TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-MMU-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.901943246763643 -0.10320368022979 104 23 0.00973751058425064 2362 8688 27015,12021,12144,67967,69263,22190,15574,19687,11350,17535,232314,68275,107976,319161,19360,27223,13870,225182,97122,19356,19363,223970,70620 Polk,Bard1,Blm,Pold3,Rfc3,Ubc,Hus1,Rfc1,Abl1,Mre11a,Ppp4r2,Rpa1,Babam2,Hist1h4n,Rad50,Trp53bp1,Ercc1,Rbbp8,Hist2h4,Rad17,Rad51b,Rmi2,Ube2v2 R-MMU-69541 Stabilization of p53 0.90343842190041 -0.101547326335703 54 11 0.00465707027942422 2362 8688 26443,26440,17463,19177,103554,66997,66413,19167,22190,17248,66998 Psma6,Psma1,Psmd7,Psmb7,Psme4,Psmd12,Psmd6,Psma3,Ubc,Mdm4,Psmd5 R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1 0.90343842190041 -0.101547326335703 54 11 0.00465707027942422 2362 8688 103554,19177,66413,66997,26443,26440,17463,107995,66998,19167,22190 Psme4,Psmb7,Psmd6,Psmd12,Psma6,Psma1,Psmd7,Cdc20,Psmd5,Psma3,Ubc R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.905507741413583 -0.0992594523704402 13 2 0.000846740050804403 2362 8688 15122,11826 Hba-a1,Aqp1 R-MMU-166208 mTORC1-mediated signalling 0.90746559388874 -0.097099626632109 23 4 0.00169348010160881 2362 8688 74370,54170,13631,19744 Rptor,Rragc,Eef2k,Rheb R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6 0.907609865004564 -0.0969406568047986 50 10 0.00423370025402202 2362 8688 66998,19167,22190,103554,19177,66997,66413,26443,26440,17463 Psmd5,Psma3,Ubc,Psme4,Psmb7,Psmd12,Psmd6,Psma6,Psma1,Psmd7 R-MMU-174143 APC/C-mediated degradation of cell cycle proteins 0.908445505554621 -0.0960203758237443 84 18 0.00762066045723963 2362 8688 103554,66413,68999,26440,22194,216080,18005,66998,19167,22190,19177,229776,12534,66997,26443,56150,17463,107995 Psme4,Psmd6,Anapc10,Psma1,Ube2e1,Ube2d1,Nek2,Psmd5,Psma3,Ubc,Psmb7,Cdc14a,Cdk1,Psmd12,Psma6,Mad2l1,Psmd7,Cdc20 R-MMU-453276 Regulation of mitotic cell cycle 0.908445505554621 -0.0960203758237443 84 18 0.00762066045723963 2362 8688 56150,26443,17463,19177,229776,12534,66997,107995,68999,22194,26440,103554,66413,19167,22190,216080,66998,18005 Mad2l1,Psma6,Psmd7,Psmb7,Cdc14a,Cdk1,Psmd12,Cdc20,Anapc10,Ube2e1,Psma1,Psme4,Psmd6,Psma3,Ubc,Ube2d1,Psmd5,Nek2 R-MMU-5250924 B-WICH complex positively regulates rRNA expression 0.908958918672607 -0.0954553798054671 63 13 0.00550381033022862 2362 8688 11461,110052,319161,15081,81898,93762,15078,97122,97114,18519,17913,21340,20018 Actb,Dek,Hist1h4n,H3f3b,Sf3b1,Smarca5,H3f3a,Hist2h4,Hist2h3c2,Kat2b,Myo1c,Taf1b,Polr1d R-MMU-5693538 Homology Directed Repair 0.910403193041357 -0.0938677083212337 109 24 0.0101608806096528 2362 8688 27015,12021,12144,67967,69263,22190,15574,19687,11350,17535,232314,68275,107976,27223,319161,19360,13870,225182,11545,97122,19356,19363,223970,70620 Polk,Bard1,Blm,Pold3,Rfc3,Ubc,Hus1,Rfc1,Abl1,Mre11a,Ppp4r2,Rpa1,Babam2,Trp53bp1,Hist1h4n,Rad50,Ercc1,Rbbp8,Parp1,Hist2h4,Rad17,Rad51b,Rmi2,Ube2v2 R-MMU-176187 Activation of ATR in response to replication stress 0.91067866084977 -0.093565176274224 37 7 0.00296359017781541 2362 8688 19356,15574,12544,17217,69263,12545,68275 Rad17,Hus1,Cdc45,Mcm4,Rfc3,Cdc7,Rpa1 R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome 0.912182837059217 -0.0919148297694842 59 12 0.00508044030482642 2362 8688 17463,26440,26443,93687,66413,66997,103554,19177,22190,14634,19167,66998 Psmd7,Psma1,Psma6,Csnk1a1,Psmd6,Psmd12,Psme4,Psmb7,Ubc,Gli3,Psma3,Psmd5 R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase 0.912312934219058 -0.0917722181371532 76 16 0.00677392040643522 2362 8688 66997,19177,12534,17463,56150,26443,107995,66413,103554,22194,26440,68999,66998,216080,22190,19167 Psmd12,Psmb7,Cdk1,Psmd7,Mad2l1,Psma6,Cdc20,Psmd6,Psme4,Ube2e1,Psma1,Anapc10,Psmd5,Ube2d1,Ubc,Psma3 R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.919975770487088 -0.0834079457129396 51 10 0.00423370025402202 2362 8688 66998,22190,19167,66413,66997,19177,103554,26440,17463,26443 Psmd5,Ubc,Psma3,Psmd6,Psmd12,Psmb7,Psme4,Psma1,Psmd7,Psma6 R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 20698 Sphk1 R-MMU-444821 Relaxin receptors 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 381489 Rxfp1 R-MMU-70921 Histidine catabolism 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 14317 Ftcd R-MMU-2514853 Condensation of Prometaphase Chromosomes 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 13000 Csnk2a2 R-MMU-193144 Estrogen biosynthesis 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 15485 Hsd17b1 R-MMU-2161522 Abacavir transport and metabolism 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 20517 Slc22a1 R-MMU-5652084 Fructose metabolism 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 20322 Sord R-MMU-201688 WNT mediated activation of DVL 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 13000 Csnk2a2 R-MMU-1300644 Interaction With The Zona Pellucida 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 71078 Adam30 R-MMU-189085 Digestion of dietary carbohydrate 0.921086366448948 -0.0822014724774171 8 1 0.000423370025402202 2362 8688 232714 Mgam R-MMU-156580 Phase II conjugation 0.922232695671288 -0.080957705846156 77 16 0.00677392040643522 2362 8688 242585,23971,108652,14630,232087,13885,68214,108645,13521,216558,211666,107146,23972,18113,14629,69065 Slc35d1,Papss1,Slc35b3,Gclm,Mat2a,Esd,Gsto2,Mat2b,Slc26a2,Ugp2,Mgst2,Glyat,Papss2,Nnmt,Gclc,Chac1 R-MMU-211935 Fatty acids 0.923270022154625 -0.0798335388833433 19 3 0.0012701100762066 2362 8688 13120,230639,13109 Cyp4b1,Cyp4a29,Cyp2j5 R-MMU-77595 Processing of Intronless Pre-mRNAs 0.923270022154625 -0.0798335388833433 19 3 0.0012701100762066 2362 8688 228410,269061,18789 Cstf3,Cpsf7,Papola R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.9246769676932 -0.0783108265781138 47 9 0.00381033022861981 2362 8688 66998,19167,19177,103554,66997,66413,26443,26440,17463 Psmd5,Psma3,Psmb7,Psme4,Psmd12,Psmd6,Psma6,Psma1,Psmd7 R-MMU-69298 Association of licensing factors with the pre-replicative complex 0.926838660313812 -0.075975773532784 14 2 0.000846740050804403 2362 8688 13555,22190 E2f1,Ubc R-MMU-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 0.930021001606731 -0.0725481107169843 43 8 0.00338696020321761 2362 8688 66514,72947,14317,20539,78920,107766,217593,209176 Asrgl1,Phykpl,Ftcd,Slc7a5,Dlst,Haao,Slc25a21,Ido2 R-MMU-212300 PRC2 methylates histones and DNA 0.930021001606731 -0.0725481107169843 43 8 0.00338696020321761 2362 8688 97114,97122,15078,15081,13433,319161,11569,13435 Hist2h3c2,Hist2h4,H3f3a,H3f3b,Dnmt1,Hist1h4n,Aebp2,Dnmt3a R-MMU-69613 p53-Independent G1/S DNA damage checkpoint 0.930902474263689 -0.0716007609368212 52 10 0.00423370025402202 2362 8688 66998,22190,19167,66413,66997,103554,19177,26440,17463,26443 Psmd5,Ubc,Psma3,Psmd6,Psmd12,Psme4,Psmb7,Psma1,Psmd7,Psma6 R-MMU-69610 p53-Independent DNA Damage Response 0.930902474263689 -0.0716007609368212 52 10 0.00423370025402202 2362 8688 66998,22190,19167,66997,66413,19177,103554,26440,17463,26443 Psmd5,Ubc,Psma3,Psmd12,Psmd6,Psmb7,Psme4,Psma1,Psmd7,Psma6 R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.930902474263689 -0.0716007609368212 52 10 0.00423370025402202 2362 8688 19167,22190,66998,26443,26440,17463,103554,19177,66413,66997 Psma3,Ubc,Psmd5,Psma6,Psma1,Psmd7,Psme4,Psmb7,Psmd6,Psmd12 R-MMU-69242 S Phase 0.931390471775164 -0.0710766784892325 124 27 0.0114309906858594 2362 8688 22190,22390,77805,19167,19687,69263,66998,19357,26440,67967,12572,71521,66413,103554,17217,12443,17463,26443,19076,18974,66997,100710,18968,68275,12447,16881,19177 Ubc,Wee1,Esco1,Psma3,Rfc1,Rfc3,Psmd5,Rad21,Psma1,Pold3,Cdk7,Pds5a,Psmd6,Psme4,Mcm4,Ccnd1,Psmd7,Psma6,Prim2,Pole2,Psmd12,Pds5b,Pola1,Rpa1,Ccne1,Lig1,Psmb7 R-MMU-113418 Formation of the Early Elongation Complex 0.931707169167097 -0.070736709839148 34 6 0.00254022015241321 2362 8688 12572,24116,13871,68705,20924,67655 Cdk7,Nelfa,Ercc2,Gtf2f2,Supt5,Ctdp1 R-MMU-5334727 Mus musculus biological processes 0.936072124875421 -0.0660627489824095 238 55 0.0232853513971211 2362 8688 12952,20848,15078,59027,22410,19883,68275,20018,16905,16452,11865,97114,51788,66654,20602,12144,15081,64009,19017,13654,22190,69790,20181,16600,19016,20851,16846,68910,13433,12609,20787,319161,12224,16367,67381,16906,77053,12702,67279,23856,97122,93762,68975,19247,18143,12953,79362,319168,14815,19357,15182,76199,384783,13591,216154 Cry1,Stat3,H3f3a,Nampt,Wnt10b,Rora,Rpa1,Polr1d,Lmna,Jak2,Arntl,Hist2h3c2,H2afz,Tex12,Ncor2,Blm,H3f3b,Syne1,Ppargc1a,Egr2,Ubc,Med30,Rxra,Klf4,Pparg,Stat5b,Lep,Zfp467,Dnmt1,Cebpd,Srebf1,Hist1h4n,Klf5,Irs1,Med4,Lmnb1,Sun1,Socs3,Med31,Dido1,Hist2h4,Smarca5,Med27,Ptpn11,Npas2,Cry2,Bhlhe41,Hist1h2ah,Nr3c1,Rad21,Hdac2,Med13l,Irs2,Ebf1,Med16 R-MMU-5610780 Degradation of GLI1 by the proteasome 0.93662611528177 -0.0654710995531214 57 11 0.00465707027942422 2362 8688 19167,22190,18222,66998,26443,17463,26440,19177,103554,66997,66413 Psma3,Ubc,Numb,Psmd5,Psma6,Psmd7,Psma1,Psmb7,Psme4,Psmd12,Psmd6 R-MMU-4641258 Degradation of DVL 0.93662611528177 -0.0654710995531214 57 11 0.00465707027942422 2362 8688 17463,26440,26443,66997,66413,19177,103554,22190,59036,19167,66998 Psmd7,Psma1,Psma6,Psmd12,Psmd6,Psmb7,Psme4,Ubc,Dact1,Psma3,Psmd5 R-MMU-2467813 Separation of Sister Chromatids 0.938147506955448 -0.0638480854573387 166 37 0.0156646909398815 2362 8688 52504,100710,13589,56150,66977,66336,226747,26932,26931,17120,52696,67629,66413,26440,236930,208628,22190,83431,19177,66997,26443,17463,107995,108000,103554,76499,71521,68999,22194,56430,110379,19357,216080,66998,19167,16319,72415 