TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols mmu05033 Nicotine addiction 0.903483038042363 -0.101497942737189 40 4 0.00309119010819165 1294 8063 14407,242443,14811,53623 Gabrg3,Grin3a,Grin2a,Gria3 ko05033 Nicotine addiction 0.903483038042363 -0.101497942737189 40 4 0.00309119010819165 1294 8063 53623,14811,242443,14407 Gria3,Grin2a,Grin3a,Gabrg3 ko00515 Mannose type O-glycan biosynthesis 0.90376800415403 -0.10118258409871 23 2 0.00154559505409583 1294 8063 99011,268510 Pomt1,Mgat5b mmu00515 Mannose type O-glycan biosynthesis 0.90376800415403 -0.10118258409871 23 2 0.00154559505409583 1294 8063 268510,99011 Mgat5b,Pomt1 mmu05012 Parkinson's disease 0.904021179148444 -0.100902490602845 144 18 0.0139103554868624 1294 8063 22333,84682,214084,22335,105675,14677,50873,67680,12865,12869,14678,28080,12859,67128,17993,12867,18951,68375 Vdac1,Cox4i2,Slc18a2,Vdac3,Ppif,Gnai1,Prkn,Sdhb,Cox7a1,Cox8b,Gnai2,Atp5o,Cox5b,Ube2g1,Ndufs4,Cox7c,Sept5,Ndufa8 M00055 N-glycan precursor biosynthesis 0.913811005454542 -0.0901315063114143 14 1 0.000772797527047913 1294 8063 320302 Glt28d2 mmu00790 Folate biosynthesis 0.913811005454542 -0.0901315063114143 14 1 0.000772797527047913 1294 8063 14590 Ggh ko00790 Folate biosynthesis 0.913811005454542 -0.0901315063114143 14 1 0.000772797527047913 1294 8063 14590 Ggh mmu_M00055 N-glycan precursor biosynthesis 0.913811005454542 -0.0901315063114143 14 1 0.000772797527047913 1294 8063 320302 Glt28d2 ko04742 Taste transduction 0.916766282940248 -0.0869027105955839 88 10 0.00772797527047913 1294 8063 242851,18575,20269,12288,16529,15550,57254,330953,64337,20278 Gnat3,Pde1c,Scn3a,Cacna1c,Kcnk5,Htr1a,Tas2r119,Hcn4,Gng13,Scnn1g mmu04742 Taste transduction 0.916766282940248 -0.0869027105955839 88 10 0.00772797527047913 1294 8063 242851,18575,20269,12288,15550,16529,57254,330953,64337,20278 Gnat3,Pde1c,Scn3a,Cacna1c,Htr1a,Kcnk5,Tas2r119,Hcn4,Gng13,Scnn1g ko00970 Aminoacyl-tRNA biosynthesis 0.922538649787069 -0.0806260071569503 66 7 0.00540958268933539 1294 8063 20226,23874,76563,68915,110960,69955,229487 Sars,Farsb,Qrsl1,Vars2,Tars,Fars2,Gatb mmu00970 Aminoacyl-tRNA biosynthesis 0.922538649787069 -0.0806260071569503 66 7 0.00540958268933539 1294 8063 110960,229487,69955,23874,76563,68915,20226 Tars,Gatb,Fars2,Farsb,Qrsl1,Vars2,Sars M00340 Proteasome, 20S core particle 0.927667206090744 -0.0750822246397124 15 1 0.000772797527047913 1294 8063 19167 Psma3 mmu_M00340 Proteasome, 20S core particle 0.927667206090744 -0.0750822246397124 15 1 0.000772797527047913 1294 8063 19167 Psma3 mmu03022 Basal transcription factors 0.938499116723432 -0.0634733641137878 44 4 0.00309119010819165 1294 8063 68153,83602,68705,12572 Gtf2e2,Gtf2a1,Gtf2f2,Cdk7 ko03022 Basal transcription factors 0.938499116723432 -0.0634733641137878 44 4 0.00309119010819165 1294 8063 68153,83602,12572,68705 