TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols ko04136 Autophagy - other 0.900148194205104 -0.10519586898494 32 2 0.00213675213675214 936 8063 242557,74244 Atg4c,Atg7 mmu04136 Autophagy - other 0.900148194205104 -0.10519586898494 32 2 0.00213675213675214 936 8063 242557,74244 Atg4c,Atg7 M00341 Proteasome, 19S regulatory particle (PA700) 0.904373056518001 -0.10051333057672 19 1 0.00106837606837607 936 8063 20422 Sem1 ko00100 Steroid biosynthesis 0.904373056518001 -0.10051333057672 19 1 0.00106837606837607 936 8063 66234 Msmo1 mmu_M00341 Proteasome, 19S regulatory particle (PA700) 0.904373056518001 -0.10051333057672 19 1 0.00106837606837607 936 8063 20422 Sem1 mmu00100 Steroid biosynthesis 0.904373056518001 -0.10051333057672 19 1 0.00106837606837607 936 8063 66234 Msmo1 ko00410 beta-Alanine metabolism 0.909546703327135 -0.0948089317902547 33 2 0.00213675213675214 936 8063 93747,228608 Echs1,Smox mmu00410 beta-Alanine metabolism 0.909546703327135 -0.0948089317902547 33 2 0.00213675213675214 936 8063 228608,93747 Smox,Echs1 ko00380 Tryptophan metabolism 0.915310939041576 -0.0884914473445899 46 3 0.00320512820512821 936 8063 13195,93747,15107 Ddc,Echs1,Hadh mmu00380 Tryptophan metabolism 0.915310939041576 -0.0884914473445899 46 3 0.00320512820512821 936 8063 13195,93747,15107 Ddc,Echs1,Hadh M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP 0.915500209555837 -0.0882846859699057 20 1 0.00106837606837607 936 8063 11637 Ak2 mmu_M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP 0.915500209555837 -0.0882846859699057 20 1 0.00106837606837607 936 8063 11637 Ak2 ko00531 Glycosaminoglycan degradation 0.925333829330551 -0.0776007100036471 21 1 0.00106837606837607 936 8063 15931 Ids mmu00531 Glycosaminoglycan degradation 0.925333829330551 -0.0776007100036471 21 1 0.00106837606837607 936 8063 15931 Ids ko05340 Primary immunodeficiency 0.93300278905679 -0.0693470887965064 36 2 0.00213675213675214 936 8063 54167,72049 Icos,Tnfrsf13c mmu05340 Primary immunodeficiency 0.93300278905679 -0.0693470887965064 36 2 0.00213675213675214 936 8063 54167,72049 Icos,Tnfrsf13c ko00514 Other types of O-glycan biosynthesis 0.934024147145372 -0.0682529876127871 22 1 0.00106837606837607 936 8063 20440 St6gal1 mmu00514 Other types of O-glycan biosynthesis 0.934024147145372 -0.0682529876127871 22 1 0.00106837606837607 936 8063 20440 St6gal1 ko03015 mRNA surveillance pathway 0.939807083060328 -0.0620806555676927 96 7 0.00747863247863248 936 8063 226849,225363,26931,226517,18459,73699,228410 Ppp2r5a,Etf1,Ppp2r5c,Smg7,Pabpc2,Ppp2r1b,Cstf3 mmu03015 mRNA surveillance pathway 0.939807083060328 -0.0620806555676927 96 7 0.00747863247863248 936 8063 73699,228410,26931,225363,226849,18459,226517 Ppp2r1b,Cstf3,Ppp2r5c,Etf1,Ppp2r5a,Pabpc2,Smg7 mmu04650 Natural killer cell mediated cytotoxicity 0.941024506636612 -0.0607860965513777 118 9 0.00961538461538462 936 8063 18479,234779,16415,18750,20663,19057,19055,18706,216148 Pak1,Plcg2,Itgb2l,Prkca,Sos2,Ppp3cc,Ppp3ca,Pik3ca,Shc2 ko04650 Natural killer cell mediated cytotoxicity 0.941024506636612 -0.0607860965513777 118 9 0.00961538461538462 936 8063 216148,18706,19055,20663,19057,18750,16415,234779,18479 Shc2,Pik3ca,Ppp3ca,Sos2,Ppp3cc,Prkca,Itgb2l,Plcg2,Pak1 mmu00515 Mannose type O-glycan biosynthesis 0.941703962879848 -0.0600643182559568 23 1 0.00106837606837607 936 8063 228366 Large2 ko00515 Mannose type O-glycan biosynthesis 0.941703962879848 -0.0600643182559568 23 1 