TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-MMU-68867 Assembly of the pre-replicative complex 0.905801528826014 -0.0989350600429298 67 8 0.00539083557951483 1484 8688 17463,22190,103554,66997,19167,17217,66413,13555 Psmd7,Ubc,Psme4,Psmd12,Psma3,Mcm4,Psmd6,E2f1 R-MMU-5658442 Regulation of RAS by GAPs 0.905801528826014 -0.0989350600429298 67 8 0.00539083557951483 1484 8688 17463,22190,69601,66997,103554,15461,19167,66413 Psmd7,Ubc,Dab2ip,Psmd12,Psme4,Hras,Psma3,Psmd6 R-MMU-380259 Loss of Nlp from mitotic centrosomes 0.905801528826014 -0.0989350600429298 67 8 0.00539083557951483 1484 8688 12534,18005,13589,18536,26920,381644,214444,214552 Cdk1,Nek2,Mapre1,Pcm1,Cntrl,Cep135,Cdk5rap2,Cep164 R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.905801528826014 -0.0989350600429298 67 8 0.00539083557951483 1484 8688 214552,214444,381644,26920,18536,18005,13589,12534 Cep164,Cdk5rap2,Cep135,Cntrl,Pcm1,Nek2,Mapre1,Cdk1 R-MMU-186712 Regulation of beta-cell development 0.90737723146897 -0.09719700412244 30 3 0.00202156334231806 1484 8688 15376,18012,18128 Foxa2,Neurod1,Notch1 R-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.90737723146897 -0.09719700412244 30 3 0.00202156334231806 1484 8688 22194,22190,216080 Ube2e1,Ubc,Ube2d1 R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.90737723146897 -0.09719700412244 30 3 0.00202156334231806 1484 8688 233863,269252,66596 Gtf3c1,Gtf3c4,Gtf3a R-MMU-74158 RNA Polymerase III Transcription 0.909360946546669 -0.0950131827109923 38 4 0.00269541778975741 1484 8688 66596,269252,233863,75627 Gtf3a,Gtf3c4,Gtf3c1,Snapc1 R-MMU-427359 SIRT1 negatively regulates rRNA Expression 0.909360946546669 -0.0950131827109923 38 4 0.00269541778975741 1484 8688 97122,319161,97114,15081 Hist2h4,Hist1h4n,Hist2h3c2,H3f3b R-MMU-76046 RNA Polymerase III Transcription Initiation 0.909360946546669 -0.0950131827109923 38 4 0.00269541778975741 1484 8688 75627,233863,269252,66596 Snapc1,Gtf3c1,Gtf3c4,Gtf3a R-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.910480438889401 -0.0937828639668379 22 2 0.00134770889487871 1484 8688 15107,52538 Hadh,Acaa2 R-MMU-2151201 Transcriptional activation of mitochondrial biogenesis 0.912562737533412 -0.0914984424276278 13 1 0.000673854447439353 1484 8688 19017 Ppargc1a R-MMU-977441 GABA A receptor activation 0.912562737533412 -0.0914984424276278 13 1 0.000673854447439353 1484 8688 14407 Gabrg3 R-MMU-5696398 Nucleotide Excision Repair 0.914560674771284 -0.0893114658712124 103 13 0.00876010781671159 1484 8688 16881,19359,108679,70620,68142,68275,19687,12572,67967,22190,56469,225280,67439 Lig1,Rad23b,Cops8,Ube2v2,Ino80,Rpa1,Rfc1,Cdk7,Pold3,Ubc,Pias1,Ino80c,Xab2 R-MMU-69206 G1/S Transition 0.915577008973817 -0.0882008015577706 110 14 0.00943396226415094 1484 8688 22390,12534,18968,17217,66413,19076,68275,13555,12572,22190,17463,19167,12544,66997 Wee1,Cdk1,Pola1,Mcm4,Psmd6,Prim2,Rpa1,E2f1,Cdk7,Ubc,Psmd7,Psma3,Cdc45,Psmd12 R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.915695072723271 -0.0880718597682932 61 7 0.00471698113207547 1484 8688 12572,19687,67439,68275,22190,16881,67967 Cdk7,Rfc1,Xab2,Rpa1,Ubc,Lig1,Pold3 R-MMU-69541 Stabilization of p53 0.918377199658429 -0.0851470798809013 54 6 0.00404312668463612 1484 8688 66413,22190,17463,66997,103554,19167 Psmd6,Ubc,Psmd7,Psmd12,Psme4,Psma3 R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.918773280218291 -0.0847158897630123 151 20 0.0134770889487871 1484 8688 19155,66663,17463,22190,50754,218215,380928,67845,19647,66413,230904,244421,66997,103554,20437,83814,218203,74244,387524,19167 Npepps,Uba5,Psmd7,Ubc,Fbxw7,Rnf144b,Lmo7,Rnf115,Rbbp6,Psmd6,Fbxo2,Lonrf1,Psmd12,Psme4,Siah1a,Nedd4l,Mylip,Atg7,Znrf2,Psma3 R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.918803825493268 -0.0846826446002541 31 3 0.00202156334231806 1484 8688 16008,18491,16009 Igfbp2,Pappa,Igfbp3 R-MMU-429914 Deadenylation-dependent mRNA decay 0.919558373564926 -0.0838617529235034 39 4 0.00269541778975741 1484 8688 67678,72587,68106,70640 Lsm3,Pan3,Nt5c3b,Dcp2 R-MMU-5578749 Transcriptional regulation by small RNAs 0.920621993158092 -0.0827057578581884 76 9 0.00606469002695418 1484 8688 15081,72787,54563,218210,69482,97114,319161,97122,227720 H3f3b,Ndc1,Nup210,Nup153,Nup35,Hist2h3c2,Hist1h4n,Hist2h4,Nup214 R-MMU-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 0.92171728391528 -0.081516735944734 69 8 0.00539083557951483 1484 8688 17463,22190,112407,103554,66997,19167,66413,216080 Psmd7,Ubc,Egln3,Psme4,Psmd12,Psma3,Psmd6,Ube2d1 R-MMU-2262749 Cellular response to hypoxia 0.92171728391528 -0.081516735944734 69 8 0.00539083557951483 1484 8688 17463,22190,112407,66997,103554,19167,66413,216080 Psmd7,Ubc,Egln3,Psmd12,Psme4,Psma3,Psmd6,Ube2d1 R-MMU-1442490 Collagen degradation 0.922519111510981 -0.0806471861969763 47 5 0.00336927223719677 1484 8688 77018,18550,12819,17388,218275 Col25a1,Furin,Col15a1,Mmp15,BC051665 R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.922519111510981 -0.0806471861969763 47 5 0.00336927223719677 1484 8688 103554,66997,19167,17463,66413 Psme4,Psmd12,Psma3,Psmd7,Psmd6 R-MMU-933541 TRAF6 mediated IRF7 activation 0.923037146538245 -0.0800857998522254 23 2 0.00134770889487871 1484 8688 72162,16363 Dhx36,Irf2 R-MMU-453279 Mitotic G1-G1/S phases 0.924877209022949 -0.0780942972835919 132 17 0.011455525606469 1484 8688 22190,17463,12571,17217,12534,12572,71978,13555,66997,21973,19167,12544,66413,18968,22390,68275,19076 Ubc,Psmd7,Cdk6,Mcm4,Cdk1,Cdk7,Ppp2r2a,E2f1,Psmd12,Top2a,Psma3,Cdc45,Psmd6,Pola1,Wee1,Rpa1,Prim2 R-MMU-72187 mRNA 3'-end processing 0.926469921231273 -0.0763736987256812 55 6 0.00404312668463612 1484 8688 66118,228410,66231,269061,51796,18789 Sarnp,Cstf3,Thoc7,Cpsf7,Srrm1,Papola R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.926469921231273 -0.0763736987256812 55 6 0.00404312668463612 1484 8688 66413,17463,22190,19167,103554,66997 Psmd6,Psmd7,Ubc,Psma3,Psme4,Psmd12 R-MMU-211000 Gene Silencing by RNA 0.926855067016292 -0.0759580719003751 105 13 0.00876010781671159 1484 8688 14000,319161,69482,97114,227720,97122,213988,54563,15081,83561,72787,83456,218210 Drosha,Hist1h4n,Nup35,Hist2h3c2,Nup214,Hist2h4,Tnrc6b,Nup210,H3f3b,Tdrd1,Ndc1,Mov10l1,Nup153 R-MMU-391903 Eicosanoid ligand-binding receptors 0.927520304964647 -0.075240592595004 14 1 0.000673854447439353 1484 8688 19220 Ptgfr R-MMU-74217 Purine salvage 0.927520304964647 -0.075240592595004 14 1 0.000673854447439353 1484 8688 11534 Adk R-MMU-8854518 AURKA Activation by TPX2 0.928766564602639 -0.0738978477362541 70 8 0.00539083557951483 1484 8688 214444,214552,12534,18005,13589,26920,18536,381644 Cdk5rap2,Cep164,Cdk1,Nek2,Mapre1,Cntrl,Pcm1,Cep135 R-MMU-1222556 ROS, RNS production in phagocytes 0.928928836557505 -0.073723145300992 32 3 0.00202156334231806 1484 8688 66335,338375,11974 Atp6v1c1,Atp6v1g3,Atp6v0e R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 0.933919384967949 -0.0683651560758393 24 2 0.00134770889487871 1484 8688 65969,93835 Cubn,Amn R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.93692034839534 -0.0651570074057489 41 4 0.00269541778975741 1484 8688 52504,97122,319161,66311 Cenpo,Hist2h4,Hist1h4n,Cenpw R-MMU-774815 Nucleosome assembly 0.93692034839534 -0.0651570074057489 41 4 0.00269541778975741 1484 8688 52504,97122,319161,66311 Cenpo,Hist2h4,Hist1h4n,Cenpw R-MMU-73856 RNA Polymerase II Transcription Termination 0.937447286655113 -0.06459475028628 64 7 0.00471698113207547 1484 8688 66231,20643,269061,66118,228410,51796,18789 Thoc7,Snrpe,Cpsf7,Sarnp,Cstf3,Srrm1,Papola R-MMU-109688 Cleavage of Growing Transcript in the Termination Region 0.937447286655113 -0.06459475028628 64 7 0.00471698113207547 1484 8688 51796,18789,228410,66118,20643,66231,269061 Srrm1,Papola,Cstf3,Sarnp,Snrpe,Thoc7,Cpsf7 R-MMU-5620912 Anchoring of the basal body to the plasma membrane 0.9379229140127 -0.064087514576108 93 11 0.00741239892183288 1484 8688 214552,382090,214444,26920,18536,381644,18005,13589,12534,52906,260305 Cep164,Cep162,Cdk5rap2,Cntrl,Pcm1,Cep135,Nek2,Mapre1,Cdk1,Ahi1,Nphp4 R-MMU-194002 Glucocorticoid biosynthesis 0.939920566375585 -0.0619599111445004 15 1 0.000673854447439353 1484 8688 18976 Pomc R-MMU-2142753 Arachidonic acid metabolism 0.941225187377224 -0.0605728615677187 72 8 0.00539083557951483 1484 8688 17001,19224,66469,18783,18979,622402,21391,230639 Ltc4s,Ptgs1,Prxl2b,Pla2g4a,Pon1,Akr1c12,Tbxas1,Cyp4a29 R-MMU-6807505 RNA polymerase II transcribes snRNA genes 0.941225187377224 -0.0605728615677187 72 8 0.00539083557951483 1484 8688 68705,12572,75627,70885,13716,83602,68153,109019 Gtf2f2,Cdk7,Snapc1,Ints10,Ell,Gtf2a1,Gtf2e2,Nabp1 R-MMU-5610787 Hedgehog 'off' state 0.943057686132256 -0.0586278252268221 94 11 0.00741239892183288 1484 8688 19167,18222,14633,103554,66997,16576,17463,22190,14634,74682,66413 Psma3,Numb,Gli2,Psme4,Psmd12,Kif7,Psmd7,Ubc,Gli3,Wdr35,Psmd6 R-MMU-73894 DNA Repair 0.943203136702697 -0.058473604167923 269 37 0.0249326145552561 1484 8688 67439,227525,225280,22230,59047,18294,12572,68142,14048,26383,67967,232314,68098,68275,19360,15574,19359,22190,330554,223970,14087,51869,16881,97122,56469,319161,101831,55982,19687,70620,108679,26419,12144,19356,319583,11350,17535 Xab2,Dclre1c,Ino80c,Ufd1,Pnkp,Ogg1,Cdk7,Ino80,Eya1,Fto,Pold3,Ppp4r2,Rchy1,Rpa1,Rad50,Hus1,Rad23b,Ubc,Fan1,Rmi2,Fanca,Rif1,Lig1,Hist2h4,Pias1,Hist1h4n,Faap24,Paxip1,Rfc1,Ube2v2,Cops8,Mapk8,Blm,Rad17,Lig4,Abl1,Mre11a R-MMU-73887 Death Receptor Signalling 0.944258018515752 -0.0573558254841371 42 4 0.00269541778975741 1484 8688 20598,68652,18201,22190 Smpd2,Tab2,Nsmaf,Ubc R-MMU-1852241 Organelle biogenesis and maintenance 0.944662815830417 -0.0569272238048062 276 38 0.0256064690026954 1484 8688 68146,12534,241113,18005,60441,212541,66230,214552,68565,76260,73916,75465,18536,21821,381644,74682,52906,12589,56280,13196,16579,16559,72938,26920,59054,319845,108079,108099,232536,64656,215445,382090,64436,19017,260305,13589,67068,214444 Arl13b,Cdk1,Prkag3,Nek2,Mrpl38,Rho,Mrps28,Cep164,Mrps18a,Ttc8,Ift57,Dynlrb2,Pcm1,Ift88,Cep135,Wdr35,Ahi1,Ift81,Mrpl37,Asap1,Kifap3,Kif17,Hspb11,Cntrl,Mrps30,Bbs9,Prkaa2,Prkag2,Mrps35,Mrps23,Rab11fip3,Cep162,Inpp5e,Ppargc1a,Nphp4,Mapre1,Dynlrb1,Cdk5rap2 R-MMU-5676590 NIK-->noncanonical NF-kB signaling 0.946661433161866 -0.0548137648604184 58 6 0.00404312668463612 1484 8688 17463,22190,66413,19167,103554,66997 Psmd7,Ubc,Psmd6,Psma3,Psme4,Psmd12 R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.946661433161866 -0.0548137648604184 58 6 0.00404312668463612 1484 8688 66413,22190,17463,19167,66997,103554 Psmd6,Ubc,Psmd7,Psma3,Psmd12,Psme4 R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex 0.946661433161866 -0.0548137648604184 58 6 0.00404312668463612 1484 8688 19167,103554,66997,17463,22190,66413 Psma3,Psme4,Psmd12,Psmd7,Ubc,Psmd6 R-MMU-4839726 Chromatin organization 0.946868471486066 -0.0545950851083669 191 25 0.0168463611859838 1484 8688 67956,97122,18600,97114,228829,319161,11569,77035,52690,57376,54343,18599,66083,18505,28019,69726,14013,140858,77683,381022,13435,338523,67155,15081,216850 Kmt5a,Hist2h4,Padi2,Hist2h3c2,Phf20,Hist1h4n,Aebp2,Kdm8,Setd3,Smarce1,Atf7ip,Padi1,Setd6,Pax3,Ing4,Smyd3,Mecom,Wdr5,Ehmt1,Kmt2d,Dnmt3a,Kdm7a,Smarca2,H3f3b,Kdm6b R-MMU-3247509 Chromatin modifying enzymes 0.946868471486066 -0.0545950851083669 191 25 0.0168463611859838 1484 8688 14013,140858,28019,69726,381022,77683,216850,13435,338523,15081,67155,18600,67956,97122,319161,97114,228829,54343,57376,11569,52690,77035,18505,18599,66083 Mecom,Wdr5,Ing4,Smyd3,Kmt2d,Ehmt1,Kdm6b,Dnmt3a,Kdm7a,H3f3b,Smarca2,Padi2,Kmt5a,Hist2h4,Hist1h4n,Hist2h3c2,Phf20,Atf7ip,Smarce1,Aebp2,Setd3,Kdm8,Pax3,Padi1,Setd6 R-MMU-1640170 Cell Cycle 0.94862610458249 -0.0527405468550068 596 88 0.0592991913746631 1484 8688 