Gtf2e2,Gtf2a1,Cdk7,Gtf2f2 mmu05016 Huntington's disease 0.938663183429608 -0.0632985612141334 194 24 0.0185471406491499 1294 8063 19017,22333,26427,84682,19016,75563,13411,22335,73916,105675,19712,67665,67680,12869,22227,12865,12859,327954,28080,68375,18798,12867,17993,208647 Ppargc1a,Vdac1,Creb3l1,Cox4i2,Pparg,Dnali1,Dnah11,Vdac3,Ift57,Ppif,Rest,Dctn4,Sdhb,Cox8b,Ucp1,Cox7a1,Cox5b,Dnah2,Atp5o,Ndufa8,Plcb4,Cox7c,Ndufs4,Creb3l2 ko05016 Huntington's disease 0.938663183429608 -0.0632985612141334 194 24 0.0185471406491499 1294 8063 105675,19712,67665,73916,22335,75563,26427,84682,19016,13411,19017,22333,18798,68375,208647,17993,12867,12859,28080,327954,22227,12869,12865,67680 Ppif,Rest,Dctn4,Ift57,Vdac3,Dnali1,Creb3l1,Cox4i2,Pparg,Dnah11,Ppargc1a,Vdac1,Plcb4,Ndufa8,Creb3l2,Ndufs4,Cox7c,Cox5b,Atp5o,Dnah2,Ucp1,Cox8b,Cox7a1,Sdhb mmu_M00146 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 0.939297255234804 -0.0626232841249718 16 1 0.000772797527047913 1294 8063 68375 Ndufa8 M00146 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 0.939297255234804 -0.0626232841249718 16 1 0.000772797527047913 1294 8063 68375 Ndufa8 ko00120 Primary bile acid biosynthesis 0.939297255234804 -0.0626232841249718 16 1 0.000772797527047913 1294 8063 15488 Hsd17b4 mmu00120 Primary bile acid biosynthesis 0.939297255234804 -0.0626232841249718 16 1 0.000772797527047913 1294 8063 15488 Hsd17b4 ko05340 Primary immunodeficiency 0.943495829177013 -0.0581633347694045 36 3 0.00231839258114374 1294 8063 72049,227525,54167 Tnfrsf13c,Dclre1c,Icos mmu05340 Primary immunodeficiency 0.943495829177013 -0.0581633347694045 36 3 0.00231839258114374 1294 8063 227525,72049,54167 Dclre1c,Tnfrsf13c,Icos mmu03013 RNA transport 0.944579267519049 -0.0570156701846096 167 20 0.0154559505409583 1294 8063 68626,227720,13690,114671,67676,72787,208366,56488,69482,110379,66231,230721,195236,18459,56347,12729,218210,54563,51796,21335 Elac2,Nup214,Eif4g2,4930444G20Rik,Rpp21,Ndc1,Rpp40,Nxt1,Nup35,Sec13,Thoc7,Pabpc4,Pom121l2,Pabpc2,Eif3c,Clns1a,Nup153,Nup210,Srrm1,Tacc3 ko03013 RNA transport 0.944579267519049 -0.0570156701846096 167 20 0.0154559505409583 1294 8063 218210,54563,195236,56347,18459,12729,230721,51796,21335,227720,13690,68626,56488,208366,72787,67676,114671,66231,69482,110379 Nup153,Nup210,Pom121l2,Eif3c,Pabpc2,Clns1a,Pabpc4,Srrm1,Tacc3,Nup214,Eif4g2,Elac2,Nxt1,Rpp40,Ndc1,Rpp21,4930444G20Rik,Thoc7,Nup35,Sec13 mmu00053 Ascorbate and aldarate metabolism 0.945522872415956 -0.0560172003608226 27 2 0.00154559505409583 1294 8063 268756,19733 Gulo,Rgn ko00053 Ascorbate and aldarate metabolism 0.945522872415956 -0.0560172003608226 27 2 0.00154559505409583 1294 8063 19733,268756 Rgn,Gulo M00158 F-type ATPase, eukaryotes 0.949058576419616 -0.0522847579149968 17 1 0.000772797527047913 1294 8063 28080 Atp5o mmu_M00158 F-type ATPase, eukaryotes 0.949058576419616 -0.0522847579149968 17 1 0.000772797527047913 1294 8063 28080 Atp5o ko04610 Complement and coagulation cascades 0.952540460802003 -0.0486226943511815 87 9 0.00695517774343122 1294 8063 109821,232345,12509,14062,12279,18816,110382,22371,99571 F11,A2m,Cd59a,F2r,C9,Serpinf2,C8b,Vwf,Fgg mmu04610 Complement and coagulation cascades 0.952540460802003 -0.0486226943511815 87 9 0.00695517774343122 1294 8063 12279,14062,22371,110382,99571,18816,109821,12509,232345 C9,F2r,Vwf,C8b,Fgg,Serpinf2,F11,Cd59a,A2m mmu_M00337 Immunoproteasome 0.957251243868694 -0.0436893892067281 18 1 0.000772797527047913 1294 8063 19167 Psma3 M00337 Immunoproteasome 0.957251243868694 -0.0436893892067281 18 1 0.000772797527047913 1294 8063 19167 Psma3 mmu00591 Linoleic acid metabolism 0.96979961859165 -0.0306658075965372 50 4 0.00309119010819165 1294 8063 53357,18778,18783,18784 Pla2g6,Pla2g1b,Pla2g4a,Pla2g5 ko00591 Linoleic acid metabolism 0.96979961859165 -0.0306658075965372 50 4 0.00309119010819165 1294 8063 18784,18778,53357,18783 Pla2g5,Pla2g1b,Pla2g6,Pla2g4a mmu_M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP 0.969897868192199 -0.030564503551651 20 1 0.000772797527047913 1294 8063 18102 Nme1 M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP 0.969897868192199 -0.030564503551651 20 1 0.000772797527047913 1294 8063 18102 Nme1 mmu00983 Drug metabolism - other enzymes 0.973271806644726 -0.0270918867372134 51 4 0.00309119010819165 1294 8063 22247,103149,76654,99586 Umps,Upb1,Upp2,Dpyd ko00983 Drug metabolism - other enzymes 0.973271806644726 -0.0270918867372134 51 4 0.00309119010819165 1294 8063 99586,76654,103149,22247 Dpyd,Upp2,Upb1,Umps mmu_M00354 Spliceosome, U4/U6.U5 tri-snRNP 0.973830298660971 -0.0265182218738867 32 2 0.00154559505409583 1294 8063 20643,67678 Snrpe,Lsm3 M00354 Spliceosome, U4/U6.U5 tri-snRNP 0.973830298660971 -0.0265182218738867 32 2 0.00154559505409583 1294 8063 67678,20643 Lsm3,Snrpe mmu04940 Type I diabetes mellitus 0.977357244949516 -0.0229030387599996 70 6 0.00463678516228748 1294 8063 15893,12487,16160,16176,12519,19276 Ica1,Cd28,Il12b,Il1b,Cd80,Ptprn2 ko04940 Type I diabetes mellitus 0.977357244949516 -0.0229030387599996 70 6 0.00463678516228748 1294 8063 15893,16176,16160,12487,12519,19276 Ica1,Il1b,Il12b,Cd28,Cd80,Ptprn2 mmu05416 Viral myocarditis 0.979937845531768 -0.0202661322556059 88 8 0.00618238021638331 1294 8063 11350,12487,19353,24052,16773,12389,12519,13690 Abl1,Cd28,Rac1,Sgcd,Lama2,Cav1,Cd80,Eif4g2 ko00830 Retinol metabolism 0.981869806688988 -0.0182965591635905 89 8 0.00618238021638331 1294 8063 63857,27400,230639,28200,71872,20148,67442,232174 Bco1,Hsd17b6,Cyp4a29,Dhrs4,Aox4,Dhrs3,Retsat,Cyp26b1 mmu00830 Retinol metabolism 0.981869806688988 -0.0182965591635905 89 8 0.00618238021638331 1294 8063 230639,28200,63857,27400,67442,232174,71872,20148 