Cenpo,Pds5b,Mapre1,Mad2l1,Nuf2,Cenpp,Ahctf1,Ppp2r5e,Ppp2r5c,Mad1l1,Zwint,Spc24,Psmd6,Psma1,Ercc6l,Kntc1,Ubc,Ndel1,Psmb7,Psmd12,Psma6,Psmd7,Cdc20,Cenpf,Psme4,Clasp2,Pds5a,Anapc10,Ube2e1,Clip1,Sec13,Rad21,Ube2d1,Psmd5,Psma3,Incenp,Sgo1 R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry 0.938813042691184 -0.0631389221627203 66 13 0.00550381033022862 2362 8688 19177,12447,66997,66413,26443,12572,26440,17463,66998,12443,22390,19167,22190 Psmb7,Ccne1,Psmd12,Psmd6,Psma6,Cdk7,Psma1,Psmd7,Psmd5,Ccnd1,Wee1,Psma3,Ubc R-MMU-69202 Cyclin E associated events during G1/S transition 0.938813042691184 -0.0631389221627203 66 13 0.00550381033022862 2362 8688 12447,66997,66413,19177,26440,17463,12572,26443,12443,66998,22190,19167,22390 Ccne1,Psmd12,Psmd6,Psmb7,Psma1,Psmd7,Cdk7,Psma6,Ccnd1,Psmd5,Ubc,Psma3,Wee1 R-MMU-171052 LDL-mediated lipid transport 0.938874308172803 -0.0630736658445028 20 3 0.0012701100762066 2362 8688 20652,320024,238055 Soat1,Nceh1,Apob R-MMU-390918 Peroxisomal lipid metabolism 0.94027693521754 -0.0615808351741084 30 5 0.00211685012701101 2362 8688 20524,74114,15926,74121,15488 Slc25a17,Crot,Idh1,Acoxl,Hsd17b4 R-MMU-69563 p53-Dependent G1 DNA Damage Response 0.941876230017217 -0.0598814036781771 62 12 0.00508044030482642 2362 8688 26443,26440,17463,19177,103554,66413,66997,12447,19167,22190,17248,66998 Psma6,Psma1,Psmd7,Psmb7,Psme4,Psmd6,Psmd12,Ccne1,Psma3,Ubc,Mdm4,Psmd5 R-MMU-69580 p53-Dependent G1/S DNA damage checkpoint 0.941876230017217 -0.0598814036781771 62 12 0.00508044030482642 2362 8688 17248,66998,19167,22190,19177,103554,66997,66413,12447,26443,26440,17463 Mdm4,Psmd5,Psma3,Ubc,Psmb7,Psme4,Psmd12,Psmd6,Ccne1,Psma6,Psma1,Psmd7 R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.941876230017217 -0.0598814036781771 62 12 0.00508044030482642 2362 8688 216080,66998,19167,22190,19177,66413,66997,26443,68999,17463,26440,22194 Ube2d1,Psmd5,Psma3,Ubc,Psmb7,Psmd6,Psmd12,Psma6,Anapc10,Psmd7,Psma1,Ube2e1 R-MMU-110329 Cleavage of the damaged pyrimidine 0.942560329866026 -0.0591553512406219 9 1 0.000423370025402202 2362 8688 18294 Ogg1 R-MMU-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.942560329866026 -0.0591553512406219 9 1 0.000423370025402202 2362 8688 15107 Hadh R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.942560329866026 -0.0591553512406219 9 1 0.000423370025402202 2362 8688 108043 Chrnb3 R-MMU-73928 Depyrimidination 0.942560329866026 -0.0591553512406219 9 1 0.000423370025402202 2362 8688 18294 Ogg1 R-MMU-429947 Deadenylation of mRNA 0.942560329866026 -0.0591553512406219 9 1 0.000423370025402202 2362 8688 72587 Pan3 R-MMU-391908 Prostanoid ligand receptors 0.942560329866026 -0.0591553512406219 9 1 0.000423370025402202 2362 8688 19220 Ptgfr R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 0.943025547066022 -0.0586619054473256 35 6 0.00254022015241321 2362 8688 97114,319161,97122,15078,11835,15081 Hist2h3c2,Hist1h4n,Hist2h4,H3f3a,Ar,H3f3b R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.943994235672954 -0.0576352191339299 71 14 0.00592718035563082 2362 8688 107995,216080,66998,19167,22190,103554,19177,66413,66997,68999,26443,26440,22194,17463 Cdc20,Ube2d1,Psmd5,Psma3,Ubc,Psme4,Psmb7,Psmd6,Psmd12,Anapc10,Psma6,Psma1,Ube2e1,Psmd7 R-MMU-112382 Formation of RNA Pol II elongation complex 0.945244065759463 -0.0563121141895815 58 11 0.00465707027942422 2362 8688 13716,13871,68705,235497,74427,20924,67655,72949,12572,24116,70122 Ell,Ercc2,Gtf2f2,Leo1,Eaf1,Supt5,Ctdp1,Ccnt2,Cdk7,Nelfa,Mllt3 R-MMU-75955 RNA Polymerase II Transcription Elongation 0.945244065759463 -0.0563121141895815 58 11 0.00465707027942422 2362 8688 74427,235497,13871,13716,68705,70122,24116,12572,72949,67655,20924 Eaf1,Leo1,Ercc2,Ell,Gtf2f2,Mllt3,Nelfa,Cdk7,Ccnt2,Ctdp1,Supt5 R-MMU-2262752 Cellular responses to stress 0.948762232610553 -0.0525970569582591 360 85 0.0359864521591871 2362 8688 20657,19744,23872,20112,11758,216080,29806,216850,26416,18033,227720,97122,71805,26443,66997,319161,74370,26419,17248,26440,15081,26417,54170,66413,241113,72787,11793,12359,14780,108058,68196,97114,15078,29810,50932,77683,23871,57436,19167,16476,52639,68942,66998,15251,22194,218210,15901,68999,26399,17969,103554,108099,12579,12571,15481,17684,110651,108079,14782,112407,17463,16906,14778,17535,19177,22190,20111,69482,50490,15511,26420,75608,12017,228361,74244,15516,12460,68118,54563,12447,67443,54383,68275,66734,19360 Sod3,Rheb,Ets2,Rps6ka2,Prdx6,Ube2d1,Limd1,Kdm6b,Mapk14,Nfkb1,Nup214,Hist2h4,Nup93,Psma6,Psmd12,Hist1h4n,Rptor,Mapk8,Mdm4,Psma1,H3f3b,Mapk3,Rragc,Psmd6,Prkag3,Ndc1,Atg5,Cat,Gpx5,Camk2d,Hsbp1,Hist2h3c2,H3f3a,Bag3,Mink1,Ehmt1,Ets1,Gabarapl1,Psma3,Jun,Wipi1,Chmp2b,Psmd5,Hif1a,Ube2e1,Nup153,Id1,Anapc10,Map2k6,Ncf1,Psme4,Prkag2,Cdkn2b,Cdk6,Hspa8,Cited2,Rps6ka3,Prkaa2,Gsr,Egln3,Psmd7,Lmnb1,Gpx3,Mre11a,Psmb7,Ubc,Rps6ka1,Nup35,Nox4,Hspa1b,Mapk9,Chmp4b,Bag1,Ambra1,Atg7,Hsp90ab1,Ccs,Atg101,Nup210,Ccne1,Map1lc3b,Phc2,Rpa1,Map1lc3a,Rad50 R-MMU-6809371 Formation of the cornified envelope 0.948944485778912 -0.0524049796818784 54 10 0.00423370025402202 2362 8688 18772,74176,76560,227937,16480,13505,12336,19143,71529,18550 Pkp1,Tgm5,Prss8,Pkp4,Jup,Dsc1,Capns1,St14,Kazn,Furin R-MMU-69306 DNA Replication 0.949305727401114 -0.0520243748237258 106 22 0.00931414055884843 2362 8688 19076,26443,18974,17463,19177,66997,18968,16881,68275,12545,13555,17217,67967,26440,103554,66413,19687,19167,22190,12544,66998,69263 Prim2,Psma6,Pole2,Psmd7,Psmb7,Psmd12,Pola1,Lig1,Rpa1,Cdc7,E2f1,Mcm4,Pold3,Psma1,Psme4,Psmd6,Rfc1,Psma3,Ubc,Cdc45,Psmd5,Rfc3 R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.949620230417048 -0.0516931317676024 45 8 0.00338696020321761 2362 8688 13871,13716,68705,20924,72949,67655,24116,12572 Ercc2,Ell,Gtf2f2,Supt5,Ccnt2,Ctdp1,Nelfa,Cdk7 R-MMU-6807505 RNA polymerase II transcribes snRNA genes 0.951088800144437 -0.0501478452497713 72 14 0.00592718035563082 2362 8688 13716,68705,18130,101861,63856,68153,109019,72949,192657,218333,70885,12572,83602,75627 Ell,Gtf2f2,Ints6,Ints4,Taf8,Gtf2e2,Nabp1,Ccnt2,Ell2,Ice1,Ints10,Cdk7,Gtf2a1,Snapc1 R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 0.952820597328427 -0.0483286434916372 59 11 0.00465707027942422 2362 8688 26443,17463,26440,19177,12447,66997,66413,19167,22190,66998,12443 Psma6,Psmd7,Psma1,Psmb7,Ccne1,Psmd12,Psmd6,Psma3,Ubc,Psmd5,Ccnd1 R-MMU-1834949 Cytosolic sensors of pathogen-associated DNA 0.952820597328427 -0.0483286434916372 59 11 0.00465707027942422 2362 8688 15289,20018,18033,69807,22190,20203,17535,11820,58203,18035,72162 Hmgb1,Polr1d,Nfkb1,Trim32,Ubc,S100b,Mre11a,App,Zbp1,Nfkbia,Dhx36 R-MMU-2132295 MHC class II antigen presentation 0.953551152809129 -0.0475622079667601 94 19 0.00804403048264183 2362 8688 13426,209737,110379,11768,99683,13429,64291,668303,20404,218275,235661,252903,66397,67665,16579,22428,16593,14961,11765 Dync1i1,Kif15,Sec13,Ap1m2,Sec24b,Dnm1,Osbpl1a,Kif26a,Sh3gl2,BC051665,Dync1li1,Ap1s3,Sar1b,Dctn4,Kifap3,Dctn6,Klc1,H2-Ab1,Ap1g1 R-MMU-6798695 Neutrophil degranulation 0.953741259057804 -0.0473628612403515 561 136 0.0575783234546994 2362 8688 208795,21938,16970,30960,105245,15516,269116,74244,71517,78892,67512,72157,20195,232714,14590,72269,56016,20409,216197,231507,20716,106572,13032,11717,11674,14293,109905,70152,72065,18805,69660,83768,102595,29875,66612,12505,16211,12509,117586,18648,16414,19342,66713,13014,66413,20813,15369,18405,70450,74012,66997,74039,110095,11846,14319,71902,26416,52588,12306,11758,67653,15926,71884,109754,76577,19271,68682,15511,12491,70536,14190,20430,72461,19177,18753,13367,16498,17463,16004,21858,18792,16790,15481,16410,20868,14667,16480,26364,23912,19261,241633,12331,19276,75612,11625,17064,110173,104009,619326,53378,24088,12359,210992,80860,107767,18772,435350,16854,442827,74096,14302,104112,55950,13030,74287,15442,18600,227288,22596,235661,227753,56444,18033,19353,70495,18641,16592,64138,17380,15289,14134,13505,216134,100040563,229574,110078 Tmem63a,Tnfrsf1b,Lrmp,Vapa,Txndc5,Hsp90ab1,Nfasc,Atg7,Vps35l,Crispld2,Agpat2,Pgm2,S100a11,Mgam,Ggh,Cda,Hebp2,Ostf1,Ckap4,Plac8,Serpina3n,Rab31,Ctsc,Ampd3,Aldoa,Fpr1,Rap1a,Mettl7a1,Rap2c,Pld1,Tmbim1,Dpp7,Plekho2,Iqgap1,Ormdl3,Cd44,Kpnb1,Cd59a,A1bg,Pgam1,Itgb2,Rab4b,Actr2,Cstb,Psmd6,Srp14,Hmox2,Orm1,Unc13d,Rap2b,Psmd12,Nfam1,Pygl,Arg1,Fth1,Cand1,Mapk14,Tspan14,Anxa2,Prdx6,4930544G11Rik,Idh1,Chit1,Cyb5r3,Faf2,Ptprj,Slc44a2,Hspa1b,Cd36,Qpct,Fgl2,Cyfip1,Prcp,Psmb7,Prkcd,Diaph1,Kcnab2,Psmd7,Igf2r,Timp2,Plau,Anpep,Hspa8,Itgav,Stk10,Gm2a,Jup,Adgre5,Rhof,Sirpa,Atp8b4,Cap1,Ptprn2,Gns,Ahsg,Cd93,Manba,Qsox1,9130409I23Rik,Sdcbp,Tlr2,Cat,Lpcat1,Ghdc,Scamp1,Pkp1,Serpinb6e,Lgals3,Rab44,Hvcn1,Frk,Acly,Bri3,Ctsb,Kcmf1,Hpse,Padi2,Cxcr1,Xrcc5,Dync1li1,Gsn,Actr10,Nfkb1,Rac1,Atp6ap2,Pfkl,Fabp5,Ctsz,Mme,Hmgb1,Fcnb,Dsc1,Pdxk,Dynlt1c,Flg2,Pygb R-MMU-5696398 Nucleotide Excision Repair 0.956095153391706 -0.0448978380472869 103 21 0.00889077053344623 2362 8688 67967,12572,11461,27015,67439,22190,19687,69263,56469,13871,19359,71101,11545,68275,16881,13870,70620,108679,68142,227195,225280 Pold3,Cdk7,Actb,Polk,Xab2,Ubc,Rfc1,Rfc3,Pias1,Ercc2,Rad23b,Uvssa,Parp1,Rpa1,Lig1,Ercc1,Ube2v2,Cops8,Ino80,Ino80d,Ino80c R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.956302195443103 -0.0446813118611034 55 10 0.00423370025402202 2362 8688 66998,19167,22190,103554,19177,66413,66997,26443,17463,26440 Psmd5,Psma3,Ubc,Psme4,Psmb7,Psmd6,Psmd12,Psma6,Psmd7,Psma1 R-MMU-69615 G1/S DNA Damage Checkpoints 0.95644843818322 -0.0445283983157295 64 12 0.00508044030482642 2362 8688 19167,22190,17248,66998,26443,26440,17463,19177,103554,66997,12447,66413 