0.00106837606837607 936 8063 228366 Large2 mmu_M00177 Ribosome, eukaryotes 0.947437997065326 -0.0539937826202269 98 7 0.00747863247863248 936 8063 267019,20068,114641,56040,14109,19946,20044 Rps15a,Rps17,Rpl31,Rplp1,Fau,Rpl30,Rps14 M00177 Ribosome, eukaryotes 0.947437997065326 -0.0539937826202269 98 7 0.00747863247863248 936 8063 20044,19946,56040,14109,114641,267019,20068 Rps14,Rpl30,Rplp1,Fau,Rpl31,Rps15a,Rps17 M00129 Ascorbate biosynthesis, animals, glucose-1P => ascorbate 0.948490665711843 -0.0528833307605597 24 1 0.00106837606837607 936 8063 216558 Ugp2 mmu_M00129 Ascorbate biosynthesis, animals, glucose-1P => ascorbate 0.948490665711843 -0.0528833307605597 24 1 0.00106837606837607 936 8063 216558 Ugp2 ko05150 Staphylococcus aureus infection 0.950341543958823 -0.0509338390427088 52 3 0.00320512820512821 936 8063 16153,17195,16415 Il10,Mbl2,Itgb2l mmu05150 Staphylococcus aureus infection 0.950341543958823 -0.0509338390427088 52 3 0.00320512820512821 936 8063 16415,17195,16153 Itgb2l,Mbl2,Il10 ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.954488020706351 -0.0465801862289293 25 1 0.00106837606837607 936 8063 329777 Pigk mmu00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.954488020706351 -0.0465801862289293 25 1 0.00106837606837607 936 8063 329777 Pigk ko05310 Asthma 0.954488020706351 -0.0465801862289293 25 1 0.00106837606837607 936 8063 16153 Il10 mmu05310 Asthma 0.954488020706351 -0.0465801862289293 25 1 0.00106837606837607 936 8063 16153 Il10 ko00590 Arachidonic acid metabolism 0.955187318998663 -0.0458478121870912 89 6 0.00641025641025641 936 8063 665270,18783,230639,54486,21391,11684 Plb1,Pla2g4a,Cyp4a29,Hpgds,Tbxas1,Alox12 mmu00590 Arachidonic acid metabolism 0.955187318998663 -0.0458478121870912 89 6 0.00641025641025641 936 8063 11684,54486,21391,18783,665270,230639 Alox12,Hpgds,Tbxas1,Pla2g4a,Plb1,Cyp4a29 mmu05012 Parkinson's disease 0.955423564587398 -0.0456005137005515 144 11 0.0117521367521368 936 8063 22333,22334,214084,12867,68375,21823,28080,239760,20463,18951,50873 Vdac1,Vdac2,Slc18a2,Cox7c,Ndufa8,Th,Atp5o,Ndufa11b,Cox7a2l,Sept5,Prkn ko05033 Nicotine addiction 0.955436781813794 -0.0455866799042496 40 2 0.00213675213675214 936 8063 12287,14811 Cacna1b,Grin2a mmu05033 Nicotine addiction 0.955436781813794 -0.0455866799042496 40 2 0.00213675213675214 936 8063 12287,14811 Cacna1b,Grin2a ko05320 Autoimmune thyroid disease 0.960362224845014 -0.0404447481397302 79 5 0.00534188034188034 936 8063 12477,12487,21819,16153,22018 Ctla4,Cd28,Tg,Il10,Tpo mmu05320 Autoimmune thyroid disease 0.960362224845014 -0.0404447481397302 79 5 0.00534188034188034 936 8063 16153,22018,12477,21819,12487 Il10,Tpo,Ctla4,Tg,Cd28 ko04940 Type I diabetes mellitus 0.969339809397442 -0.0311400480726876 70 4 0.00427350427350427 936 8063 12876,19276,12487,16160 Cpe,Ptprn2,Cd28,Il12b mmu04940 Type I diabetes mellitus 0.969339809397442 -0.0311400480726876 70 4 0.00427350427350427 936 8063 16160,12487,19276,12876 Il12b,Cd28,Ptprn2,Cpe mmu03420 Nucleotide excision repair 0.970575609806881 -0.0298659713120461 44 2 0.00213675213675214 936 8063 16881,67967 Lig1,Pold3 ko03420 Nucleotide excision repair 0.970575609806881 -0.0298659713120461 44 2 0.00213675213675214 936 8063 16881,67967 Lig1,Pold3 mmu00630 Glyoxylate and dicarboxylate metabolism 0.972265927342635 -0.028125924138951 29 1 0.00106837606837607 936 8063 15112 Hao1 ko00630 Glyoxylate and dicarboxylate metabolism 0.972265927342635 -0.028125924138951 29 1 