245474,55948,17463,26417,68999,17217,12572,26920,67967,13000,319168,17120,23856,66977,66997,15574,226747,208628,66654,16319,22190,227720,16881,18005,54563,72415,259279,223970,97114,319161,67956,19167,12544,103554,19356,66413,12144,70620,18536,19687,103768,69482,236930,71782,22630,77805,67121,59126,26931,218210,16905,71978,214444,22629,22194,21973,16906,22390,13589,66311,110379,59021,18751,100710,19076,19360,68275,268930,14245,229776,214552,12571,15081,12534,13555,107995,52504,97122,71521,18968,17535,72787,22367,56430,216080,217718,381644,64009 Dkc1,Sfn,Psmd7,Mapk3,Anapc10,Mcm4,Cdk7,Cntrl,Pold3,Csnk2a2,Hist1h2ah,Mad1l1,Dido1,Nuf2,Psmd12,Hus1,Ahctf1,Kntc1,Tex12,Incenp,Ubc,Nup214,Lig1,Nek2,Nup210,Sgo1,Tubgcp3,Rmi2,Hist2h3c2,Hist1h4n,Kmt5a,Psma3,Cdc45,Psme4,Rad17,Psmd6,Blm,Ube2v2,Pcm1,Rfc1,Tubg2,Nup35,Ercc6l,Ankle2,Ywhaq,Esco1,Mastl,Nek6,Ppp2r5c,Nup153,Lmna,Ppp2r2a,Cdk5rap2,Ywhah,Ube2e1,Top2a,Lmnb1,Wee1,Mapre1,Cenpw,Sec13,Rab2a,Prkcb,Pds5b,Prim2,Rad50,Rpa1,Pkmyt1,Lpin1,Cdc14a,Cep164,Cdk6,H3f3b,Cdk1,E2f1,Cdc20,Cenpo,Hist2h4,Pds5a,Pola1,Mre11a,Ndc1,Vrk1,Clip1,Ube2d1,Nek9,Cep135,Syne1 R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry 0.949043349706888 -0.0523008020615407 66 7 0.00471698113207547 1484 8688 19167,66997,12572,22390,66413,22190,17463 Psma3,Psmd12,Cdk7,Wee1,Psmd6,Ubc,Psmd7 R-MMU-69202 Cyclin E associated events during G1/S transition 0.949043349706888 -0.0523008020615407 66 7 0.00471698113207547 1484 8688 66997,12572,19167,17463,22190,66413,22390 Psmd12,Cdk7,Psma3,Psmd7,Ubc,Psmd6,Wee1 R-MMU-389948 PD-1 signaling 0.950200501762999 -0.0510822621690487 16 1 0.000673854447439353 1484 8688 19247 Ptpn11 R-MMU-429958 mRNA decay by 3' to 5' exoribonuclease 0.950200501762999 -0.0510822621690487 16 1 0.000673854447439353 1484 8688 68106 Nt5c3b R-MMU-912694 Regulation of IFNA signaling 0.951460214868706 -0.0497574061850674 26 2 0.00134770889487871 1484 8688 19247,54721 Ptpn11,Tyk2 R-MMU-6804758 Regulation of TP53 Activity through Acetylation 0.951460214868706 -0.0497574061850674 26 2 0.00134770889487871 1484 8688 23988,69260 Pin1,Ing2 R-MMU-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.951723780561826 -0.0494804327600727 74 8 0.00539083557951483 1484 8688 67439,67967,22190,68275,108679,19687,12572,16881 Xab2,Pold3,Ubc,Rpa1,Cops8,Rfc1,Cdk7,Lig1 R-MMU-69304 Regulation of DNA replication 0.956318915235954 -0.0446638282175751 75 8 0.00539083557951483 1484 8688 19167,66997,103554,22190,17463,13555,66413,17217 Psma3,Psmd12,Psme4,Ubc,Psmd7,E2f1,Psmd6,Mcm4 R-MMU-453274 Mitotic G2-G2/M phases 0.956598288109193 -0.0443717372951485 167 21 0.0141509433962264 1484 8688 259279,13555,12572,26920,71978,12534,18005,214552,17463,22190,381644,103768,268930,18536,22390,13589,66413,19167,66997,103554,214444 Tubgcp3,E2f1,Cdk7,Cntrl,Ppp2r2a,Cdk1,Nek2,Cep164,Psmd7,Ubc,Cep135,Tubg2,Pkmyt1,Pcm1,Wee1,Mapre1,Psmd6,Psma3,Psmd12,Psme4,Cdk5rap2 R-MMU-381119 Unfolded Protein Response (UPR) 0.958722463876568 -0.0421536475719831 17 1 0.000673854447439353 1484 8688 66212 Sec61b R-MMU-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.958722463876568 -0.0421536475719831 17 1 0.000673854447439353 1484 8688 70640 Dcp2 R-MMU-5358346 Hedgehog ligand biogenesis 0.961729802918023 -0.0390217379154226 61 6 0.00404312668463612 1484 8688 66413,22190,17463,103554,66997,19167 Psmd6,Ubc,Psmd7,Psme4,Psmd12,Psma3 R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition 0.962543356713437 -0.0381761678986973 84 9 0.00606469002695418 1484 8688 13589,18005,12534,381644,18536,26920,22190,214444,214552 Mapre1,Nek2,Cdk1,Cep135,Pcm1,Cntrl,Ubc,Cdk5rap2,Cep164 R-MMU-3214847 HATs acetylate histones 0.964351450285806 -0.0362994758276278 77 8 0.00539083557951483 1484 8688 319161,140858,228829,97114,28019,97122,18505,15081 Hist1h4n,Wdr5,Phf20,Hist2h3c2,Ing4,Hist2h4,Pax3,H3f3b R-MMU-6798695 Neutrophil degranulation 0.964367931125942 -0.0362823858970808 561 81 0.0545822102425876 1484 8688 227288,53378,14293,74012,19271,76577,15369,16480,15481,26364,17463,18648,232714,70495,20195,14667,19276,19353,17380,15442,67512,216134,66997,11625,100040563,102595,11758,11674,14590,15289,72461,12509,229574,16592,13505,66413,20868,66612,110095,210992,269116,18772,74244,18405,15511,15926,110173,68682,70152,12306,231507,12331,14190,13367,619326,67653,74287,12491,216197,72065,71902,106572,20716,66713,74096,16498,29875,52588,16004,104009,18641,18753,70536,110078,109754,235661,70450,74039,14134,19261,18600 Cxcr1,Sdcbp,Fpr1,Rap2b,Ptprj,Faf2,Hmox2,Jup,Hspa8,Adgre5,Psmd7,Pgam1,Mgam,Atp6ap2,S100a11,Gm2a,Ptprn2,Rac1,Mme,Hpse,Agpat2,Pdxk,Psmd12,Ahsg,Dynlt1c,Plekho2,Prdx6,Aldoa,Ggh,Hmgb1,Prcp,Cd59a,Flg2,Fabp5,Dsc1,Psmd6,Stk10,Ormdl3,Pygl,Lpcat1,Nfasc,Pkp1,Atg7,Orm1,Hspa1b,Idh1,Manba,Slc44a2,Mettl7a1,Anxa2,Plac8,Cap1,Fgl2,Diaph1,9130409I23Rik,4930544G11Rik,Kcmf1,Cd36,Ckap4,Rap2c,Cand1,Rab31,Serpina3n,Actr2,Hvcn1,Kcnab2,Iqgap1,Tspan14,Igf2r,Qsox1,Pfkl,Prkcd,Qpct,Pygb,Cyb5r3,Dync1li1,Unc13d,Nfam1,Fcnb,Sirpa,Padi2 R-MMU-909733 Interferon alpha/beta signaling 0.964498062837353 -0.0361474551014569 28 2 0.00134770889487871 1484 8688 54721,19247 Tyk2,Ptpn11 R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.964498062837353 -0.0361474551014569 28 2 0.00134770889487871 1484 8688 12572,68705 Cdk7,Gtf2f2 R-MMU-163210 Formation of ATP by chemiosmotic coupling 0.965786915906791 -0.0348120530492578 18 1 0.000673854447439353 1484 8688 28080 Atp5o R-MMU-189445 Metabolism of porphyrins 0.965786915906791 -0.0348120530492578 18 1 0.000673854447439353 1484 8688 15369 Hmox2 R-MMU-180024 DARPP-32 events 0.965786915906791 -0.0348120530492578 18 1 0.000673854447439353 1484 8688 18578 Pde4b R-MMU-69580 p53-Dependent G1/S DNA damage checkpoint 0.965817082305812 -0.034780818490775 62 6 0.00404312668463612 1484 8688 22190,17463,66413,19167,66997,103554 Ubc,Psmd7,Psmd6,Psma3,Psmd12,Psme4 R-MMU-6782135 Dual incision in TC-NER 0.965817082305812 -0.034780818490775 62 6 0.00404312668463612 1484 8688 12572,19687,67439,68275,22190,67967 Cdk7,Rfc1,Xab2,Rpa1,Ubc,Pold3 R-MMU-69563 p53-Dependent G1 DNA Damage Response 0.965817082305812 -0.034780818490775 62 6 0.00404312668463612 1484 8688 19167,66997,103554,66413,17463,22190 Psma3,Psmd12,Psme4,Psmd6,Psmd7,Ubc