Psma3,Ubc,Mdm4,Psmd5,Psma6,Psma1,Psmd7,Psmb7,Psme4,Psmd12,Ccne1,Psmd6 R-MMU-392499 Metabolism of proteins 0.95655805341521 -0.0444137983574005 1115 280 0.118543607112616 2362 8688 11461,57357,22193,107221,57808,70008,110379,19359,22034,230801,12314,239706,16323,30940,216197,14702,54161,16846,13032,109785,76687,320011,244682,67872,26938,74256,74762,17342,67128,107895,235505,11889,267019,21951,24012,140740,18550,330908,17155,20451,107607,107260,16319,26443,67665,14688,67819,94192,71805,16009,22230,228366,20813,66413,20741,78232,26440,68436,170711,14677,70546,78754,107976,171212,17425,12097,18491,14465,11551,20742,16000,11606,237847,12021,74996,68501,17126,68135,80883,21812,226641,18035,22194,19357,231130,66111,235497,78928,13426,242851,19167,18519,67952,320183,17463,14526,73582,66397,18976,19981,11835,13000,105522,69482,20698,11837,54383,50873,70574,225363,231605,20687,14376,235441,21802,13982,27392,66624,70495,22217,64138,218476,216080,99683,56469,64337,218138,59040,72061,14584,68404,21969,235661,229595,20442,227720,227195,72787,17248,15387,56358,20090,100502825,66174,67561,23802,71954,21838,16006,23794,12042,12096,22213,30060,19211,27223,11890,107995,217364,56187,225131,72434,381694,54198,23956,54342,72978,22658,18970,320840,108153,19128,22214,12313,18548,16333,50798,77739,56494,67196,11553,271970,320772,66050,16324,56040,71897,67653,56336,74008,66997,22428,67569,16008,99011,234700,170707,68947,109978,20447,545260,67099,59021,12509,19739,20441,103554,22031,26409,218210,66998,15251,14696,329777,216131,19177,20454,108148,227327,17131,14537,338337,66568,216150,327799,53869,15481,320311,89867,12005,11735,19326,109359,233824,22190,98221,68275,54563,11545,66212,217869,21684,269181,109676,98388,69048,235504,56233,241230,230145,14678,54613,246103,17380,228998,18488,229603,17127,217337,30937,23850,207352,11555,77038,53618,56347,68142,17125,53625,235106,12144,21973,53334,20440,20450,12876,192193,225280,14852,12006 Actb,Srd5a3,Ube2e3,Ffar4,Rpl35a,Ace2,Sec13,Rad23b,Traf6,Pigv,Calm2,Mettl22,Inhba,Usp25,Ckap4,Gng2,Copg1,Lep,Ctsc,Pgm3,Spcs3,Uggt1,Cntn5,Nsmce4a,St6galnac5,Cyld,Mdga1,Mitf,Ube2g1,Mgat5,Cd109,Asgr1,Rps15a,Tnks,Rgs7,Sec63,Furin,Opcml,Man1a,St8sia3,Nod1,Otub1,Incenp,Psma6,Dctn4,Gnb1,Derl1,C1galt1,Nup93,Igfbp3,Ufd1,Large2,Srp14,Psmd6,Sptb,Trappc6b,Psma1,Rpl34,Otud7a,Gnai1,Zdhhc2,Galnt15,Babam2,Galnt10,Foxk1,Bglap2,Pappa,Gata6,Adra2a,Sptbn1,Igf1,Agt,Rtn4rl1,Bard1,Usp47,Nsmce2,Smad2,Eif3h,Ntng1,Tgfbr1,Atf6,Nfkbia,Ube2e1,Rad21,Tnip2,Tmed3,Leo1,Pigt,Dync1i1,Gnat3,Psma3,Kat2b,Tomm20,Msrb3,Psmd7,Gcg,Camkmt,Sar1b,Pomc,Rpl37a,Ar,Csnk2a2,Ankrd28,Nup35,Sphk1,Rplp0,Phc2,Prkn,Cpm,Etf1,Galnt9,Sp3,Ganab,Usp3,Tgfa,Esr1,Pign,Spcs2,Atp6ap2,Usp12,Ctsz,Gcnt4,Ube2d1,Sec24b,Pias1,Gng13,Gmds,Rhot1,Aopep,Gfpt2,Nrn1,Top1,Dync1li1,Adamtsl4,St3gal1,Nup214,Ino80d,Ndc1,Mdm4,Hnrnpk,Copz2,Rps29,Rpl37rt,Nudt14,Wdr48,Amfr,Suds3,Thy1,Igfbp1,Adamts5,Bcl10,Bglap,Ube2g2,Meltf,Pten,Trp53bp1,Asgr2,Cdc20,Engase,Rabggta,Wac,Lypd3,B3glct,Snx3,Neu2,Gnpnat1,Cnih3,Pcgf2,Polb,Negr1,Adamts7,Pros1,Ube2h,Calm1,Pcsk1,Ins1,Gne,Adamtsl1,Gosr2,Ube2t,Adra2c,Arsj,Mdga2,0610009B22Rik,Inhbb,Rplp1,Lypd6b,4930544G11Rik,B4galt5,Arsg,Psmd12,Dctn6,Mgat4c,Igfbp2,Pomt1,Nrn1l,Usp48,Chst8,Art4,St6galnac3,Arsi,Mettl21a,Rab2a,Cd59a,Rgs9,St3gal3,Psme4,Traf3,Map3k7,Nup153,Psmd5,Hif1a,Gnb4,Pigk,Trappc10,Psmb7,St3gal5,Galnt2,B3gnt7,Smad7,Gcnt1,Cog3,Rwdd3,Cdc34,Usp44,Rab11a,Hspa8,Rnf152,Sec16b,Axin1,Ank3,Rab11b,Abraxas2,Cog7,Ubc,Eif3m,Rpa1,Nup210,Parp1,Sec61b,Eif5,Tectb,Mgat4a,Ank2,Chst10,Slc30a5,Slc17a5,Hdac7,St8sia6,Galnt12,Gnai2,St3gal6,Atxn7,Mme,Arfgap1,Cntn3,Otud7b,Smad3,Srp68,Lmcd1,Pappa2,Sec23ip,Adrb2,Arfgap2,Fut8,Eif3c,Ino80,Smad1,B3gnt2,Ntm,Blm,Top2a,Gosr1,St6gal1,St8sia2,Cpe,Edem1,Ino80c,Gspt1,Axin2 R-MMU-429958 mRNA decay by 3' to 5' exoribonuclease 0.956601266388048 -0.0443686238939906 16 2 0.000846740050804403 2362 8688 69305,68106 Dcps,Nt5c3b R-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI) 0.956601266388048 -0.0443686238939906 16 2 0.000846740050804403 2362 8688 230801,27392 Pigv,Pign R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA 0.956601266388048 -0.0443686238939906 16 2 0.000846740050804403 2362 8688 22190,69807 Ubc,Trim32 R-MMU-1300642 Sperm Motility And Taxes 0.958192603279509 -0.0427064739539458 10 1 0.000423370025402202 2362 8688 74096 Hvcn1 R-MMU-110357 Displacement of DNA glycosylase by APEX1 0.958192603279509 -0.0427064739539458 10 1 0.000423370025402202 2362 8688 18294 Ogg1 R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs 0.958192603279509 -0.0427064739539458 10 1 0.000423370025402202 2362 8688 20643 Snrpe R-MMU-3215018 Processing and activation of SUMO 0.958192603279509 -0.0427064739539458 10 1 0.000423370025402202 2362 8688 66568 Rwdd3 R-MMU-71336 Pentose phosphate pathway (hexose monophosphate shunt) 0.958192603279509 -0.0427064739539458 10 1 0.000423370025402202 2362 8688 19895 Rpia R-MMU-1855167 Synthesis of pyrophosphates in the cytosol 0.958192603279509 -0.0427064739539458 10 1 0.000423370025402202 2362 8688 271424 Ip6k3 R-MMU-196849 Metabolism of water-soluble vitamins and cofactors 0.958621828873975 -0.042258620896874 112 23 0.00973751058425064 2362 8688 19223,110821,109754,18605,216134,93835,67375,107747,270685,226518,68214,54338,14104,17768,65969,59027,56738,17434,18563,23959,18113,20525,66812 Ptgis,Pcca,Cyb5r3,Enpp1,Pdxk,Amn,Qprt,Aldh1l1,Mthfd1l,Nmnat2,Gsto2,Slc23a2,Fasn,Mthfd2,Cubn,Nampt,Mocs1,Mocs2,Pcx,Nt5e,Nnmt,Slc2a1,Ppcdc R-MMU-194441 Metabolism of non-coding RNA 0.960083692612923 -0.0407348185150649 51 9 0.00381033022861981 2362 8688 218210,20643,54563,53975,72787,227720,69482,12729,71805 Nup153,Snrpe,Nup210,Ddx20,Ndc1,Nup214,Nup35,Clns1a,Nup93 R-MMU-191859 snRNP Assembly 0.960083692612923 -0.0407348185150649 51 9 0.00381033022861981 2362 8688 218210,54563,20643,72787,53975,227720,69482,12729,71805 Nup153,Nup210,Snrpe,Ndc1,Ddx20,Nup214,Nup35,Clns1a,Nup93 R-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.961645365710135 -0.039109538994817 22 3 0.0012701100762066 2362 8688 15107,52538,110821 Hadh,Acaa2,Pcca R-MMU-1474165 Reproduction 0.961645365710135 -0.039109538994817 22 3 0.0012701100762066 2362 8688 71078,12527,74096 Adam30,Cd9,Hvcn1 R-MMU-1187000 Fertilization 0.961645365710135 -0.039109538994817 22 3 0.0012701100762066 2362 8688 74096,71078,12527 Hvcn1,Adam30,Cd9 R-MMU-5617833 Cilium Assembly 0.965144266570449 -0.0354776897802834 168 36 0.0152413209144793 2362 8688 215445,68642,53869,12534,18763,16579,333329,381644,319845,13196,21821,68146,213081,52906,76260,238799,382090,214444,12589,18536,212541,260305,13589,99100,214552,72938,26920,18005,64436,73738,74682,73916,67068,19088,75465,16559 Rab11fip3,Tmem216,Rab11a,Cdk1,Pkd1,Kifap3,Cngb1,Cep135,Bbs9,Asap1,Ift88,Arl13b,Wdr19,Ahi1,Ttc8,Tnpo1,Cep162,Cdk5rap2,Ift81,Pcm1,Rho,Nphp4,Mapre1,Cep152,Cep164,Hspb11,Cntrl,Nek2,Inpp5e,Haus7,Wdr35,Ift57,Dynlrb1,Prkar2b,Dynlrb2,Kif17 R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.96525225896506 -0.0353658035503877 61 11 0.00465707027942422 2362 8688 19687,22190,67439,13871,69263,71101,12572,67967,27015,16881,68275 Rfc1,Ubc,Xab2,Ercc2,Rfc3,Uvssa,Cdk7,Pold3,Polk,Lig1,Rpa1 R-MMU-5358346 Hedgehog ligand biogenesis 0.96525225896506 -0.0353658035503877 61 11 0.00465707027942422 2362 8688 66998,22190,226861,19167,66413,66997,19177,103554,17463,26440,26443 Psmd5,Ubc,Hhat,Psma3,Psmd6,Psmd12,Psmb7,Psme4,Psmd7,Psma1,Psma6 R-MMU-5423646 Aflatoxin activation and detoxification 0.966726044605808 -0.0338401281078636 17 2 0.000846740050804403 2362 8688 71670,211666 Acy3,Mgst2 R-MMU-427359 SIRT1 negatively regulates rRNA Expression 0.967587882673262 -0.0329490233990255 38 6 0.00254022015241321 2362 8688 15081,21340,15078,97122,319161,97114 H3f3b,Taf1b,H3f3a,Hist2h4,Hist1h4n,Hist2h3c2 R-MMU-75067 Processing of Capped Intronless Pre-mRNA 0.967668485792938 -0.0328657237173547 28 4 0.00169348010160881 2362 8688 18789,20643,269061,228410 Papola,Snrpe,Cpsf7,Cstf3 R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.967668485792938 -0.0328657237173547 28 4 0.00169348010160881 2362 8688 12572,20924,13871,68705 Cdk7,Supt5,Ercc2,Gtf2f2 R-MMU-6803529 FGFR2 alternative splicing 0.967668485792938 -0.0328657237173547 28 4 0.00169348010160881 2362 8688 68705,19205,207920,93686 Gtf2f2,Ptbp1,Esrp1,Rbfox2 R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes 0.96788086766682 -0.0326462698714953 75 14 0.00592718035563082 2362 8688 18536,12534,103768,214552,13589,259279,99100,381644,214444,18005,26920,51885,73738,19088 Pcm1,Cdk1,Tubg2,Cep164,Mapre1,Tubgcp3,Cep152,Cep135,Cdk5rap2,Nek2,Cntrl,Tubgcp4,Haus7,Prkar2b R-MMU-380287 Centrosome maturation 0.96788086766682 -0.0326462698714953 75 14 0.00592718035563082 2362 8688 103768,259279,99100,13589,214552,18536,12534,73738,19088,18005,26920,214444,381644,51885 Tubg2,Tubgcp3,Cep152,Mapre1,Cep164,Pcm1,Cdk1,Haus7,Prkar2b,Nek2,Cntrl,Cdk5rap2,Cep135,Tubgcp4 R-MMU-69206 G1/S Transition 0.968339130396909 -0.0321729117416292 110 22 0.00931414055884843 2362 8688 12572,26440,66413,19167,22390,22190,12544,66998,18974,26443,19076,17463,19177,12534,18968,66997,12447,68275,12545,13555,12443,17217 Cdk7,Psma1,Psmd6,Psma3,Wee1,Ubc,Cdc45,Psmd5,Pole2,Psma6,Prim2,Psmd7,Psmb7,Cdk1,Pola1,Psmd12,Ccne1,Rpa1,Cdc7,E2f1,Ccnd1,Mcm4 R-MMU-68689 CDC6 association with the ORC:origin complex 0.969571846306394 -0.0309007004888229 11 1 0.000423370025402202 2362 8688 13555 E2f1 R-MMU-73929 Base-Excision Repair, AP Site Formation 0.969571846306394 -0.0309007004888229 11 1 0.000423370025402202 2362 8688 18294 Ogg1 R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.969571846306394 -0.0309007004888229 