0.00106837606837607 936 8063 15112 Hao1 ko00480 Glutathione metabolism 0.974024521024807 -0.0263188000663509 59 3 0.00320512820512821 936 8063 20133,54486,14782 Rrm1,Hpgds,Gsr mmu00480 Glutathione metabolism 0.974024521024807 -0.0263188000663509 59 3 0.00320512820512821 936 8063 14782,20133,54486 Gsr,Rrm1,Hpgds ko03050 Proteasome 0.976148005420387 -0.0241410591680324 46 2 0.00213675213675214 936 8063 20422,26440 Sem1,Psma1 mmu03050 Proteasome 0.976148005420387 -0.0241410591680324 46 2 0.00213675213675214 936 8063 26440,20422 Psma1,Sem1 ko03040 Spliceosome 0.977732388335556 -0.022519277950002 133 9 0.00961538461538462 936 8063 107686,67678,76938,71702,78651,68981,76522,15481,229279 Snrpd2,Lsm3,Rbm17,Cdc5l,Lsm6,Snrpa1,Lsm8,Hspa8,Hnrnpa3 mmu03040 Spliceosome 0.977732388335556 -0.022519277950002 133 9 0.00961538461538462 936 8063 76938,71702,78651,107686,67678,15481,229279,76522,68981 Rbm17,Cdc5l,Lsm6,Snrpd2,Lsm3,Hspa8,Hnrnpa3,Lsm8,Snrpa1 ko04130 SNARE interactions in vesicular transport 0.983103858576589 -0.0170405097094346 33 1 0.00106837606837607 936 8063 20908 Stx3 mmu04130 SNARE interactions in vesicular transport 0.983103858576589 -0.0170405097094346 33 1 0.00106837606837607 936 8063 20908 Stx3 mmu05330 Allograft rejection 0.983875142088453 -0.0162562781023533 64 3 0.00320512820512821 936 8063 12487,16160,16153 Cd28,Il12b,Il10 ko05330 Allograft rejection 0.983875142088453 -0.0162562781023533 64 3 0.00320512820512821 936 8063 16160,12487,16153 Il12b,Cd28,Il10 mmu05168 Herpes simplex infection 0.983990676082336 -0.0161388575008583 215 16 0.0170940170940171 936 8063 14082,22031,56489,16160,16150,68652,72504,106759,216150,26419,228980,27401,16452,26420,54721,16451 Fadd,Traf3,Ikbke,Il12b,Ikbkb,Tab2,Taf4b,Ticam1,Cdc34,Mapk8,Taf4,Skp2,Jak2,Mapk9,Tyk2,Jak1 ko05168 Herpes simplex infection 0.983990676082336 -0.0161388575008583 215 16 0.0170940170940171 936 8063 26420,16452,16451,54721,27401,106759,216150,228980,26419,72504,16150,68652,56489,16160,22031,14082 Mapk9,Jak2,Jak1,Tyk2,Skp2,Ticam1,Cdc34,Taf4,Mapk8,Taf4b,Ikbkb,Tab2,Ikbke,Il12b,Traf3,Fadd mmu00591 Linoleic acid metabolism 0.984393612308955 -0.0157294494044578 50 2 0.00213675213675214 936 8063 665270,18783 Plb1,Pla2g4a ko00591 Linoleic acid metabolism 0.984393612308955 -0.0157294494044578 50 2 0.00213675213675214 936 8063 18783,665270 Pla2g4a,Plb1 ko00040 Pentose and glucuronate interconversions 0.985073321633001 -0.0150392023743421 34 1 0.00106837606837607 936 8063 216558 Ugp2 mmu00040 Pentose and glucuronate interconversions 0.985073321633001 -0.0150392023743421 34 1 0.00106837606837607 936 8063 216558 Ugp2 ko00830 Retinol metabolism 0.994451084132118 -0.00556436829084456 89 4 0.00427350427350427 936 8063 20148,230639,67442,232174 Dhrs3,Cyp4a29,Retsat,Cyp26b1 mmu00830 Retinol metabolism 0.994451084132118 -0.00556436829084456 89 4 0.00427350427350427 936 8063 20148,67442,230639,232174 Dhrs3,Retsat,Cyp4a29,Cyp26b1 mmu00982 Drug metabolism - cytochrome P450 0.997553387181223 -0.00244961066663337 67 2 0.00213675213675214 936 8063 226564,54486 Fmo4,Hpgds ko00982 Drug metabolism - cytochrome P450 0.997553387181223 -0.00244961066663337 67 2 0.00213675213675214 936 8063 226564,54486 Fmo4,Hpgds ko00983 Drug metabolism - other enzymes 0.998189262343099 -0.00181237902402119 51 1 0.00106837606837607 936 8063 22247 Umps mmu00983 Drug metabolism - other enzymes 0.998189262343099 -0.00181237902402119 51 1 0.00106837606837607 936 8063 22247 Umps ko05322 Systemic lupus