Cyp4a29,Dhrs4,Bco1,Hsd17b6,Retsat,Cyp26b1,Aox4,Dhrs3 ko05310 Asthma 0.987480110999078 -0.0125989231701156 25 1 0.000772797527047913 1294 8063 16163 Il13 mmu05310 Asthma 0.987480110999078 -0.0125989231701156 25 1 0.000772797527047913 1294 8063 16163 Il13 ko00190 Oxidative phosphorylation 0.987963070272391 -0.0121099601996649 134 13 0.0100463678516229 1294 8063 338375,68375,12867,17993,66335,76429,12859,28080,12869,84682,11974,12865,67680 Atp6v1g3,Ndufa8,Cox7c,Ndufs4,Atp6v1c1,Lhpp,Cox5b,Atp5o,Cox8b,Cox4i2,Atp6v0e,Cox7a1,Sdhb mmu00190 Oxidative phosphorylation 0.987963070272391 -0.0121099601996649 134 13 0.0100463678516229 1294 8063 12859,28080,68375,338375,66335,76429,12867,17993,67680,11974,12869,84682,12865 Cox5b,Atp5o,Ndufa8,Atp6v1g3,Atp6v1c1,Lhpp,Cox7c,Ndufs4,Sdhb,Atp6v0e,Cox8b,Cox4i2,Cox7a1 mmu_M00177 Ribosome, eukaryotes 0.992951908512732 -0.00707304661053256 98 8 0.00618238021638331 1294 8063 67025,100502825,11837,267019,57808,225215,20090,56040 Rpl11,Rpl37rt,Rplp0,Rps15a,Rpl35a,Rsl24d1,Rps29,Rplp1 M00177 Ribosome, eukaryotes 0.992951908512732 -0.00707304661053256 98 8 0.00618238021638331 1294 8063 67025,100502825,11837,267019,57808,225215,56040,20090 Rpl11,Rpl37rt,Rplp0,Rps15a,Rpl35a,Rsl24d1,Rplp1,Rps29 mmu00860 Porphyrin and chlorophyll metabolism 0.993312022320809 -0.00671044242039204 41 2 0.00154559505409583 1294 8063 14297,15369 Fxn,Hmox2 ko00860 Porphyrin and chlorophyll metabolism 0.993312022320809 -0.00671044242039204 41 2 0.00154559505409583 1294 8063 14297,15369 Fxn,Hmox2 mmu05150 Staphylococcus aureus infection 0.993467350712038 -0.0065540804270533 52 3 0.00231839258114374 1294 8063 14293,99571,20345 Fpr1,Fgg,Selplg ko05150 Staphylococcus aureus infection 0.993467350712038 -0.0065540804270533 52 3 0.00231839258114374 1294 8063 20345,14293,99571 Selplg,Fpr1,Fgg ko03040 Spliceosome 0.993777787038841 -0.00624165160442753 133 12 0.00927357032457496 1294 8063 23983,71702,20643,229279,15511,15387,67678,15481,66642,67439,81898,14105 Pcbp1,Cdc5l,Snrpe,Hnrnpa3,Hspa1b,Hnrnpk,Lsm3,Hspa8,Ctnnbl1,Xab2,Sf3b1,Srsf10 mmu03040 Spliceosome 0.993777787038841 -0.00624165160442753 133 12 0.00927357032457496 1294 8063 67678,15387,15481,66642,81898,14105,67439,23983,71702,20643,229279,15511 Lsm3,Hnrnpk,Hspa8,Ctnnbl1,Sf3b1,Srsf10,Xab2,Pcbp1,Cdc5l,Snrpe,Hnrnpa3,Hspa1b mmu05168 Herpes simplex infection 0.994974459907513 -0.00503821058764444 215 22 0.0170015455950541 1294 8063 18035,13000,16476,56489,15387,22034,26420,22031,16452,16176,11865,216150,26419,12534,54721,27103,16160,18988,58235,19247,68652,15957 Nfkbia,Csnk2a2,Jun,Ikbke,Hnrnpk,Traf6,Mapk9,Traf3,Jak2,Il1b,Arntl,Cdc34,Mapk8,Cdk1,Tyk2,Eif2ak4,Il12b,Pou2f3,Nectin1,Ptpn11,Tab2,Ifit1 ko05168 Herpes simplex infection 0.994974459907513 -0.00503821058764444 215 22 0.0170015455950541 1294 8063 26419,12534,216150,11865,16176,16452,22031,58235,19247,18988,68652,15957,16160,54721,27103,56489,13000,18035,16476,26420,22034,15387 