11 1 0.000423370025402202 2362 8688 20643 Snrpe R-MMU-189451 Heme biosynthesis 0.969571846306394 -0.0309007004888229 11 1 0.000423370025402202 2362 8688 14151 Fech R-MMU-933541 TRAF6 mediated IRF7 activation 0.969772331496565 -0.030693944830719 23 3 0.0012701100762066 2362 8688 72162,16363,15977 Dhx36,Irf2,Ifnb1 R-MMU-6782135 Dual incision in TC-NER 0.970294147568306 -0.0301560085383755 62 11 0.00465707027942422 2362 8688 71101,12572,67967,27015,13870,68275,19687,22190,67439,13871,69263 Uvssa,Cdk7,Pold3,Polk,Ercc1,Rpa1,Rfc1,Ubc,Xab2,Ercc2,Rfc3 R-MMU-453279 Mitotic G1-G1/S phases 0.970774651855985 -0.0296609160433169 132 27 0.0114309906858594 2362 8688 12443,17217,13555,12571,18968,66997,68275,12545,12447,12534,19177,13548,17463,18974,19076,26443,66998,12544,21973,22190,71978,19167,22390,66413,12579,26440,12572 Ccnd1,Mcm4,E2f1,Cdk6,Pola1,Psmd12,Rpa1,Cdc7,Ccne1,Cdk1,Psmb7,Dyrk1a,Psmd7,Pole2,Prim2,Psma6,Psmd5,Cdc45,Top2a,Ubc,Ppp2r2a,Psma3,Wee1,Psmd6,Cdkn2b,Psma1,Cdk7 R-MMU-69239 Synthesis of DNA 0.971966120477952 -0.0284343306045221 98 19 0.00804403048264183 2362 8688 19177,68275,16881,18968,66997,26443,19076,18974,17463,17217,103554,66413,26440,67967,66998,69263,19167,19687,22190 Psmb7,Rpa1,Lig1,Pola1,Psmd12,Psma6,Prim2,Pole2,Psmd7,Mcm4,Psme4,Psmd6,Psma1,Pold3,Psmd5,Rfc3,Psma3,Rfc1,Ubc R-MMU-68867 Assembly of the pre-replicative complex 0.972282044132953 -0.0281093477514771 67 12 0.00508044030482642 2362 8688 26440,17463,26443,66997,66413,103554,19177,22190,13555,19167,66998,17217 Psma1,Psmd7,Psma6,Psmd12,Psmd6,Psme4,Psmb7,Ubc,E2f1,Psma3,Psmd5,Mcm4 R-MMU-73894 DNA Repair 0.973007776373873 -0.0273632046658151 269 60 0.0254022015241321 2362 8688 55982,232314,68275,107976,16881,19360,13870,225182,59047,101831,11545,18294,230484,225280,68098,67196,108679,14088,19363,70620,223970,27015,67030,12144,12572,69263,18970,26430,26419,22190,16647,11350,227525,17535,51869,27223,319161,71101,14048,14087,22230,97122,22596,19356,319583,227195,68142,11461,12021,14049,330554,54125,67967,26383,56469,13871,19359,15574,67439,19687 Paxip1,Ppp4r2,Rpa1,Babam2,Lig1,Rad50,Ercc1,Rbbp8,Pnkp,Faap24,Parp1,Ogg1,Usp1,Ino80c,Rchy1,Ube2t,Cops8,Fancc,Rad51b,Ube2v2,Rmi2,Polk,Fancl,Blm,Cdk7,Rfc3,Polb,Parg,Mapk8,Ubc,Kpna2,Abl1,Dclre1c,Mre11a,Rif1,Trp53bp1,Hist1h4n,Uvssa,Eya1,Fanca,Ufd1,Hist2h4,Xrcc5,Rad17,Lig4,Ino80d,Ino80,Actb,Bard1,Eya2,Fan1,Polm,Pold3,Fto,Pias1,Ercc2,Rad23b,Hus1,Xab2,Rfc1 R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.973044009423586 -0.0273259671678399 58 10 0.00423370025402202 2362 8688 26443,17463,26440,103554,19177,66997,66413,19167,22190,66998 Psma6,Psmd7,Psma1,Psme4,Psmb7,Psmd12,Psmd6,Psma3,Ubc,Psmd5 R-MMU-5676590 NIK-->noncanonical NF-kB signaling 0.973044009423586 -0.0273259671678399 58 10 0.00423370025402202 2362 8688 26443,17463,26440,103554,19177,66413,66997,19167,22190,66998 Psma6,Psmd7,Psma1,Psme4,Psmb7,Psmd6,Psmd12,Psma3,Ubc,Psmd5 R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex 0.973044009423586 -0.0273259671678399 58 10 0.00423370025402202 2362 8688 66998,19167,22190,103554,19177,66413,66997,26443,17463,26440 Psmd5,Psma3,Ubc,Psme4,Psmb7,Psmd6,Psmd12,Psma6,Psmd7,Psma1 R-MMU-5689901 Metalloprotease DUBs 0.973263911747745 -0.027099998478402 34 5 0.00211685012701101 2362 8688 107976,12021,22190,18519,109359 Babam2,Bard1,Ubc,Kat2b,Abraxas2 R-MMU-189445 Metabolism of porphyrins 0.974555714473981 -0.0257735892993984 18 2 0.000846740050804403 2362 8688 15369,14151 Hmox2,Fech R-MMU-163210 Formation of ATP by chemiosmotic coupling 0.974555714473981 -0.0257735892993984 18 2 0.000846740050804403 2362 8688 28080,11957 Atp5o,Atp5j R-MMU-71384 Ethanol oxidation 0.977854812685715 -0.02239407325419 12 1 0.000423370025402202 2362 8688 11669 Aldh2 R-MMU-71182 Phenylalanine and tyrosine catabolism 0.977854812685715 -0.02239407325419 12 1 0.000423370025402202 2362 8688 66514 Asrgl1 R-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.977854812685715 -0.02239407325419 12 1 0.000423370025402202 2362 8688 16906 Lmnb1 R-MMU-622323 Presynaptic nicotinic acetylcholine receptors 0.977854812685715 -0.02239407325419 12 1 0.000423370025402202 2362 8688 108043 Chrnb3 R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.978010325396039 -0.0222350513383903 143 29 0.0122777307366638 2362 8688 269951,381511,20917,27402,228026,22228,20181,28080,20916,69487,76947,110842,18115,68263,11957,68194,106557,20501,22227,78920,56451,71832,11429,68375,17993,80879,76826,67680,16828 Idh2,Pdp1,Suclg2,Pdhx,Pdk1,Ucp2,Rxra,Atp5o,Sucla2,Ndufaf5,Ndufaf6,Etfa,Nnt,Pdhb,Atp5j,Ndufb4,Ldhal6b,Slc16a1,Ucp1,Dlst,Suclg1,Csl,Aco2,Ndufa8,Ndufs4,Slc16a3,Nubpl,Sdhb,Ldha R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.979274498444652 -0.0209432891901291 30 4 0.00169348010160881 2362 8688 233863,66596,269252,20018 Gtf3c1,Gtf3a,Gtf3c4,Polr1d R-MMU-72086 mRNA Capping 0.979274498444652 -0.0209432891901291 30 4 0.00169348010160881 2362 8688 12572,68705,13871,20924 Cdk7,Gtf2f2,Ercc2,Supt5 R-MMU-912446 Meiotic recombination 0.980589325337949 -0.0196015356717478 19 2 0.000846740050804403 2362 8688 68275,12144 Rpa1,Blm R-MMU-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.981000782381394 -0.0191820218825418 74 13 0.00550381033022862 2362 8688 13871,69263,19687,108679,22190,67439,27015,13870,68275,16881,12572,71101,67967 Ercc2,Rfc3,Rfc1,Cops8,Ubc,Xab2,Polk,Ercc1,Rpa1,Lig1,Cdk7,Uvssa,Pold3 R-MMU-774815 Nucleosome assembly 0.982063051430535 -0.0180997655294587 41 6 0.00254022015241321 2362 8688 97122,319161,52504,66336,93762,66311 Hist2h4,Hist1h4n,Cenpo,Cenpp,Smarca5,Cenpw R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.982063051430535 -0.0180997655294587 41 6 0.00254022015241321 2362 8688 66336,93762,66311,97122,319161,52504 Cenpp,Smarca5,Cenpw,Hist2h4,Hist1h4n,Cenpo R-MMU-73777 RNA Polymerase I Chain Elongation 0.983478439955079 -0.016659563147168 31 4 0.00169348010160881 2362 8688 13871,21340,12572,20018 Ercc2,Taf1b,Cdk7,Polr1d R-MMU-977441 GABA A receptor activation 0.983883735275502 -0.0162475441185833 13 1 0.000423370025402202 2362 8688 14407 Gabrg3 R-MMU-2151201 Transcriptional activation of mitochondrial biogenesis 0.983883735275502 -0.0162475441185833 13 1 0.000423370025402202 2362 8688 19017 Ppargc1a R-MMU-73854 RNA Polymerase I Promoter Clearance 0.984756207714027 -0.0153611733032864 80 14 0.00592718035563082 2362 8688 15182,97114,13871,97122,20018,21340,18519,17191,319161,12572,15078,26417,234366,15081 Hdac2,Hist2h3c2,Ercc2,Hist2h4,Polr1d,Taf1b,Kat2b,Mbd2,Hist1h4n,Cdk7,H3f3a,Mapk3,Gatad2a,H3f3b R-MMU-977606 Regulation of Complement cascade 0.985460187724062 -0.0146465512530139 26 3 0.0012701100762066 2362 8688 12279,110382,12509 C9,C8b,Cd59a R-MMU-5578749 Transcriptional regulation by small RNAs 0.986133506978944 -0.013963530930047 76 13 0.00550381033022862 2362 8688 15078,218210,15081,319161,72787,239528,54563,227720,69482,233833,71805,97114,97122 H3f3a,Nup153,H3f3b,Hist1h4n,Ndc1,Ago2,Nup210,Nup214,Nup35,Tnrc6a,Nup93,Hist2h3c2,Hist2h4 R-MMU-983169 Class I MHC mediated antigen processing & presentation 0.986577809853537 -0.0135130819684432 215 45 0.0190516511430991 2362 8688 17969,103554,16419,20437,12449,16410,224826,50764,66998,99683,72194,74646,110379,380928,268291,74165,244421,19167,207215,83814,66997,101358,19177,17463,26443,320118,66397,66663,218203,67845,66413,218215,26440,226098,75234,76454,19155,12491,22190,19647,50754,387524,230904,74244,30838 Ncf1,Psme4,Itgb5,Siah1a,Ccnf,Itgav,Ubr2,Fbxo15,Psmd5,Sec24b,Fbxl20,Spsb1,Sec13,Lmo7,Rnf217,Fbxl22,Lonrf1,Psma3,Fbxo40,Nedd4l,Psmd12,Fbxl14,Psmb7,Psmd7,Psma6,Fbxl13,Sar1b,Uba5,Mylip,Rnf115,Psmd6,Rnf144b,Psma1,Hectd2,Rnf19b,Fbxo31,Npepps,Cd36,Ubc,Rbbp6,Fbxw7,Znrf2,Fbxo2,Atg7,Fbxw4 R-MMU-1170546 Prolactin receptor signaling 0.986865044756147 -0.0132219816672942 32 4 0.00169348010160881 2362 8688 19109,16452,19116,14600 Prl,Jak2,Prlr,Ghr R-MMU-73772 RNA Polymerase I Promoter Escape 0.986865044756147 -0.0132219816672942 32 4 0.00169348010160881 2362 8688 13871,12572,20018,21340 Ercc2,Cdk7,Polr1d,Taf1b R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.986912365004548 -0.0131740327464321 67 11 0.00465707027942422 2362 8688 381644,18005,26920,214444,19088,73738,12534,18536,13589,99100,214552 Cep135,Nek2,Cntrl,Cdk5rap2,Prkar2b,Haus7,Cdk1,Pcm1,Mapre1,Cep152,Cep164 R-MMU-380259 Loss of Nlp from mitotic centrosomes 0.986912365004548 -0.0131740327464321 67 11 0.00465707027942422 2362 8688 12534,18536,99100,13589,214552,18005,214444,381644,26920,19088,73738 Cdk1,Pcm1,Cep152,Mapre1,Cep164,Nek2,Cdk5rap2,Cep135,Cntrl,Prkar2b,Haus7 R-MMU-73864 RNA Polymerase I Transcription 0.986948720158427 -0.0131371961583289 81 14 0.00592718035563082 2362 8688 15081,234366,26417,12572,15078,319161,17191,18519,21340,20018,97122,13871,15182,97114 H3f3b,Gatad2a,Mapk3,Cdk7,H3f3a,Hist1h4n,Mbd2,Kat2b,Taf1b,Polr1d,Hist2h4,Ercc2,Hdac2,Hist2h3c2 R-MMU-2142753 Arachidonic acid metabolism 0.98753955196641 -0.0125387303847323 72 12 0.00508044030482642 2362 8688 17001,230639,18783,66469,622402,11690,11686,21391,18979,19223,19224,13109 Ltc4s,Cyp4a29,Pla2g4a,Prxl2b,Akr1c12,Alox5ap,Alox12b,Tbxas1,Pon1,Ptgis,Ptgs1,Cyp2j5 R-MMU-73762 RNA Polymerase I Transcription Initiation 0.987888868307186 -0.0121850690312437 48 7 0.00296359017781541 2362 8688 234366,20018,12572,21340,18519,13871,15182 Gatad2a,Polr1d,Cdk7,Taf1b,Kat2b,Ercc2,Hdac2 R-MMU-391903 Eicosanoid ligand-binding receptors 0.988271817958265 -0.0117974996817122 14 1 0.000423370025402202 2362 8688 19220 Ptgfr R-MMU-74158 RNA Polymerase III Transcription 0.988596862568545 -0.0114686517249302 38 5 0.00211685012701101 2362 