R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.966441434038724 -0.0341345780945145 46 4 0.00269541778975741 1484 8688 68153,68705,12572,83602 Gtf2e2,Gtf2f2,Cdk7,Gtf2a1 R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.966441434038724 -0.0341345780945145 46 4 0.00269541778975741 1484 8688 68705,12572,83602,68153 Gtf2f2,Cdk7,Gtf2a1,Gtf2e2 R-MMU-75953 RNA Polymerase II Transcription Initiation 0.966441434038724 -0.0341345780945145 46 4 0.00269541778975741 1484 8688 68153,12572,68705,83602 Gtf2e2,Cdk7,Gtf2f2,Gtf2a1 R-MMU-73776 RNA Polymerase II Promoter Escape 0.966441434038724 -0.0341345780945145 46 4 0.00269541778975741 1484 8688 68153,68705,12572,83602 Gtf2e2,Gtf2f2,Cdk7,Gtf2a1 R-MMU-69052 Switching of origins to a post-replicative state 0.966640605639931 -0.0339285117219299 70 7 0.00471698113207547 1484 8688 22190,17217,17463,66413,66997,103554,19167 Ubc,Mcm4,Psmd7,Psmd6,Psmd12,Psme4,Psma3 R-MMU-3214858 RMTs methylate histone arginines 0.966640605639931 -0.0339285117219299 70 7 0.00471698113207547 1484 8688 67155,97114,13435,140858,319161,97122,57376 Smarca2,Hist2h3c2,Dnmt3a,Wdr5,Hist1h4n,Hist2h4,Smarce1 R-MMU-68949 Orc1 removal from chromatin 0.966640605639931 -0.0339285117219299 70 7 0.00471698113207547 1484 8688 22190,17463,17217,66413,19167,66997,103554 Ubc,Psmd7,Mcm4,Psmd6,Psma3,Psmd12,Psme4 R-MMU-72165 mRNA Splicing - Minor Pathway 0.969535347247507 -0.0309383457092749 55 5 0.00336927223719677 1484 8688 67225,20643,22184,81898,68705 Rnpc3,Snrpe,Zrsr2,Sf3b1,Gtf2f2 R-MMU-69275 G2/M Transition 0.969556351529709 -0.0309166816670687 165 20 0.0134770889487871 1484 8688 214552,17463,22190,259279,12572,26920,71978,12534,18005,19167,103554,66997,214444,18536,268930,381644,103768,22390,13589,66413 Cep164,Psmd7,Ubc,Tubgcp3,Cdk7,Cntrl,Ppp2r2a,Cdk1,Nek2,Psma3,Psme4,Psmd12,Cdk5rap2,Pcm1,Pkmyt1,Cep135,Tubg2,Wee1,Mapre1,Psmd6 R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.969682238920381 -0.0307868498954971 29 2 0.00134770889487871 1484 8688 233863,269252 Gtf3c1,Gtf3c4 R-MMU-5619507 Activation of HOX genes during differentiation 0.972330894484711 -0.0280591060290261 131 15 0.0101078167115903 1484 8688 55982,381022,19411,17268,218772,15081,16476,19401,20181,22658,97122,319161,140858,319168,97114 Paxip1,Kmt2d,Rarg,Meis1,Rarb,H3f3b,Jun,Rara,Rxra,Pcgf2,Hist2h4,Hist1h4n,Wdr5,Hist1h2ah,Hist2h3c2 R-MMU-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0.972330894484711 -0.0280591060290261 131 15 0.0101078167115903 1484 8688 97122,19401,22658,20181,16476,97114,319161,140858,319168,218772,55982,381022,17268,19411,15081 Hist2h4,Rara,Pcgf2,Rxra,Jun,Hist2h3c2,Hist1h4n,Wdr5,Hist1h2ah,Rarb,Paxip1,Kmt2d,Meis1,Rarg,H3f3b R-MMU-69615 G1/S DNA Damage Checkpoints 0.972817054255029 -0.0275592368229273 64 6 0.00404312668463612 1484 8688 19167,66997,103554,17463,22190,66413 Psma3,Psmd12,Psme4,Psmd7,Ubc,Psmd6 R-MMU-166658 Complement cascade 0.973034043490324 -0.0273362092372644 39 3 0.00202156334231806 1484 8688 12509,12279,110382 Cd59a,C9,C8b R-MMU-69300 Removal of licensing factors from origins 0.973179819498593 -0.0271864045202047 72 7 0.00471698113207547 1484 8688 66413,17463,17217,22190,66997,103554,19167 Psmd6,Psmd7,Mcm4,Ubc,Psmd12,Psme4,Psma3 R-MMU-73854 RNA Polymerase I Promoter Clearance 0.973915891140592 -0.0264303331334296 80 8 0.00539083557951483 1484 8688 12572,18519,15081,17191,97122,26417,319161,97114 Cdk7,Kat2b,H3f3b,Mbd2,Hist2h4,Mapk3,Hist1h4n,Hist2h3c2 R-MMU-72086 mRNA Capping 0.974132596599477 -0.0262078484661919 30 2 0.00134770889487871 1484 8688 12572,68705 Cdk7,Gtf2f2 R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.974144091351117 -0.026196048549156 48 4 0.00269541778975741 1484 8688 56347,20090,267019,98221 Eif3c,Rps29,Rps15a,Eif3m R-MMU-73864 RNA Polymerase I Transcription 0.976540815306447 -0.0237387319900513 81 8 0.00539083557951483 1484 8688 12572,18519,15081,17191,97122,26417,319161,97114 Cdk7,Kat2b,H3f3b,Mbd2,Hist2h4,Mapk3,Hist1h4n,Hist2h3c2 R-MMU-168256 Immune System 0.976944694613167 -0.0233252358976329 1698 263 0.17722371967655 1484 8688 70450,235661,16363,19261,15461,17079,19247,16154,67245,230904,70536,12803,13874,13690,58181,71902,20742,19155,16412,20716,18035,56489,66713,72049,216197,13367,12279,18575,231474,12306,68682,18803,11765,14573,381925,16155,69807,109270,16590,218203,16176,16337,14186,17084,15289,22190,67665,26395,208650,102595,110651,14590,216238,66997,16160,12519,14667,18648,66397,18383,20111,384783,93694,16579,20437,11867,18018,18753,17973,11974,26419,18710,16163,74096,16169,106572,101568,22034,19419,21897,20848,108058,67653,55991,26410,13800,14173,76089,23988,107607,13645,231507,97114,11876,19167,18772,20203,16182,20868,67845,24099,66612,19056,16592,12487,100040563,14585,11758,16177,244421,54721,20851,67512,23980,11625,20908,22031,18673,19647,19276,21940,20112,17463,107746,232714,14183,72162,12048,16196,15369,14134,12314,14184,18641,110078,109754,216080,29875,218215,52588,16004,16591,66335,22194,319520,619326,14083,18479,338375,110379,18751,54167,12491,11793,74287,21936,12331,69601,74117,70152,67603,18708,15511,18405,387524,74244,103554,110173,15926,240354,11350,66413,58194,19091,110095,11674,245527,12986,213208,14811,17380,286940,209737,668303,20195,70495,21682,26364,16452,17096,227288,99571,74012,14293,53378,227743,76577,140580,16367,74039,19258,56469,18600,64291,17535,104009,16706,16498,20404,72065,110157,19055,16880,94212,14178,11820,26420,66663,14190,50754,21943,57257,13869,26931,218275,269116,210992,12043,19417,66589,13429,72461,16190,99683,12509,13505,229574,68652,11768,235584,19353,17909,15442,83814,16476,216134,14176,13426,53357,252903,17087,15481,16439,19200,110382,26417,380928,110351,73086,240672,19271,93834,16480 