Mapk8,Cdk1,Cdc34,Arntl,Il1b,Jak2,Traf3,Nectin1,Ptpn11,Pou2f3,Tab2,Ifit1,Il12b,Tyk2,Eif2ak4,Ikbke,Csnk2a2,Nfkbia,Jun,Mapk9,Traf6,Hnrnpk mmu00982 Drug metabolism - cytochrome P450 0.996608686941023 -0.00339707659543555 67 4 0.00309119010819165 1294 8063 14867,71872,17161,211666 Gstm6,Aox4,Maoa,Mgst2 ko00982 Drug metabolism - cytochrome P450 0.996608686941023 -0.00339707659543555 67 4 0.00309119010819165 1294 8063 17161,211666,71872,14867 Maoa,Mgst2,Aox4,Gstm6 mmu03008 Ribosome biogenesis in eukaryotes 0.997426282305394 -0.00257703539977186 116 9 0.00695517774343122 1294 8063 13000,14000,98956,217109,56488,208366,21453,245474,24127 Csnk2a2,Drosha,Nat10,Utp18,Nxt1,Rpp40,Tcof1,Dkc1,Xrn1 ko03008 Ribosome biogenesis in eukaryotes 0.997426282305394 -0.00257703539977186 116 9 0.00695517774343122 1294 8063 21453,24127,245474,56488,208366,98956,217109,13000,14000 Tcof1,Xrn1,Dkc1,Nxt1,Rpp40,Nat10,Utp18,Csnk2a2,Drosha mmu05330 Allograft rejection 0.998843665848383 -0.00115700322178087 64 3 0.00231839258114374 1294 8063 12519,12487,16160 Cd80,Cd28,Il12b ko05330 Allograft rejection 0.998843665848383 -0.00115700322178087 64 3 0.00231839258114374 1294 8063 12519,16160,12487 Cd80,Il12b,Cd28 mmu04623 Cytosolic DNA-sensing pathway 0.998843665848383 -0.00115700322178087 64 3 0.00231839258114374 1294 8063 16176,18035,56489 Il1b,Nfkbia,Ikbke ko04623 Cytosolic DNA-sensing pathway 0.998843665848383 -0.00115700322178087 64 3 0.00231839258114374 1294 8063 18035,16176,56489 Nfkbia,Il1b,Ikbke mmu05322 Systemic lupus erythematosus 0.998963967893119 -0.00103656915911228 142 11 0.00850077279752705 1294 8063 68231,12487,319161,319168,12519,97114,12279,14811,15081,97122,110382 H2al2a,Cd28,Hist1h4n,Hist1h2ah,Cd80,Hist2h3c2,C9,Grin2a,H3f3b,Hist2h4,C8b ko05322 Systemic lupus erythematosus 0.998963967893119 -0.00103656915911228 142 11 0.00850077279752705 1294 8063 15081,97122,110382,14811,12279,97114,12519,319168,319161,68231,12487 H3f3b,Hist2h4,C8b,Grin2a,C9,Hist2h3c2,Cd80,Hist1h2ah,Hist1h4n,H2al2a,Cd28 ko00980 Metabolism of xenobiotics by cytochrome P450 0.999002214527823 -0.000998283591473168 65 3 0.00231839258114374 1294 8063 12409,14867,211666 Cbr2,Gstm6,Mgst2 mmu00980 Metabolism of xenobiotics by cytochrome P450 0.999002214527823 -0.000998283591473168 65 3 0.00231839258114374 1294 8063 211666,12409,14867 Mgst2,Cbr2,Gstm6 ko05332 Graft-versus-host disease 0.999002214527823 -0.000998283591473168 65 3 0.00231839258114374 1294 8063 12487,16176,12519 Cd28,Il1b,Cd80 mmu05332 Graft-versus-host disease 0.999002214527823 -0.000998283591473168 65 3 0.00231839258114374 1294 8063 12519,16176,12487 Cd80,Il1b,Cd28 mmu05320 Autoimmune thyroid disease 0.999350658685803 -0.00064955222757589 79 4 0.00309119010819165 1294 8063 12487,22018,12519,21819 Cd28,Tpo,Cd80,Tg ko05320 Autoimmune