8688 20018,75627,269252,66596,233863 Polr1d,Snapc1,Gtf3c4,Gtf3a,Gtf3c1 R-MMU-76046 RNA Polymerase III Transcription Initiation 0.988596862568545 -0.0114686517249302 38 5 0.00211685012701101 2362 8688 75627,269252,20018,233863,66596 Snapc1,Gtf3c4,Polr1d,Gtf3c1,Gtf3a R-MMU-69278 Cell Cycle, Mitotic 0.989352561005812 -0.0107045285729119 438 99 0.041913632514818 2362 8688 21973,12544,21664,18005,69263,26920,208628,73738,72787,52696,17120,66413,12572,26417,26440,51885,226747,217718,214444,14245,26931,229776,52504,18536,16881,22367,18974,99100,59021,66977,66336,56430,216080,19687,16319,67121,18751,71978,103768,71805,17217,97122,227720,108000,13555,319161,66997,18968,259279,71782,26443,236930,69482,19088,22190,67629,13000,18750,320595,15516,26932,244329,16905,268930,12447,100710,54563,68275,67956,13589,56150,19076,214552,19357,110379,66998,381644,19167,77805,22390,72415,103554,12579,76499,71521,68999,22194,67967,218210,107995,12443,59126,12571,12534,83431,19177,12545,13548,17463 Top2a,Cdc45,Phlda1,Nek2,Rfc3,Cntrl,Kntc1,Haus7,Ndc1,Zwint,Mad1l1,Psmd6,Cdk7,Mapk3,Psma1,Tubgcp4,Ahctf1,Nek9,Cdk5rap2,Lpin1,Ppp2r5c,Cdc14a,Cenpo,Pcm1,Lig1,Vrk1,Pole2,Cep152,Rab2a,Nuf2,Cenpp,Clip1,Ube2d1,Rfc1,Incenp,Mastl,Prkcb,Ppp2r2a,Tubg2,Nup93,Mcm4,Hist2h4,Nup214,Cenpf,E2f1,Hist1h4n,Psmd12,Pola1,Tubgcp3,Ankle2,Psma6,Ercc6l,Nup35,Prkar2b,Ubc,Spc24,Csnk2a2,Prkca,Phf8,Hsp90ab1,Ppp2r5e,Mcph1,Lmna,Pkmyt1,Ccne1,Pds5b,Nup210,Rpa1,Kmt5a,Mapre1,Mad2l1,Prim2,Cep164,Rad21,Sec13,Psmd5,Cep135,Psma3,Esco1,Wee1,Sgo1,Psme4,Cdkn2b,Clasp2,Pds5a,Anapc10,Ube2e1,Pold3,Nup153,Cdc20,Ccnd1,Nek6,Cdk6,Cdk1,Ndel1,Psmb7,Cdc7,Dyrk1a,Psmd7 R-MMU-73863 RNA Polymerase I Transcription Termination 0.989583999078992 -0.0104706271140135 33 4 0.00169348010160881 2362 8688 20018,12572,21340,13871 Polr1d,Cdk7,Taf1b,Ercc2 R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence 0.990310921812436 -0.00973632272398138 44 6 0.00254022015241321 2362 8688 17535,97122,12447,16906,19360,319161 Mre11a,Hist2h4,Ccne1,Lmnb1,Rad50,Hist1h4n R-MMU-194002 Glucocorticoid biosynthesis 0.991465496313614 -0.00857113110978564 15 1 0.000423370025402202 2362 8688 18976 Pomc R-MMU-674695 RNA Polymerase II Pre-transcription Events 0.9914851395029 -0.00855131902880707 79 13 0.00550381033022862 2362 8688 235497,68705,13871,13716,68153,74427,67655,72949,20924,70122,83602,12572,24116 Leo1,Gtf2f2,Ercc2,Ell,Gtf2e2,Eaf1,Ctdp1,Ccnt2,Supt5,Mllt3,Gtf2a1,Cdk7,Nelfa R-MMU-975298 Ligand-gated ion channel transport 0.991487859525692 -0.00854857565026056 22 2 0.000846740050804403 2362 8688 14407,14658 Gabrg3,Glrb R-MMU-1679131 Trafficking and processing of endosomal TLR 0.991487859525692 -0.00854857565026056 22 2 0.000846740050804403 2362 8688 13030,218275 Ctsb,BC051665 R-MMU-5620912 Anchoring of the basal body to the plasma membrane 0.991540827714028 -0.00849515414537733 93 16 0.00677392040643522 2362 8688 382090,19088,52906,73738,381644,26920,18005,214552,13589,99100,260305,12534,18536,53869,214444,68642 Cep162,Prkar2b,Ahi1,Haus7,Cep135,Cntrl,Nek2,Cep164,Mapre1,Cep152,Nphp4,Cdk1,Pcm1,Rab11a,Cdk5rap2,Tmem216 R-MMU-8854518 AURKA Activation by TPX2 0.99220576724992 -0.00782476654397433 70 11 0.00465707027942422 2362 8688 99100,13589,214552,12534,18536,19088,73738,381644,18005,26920,214444 Cep152,Mapre1,Cep164,Cdk1,Pcm1,Prkar2b,Haus7,Cep135,Nek2,Cntrl,Cdk5rap2 R-MMU-69052 Switching of origins to a post-replicative state 0.99220576724992 -0.00782476654397433 70 11 0.00465707027942422 2362 8688 66998,17217,19167,22190,103554,19177,66997,66413,26443,17463,26440 Psmd5,Mcm4,Psma3,Ubc,Psme4,Psmb7,Psmd12,Psmd6,Psma6,Psmd7,Psma1 R-MMU-68949 Orc1 removal from chromatin 0.99220576724992 -0.00782476654397433 70 11 0.00465707027942422 2362 8688 22190,19167,66998,17217,26440,17463,26443,66413,66997,103554,19177 Ubc,Psma3,Psmd5,Mcm4,Psma1,Psmd7,Psma6,Psmd6,Psmd12,Psme4,Psmb7 R-MMU-69304 Regulation of DNA replication 0.992481190135013 -0.00754721860540792 75 12 0.00508044030482642 2362 8688 19167,13555,22190,66998,17217,26443,17463,26440,103554,19177,66997,66413 Psma3,E2f1,Ubc,Psmd5,Mcm4,Psma6,Psmd7,Psma1,Psme4,Psmb7,Psmd12,Psmd6 R-MMU-5689603 UCH proteinases 0.992756993525478 -0.0072693643967696 94 16 0.00677392040643522 2362 8688 26440,103554,12021,66413,11461,19167,22190,66998,26443,17425,17463,19177,66997,227195,68142,225280 Psma1,Psme4,Bard1,Psmd6,Actb,Psma3,Ubc,Psmd5,Psma6,Foxk1,Psmd7,Psmb7,Psmd12,Ino80d,Ino80,Ino80c R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.993160871104799 -0.00686262291759602 29 3 0.0012701100762066 2362 8688 233863,269252,20018 Gtf3c1,Gtf3c4,Polr1d R-MMU-3214842 HDMs demethylate histones 0.993363730609791 -0.00665838733398186 51 7 0.00296359017781541 2362 8688 216850,338523,97122,320595,319161,77035,97114 Kdm6b,Kdm7a,Hist2h4,Phf8,Hist1h4n,Kdm8,Hist2h3c2 R-MMU-166663 Initial triggering of complement 0.993789778322237 -0.00622958531435044 16 1 0.000423370025402202 2362 8688 239447 Colec10 R-MMU-69300 Removal of licensing factors from origins 0.994538379680464 -0.00547658949664712 72 11 0.00465707027942422 2362 8688 26443,17463,26440,19177,103554,66413,66997,19167,22190,66998,17217 Psma6,Psmd7,Psma1,Psmb7,Psme4,Psmd6,Psmd12,Psma3,Ubc,Psmd5,Mcm4 R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 0.995129273299671 -0.00488262734855242 24 2 0.000846740050804403 2362 8688 65969,93835 Cubn,Amn R-MMU-390522 Striated Muscle Contraction 0.995906518690488 -0.00410188253881602 31 3 0.0012701100762066 2362 8688 59069,21956,13346 Tpm3,Tnnt2,Des R-MMU-453274 Mitotic G2-G2/M phases 0.996634039330542 -0.0033716382590143 167 31 0.0131244707874682 2362 8688 66413,103554,103768,26440,12572,66998,381644,26920,18005,21664,71978,73738,22190,22390,19088,19167,66997,18536,268930,19177,12534,17463,26443,214552,13589,99100,259279,15516,214444,51885,13555 Psmd6,Psme4,Tubg2,Psma1,Cdk7,Psmd5,Cep135,Cntrl,Nek2,Phlda1,Ppp2r2a,Haus7,Ubc,Wee1,Prkar2b,Psma3,Psmd12,Pcm1,Pkmyt1,Psmb7,Cdk1,Psmd7,Psma6,Cep164,Mapre1,Cep152,Tubgcp3,Hsp90ab1,Cdk5rap2,Tubgcp4,E2f1 R-MMU-3214858 RMTs methylate histone arginines 0.996834817045982 -0.00317020274074471 70 10 0.00423370025402202 2362 8688 57376,97122,12443,97114,140858,67155,20588,66993,13435,319161 Smarce1,Hist2h4,Ccnd1,Hist2h3c2,Wdr5,Smarca2,Smarcc1,Smarcd3,Dnmt3a,Hist1h4n R-MMU-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.997198597474972 -0.00280533379684848 114 19 0.00804403048264183 2362 8688 17191,319161,15078,75627,97114,97122,20018,21340,66596,233863,12572,26417,234366,15081,15182,13871,208595,18519,269252 Mbd2,Hist1h4n,H3f3a,Snapc1,Hist2h3c2,Hist2h4,Polr1d,Taf1b,Gtf3a,Gtf3c1,Cdk7,Mapk3,Gatad2a,H3f3b,Hdac2,Ercc2,Mterf1b,Kat2b,Gtf3c4 R-MMU-211000 Gene Silencing by RNA 0.997362233429486 -0.00264125160657787 105 17 0.00719729043183743 2362 8688 83561,69482,14000,72787,239528,15081,218210,213988,97122,71805,83456,97114,233833,227720,54563,319161,15078 Tdrd1,Nup35,Drosha,Ndc1,Ago2,H3f3b,Nup153,Tnrc6b,Hist2h4,Nup93,Mov10l1,Hist2h3c2,Tnrc6a,Nup214,Nup210,Hist1h4n,H3f3a R-MMU-72202 Transport of Mature Transcript to Cytoplasm 0.997386571606837 -0.00261684935874554 71 10 0.00423370025402202 2362 8688 66118,66231,71805,51796,69482,227720,72787,54563,56488,218210 Sarnp,Thoc7,Nup93,Srrm1,Nup35,Nup214,Ndc1,Nup210,Nxt1,Nup153 R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.997386571606837 -0.00261684935874554 71 10 0.00423370025402202 2362 8688 51796,227720,69482,66118,66231,71805,218210,54563,56488,72787 Srrm1,Nup214,Nup35,Sarnp,Thoc7,Nup93,Nup153,Nup210,Nxt1,Ndc1 R-MMU-166658 Complement cascade 0.997527677470728 -0.00247538376523192 39 4 0.00169348010160881 2362 8688 239447,12279,110382,12509 Colec10,C9,C8b,Cd59a R-MMU-69275 G2/M Transition 0.997566110635084 -0.00243685608839865 165 30 0.012701100762066 2362 8688 214444,15516,51885,17463,259279,99100,13589,214552,26443,268930,66997,18536,19177,12534,22190,71978,73738,19167,22390,19088,18005,381644,66998,26920,21664,103768,26440,12572,66413,103554 Cdk5rap2,Hsp90ab1,Tubgcp4,Psmd7,Tubgcp3,Cep152,Mapre1,Cep164,Psma6,Pkmyt1,Psmd12,Pcm1,Psmb7,Cdk1,Ubc,Ppp2r2a,Haus7,Psma3,Wee1,Prkar2b,Nek2,Cep135,Psmd5,Cntrl,Phlda1,Tubg2,Psma1,Cdk7,Psmd6,Psme4 R-MMU-75953 RNA Polymerase II Transcription Initiation 0.998147279923766 -0.00185443848488897 46 5 0.00211685012701101 2362 8688 68705,13871,83602,12572,68153 Gtf2f2,Ercc2,Gtf2a1,Cdk7,Gtf2e2 R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.998147279923766 -0.00185443848488897 46 5 0.00211685012701101 2362 8688 13871,68705,83602,12572,68153 Ercc2,Gtf2f2,Gtf2a1,Cdk7,Gtf2e2 R-MMU-73776 RNA Polymerase II Promoter Escape 0.998147279923766 -0.00185443848488897 46 5 0.00211685012701101 2362 8688 12572,68153,83602,68705,13871 Cdk7,Gtf2e2,Gtf2a1,Gtf2f2,Ercc2 R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.998147279923766 -0.00185443848488897 46 5 0.00211685012701101 2362 8688 13871,68705,12572,68153,83602 Ercc2,Gtf2f2,Cdk7,Gtf2e2,Gtf2a1 R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition 0.998505549933165 -0.00149556787114339 84 12 0.00508044030482642 2362 8688 19088,73738,22190,26920,18005,381644,214444,214552,99100,13589,12534,18536 Prkar2b,Haus7,Ubc,Cntrl,Nek2,Cep135,Cdk5rap2,Cep164,Cep152,Mapre1,Cdk1,Pcm1 R-MMU-211897 Cytochrome P450 - arranged by substrate type 0.998560676882863 -0.00144035993765421 99 15 0.00635055038103302 2362 8688 20181,11622,230639,18976,11864,21391,13124,232174,19223,14148,13070,13120,13082,14149,13109 Rxra,Ahr,Cyp4a29,Pomc,Arnt2,Tbxas1,Cyp8b1,Cyp26b1,Ptgis,Fdx1,Cyp11a1,Cyp4b1,Cyp26a1,Fdxr,Cyp2j5 R-MMU-1592389 Activation of Matrix Metalloproteinases 0.998846098118746 -0.00115456813860924 48 5 