD7,PSMD12,PSMB10,UBA52,GMNN,RPS27A,PSMC5,PSME3,PSMD9,PSMD1,E2F1,POLE2,PSMB11,PSMD3,PSMF1 R-HSA-5610780|Degradation of GLI1 by the proteasome |0.00556734968932469 |-5.19083615707332|61 |17 |0.0112508272667108 |1511 |10287 |PSMA6,PSMD14,PSMD7,PSMB3,UBA52,PSMB10,ITCH,PSMD12,RPS27A,PSME3,PSMD9,PSMC5,PRKACA,PSMD1,PSMB11,PSMD3,PSMF1 R-HSA-5610783|Degradation of GLI2 by the proteasome |0.00556734968932469 |-5.19083615707332|61 |17 |0.0112508272667108 |1511 |10287 |PSMD7,PSMB3,PSMA6,PSMD14,RPS27A,UBA52,PSMB10,GSK3B,PSMD12,PSMD1,PRKACA,PSMC5,PSME3,PSMD9,PSMD3,PSMF1,PSMB11 R-HSA-5610785|GLI3 is processed to GLI3R by the proteasome |0.00556734968932469 |-5.19083615707332|61 |17 |0.0112508272667108 |1511 |10287 |PSMB3,PSMD7,PSMD14,PSMA6,RPS27A,PSMD12,UBA52,PSMB10,GSK3B,PRKACA,PSMD1,PSMC5,PSME3,PSMD9,PSMD3,PSMF1,PSMB11 R-HSA-109581 |Apoptosis |0.00560809356601595 |-5.18354444500673|172 |38 |0.0251489080079418 |1511 |10287 |DSP,RIPK1,CFLAR,PSMD3,PSMF1,E2F1,GSN,YWHAG,DNM1L,PSMD1,PSME3,SFN,KPNB1,PSMD12,ACIN1,BCL2L1,PSMD7,DYNLL2,UNC5A,CYCS,PSMA6,GZMB,OMA1,PSMD14,LMNA,PSMB11,HIST1H1A,PRKCD,PSMD9,PSMC5,LMNB1,BMF,HIST1H1E,RPS27A,PSMB10,UBA52,CTNNB1,PSMB3 R-HSA-382556 |ABC-family proteins mediated transport |0.00564608443063797 |-5.17679299519996|107 |26 |0.0172071475843812 |1511 |10287 |PSMD1,ABCF1,PSMC5,PSMD9,PSME3,PSMF1,PSMD3,ABCA7,PSMB11,ABCC3,PSMB3,ABCB10,PSMD7,ABCA4,ABCB6,PSMD14,PSMA6,RPS27A,EIF2S2,ABCA5,ERLEC1,PSMD12,DERL1,UBA52,PSMB10,ABCD3 R-HSA-400253 |Circadian Clock |0.00566726661319193 |-5.17304835628195|71 |19 |0.0125744540039709 |1511 |10287 |CRY1,NRIP1,NPAS2,MIR1281,MED1,UBA52,RPS27A,BHLHE40,MEF2D,NAMPT,ATF2,CREB1,CSNK1D,NR1D1,RAI1,PPARGC1A,CARM1,RXRA,DBP R-HSA-162909 |Host Interactions of HIV factors |0.00584131516157629 |-5.14279930859542|134 |31 |0.0205162144275314 |1511 |10287 |XPO1,PSMD7,PSMB3,NUP54,PSMA6,PPIA,NUP42,NPM1,PSMD14,AAAS,NDC1,RPS27A,KPNB1,UBA52,PSMB10,CD28,PSMD12,AP2M1,PSMD1,AP1S3,NUP210,CCNT1,PSMD9,PSMC5,PSME3,PSMD3,HCK,PSMF1,PSMB11,RAE1,HMGA1 R-HSA-193704 |p75 NTR receptor-mediated signalling |0.00602915866937129 |-5.11114780212814|97 |24 |0.0158835208471211 |1511 |10287 |FGD2,VAV2,ARHGEF40,AATF,ARHGEF3,PSEN2,SQSTM1,VAV3,SOS1,ARHGDIA,MIR7706,ARHGEF1,PREX1,NGEF,NGFR,NFKBIA,RELA,PLEKHG2,UBA52,MCF2L,RTN4,HDAC2,GNA13,RPS27A R-HSA-69017 |CDK-mediated phosphorylation and removal of Cdc6 |0.0063403802145024 |-5.06081654158947|52 |15 |0.0099272005294507 |1511 |10287 |PSMD3,RPS27A,PSMF1,PSMD12,UBA52,PSMB10,PSMB11,PSMB3,PSMD1,PSMD7,PSMD14,PSMC5,PSME3,PSMD9,PSMA6 R-HSA-69304 |Regulation of DNA replication |0.00659803721060721 |-5.02098306651187|77 |20 |0.0132362673726009 |1511 |10287 |PSME3,PSMC5,PSMD9,E2F1,PSMD1,PSMB11,PSMD3,PSMF1,PSMA6,CDT1,ORC2,PSMD14,E2F3,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,RPS27A,GMNN R-HSA-5678895|Defective CFTR causes cystic fibrosis |0.00664555416738575 |-5.01380719414886|62 |17 |0.0112508272667108 |1511 |10287 |PSMF1,PSMD3,PSMB11,PSMD1,PSMC5,PSMD9,PSME3,RPS27A,ERLEC1,PSMD12,PSMB10,DERL1,UBA52,PSMB3,PSMD7,PSMD14,PSMA6 R-HSA-162906 |HIV Infection |0.00666009603923901 |-5.01162137422765|236 |49 |0.0324288550628723 |1511 |10287 |PSMB11,HMGA1,RAE1,TAF4,CHMP6,PSMC5,PSMD9,CD28,UBA52,GTF2H5,PSMB10,GTF2E2,RPS27A,VPS4A,NUP42,PPIA,CHMP3,CHMP4B,AAAS,NPM1,XPO1,PSMB3,ELL,FURIN,CHMP4A,POLR2D,HCK,PSMF1,PSMD3,PDCD6IP,GTF2H1,AP1S3,PSME3,CCNT1,NUP210,PSMD1,AP2M1,XRCC5,PSMD12,NDC1,TBP,KPNB1,PSMA6,SUPT5H,PSMD14,PSMD7,GTF2A2,POLR2A,NUP54 R-HSA-5358346|Hedgehog ligand biogenesis |0.0066841262631928 |-5.00801977806344|67 |18 |0.0119126406353408 |1511 |10287 |PSMF1,PSMD3,PSMB11,PSMD1,SHH,PSME3,PSMD9,PSMC5,RPS27A,ERLEC1,NOTUM,PSMD12,PSMB10,UBA52,PSMB3,PSMD7,PSMD14,PSMA6 R-HSA-1234176|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |0.0066841262631928 |-5.00801977806344|67 |18 |0.0119126406353408 |1511 |10287 |PSMD3,PSMF1,AJUBA,PSMB11,PSMD1,PSMD9,PSME3,PSMC5,EPAS1,RPS27A,PSMD12,EGLN3,UBA52,PSMB10,PSMB3,PSMD7,PSMD14,PSMA6 R-HSA-416482 |G alpha (12/13) signalling events |0.00733407356607504 |-4.9152241785577 |88 |22 |0.014559894109861 |1511 |10287 |ADRA1D,RHOC,PREX1,ARHGEF1,NGEF,PLXNB1,GNA13,PLEKHG2,GNB5,MCF2L,VAV2,ARHGEF40,GNGT2,PIK3R1,ARHGEF3,ROCK2,FGD2,RHOB,SOS1,GNB1,MIR7706,VAV3 R-HSA-5357801|Programmed Cell Death |0.00753075102684761 |-4.88876050418266|175 |38 |0.0251489080079418 |1511 |10287 |PSME3,GSN,YWHAG,E2F1,PSMD1,DNM1L,DSP,RIPK1,CFLAR,PSMF1,PSMD3,OMA1,CYCS,PSMA6,GZMB,PSMD14,DYNLL2,PSMD7,BCL2L1,UNC5A,ACIN1,PSMD12,SFN,KPNB1,PRKCD,PSMD9,PSMC5,HIST1H1A,PSMB11,LMNA,CTNNB1,PSMB3,PSMB10,UBA52,LMNB1,RPS27A,BMF,HIST1H1E R-HSA-180534 |Vpu mediated degradation of CD4 |0.00767026794488904 |-4.87040373006856|53 |15 |0.0099272005294507 |1511 |10287 |PSMA6,PSMD14,PSME3,PSMC5,PSMD9,PSMD7,PSMB3,PSMD1,PSMB10,UBA52,PSMB11,PSMD12,PSMD3,RPS27A,PSMF1 R-HSA-349425 |Autodegradation of the E3 ubiquitin ligase COP1 |0.00767026794488904 |-4.87040373006856|53 |15 |0.0099272005294507 |1511 |10287 |PSMD14,PSMD9,PSMC5,PSME3,PSMA6,PSMB3,PSMD1,PSMD7,PSMD12,UBA52,PSMB10,PSMB11,PSMD3,RPS27A,PSMF1 R-HSA-421837 |Clathrin derived vesicle budding |0.00780011913583831 |-4.85361627157781|73 |19 |0.0125744540039709 |1511 |10287 |CTSZ,SNX9,FTH1,CLTC,STX4,ARRB1,TFRC,TGOLN2,AP1G2,ACBD3,BLOC1S4,AP4S1,SNAP23,FTL,DNM2,TXNDC5,DTNBP1,AP1S3,SNX5 R-HSA-174178 |APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |0.00780011913583831 |-4.85361627157781|73 |19 |0.0125744540039709 |1511 |10287 |UBE2C,PSME3,PSMC5,PSMD9,AURKA,PSMD1,PSMB11,PSMF1,PSMD3,ANAPC5,PSMA6,PSMD14,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,ANAPC11,RPS27A R-HSA-199992 |trans-Golgi Network Vesicle Budding |0.00780011913583831 |-4.85361627157781|73 |19 |0.0125744540039709 |1511 |10287 |SNAP23,AP4S1,BLOC1S4,SNX5,AP1S3,DTNBP1,TXNDC5,DNM2,FTL,STX4,CLTC,FTH1,SNX9,CTSZ,ACBD3,TGOLN2,AP1G2,TFRC,ARRB1 R-HSA-174154 |APC/C:Cdc20 mediated degradation of Securin |0.00787335080687555 |-4.84427153755129|68 |18 |0.0119126406353408 |1511 |10287 |PSMA6,PSMD14,PSMD7,PSMB3,UBA52,PSMB10,PSMD12,ANAPC11,RPS27A,UBE2C,PSME3,PSMC5,PSMD9,PSMD1,PSMB11,PSMF1,PSMD3,ANAPC5 R-HSA-166520 |Signalling by NGF |0.00866399010559361 |-4.74857991129776|477 |89 |0.0589013898080741 |1511 |10287 |SHC2,AGO1,PLEKHG2,PRKAR1A,DUSP3,UBA52,LAMTOR2,ARRB1,NFKBIA,PSMB3,GRB2,MAPKAPK3,SOS1,MIR7706,MAPKAP1,ITPR3,VAV2,ARHGEF40,ARHGEF3,PSEN2,PRKCD,PSMD9,PDGFB,GNA13,CLTC,PSMD7,RALB,WDR83,NGFR,RELA,TRIB3,FGF17,PSMD14,ARHGDIA,MAPK14,PSMF1,PSMD3,VAV3,RALGDS,FN1,PIK3R1,CREB1,SPTBN1,DNM2,KSR1,TNRC6A,RPS27A,CD28,GSK3B,PSMB10,MCF2L,RTN4,AKAP9,PREX1,ADCY4,NGEF,PRKAR2A,SRC,ERBB2,SPTBN2,PSMB11,MOV10,PSMC5,SPRED2,HDAC2,AP2M1,PSMD12,PTPRA,PCSK6,ARHGEF1,PSMA6,RASGRF1,MAPKAPK2,DUSP9,PIK3AP1,FURIN,SQSTM1,PRKCE,TNRC6C,AATF,INSR,PSMD1,PRKACA,ERBB3,FGFR3,GRIN2A,PSME3,PPP2CA,FGD2 R-HSA-400206 |Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |0.00904185463879796 |-4.70589096646125|127 |29 |0.0191925876902713 |1511 |10287 |MED23,ACADM,MED9,NR1D1,NFYC,PPARGC1A,CARM1,RXRA,ABCA1,TEAD4,AGT,ESRRA,CCN2,TRIB3,NCOA3,NCOR2,NPAS2,TEAD3,MED1,FAM120B,PPARG,MIR1281,APOA2,ACOX1,SP1,MED15,MED11,MTF1,FADS1 R-HSA-69610 |p53-Independent DNA Damage Response |0.00921336367502549 |-4.68710027551899|54 |15 |0.0099272005294507 |1511 |10287 |PSMD1,PSMB3,PSMD7,PSMC5,PSMD9,PSME3,PSMD14,PSMA6,PSMF1,RPS27A,PSMD3,PSMD12,PSMB11,UBA52,PSMB10 R-HSA-69601 |Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |0.00921336367502549 |-4.68710027551899|54 |15 |0.0099272005294507 |1511 |10287 |RPS27A,PSMD3,PSMF1,PSMD12,PSMB10,UBA52,PSMB11,PSMB3,PSMD1,PSMD7,PSMD14,PSMC5,PSMD9,PSME3,PSMA6 R-HSA-1592230|Mitochondrial biogenesis |0.00921336367502549 |-4.68710027551899|54 |15 |0.0099272005294507 |1511 |10287 |ATF2,CREB1,MEF2D,TFB1M,POLG2,ESRRA,CYCS,RXRA,TFAM,CARM1,MAPK14,PPARGC1A,ATP5F1B,NR1D1,MED1 R-HSA-69613 |p53-Independent G1/S DNA damage checkpoint |0.00921336367502549 |-4.68710027551899|54 |15 |0.0099272005294507 |1511 |10287 |PSMD12,PSMB11,UBA52,PSMB10,PSMF1,PSMD3,RPS27A,PSMD9,PSME3,PSMC5,PSMD14,PSMA6,PSMD1,PSMB3,PSMD7 R-HSA-174084 |Autodegradation of Cdh1 by Cdh1:APC/C |0.00930672370705221 |-4.6770181607936 |64 |17 |0.0112508272667108 |1511 |10287 |UBE2C,PSME3,PSMC5,PSMD9,PSMD1,PSMF1,ANAPC5,PSMD3,PSMA6,PSMD14,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,ANAPC11,RPS27A R-HSA-5607764|CLEC7A (Dectin-1) signaling |0.0101585761487967 |-4.5894369894877 |101 |24 |0.0158835208471211 |1511 |10287 |PRKCD,PSMD9,PSME3,PSMC5,PSMD1,PSMB11,ITPR3,NFATC3,CARD9,SRC,PSMF1,PSMD3,PSMA6,PSMD14,PSMD7,NFATC2,NFKBIA,PSMB3,CDC34,RELA,PSMB10,UBA52,PSMD12,RPS27A R-HSA-2559583|Cellular Senescence |0.0108548018569391 |-4.52314772943993|196 |41 |0.0271343481138319 |1511 |10287 |E2F3,CDKN2A,MAPKAPK3,HIST1H4C,TERF2,AGO1,ANAPC11,LMNB1,RPS27A,HIST1H1E,TNRC6A,UBA52,MOV10,HIST1H1A,ASF1A,CDK4,ACD,CEBPB,JUN,NBN,TXN,HIST1H2BN,CBX4,HMGA1,ID1,MAP2K7,RELA,MAPK9,SP1,MAP4K4,TERF2IP,MAP3K5,E2F1,TNRC6C,UBE2C,MDM4,CDK6,HIST1H2BI,MAPK14,MAPKAPK2,ANAPC5 R-HSA-1655829|Regulation of cholesterol biosynthesis by SREBP (SREBF) |0.0109919952574539 |-4.51058797495658|55 |15 |0.0099272005294507 |1511 |10287 |NFYC,MBTPS1,MED1,SCAP,ELOVL6,CARM1,SP1,RXRA,KPNB1,MTF1,PMVK,TM7SF2,FASN,DHCR7,MVK R-HSA-180585 |Vif-mediated degradation of APOBEC3G |0.0109919952574539 |-4.51058797495658|55 |15 |0.0099272005294507 |1511 |10287 |PSMD7,PSMB3,PSMD1,PSMA6,PSMD14,PSME3,PSMD9,PSMC5,PSMD3,RPS27A,PSMF1,UBA52,PSMB10,PSMB11,PSMD12 R-HSA-3700989|Transcriptional Regulation by TP53 |0.0113898182183448 |-4.47503546140942|367 |70 |0.0463269358041032 |1511 |10287 |STEAP3,MAPKAP1,TP53RK,TAF4,NBN,ATF2,RBL2,UBA52,GTF2H5,LAMTOR2,AGO1,PRDX5,SMYD2,NPM1,CDKN2A,RABGGTA,ELL,PRMT1,RMI2,CARM1,MAPK14,PERP,MDM4,GTF2H1,JMY,CCNT1,YWHAG,E2F1,ARID3A,AURKA,SFN,TP53I3,HUS1,GATAD2A,SCO1,TOPBP1,POLR2A,TOP3A,USP7,JUN,TXN,COX5B,MOV10,CNOT11,TNRC6A,BIRC5,RPS27A,LAMTOR5,CASP10,BRIP1,PHF20,NUAK1,POLR2D,ING5,RBL1,DDIT4,PRMT5,BANP,PPP2CA,TNRC6C,MIR1281,COX4I1,CRADD,TBP,HDAC2,CSNK2B,L3MBTL1,CYCS,NDRG1,SUPT5H R-HSA-1989781|PPARA activates gene expression |0.011863062700859 |-4.43432568090375|124 |28 |0.0185307743216413 |1511 |10287 |RXRA,CARM1,PPARGC1A,ACADM,MED9,NR1D1,NFYC,MED23,MED11,MTF1,FADS1,SP1,MED15,ACOX1,APOA2,MED1,FAM120B,MIR1281,PPARG,TEAD3,NPAS2,NCOA3,AGT,ESRRA,TEAD4,ABCA1,CCN2,TRIB3 R-HSA-204998 |Cell death signalling via NRAGE, NRIF and NADE |0.012171019455789 |-4.40869760755439|76 |19 |0.0125744540039709 |1511 |10287 |RPS27A,GNA13,UBA52,PLEKHG2,MCF2L,NGFR,PREX1,ARHGEF1,NGEF,SOS1,MIR7706,SQSTM1,VAV3,ARHGEF40,AATF,VAV2,ARHGEF3,PSEN2,FGD2 R-HSA-69656 |Cyclin A:Cdk2-associated events at S phase entry |0.0124915172944903 |-4.38270548147902|71 |18 |0.0119126406353408 |1511 |10287 |CDK4,PSMD1,PSMC5,PSMD9,PSME3,PSMD3,PSMF1,PTK6,CDC25B,PSMB3,PSMD7,PSMD14,WEE1,PSMA6,RPS27A,PSMD12,PSMB10,UBA52 R-HSA-1428517|The citric acid (TCA) cycle and respiratory electron transport |0.0126490061427478 |-4.37017663268575|158 |34 |0.0225016545334216 |1511 |10287 |NDUFB9,LDHAL6B,NDUFS5,NDUFAB1,ATP5MC1,NDUFS7,MPC1,COX5B,NDUFB2,UQCRC2,COQ10B,ATP5MC3,ETFA,ATP5ME,ATP5MC2,LDHA,NDUFV2,ACO2,NDUFS6,MIR6787,NDUFAF6,SUCLG2,RXRA,NDUFAF5,ATP5F1D,NDUFA7,ATP5PF,ATP5F1B,SUCLA2,COX4I1,SLC16A3,SCO1,CYCS,PDK2 R-HSA-5607761|Dectin-1 mediated noncanonical NF-kB signaling |0.0129424125600882 |-4.34724556524054|61 |16 |0.0105890138980807 |1511 |10287 |PSMD1,PSME3,PSMC5,PSMD9,PSMF1,PSMD3,PSMB11,PSMD7,RELA,PSMB3,PSMA6,PSMD14,RPS27A,UBA52,PSMB10,PSMD12 R-HSA-187577 |SCF(Skp2)-mediated degradation of p27/p21 |0.0129424125600882 |-4.34724556524054|61 |16 |0.0105890138980807 |1511 |10287 |PSMD3,PTK6,PSMF1,CDK4,PSMD1,PSMC5,PSMD9,PSME3,RPS27A,UBA52,PSMB10,PSMD12,PSMD7,PSMB3,PSMA6,PSMD14 R-HSA-8852276|The role of GTSE1 in G2/M progression after G2 checkpoint |0.0129424125600882 |-4.34724556524054|61 |16 |0.0105890138980807 |1511 |10287 |PSMD9,PSMC5,PSME3,PSMD1,PSMB11,PSMF1,PSMD3,HSP90AB1,PSMA6,PSMD14,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,RPS27A R-HSA-1640170|Cell Cycle |0.0135343463867042 |-4.30252464768374|621 |111 |0.0734612839179351 |1511 |10287 |CENPX,UBE2C,HIST1H2BI,PSME3,CDK6,PPP2CA,NUP210,PSMD1,RUVBL1,PRKACA,BRIP1,CDC25B,AJUBA,HJURP,RBL1,ANAPC5,ORC2,WEE1,PSMA6,HAUS8,STAG2,PRIM2,LPIN3,TERF2IP,MIR1281,TUBGCP6,PSMD12,CENPM,NDC1,CSNK2B,GMNN,RFC1,ACD,CKAP5,PSMC5,CLASP2,PSMB11,POLE2,HIST1H2BN,NEK9,PTK6,MSH5,AKAP9,NUP42,HSP90AB1,CEP63,PCM1,AAAS,PPP1R12B,E2F3,WAPL,MYBL2,PSMB10,REC8,LMNB1,UIMC1,RPS27A,BIRC5,MDM4,YWHAG,E2F1,AURKA,CSNK1D,SGO2,RMI2,CEP250,PHLDA1,RNF8,PSMF1,PSMD3,TUBA4A,RSF1,NDEL1,PSMD14,PSMD7,TOPBP1,NUP54,TOP3A,NSD2,RAD51C,SFN,CENPU,HUS1,PSMD9,FBXO5,UBE2I,NBN,NINL,CDK4,HAUS4,RAE1,TUBGCP3,LEMD2,DIDO1,LMNA,GINS3,CDT1,HIST1H4C,NPM1,CDKN2A,ALMS1,XPO1,PSMB3,RBL2,UBA52,SET,GORASP2,ANAPC11,CCP110,TERF2,TYMS R-HSA-2426168|Activation of gene expression by SREBF (SREBP) |0.0150314011374456 |-4.19761385684461|42 |12 |0.00794176042356056 |1511 |10287 |ELOVL6,MED1,NFYC,MTF1,RXRA,SP1,CARM1,FASN,TM7SF2,PMVK,MVK,DHCR7 R-HSA-6782315|tRNA modification in the nucleus and cytosol |0.0150314011374456 |-4.19761385684461|42 |12 |0.00794176042356056 |1511 |10287 |DUS2,ADAT3,TP53RK,ADAT2,FTSJ1,PUS7,TRMT10A,TRMT11,TYW5,METTL1,WDR4,TRMT6 R-HSA-453279 |Mitotic G1-G1/S phases |0.0150978485928527 |-4.19320302260664|143 |31 |0.0205162144275314 |1511 |10287 |RPS27A,TYMS,PSMB10,UBA52,MYBL2,RBL2,PSMD12,E2F3,PRIM2,PSMD7,CDKN2A,PSMB3,WEE1,PSMA6,CDT1,ORC2,PSMD14,RBL1,PSMD3,PTK6,PSMF1,POLE2,E2F1,CDK4,PSMD1,CDK6,PSMD9,PSME3,FBXO5,PSMC5,PPP2CA R-HSA-195253 |Degradation of beta-catenin by the destruction complex |0.0154292731819579 |-4.17148871793181|83 |20 |0.0132362673726009 |1511 |10287 |PSMA6,PSMD14,PSMD7,CTNNB1,PSMB3,GSK3B,PSMB10,UBA52,PSMD12,RPS27A,CTBP1,PSMD9,PSMC5,PSME3,PPP2CA,PSMD1,TCF7L2,PSMB11,PSMF1,PSMD3 R-HSA-350562 |Regulation of ornithine decarboxylase (ODC) |0.0154328323990283 |-4.17125806503116|52 |14 |0.00926538716082065 |1511 |10287 |PSMD3,PSMF1,PSMD12,PSMB10,PSMB11,PSMB3,ODC1,PSMD1,PSMD7,PSMD14,PSME3,PSMD9,PSMC5,PSMA6 R-HSA-72203 |Processing of Capped Intron-Containing Pre-mRNA |0.0156051193341233 |-4.16015625611636|247 |49 |0.0324288550628723 |1511 |10287 |SNRNP48,LSM2,NDC1,WDR33,SF3B6,PUF60,HNRNPA3,DDX42,TXNL4A,NUP54,POLR2A,EIF4E,METTL3,SNRPA,PRPF31,EFTUD2,CASC3,WTAP,SNRPC,POLR2D,LSM5,HNRNPF,HNRNPH1,SNRPB,NUP210,EIF4A3,WBP4,DDX46,SNRPB2,SRSF10,HNRNPD,SRRM2,AAAS,CD2BP2,GCFC2,SRSF6,NUP42,SNRNP200,PRPF6,CPSF1,RAE1,HNRNPUL1,THOC7,RNPS1,LSM4,CRNKL1,CHERP,SRRT,SLBP R-HSA-174184 |Cdc20:Phospho-APC/C mediated degradation of Cyclin A |0.0166048600002245 |-4.09805985537087|73 |18 |0.0119126406353408 |1511 |10287 |PSMD14,PSMA6,PSMB3,PSMD7,PSMD12,PSMB10,UBA52,RPS27A,ANAPC11,PSMD9,PSMC5,PSME3,UBE2C,PSMD1,PSMB11,ANAPC5,PSMD3,PSMF1 R-HSA-194138 |Signaling by VEGF |0.0174759837757593 |-4.04692769626604|338 |64 |0.042356055592323 |1511 |10287 |NRP2,PSMF1,PSMD3,MAPK14,VAV3,PIK3R1,FN1,SPTBN1,PDGFB,CYBA,HSPB1,PSMD7,WDR83,FGF17,PSMD14,TRIB3,MAPKAP1,SOS1,JUP,ITPR3,ROCK2,NCK2,VAV2,PSMD9,PRKCD,SHC2,LAMTOR2,UBA52,BCAR1,VEGFA,PSMB3,SPHK1,ARRB1,MAPKAPK3,GRB2,RASGRF1,MAPKAPK2,NCKAP1,DUSP9,WASF2,PSMD1,ERBB3,PRKACA,FGFR3,PPP2CA,PSME3,GRIN2A,SPRED2,PSMD12,PTPRA,PGF,ELMO2,PSMA6,ERBB2,SPTBN2,SRC,PSMB11,PSMC5,KSR1,RPS27A,PSMB10,PTK2B,CTNNB1,AKAP9 R-HSA-5655302|Signaling by FGFR1 in disease |0.0176795796392053 |-4.03534499811834|38 |11 |0.00727994705493051 |1511 |10287 |SOS1,STAT1,TRIM24,STAT5A,LRRFIP1,PIK3R1,MYO18A,STAT5B,FGF17,CUX1,GRB2 R-HSA-1368108|BMAL1:CLOCK,NPAS2 activates circadian gene expression |0.0182947149289472 |-4.00114306254288|48 |13 |0.0086035737921906 |1511 |10287 |NRIP1,NAMPT,CRY1,NPAS2,CREB1,PPARGC1A,MIR1281,NR1D1,MED1,DBP,RXRA,BHLHE40,CARM1 R-HSA-174824 |Lipoprotein metabolism |0.0190212748149961 |-3.96219719913746|74 |18 |0.0119126406353408 |1511 |10287 |PRKACA,APOE,APOB,FURIN,ANGPTL8,MBTPS1,PCSK6,RELN,HDLBP,ABCA1,APOA2,PLTP,AP2M1,SCARB1,LCAT,APOC3,CLTC,LSR R-HSA-69300 |Removal of licensing factors from origins |0.0190212748149961 |-3.96219719913746|74 |18 |0.0119126406353408 |1511 |10287 |PSMD7,PSMB3,ORC2,CDT1,PSMA6,PSMD14,RPS27A,GMNN,PSMB10,UBA52,PSMD12,PSMD1,PSME3,PSMD9,PSMC5,PSMF1,PSMD3,PSMB11 R-HSA-179419 |APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |0.0190212748149961 |-3.96219719913746|74 |18 |0.0119126406353408 |1511 |10287 |PSMD14,PSMA6,PSMB3,PSMD7,PSMD12,PSMB10,UBA52,RPS27A,ANAPC11,PSMD9,PSMC5,PSME3,UBE2C,PSMD1,PSMB11,PSMF1,ANAPC5,PSMD3 R-HSA-199991 |Membrane Trafficking |0.0191054693531268 |-3.95778063135406|610 |108 |0.071475843812045 |1511 |10287 |TGFA,COPS6,SH3GL1,TBC1D16,SRC,SPTBN2,ITSN2,KIF22,SYT8,TF,TRAPPC2L,AP4S1,GGA3,DENND6B,COPB2,RAB3IP,COG1,RAB8B,COG2,TFRC,NBAS,RPS27A,GABARAPL2,FTH1,RALGAPA2,COG7,ULK1,GJC2,SNX5,CUX1,KIF18B,VTI1A,COPS8,GOLGA4,CYTH1,RAB33B,CHMP4A,APOB,EPN1,DYNLL2,ARF6,TRAPPC12,DENND6A,COPS7B,MYO1C,CTSZ,ARF3,GPS1,SYNJ2,GGA2,ARFGAP3,ASPSCR1,AP2M1,RAB3GAP1,TXNDC5,RAB10,TRAPPC5,TRAPPC6B,CHMP6,MCFD2,ACTR3,SCFD1,BLOC1S4,CYTH2,COPG1,GCC1,ARRB1,STAM2,ACBD3,TBC1D14,GRB2,CHMP3,CHMP4B,RAB5B,LNPEP,VPS4A,UBA52,SNX9,YWHAG,EXOC2,GOSR2,SPTBN1,DNM2,C2CD5,FTL,CSNK1D,AP1S3,GAPVD1,DTNBP1,VPS54,SNAP23,TRIP10,VPS36,AGPAT3,MON1A,LMAN1L,MAN1A1,RABGEF1,TGOLN2,AP1G2,STX16,GALNT2,MIA2,SFN,BIN1,GRK3,CLTC,STX4 R-HSA-5610787|Hedgehog 'off' state |0.0192502607556684 |-3.95023067259108|101 |23 |0.0152217074784911 |1511 |10287 |PSMD3,PSMF1,PRKAR2A,PSMB11,PRKACA,PSMD1,MKS1,PSMC5,IFT52,PSME3,PSMD9,RPS27A,PSMD12,PSMB10,UBA52,PRKAR1A,GSK3B,ITCH,PSMB3,PSMD7,PSMD14,ADCY4,PSMA6 R-HSA-1236975|Antigen processing-Cross presentation |0.0192502607556684 |-3.95023067259108|101 |23 |0.0152217074784911 |1511 |10287 |RPS27A,LNPEP,CYBA,PSMD12,SEC61B,PSMB10,UBA52,STX4,PSMB3,CALR,PSMD7,PSMD14,PSMA6,PSMD3,PSMF1,PSMB11,SNAP23,PSMD1,ITGB5,HLA-E,PSME3,PSMD9,PSMC5 R-HSA-5619084|ABC transporter disorders |0.0197196049333584 |-3.92614196381368|69 |17 |0.0112508272667108 |1511 |10287 |PSMB11,PSMF1,PSMD3,PSMD9,PSME3,PSMC5,PSMD1,PSMD12,DERL1,PSMB10,UBA52,RPS27A,ERLEC1,PSMD14,PSMA6,PSMB3,PSMD7 R-HSA-1236974|ER-Phagosome pathway |0.0198680519028592 |-3.91864226935575|85 |20 |0.0132362673726009 |1511 |10287 |PSMD1,HLA-E,PSMC5,PSME3,PSMD9,PSMD3,PSMF1,PSMB11,SNAP23,CALR,PSMD7,PSMB3,PSMA6,PSMD14,RPS27A,PSMB10,STX4,UBA52,PSMD12,SEC61B R-HSA-4641258|Degradation of DVL |0.0209261912799979 |-3.86675373328336|59 |15 |0.0099272005294507 |1511 |10287 |PSMD14,PSME3,PSMC5,PSMD9,PSMA6,PSMB3,PSMD1,PSMD7,PSMD12,UBA52,PSMB10,PSMB11,PSMD3,RPS27A,PSMF1 R-HSA-5653656|Vesicle-mediated transport |0.0212533290827703 |-3.85124173316343|650 |114 |0.0754467240238253 |1511 |10287 |LNPEP,VPS4A,RAB5B,SNX9,UBA52,GCC1,CALR,ARRB1,CHMP4B,STAM2,ACBD3,TBC1D14,CHMP3,GRB2,BLOC1S4,MCFD2,ACTR3,SCFD1,COPG1,CYTH2,TRAPPC5,RAB10,TXNDC5,CHMP6,TRAPPC6B,BIN1,GRK3,AMBP,STX16,SFN,GALNT2,MIA2,CLTC,STX4,AGPAT3,MAN1A1,MON1A,LMAN1L,RABGEF1,TGOLN2,AP1G2,VPS54,VPS36,TRIP10,SNAP23,C2CD5,DNM2,FTL,CSNK1D,YWHAG,EXOC2,GOSR2,SPTBN1,APOE,GAPVD1,DTNBP1,AP1S3,NBAS,RPS27A,FTH1,SCARB1,GABARAPL2,RAB3IP,TFRC,RAB8B,COG1,COG2,SYT8,SPTBN2,TF,KIF22,ITSN2,TBC1D16,SRC,DENND6B,GGA3,COPB2,TRAPPC2L,AP4S1,TGFA,COPS6,SH3GL1,GPS1,ARF3,CTSZ,AP2M1,RAB3GAP1,SYNJ2,ARFGAP3,GGA2,ASPSCR1,ARF6,TRAPPC12,DYNLL2,SCARF1,COPS7B,MYO1C,DENND6A,HYOU1,VTI1A,RAB33B,CHMP4A,EPN1,APOB,GOLGA4,COPS8,CYTH1,GJC2,RALGAPA2,COG7,ULK1,KIF18B,CUX1,SNX5 R-HSA-4420097|VEGFA-VEGFR2 Pathway |0.0222342460474292 |-3.80612156396275|330 |62 |0.0410324288550629 |1511 |10287 |GRB2,AKAP9,MAPKAPK3,CTNNB1,ARRB1,SPHK1,PSMB3,VEGFA,BCAR1,PTK2B,UBA52,PSMB10,LAMTOR2,SHC2,RPS27A,KSR1,PRKCD,PSMC5,PSMD9,VAV2,ROCK2,NCK2,ITPR3,PSMB11,SRC,JUP,SOS1,ERBB2,SPTBN2,MAPKAP1,ELMO2,PSMA6,TRIB3,PSMD14,FGF17,PTPRA,PSMD7,WDR83,HSPB1,PSMD12,CYBA,SPRED2,PDGFB,GRIN2A,PSME3,PPP2CA,SPTBN1,PIK3R1,FN1,FGFR3,PSMD1,ERBB3,PRKACA,WASF2,DUSP9,VAV3,MAPK14,PSMD3,NCKAP1,RASGRF1,MAPKAPK2,PSMF1 R-HSA-2029480|Fcgamma receptor (FCGR) dependent phagocytosis |0.0224286604528541 |-3.79741565346148|86 |20 |0.0132362673726009 |1511 |10287 |ITPR3,WASF2,ACTG1,VAV3,PRKCE,SRC,ACTR3,NCKAP1,HCK,PRKCD,PLD1,VAV2,PIK3R1,WIPF2,ELMO2,GRB2,HSP90AB1,MYO1C,MYH9,NCKIPSD R-HSA-5632684|Hedgehog 'on' state |0.0224286604528541 |-3.79741565346148|86 |20 |0.0132362673726009 |1511 |10287 |PSMA6,GAS8,PSMD14,ARRB1,PSMD7,PSMB3,UBA52,PSMB10,ITCH,PSMD12,RPS27A,SPOP,PSMD9,PSME3,PSMC5,PSMD1,SHH,PSMB11,PSMD3,PSMF1 R-HSA-69580 |p53-Dependent G1/S DNA damage checkpoint |0.0234460701870986 |-3.7530523807731 |65 |16 |0.0105890138980807 |1511 |10287 |PSMD12,PSMB10,UBA52,RPS27A,PSMD14,PSMA6,PSMB3,PSMD7,PSMB11,PSMD3,PSMF1,PSME3,PSMC5,PSMD9,MDM4,PSMD1 R-HSA-69563 |p53-Dependent G1 DNA Damage Response |0.0234460701870986 |-3.7530523807731 |65 |16 |0.0105890138980807 |1511 |10287 |MDM4,PSME3,PSMC5,PSMD9,PSMD1,PSMB11,PSMF1,PSMD3,PSMA6,PSMD14,PSMD7,PSMB3,UBA52,PSMB10,PSMD12,RPS27A R-HSA-176408 |Regulation of APC/C activators between G1/S and early anaphase |0.0235376049399783 |-3.74915592659231|81 |19 |0.0125744540039709 |1511 |10287 |PSMB11,PSMF1,PSMD3,ANAPC5,UBE2C,PSMD9,FBXO5,PSMC5,PSME3,PSMD1,UBA52,PSMB10,PSMD12,ANAPC11,RPS27A,PSMA6,PSMD14,PSMD7,PSMB3 R-HSA-5676590|NIK-->noncanonical NF-kB signaling |0.0242322650931867 |-3.72007026551898|60 |15 |0.0099272005294507 |1511 |10287 |PSMD14,PSME3,PSMD9,PSMC5,PSMA6,PSMB3,PSMD1,PSMD7,PSMD12,PSMB10,UBA52,PSMB11,PSMD3,RPS27A,PSMF1 R-HSA-193648 |NRAGE signals death through JNK |0.0242322650931867 |-3.72007026551898|60 |15 |0.0099272005294507 |1511 |10287 |FGD2,NGEF,PREX1,ARHGEF1,ARHGEF3,AATF,ARHGEF40,VAV2,NGFR,MCF2L,VAV3,PLEKHG2,GNA13,MIR7706,SOS1 R-HSA-176409 |APC/C:Cdc20 mediated degradation of mitotic proteins |0.0246569735909844 |-3.70269551420374|76 |18 |0.0119126406353408 |1511 |10287 |PSMB3,PSMD7,PSMD14,PSMA6,RPS27A,ANAPC11,PSMD12,UBA52,PSMB10,PSMD1,PSME3,PSMC5,PSMD9,UBE2C,ANAPC5,PSMD3,PSMF1,PSMB11 R-HSA-8856828|Clathrin-mediated endocytosis |0.0248120462769601 |-3.69642600676902|137 |29 |0.0191925876902713 |1511 |10287 |ACTR3,TF,SYT8,ITSN2,COPS8,TRIP10,EPN1,APOB,SH3GL1,COPS6,DNM2,GAPVD1,RAB5B,BIN1,RPS27A,GRK3,GPS1,SYNJ2,CLTC,UBA52,AP2M1,SNX9,ARRB1,ARF6,STAM2,GRB2,TGOLN2,COPS7B,TFRC R-HSA-72306 |tRNA processing |0.0251376365907902 |-3.68338909015212|109 |24 |0.0158835208471211 |1511 |10287 |DDX1,ADAT3,DUS2,ADAT2,NDC1,TSEN2,TRMT10A,TYW5,NUP54,AAAS,TRMT6,NUP42,CPSF1,TP53RK,FTSJ1,TSEN15,PRORP,PUS7,RAE1,TRMT11,METTL1,MTO1,WDR4,NUP210 R-HSA-69306 |DNA Replication |0.0251376365907902 |-3.68338909015212|109 |24 |0.0158835208471211 |1511 |10287 |ORC2,CDT1,PSMA6,PSMD14,PSMD7,PRIM2,E2F3,PSMB3,UBA52,PSMB10,PSMD12,RPS27A,GMNN,RFC1,PSME3,PSMC5,PSMD9,E2F1,PSMD1,PSMB11,POLE2,GINS3,PSMF1,PSMD3 R-HSA-174143 |APC/C-mediated degradation of cell cycle proteins |0.0252350131235845 |-3.67952283913518|87 |20 |0.0132362673726009 |1511 |10287 |UBE2C,PSMD9,PSME3,FBXO5,PSMC5,PSMD1,AURKA,PSMB11,PSMF1,ANAPC5,PSMD3,PSMA6,PSMD14,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,ANAPC11,RPS27A R-HSA-453276 |Regulation of mitotic cell cycle |0.0252350131235845 |-3.67952283913518|87 |20 |0.0132362673726009 |1511 |10287 |PSMD12,UBA52,PSMB10,RPS27A,ANAPC11,PSMD14,PSMA6,PSMB3,PSMD7,PSMB11,PSMF1,ANAPC5,PSMD3,PSMD9,PSME3,FBXO5,PSMC5,UBE2C,AURKA,PSMD1 R-HSA-390471 |Association of TriC/CCT with target proteins during biosynthesis |0.0257771248392809 |-3.6582678144835 |40 |11 |0.00727994705493051 |1511 |10287 |MIR1292,XRN2,KIFC3,CCT4,SPHK1,FKBP9,CCT7,ARFGEF2,TCP1,SKIV2L,CCT8 R-HSA-5358351|Signaling by Hedgehog |0.0271537479363804 |-3.60624019659073|138 |29 |0.0191925876902713 |1511 |10287 |PSMA6,GAS8,PSMD14,ADCY4,ARRB1,PSMD7,PSMB3,PSMB10,UBA52,GSK3B,PRKAR1A,ITCH,PSMD12,NOTUM,ERLEC1,RPS27A,SPOP,MKS1,PSME3,PSMC5,PSMD9,IFT52,PRKACA,SHH,PSMD1,PSMB11,PRKAR2A,PSMD3,PSMF1 R-HSA-1852241|Organelle biogenesis and maintenance |0.0278167606361556 |-3.58211653937595|340 |63 |0.0416942422236929 |1511 |10287 |CCT8,HAUS8,POLG2,CYCS,TFB1M,TUBA4A,DYNLRB1,MRPL12,DYNLL2,ATP5F1B,TCTN1,MTIF2,MRPL19,MRPL17,MKS1,IFT52,MRPS5,MRPL33,MEF2D,CSNK1D,PRKACA,CREB1,EXOC2,YWHAG,CEP83,CEP250,RXRA,GADD45GIP1,MAPK14,CARM1,MRPL27,MRPL44,PCM1,MRPS23,ESRRA,CEP63,TCP1,AKAP9,RAB3IP,IFT74,ALMS1,MRPL18,CCT4,TNPO1,MED1,MRPS35,WDR60,MRPS26,TFAM,MRPL53,CCP110,BBS5,CKAP5,MKKS,NINL,ATF2,MRPS18A,PPARGC1A,MRPS9,HAUS4,NR1D1,NPHP4,MRPL58 R-HSA-176814 |Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |0.0279092752241279 |-3.57879620009327|77 |18 |0.0119126406353408 |1511 |10287 |UBE2C,PSMD9,PSMC5,PSME3,PSMD1,PSMB11,ANAPC5,PSMD3,PSMF1,PSMA6,PSMD14,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,ANAPC11,RPS27A R-HSA-390466 |Chaperonin-mediated protein folding |0.0282282172378315 |-3.56743319004521|99 |22 |0.014559894109861 |1511 |10287 |GNB5,CCT4,TUBA1C,CSNK2B,TUBB3,TUBA4A,TCP1,TUBB2A,CCT8,PFDN4,SKIV2L,GNAI3,FKBP9,SPHK1,GNAT1,KIFC3,XRN2,MIR1292,GNB1,GNGT2,ARFGEF2,CCT7 R-HSA-69052 |Switching of origins to a post-replicative state |0.0292779323022842 |-3.53092121047399|72 |17 |0.0112508272667108 |1511 |10287 |PSME3,PSMC5,PSMD9,PSMD1,PSMB11,PSMD3,PSMF1,CDT1,PSMA6,ORC2,PSMD14,PSMD7,PSMB3,PSMB10,UBA52,PSMD12,RPS27A R-HSA-69202 |Cyclin E associated events during G1/S transition |0.0292779323022842 |-3.53092121047399|72 |17 |0.0112508272667108 |1511 |10287 |PSMD7,PSMB3,PSMA6,WEE1,PSMD14,RPS27A,UBA52,PSMB10,PSMD12,CDK4,PSMD1,PSMD9,PSMC5,PSME3,PSMD3,PTK6,PSMF1 R-HSA-68949 |Orc1 removal from chromatin |0.0292779323022842 |-3.53092121047399|72 |17 |0.0112508272667108 |1511 |10287 |PSMB3,PSMD7,PSMD14,ORC2,PSMA6,CDT1,RPS27A,PSMD12,PSMB10,UBA52,PSMD1,PSMC5,PSMD9,PSME3,PSMF1,PSMD3,PSMB11 R-HSA-1168372|Downstream signaling events of B Cell Receptor (BCR) |0.0294408575795618 |-3.52537185580517|197 |39 |0.0258107213765718 |1511 |10287 |RELA,PSMD7,FGF17,PSMD14,TRIB3,PSMA6,PDGFB,PSMD12,PSMD1,ERBB3,FGFR3,PIK3R1,CREB1,TNRC6C,INSR,PPP2CA,PSME3,PSMF1,PSMD3,PIK3AP1,NFKBIA,PSMB3,NFKBIB,GRB2,TNRC6A,RPS27A,AGO1,CD28,GSK3B,UBA52,PSMB10,MOV10,PSMD9,PSMC5,ERBB2,MAPKAP1,SRC,REL,PSMB11 R-HSA-391251 |Protein folding |0.0295369796967658 |-3.52211225163007|105 |23 |0.0152217074784911 |1511 |10287 |GNGT2,ARFGEF2,CCT7,KIFC3,GNAT1,XRN2,MIR1292,GNB1,TUBA4A,TCP1,TUBB2A,SKIV2L,PFDN4,GNAI3,CCT8,SPHK1,TBCD,FKBP9,GNB5,CCT4,TUBA1C,TUBB3,CSNK2B R-HSA-72766 |Translation |0.0295421769951627 |-3.52193630807565|162 |33 |0.0218398411647915 |1511 |10287 |RPL37A,RPS15A,EIF2B4,EIF3D,RPS6,RPL27,RPS14,EIF2B2,EIF5B,APEH,GSPT1,RPN1,EIF3G,RPL9,RPS27A,RPL31,SRP9,UBA52,RPS28,RPS16,RPS26,SRPRA,RPL29,RPS21,SRP68,RPS7,EIF4E,N6AMT1,RPL23,EIF2S2,EEF1B2,RPL18,SEC61B R-HSA-383280 |Nuclear Receptor transcription pathway |0.0297121004058448 |-3.5162008950747 |51 |13 |0.0086035737921906 |1511 |10287 |RARA,NR2F1,NR0B2,ESRRA,NRBP1,HNF4A,RXRB,RXRA,MED1,THRA,NR1D1,PPARG,NR2F6 R-HSA-1227986|Signaling by ERBB2 |0.0297121004058448 |-3.5162008950747 |51 |13 |0.0086035737921906 |1511 |10287 |RPS27A,PTK6,ERBB2,RNF41,SRC,SOS1,GRB7,PRKCE,UBA52,ERBB3,PIK3R1,PRKCD,GRB2 R-HSA-1236978|Cross-presentation of soluble exogenous antigens (endosomes) |0.0297121004058448 |-3.5162008950747 |51 |13 |0.0086035737921906 |1511 |10287 |PSMB10,PSMB11,PSMD12,PSMD3,PSMF1,PSMA6,PSMD14,PSMC5,PSME3,PSMD9,PSMD7,PSMB3,PSMD1 R-HSA-4608870|Asymmetric localization of PCP proteins |0.0306469176668734 |-3.48522318717496|67 |16 |0.0105890138980807 |1511 |10287 |PSMB3,PSMD7,FZD5,PSMD14,PSMA6,RPS27A,PSMD12,PSMB10,UBA52,PSMD1,PSMC5,PSME3,PSMD9,PSMF1,PSMD3,PSMB11 R-HSA-69615 |G1/S DNA Damage Checkpoints |0.0306469176668734 |-3.48522318717496|67 |16 |0.0105890138980807 |1511 |10287 |PSMF1,PSMD3,PSMB11,PSMD1,MDM4,PSMD9,PSMC5,PSME3,RPS27A,UBA52,PSMB10,PSMD12,PSMD7,PSMB3,PSMA6,PSMD14 R-HSA-6807505|RNA polymerase II transcribes snRNA genes |0.0331251149653074 |-3.40746352403098|73 |17 |0.0112508272667108 |1511 |10287 |INTS14,ELL,POLR2A,GTF2A2,SNAPC3,TAF8,GTF2E2,ELL3,ICE2,TBP,SP1,CCNT1,SRRT,INTS12,ZC3H8,INTS2,POLR2D R-HSA-432722 |Golgi Associated Vesicle Biogenesis |0.0332829870604042 |-3.40270891163611|57 |14 |0.00926538716082065 |1511 |10287 |ACBD3,SNX5,TGOLN2,AP1S3,DTNBP1,TFRC,TXNDC5,ARRB1,DNM2,FTL,CLTC,FTH1,SNX9,BLOC1S4 R-HSA-72163 |mRNA Splicing - Major Pathway |0.0334860708553446 |-3.39662572198083|187 |37 |0.0244870946393117 |1511 |10287 |SRSF10,SNRPB2,HNRNPD,SRRM2,SNRNP200,GCFC2,SRSF6,CD2BP2,PRPF6,CPSF1,HNRNPUL1,CRNKL1,LSM4,RNPS1,SRRT,CHERP,WDR33,LSM2,DDX42,TXNL4A,SF3B6,PUF60,HNRNPA3,EFTUD2,PRPF31,SNRPA,POLR2A,SNRPC,CASC3,HNRNPF,LSM5,POLR2D,HNRNPH1,SNRPB,WBP4,DDX46,EIF4A3 R-HSA-1483206|Glycerophospholipid biosynthesis |0.0336875753454779 |-3.39062619371497|129 |27 |0.0178689609530112 |1511 |10287 |CRLS1,CDS2,SLC44A1,AGPAT3,HADHB,LPIN3,GNPAT,GPCPD1,STARD10,SLC44A4,CSNK2B,CHKA,GPD1L,PISD,CPNE7,CPNE1,SARDH,AGPAT1,DGAT1,ABHD4,PTDSS2,PCYT2,PLD1,GPAT2,PITPNM2,STARD7,PITPNM1 R-HSA-373755 |Semaphorin interactions |0.0348045693477606 |-3.35800659772464|68 |16 |0.0105890138980807 |1511 |10287 |HSP90AB1,RHOC,MYH9,PLXNC1,PLXNA2,MYL9,PLXNB1,GSK3B,PLXND1,FARP2,ROCK2,ITGA1,PLXNA1,RHOB,ERBB2,LIMK2 R-HSA-1834949|Cytosolic sensors of pathogen-associated DNA |0.0348045693477606 |-3.35800659772464|68 |16 |0.0105890138980807 |1511 |10287 |NFKBIA,RELA,NFKBIB,CTNNB1,POLR3E,XRCC5,MIR1281,UBA52,RPS27A,CRCP,POLR1C,POLR1D,LRRFIP1,STAT6,POLR3B,RIPK1 R-HSA-2871837|FCERI mediated NF-kB activation |0.0353629189594077 |-3.34209149486273|79 |18 |0.0119126406353408 |1511 |10287 |PSMB11,PSMD3,PSMF1,PSMC5,PSMD9,PSME3,PSMD1,UBA52,PSMB10,PSMD12,RPS27A,PSMA6,PSMD14,PSMD7,RELA,PSMB3,CDC34,NFKBIA R-HSA-1630316|Glycosaminoglycan metabolism |0.0359085576596507 |-3.32677963697406|124 |26 |0.0172071475843812 |1511 |10287 |CEMIP,NDST1,HS3ST3B1,SDC4,CHST13,NAGLU,B3GNT7,B4GALT2,B4GALT3,PAPSS2,B3GNT3,HS3ST3A1,CHPF,HS6ST1,XYLT2,B4GALT5,IDUA,CHP1,B4GALT4,CHST3,B3GNT2,PAPSS1,SDC1,ST3GAL1,ST3GAL2,DSE R-HSA-69242 |S Phase |0.0367818857049135 |-3.30274979127482|130 |27 |0.0178689609530112 |1511 |10287 |RPS27A,PSMD12,UBA52,PSMB10,PSMB3,WAPL,PRIM2,STAG2,PSMD7,PSMD14,CDT1,WEE1,PSMA6,ORC2,PSMD3,PTK6,GINS3,PSMF1,POLE2,CDC25B,PSMB11,CDK4,PSMD1,PSME3,PSMD9,PSMC5,RFC1 R-HSA-163200 |Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.