Unc13d,Dync1li1,Irf2,Sirpa,Hras,Cd180,Ptpn11,Il10ra,Peli1,Fbxo2,Qpct,Cntf,Ereg,Eif4g2,Il20,Cand1,Sptbn1,Npepps,Itgb1,Serpina3n,Nfkbia,Ikbke,Actr2,Tnfrsf13c,Ckap4,Diaph1,C9,Pde1c,Paqr3,Anxa2,Slc44a2,Plcg1,Ap1g1,Gdnf,Plpp4,Il10rb,Trim32,Prr5,Kit,Mylip,Il1b,Insr,Fgfr4,Ly86,Hmgb1,Ubc,Dctn4,Map2k1,Cblb,Plekho2,Rps6ka3,Ggh,Eea1,Psmd12,Il12b,Cd80,Gm2a,Pgam1,Sar1b,Tnfrsf11b,Rps6ka1,Irs2,Clec2d,Kifap3,Siah1a,Arpc1b,Nfatc1,Prkcd,Nck1,Atp6v0e,Mapk8,Pik3r3,Il13,Hvcn1,Il15ra,Rab31,Vrk3,Traf6,Rasgrp1,Tlr1,Stat3,Camk2d,4930544G11Rik,Panx1,Map3k8,Enah,Fgf2,Rapgef2,Pin1,Nod1,Egf,Plac8,Hist2h3c2,Artn,Psma3,Pkp1,S100b,Il18r1,Stk10,Rnf115,Tnfsf13b,Ormdl3,Ppp3cb,Fabp5,Cd28,Dynlt1c,Gfra1,Prdx6,Il1r1,Lonrf1,Tyk2,Stat5b,Agpat2,Pebp1,Ahsg,Stx3,Traf3,Phb,Rbbp6,Ptprn2,Cd27,Rps6ka2,Psmd7,Rapgef1,Mgam,Fgfr2,Dhx36,Bcl2l1,Il7,Hmox2,Fcnb,Calm2,Fgfr3,Pfkl,Pygb,Cyb5r3,Ube2d1,Iqgap1,Rnf144b,Tspan14,Igf2r,Kl,Atp6v1c1,Ube2e1,Dusp4,9130409I23Rik,Ptk2,Pak1,Atp6v1g3,Sec13,Prkcb,Icos,Cd36,Atg5,Kcmf1,Tnfrsf18,Cap1,Dab2ip,Actr3,Mettl7a1,Dusp6,Pik3r1,Hspa1b,Orm1,Znrf2,Atg7,Psme4,Manba,Idh1,Malt1,Abl1,Psmd6,Sh3kbp1,Prkg1,Pygl,Aldoa,Eda2r,Csf3r,Il20rb,Grin2a,Mme,Flnb,Kif15,Kif26a,S100a11,Atp6ap2,Tec,Adgre5,Jak2,Lyn,Cxcr1,Fgg,Rap2b,Fpr1,Sdcbp,Mapkap1,Faf2,Elmo1,Irs1,Nfam1,Ptpn4,Pias1,Padi2,Osbpl1a,Mre11a,Qsox1,Ksr1,Kcnab2,Sh3gl2,Rap2c,Raf1,Ppp3ca,Lifr,Pag1,Fgf7,App,Mapk9,Uba5,Fgl2,Fbxw7,Tnfsf11,Vav3,Erbb4,Ppp2r5c,BC051665,Nfasc,Lpcat1,Bcl2,Rasgrf1,Ube2v1,Dnm1,Prcp,Il4ra,Sec24b,Cd59a,Dsc1,Flg2,Tab2,Ap1m2,Dusp7,Rac1,Myo10,Hpse,Nedd4l,Jun,Pdxk,Fgf5,Dync1i1,Pla2g6,Ap1s3,Ly96,Hspa8,Itpr2,Pstpip1,C8b,Mapk3,Lmo7,Rap1gap,Rps6ka5,Dusp5,Ptprj,Peli2,Jup R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA 0.977331360013233 -0.0229295237317935 231 29 0.0195417789757412 1484 8688 228410,23983,269061,19205,72787,67225,81898,68705,20643,66231,69482,15481,67678,56488,227720,71702,67439,53379,66118,15387,66642,80744,54563,18789,229279,22184,218210,74326,51796 Cstf3,Pcbp1,Cpsf7,Ptbp1,Ndc1,Rnpc3,Sf3b1,Gtf2f2,Snrpe,Thoc7,Nup35,Hspa8,Lsm3,Nxt1,Nup214,Cdc5l,Xab2,Hnrnpa2b1,Sarnp,Hnrnpk,Ctnnbl1,Cwc22,Nup210,Papola,Hnrnpa3,Zrsr2,Nup153,Hnrnpr,Srrm1 R-MMU-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.977948373908394 -0.0222983977553545 31 2 0.00134770889487871 1484 8688 83561,83456 Tdrd1,Mov10l1 R-MMU-112382 Formation of RNA Pol II elongation complex 0.978938986844868 -0.0212859603090723 58 5 0.00336927223719677 1484 8688 74427,13716,68705,70122,12572 Eaf1,Ell,Gtf2f2,Mllt3,Cdk7 R-MMU-75955 RNA Polymerase II Transcription Elongation 0.978938986844868 -0.0212859603090723 58 5 0.00336927223719677 1484 8688 74427,13716,68705,70122,12572 Eaf1,Ell,Gtf2f2,Mllt3,Cdk7 R-MMU-1280218 Adaptive Immune System 0.979882557993916 -0.0203225532804785 606 86 0.0579514824797844 1484 8688 22034,19419,18751,18479,54167,110379,94212,12491,26410,50754,14178,66663,13645,26931,13869,13800,14173,18803,11765,15461,14184,16579,20437,19247,235661,16367,93694,230904,17973,216080,64291,218215,13874,20404,110157,16591,18035,16412,19155,83814,66997,668303,209737,19353,244421,13426,12519,14176,252903,19647,66397,26417,380928,14183,17096,16439,17463,227743,384783,110351,19271,387524,74244,19167,218203,16590,103554,218275,109270,18708,13429,14186,58194,19091,16337,66589,66413,240354,67845,12487,99683,22190,67665,68652,208650,11768 Traf6,Rasgrp1,Prkcb,Pak1,Icos,Sec13,Pag1,Cd36,Map3k8,Fbxw7,Fgf7,Uba5,Egf,Ppp2r5c,Erbb4,Enah,Fgf2,Plcg1,Ap1g1,Hras,Fgfr3,Kifap3,Siah1a,Ptpn11,Dync1li1,Irs1,Clec2d,Fbxo2,Nck1,Ube2d1,Osbpl1a,Rnf144b,Ereg,Sh3gl2,Raf1,Kl,Nfkbia,Itgb1,Npepps,Nedd4l,Psmd12,Kif26a,Kif15,Rac1,Lonrf1,Dync1i1,Cd80,Fgf5,Ap1s3,Rbbp6,Sar1b,Mapk3,Lmo7,Fgfr2,Lyn,Itpr2,Psmd7,Mapkap1,Irs2,Rap1gap,Ptprj,Znrf2,Atg7,Psma3,Mylip,Kit,Psme4,BC051665,Prr5,Pik3r1,Dnm1,Fgfr4,Sh3kbp1,Prkg1,Insr,Ube2v1,Psmd6,Malt1,Rnf115,Cd28,Sec24b,Ubc,Dctn4,Tab2,Cblb,Ap1m2 R-MMU-5357956 TNFR1-induced NFkappaB signaling pathway 0.980521050557245 -0.0196711643694192 21 1 0.000673854447439353 1484 8688 68652 Tab2 R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 0.981415455513207 -0.0187594070162581 59 5 0.00336927223719677 1484 8688 17463,22190,66413,66997,19167 Psmd7,Ubc,Psmd6,Psmd12,Psma3 R-MMU-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.982120127391405 -0.0180416487901423 114 12 0.00808625336927224 1484 8688 75627,233863,12572,15081,18519,66596,26417,97122,17191,97114,269252,319161 Snapc1,Gtf3c1,Cdk7,H3f3b,Kat2b,Gtf3a,Mapk3,Hist2h4,Mbd2,Hist2h3c2,Gtf3c4,Hist1h4n R-MMU-72172 mRNA Splicing 0.983517061259329 -0.016620293810526 180 21 0.0141509433962264 1484 8688 269061,19205,67225,81898,68705,228410,23983,53379,66642,15387,80744,18789,229279,22184,51796,74326,20643,15481,67678,71702,67439 Cpsf7,Ptbp1,Rnpc3,Sf3b1,Gtf2f2,Cstf3,Pcbp1,Hnrnpa2b1,Ctnnbl1,Hnrnpk,Cwc22,Papola,Hnrnpa3,Zrsr2,Srrm1,Hnrnpr,Snrpe,Hspa8,Lsm3,Cdc5l,Xab2 R-MMU-975298 Ligand-gated ion channel transport 0.983856317773038 -0.0162754111149611 22 1 0.000673854447439353 1484 8688 14407 Gabrg3 R-MMU-1679131 Trafficking and processing of endosomal TLR 0.983856317773038 -0.0162754111149611 22 1 0.000673854447439353 1484 8688 218275 BC051665 R-MMU-5334118 DNA methylation 0.986382358277161 -0.0137112122502119 78 7 0.00471698113207547 1484 8688 319161,319168,97114,13435,15081,13433,97122 Hist1h4n,Hist1h2ah,Hist2h3c2,Dnmt3a,H3f3b,Dnmt1,Hist2h4 R-MMU-113418 Formation of the Early Elongation Complex 0.986401676223016 -0.0136916277994886 34 2 0.00134770889487871 1484 8688 68705,12572 Gtf2f2,Cdk7 R-MMU-5689901 Metalloprotease DUBs 0.986401676223016 -0.0136916277994886 34 2 0.00134770889487871 1484 8688 22190,18519 Ubc,Kat2b R-MMU-5689603 UCH proteinases 0.98658186457704 -0.0135089720896977 94 9 0.00606469002695418 1484 8688 17425,22190,17463,103554,225280,66997,19167,66413,68142 Foxk1,Ubc,Psmd7,Psme4,Ino80c,Psmd12,Psma3,Psmd6,Ino80 R-MMU-674695 RNA Polymerase II Pre-transcription Events 0.987875440492165 -0.012198661558411 79 7 0.00471698113207547 1484 8688 83602,12572,70122,68705,13716,74427,68153 Gtf2a1,Cdk7,Mllt3,Gtf2f2,Ell,Eaf1,Gtf2e2 R-MMU-6781823 Formation of TC-NER Pre-Incision Complex 0.988459797958489 -0.0116073069420635 54 4 0.00269541778975741 1484 8688 22190,12572,67439,108679 Ubc,Cdk7,Xab2,Cops8 R-MMU-72649 Translation initiation complex formation 0.988459797958489 -0.0116073069420635 54 4 