0.00211685012701101 2362 8688 17389,17386,21858,18550,17393 Mmp16,Mmp13,Timp2,Furin,Mmp7 R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.998846098118746 -0.00115456813860924 48 5 0.00211685012701101 2362 8688 20090,267019,56347,68135,98221 Rps29,Rps15a,Eif3c,Eif3h,Eif3m R-MMU-6781823 Formation of TC-NER Pre-Incision Complex 0.9989205044281 -0.0010800786469004 54 6 0.00254022015241321 2362 8688 13871,71101,12572,108679,67439,22190 Ercc2,Uvssa,Cdk7,Cops8,Xab2,Ubc R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.999116143079922 -0.000884247751915709 30 2 0.000846740050804403 2362 8688 75627,20018 Snapc1,Polr1d R-MMU-72187 mRNA 3'-end processing 0.999141883768897 -0.000858484623599746 55 6 0.00254022015241321 2362 8688 66231,66118,269061,228410,51796,18789 Thoc7,Sarnp,Cpsf7,Cstf3,Srrm1,Papola R-MMU-72702 Ribosomal scanning and start codon recognition 0.999141883768897 -0.000858484623599746 55 6 0.00254022015241321 2362 8688 98221,68135,267019,56347,217869,20090 Eif3m,Eif3h,Rps15a,Eif3c,Eif5,Rps29 R-MMU-4839726 Chromatin organization 0.999192109248565 -0.000808217271040973 191 34 0.0143945808636749 2362 8688 18033,226830,228829,381022,52690,12443,97122,18600,319161,225888,14013,54343,77035,66083,20588,338523,216850,18599,69726,97114,320595,15078,77683,11569,13435,67956,57376,18505,140858,28019,54169,67155,15081,66993 Nfkb1,Smyd2,Phf20,Kmt2d,Setd3,Ccnd1,Hist2h4,Padi2,Hist1h4n,Kmt5b,Mecom,Atf7ip,Kdm8,Setd6,Smarcc1,Kdm7a,Kdm6b,Padi1,Smyd3,Hist2h3c2,Phf8,H3f3a,Ehmt1,Aebp2,Dnmt3a,Kmt5a,Smarce1,Pax3,Wdr5,Ing4,Kat6b,Smarca2,H3f3b,Smarcd3 R-MMU-3247509 Chromatin modifying enzymes 0.999192109248565 -0.000808217271040973 191 34 0.0143945808636749 2362 8688 216850,338523,20588,18599,66083,77035,18600,54343,14013,319161,225888,381022,228829,226830,18033,97122,12443,52690,15081,67155,66993,18505,57376,54169,140858,28019,15078,67956,13435,11569,77683,69726,320595,97114 Kdm6b,Kdm7a,Smarcc1,Padi1,Setd6,Kdm8,Padi2,Atf7ip,Mecom,Hist1h4n,Kmt5b,Kmt2d,Phf20,Smyd2,Nfkb1,Hist2h4,Ccnd1,Setd3,H3f3b,Smarca2,Smarcd3,Pax3,Smarce1,Kat6b,Wdr5,Ing4,H3f3a,Kmt5a,Dnmt3a,Aebp2,Ehmt1,Smyd3,Phf8,Hist2h3c2 R-MMU-3214847 HATs acetylate histones 0.99920090082166 -0.000799418628281334 77 10 0.00423370025402202 2362 8688 319161,15081,15078,97122,54169,28019,140858,97114,18505,228829 Hist1h4n,H3f3b,H3f3a,Hist2h4,Kat6b,Ing4,Wdr5,Hist2h3c2,Pax3,Phf20 R-MMU-1852241 Organelle biogenesis and maintenance 0.999313245945266 -0.000686989978320609 276 53 0.0224386113463167 2362 8688 232536,241113,16559,75465,72938,26920,18005,64436,68565,74682,73738,73916,19088,19017,52443,67068,212541,18536,260305,214552,13589,99100,214444,60441,66230,56280,12589,76260,64656,108099,26416,238799,382090,26415,381644,333329,319845,21821,68146,13196,59054,52906,213081,68537,66845,12534,18763,16579,68642,215445,53869,108079,94062 Mrps35,Prkag3,Kif17,Dynlrb2,Hspb11,Cntrl,Nek2,Inpp5e,Mrps18a,Wdr35,Haus7,Ift57,Prkar2b,Ppargc1a,Mrpl48,Dynlrb1,Rho,Pcm1,Nphp4,Cep164,Mapre1,Cep152,Cdk5rap2,Mrpl38,Mrps28,Mrpl37,Ift81,Ttc8,Mrps23,Prkag2,Mapk14,Tnpo1,Cep162,Mapk13,Cep135,Cngb1,Bbs9,Ift88,Arl13b,Asap1,Mrps30,Ahi1,Wdr19,Mrpl13,Mrpl33,Cdk1,Pkd1,Kifap3,Tmem216,Rab11fip3,Rab11a,Prkaa2,Mrpl3 R-MMU-5389840 Mitochondrial translation elongation 0.999319837513503 -0.00068039390194021 83 11 0.00465707027942422 2362 8688 66845,64656,232536,68565,60441,59054,66230,68537,94062,56280,52443 Mrpl33,Mrps23,Mrps35,Mrps18a,Mrpl38,Mrps30,Mrps28,Mrpl13,Mrpl3,Mrpl37,Mrpl48 R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.999329986115193 -0.000670238444420886 23 1 0.000423370025402202 2362 8688 13109 Cyp2j5 R-MMU-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.999337496475788 -0.000662723076646823 31 2 0.000846740050804403 2362 8688 83561,83456 Tdrd1,Mov10l1 R-MMU-5419276 Mitochondrial translation termination 0.999543762305439 -0.000456341802644585 85 11 0.00465707027942422 2362 8688 68565,52443,68537,56280,94062,59054,60441,66230,232536,64656,66845 Mrps18a,Mrpl48,Mrpl13,Mrpl37,Mrpl3,Mrps30,Mrpl38,Mrps28,Mrps35,Mrps23,Mrpl33 R-MMU-6799198 Complex I biogenesis 0.999572948730004 -0.00042714248235837 58 6 0.00254022015241321 2362 8688 17993,68375,76947,68194,76826,69487 Ndufs4,Ndufa8,Ndufaf6,Ndufb4,Nubpl,Ndufaf5 R-MMU-73856 RNA Polymerase II Transcription Termination 0.999600536901868 -0.000399542904769213 64 7 0.00296359017781541 2362 8688 66118,66231,228410,20643,269061,51796,18789 Sarnp,Thoc7,Cstf3,Snrpe,Cpsf7,Srrm1,Papola R-MMU-109688 Cleavage of Growing Transcript in the Termination Region 0.999600536901868 -0.000399542904769213 64 7 0.00296359017781541 2362 8688 51796,18789,228410,269061,20643,66118,66231 Srrm1,Papola,Cstf3,Cpsf7,Snrpe,Sarnp,Thoc7 R-MMU-1640170 Cell Cycle 0.999616804163101 -0.000383269275185262 596 128 0.0541913632514818 2362 8688 71978,18751,67121,16319,19687,66997,26443,259279,97122,17217,71805,66413,17120,26440,66311,26920,208628,107976,52504,229776,15078,59021,99100,217718,97114,51885,245474,319168,67967,68999,71521,381644,110379,15574,72415,77805,27223,13548,107995,12571,59126,67629,66654,51788,19088,12447,19360,22631,225182,19076,13589,15516,16905,70620,26932,103768,216080,56430,18968,319161,71782,22629,23856,19356,13555,108000,227720,77053,52696,72787,12144,15081,12572,26417,69263,18005,21664,21973,12544,17248,73738,16881,18536,66977,66336,18974,22367,214444,226747,26931,14245,223970,76499,12579,12021,103554,22194,218210,93762,66998,55948,19357,22390,19167,16906,12545,17535,19177,12534,83431,17463,12443,64009,13000,236930,22630,22190,69482,67956,68275,54563,100710,268930,56150,214552,320595,18750,244329 Ppp2r2a,Prkcb,Mastl,Incenp,Rfc1,Psmd12,Psma6,Tubgcp3,Hist2h4,Mcm4,Nup93,Psmd6,Mad1l1,Psma1,Cenpw,Cntrl,Kntc1,Babam2,Cenpo,Cdc14a,H3f3a,Rab2a,Cep152,Nek9,Hist2h3c2,Tubgcp4,Dkc1,Hist1h2ah,Pold3,Anapc10,Pds5a,Cep135,Sec13,Hus1,Sgo1,Esco1,Trp53bp1,Dyrk1a,Cdc20,Cdk6,Nek6,Spc24,Tex12,H2afz,Prkar2b,Ccne1,Rad50,Ywhaz,Rbbp8,Prim2,Mapre1,Hsp90ab1,Lmna,Ube2v2,Ppp2r5e,Tubg2,Ube2d1,Clip1,Pola1,Hist1h4n,Ankle2,Ywhah,Dido1,Rad17,E2f1,Cenpf,Nup214,Sun1,Zwint,Ndc1,Blm,H3f3b,Cdk7,Mapk3,Rfc3,Nek2,Phlda1,Top2a,Cdc45,Mdm4,Haus7,Lig1,Pcm1,Nuf2,Cenpp,Pole2,Vrk1,Cdk5rap2,Ahctf1,Ppp2r5c,Lpin1,Rmi2,Clasp2,Cdkn2b,Bard1,Psme4,Ube2e1,Nup153,Smarca5,Psmd5,Sfn,Rad21,Wee1,Psma3,Lmnb1,Cdc7,Mre11a,Psmb7,Cdk1,Ndel1,Psmd7,Ccnd1,Syne1,Csnk2a2,Ercc6l,Ywhaq,Ubc,Nup35,Kmt5a,Rpa1,Nup210,Pds5b,Pkmyt1,Mad2l1,Cep164,Phf8,Prkca,Mcph1 R-MMU-5368287 Mitochondrial translation 0.999627132324703 -0.000372937207733759 86 11 0.00465707027942422 2362 8688 56280,68537,52443,94062,66230,59054,60441,68565,232536,64656,66845 Mrpl37,Mrpl13,Mrpl48,Mrpl3,Mrps28,Mrps30,Mrpl38,Mrps18a,Mrps35,Mrps23,Mrpl33 R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.999670717635154 -0.000329336590188255 47 4 0.00169348010160881 2362 8688 108073,14816,242425,57254 Grm7,Grm1,Gabbr2,Tas2r119 R-MMU-427413 NoRC negatively regulates rRNA expression 0.999681199593952 -0.000318851233700084 92 12 0.00508044030482642 2362 8688 319168,319161,17191,51788,13433,15081,93762,15078,97122,97114,15182,20018 Hist1h2ah,Hist1h4n,Mbd2,H2afz,Dnmt1,H3f3b,Smarca5,H3f3a,Hist2h4,Hist2h3c2,Hdac2,Polr1d R-MMU-5250913 Positive epigenetic regulation of rRNA expression 0.99971899551265 -0.000281043976508665 108 15 0.00635055038103302 2362 8688 97114,97122,20018,21340,17913,18519,319161,319168,11461,110052,15078,93762,81898,15081,51788 Hist2h3c2,Hist2h4,Polr1d,Taf1b,Myo1c,Kat2b,Hist1h4n,Hist1h2ah,Actb,Dek,H3f3a,Smarca5,Sf3b1,H3f3b,H2afz R-MMU-72649 Translation initiation complex formation 0.999731445946662 -0.000268590120435055 54 5 0.00211685012701101 2362 8688 98221,68135,56347,267019,20090 Eif3m,Eif3h,Eif3c,Rps15a,Rps29 R-MMU-212165 Epigenetic regulation of gene expression 0.999739203296393 -0.000260830716981278 138 21 0.00889077053344623 2362 8688 17913,18519,214133,15182,93762,51788,15081,11461,110052,319168,20018,21340,97114,97122,81898,15078,13433,319161,17191,11569,13435 Myo1c,Kat2b,Tet2,Hdac2,Smarca5,H2afz,H3f3b,Actb,Dek,Hist1h2ah,Polr1d,Taf1b,Hist2h3c2,Hist2h4,Sf3b1,H3f3a,Dnmt1,Hist1h4n,Mbd2,Aebp2,Dnmt3a R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.999751974762931 -0.00024805600041526 88 11 0.00465707027942422 2362 8688 11837,20090,14852,56040,19704,57808,68436,225363,267019,19981,100502825 Rplp0,Rps29,Gspt1,Rplp1,Upf1,Rpl35a,Rpl34,Etf1,Rps15a,Rpl37a,Rpl37rt R-MMU-1236975 Antigen processing-Cross presentation 0.999777397843936 -0.00022262693560081 99 13 0.00550381033022862 2362 8688 26443,26440,17463,16410,103554,16419,19177,66413,66997,17969,19167,12491,66998 Psma6,Psma1,Psmd7,Itgav,Psme4,Itgb5,Psmb7,Psmd6,Psmd12,Ncf1,Psma3,Cd36,Psmd5 R-MMU-5334118 DNA methylation 0.999789235702097 -0.000210786511819264 78 9 0.00381033022861981 2362 8688 97114,97122,15078,51788,15081,13433,319161,13435,319168 Hist2h3c2,Hist2h4,H3f3a,H2afz,H3f3b,Dnmt1,Hist1h4n,Dnmt3a,Hist1h2ah R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.999790402173258 -0.000209619795436302 55 5 0.00211685012701101 2362 8688 20090,267019,56347,68135,98221 Rps29,Rps15a,Eif3c,Eif3h,Eif3m R-MMU-72165 mRNA Splicing - Minor Pathway 0.999790402173258 -0.000209619795436302 55 5 0.00211685012701101 2362 8688 22184,68705,20643,67225,81898 Zrsr2,Gtf2f2,Snrpe,Rnpc3,Sf3b1 R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.99981246341963 -0.000187554167552848 27 1 0.000423370025402202 2362 8688 230639 Cyp4a29 R-MMU-5250941 Negative epigenetic regulation of rRNA expression 0.999817278185275 -0.000182738510389721 100 13 0.00550381033022862 2362 8688 97122,97114,15182,21340,20018,319168,319161,17191,51788,15081,13433,93762,15078 