thyroid disease 0.999350658685803 -0.00064955222757589 79 4 0.00309119010819165 1294 8063 12519,21819,22018,12487 Cd80,Tg,Tpo,Cd28 ko04145 Phagosome 0.999516624393258 -0.000483492470391556 184 15 0.0115919629057187 1294 8063 16412,73710,100226,338375,19353,12491,17534,66335,16398,216238,235661,13426,20778,11974,66212 Itgb1,Tubb2b,Stx12,Atp6v1g3,Rac1,Cd36,Mrc2,Atp6v1c1,Itga2,Eea1,Dync1li1,Dync1i1,Scarb1,Atp6v0e,Sec61b mmu04145 Phagosome 0.999516624393258 -0.000483492470391556 184 15 0.0115919629057187 1294 8063 338375,17534,12491,66335,19353,16412,100226,73710,11974,66212,235661,16398,216238,13426,20778 Atp6v1g3,Mrc2,Cd36,Atp6v1c1,Rac1,Itgb1,Stx12,Tubb2b,Atp6v0e,Sec61b,Dync1li1,Itga2,Eea1,Dync1i1,Scarb1 mmu00140 Steroid hormone biosynthesis 0.99979209153089 -0.000207930085071677 87 4 0.00309119010819165 1294 8063 15487,57357,15485,27400 Hsd17b3,Srd5a3,Hsd17b1,Hsd17b6 ko00140 Steroid hormone biosynthesis 0.99979209153089 -0.000207930085071677 87 4 0.00309119010819165 1294 8063 15487,57357,15485,27400 Hsd17b3,Srd5a3,Hsd17b1,Hsd17b6 ko04612 Antigen processing and presentation 0.999980943298336 -1.90568832454853e-05 91 3 0.00231839258114374 1294 8063 15511,15481,18044 Hspa1b,Hspa8,Nfya mmu04612 Antigen processing and presentation 0.999980943298336 -1.90568832454853e-05 91 3 0.00231839258114374 1294 8063 18044,15481,15511 Nfya,Hspa8,Hspa1b mmu05204 Chemical carcinogenesis 0.999998522759688 -1.47724140328782e-06 93 2 0.00154559505409583 1294 8063 14867,211666 Gstm6,Mgst2 ko05204 Chemical carcinogenesis 0.999998522759688 -1.47724140328782e-06 93 2 0.00154559505409583 1294 8063 211666,14867 Mgst2,Gstm6 mmu03010 Ribosome 0.999998604170873 -1.39583010071351e-06 177 9 0.00695517774343122 1294 8063 68565,67025,100502825,267019,11837,20090,56040,57808,225215 Mrps18a,Rpl11,Rpl37rt,Rps15a,Rplp0,Rps29,Rplp1,Rpl35a,Rsl24d1 ko03010 Ribosome 0.999998604170873 -1.39583010071351e-06 177 9 0.00695517774343122 1294 8063 68565,100502825,267019,11837,67025,20090,56040,225215,57808 Mrps18a,Rpl37rt,Rps15a,Rplp0,Rpl11,Rps29,Rplp1,Rsl24d1,Rpl35a ko04740 Olfactory transduction 0.999999999869074 -1.30926446769933e-10 1119 21 0.0162287480680062 1294 8063 18575,258502,258412,258464,108058,19735,14688,14708,19092,257667,12314,258408,238384,29845,259040,70405,19091,64337,258353,110893,259108 Pde1c,Olfr279,Olfr877,Olfr1384,Camk2d,Rgs2,Gnb1,Gng7,Prkg2,Olfr769,Calm2,Olfr463,Slc24a4,Olfr155,Olfr1416,Calml3,Prkg1,Gng13,Olfr521,Slc8a3,Olfr550 mmu04740 Olfactory transduction 0.999999999869074 -1.30926446769933e-10 1119 21 0.0162287480680062 1294 8063 12314,257667,14708,19092,14688,19735,108058,258464,258412,18575,258502,259108,258353,110893,64337,259040,19091,70405,29845,238384,258408 Calm2,Olfr769,Gng7,Prkg2,Gnb1,Rgs2,Camk2d,Olfr1384,Olfr877,Pde1c,Olfr279,Olfr550,Olfr521,Slc8a3,Gng13,Olfr1416,Prkg1,Calml3,Olfr155,Slc24a4,Olfr463