|0.0372169987799229 |-3.2909896656263 |113 |24 |0.0158835208471211 |1511 |10287 |COX4I1,ATP5MC3,ATP5F1B,COQ10B,ATP5MC2,ATP5ME,ETFA,NDUFV2,CYCS,SCO1,NDUFS6,ATP5MC1,NDUFAB1,NDUFS5,NDUFAF6,NDUFB9,NDUFAF5,NDUFS7,ATP5F1D,COX5B,UQCRC2,ATP5PF,NDUFA7,NDUFB2 R-HSA-186763 |Downstream signal transduction |0.0380717785234571 |-3.26828199248806|352 |64 |0.042356055592323 |1511 |10287 |MAPKAP1,SOS1,ITPR3,NCK2,STAT5B,PSMD9,PRKCD,AGO1,SHC2,LAMTOR2,UBA52,PRKAR1A,STAT5A,PSMB3,BCAR1,ARRB1,GRB2,PSMD3,PSMF1,CREB1,SPTBN1,FN1,PIK3R1,PDGFB,STAT1,WDR83,PSMD7,PSMD14,FGF17,TRIB3,SPTBN2,ERBB2,SRC,PRKAR2A,STAT6,PSMB11,MOV10,PSMC5,RPS27A,KSR1,TNRC6A,GRB7,PSMB10,GSK3B,CD28,ADCY4,AKAP9,RASGRF1,PRKCE,PIK3AP1,DUSP9,FGFR3,PRKACA,ERBB3,PSMD1,TNRC6C,INSR,PPP2CA,PSME3,GRIN2A,SPRED2,PSMD12,PTPRA,PSMA6 R-HSA-69206 |G1/S Transition |0.0382820153551877 |-3.26277506605105|119 |25 |0.0165453342157512 |1511 |10287 |POLE2,PSMD3,PSMF1,PTK6,PSMC5,PPP2CA,FBXO5,PSME3,PSMD9,CDK4,PSMD1,E2F1,PSMD12,PSMB10,UBA52,RPS27A,TYMS,PSMD14,PSMA6,CDT1,WEE1,ORC2,PSMB3,PRIM2,PSMD7 R-HSA-72172 |mRNA Splicing |0.0388615714574536 |-3.24774939690416|195 |38 |0.0251489080079418 |1511 |10287 |POLR2D,HNRNPF,LSM5,EIF4A3,DDX46,WBP4,SNRPB,HNRNPH1,DDX42,TXNL4A,HNRNPA3,SF3B6,PUF60,LSM2,SNRNP48,WDR33,SNRPC,CASC3,POLR2A,EFTUD2,PRPF31,SNRPA,HNRNPUL1,PRPF6,CPSF1,CHERP,SRRT,RNPS1,CRNKL1,LSM4,HNRNPD,SNRPB2,SRSF10,SNRNP200,CD2BP2,GCFC2,SRSF6,SRRM2 R-HSA-3858494|Beta-catenin independent WNT signaling |0.0420923682371242 |-3.1678888317544 |149 |30 |0.0198544010589014 |1511 |10287 |PSMD12,AP2M1,UBA52,CLTC,PSMB10,GNB5,RPS27A,TNRC6A,AGO1,PSMD14,FZD5,WNT11,PSMA6,PSMB3,CTNNB1,PSMD7,PLCB1,TCF7L2,PSMB11,ITPR3,PSMD3,PSMF1,GNB1,PSMD9,PSME3,PSMC5,PSMD1,MOV10,TNRC6C,GNGT2 R-HSA-1236394|Signaling by ERBB4 |0.0424934638958069 |-3.15840500556566|43 |11 |0.00727994705493051 |1511 |10287 |GRB2,ERBB3,PSEN2,PIK3R1,ITCH,GFAP,STAT5A,UBA52,RPS27A,WWOX,SOS1 R-HSA-381119 |Unfolded Protein Response (UPR) |0.0434164253828123 |-3.13691744443385|92 |20 |0.0132362673726009 |1511 |10287 |SEC63,SEC61B,GFPT1,HERPUD1,ATP6V0D1,CALR,HSPA5,WFS1,HYOU1,LMNA,PDIA5,CUL7,EXOSC6,MBTPS1,NFYC,IGFBP1,ATF4,GOSR2,SRPRA,ACADVL R-HSA-70326 |Glucose metabolism |0.044182558266526 |-3.11942517713186|81 |18 |0.0119126406353408 |1511 |10287 |PFKL,UGP2,GOT2,PYGB,PCK2,PRKACA,PPP2CA,SLC25A12,PGM2,RPS27A,SLC25A10,PKLR,PHKB,UBA52,SLC25A13,PPP1R3C,GAA,ENO1 R-HSA-5658442|Regulation of RAS by GAPs |0.0443260875787935 |-3.11618189085828|70 |16 |0.0105890138980807 |1511 |10287 |PSMD1,PSMD9,PSMC5,PSME3,PSMD3,PSMF1,PSMB11,PSMB3,PSMD7,PSMD14,PSMA6,RPS27A,SPRED2,PSMD12,PSMB10,UBA52 R-HSA-6781823|Formation of TC-NER Pre-Incision Complex |0.0455824732047504 |-3.08823199589181|54 |13 |0.0086035737921906 |1511 |10287 |COPS6,POLR2A,GTF2H1,COPS7B,XPA,GPS1,RPS27A,UBA52,GTF2H5,MIR1281,COPS8,USP7,POLR2D R-HSA-1169408|ISG15 antiviral mechanism |0.0468853885700462 |-3.06004919641862|76 |17 |0.0112508272667108 |1511 |10287 |AAAS,NUP42,NUP54,EIF4E,FLNB,STAT1,UBA52,KPNA5,KPNB1,RPS27A,NDC1,TRIM25,EIF4A3,KPNA4,NUP210,EIF4E2,RAE1 R-HSA-5619115|Disorders of transmembrane transporters |0.0468853885700462 |-3.06004919641862|76 |17 |0.0112508272667108 |1511 |10287 |PSMB3,PSMD7,PSMD14,PSMA6,RPS27A,ERLEC1,PSMD12,UBA52,PSMB10,DERL1,PSMD1,PSME3,PSMD9,PSMC5,PSMF1,PSMD3,PSMB11 R-HSA-1169410|Antiviral mechanism by IFN-stimulated genes |0.0468853885700462 |-3.06004919641862|76 |17 |0.0112508272667108 |1511 |10287 |UBA52,STAT1,TRIM25,NDC1,KPNB1,KPNA5,RPS27A,NUP42,AAAS,FLNB,EIF4E,NUP54,RAE1,EIF4E2,EIF4A3,KPNA4,NUP210 R-HSA-162599 |Late Phase of HIV Life Cycle |0.048020850282965 |-3.03611998149521|139 |28 |0.0185307743216413 |1511 |10287 |PPIA,CHMP3,NUP42,SUPT5H,AAAS,CHMP4B,XPO1,GTF2A2,ELL,POLR2A,NUP54,UBA52,GTF2H5,GTF2E2,NDC1,VPS4A,RPS27A,TBP,GTF2H1,TAF4,NUP210,CHMP6,CCNT1,FURIN,POLR2D,CHMP4A,RAE1,PDCD6IP R-HSA-1660661|Sphingolipid de novo biosynthesis |0.0494225992384135 |-3.00734748493599|44 |11 |0.00727994705493051 |1511 |10287 |SPHK2,DEGS2,CERS4,ORMDL3,CERS2,CSNK1G2,SPTSSA,SPTSSB,SPHK1,ALDH3B1,PRKD3 R-HSA-168254 |Influenza Infection |0.0495294719061505 |-3.00518739453957|157 |31 |0.0205162144275314 |1511 |10287 |NUP54,POLR2A,CALR,XPO1,RPS7,AAAS,NUP42,RPL31,RPS27A,KPNB1,KPNA5,RPL23,NDC1,RPL9,RPS28,CLTC,RPL18,UBA52,RPS15A,RPS16,RPL37A,RPS14,NUP210,KPNA4,RPS26,RPL27,RPS6,RPL29,RAE1,POLR2D,RPS21 R-HSA-392499 |Metabolism of proteins |0.0495756581952593 |-3.00425532790679|1619 |260 |0.172071475843812 |1511 |10287 |RABGGTA,FKBP9,CDKN2A,PTP4A2,GNAI3,WFS1,EIF3G,TUBB3,CCT4,DERL1,TRAPPC5,CPN1,RAB10,EIF3D,DNAJC19,RPS15A,SLC25A12,EIF2B2,FN3K,TCF7L2,CDC34,LMAN1L,PFDN4,GALNT2,ADRA2C,RAD23B,EDEM2,MDM4,RPS26,OTULIN,MGAT4A,OTUD7B,ALG1,GNB5,RAB40C,RPL27,SPTBN2,HIST1H2BN,PDIA5,USP7,EXOSC6,GNAT1,PSMB11,FOXK2,CCT8,ARF3,RPL23,PSMD1,CCT7,B3GNT7,RPS16,MGAT5,GNB1,RPS21,B3GNT2,ARRB1,CALR,SLC25A13,HIST1H4C,AGT,ACO2,SEC63,RPL31,RPL9,UBA52,PRMT3,UBE2I,RPS14,TRAPPC6B,SCFD1,MCFD2,TIMM17A,COPG1,MBD6,RPS7,EIF4E,TFPT,HSPA5,RAB17,N6AMT1,ASGR2,FUCA1,PIGF,EIF2S2,USP19,INHBC,ST3GAL1,ANPEP,RNF103,DPP4,PIGW,GIP,GSPT1,TCP1,ASGR1,BIRC5,LARGE1,PIGN,PSMB10,GFPT1,RAB37,RPL37A,PSMC5,GALNT16,RAD52,TIMM13,B3GNT3,DAD1,CSNK2B,ST3GAL2,NDC1,UGGT1,ATP5F1B,ARFGAP3,ATF4,RUVBL1,USP37,TGFBR2,COG7,GSN,NUP210,UBE2C,RAB33B,FURIN,PSMB3,NFKBIA,SPHK1,RAB5B,RPS28,THBS2,GNGT2,CKAP4,TOP1,PSMD9,EIF5B,GRPEL1,LMNA,INO80D,GATA4,CUL7,COX19,RAE1,RNF144A,XPNPEP2,MAN1A1,PSMD14,SKIV2L,VDAC2,B4GALT5,EEF1B2,SP3,ST6GALNAC2,ENGASE,FUOM,SEC61B,SMAD7,CSNK1D,AURKA,SPTBN1,EXOC2,CMC2,SRPRA,PSMD3,PSMF1,B4GALT3,MGAT1,ATP6V0D1,COG2,AXIN2,COG1,RAB8B,NUP42,RPS27A,LDHD,B4GALT2,TGFA,RPS6,USP25,B3GNTL1,PROZ,KEAP1,WDR61,ADORA2B,ATP5MC1,USP4,DYNLL2,TUBB2A,TUBA1C,TRIM25,PSMD12,RPL18,GGA2,MIR1281,RNF123,RNF146,HYOU1,SRP68,NFYC,USP47,B4GALT4,STAM2,USP15,SRP9,CCP110,ARFGEF2,PIGC,MIR1292,CBX4,NUP54,TGFBI,IGFBP4,PSMD7,FCSK,TUBA4A,MIA2,USP33,GOSR2,B3GALNT2,ALG2,USP42,RPL29,PIGO,MBTPS1,CTNNB1,INHBE,AAAS,RPN1,PIGU,COQ2,UIMC1,FOXK1,EIF2B4,ASXL1,TXN,ACADVL,ADRM1,EIF5A,XRN2,COPB2,GGA3,APEH,DPH7,TRAPPC2L,KIFC3,IGFBP1,INHA,PROC,HERPUD1,F10,THBS1,TBCD,STAG2,PSMA6,HSPD1,CTSZ,HIST1H2BI,PSME3,SUMF1,RIPK1,GCNT3 R-HSA-186797 |Signaling by PDGF |0.0497960403459933 |-2.99981980923734|376 |67 |0.0443414956982131 |1511 |10287 |SPTBN2,ERBB2,SRC,PRKAR2A,STAT6,PSMB11,MOV10,PSMC5,RPS27A,TNRC6A,KSR1,GRB7,PSMB10,GSK3B,CD28,ADCY4,AKAP9,RASGRF1,PRKCE,PIK3AP1,FURIN,DUSP9,FGFR3,PRKACA,PSMD1,ERBB3,INSR,TNRC6C,PPP2CA,PSME3,GRIN2A,SPRED2,PSMD12,PTPRA,THBS1,PSMA6,MAPKAP1,SOS1,ITPR3,NCK2,STAT5B,PSMD9,PRKCD,AGO1,SHC2,LAMTOR2,UBA52,THBS2,PRKAR1A,STAT5A,PSMB3,BCAR1,ARRB1,GRB2,PSMD3,PSMF1,CREB1,SPTBN1,PIK3R1,FN1,PDGFB,STAT1,WDR83,PSMD7,PSMD14,FGF17,TRIB3 R-HSA-381340 |Transcriptional regulation of white adipocyte differentiation |0.0511200322808173 |-2.97357883744167|88 |19 |0.0125744540039709 |1511 |10287 |CDK4,CEBPD,CEBPB,MED23,CARM1,RXRA,MED9,ZNF638,PPARGC1A,CEBPA,RELA,NCOR2,NCOA3,MED15,MED11,MED1,FAM120B,MIR1281,PPARG R-HSA-168255 |Influenza Life Cycle |0.0524710932542396 |-2.94749286570413|146 |29 |0.0191925876902713 |1511 |10287 |RPL29,RAE1,POLR2D,RPS21,RPS15A,RPS16,RPL37A,RPS14,NUP210,RPS26,RPL27,RPS6,RPL31,KPNB1,RPS27A,RPL23,RPL9,NDC1,RPS28,CLTC,RPL18,UBA52,NUP54,POLR2A,XPO1,RPS7,CALR,AAAS,NUP42 R-HSA-162587 |HIV Life Cycle |0.0529174526475989 |-2.93902207680478|152 |30 |0.0198544010589014 |1511 |10287 |VPS4A,RPS27A,TBP,NDC1,XRCC5,GTF2E2,GTF2H5,UBA52,ELL,POLR2A,NUP54,XPO1,GTF2A2,SUPT5H,CHMP4B,AAAS,CHMP3,PPIA,NUP42,PDCD6IP,CHMP4A,HMGA1,POLR2D,RAE1,FURIN,NUP210,CCNT1,CHMP6,TAF4,GTF2H1 R-HSA-157118 |Signaling by NOTCH |0.0568326316662954 |-2.86764461705048|112 |23 |0.0152217074784911 |1511 |10287 |CREB1,MDK,E2F1,TNRC6C,MOV10,PSEN2,JUN,FURIN,JAG1,ARRB1,E2F3,HDAC10,GZMB,NCOR2,MFNG,AGO1,HDAC2,TNRC6A,RPS27A,MIR1281,ITCH,MIB2,UBA52 R-HSA-6811438|Intra-Golgi traffic |0.0570765578479453 |-2.86336179218721|45 |11 |0.00727994705493051 |1511 |10287 |MAN1A1,GOSR2,COG7,COG2,COG1,CUX1,VTI1A,STX16,RAB33B,CYTH1,CYTH2 R-HSA-8854214|TBC/RABGAPs |0.0570765578479453 |-2.86336179218721|45 |11 |0.00727994705493051 |1511 |10287 |TBC1D14,RABGEF1,RAB8B,ULK1,ARF6,GGA2,GABARAPL2,RAB33B,GGA3,RAB5B,TBC1D16 R-HSA-382551 |Transmembrane transport of small molecules |0.0589737538431658 |-2.83066278416742|677 |114 |0.0754467240238253 |1511 |10287 |SLC30A2,SLC33A1,SLC22A7,SLC6A12,PRKAR1A,UBA52,DERL1,SLC35A3,SLC22A1,SLC25A10,ABCA5,ATP6V0C,ABCG2,ATP6V1E2,SLC47A1,PSMB3,TTYH1,ABCA4,SLCO2B1,RAE1,G6PC3,SLC5A2,AQP3,STEAP3,SLC2A6,SLC50A1,SLC39A4,SLC12A5,MRS2,PSMD9,SLC17A3,ATP8B2,GNGT2,ATP8B3,SLC20A1,SLCO2A1,SLC13A5,EIF2S2,SLC6A11,SLC7A10,PSMD14,SLC16A3,HMOX1,SLC26A6,SLC44A1,NUP54,SLC6A2,SLC38A3,SLC17A7,PSMD7,ASIC4,CLCN3,SLC8A3,ABCA7,SLC2A11,TCIRG1,PSMF1,PSMD3,FTL,SLCO4A1,GNB5,PSMB10,SLC4A2,FTH1,ABCD3,SLC4A9,RPS27A,ATP6V1F,SLC44A4,ADCY4,AAAS,TFRC,SLC4A7,NUP42,SLC1A7,SLC7A7,ATP6V0D1,SLC22A17,ATP6V1B2,ABCB10,CP,ATP11A,PSMB11,TF,PRKAR2A,SLC9A8,SLC13A3,PSMC5,SLC7A5,SGK2,SLC22A16,ABCF1,SLC7A6,SLC12A7,SLC35D1,PSMD12,RHCG,ERLEC1,NDC1,ABCB6,ATP6V1G1,PSMA6,MIR6787,AQP11,ABCC3,GNB1,TRPC4AP,PSME3,NUP210,UNC80,ATP2B2,PRKACA,PSMD1,ATP9A R-HSA-1632852|Macroautophagy |0.0590501263368559 |-2.82936859685154|67 |15 |0.0099272005294507 |1511 |10287 |ULK1,DYNLL2,CHMP3,LAMTOR5,CHMP6,WDR45B,CHMP4B,ATG101,ATG4B,ATG10,ATG5,GABARAPL2,RB1CC1,LAMTOR2,CHMP4A R-HSA-69239 |Synthesis of DNA |0.0595314898765734 |-2.82124986480643|101 |21 |0.013898080741231 |1511 |10287 |PSME3,PSMC5,PSMD9,RFC1,PSMD1,POLE2,PSMB11,PSMD3,GINS3,PSMF1,PSMD14,PSMA6,CDT1,ORC2,PSMB3,PRIM2,PSMD7,PSMD12,PSMB10,UBA52,RPS27A R-HSA-2565942|Regulation of PLK1 Activity at G2/M Transition |0.0620663332170795 |-2.77955157526404|90 |19 |0.0125744540039709 |1511 |10287 |AJUBA,HAUS4,CEP250,CSNK1D,NINL,AURKA,PRKACA,YWHAG,CKAP5,RPS27A,CCP110,UBA52,ALMS1,PPP1R12B,HAUS8,PCM1,CEP63,AKAP9,TUBA4A R-HSA-1268020|Mitochondrial protein import |0.0627152274157176 |-2.76915099933464|62 |14 |0.00926538716082065 |1511 |10287 |COX19,TIMM13,ATP5F1B,ATP5MC1,COQ2,GRPEL1,HSPD1,TIMM17A,LDHD,CMC2,ACO2,SLC25A12,DNAJC19,SLC25A13 R-HSA-72764 |Eukaryotic Translation Termination |0.0636613153308121 |-2.75417819553184|96 |20 |0.0132362673726009 |1511 |10287 |UBA52,RPL18,RPS28,RPS27A,RPL31,RPL9,RPL23,N6AMT1,GSPT1,RPS7,APEH,RPS21,RPL29,RPS14,RPS6,RPL27,RPS26,RPL37A,RPS16,RPS15A