Hist2h4,Hist2h3c2,Hdac2,Taf1b,Polr1d,Hist1h2ah,Hist1h4n,Mbd2,H2afz,H3f3b,Dnmt1,Smarca5,H3f3a R-MMU-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0.999839027401557 -0.000160985555922264 131 19 0.00804403048264183 2362 8688 17268,319168,18771,51788,15081,19411,16476,22658,140858,20181,13654,55982,218772,319161,15078,19401,97122,97114,381022 Meis1,Hist1h2ah,Pknox1,H2afz,H3f3b,Rarg,Jun,Pcgf2,Wdr5,Rxra,Egr2,Paxip1,Rarb,Hist1h4n,H3f3a,Rara,Hist2h4,Hist2h3c2,Kmt2d R-MMU-5619507 Activation of HOX genes during differentiation 0.999839027401557 -0.000160985555922264 131 19 0.00804403048264183 2362 8688 13654,22658,140858,20181,16476,19411,51788,15081,18771,17268,319168,381022,97114,19401,97122,15078,319161,55982,218772 Egr2,Pcgf2,Wdr5,Rxra,Jun,Rarg,H2afz,H3f3b,Pknox1,Meis1,Hist1h2ah,Kmt2d,Hist2h3c2,Rara,Hist2h4,H3f3a,Hist1h4n,Paxip1,Rarb R-MMU-1221633 Meiotic Synapsis 0.999844651171656 -0.00015536089622344 106 14 0.00592718035563082 2362 8688 319161,64009,319168,16906,15078,51788,66654,15081,19357,97114,97122,77053,16905,23856 Hist1h4n,Syne1,Hist1h2ah,Lmnb1,H3f3a,H2afz,Tex12,H3f3b,Rad21,Hist2h3c2,Hist2h4,Sun1,Lmna,Dido1 R-MMU-1221632 Meiotic synapsis 0.999844651171656 -0.00015536089622344 106 14 0.00592718035563082 2362 8688 23856,16905,77053,97122,97114,19357,15081,66654,51788,15078,16906,319168,64009,319161 Dido1,Lmna,Sun1,Hist2h4,Hist2h3c2,Rad21,H3f3b,Tex12,H2afz,H3f3a,Lmnb1,Hist1h2ah,Syne1,Hist1h4n R-MMU-211945 Phase 1 - Functionalization of compounds 0.999851950942599 -0.000148060017744072 151 23 0.00973751058425064 2362 8688 19223,232174,14148,109754,13120,14261,17161,14149,13109,20181,11864,228608,13124,11669,13070,13082,19224,18105,11622,230639,15516,18976,21391 Ptgis,Cyp26b1,Fdx1,Cyb5r3,Cyp4b1,Fmo1,Maoa,Fdxr,Cyp2j5,Rxra,Arnt2,Smox,Cyp8b1,Aldh2,Cyp11a1,Cyp26a1,Ptgs1,Nqo2,Ahr,Cyp4a29,Hsp90ab1,Pomc,Tbxas1 R-MMU-211859 Biological oxidations 0.999866718878166 -0.000133290004551953 231 40 0.0169348010160881 2362 8688 18113,14629,21391,69065,11622,15516,13521,19224,211666,18105,13070,13082,13885,228608,20181,232087,17161,14630,232174,14261,109754,18976,71670,107146,230639,23972,108645,216558,11669,68214,11864,13124,108652,23971,14149,13109,242585,19223,14148,13120 Nnmt,Gclc,Tbxas1,Chac1,Ahr,Hsp90ab1,Slc26a2,Ptgs1,Mgst2,Nqo2,Cyp11a1,Cyp26a1,Esd,Smox,Rxra,Mat2a,Maoa,Gclm,Cyp26b1,Fmo1,Cyb5r3,Pomc,Acy3,Glyat,Cyp4a29,Papss2,Mat2b,Ugp2,Aldh2,Gsto2,Arnt2,Cyp8b1,Slc35b3,Papss1,Fdxr,Cyp2j5,Slc35d1,Ptgis,Fdx1,Cyp4b1 R-MMU-573389 NoRC negatively regulates rRNA expression 0.999866762415884 -0.000133246461031306 91 11 0.00465707027942422 2362 8688 20018,97114,15182,97122,93762,15078,51788,13433,15081,319161,319168 Polr1d,Hist2h3c2,Hdac2,Hist2h4,Smarca5,H3f3a,H2afz,Dnmt1,H3f3b,Hist1h4n,Hist1h2ah R-MMU-927802 Nonsense-Mediated Decay (NMD) 0.999895084694476 -0.000104920809519645 108 14 0.00592718035563082 2362 8688 71978,20090,11837,226517,14852,57808,56040,19704,225363,71997,68436,267019,100502825,19981 Ppp2r2a,Rps29,Rplp0,Smg7,Gspt1,Rpl35a,Rplp1,Upf1,Etf1,Smg9,Rpl34,Rps15a,Rpl37rt,Rpl37a R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.999895084694476 -0.000104920809519645 108 14 0.00592718035563082 2362 8688 71978,20090,11837,226517,14852,57808,19704,56040,225363,71997,68436,267019,100502825,19981 Ppp2r2a,Rps29,Rplp0,Smg7,Gspt1,Rpl35a,Upf1,Rplp1,Etf1,Smg9,Rpl34,Rps15a,Rpl37rt,Rpl37a R-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane 0.99993621048971 -6.37915449275372e-05 89 10 0.00423370025402202 2362 8688 20090,11837,57808,56040,68436,267019,100502825,20813,19981,217337 Rps29,Rplp0,Rpl35a,Rplp1,Rpl34,Rps15a,Rpl37rt,Srp14,Rpl37a,Srp68 R-MMU-72689 Formation of a pool of free 40S subunits 0.999942814255704 -5.7187379463299e-05 95 11 0.00465707027942422 2362 8688 57808,56040,56347,20090,11837,98221,68135,100502825,19981,267019,68436 Rpl35a,Rplp1,Eif3c,Rps29,Rplp0,Eif3m,Eif3h,Rpl37rt,Rpl37a,Rps15a,Rpl34 R-MMU-73857 RNA Polymerase II Transcription 0.999954852619957 -4.51483992166252e-05 143 20 0.00846740050804403 2362 8688 13716,74427,51796,20924,72949,20643,269061,24116,18789,83602,66231,68705,13871,66118,235497,228410,68153,67655,12572,70122 Ell,Eaf1,Srrm1,Supt5,Ccnt2,Snrpe,Cpsf7,Nelfa,Papola,Gtf2a1,Thoc7,Gtf2f2,Ercc2,Sarnp,Leo1,Cstf3,Gtf2e2,Ctdp1,Cdk7,Mllt3 R-MMU-1500620 Meiosis 0.99995775193712 -4.2248955354897e-05 123 16 0.00677392040643522 2362 8688 68275,16906,319161,15078,97122,97114,16905,23856,77053,319168,64009,51788,15081,12144,66654,19357 Rpa1,Lmnb1,Hist1h4n,H3f3a,Hist2h4,Hist2h3c2,Lmna,Dido1,Sun1,Hist1h2ah,Syne1,H2afz,H3f3b,Blm,Tex12,Rad21 R-MMU-611105 Respiratory electron transport 0.999961299314782 -3.87014341090073e-05 74 7 0.00296359017781541 2362 8688 76826,69487,76947,68194,110842,17993,68375 Nubpl,Ndufaf5,Ndufaf6,Ndufb4,Etfa,Ndufs4,Ndufa8 R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.999962796297964 -3.72043941103944e-05 97 11 0.00465707027942422 2362 8688 28080,22228,69487,76947,22227,110842,17993,68375,76826,11957,68194 Atp5o,Ucp2,Ndufaf5,Ndufaf6,Ucp1,Etfa,Ndufs4,Ndufa8,Nubpl,Atp5j,Ndufb4 R-MMU-211981 Xenobiotics 0.999964500314511 -3.55003156172995e-05 41 2 0.000846740050804403 2362 8688 11622,11864 Ahr,Arnt2 R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.999968719960009 -3.12805292214309e-05 49 3 0.0012701100762066 2362 8688 66397,99683,110379 Sar1b,Sec24b,Sec13 R-MMU-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.999969556236793 -3.04442266282734e-05 75 7 0.00296359017781541 2362 8688 97122,319168,319161,97114,51788,15081,15078 Hist2h4,Hist1h2ah,Hist1h4n,Hist2h3c2,H2afz,H3f3b,H3f3a R-MMU-72172 mRNA Splicing 0.999971172269076 -2.88281464513646e-05 180 27 0.0114309906858594 2362 8688 67678,15481,66642,53379,51796,23983,71702,50783,56194,81898,18789,20643,269061,78651,67439,67225,228410,15387,68705,22184,74326,66373,19205,68592,229279,67285,80744 Lsm3,Hspa8,Ctnnbl1,Hnrnpa2b1,Srrm1,Pcbp1,Cdc5l,Lsm4,Prpf40a,Sf3b1,Papola,Snrpe,Cpsf7,Lsm6,Xab2,Rnpc3,Cstf3,Hnrnpk,Gtf2f2,Zrsr2,Hnrnpr,Lsm5,Ptbp1,Syf2,Hnrnpa3,Cwc27,Cwc22 R-MMU-72163 mRNA Splicing - Major Pathway 0.999974671862185 -2.53284585774211e-05 171 25 0.010584250635055 2362 8688 269061,20643,50783,56194,81898,18789,71702,67678,15481,66642,53379,51796,23983,229279,68592,67285,80744,66373,19205,228410,68705,15387,74326,78651,67439 Cpsf7,Snrpe,Lsm4,Prpf40a,Sf3b1,Papola,Cdc5l,Lsm3,Hspa8,Ctnnbl1,Hnrnpa2b1,Srrm1,Pcbp1,Hnrnpa3,Syf2,Cwc27,Cwc22,Lsm5,Ptbp1,Cstf3,Gtf2f2,Hnrnpk,Hnrnpr,Lsm6,Xab2 R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.999982510580837 -1.74895721042065e-05 106 12 0.00508044030482642 2362 8688 20090,11837,56347,57808,56040,217869,68436,267019,100502825,68135,19981,98221 Rps29,Rplp0,Eif3c,Rpl35a,Rplp1,Eif5,Rpl34,Rps15a,Rpl37rt,Eif3h,Rpl37a,Eif3m R-MMU-912497 Meiotic Recombination 0.999988685662719 -1.13144012886698e-05 91 9 0.00381033022861981 2362 8688 319161,68275,319168,15078,51788,15081,12144,97114,97122 Hist1h4n,Rpa1,Hist1h2ah,H3f3a,H2afz,H3f3b,Blm,Hist2h3c2,Hist2h4 R-MMU-72766 Translation 0.999989512910851 -1.04871441390878e-05 130 16 0.00677392040643522 2362 8688 267019,217869,225363,217337,98221,100502825,56347,14852,68436,19981,20813,68135,11837,20090,56040,57808 Rps15a,Eif5,Etf1,Srp68,Eif3m,Rpl37rt,Eif3c,Gspt1,Rpl34,Rpl37a,Srp14,Eif3h,Rplp0,Rps29,Rplp1,Rpl35a R-MMU-72312 rRNA processing 0.999990178596202 -9.82145202816876e-06 125 15 0.00635055038103302 2362 8688 11837,216987,73674,57316,56040,215193,57808,217109,234374,68979,68436,67276,19981,269536,100502825 Rplp0,Utp6,Wdr75,C1d,Rplp1,Utp25,Rpl35a,Utp18,Ddx49,Nol11,Rpl34,Eri1,Rpl37a,Tex10,Rpl37rt R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.999990178596202 -9.82145202816876e-06 125 15 0.00635055038103302 2362 8688 269536,100502825,19981,67276,68436,68979,234374,217109,57808,56040,215193,57316,11837,216987,73674 Tex10,Rpl37rt,Rpl37a,Eri1,Rpl34,Nol11,Ddx49,Utp18,Rpl35a,Rplp1,Utp25,C1d,Rplp0,Utp6,Wdr75 R-MMU-8868773 rRNA processing in the nucleus and cytosol 0.999990178596202 -9.82145202816876e-06 125 15 0.00635055038103302 2362 8688 234374,217109,57808,215193,56040,57316,11837,73674,216987,100502825,269536,19981,67276,68436,68979 Ddx49,Utp18,Rpl35a,Utp25,Rplp1,C1d,Rplp0,Wdr75,Utp6,Rpl37rt,Tex10,Rpl37a,Eri1,Rpl34,Nol11 R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.999992011197861 -7.9888340495586e-06 104 11 0.00465707027942422 2362 8688 68436,267019,100502825,68135,19981,98221,20090,11837,56347,57808,56040 Rpl34,Rps15a,Rpl37rt,Eif3h,Rpl37a,Eif3m,Rps29,Rplp0,Eif3c,Rpl35a,Rplp1 R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA 0.999992112802004 -7.88722909973094e-06 231 36 0.0152413209144793 2362 8688 51796,66642,71702,81898,18789,56194,56488,54563,69482,78651,68705,15387,66231,66118,66373,19205,80744,72787,227720,23983,53379,67678,15481,71805,50783,269061,20643,67225,67439,22184,74326,228410,218210,229279,68592,67285 Srrm1,Ctnnbl1,Cdc5l,Sf3b1,Papola,Prpf40a,Nxt1,Nup210,Nup35,Lsm6,Gtf2f2,Hnrnpk,Thoc7,Sarnp,Lsm5,Ptbp1,Cwc22,Ndc1,Nup214,Pcbp1,Hnrnpa2b1,Lsm3,Hspa8,Nup93,Lsm4,Cpsf7,Snrpe,Rnpc3,Xab2,Zrsr2,Hnrnpr,Cstf3,Nup153,Hnrnpa3,Syf2,Cwc27 R-MMU-72613 Eukaryotic Translation Initiation 0.999995277032305 -4.72297884786975e-06 112 12 0.00508044030482642 2362 8688 57808,56040,56347,20090,11837,98221,68135,100502825,19981,267019,217869,68436 Rpl35a,Rplp1,Eif3c,Rps29,Rplp0,Eif3m,Eif3h,Rpl37rt,Rpl37a,Rps15a,Eif5,Rpl34 R-MMU-72737 Cap-dependent Translation Initiation 0.999995277032305 -4.72297884786975e-06 112 12 0.00508044030482642 2362 8688 68436,217869,267019,19981,68135,100502825,98221,11837,20090,56347,56040,57808 Rpl34,Eif5,Rps15a,Rpl37a,Eif3h,Rpl37rt,Eif3m,Rplp0,Rps29,Eif3c,Rplp1,Rpl35a