0.00269541778975741 1484 8688 20090,56347,267019,98221 Rps29,Eif3c,Rps15a,Eif3m R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.988728179841013 -0.0113358285725959 45 3 0.00202156334231806 1484 8688 13716,12572,68705 Ell,Cdk7,Gtf2f2 R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.989112348182347 -0.0109473560534804 88 8 0.00539083557951483 1484 8688 14852,57808,20090,267019,100502825,11837,225363,56040 Gspt1,Rpl35a,Rps29,Rps15a,Rpl37rt,Rplp0,Etf1,Rplp1 R-MMU-72163 mRNA Splicing - Major Pathway 0.989282049695625 -0.0107758012675623 171 19 0.0128032345013477 1484 8688 228410,23983,19205,269061,68705,81898,67678,20643,15481,71702,67439,80744,15387,66642,53379,51796,74326,229279,18789 Cstf3,Pcbp1,Ptbp1,Cpsf7,Gtf2f2,Sf3b1,Lsm3,Snrpe,Hspa8,Cdc5l,Xab2,Cwc22,Hnrnpk,Ctnnbl1,Hnrnpa2b1,Srrm1,Hnrnpr,Hnrnpa3,Papola R-MMU-72702 Ribosomal scanning and start codon recognition 0.989944068611921 -0.0101068338010757 55 4 0.00269541778975741 1484 8688 98221,267019,20090,56347 Eif3m,Rps15a,Rps29,Eif3c R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.989944068611921 -0.0101068338010757 55 4 0.00269541778975741 1484 8688 56347,20090,267019,98221 Eif3c,Rps29,Rps15a,Eif3m R-MMU-5358351 Signaling by Hedgehog 0.990849719734066 -0.00919240122300337 136 14 0.00943396226415094 1484 8688 66413,74682,117606,14634,75788,17463,22190,16576,103554,66997,57810,14633,18222,19167 Psmd6,Wdr35,Boc,Gli3,Smurf1,Psmd7,Ubc,Kif7,Psme4,Psmd12,Cdon,Gli2,Numb,Psma3 R-MMU-1221633 Meiotic Synapsis 0.991410759762878 -0.00862634035502381 106 10 0.00673854447439353 1484 8688 23856,97122,319168,319161,97114,66654,64009,16905,15081,16906 Dido1,Hist2h4,Hist1h2ah,Hist1h4n,Hist2h3c2,Tex12,Syne1,Lmna,H3f3b,Lmnb1 R-MMU-1221632 Meiotic synapsis 0.991410759762878 -0.00862634035502381 106 10 0.00673854447439353 1484 8688 16906,15081,64009,66654,16905,319161,319168,97114,23856,97122 Lmnb1,H3f3b,Syne1,Tex12,Lmna,Hist1h4n,Hist1h2ah,Hist2h3c2,Dido1,Hist2h4 R-MMU-5389840 Mitochondrial translation elongation 0.992443997447177 -0.00758469375870106 83 7 0.00471698113207547 1484 8688 56280,60441,64656,59054,68565,66230,232536 Mrpl37,Mrpl38,Mrps23,Mrps30,Mrps18a,Mrps28,Mrps35 R-MMU-212165 Epigenetic regulation of gene expression 0.992445391404337 -0.00758328918959231 138 14 0.00943396226415094 1484 8688 13433,97114,214133,319168,319161,97122,17191,15081,13435,18519,110052,81898,17913,11569 Dnmt1,Hist2h3c2,Tet2,Hist1h2ah,Hist1h4n,Hist2h4,Mbd2,H3f3b,Dnmt3a,Kat2b,Dek,Sf3b1,Myo1c,Aebp2 R-MMU-1500620 Meiosis 0.992626642104911 -0.00740067546271673 123 12 0.00808625336927224 1484 8688 66654,64009,16905,68275,12144,15081,16906,97122,23856,319168,319161,97114 Tex12,Syne1,Lmna,Rpa1,Blm,H3f3b,Lmnb1,Hist2h4,Dido1,Hist1h2ah,Hist1h4n,Hist2h3c2 R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.993071056621043 -0.00695305997337273 108 10 0.00673854447439353 1484 8688 267019,100502825,226517,225363,11837,56040,71978,14852,57808,20090 Rps15a,Rpl37rt,Smg7,Etf1,Rplp0,Rplp1,Ppp2r2a,Gspt1,Rpl35a,Rps29 R-MMU-927802 Nonsense-Mediated Decay (NMD) 0.993071056621043 -0.00695305997337273 108 10 0.00673854447439353 1484 8688 14852,71978,57808,20090,100502825,226517,267019,56040,225363,11837 Gspt1,Ppp2r2a,Rpl35a,Rps29,Rpl37rt,Smg7,Rps15a,Rplp1,Etf1,Rplp0 R-MMU-6799198 Complex I biogenesis 0.993379476483646 -0.0066425363938114 58 4 0.00269541778975741 1484 8688 17993,69487,76947,68375 Ndufs4,Ndufaf5,Ndufaf6,Ndufa8 R-MMU-5357905 Regulation of TNFR1 signaling 0.993689953064155 -0.00633003942876428 27 1 0.000673854447439353 1484 8688 22190 Ubc R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.993689953064155 -0.00633003942876428 27 1 0.000673854447439353 1484 8688 230639 Cyp4a29 R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.993803696011052 -0.00621558075155139 49 3 0.00202156334231806 1484 8688 110379,66397,99683 Sec13,Sar1b,Sec24b R-MMU-5419276 Mitochondrial translation termination 0.994063492765612 -0.00595419834380658 85 7 0.00471698113207547 1484 8688 64656,68565,66230,232536,59054,56280,60441 Mrps23,Mrps18a,Mrps28,Mrps35,Mrps30,Mrpl37,Mrpl38 R-MMU-983169 Class I MHC mediated antigen processing & presentation 0.994481433814147 -0.00553384972698378 215 24 0.0161725067385445 1484 8688 19155,50754,218215,380928,66397,17463,22190,66663,99683,12491,230904,110379,67845,19647,66413,103554,66997,20437,83814,218203,387524,19167,74244,244421 Npepps,Fbxw7,Rnf144b,Lmo7,Sar1b,Psmd7,Ubc,Uba5,Sec24b,Cd36,Fbxo2,Sec13,Rnf115,Rbbp6,Psmd6,Psme4,Psmd12,Siah1a,Nedd4l,Mylip,Znrf2,Psma3,Atg7,Lonrf1 R-MMU-5368287 Mitochondrial translation 0.994743987844043 -0.00526987357972394 86 7 0.00471698113207547 1484 8688 232536,59054,68565,66230,64656,60441,56280 Mrps35,Mrps30,Mrps18a,Mrps28,Mrps23,Mrpl38,Mrpl37 R-MMU-72689 Formation of a pool of free 40S subunits 0.995145068492843 -0.00486675497072015 95 8 0.00539083557951483 1484 8688 56347,20090,57808,98221,267019,100502825,11837,56040 Eif3c,Rps29,Rpl35a,Eif3m,Rps15a,Rpl37rt,Rplp0,Rplp1 R-MMU-73857 RNA Polymerase II Transcription 0.995373327106787 -0.00463740907223501 143 14 0.00943396226415094 1484 8688 20643,66231,228410,68153,83602,13716,269061,66118,74427,18789,51796,12572,68705,70122 Snrpe,Thoc7,Cstf3,Gtf2e2,Gtf2a1,Ell,Cpsf7,Sarnp,Eaf1,Papola,Srrm1,Cdk7,Gtf2f2,Mllt3 R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.996409737537614 -0.00359672292246045 30 1 0.000673854447439353 1484 8688 75627 Snapc1 R-MMU-211897 Cytochrome P450 - arranged by substrate type 0.996988447824121 -0.00301609602411688 99 8 0.00539083557951483 1484 8688 18976,13120,21391,230639,232174,14149,14148,20181 Pomc,Cyp4b1,Tbxas1,Cyp4a29,Cyp26b1,Fdxr,Fdx1,Rxra R-MMU-73777 RNA Polymerase I Chain Elongation 0.997025116316636 -0.00297931744529589 31 1 0.000673854447439353 1484 8688 12572 Cdk7 R-MMU-390522 Striated Muscle Contraction 0.997025116316636 -0.00297931744529589 31 1 0.000673854447439353 1484 8688 13346 Des R-MMU-8854214 TBC/RABGAPs 0.997025116316636 -0.00297931744529589 31 1 0.000673854447439353 1484 8688 381605 