R-HSA-2559580|Oxidative Stress Induced Senescence |0.0686452355955122 |-2.67880355055291|126 |25 |0.0165453342157512 |1511 |10287 |CBX4,MAPKAPK2,HIST1H2BN,MAPK14,TXN,HIST1H2BI,CDK6,MDM4,JUN,CDK4,MOV10,TNRC6C,E2F1,MAP3K5,UBA52,TNRC6A,RPS27A,MAP4K4,AGO1,MAPK9,HIST1H4C,MAPKAPK3,CDKN2A,MAP2K7,E2F3 R-HSA-15869 |Metabolism of nucleotides |0.0695987308236774 |-2.66500894710002|97 |20 |0.0132362673726009 |1511 |10287 |ITPA,NME2,DHODH,ENTPD5,APRT,NUDT9,TXN,DCTPP1,NT5C2,ADK,GUK1,ATIC,UPP1,UPP2,TYMP,NT5C,GMPR2,TYMS,ENTPD6,NME1 R-HSA-1226099|Signaling by FGFR in disease |0.0702079327050672 |-2.65629397283788|63 |14 |0.00926538716082065 |1511 |10287 |GRB2,CUX1,FGF17,STAT5B,MYO18A,PIK3R1,FGFR3,LRRFIP1,POLR2A,STAT5A,TRIM24,STAT1,POLR2D,SOS1 R-HSA-446203 |Asparagine N-linked glycosylation |0.0704000422952213 |-2.65356141503393|284 |51 |0.0337524818001324 |1511 |10287 |MGAT5,ALG2,CSNK1D,EDEM2,GOSR2,SPTBN1,COG7,B4GALT3,RNF103,FCSK,FUCA1,ASGR2,B4GALT5,DAD1,MAN1A1,LMAN1L,DYNLL2,RAD23B,ARFGAP3,ST3GAL1,ST3GAL2,ARF3,ENGASE,ST6GALNAC2,CTSZ,UGGT1,MIA2,FUOM,TRAPPC6B,TRAPPC5,TGFA,B4GALT2,COPB2,COPG1,TRAPPC2L,SPTBN2,SCFD1,MCFD2,RPN1,COG2,COG1,ASGR1,B4GALT4,MGAT1,CALR,DERL1,UBA52,ALG1,GFPT1,RPS27A,MGAT4A R-HSA-983705 |Signaling by the B Cell Receptor (BCR) |0.0718304394023777 |-2.63344694565982|229 |42 |0.0277961614824619 |1511 |10287 |NFKBIA,PSMB3,NFKBIB,GRB2,TNRC6A,RPS27A,AGO1,CD28,GSK3B,PSMB10,UBA52,MOV10,PSMD9,PSMC5,MAPKAP1,ERBB2,SOS1,SRC,REL,ITPR3,PSMB11,RELA,PSMD7,FGF17,PSMD14,TRIB3,PSMA6,PDGFB,PSMD12,PSMD1,ERBB3,FGFR3,PIK3R1,TNRC6C,CREB1,INSR,PSME3,PPP2CA,CD79B,PSMF1,PSMD3,PIK3AP1 R-HSA-2408522|Selenoamino acid metabolism |0.0734908822741511 |-2.61059393115009|121 |24 |0.0158835208471211 |1511 |10287 |AHCY,RPS7,UBA52,RPL18,RPS28,PAPSS1,RPL9,RPL23,RPS27A,MAT1A,RPL31,RPS6,RPL27,RPS26,RPS14,RPL37A,RPS16,RPS15A,SCLY,AIMP2,RPS21,PAPSS2,IARS,RPL29 R-HSA-381070 |IRE1alpha activates chaperones |0.0747542850273564 |-2.59354874357366|58 |13 |0.0086035737921906 |1511 |10287 |SEC61B,CUL7,GFPT1,HYOU1,SEC63,PDIA5,LMNA,SRPRA,ACADVL,WFS1,ATP6V0D1,HSPA5,GOSR2 R-HSA-212436 |Generic Transcription Pathway |0.0749834322800577 |-2.59048809278104|865 |142 |0.0939774983454666 |1511 |10287 |PPP2CA,RUNX2,WWOX,RBL1,PRMT5,NDRG1,NR0B2,NCOR2,MIR1281,HDAC2,TBP,ZNF839,NRBP1,TGFA,ZFP69B,MOV10,ZNF771,NR1D1,USP7,TGIF1,ZNF19,ZNF700,ZNF584,CASP10,MED1,ZNF274,TNRC6A,RPS27A,ZNF311,MDM4,JMY,APOE,ZNF433,ARID3A,E2F1,AURKA,PRMT1,ZNF500,CARM1,MAPK14,RXRA,PERP,CCN2,TEAD4,HNF4A,SCO1,GATAD2A,POLR2A,TOP3A,THRA,SMAD7,ZNF552,SFN,NBN,STEAP3,GATA4,ZNF860,MAPKAP1,ESRRA,ZNF343,ZKSCAN8,PRDX5,ZNF775,CDKN2A,ZNF747,RABGGTA,CITED4,RBL2,AGO1,BANP,ZNF720,TNRC6C,BRIP1,PHF20,NUAK1,POLR2D,ZNF710,DDIT4,ING5,L3MBTL1,CYCS,SUPT5H,NR2F1,ZNF337,TEAD3,PPARG,COX4I1,CRADD,SP1,ZNF555,CSNK2B,HSPD1,RXRB,MED23,JUN,TXN,COX5B,ZNF786,ZFP37,ZNF564,ERBB2,ZNF770,LAMTOR5,CITED2,ZSCAN25,ZNF778,MYBL2,CNOT11,BIRC5,GTF2H1,CCNT1,YWHAG,RMI2,ZNF398,RARA,TOPBP1,ZNF517,NR2F6,MED15,ZNF709,TP53I3,HUS1,ZNF77,ZNF624,TAF4,ZFP90,UBE2I,ATF2,SKI,KDM5B,ZNF764,TP53RK,SMYD2,NPM1,ELL,VEGFA,UBA52,GTF2H5,LAMTOR2,ZNF441,ZNF697,ZNF23 R-HSA-202424 |Downstream TCR signaling |0.0759020561111301 |-2.57831150520926|98 |20 |0.0132362673726009 |1511 |10287 |RPS27A,UBA52,PSMB10,PSMD12,PSMD7,CDC34,PSMB3,RELA,NFKBIA,PSMA6,PSMD14,INPP5D,PSMD3,PSMF1,PSMB11,PIK3R1,PSMD1,PSMC5,PSMD9,PSME3 R-HSA-6798695|Neutrophil degranulation |0.0771071965992383 |-2.56255866166331|487 |83 |0.0549305095962938 |1511 |10287 |RAB37,APRT,APEH,ATP11A,PYGB,COMMD3,SERPINB6,CD68,CAND1,ACTR1B,GAA,C1orf35,HSP90AB1,PPIA,PRDX6,CTSB,IST1,FTH1,DGAT1,PSMD1,C6orf120,CSTB,GSN,TMC6,PGM2,KCMF1,C3,MANBA,MMP9,SLPI,CCT8,GSDMD,CSNK2B,KPNB1,CTSZ,CPPED1,ADGRG3,PSMD12,S100P,PA2G4,RAB10,ALDH3B1,TXNDC5,CKAP4,TMBIM1,PRKCD,FUCA2,JUP,ATP6V0C,FRK,DPP7,LGALS3,RHOF,RAB5B,LAMTOR2,VAT1,NME2,FTL,CPNE1,PLD1,STK10,SERPINB1,PFKL,PSMD3,ORMDL3,UNC13D,DSP,MAPK14,ANPEP,SNAP23,TCIRG1,PSMD7,AHSG,PRCP,IDH1,PSMD14,DYNLT1,FUCA1,TMEM30A,CYBA,XRCC5,ITGB2,RNASET2 R-HSA-72695 |Formation of the ternary complex, and subsequently, the 43S complex |0.0795468017523788 |-2.53140972925069|53 |12 |0.00794176042356056 |1511 |10287 |EIF3G,RPS26,RPS6,RPS14,RPS16,RPS15A,RPS7,EIF3D,RPS28,RPS21,EIF2S2,RPS27A R-HSA-72165 |mRNA Splicing - Minor Pathway |0.0795468017523788 |-2.53140972925069|53 |12 |0.00794176042356056 |1511 |10287 |SNRNP48,PRPF6,LSM2,SF3B6,POLR2D,TXNL4A,DDX42,EFTUD2,SNRPB,POLR2A,SRSF6,SNRNP200 R-HSA-3371453|Regulation of HSF1-mediated heat shock response |0.081186784949167 |-2.51100279199066|70 |15 |0.0099272005294507 |1511 |10287 |RAE1,GSK3B,ST13,HSPA4,MAPKAPK2,NDC1,HSPA14,AAAS,NUP210,NUP42,BAG2,DNAJC7,NUP54,HIKESHI,HSPA5 R-HSA-425407 |SLC-mediated transmembrane transport |0.0815402586733162 |-2.50665840924732|287 |51 |0.0337524818001324 |1511 |10287 |SLC26A6,SLC16A3,SLC7A10,SLC38A3,SLC17A7,SLC44A1,SLC6A2,NUP54,SLC35D1,SLC12A7,RHCG,SLC20A1,SLC13A5,SLCO2A1,NDC1,SLC6A11,NUP210,SLCO4A1,MIR6787,SLC8A3,SLC2A11,SLC4A7,AAAS,SLC1A7,NUP42,SLC47A1,SLC7A7,SLCO2B1,CP,SLC22A7,SLC30A2,SLC33A1,SLC4A2,SLC6A12,SLC4A9,SLC35A3,SLC25A10,SLC22A1,SLC44A4,SLC7A5,SLC12A5,SLC7A6,SLC22A16,G6PC3,SLC5A2,RAE1,SLC2A6,SLC39A4,SLC13A3,SLC50A1,SLC9A8 R-HSA-69278 |Cell Cycle, Mitotic |0.081609689168846 |-2.5058072842468 |514 |87 |0.057577763070814 |1511 |10287 |RFC1,CKAP5,PSMC5,CLASP2,PSMB11,POLE2,HIST1H2BN,NEK9,PTK6,NUP42,AKAP9,HSP90AB1,CEP63,PCM1,AAAS,PPP1R12B,E2F3,WAPL,MYBL2,PSMB10,LMNB1,RPS27A,BIRC5,UBE2C,PPP2CA,CDK6,PSME3,HIST1H2BI,NUP210,PSMD1,PRKACA,CDC25B,AJUBA,RBL1,ANAPC5,ORC2,WEE1,PSMA6,HAUS8,STAG2,PRIM2,LPIN3,MIR1281,PSMD12,TUBGCP6,CENPM,NDC1,CSNK2B,GMNN,PSMD9,FBXO5,CDK4,NINL,HAUS4,RAE1,TUBGCP3,LEMD2,LMNA,GINS3,CDT1,HIST1H4C,CDKN2A,XPO1,ALMS1,PSMB3,RBL2,UBA52,SET,GORASP2,ANAPC11,CCP110,TYMS,YWHAG,E2F1,AURKA,CSNK1D,CEP250,SGO2,PHLDA1,PSMF1,PSMD3,TUBA4A,NDEL1,PSMD14,PSMD7,NUP54,CENPU R-HSA-1483257|Phospholipid metabolism |0.0825148447986529 |-2.49477706487485|207 |38 |0.0251489080079418 |1511 |10287 |PNPLA6,GPAT2,PITPNM2,PITPNM1,MTMR2,GDE1,PLEKHA8,PTDSS2,SLC44A4,CPNE7,GPD1L,HADHB,CRLS1,GPCPD1,INPP4A,STARD7,ABHD4,DGAT1,SARDH,CPNE1,PIK3R1,AGPAT1,PCYT2,PLD1,ARF3,CHKA,CSNK2B,PISD,SYNJ2,SLC44A1,GDPD3,AGPAT3,LPIN3,CDS2,INPP5D,STARD10,GNPAT,MTMR4 R-HSA-8856825|Cargo recognition for clathrin-mediated endocytosis |0.082577137190457 |-2.49402242623026|99 |20 |0.0132362673726009 |1511 |10287 |ITSN2,SYT8,TF,APOB,EPN1,COPS8,COPS6,SH3GL1,GPS1,RPS27A,GRK3,AP2M1,CLTC,UBA52,ARRB1,TFRC,COPS7B,TGOLN2,GRB2,STAM2 R-HSA-177929 |Signaling by EGFR |0.0886082541973475 |-2.42353026321218|364 |63 |0.0416942422236929 |1511 |10287 |PSMD3,RASGRF1,PSMF1,EPN1,PRKCE,PIK3AP1,DUSP9,FGFR3,PRKACA,PSMD1,ERBB3,TNRC6C,SPTBN1,INSR,CREB1,PIK3R1,FN1,PSME3,PPP2CA,GRIN2A,SPRED2,PDGFB,PSMD12,PTPRA,WDR83,PSMD7,SPRY2,PSMD14,FGF17,PSMA6,TRIB3,MAPKAP1,SPTBN2,ERBB2,SRC,PRKAR2A,SOS1,ITPR3,PTPN3,PSMB11,MOV10,SH3GL1,PTPRK,PSMD9,PSMC5,PRKCD,RPS27A,KSR1,TNRC6A,AGO1,SHC2,LAMTOR2,PSMB10,UBA52,CD28,GSK3B,PRKAR1A,PSMB3,ARRB1,ADCY4,GRB2,STAM2,AKAP9 R-HSA-5696398|Nucleotide Excision Repair |0.0910878998272325 |-2.39593030651018|112 |22 |0.014559894109861 |1511 |10287 |INO80D,XPA,POLE2,USP7,POLR2D,COPS8,RUVBL1,COPS6,UBE2I,RFC1,GTF2H1,GPS1,RPS27A,RAD23B,GTF2H5,UBA52,MIR1281,ELL,POLR2A,TFPT,COPS7B,USP45 R-HSA-170834 |Signaling by TGF-beta Receptor Complex |0.0918297496435867 |-2.38781896366352|77 |16 |0.0105890138980807 |1511 |10287 |SMAD7,UBA52,USP15,RPS27A,SP1,NCOR2,F11R,MTMR4,BAMBI,XPO1,TGIF1,FURIN,RBL1,CCNT1,SKI,TGFBR2 R-HSA-3371556|Cellular response to heat stress |0.0950587917199937 |-2.35325971858615|89 |18 |0.0119126406353408 |1511 |10287 |NDC1,HSPA4,MIR1281,GSK3B,ST13,HSPA5,NUP54,BAG2,NUP42,HSP90AB1,AAAS,MAPKAPK2,RAE1,HIKESHI,FKBP4,DNAJC7,HSPA14,NUP210 R-HSA-6791312|TP53 Regulates Transcription of Cell Cycle Genes |0.0952766958926939 |-2.35097003240484|49 |11 |0.00727994705493051 |1511 |10287 |AURKA,E2F1,ARID3A,NPM1,CARM1,RBL1,SFN,CNOT11,PRMT1,MIR1281,RBL2 R-HSA-2682334|EPH-Ephrin signaling |0.0961898808683308 |-2.34143111532206|95 |19 |0.0125744540039709 |1511 |10287 |MMP9,VEGFA,MYH9,NGEF,EPHA2,MYL9,AP2M1,EFNA2,CLTC,PSEN2,ROCK2,NCK2,VAV2,MYL12A,ACTR3,SRC,VAV3,LIMK2,ACTG1 R-HSA-72737 |Cap-dependent Translation Initiation |0.0985785189712661 |-2.31690190144054|125 |24 |0.0158835208471211 |1511 |10287 |EIF4E,RPS7,EIF3G,EIF2S2,RPL9,RPL23,RPL31,RPS27A,RPS28,RPL18,UBA52,RPS15A,RPS16,RPL37A,EIF3D,EIF2B4,RPL27,RPS26,RPS6,RPS14,EIF2B2,RPL29,EIF5B,RPS21 R-HSA-72613 |Eukaryotic Translation Initiation |0.0985785189712661 |-2.31690190144054|125 |24 |0.0158835208471211 |1511 |10287 |EIF4E,RPS7,EIF3G,RPS27A,RPL31,RPL9,RPL23,EIF2S2,UBA52,RPL18,RPS28,EIF2B4,EIF3D,RPL37A,RPS16,RPS15A,RPS14,RPS6,RPL27,RPS26,EIF5B,RPL29,EIF2B2,RPS21 R-HSA-5689880|Ub-specific processing proteases |0.100674449440486 |-2.29586324094111|223 |40 |0.0264725347452019 |1511 |10287 |PSMD9,PSMC5,ADRM1,USP25,HIST1H2BN,USP7,KEAP1,PSMB11,USP4,USP47,PSMB3,NFKBIA,ARRB1,STAM2,AXIN2,RPS27A,USP15,CCP110,UBA52,PSMB10,USP33,PSMD1,RUVBL1,RNF123,USP37,PSME3,HIST1H2BI,USP42,MDM4,RNF146,PSMD3,PSMF1,RIPK1,PSMD7,PSMD14,VDAC2,PSMA6,PSMD12,USP19,SMAD7 R-HSA-2555396|Mitotic Metaphase and Anaphase |0.101312406908132 |-2.28954639834532|180 |33 |0.0218398411647915 |1511 |10287 |CENPU,CENPM,PSMD12,STAG2,PSMD7,NDEL1,PSMD14,PSMA6,PSMF1,ANAPC5,PSMD3,SGO2,PSMD1,PPP2CA,PSME3,UBE2C,RPS27A,BIRC5,ANAPC11,LMNB1,UBA52,PSMB10,WAPL,PSMB3,XPO1,LMNA,LEMD2,PSMB11,FBXO5,PSMD9,PSMC5,CLASP2,CKAP5 R-HSA-4086398|Ca2+ pathway |0.103135063194349 |-2.27171585659749|61 |13 |0.0086035737921906 |1511 |10287 |FZD5,WNT11,MOV10,CTNNB1,TNRC6C,GNGT2,ITPR3,TCF7L2,GNB5,PLCB1,AGO1,TNRC6A,GNB1 R-HSA-2029482|Regulation of actin dynamics for phagocytic cup formation |0.103135063194349 |-2.27171585659749|61 |13 |0.0086035737921906 |1511 |10287 |HSP90AB1,GRB2,ELMO2,MYH9,MYO1C,VAV2,NCKIPSD,ACTG1,WASF2,WIPF2,VAV3,ACTR3,NCKAP1 R-HSA-72702 |Ribosomal scanning and start codon recognition |0.103135063194349 |-2.27171585659749|61 |13 |0.0086035737921906 |1511 |10287 |RPS27A,EIF2S2,RPS28,RPS21,EIF3D,RPS15A,RPS16,RPS7,EIF4E,RPS14,RPS26,EIF3G,RPS6 R-HSA-5633007|Regulation of TP53 Activity |0.103312728891119 |-2.26999468788132|162 |30 |0.0198544010589014 |1511 |10287 |AURKA,PPP2CA,BANP,NBN,TAF4,MDM4,JMY,MAPKAP1,PRMT5,TP53RK,ING5,MAPK14,USP7,BRIP1,RMI2,NUAK1,PHF20,TOP3A,CDKN2A,TOPBP1,SMYD2,GATAD2A,L3MBTL1,TBP,HDAC2,RPS27A,CSNK2B,HUS1,MIR1281,UBA52 R-HSA-983168 |Antigen processing: Ubiquitination & Proteasome degradation |0.103450196529771 |-2.26866497503627|311 |54 |0.0357379219060225 |1511 |10287 |PSME3,UBE2C,PSMD1,ASB3,RNF123,SOCS1,PSMF1,PSMD3,ANAPC5,FBXL20,TRIP12,RNF114,HECW2,SPSB2,ASB13,PSMD14,RBCK1,FBXO7,PSMA6,CDC34,PSMD7,PSMD12,UBE3D,FBXO22,ITCH,KLHL11,UBE2J2,FBXL19,PSMD9,PSMC5,LRSAM1,RNF130,HERC3,HECTD1,CUL7,ASB6,PSMB11,KEAP1,RBBP6,RNF41,FBXO15,FBXO31,PSMB3,TRIM39,MIB2,UBA52,PSMB10,ZNRF1,LNPEP,UBE3C,UBE2O,RPS27A,ASB1,ANAPC11 R-HSA-187037 |NGF signalling via TRKA from the plasma membrane |0.104114055093148 |-2.26226829717095|387 |66 |0.0436796823295831 |1511 |10287 |ARRB1,PSMB3,GRB2,MAPKAPK3,SHC2,AGO1,DUSP3,PRKAR1A,UBA52,LAMTOR2,PRKCD,PSMD9,SOS1,MAPKAP1,ITPR3,PSMD7,WDR83,RALB,TRIB3,FGF17,PSMD14,PDGFB,CLTC,FN1,PIK3R1,CREB1,SPTBN1,DNM2,MAPK14,PSMF1,PSMD3,RALGDS,AKAP9,ADCY4,KSR1,TNRC6A,RPS27A,CD28,GSK3B,PSMB10,MOV10,PSMC5,PRKAR2A,SRC,SPTBN2,ERBB2,PSMB11,PTPRA,PSMA6,SPRED2,AP2M1,PSMD12,INSR,TNRC6C,PSMD1,PRKACA,ERBB3,FGFR3,GRIN2A,PSME3,PPP2CA,MAPKAPK2,RASGRF1,DUSP9,PIK3AP1,PRKCE R-HSA-4086400|PCP/CE pathway |0.104216410024639 |-2.2612856762214 |96 |19 |0.0125744540039709 |1511 |10287 |PSMF1,PSMD3,PSMB11,PSMD1,PSMD9,PSME3,PSMC5,RPS27A,PSMB10,UBA52,CLTC,AP2M1,PSMD12,PSMD7,PSMB3,PSMA6,FZD5,WNT11,PSMD14 R-HSA-927802 |Nonsense-Mediated Decay (NMD) |0.105665121891427 |-2.24748041320387|120 |23 |0.0152217074784911 |1511 |10287 |RPL18,UBA52,RPS28,RPL23,RPL9,RPS27A,RPL31,CASC3,RPS7,GSPT1,RPS21,RPL29,DCP1A,RPS6,RPS26,RPL27,EIF4A3,RPS14,PPP2CA,RPL37A,RPS16,RPS15A,RNPS1 R-HSA-975957 |Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |0.105665121891427 |-2.24748041320387|120 |23 |0.0152217074784911 |1511 |10287 |CASC3,GSPT1,RPS7,UBA52,RPL18,RPS28,RPS27A,RPL31,RPL23,RPL9,EIF4A3,RPS14,PPP2CA,RPS6,RPL27,RPS26,RNPS1,RPL37A,RPS16,RPS15A,RPS21,DCP1A,RPL29 R-HSA-73887 |Death Receptor Signalling |0.106758986373307 |-2.2371814489335 |50 |11 |0.00727994705493051 |1511 |10287 |USP4,UBA52,OTUD7B,OTULIN,RIPK1,NSMAF,CFLAR,RPS27A,RNF31,RBCK1,CASP10 R-HSA-69481 |G2/M Checkpoints |0.108884146960282 |-2.21747083392593|169 |31 |0.0205162144275314 |1511 |10287 |SFN,UIMC1,HUS1,RPS27A,UBA52,NSD2,PSMB10,PSMD12,TOPBP1,PSMD7,PSMB3,TOP3A,WEE1,PSMA6,ORC2,PSMD14,HIST1H4C,RNF8,HIST1H2BN,PSMD3,PSMF1,BRIP1,RMI2,PSMB11,YWHAG,PSMD1,NBN,PSMD9,PSME3,HIST1H2BI,PSMC5 R-HSA-6781827|Transcription-Coupled Nucleotide Excision Repair (TC-NER) |0.109756501272891 |-2.20949099167068|79 |16 |0.0105890138980807 |1511 |10287 |COPS8,USP7,POLR2D,POLE2,XPA,RFC1,GTF2H1,COPS6,MIR1281,GTF2H5,UBA52,RPS27A,GPS1,COPS7B,POLR2A,ELL R-HSA-381038 |XBP1(S) activates chaperone genes |0.110749210070634 |-2.2004870026274 |56 |12 |0.00794176042356056 |1511 |10287 |ACADVL,WFS1,SRPRA,GOSR2,ATP6V0D1,GFPT1,SEC61B,CUL7,PDIA5,LMNA,HYOU1,SEC63 R-HSA-5696399|Global Genome Nucleotide Excision Repair (GG-NER) |0.111040512798424 |-2.19786016409288|85 |17 |0.0112508272667108 |1511 |10287 |TFPT,COPS7B,USP45,RPS27A,GPS1,GTF2H5,UBA52,RAD23B,COPS6,RUVBL1,RFC1,GTF2H1,UBE2I,INO80D,XPA,COPS8,POLE2 R-HSA-5663202|Diseases of signal transduction |0.112666112590852 |-2.18332659001199|370 |63 |0.0416942422236929 |1511 |10287 |PAPSS1,PSMB10,UBA52,MIB2,CD28,GSK3B,STAT5A,RPS27A,CTBP1,KSR1,GRB2,AKAP9,PSMB3,HDAC10,CTNNB1,ARRB1,MYO18A,JAG1,TRIM24,LRP6,TCF7L2,PSMB11,ERBB2,MAPKAP1,LMNA,SRC,SOS1,PSMC5,PSMD9,PSEN2,STAT5B,PSMD12,STAT1,MIR1281,HDAC2,ERLEC1,PDGFB,PSMD14,FGF17,RNF43,FZD5,NCOR2,PSMA6,LRP5,POLR2A,PSMD7,POLR2D,PIK3AP1,PSMD3,PSMF1,MPRIP,PSME3,PPP2CA,CUX1,FGFR3,LRRFIP1,ERBB3,SHH,PSMD1,CREB1,TGFBR2,PIK3R1,FN1 R-HSA-1799339|SRP-dependent cotranslational protein targeting to membrane |0.113326269351985 |-2.17748428122978|115 |22 |0.014559894109861 |1511 |10287 |RPS26,RPL27,RPS6,SRPRA,RPS14,RPS16,RPS15A,RPL37A,RPS21,SRP68,RPL29,RPN1,RPS7,RPS28,UBA52,RPL18,SEC61B,RPL23,RPL9,RPL31,SRP9,RPS27A R-HSA-72649 |Translation initiation complex formation |0.113858693096577 |-2.17279713368618|62 |13 |0.0086035737921906 |1511 |10287 |RPS21,RPS28,RPS27A,EIF2S2,RPS14,RPS6,EIF3G,RPS26,EIF3D,RPS7,EIF4E,RPS15A,RPS16 R-HSA-5688426|Deubiquitination |0.115596080660479 |-2.15765322763974|301 |52 |0.0344142951687624 |1511 |10287 |INO80D,HIST1H2BN,USP25,USP7,USP4,PSMB11,KEAP1,ASXL1,PSMD9,PSMC5,ADRM1,USP15,RPS27A,FOXK1,UIMC1,CCP110,OTUD7B,PSMB10,UBA52,NFKBIA,PSMB3,USP47,ARRB1,AXIN2,STAM2,PSMF1,RNF146,PSMD3,RIPK1,USP37,PSMD1,RNF123,RUVBL1,USP33,TGFBR2,PSME3,HIST1H2BI,MDM4,USP42,TRIM25,RAD23B,USP19,PSMD12,MIR1281,SMAD7,MBD6,FOXK2,PSMD7,TFPT,VDAC2,PSMD14,PSMA6 R-HSA-72312 |rRNA processing |0.116204915622366 |-2.15240013234061|201 |36 |0.0238252812706817 |1511 |10287 |NOL11,RPS7,TFB1M,RIOK1,KRR1,RPL23,DIMT1,RPL18,RPS16,CSNK1D,RPS26,TBL3,RPL29,RPS21,THUMPD1,MPHOSPH10,SENP3,RPL9,RPL31,RPS27A,RPS28,UBA52,LTV1,RPS15A,RPL37A,NOL9,RPL27,RPS6,RPS14,XRN2,MIR1292,NOP14,UTP18,EXOSC6,PRORP,WDR18 R-HSA-948021 |Transport to the Golgi and subsequent modification |0.116236993122606 |-2.15212412789187|164 |30 |0.0198544010589014 |1511 |10287 |MCFD2,SCFD1,SPTBN2,TRAPPC2L,COPG1,COPB2,B4GALT3,TGFA,COG7,B4GALT2,GOSR2,SPTBN1,CSNK1D,TRAPPC5,MGAT5,TRAPPC6B,CTSZ,MIA2,MGAT4A,ARF3,ARFGAP3,DYNLL2,LMAN1L,MAN1A1,MGAT1,COG1,B4GALT4,FUCA1,B4GALT5,COG2 R-HSA-5668541|TNFR2 non-canonical NF-kB pathway |0.121648888704477 |-2.10661634498154|104 |20 |0.0132362673726009 |1511 |10287 |PSMB3,PSMD7,LTBR,PSMD14,PSMA6,LTB,RPS27A,TNFRSF12A,TNFRSF14,PSMD12,TNFRSF6B,PSMB10,UBA52,PSMD1,PSMD9,PSMC5,PSME3,PSMD3,PSMF1,PSMB11 R-HSA-429914 |Deadenylation-dependent mRNA decay |0.122535431716213 |-2.09935505231904|57 |12 |0.00794176042356056 |1511 |10287 |LSM2,DCP1A,CNOT11,EXOSC6,LSM5,WDR61,DCP1B,EDC4,EIF4E,LSM4,SKIV2L,EIF4A3 R-HSA-72662 |Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |0.125207890795685 |-2.07777979677752|63 |13 |0.0086035737921906 |1511 |10287 |EIF2S2,RPS27A,RPS28,RPS21,RPS16,RPS15A,EIF4E,RPS7,EIF3D,RPS26,EIF3G,RPS6,RPS14 R-HSA-73894 |DNA Repair |0.127365574496654 |-2.0606937882408 |316 |54 |0.0357379219060225 |1511 |10287 |GTF2H5,UBA52,DCLRE1C,RPS27A,UIMC1,HIST1H4C,ALKBH3,REV1,PPP4C,ELL,POLE2,USP7,ASCC1,HIST1H2BN,INO80D,RAD52,NBN,UBE2I,KDM4A,RFC1,COPS6,FANCE,XRCC5,RAD23B,RAD51C,NSD2,MIR1281,GPS1,HUS1,PNKP,ZBTB32,TRIM25,USP45,COPS7B,POLM,RIF1,POLR2A,TOP3A,TFPT,TOPBP1,RAD18,POLR2D,BRIP1,COPS8,RMI2,RNF8,FANCF,XPA,HIST1H2BI,PALB2,CENPX,GTF2H1,RUVBL1,FANCA R-HSA-5654738|Signaling by FGFR2 |0.128650530945199 |-2.05065561321122|75 |15 |0.0099272005294507 |1511 |10287 |POLR2D,UBA52,HNRNPF,RPS27A,ESRP2,RBFOX2,SRC,SOS1,PPP2CA,FGF17,GRB2,HNRNPH1,POLR2A,PIK3R1,SPRY2 R-HSA-8854518|AURKA Activation by TPX2 |0.128650530945199 |-2.05065561321122|75 |15 |0.0099272005294507 |1511 |10287 |HAUS4,CEP250,CCP110,CEP63,CKAP5,AKAP9,TUBA4A,HAUS8,PCM1,ALMS1,YWHAG,CSNK1D,NINL,AURKA,PRKACA R-HSA-72706 |GTP hydrolysis and joining of the 60S ribosomal subunit |0.129869003226748 |-2.04122900405131|117 |22 |0.014559894109861 |1511 |10287 |RPS7,EIF4E,EIF3G,RPS27A,RPL31,RPL23,RPL9,EIF2S2,RPL18,UBA52,RPS28,EIF3D,RPL37A,RPS16,RPS15A,RPS14,RPS6,RPS26,RPL27,EIF5B,RPL29,RPS21 R-HSA-5368286|Mitochondrial translation initiation |0.130296978925333 |-2.03793898065095|87 |17 |0.0112508272667108 |1511 |10287 |GADD45GIP1,MRPL27,MRPL58,MRPS9,MRPS18A,MRPS5,MRPL33,MRPL53,MRPL19,MRPS26,MRPL17,MTIF2,MRPS35,MRPL12,MRPL18,MRPL44,MRPS23 R-HSA-8868773|rRNA processing in the nucleus and cytosol |0.131628436774457 |-2.02777219852161|191 |34 |0.0225016545334216 |1511 |10287 |CSNK1D,RPS16,RPS26,RPL29,TBL3,RPS21,NOL11,RPS7,KRR1,RIOK1,RPL23,DIMT1,RPL18,NOL9,RPS15A,RPL37A,RPS14,RPL27,RPS6,NOP14,MIR1292,XRN2,EXOSC6,UTP18,WDR18,MPHOSPH10,THUMPD1,SENP3,RPL31,RPS27A,RPL9,LTV1,RPS28,UBA52 R-HSA-2980766|Nuclear Envelope Breakdown |0.132013358484387 |-2.02485216087691|52 |11 |0.00727994705493051 |1511 |10287 |LEMD2,RAE1,NDC1,NEK9,LMNA,LMNB1,NUP42,NUP210,AAAS,LPIN3,NUP54 R-HSA-4839726|Chromatin organization |0.132644784806171 |-2.02008051461664|279 |48 |0.0317670416942422 |1511 |10287 |KMT2D,SMYD2,HIST1H4C,MTA3,HDAC10,SUPT3H,KDM2B,ARID5B,SGF29,SMARCD2,MRGBP,KDM4A,CDK4,KDM5B,HAT1,ATF2,PRMT3,DNMT3A,KANSL3,SMARCE1,COPRS,ARID1A,JADE2,HIST1H2BN,NCOR2,GATAD2A,RELA,ELP1,KDM3B,ATXN7L3,NSD2,RCOR1,MIR1281,HDAC2,SETD1A,HIST1H2BI,PRMT7,KDM8,RUVBL1,KDM4C,PHF20,PRMT1,SUV39H1,KAT7,PRMT5,CARM1,SETD6,ING5 R-HSA-3247509|Chromatin modifying enzymes |0.132644784806171 |-2.02008051461664|279 |48 |0.0317670416942422 |1511 |10287 |SMARCD2,MRGBP,KDM4A,PRMT3,ATF2,HAT1,CDK4,KDM5B,JADE2,DNMT3A,KANSL3,ARID1A,SMARCE1,COPRS,HIST1H2BN,MTA3,KMT2D,SMYD2,HIST1H4C,HDAC10,SUPT3H,SGF29,KDM2B,ARID5B,PRMT7,SETD1A,HIST1H2BI,KDM4C,KDM8,RUVBL1,PHF20,PRMT1,SUV39H1,CARM1,SETD6,ING5,KAT7,PRMT5,GATAD2A,NCOR2,ATXN7L3,ELP1,RELA,KDM3B,NSD2,MIR1281,RCOR1,HDAC2 R-HSA-6791226|Major pathway of rRNA processing in the nucleolus and cytosol |0.134560134993045 |-2.00574407953977|179 |32 |0.0211780277961615 |1511 |10287 |RPL18,RPL23,KRR1,RIOK1,RPS7,NOL11,RPS21,RPL29,TBL3,RPS26,CSNK1D,RPS16,LTV1,UBA52,RPS28,RPS27A,RPL31,RPL9,SENP3,MPHOSPH10,WDR18,EXOSC6,UTP18,NOP14,MIR1292,XRN2,RPS14,RPS6,RPL27,NOL9,RPL37A,RPS15A R-HSA-68882 |Mitotic Anaphase |0.134560134993045 |-2.00574407953977|179 |32 |0.0211780277961615 |1511 |10287 |SGO2,PSMD3,ANAPC5,PSMF1,PSME3,PPP2CA,UBE2C,PSMD1,PSMD12,CENPU,CENPM,NDEL1,PSMD14,PSMA6,STAG2,PSMD7,LEMD2,PSMB11,LMNA,CLASP2,PSMD9,PSMC5,CKAP5,PSMB10,UBA52,RPS27A,BIRC5,ANAPC11,LMNB1,PSMB3,WAPL,XPO1 R-HSA-2424491|DAP12 signaling |0.136596567641106 |-1.99072345923942|356 |60 |0.0397088021178028 |1511 |10287 |FGF17,PSMD14,TRIB3,PSMA6,PSMD7,WDR83,PTPRA,PSMD12,PDGFB,SPRED2,PPP2CA,PSME3,GRIN2A,PSMD1,PRKACA,ERBB3,FGFR3,FN1,PIK3R1,SPTBN1,INSR,CREB1,TNRC6C,PRKCE,VAV3,DUSP9,PIK3AP1,PSMF1,RASGRF1,PSMD3,ADCY4,AKAP9,GRB2,PSMB3,ARRB1,LAMTOR2,CD28,GSK3B,PRKAR1A,UBA52,PSMB10,KSR1,TNRC6A,RPS27A,SHC2,AGO1,PSMC5,PSMD9,HLA-E,PRKCD,VAV2,MOV10,PSMB11,ITPR3,SPTBN2,MAPKAP1,ERBB2,PRKAR2A,SOS1,SRC R-HSA-450294 |MAP kinase activation in TLR cascade |0.137173364663673 |-1.98650971764144|64 |13 |0.0086035737921906 |1511 |10287 |MAPKAPK3,PPP2CA,MAPK9,JUN,CREB1,ATF2,MAP2K7,UBA52,DUSP3,MAPKAPK2,RPS27A,IRAK2,MAPK14 R-HSA-425366 |Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |0.13994582905639 |-1.96649986656312|106 |20 |0.0132362673726009 |1511 |10287 |SLC6A12,RHCG,SLC30A2,SLC22A7,SLC6A11,SLC44A4,SLC22A1,SLC13A5,SLC16A3,CP,SLC44A1,SLC6A2,SLC47A1,SLC2A11,MIR6787,SLC5A2,SLC13A3,SLC39A4,SLC2A6,SLC22A16 R-HSA-380270 |Recruitment of mitotic centrosome proteins and complexes |0.140334486698043 |-1.96372651525074|82 |16 |0.0105890138980807 |1511 |10287 |TUBGCP6,CCP110,HAUS8,PCM1,CEP63,AKAP9,TUBA4A,ALMS1,TUBGCP3,HAUS4,CEP250,CKAP5,NINL,CSNK1D,PRKACA,YWHAG R-HSA-380287 |Centrosome maturation |0.140334486698043 |-1.96372651525074|82 |16 |0.0105890138980807 |1511 |10287 |TUBGCP3,HAUS4,CEP250,CKAP5,NINL,CSNK1D,PRKACA,YWHAG,TUBGCP6,CCP110,HAUS8,PCM1,CEP63,AKAP9,TUBA4A,ALMS1 R-HSA-5620912|Anchoring of the basal body to the plasma membrane |0.140368359209782 |-1.96348517454189|100 |19 |0.0125744540039709 |1511 |10287 |YWHAG,CSNK1D,NINL,PRKACA,CKAP5,MKS1,NPHP4,HAUS4,CEP83,CEP250,ALMS1,RAB3IP,CEP63,TUBA4A,AKAP9,HAUS8,PCM1,CCP110,TCTN1 R-HSA-194840 |Rho GTPase cycle |0.14297817610685 |-1.94506327500644|143 |26 |0.0172071475843812 |1511 |10287 |RHOF,ARHGAP23,GNA13,PLEKHG2,MCF2L,ARAP1,ARHGEF1,RHOC,PREX1,NGEF,ARHGAP5,RALBP1,SOS1,ARHGDIA,RHOB,MIR7706,ARHGAP26,ARHGAP29,VAV3,TRIP10,SRGAP1,ARHGEF40,VAV2,ARHGAP27,ARHGEF3,FGD2 R-HSA-168273 |Influenza Viral RNA Transcription and Replication |0.144268765161084 |-1.9360772942828 |137 |25 |0.0165453342157512 |1511 |10287 |RPS7,NUP54,POLR2A,NUP42,AAAS,RPL23,NDC1,RPL9,RPL31,RPS27A,RPS28,UBA52,RPL18,RPS15A,RPS16,RPL37A,RPL27,RPS26,RPS6,NUP210,RPS14,RPL29,RPS21,RAE1,POLR2D R-HSA-75153 |Apoptotic execution phase |0.145754599534271 |-1.92583089655292|53 |11 |0.00727994705493051 |1511 |10287 |PRKCD,CTNNB1,GSN,HIST1H1A,DNM1L,ACIN1,LMNA,DSP,LMNB1,KPNB1,HIST1H1E R-HSA-190236 |Signaling by FGFR |0.151360179238815 |-1.88809298949048|89 |17 |0.0112508272667108 |1511 |10287 |HNRNPF,POLR2D,SRC,SOS1,ESRP2,PPP2CA,PIK3R1,FGFR3,HNRNPH1,UBA52,SPRED2,RPS27A,RBFOX2,GRB2,FGF17,SPRY2,POLR2A R-HSA-5621481|C-type lectin receptors (CLRs) |0.151383744240606 |-1.88793731335622|144 |26 |0.0172071475843812 |1511 |10287 |PSMB3,CDC34,RELA,NFKBIA,NFATC2,PSMD7,PSMD14,PSMA6,RPS27A,PSMD12,PSMB10,UBA52,MIR1281,PSMD1,PRKACA,PSMC5,PSMD9,PSME3,PRKCD,PSMD3,PSMF1,SRC,CARD9,NFATC3,ITPR3,PSMB11 R-HSA-69620 |Cell Cycle Checkpoints |0.158150049076527 |-1.8442110189142 |201 |35 |0.0231634679020516 |1511 |10287 |YWHAG,PSMD1,MDM4,UBE2C,PSME3,HIST1H2BI,RNF8,PSMF1,PSMD3,ANAPC5,RMI2,BRIP1,PSMD7,TOPBP1,TOP3A,ORC2,PSMA6,WEE1,PSMD14,SFN,HUS1,NSD2,PSMD12,PSMC5,PSMD9,NBN,HIST1H2BN,PSMB11,PSMB3,HIST1H4C,ANAPC11,UIMC1,RPS27A,UBA52,PSMB10 R-HSA-983169 |Class I MHC mediated antigen processing & presentation |0.158541098512484 |-1.84174142266763|373 |62 |0.0410324288550629 |1511 |10287 |PSMD14,RBCK1,SPSB2,ASB13,FBXO7,PSMA6,CDC34,HSPA5,PSMD7,PSMD12,UBE3D,SEC61B,STX4,FBXO22,ITCH,FBXL19,UBE2J2,CYBA,KLHL11,PSME3,UBE2C,RNF123,PSMD1,ASB3,SOCS1,SNAP23,FBXL20,ANAPC5,PSMD3,PSMF1,RNF114,HECW2,TRIP12,FBXO31,FBXO15,PSMB3,CALR,TRIM39,PSMB10,UBA52,MIB2,ASB1,RPS27A,UBE3C,LNPEP,UBE2O,ZNRF1,ANAPC11,LRSAM1,HLA-E,PSMD9,PSMC5,RNF130,ITGB5,HERC3,CUL7,HECTD1,KEAP1,PSMB11,ASB6,RBBP6,RNF41 R-HSA-5683057|MAPK family signaling cascades |0.160071093516209 |-1.83213722795934|290 |49 |0.0324288550628723 |1511 |10287 |LAMTOR2,PSMB10,UBA52,TNRC6A,KSR1,RPS27A,SHC2,AGO1,NCOA3,AKAP9,GRB2,PSMB3,ARRB1,XPO1,IGF2BP1,PSMB11,ERBB2,SPTBN2,SOS1,SRC,PSMC5,PSMD9,JUN,MOV10,PSMD12,SPRED2,PDGFB,FGF17,PSMD14,PSMA6,HSPB1,WDR83,PSMD7,PTPRA,DUSP9,PSMF1,ETV4,RASGRF1,PSMD3,PSME3,PPP2CA,GRIN2A,ERBB3,PSMD1,PRKACA,FGFR3,FN1,TNRC6C,SPTBN1 R-HSA-74752 |Signaling by Insulin receptor |0.160371349765584 |-1.83026321692526|322 |54 |0.0357379219060225 |1511 |10287 |PTPRA,EIF4E,WDR83,PSMD7,PSMD14,FGF17,ATP6V1G1,PSMA6,TRIB3,PDGFB,SPRED2,PSMD12,FGFR3,PSMD1,ERBB3,INSR,SPTBN1,FN1,PIK3R1,PPP2CA,PSME3,GRIN2A,PSMD3,RASGRF1,PSMF1,EEF2K,DUSP9,TCIRG1,PSMB3,ATP6V1B2,ATP6V1E2,ATP6V0D1,STRADA,ARRB1,LAMTOR5,ATP6V0C,GRB2,AKAP9,ATP6V1F,RPS27A,KSR1,SHC2,LAMTOR2,PSMB10,UBA52,PDE3B,PSMD9,PSMC5,RPS6,SPTBN2,ERBB2,SRC,SOS1,PSMB11 R-HSA-156842 |Eukaryotic Translation Elongation |0.161775502937192 |-1.8215456891752 |96 |18 |0.0119126406353408 |1511 |10287 |RPS7,RPS28,UBA52,RPL18,RPL31,EEF1B2,RPS27A,RPL9,RPL23,RPS14,RPS26,RPL27,RPS6,RPS16,RPS15A,RPL37A,RPS21,RPL29 R-HSA-428157 |Sphingolipid metabolism |0.162550667447824 |-1.81676552613285|90 |17 |0.0112508272667108 |1511 |10287 |SPTSSB,CERK,SPHK1,PRKD3,SMPD4,DEGS2,SPHK2,SMPD1,CERS2,CSNK1G2,SPTSSA,ALDH3B1,CERS4,ENPP7,SUMF1,ORMDL3,ESYT1 R-HSA-975871 |MyD88 cascade initiated on plasma membrane |0.16311024472469 |-1.81332895879138|84 |16 |0.0105890138980807 |1511 |10287 |MAPK14,MAPKAPK2,JUN,PPP2CA,ATF2,CREB1,DUSP3,UBA52,IRAK2,RPS27A,MAPK9,MAPKAPK3,NFKBIB,MAP2K7,NFKBIA,RELA R-HSA-168142 |Toll Like Receptor 10 (TLR10) Cascade |0.16311024472469 |-1.81332895879138|84 |16 |0.0105890138980807 |1511 |10287 |MAP2K7,NFKBIB,NFKBIA,RELA,MAPK9,MAPKAPK3,IRAK2,RPS27A,DUSP3,UBA52,ATF2,CREB1,JUN,PPP2CA,MAPK14,MAPKAPK2 R-HSA-168176 |Toll Like Receptor 5 (TLR5) Cascade |0.16311024472469 |-1.81332895879138|84 |16 |0.0105890138980807 |1511 |10287 |MAPKAPK3,MAPK9,NFKBIB,MAP2K7,RELA,NFKBIA,UBA52,DUSP3,RPS27A,IRAK2,JUN,PPP2CA,CREB1,ATF2,MAPK14,MAPKAPK2 R-HSA-380284 |Loss of proteins required for interphase microtubule organization from the centrosome |0.163360474393268 |-1.81179602059553|72 |14 |0.00926538716082065 |1511 |10287 |CCP110,HAUS4,CEP250,NINL,CSNK1D,PRKACA,ALMS1,YWHAG,HAUS8,PCM1,CEP63,CKAP5,TUBA4A,AKAP9 R-HSA-380259 |Loss of Nlp from mitotic centrosomes |0.163360474393268 |-1.81179602059553|72 |14 |0.00926538716082065 |1511 |10287 |HAUS8,PCM1,CEP63,CKAP5,TUBA4A,AKAP9,NINL,CSNK1D,PRKACA,ALMS1,YWHAG,HAUS4,CEP250,CCP110 R-HSA-1433557|Signaling by SCF-KIT |0.173310925471345 |-1.75266804055851|337 |56 |0.0370615486432826 |1511 |10287 |AKAP9,GRB2,PSMB3,ARRB1,LAMTOR2,STAT5A,GSK3B,CD28,UBA52,PSMB10,TNRC6A,KSR1,RPS27A,GRB7,SHC2,AGO1,PSMC5,PSMD9,STAT5B,MOV10,PSMB11,MAPKAP1,SPTBN2,ERBB2,SOS1,SRC,FGF17,PSMD14,TRIB3,PSMA6,MMP9,PSMD7,WDR83,PTPRA,STAT1,PSMD12,SPRED2,PDGFB,PSME3,PPP2CA,GRIN2A,ERBB3,PSMD1,FGFR3,PIK3R1,FN1,INSR,SOCS1,CREB1,SPTBN1,TNRC6C,DUSP9,PIK3AP1,PSMF1,RASGRF1,PSMD3 R-HSA-1643685|Disease |0.173545495005253 |-1.75131549491818|859 |136 |0.0900066181336863 |1511 |10287 |GTF2H5,UBA52,MIB2,STAT5A,RPL9,VPS4A,RPL31,GRB2,STAM2,NPM1,ARRB1,XPO1,CALR,JAG1,ELL,LRP6,TRIM24,TAF4,RPS14,CHMP6,STAT5B,CLTC,SDC1,PDGFB,FZD5,RNF43,IDH1,RPS7,PSMD7,NUP54,RPL29,GTF2H1,KPNA4,CCNT1,CREB1,PIK3R1,STX1B,PSMB10,GSK3B,LMNB1,CTBP1,AAAS,CTNNB1,HMGA1,ERBB2,JUN,FDX2,MMUT,PSMC5,RPL37A,ERLEC1,NDC1,KPNB1,PSMA6,SUPT5H,PPP1R3C,THBS1,GTF2A2,MAP2K7,MCCC2,LRP5,FURIN,PIK3AP1,CDC25B,POLR2D,CHMP4A,NUP210,PSME3,TGFBR2,FGFR3,ERBB3,SHH,LRRFIP1,DERL1,RPS28,THBS2,GTF2E2,PAPSS1,CHMP3,CHMP4B,PSMB3,HDAC10,NFKBIA,TCF7L2,RAE1,LMNA,SOS1,MAPKAP1,PSMD9,RPS15A,PSEN2,XRCC5,STAT1,FDXR,PSMD14,FGF17,RELA,POLR2A,PDCD6IP,PSMD3,HCK,PSMF1,MPRIP,AP1S3,RPS26,FN1,CD28,RPS27A,KSR1,PPIA,HSP90AB1,AKAP9,NUP42,MYO18A,NFKBIB,SOD2,PSMB11,SRC,RPS6,RPL27,SH3GL1,SDC4,RPL18,MIR1281,PSMD12,AP2M1,RPL23,KPNA5,HDAC2,TBP,NCOR2,RPS21,CUX1,PPP2CA,RPS16,PSMD1 R-HSA-8848021|Signaling by PTK6 |0.17662027450048 |-1.73375319275585|67 |13 |0.0086035737921906 |1511 |10287 |CDK4,BCAR1,ARAP1,ERBB3,ELMO2,DOK1,RPS27A,EPAS1,ERBB2,PTK6,SPRED2,PTPN1,UBA52 R-HSA-196849 |Metabolism of water-soluble vitamins and cofactors |0.177104330624672 |-1.73101628150151|122 |22 |0.014559894109861 |1511 |10287 |QPRT,PARP16,MOCS3,SLC19A1,NADK,FASN,MTHFD2,ALDH1L1,SLC25A19,MCCC2,NAXD,MTHFS,PANK3,MTHFD1L,NAMPT,MMUT,THTPA,SLC23A2,RFK,NFS1,PNPO,PANK2 R-HSA-2172127|DAP12 interactions |0.183908896501269 |-1.69331477169985|371 |61 |0.0403706154864328 |1511 |10287 |SHC2,AGO1,TNRC6A,KSR1,RPS27A,PRKAR1A,CD28,GSK3B,UBA52,PSMB10,LAMTOR2,ARRB1,PSMB3,AKAP9,GRB2,ADCY4,PRKAR2A,SOS1,SRC,MAPKAP1,SPTBN2,ERBB2,PSMB11,ITPR3,MOV10,VAV2,PRKCD,SIGLEC16,PSMC5,PSMD9,HLA-E,SPRED2,PDGFB,PSMD12,PSMD7,WDR83,PTPRA,TRIB3,PSMA6,FGF17,PSMD14,PSMF1,RASGRF1,PSMD3,DUSP9,PIK3AP1,VAV3,PRKCE,PIK3R1,FN1,CREB1,SPTBN1,INSR,TNRC6C,PRKACA,PSMD1,ERBB3,FGFR3,GRIN2A,PSME3,PPP2CA R-HSA-156902 |Peptide chain elongation |0.18619555765325 |-1.68095777235476|92 |17 |0.0112508272667108 |1511 |10287 |RPS7,RPS28,UBA52,RPL18,RPL9,RPL23,RPL31,RPS27A,RPL27,RPS26,RPS6,RPS14,RPS15A,RPS16,RPL37A,RPS21,RPL29 R-HSA-611105 |Respiratory electron transport |0.18619555765325 |-1.68095777235476|92 |17 |0.0112508272667108 |1511 |10287 |NDUFS6,SCO1,NDUFV2,CYCS,ETFA,COQ10B,COX4I1,NDUFB2,NDUFA7,UQCRC2,COX5B,NDUFS7,NDUFAF5,NDUFB9,NDUFAF6,NDUFS5,NDUFAB1 R-HSA-192823 |Viral mRNA Translation |0.18619555765325 |-1.68095777235476|92 |17 |0.0112508272667108 |1511 |10287 |RPS14,RPL27,RPS26,RPS6,RPS15A,RPS16,RPL37A,RPS21,RPL29,RPS7,RPS28,UBA52,RPL18,RPL31,RPS27A,RPL23,RPL9 R-HSA-167044 |Signalling to RAS |0.18926108889854 |-1.66462779446547|256 |43 |0.028457974851092 |1511 |10287 |RALB,PSMD7,WDR83,PTPRA,PSMA6,FGF17,PSMD14,SPRED2,PDGFB,PSMD12,FN1,SPTBN1,PSMD1,ERBB3,FGFR3,GRIN2A,PSME3,PPP2CA,MAPK14,PSMF1,MAPKAPK2,PSMD3,RASGRF1,DUSP9,RALGDS,ARRB1,PSMB3,AKAP9,GRB2,MAPKAPK3,SHC2,KSR1,RPS27A,UBA52,PSMB10,LAMTOR2,PSMC5,PSMD9,SOS1,SRC,SPTBN2,ERBB2,PSMB11 R-HSA-156827 |L13a-mediated translational silencing of Ceruloplasmin expression |0.189817391281678 |-1.66169276749046|117 |21 |0.013898080741231 |1511 |10287 |RPL29,RPS21,RPS16,RPS15A,RPL37A,EIF3D,RPL27,RPS26,RPS6,RPS14,EIF2S2,RPL9,RPL23,RPL31,RPS27A,RPS28,UBA52,RPL18,EIF4E,RPS7,EIF3G R-HSA-2454202|Fc epsilon receptor (FCERI) signaling |0.189939489934982 |-1.66104973157168|372 |61 |0.0403706154864328 |1511 |10287 |SPTBN2,MAPKAP1,ERBB2,SRC,SOS1,ITPR3,PSMB11,MOV10,VAV2,PSMC5,PSMD9,JUN,RPS27A,TNRC6A,KSR1,AGO1,SHC2,LAMTOR2,PSMB10,UBA52,CD28,GSK3B,PSMB3,NFKBIA,ARRB1,NFATC2,GRB2,AKAP9,RASGRF1,PSMD3,PSMF1,NFATC3,VAV3,PIK3AP1,DUSP9,FGFR3,PSMD1,ERBB3,SPTBN1,INSR,TNRC6C,CREB1,FN1,PIK3R1,PSME3,PPP2CA,GRIN2A,SPRED2,PDGFB,PSMD12,RELA,CDC34,PTPRA,WDR83,PSMD7,MAP2K7,PSMD14,MAPK9,FGF17,PSMA6,TRIB3 R-HSA-6790901|rRNA modification in the nucleus and cytosol |0.191274000965891 |-1.65404831890287|62 |12 |0.00794176042356056 |1511 |10287 |KRR1,RPS14,RPS6,MPHOSPH10,NOL11,RPS7,THUMPD1,UTP18,DIMT1,NOP14,MIR1292,TBL3 R-HSA-202733 |Cell surface interactions at the vascular wall |0.192945530705898 |-1.6453473542318 |136 |24 |0.0158835208471211 |1511 |10287 |ITGB2,EPCAM,SDC1,GRB7,GRB2,PPIA,INPP5D,SLC7A10,GLG1,SLC16A3,F11R,SLC7A7,PROC,CXADR,MIR6787,APOB,SOS1,SRC,SLC7A5,PIK3R1,FN1,SLC7A6,SDC4,ITGA6 R-HSA-72689 |Formation of a pool of free 40S subunits |0.194329771037834 |-1.63819871231939|105 |19 |0.0125744540039709 |1511 |10287 |RPL31,RPS27A,RPL9,RPL23,RPS28,RPL18,UBA52,RPS7,EIF3G,RPL29,RPS21,EIF3D,RPS15A,RPS16,RPL37A,RPS14,RPS26,RPL27,RPS6 R-HSA-196854 |Metabolism of vitamins and cofactors |0.195284650867825 |-1.63329703677473|174 |30 |0.0198544010589014 |1511 |10287 |APOC3,PANK3,APOA2,SDC1,MTHFD1L,LRP10,SLC19A1,MOCS3,NADK,QPRT,PARP16,ALDH1L1,SLC25A19,FASN,MTHFD2,MTHFS,MCCC2,NAXD,NFS1,RFK,SLC23A2,APOB,PNPO,UBIAD1,PANK2,MMUT,APOE,NAMPT,THTPA,SDC4 R-HSA-975956 |Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |0.196513393998083 |-1.62702468715569|99 |18 |0.0119126406353408 |1511 |10287 |GSPT1,RPS7,RPL18,UBA52,RPS28,RPS27A,RPL31,RPL9,RPL23,RPS14,RPS6,RPS26,RPL27,RPL37A,RPS15A,RPS16,RPS21,RPL29 R-HSA-2467813|Separation of Sister Chromatids |0.198246548744111 |-1.61824382722345|168 |29 |0.0191925876902713 |1511 |10287 |XPO1,STAG2,PSMD7,PSMB3,WAPL,PSMA6,PSMD14,NDEL1,CENPM,ANAPC11,RPS27A,BIRC5,CENPU,PSMB10,UBA52,PSMD12,PSMD1,CKAP5,UBE2C,CLASP2,PSMD9,PSME3,PSMC5,PPP2CA,ANAPC5,PSMD3,PSMF1,PSMB11,SGO2 R-HSA-5419276|Mitochondrial translation termination |0.200632649508979 |-1.60627965743106|87 |16 |0.0105890138980807 |1511 |10287 |MRPL18,MRPL12,MRPL44,MRPS23,MRPL17,MRPL53,MRPS26,MRPL19,MRPS35,MRPS18A,MRPS5,MRPL33,GADD45GIP1,MRPL58,MRPL27,MRPS9 R-HSA-168249 |Innate Immune System |0.204943632850452 |-1.58502029935774|1285 |199 |0.131700860357379 |1511 |10287 |SIGLEC16,JUN,PSMC5,TXN,RAB37,POLR3B,SERPINB6,COMMD3,PYGB,ATP11A,RBSN,APEH,C2,DEFB132,ERBB2,C1orf35,CAND1,ACTR1B,CTNNB1,FTH1,PSMB10,GSK3B,IST1,CTSB,ATP6V1F,GRIN2A,PSME3,INSR,TNRC6C,GSN,C5,C6orf120,CSTB,FGFR3,LRRFIP1,ERBB3,DGAT1,PIK3AP1,WASF2,DUSP9,APOB,RIPK1,KCMF1,NCKAP1,MAPKAPK2,RASGRF1,PSMA6,ATP6V1G1,GSDMD,SLPI,S100A1,MAP2K7,MMP9,S100P,ADGRG3,CTSZ,KPNB1,CSNK2B,ATG5,LBP,POLR1C,TMBIM1,VAV2,ATF2,ALDH3B1,ACTG1,JUP,IRF2,FUCA2,CARD9,GRB2,MAPKAPK3,ARRB1,ATP6V1E2,UBA52,PRKAR1A,LAMTOR2,POLR1D,CRCP,CREB1,PIK3R1,NME2,NFATC3,IRF1,ANPEP,SERPINB1,DYNLT1,FUCA1,BPIFB2,IDH1,MAPK9,PRCP,PSMD7,RNASET2,ITGB2,CD180,PDGFB,HLA-E,APRT,MOV10,PSMB11,STAT6,SRC,RNF125,PRKAR2A,BPIFB1,SPTBN2,PPIA,HSP90AB1,AKAP9,GAA,MYH9,CD68,ADCY4,NFKBIB,CASP10,ATP6V1B2,ATP6V0D1,CD28,PRDX6,RPS27A,IRAK2,KSR1,TNRC6A,PGM2,PPP2CA,SOCS1,TMC6,PRKACA,PSMD1,PRKCE,C3,ELMO2,CCT8,MYO1C,PTPRA,MANBA,WIPF2,MIR1281,PSMD12,CPPED1,SPRED2,TRIM25,PRKCD,PSMD9,CKAP4,TXNDC5,RAB10,PA2G4,ITPR3,SOS1,ACTR3,MAPKAP1,FRK,DPP7,ATP6V0C,NFATC2,PSMB3,NFKBIA,DUSP3,POLR3E,AGO1,RAB5B,RHOF,SHC2,LGALS3,STK10,PLD1,SPTBN1,FN1,CPNE1,FTL,VAT1,DNM2,SNAP23,TCIRG1,VAV3,MAPK14,DSP,UNC13D,PFKL,ORMDL3,PSMD3,HCK,PSMF1,TRIB3,PSMD14,FGF17,AHSG,BCL2L1,WDR83,RELA,BPIFB6,CDC34,NCKIPSD,ITCH,XRCC5,CYBA,TMEM30A R-HSA-6806834|Signaling by MET |0.20567047763441 |-1.58148001408958|69 |13 |0.0086035737921906 |1511 |10287 |ARF6,PIK3R1,SH3GL1,STAM2,GRB2,TNS4,RPS27A,SOS1,SRC,GGA3,PTPN1,LAMA5,UBA52 R-HSA-913531 |Interferon Signaling |0.209395557921899 |-1.56353019413317|201 |34 |0.0225016545334216 |1511 |10287 |STAT1,EGR1,KPNA5,KPNB1,TRIM25,NDC1,IP6K2,NUP54,FLNB,EIF4E,SAMHD1,CIITA,IRF1,IRF9,IFI30,NUP210,EIF4A3,KPNA4,TRIM2,MT2A,ISG20,SOCS1,UBA52,RPS27A,AAAS,NUP42,RAE1,PTPN1,TRIM8,IRF4,IRF2,HLA-E,PRKCD,EIF4E2 R-HSA-5368287|Mitochondrial translation |0.21143299526618 |-1.55384713794193|94 |17 |0.0112508272667108 |1511 |10287 |MRPL33,MRPS5,MRPS18A,MRPS9,MRPL58,MRPL27,GADD45GIP1,MRPS23,MRPL44,MRPL12,MRPL18,MTIF2,MRPS35,MRPL19,MRPS26,MRPL53,MRPL17 R-HSA-202403 |TCR signaling |0.212277813822901 |-1.54985941962974|119 |21 |0.013898080741231 |1511 |10287 |RPS27A,ZAP70,PSMD12,PSMB10,UBA52,PSMB3,RELA,CDC34,NFKBIA,PSMD7,PSMD14,INPP5D,PSMA6,PSMD3,PSMF1,PSMB11,PSMD1,PIK3R1,PSMD9,PSME3,PSMC5 R-HSA-5389840|Mitochondrial translation elongation |0.213971909037104 |-1.5419105387582 |88 |16 |0.0105890138980807 |1511 |10287 |MRPL58,MRPL27,GADD45GIP1,MRPS9,MRPS18A,MRPL33,MRPS5,MRPS26,MRPL19,MRPL53,MRPL17,MRPS35,MRPL12,MRPL18,MRPS23,MRPL44 R-HSA-5628897|TP53 Regulates Metabolic Genes |0.216428396606326 |-1.53049551785386|82 |15 |0.0099272005294507 |1511 |10287 |TXN,PRDX5,SCO1,COX5B,LAMTOR5,CYCS,YWHAG,MOV10,TNRC6C,LAMTOR2,COX4I1,TNRC6A,DDIT4,SFN,AGO1 R-HSA-75109 |Triglyceride Biosynthesis |0.216428396606326 |-1.53049551785386|82 |15 |0.0099272005294507 |1511 |10287 |MOGAT1,FASN,ACSL6,LPIN3,AGPAT3,DGAT1,PPT2,AGPAT1,ELOVL6,GPAT2,GPD1L,HACD3,ACBD6,ACSL5,MOGAT2 R-HSA-166016 |Toll Like Receptor 4 (TLR4) Cascade |0.220543134845599 |-1.51166198034436|126 |22 |0.014559894109861 |1511 |10287 |ATF2,CREB1,SOCS1,DNM2,JUN,LBP,PPP2CA,RIPK1,MAPK14,MAPKAPK2,MAP2K7,NFKBIB,NFKBIA,RELA,MAPK9,MAPKAPK3,IRAK2,RPS27A,DUSP3,ITGB2,UBA52,CD180 R-HSA-181438 |Toll Like Receptor 2 (TLR2) Cascade |0.224607956525712 |-1.49339881199042|95 |17 |0.0112508272667108 |1511 |10287 |MAPK9,MAPKAPK3,NFKBIB,MAP2K7,NFKBIA,RELA,DUSP3,UBA52,IRAK2,RPS27A,JUN,PPP2CA,ATF2,SOCS1,CREB1,MAPK14,MAPKAPK2 R-HSA-168188 |Toll Like Receptor TLR6:TLR2 Cascade |0.224607956525712 |-1.49339881199042|95 |17 |0.0112508272667108 |1511 |10287 |ATF2,SOCS1,CREB1,PPP2CA,JUN,MAPKAPK2,MAPK14,NFKBIA,RELA,NFKBIB,MAP2K7,MAPK9,MAPKAPK3,IRAK2,RPS27A,DUSP3,UBA52 R-HSA-168179 |Toll Like Receptor TLR1:TLR2 Cascade |0.224607956525712 |-1.49339881199042|95 |17 |0.0112508272667108 |1511 |10287 |DUSP3,UBA52,IRAK2,RPS27A,MAPK9,MAPKAPK3,MAP2K7,NFKBIB,NFKBIA,RELA,MAPK14,MAPKAPK2,JUN,PPP2CA,ATF2,CREB1,SOCS1 R-HSA-2408557|Selenocysteine synthesis |0.224607956525712 |-1.49339881199042|95 |17 |0.0112508272667108 |1511 |10287 |RPL18,UBA52,RPS28,RPS27A,RPL31,RPL23,RPL9,RPS7,RPS21,RPL29,RPS14,RPS6,RPL27,RPS26,RPL37A,RPS16,RPS15A R-HSA-166058 |MyD88:Mal cascade initiated on plasma membrane |0.224607956525712 |-1.49339881199042|95 |17 |0.0112508272667108 |1511 |10287 |RELA,NFKBIA,MAP2K7,NFKBIB,MAPKAPK3,MAPK9,RPS27A,IRAK2,UBA52,DUSP3,CREB1,SOCS1,ATF2,PPP2CA,JUN,MAPKAPK2,MAPK14 R-HSA-451927 |Interleukin-2 signaling |0.235810232570235 |-1.44472789669642|262 |43 |0.028457974851092 |1511 |10287 |DUSP9,PSMF1,RASGRF1,PSMD3,PSME3,PPP2CA,GRIN2A,PSMD1,ERBB3,FGFR3,FN1,PIK3R1,SPTBN1,PSMD12,SPRED2,PDGFB,FGF17,INPP5D,PSMD14,PSMA6,WDR83,PSMD7,PTPRA,PSMB11,ERBB2,SPTBN2,SOS1,SRC,PSMC5,PSMD9,STAT5B,LAMTOR2,STAT5A,UBA52,PSMB10,KSR1,RPS27A,SHC2,AKAP9,GRB2,PTK2B,PSMB3,ARRB1 R-HSA-168898 |Toll-Like Receptors Cascades |0.238853116808138 |-1.43190649000318|153 |26 |0.0172071475843812 |1511 |10287 |RBSN,APOB,MAPKAPK2,RIPK1,MAPK14,PPP2CA,JUN,LBP,DNM2,ATF2,CREB1,SOCS1,CD180,CTSB,DUSP3,ITGB2,UBA52,IRAK2,RPS27A,S100A1,MAPK9,MAPKAPK3,NFKBIA,RELA,MAP2K7,NFKBIB R-HSA-73923 |Lipid digestion, mobilization, and transport |0.239802376801157 |-1.42794012484002|115 |20 |0.0132362673726009 |1511 |10287 |FITM2,APOB,ANGPTL8,FURIN,MBTPS1,PRKACA,APOE,APOA2,AP2M1,PLTP,LCAT,CLTC,APOC3,SCARB1,LSR,PCSK6,RELN,LMF1,HDLBP,ABCA1 R-HSA-187687 |Signalling to ERKs |0.244058410689476 |-1.41034769426607|263 |43 |0.028457974851092 |1511 |10287 |RALGDS,DUSP9,RASGRF1,PSMD3,MAPKAPK2,PSMF1,MAPK14,PPP2CA,PSME3,GRIN2A,FGFR3,ERBB3,PSMD1,SPTBN1,FN1,PSMD12,PDGFB,SPRED2,PSMD14,FGF17,PSMA6,PTPRA,WDR83,RALB,PSMD7,PSMB11,ERBB2,SPTBN2,SRC,SOS1,PSMD9,PSMC5,LAMTOR2,PSMB10,UBA52,RPS27A,KSR1,SHC2,MAPKAPK3,GRB2,AKAP9,PSMB3,ARRB1 R-HSA-168138 |Toll Like Receptor 9 (TLR9) Cascade |0.251975356403069 |-1.37842398830398|97 |17 |0.0112508272667108 |1511 |10287 |ATF2,CREB1,PPP2CA,JUN,MAPKAPK2,MAPK14,RBSN,NFKBIA,RELA,MAP2K7,NFKBIB,MAPK9,MAPKAPK3,IRAK2,RPS27A,DUSP3,UBA52 R-HSA-975138 |TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |0.256204536803795 |-1.36177918162088|91 |16 |0.0105890138980807 |1511 |10287 |UBA52,DUSP3,RPS27A,IRAK2,MAPKAPK3,MAPK9,RELA,NFKBIA,MAP2K7,NFKBIB,MAPKAPK2,MAPK14,PPP2CA,JUN,CREB1,ATF2 R-HSA-512988 |Interleukin-3, 5 and GM-CSF signaling |0.256618570199104 |-1.36016445919666|271 |44 |0.029119788219722 |1511 |10287 |FGFR3,PSMD1,PRKACA,ERBB3,SPTBN1,FN1,PIK3R1,PPP2CA,PSME3,GRIN2A,PSMD3,RASGRF1,HCK,PSMF1,DUSP9,PTPRA,PSMD7,WDR83,PSMD14,FGF17,INPP5D,PSMA6,PDGFB,SPRED2,PSMD12,STAT5B,PSMD9,PSMC5,SPTBN2,ERBB2,SRC,SOS1,PSMB11,PSMB3,ARRB1,GRB2,AKAP9,RPS27A,KSR1,SHC2,LAMTOR2,PSMB10,UBA52,STAT5A R-HSA-5218921|VEGFR2 mediated cell proliferation |0.256695948992518 |-1.35986297232611|258 |42 |0.0277961614824619 |1511 |10287 |PSMD12,SPRED2,PDGFB,PSMD14,FGF17,PSMA6,PTPRA,WDR83,PSMD7,DUSP9,PSMD3,RASGRF1,PSMF1,PSME3,PPP2CA,GRIN2A,FGFR3,PSMD1,ERBB3,SPTBN1,FN1,LAMTOR2,UBA52,PSMB10,RPS27A,KSR1,SHC2,GRB2,AKAP9,PSMB3,VEGFA,ARRB1,SPHK1,PSMB11,ITPR3,ERBB2,SPTBN2,SRC,SOS1,PSMC5,PSMD9,PRKCD R-HSA-111885 |Opioid Signalling |0.260516807046694 |-1.34508790145653|85 |15 |0.0099272005294507 |1511 |10287 |PLCB1,GNAT1,PRKAR1A,ITPR3,GNB5,GNB1,PRKAR2A,GNAI3,ADCY4,PPP2CA,PRKCD,PRKACA,PDE4D,CREB1,GNGT2 R-HSA-2871796|FCERI mediated MAPK activation |0.26094064399959 |-1.34346231514885|265 |43 |0.028457974851092 |1511 |10287 |PSMB10,UBA52,LAMTOR2,SHC2,KSR1,RPS27A,AKAP9,GRB2,ARRB1,PSMB3,PSMB11,SOS1,SRC,ERBB2,SPTBN2,JUN,PSMC5,PSMD9,VAV2,PSMD12,SPRED2,PDGFB,PSMA6,FGF17,MAPK9,PSMD14,MAP2K7,WDR83,PSMD7,PTPRA,DUSP9,VAV3,PSMF1,RASGRF1,PSMD3,GRIN2A,PPP2CA,PSME3,FN1,SPTBN1,ERBB3,PSMD1,FGFR3