erythematosus 0.99825634582494 -0.00174517610940977 142 7 0.00747863247863248 936 8063 110382,319177,16153,12487,109711,236663,14811 C8b,Hist1h2ba,Il10,Cd28,Actn1,H2al1j,Grin2a mmu05322 Systemic lupus erythematosus 0.99825634582494 -0.00174517610940977 142 7 0.00747863247863248 936 8063 109711,12487,236663,14811,110382,16153,319177 Actn1,Cd28,H2al1j,Grin2a,C8b,Il10,Hist1h2ba mmu00140 Steroid hormone biosynthesis 0.998391533858364 -0.00160976111209795 87 3 0.00320512820512821 936 8063 56348,15487,15484 Hsd17b12,Hsd17b3,Hsd11b2 ko00140 Steroid hormone biosynthesis 0.998391533858364 -0.00160976111209795 87 3 0.00320512820512821 936 8063 15487,56348,15484 Hsd17b3,Hsd17b12,Hsd11b2 mmu05416 Viral myocarditis 0.99854977459948 -0.0014512779951656 88 3 0.00320512820512821 936 8063 24052,16415,12487 Sgcd,Itgb2l,Cd28 mmu03010 Ribosome 0.999196192015914 -0.000804131210943094 177 9 0.00961538461538462 936 8063 267019,20068,14109,114641,64657,19946,20044,56040,68565 Rps15a,Rps17,Fau,Rpl31,Mrps10,Rpl30,Rps14,Rplp1,Mrps18a ko03010 Ribosome 0.999196192015914 -0.000804131210943094 177 9 0.00961538461538462 936 8063 267019,20068,14109,114641,64657,20044,19946,68565,56040 Rps15a,Rps17,Fau,Rpl31,Mrps10,Rps14,Rpl30,Mrps18a,Rplp1 mmu00980 Metabolism of xenobiotics by cytochrome P450 0.999682415994129 -0.000317634446351446 65 1 0.00106837606837607 936 8063 54486 Hpgds mmu05332 Graft-versus-host disease 0.999682415994129 -0.000317634446351446 65 1 0.00106837606837607 936 8063 12487 Cd28 ko00980 Metabolism of xenobiotics by cytochrome P450 0.999682415994129 -0.000317634446351446 65 1 0.00106837606837607 936 8063 54486 Hpgds ko05332 Graft-versus-host disease 0.999682415994129 -0.000317634446351446 65 1 0.00106837606837607 936 8063 12487 Cd28 mmu03013 RNA transport 0.99980688891259 -0.000193129735756516 167 7 0.00747863247863248 936 8063 218210,18459,71805,107939,68135,66231,76884 Nup153,Pabpc2,Nup93,Pom121,Eif3h,Thoc7,Cyfip2 ko03013 RNA transport 0.99980688891259 -0.000193129735756516 167 7 0.00747863247863248 936 8063 218210,18459,71805,76884,68135,66231,107939 Nup153,Pabpc2,Nup93,Cyfip2,Eif3h,Thoc7,Pom121 mmu04612 Antigen processing and presentation 0.999837249259433 -0.00016276398590609 91 2 0.00213675213675214 936 8063 15481,13039 Hspa8,Ctsl ko04612 Antigen processing and presentation 0.999837249259433 -0.00016276398590609 91 2 0.00213675213675214 936 8063 15481,13039 Hspa8,Ctsl ko03008 Ribosome biogenesis in eukaryotes 0.999926405724206 -7.35969839853351e-05 116 3 0.00320512820512821 936 8063 216987,213895,14791 Utp6,Bms1,Emg1 mmu03008 Ribosome biogenesis in eukaryotes 0.999926405724206 -7.35969839853351e-05 116 3 0.00320512820512821 936 8063 14791,213895,216987 Emg1,Bms1,Utp6 ko05204 Chemical carcinogenesis 0.999990325515455 -9.67453134342972e-06 93 1 0.00106837606837607 936 8063 54486 Hpgds mmu05204 Chemical carcinogenesis 0.999990325515455 -9.67453134342972e-06 93 1 0.00106837606837607 936 8063 54486 Hpgds ko04740 Olfactory transduction 0.999999999875262 -1.24737917291569e-10 1119 11 0.0117521367521368 936 8063 12323,257951,12314,14708,259040,70405,258922,258830,258412,18573,258153 Camk2b,Olfr987,Calm2,Gng7,Olfr1416,Calml3,Olfr267,Olfr103,Olfr877,Pde1a,Olfr412 mmu04740 Olfactory transduction 0.999999999875262 -1.24737917291569e-10 1119 11 0.0117521367521368 936 8063 258153,18573,258412,258922,258830,70405,259040,12314,14708,12323,257951 Olfr412,Pde1a,Olfr877,Olfr267,Olfr103,Calml3,Olfr1416,Calm2,Gng7,Camk2b,Olfr987