Tbc1d2 R-MMU-912497 Meiotic Recombination 0.997171229593092 -0.00283277893917803 91 7 0.00471698113207547 1484 8688 97122,68275,319168,12144,319161,15081,97114 Hist2h4,Rpa1,Hist1h2ah,Blm,Hist1h4n,H3f3b,Hist2h3c2 R-MMU-5250913 Positive epigenetic regulation of rRNA expression 0.997214689673769 -0.00278919652088707 108 9 0.00606469002695418 1484 8688 110052,17913,81898,15081,18519,97122,97114,319168,319161 Dek,Myo1c,Sf3b1,H3f3b,Kat2b,Hist2h4,Hist2h3c2,Hist1h2ah,Hist1h4n R-MMU-211859 Biological oxidations 0.997347535045277 -0.00265598897282641 231 25 0.0168463611859838 1484 8688 69065,17161,18976,109754,13521,242585,71670,14629,232174,14149,14148,18113,23971,19224,108652,13120,23972,211666,216558,21391,232087,14630,230639,228608,20181 Chac1,Maoa,Pomc,Cyb5r3,Slc26a2,Slc35d1,Acy3,Gclc,Cyp26b1,Fdxr,Fdx1,Nnmt,Papss1,Ptgs1,Slc35b3,Cyp4b1,Papss2,Mgst2,Ugp2,Tbxas1,Mat2a,Gclm,Cyp4a29,Smox,Rxra R-MMU-611105 Respiratory electron transport 0.997433624820307 -0.00256967396563139 74 5 0.00336927223719677 1484 8688 68375,110842,76947,17993,69487 Ndufa8,Etfa,Ndufaf6,Ndufs4,Ndufaf5 R-MMU-427413 NoRC negatively regulates rRNA expression 0.997506032804307 -0.00249708231229017 92 7 0.00471698113207547 1484 8688 17191,97122,319161,319168,97114,13433,15081 Mbd2,Hist2h4,Hist1h4n,Hist1h2ah,Hist2h3c2,Dnmt1,H3f3b R-MMU-1170546 Prolactin receptor signaling 0.997535076748052 -0.00246796617667906 32 1 0.000673854447439353 1484 8688 16452 Jak2 R-MMU-73772 RNA Polymerase I Promoter Escape 0.997535076748052 -0.00246796617667906 32 1 0.000673854447439353 1484 8688 12572 Cdk7 R-MMU-74160 Gene Expression 0.997635073087445 -0.00236772776895764 1163 166 0.111859838274933 1484 8688 26381,15081,12534,103806,75627,18667,94093,13433,14782,56488,15258,17535,20090,19205,72787,269061,270118,18753,21679,68153,97122,53379,108079,19042,23988,80744,26931,228839,71978,68106,19883,98221,70885,68275,11569,68705,214133,56222,54170,23983,213988,54563,241113,12450,77976,226517,83602,12795,11835,13716,12144,19356,69260,97114,18129,319161,67381,67956,19167,20602,72587,51796,12572,74326,20643,15481,17463,19401,26417,22337,15574,216154,14000,319168,100502825,83814,83561,66642,15387,17126,18789,16009,67678,109019,19016,18124,12729,21834,81898,641340,110052,216080,26380,74370,231464,23958,17127,66118,22630,218210,77683,18128,56040,69482,80707,20181,71702,18519,66596,19360,22061,22629,68979,267019,56347,74427,57808,56187,12393,229279,218772,14852,22184,223970,66231,22190,57316,225363,227720,234374,68975,67225,66413,215193,70640,233863,19411,21676,109270,15511,217109,106931,24127,17131,17191,103554,269536,13435,21388,14815,11737,83456,227743,17913,70122,55948,11837,108099,67439,21815,13000,20393,228410,228829,269252,66997 Esrrg,H3f3b,Cdk1,Maml1,Snapc1,Pgr,Trim33,Dnmt1,Gsr,Nxt1,Hipk2,Mre11a,Rps29,Ptbp1,Ndc1,Cpsf7,Maml2,Prkcd,Tead4,Gtf2e2,Hist2h4,Hnrnpa2b1,Prkaa2,Ppm1a,Pin1,Cwc22,Ppp2r5c,Tgif2,Ppp2r2a,Nt5c3b,Rora,Eif3m,Ints10,Rpa1,Aebp2,Gtf2f2,Tet2,Cited4,Rragc,Pcbp1,Tnrc6b,Nup210,Prkag3,Ccng1,Nuak1,Smg7,Gtf2a1,Plk3,Ar,Ell,Blm,Rad17,Ing2,Hist2h3c2,Notch2,Hist1h4n,Med4,Kmt5a,Psma3,Ncor2,Pan3,Srrm1,Cdk7,Hnrnpr,Snrpe,Hspa8,Psmd7,Rara,Mapk3,Vdr,Hus1,Med16,Drosha,Hist1h2ah,Rpl37rt,Nedd4l,Tdrd1,Ctnnbl1,Hnrnpk,Smad2,Papola,Igfbp3,Lsm3,Nabp1,Pparg,Nr4a3,Clns1a,Thrb,Sf3b1,Nrbf2,Dek,Ube2d1,Esrrb,Rptor,Cnot6l,Nr2e3,Smad3,Sarnp,Ywhaq,Nup153,Ehmt1,Notch1,Rplp1,Nup35,Wwox,Rxra,Cdc5l,Kat2b,Gtf3a,Rad50,Trp63,Ywhah,Nol11,Rps15a,Eif3c,Eaf1,Rpl35a,Rabggta,Runx2,Hnrnpa3,Rarb,Gspt1,Zrsr2,Rmi2,Thoc7,Ubc,C1d,Etf1,Nup214,Ddx49,Med27,Rnpc3,Psmd6,Utp25,Dcp2,Gtf3c1,Rarg,Tead1,Prr5,Hspa1b,Utp18,Kctd1,Xrn1,Smad7,Mbd2,Psme4,Tex10,Dnmt3a,Tbx5,Nr3c1,Anp32a,Mov10l1,Mapkap1,Myo1c,Mllt3,Sfn,Rplp0,Prkag2,Xab2,Tgif1,Csnk2a2,Sgk1,Cstf3,Phf20,Gtf3c4,Psmd12 R-MMU-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.997764300987637 -0.00223820191859194 75 5 0.00336927223719677 1484 8688 15081,97114,319168,319161,97122 H3f3b,Hist2h3c2,Hist1h2ah,Hist1h4n,Hist2h4 R-MMU-73863 RNA Polymerase I Transcription Termination 0.997957667591018 -0.0020444208137787 33 1 0.000673854447439353 1484 8688 12572 Cdk7 R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.998366651961936 -0.00163468340524856 104 8 0.00539083557951483 1484 8688 56347,20090,57808,100502825,98221,267019,56040,11837 Eif3c,Rps29,Rpl35a,Rpl37rt,Eif3m,Rps15a,Rplp1,Rplp0 R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.998427009789612 -0.00157422865837019 47 2 0.00134770889487871 1484 8688 57254,108073 Tas2r119,Grm7 R-MMU-1592389 Activation of Matrix Metalloproteinases 0.998671845478605 -0.00132903730034259 48 2 0.00134770889487871 1484 8688 17389,18550 Mmp16,Furin R-MMU-73762 RNA Polymerase I Transcription Initiation 0.998671845478605 -0.00132903730034259 48 2 0.00134770889487871 1484 8688 18519,12572 Kat2b,Cdk7 R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.998684225112482 -0.00131664127936264 97 7 0.00471698113207547 1484 8688 76947,28080,110842,68375,17993,22227,69487 Ndufaf6,Atp5o,Etfa,Ndufa8,Ndufs4,Ucp1,Ndufaf5 R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.998726776512699 -0.0012740347249892 106 8 0.00539083557951483 1484 8688 20090,56347,57808,11837,56040,98221,267019,100502825 Rps29,Eif3c,Rpl35a,Rplp0,Rplp1,Eif3m,Rps15a,Rpl37rt R-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane 0.998843816670535 -0.00115685222503733 89 6 0.00404312668463612 1484 8688 11837,56040,20090,57808,267019,100502825 Rplp0,Rplp1,Rps29,Rpl35a,Rps15a,Rpl37rt R-MMU-8868773 rRNA processing in the nucleus and cytosol 0.998997668820548 -0.00100283384927161 125 10 0.00673854447439353 1484 8688 234374,269536,217109,100502825,68979,57316,11837,56040,215193,57808 Ddx49,Tex10,Utp18,Rpl37rt,Nol11,C1d,Rplp0,Rplp1,Utp25,Rpl35a R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.998997668820548 -0.00100283384927161 125 10 0.00673854447439353 1484 8688 68979,100502825,217109,269536,234374,56040,11837,57316,215193,57808 Nol11,Rpl37rt,Utp18,Tex10,Ddx49,Rplp1,Rplp0,C1d,Utp25,Rpl35a R-MMU-72312 rRNA processing 0.998997668820548 -0.00100283384927161 125 10 0.00673854447439353 1484 8688 57808,215193,56040,57316,11837,217109,100502825,68979,234374,269536 Rpl35a,Utp25,Rplp1,C1d,Rplp0,Utp18,Rpl37rt,Nol11,Ddx49,Tex10 R-MMU-6805567 Keratinization 0.999031685533839 -0.000968783585474326 150 13 0.00876010781671159 1484 8688 332131,227937,18772,16664,18550,110308,13505,19143,71529,16668,74176,16480,406219 Krt78,Pkp4,Pkp1,Krt14,Furin,Krt5,Dsc1,St14,Kazn,Krt18,Tgm5,Jup,Krt87 R-MMU-5250941 Negative epigenetic regulation of rRNA expression 0.999109988328396 -0.000890407967147792 100 7 0.00471698113207547 1484 8688 319168,319161,15081,13433,97114,17191,97122 Hist1h2ah,Hist1h4n,H3f3b,Dnmt1,Hist2h3c2,Mbd2,Hist2h4 R-MMU-573389 NoRC negatively regulates rRNA expression 0.999118660804578 -0.000881727803157768 91 6 0.00404312668463612 1484 8688 13433,15081,97114,319168,319161,97122 Dnmt1,H3f3b,Hist2h3c2,Hist1h2ah,Hist1h4n,Hist2h4 R-MMU-72737 Cap-dependent Translation Initiation 0.999405222475967 -0.000594954474351864 112 8 0.00539083557951483 1484 8688 98221,267019,100502825,11837,56040,56347,20090,57808 Eif3m,Rps15a,Rpl37rt,Rplp0,Rplp1,Eif3c,Rps29,Rpl35a R-MMU-72613 Eukaryotic Translation Initiation 0.999405222475967 -0.000594954474351864 112 8 0.00539083557951483 1484 8688 20090,56347,57808,98221,267019,100502825,11837,56040 Rps29,Eif3c,Rpl35a,Eif3m,Rps15a,Rpl37rt,Rplp0,Rplp1 R-MMU-72766 Translation 0.999450565248069 -0.000549585746514855 130 10 0.00673854447439353 1484 8688 56347,20090,57808,14852,56040,11837,225363,100502825,98221,267019 Eif3c,Rps29,Rpl35a,Gspt1,Rplp1,Rplp0,Etf1,Rpl37rt,Eif3m,Rps15a R-MMU-211945 Phase 1 - Functionalization of compounds 0.999662513296284 -0.000337543665169477 151 12 0.00808625336927224 1484 8688 109754,13120,19224,18976,17161,228608,20181,14148,14149,232174,230639,21391 Cyb5r3,Cyp4b1,Ptgs1,Pomc,Maoa,Smox,Rxra,Fdx1,Fdxr,Cyp26b1,Cyp4a29,Tbxas1 R-MMU-1236975 Antigen processing-Cross presentation 0.999708833131591 -0.000291209265711275 99 6 0.00404312668463612 1484 8688 17463,66413,19167,12491,103554,66997 Psmd7,Psmd6,Psma3,Cd36,Psme4,Psmd12 R-MMU-6803157 Antimicrobial peptides 0.999987384217818 -1.26158617614634e-05 60 1 0.000673854447439353 1484 8688 21897 Tlr1 R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.999999990557118 -9.44288226630736e-09 115 2 0.00134770889487871 1484 8688 93694,16412 Clec2d,Itgb1 R-MMU-372790 Signaling by GPCR 0.999999992000458 -7.9995419447176e-09 1331 159 0.107142857142857 1484 8688 54199,22045,18976,11516,14709,19167,19417,18798,11876,14673,53972,57254,14062,26361,235584,14585,18430,259040,19735,14176,18673,23980,22044,19353,14677,244701,15550,18783,78134,240672,52250,29863,14183,26417,13490,71704,17463,20112,12778,16439,381489,233571,19220,20305,16867,18753,216749,24001,21336,16706,56066,73341,545156,207212,12767,22065,16367,13609,110157,11555,56696,14527,14309,212541,230972,11548,67653,108058,242851,380921,19419,14708,21333,230857,26931,30044,13645,13869,76089,57257,14678,14173,22355,18610,14696,243407,11820,14178,14186,66413,14688,103554,258408,108073,218461,16590,18708,14573,110651,213527,18578,11551,50780,237362,13617,26395,22190,54611,13615,16443,14773,26946,14702,64337,66997,14675,50501,109648,18167,14811,20606,384783,12775,14714,14293,21844,227288,20111,16452,11553,26364,11554,238377,15461,15466,14184,12314,13618,52666,320127,12776,381413,20742,16591,11606,213788,13874,14745,20300,14083,277360,67603,109934,226278,19227,231474,71111,69601,18575 Ccrl2,Trhr,Pomc,Adcyap1,Gng8,Psma3,Rasgrf1,Plcb4,Artn,Gna12,Ngef,Tas2r119,F2r,Avpr1b,Dusp7,Gfra1,Oxtr,Olfr1416,Rgs2,Fgf5,Phb,Pebp1,Trh,Rac1,Gnai1,Mtnr1b,Htr1a,Pla2g4a,Lpar4,Dusp5,Reep1,Pde7b,Fgfr2,Mapk3,Drd3,Arhgef3,Psmd7,Rps6ka2,Ackr3,Itpr2,Rxfp1,P2ry6,Ptgfr,Ccl6,Lhcgr,Prkcd,Nmur2,Tiam2,Tacr1,Ksr1,Cxcl11,Arhgef6,Kalrn,Arhgef17,Cxcr4,Trpc3,Irs1,S1pr1,Raf1,Adrb2,Gpr132,Gcgr,Fshr,Rho,Arhgef16,Adra1b,4930544G11Rik,Camk2d,Gnat3,Dgkh,Rasgrp1,Gng7,Tac1,Ece1,Ppp2r5c,Opn4,Egf,Erbb4,Rapgef2,Vav3,Gnai2,Fgf2,Vipr2,Pdyn,Gnb4,Qrfprl,App,Fgf7,Fgfr4,Psmd6,Gnb1,Psme4,Olfr463,Grm7,Pde8b,Kit,Pik3r1,Gdnf,Rps6ka3,Pth2r,Pde4b,Adra2a,Rgs3,Npffr1,Ednra,Map2k1,Ubc,Pde3a,Edn2,Itsn1,Grk5,Trpc7,Gng2,Gng13,Psmd12,Gna14,Prok2,Npy,Npy2r,Grin2a,Sstr2,Irs2,Ccr7,Gnrh1,Fpr1,Tiam1,Cxcr1,Rps6ka1,Jak2,Adra2c,Adgre5,Adrb1,Gpr68,Hras,Hrh2,Fgfr3,Calm2,Ednrb,Arhgef25,Dgki,Ccr8,Gpr176,Sptbn1,Kl,Agt,Chrm5,Ereg,Lpar1,Ccl25,Ptk2,Prex1,Dusp6,Abr,Prlhr,Pthlh,Paqr3,Gpr39,Dab2ip,Pde1c R-MMU-388396 GPCR downstream signaling 0.999999999867952 -1.32047711707327e-10 1065 102 0.068733153638814 1484 8688 14688,18976,11516,22045,18708,18798,108073,218461,258408,11551,18578,50780,57254,14062,213527,26361,53972,14673,13615,54611,13617,18430,237362,259040,14702,26946,16443,19735,14773,19353,18167,109648,22044,50501,14675,52250,227288,21844,14293,14714,15550,12775,78134,14677,20606,244701,11553,16439,233571,381489,16452,71704,12778,13490,29863,56066,216749,18753,24001,21336,238377,19220,16867,20305,11554,12767,13618,22065,52666,545156,15466,207212,73341,381413,11555,12776,320127,13609,11548,14745,230972,213788,14527,212541,14309,11606,56696,380921,67653,242851,20300,21333,277360,14678,22355,109934,57257,30044,11820,243407,18610,19227 Gnb1,Pomc,Adcyap1,Trhr,Pik3r1,Plcb4,Grm7,Pde8b,Olfr463,Adra2a,Pde4b,Rgs3,Tas2r119,F2r,Pth2r,Avpr1b,Ngef,Gna12,Edn2,Pde3a,Ednra,Oxtr,Npffr1,Olfr1416,Gng2,Trpc7,Itsn1,Rgs2,Grk5,Rac1,Npy2r,Npy,Trh,Prok2,Gna14,Reep1,Cxcr1,Tiam1,Fpr1,Gnrh1,Htr1a,Ccr7,Lpar4,Gnai1,Sstr2,Mtnr1b,Adra2c,Itpr2,P2ry6,Rxfp1,Jak2,Arhgef3,Ackr3,Drd3,Pde7b,Cxcl11,Nmur2,Prkcd,Tiam2,Tacr1,Gpr68,Ptgfr,Lhcgr,Ccl6,Adrb1,Cxcr4,Ednrb,Trpc3,Arhgef25,Kalrn,Hrh2,Arhgef17,Arhgef6,Gpr176,Adrb2,Ccr8,Dgki,S1pr1,Adra1b,Lpar1,Arhgef16,Chrm5,Gcgr,Rho,Fshr,Agt,Gpr132,Dgkh,4930544G11Rik,Gnat3,Ccl25,Tac1,Prex1,Gnai2,Vipr2,Abr,Vav3,Opn4,App,Qrfprl,Pdyn,Pthlh R-MMU-381753 Olfactory Signaling Pathway 0.999999999915149 -8.4850800325455e-11 535 4 0.00269541778975741 1484 8688 14688,52250,258408,259040 Gnb1,Reep1,Olfr463,Olfr1416