R-MMU-6805567 Keratinization 0.999998444655299 -1.55534591080936e-06 150 18 0.00762066045723963 2362 8688 110308,19143,16664,16668,18550,76560,69664,74176,75706,18772,12336,16480,13505,71529,223917,332131,227937,406219 Krt5,St14,Krt14,Krt18,Furin,Prss8,Krtap1-5,Tgm5,Krt24,Pkp1,Capns1,Jup,Dsc1,Kazn,Krt79,Krt78,Pkp4,Krt87 R-MMU-6803157 Antimicrobial peptides 0.999998624358848 -1.37564209787852e-06 60 3 0.0012701100762066 2362 8688 12652,24088,21897 Chga,Tlr2,Tlr1 R-MMU-74160 Gene Expression 0.999998952604399 -1.04739614929539e-06 1163 251 0.106265876375953 2362 8688 217109,19704,71702,83456,106931,218772,56488,12447,19360,22631,270118,225182,267019,103806,63856,69790,110052,233863,66596,239528,12393,51788,15258,14782,56187,67678,226830,269061,72949,20643,12192,67381,13197,24116,19016,228839,234374,22184,57808,18130,15574,21815,11461,319168,15378,108099,433586,234366,26399,97114,73674,20018,51796,19883,83602,81898,15078,18789,208595,68705,66118,269252,216987,78651,20620,12450,21834,66413,20813,80744,68436,70122,26440,97122,71805,13716,16009,67279,74427,19664,18129,66997,83814,50783,13433,26443,12729,13871,56040,21388,18128,74326,15182,14660,19744,67439,71978,67225,14815,67276,26416,21679,18750,13982,233833,26424,66642,68275,54563,67956,19042,11569,98221,56194,217869,225363,75627,68979,11545,66231,15511,22630,83561,11837,22190,18124,26423,69482,19981,13865,67655,22061,68106,53975,66373,24127,68428,20602,13000,213988,11835,231464,80707,15481,228829,17684,21340,108079,23983,17535,72587,18753,12534,19177,23958,140742,71997,17131,69305,17463,235497,216154,66998,228410,215193,55948,18519,19167,14000,70640,68592,68135,67285,74747,17126,103554,12021,218210,93762,70885,19401,56222,101861,14852,12177,69260,97064,110532,26931,223970,13435,100502825,227743,20924,77683,11737,18607,23988,104625,20481,69263,214133,17248,15387,21676,20181,20090,17913,12795,54170,72787,241113,18667,56417,15081,19205,12144,19411,26380,12572,26417,22629,109270,21981,69181,19356,57316,56347,26381,18718,227720,53379,94093,74370,319161,217337,17191,218333,77976,216080,226517,109019,22337,20393,68153,17127,269536,192657,229279,641340,68975 Utp18,Upf1,Cdc5l,Mov10l1,Kctd1,Rarb,Nxt1,Ccne1,Rad50,Ywhaz,Maml2,Rbbp8,Rps15a,Maml1,Taf8,Med30,Dek,Gtf3c1,Gtf3a,Ago2,Runx2,H2afz,Hipk2,Gsr,Rabggta,Lsm3,Smyd2,Cpsf7,Ccnt2,Snrpe,Zfp36l1,Med4,Gadd45a,Nelfa,Pparg,Tgif2,Ddx49,Zrsr2,Rpl35a,Ints6,Hus1,Tgif1,Actb,Hist1h2ah,Hnf4a,Prkag2,Maml3,Gatad2a,Map2k6,Hist2h3c2,Wdr75,Polr1d,Srrm1,Rora,Gtf2a1,Sf3b1,H3f3a,Papola,Mterf1b,Gtf2f2,Sarnp,Gtf3c4,Utp6,Lsm6,Plk2,Ccng1,Thrb,Psmd6,Srp14,Cwc22,Rpl34,Mllt3,Psma1,Hist2h4,Nup93,Ell,Igfbp3,Med31,Eaf1,Rbpj,Notch2,Psmd12,Nedd4l,Lsm4,Dnmt1,Psma6,Clns1a,Ercc2,Rplp1,Tbx5,Notch1,Hnrnpr,Hdac2,Gls,Rheb,Xab2,Ppp2r2a,Rnpc3,Nr3c1,Eri1,Mapk14,Tead4,Prkca,Esr1,Tnrc6a,Nr5a2,Ctnnbl1,Rpa1,Nup210,Kmt5a,Ppm1a,Aebp2,Eif3m,Prpf40a,Eif5,Etf1,Snapc1,Nol11,Parp1,Thoc7,Hspa1b,Ywhaq,Tdrd1,Rplp0,Ubc,Nr4a3,Nr5a1,Nup35,Rpl37a,Nr2f1,Ctdp1,Trp63,Nt5c3b,Ddx20,Lsm5,Xrn1,Steap3,Ncor2,Csnk2a2,Tnrc6b,Ar,Cnot6l,Wwox,Hspa8,Phf20,Cited2,Taf1b,Prkaa2,Pcbp1,Mre11a,Pan3,Prkcd,Cdk1,Psmb7,Nr2e3,Sesn1,Smg9,Smad7,Dcps,Psmd7,Leo1,Med16,Psmd5,Cstf3,Utp25,Sfn,Kat2b,Psma3,Drosha,Dcp2,Syf2,Eif3h,Cwc27,Ddit4,Smad2,Psme4,Bard1,Nup153,Smarca5,Ints10,Rara,Cited4,Ints4,Gspt1,Bnip3l,Ing2,Wwtr1,Adarb1,Ppp2r5c,Rmi2,Dnmt3a,Rpl37rt,Mapkap1,Supt5,Ehmt1,Anp32a,Pdpk1,Pin1,Cnot6,Ski,Rfc3,Tet2,Mdm4,Hnrnpk,Tead1,Rxra,Rps29,Myo1c,Plk3,Rragc,Ndc1,Prkag3,Pgr,Adar,H3f3b,Ptbp1,Blm,Rarg,Esrrb,Cdk7,Mapk3,Ywhah,Prr5,Ppp1r13b,Dyrk2,Rad17,C1d,Eif3c,Esrrg,Pip4k2a,Nup214,Hnrnpa2b1,Trim33,Rptor,Hist1h4n,Srp68,Mbd2,Ice1,Nuak1,Ube2d1,Smg7,Nabp1,Vdr,Sgk1,Gtf2e2,Smad3,Tex10,Ell2,Hnrnpa3,Nrbf2,Med27 R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.999999843663533 -1.56336479026594e-07 115 10 0.00423370025402202 2362 8688 271375,217304,16412,68713,12478,74603,17470,74482,16414,93694 Cd200r2,Cd300lb,Itgb1,Ifitm1,Cd19,Cd200r3,Cd200,Ifitm7,Itgb2,Clec2d R-MMU-372790 Signaling by GPCR 0.999999999836858 -1.63141948553308e-10 1331 264 0.111769686706181 2362 8688 14702,230972,319229,380921,12919,110651,210044,242425,14186,18708,23945,107221,16443,11820,14293,12314,18573,56696,14176,56066,23980,14183,212541,15559,240672,12778,213788,78134,16706,71111,109934,20111,20300,26443,14309,14688,16367,18783,13610,213527,22044,14714,18430,22065,258330,622434,223435,29863,14673,15461,20112,545156,26395,50501,20742,12326,11551,83961,11606,18798,26440,70839,11515,66413,20741,18575,14062,20604,84112,14677,16440,13609,17463,80901,233571,17295,18753,259040,19414,18976,109648,14708,14526,13051,320127,14184,22045,19167,242851,16439,52666,19419,11539,20315,207212,73341,20305,16867,11513,21336,320129,19084,14675,13617,16438,227288,15550,12801,80903,14164,12776,110157,239530,53972,14173,24111,18167,19353,12062,64337,18619,19262,18673,57257,13649,16591,11548,114715,26931,30044,14180,258426,14773,11554,14573,110197,13615,50780,19220,225192,20606,54611,258922,237362,381413,12767,21844,13616,241489,258408,67603,16183,18755,26932,51801,18795,18590,11852,18578,11516,19088,12313,76089,18584,69601,71704,208188,54199,14745,18610,14163,244701,66997,21333,15557,18583,216749,11535,11553,17967,20297,67653,258151,26946,218397,237880,14527,238871,171530,14172,218461,26361,16452,108058,277360,23984,14816,16590,235584,13869,19177,230857,140795,213649,19735,24001,54126,103554,30938,238377,15466,14811,231474,22355,66998,26364,14696,102098,14182,14178,243407,75547,18750,18155,17329,239766,226278,22190,19228,56183,108073,18441,19227,52250,11555,13614,269608,14678,13618,104111,12424,19417,13645,384783,57254,18607,211323,432530,11876,381489,13874,11549,269060,26417,13490,17311,74769,14709,19878,14585,240168,12775,239283,14083 Gng2,Arhgef16,Sctr,Dgkh,Crhbp,Rps6ka3,Adcy2,Gabbr2,Fgfr4,Pik3r1,Mgll,Ffar4,Itsn1,App,Fpr1,Calm2,Pde1a,Gpr132,Fgf5,Cxcl11,Pebp1,Fgfr2,Rho,Htr2b,Dusp5,Ackr3,Chrm5,Lpar4,Ksr1,Gpr39,Abr,Rps6ka1,Ccl25,Psma6,Fshr,Gnb1,Irs1,Pla2g4a,S1pr3,Pth2r,Trh,Gnrh1,Oxtr,Trpc3,Olfr1274-ps,Arhgef26,Trio,Pde7b,Gna12,Hras,Rps6ka2,Kalrn,Map2k1,Prok2,Sptbn1,Camk4,Adra2a,Nrg4,Agt,Plcb4,Psma1,P2ry12,Adcy9,Psmd6,Sptb,Pde1c,F2r,Sst,Sucnr1,Gnai1,Itpr3,S1pr1,Psmd7,Cxcr6,P2ry6,Met,Prkcd,Olfr1416,Rasa3,Pomc,Npy,Gng7,Gcg,Cx3cr1,Dgki,Fgfr3,Trhr,Psma3,Gnat3,Itpr2,Arhgef25,Rasgrp1,Adora1,Cxcl12,Arhgef17,Arhgef6,Ccl6,Lhcgr,Adcy7,Tacr1,Grk3,Prkar1a,Gna14,Ednra,Itpr1,Cxcr1,Htr1a,Cnr1,Fgf16,Fgf1,Ccr8,Raf1,Gpr20,Ngef,Fgf2,Uts2,Npy2r,Rac1,Bdkrb2,Gng13,Penk,Ptpra,Phb,Vav3,Egfr,Kl,Adra1b,Spred1,Ppp2r5c,Opn4,Fgf9,Olfr995,Grk5,Adrb1,Gdnf,Dgkg,Edn2,Rgs3,Ptgfr,Hrh4,Sstr2,Pde3a,Olfr267,Npffr1,Gpr176,Cxcr4,Tiam1,Edn3,Pde11a,Olfr463,Dusp6,Il2,Prkch,Ppp2r5e,Ramp1,Plcb1,Pdgfa,Rhob,Pde4b,Adcyap1,Prkar2b,Calm1,Rapgef2,Pde8a,Dab2ip,Arhgef3,Ghsr,Ccrl2,Lpar1,Pdyn,Fgd1,Mtnr1b,Psmd12,Tac1,Htr1f,Pde7a,Nmur2,Adm,Adra2c,Ncam1,Ccl20,4930544G11Rik,Olfr1505,Trpc7,Rasa1,1700071K01Rik,Gcgr,Pde4d,Ucn2,Fgf18,Pde8b,Avpr1b,Jak2,Camk2d,Prex1,Pde10a,Grm1,Kit,Dusp7,Erbb4,Psmb7,Ece1,P2ry14,Arhgef19,Rgs2,Tiam2,Arhgef7,Psme4,Fgd3,Gpr68,Hrh2,Grin2a,Paqr3,Vipr2,Psmd5,Adgre5,Gnb4,Arhgef18,Fgfr1,Fgf7,Qrfprl,Akap13,Prkca,Pnoc,Cxcl9,Rtp1,Prlhr,Ubc,Pth1r,Nmu,Grm7,P2ry1,Pthlh,Reep1,Adrb2,Edn1,Plekhg5,Gnai2,Ednrb,Adcy3,Cck,Rasgrf1,Egf,Irs2,Tas2r119,Pdpk1,Nrg1,Adcy1,Artn,Rxfp1,Ereg,Adra1a,Dagla,Mapk3,Drd3,Kitl,Pik3cb,Gng8,Rock2,Gfra1,Rasgrp3,Ccr7,Oxgr1,Ptk2 R-MMU-388396 GPCR downstream signaling 0.999999999851487 -1.48513213008065e-10 1065 174 0.0736663844199831 2362 8688 14309,71704,208188,14688,14163,14745,18610,244701,21333,15557,18583,13610,216749,213527,11535,22044,11553,14714,22065,18430,20297,622434,258330,14673,67653,223435,29863,258151,26946,545156,14527,238871,50501,11551,218461,26361,11606,16452,18798,277360,23984,14816,70839,11515,20604,14062,84112,16440,14677,13609,14702,230972,319229,110197,50780,13615,380921,19220,210044,225192,242425,54611,20606,18708,23945,237362,258922,16443,11820,381413,14293,12767,18573,56696,56066,13616,21844,241489,258408,16183,212541,18755,15559,51801,78134,213788,12778,18795,11852,18578,11516,109934,18584,20300,13617,14675,19228,16438,227288,56183,15550,12801,108073,12776,18441,52250,19227,11555,13614,269608,53972,239530,14678,18167,24111,13618,19353,104111,12424,12062,18619,57254,57257,18607,432530,11548,381489,11549,269060,30044,13490,74769,19878,12775,258426,14773,11554,239283,80901,233571,18753,259040,18976,140795,213649,109648,19735,24001,14526,320127,22045,54126,30938,238377,15466,242851,16439,22355,52666,102098,11539,20315,207212,73341,20305,243407,75547,16867,11513,18155,17329,239766,21336,320129 Fshr,Arhgef3,Ghsr,Gnb1,Fgd1,Lpar1,Pdyn,Mtnr1b,Tac1,Htr1f,Pde7a,S1pr3,Nmur2,Pth2r,Adm,Trh,Adra2c,Gnrh1,Trpc3,Oxtr,Ccl20,Arhgef26,Olfr1274-ps,Gna12,4930544G11Rik,Trio,Pde7b,Olfr1505,Trpc7,Kalrn,Gcgr,Pde4d,Prok2,Adra2a,Pde8b,Avpr1b,Agt,Jak2,Plcb4,Prex1,Pde10a,Grm1,P2ry12,Adcy9,Sst,F2r,Sucnr1,Itpr3,Gnai1,S1pr1,Gng2,Arhgef16,Sctr,Dgkg,Rgs3,Edn2,Dgkh,Ptgfr,Adcy2,Hrh4,Gabbr2,Pde3a,Sstr2,Pik3r1,Mgll,Npffr1,Olfr267,Itsn1,App,Gpr176,Fpr1,Cxcr4,Pde1a,Gpr132,Cxcl11,Edn3,Tiam1,Pde11a,Olfr463,Il2,Rho,Prkch,Htr2b,Ramp1,Lpar4,Chrm5,Ackr3,Plcb1,Rhob,Pde4b,Adcyap1,Abr,Pde8a,Ccl25,Ednra,Gna14,Pth1r,Itpr1,Cxcr1,Nmu,Htr1a,Cnr1,Grm7,Ccr8,P2ry1,Reep1,Pthlh,Adrb2,Edn1,Plekhg5,Ngef,Gpr20,Gnai2,Npy2r,Uts2,Ednrb,Rac1,Adcy3,Cck,Bdkrb2,Penk,Tas2r119,Vav3,Pdpk1,Adcy1,Adra1b,Rxfp1,Adra1a,Dagla,Opn4,Drd3,Pik3cb,Rock2,Ccr7,Olfr995,Grk5,Adrb1,Oxgr1,Cxcr6,P2ry6,Prkcd,Olfr1416,Pomc,P2ry14,Arhgef19,Npy,Rgs2,Tiam2,Gcg,Dgki,Trhr,Arhgef7,Fgd3,Gpr68,Hrh2,Gnat3,Itpr2,Vipr2,Arhgef25,Arhgef18,Adora1,Cxcl12,Arhgef17,Arhgef6,Ccl6,Qrfprl,Akap13,Lhcgr,Adcy7,Pnoc,Cxcl9,Rtp1,Tacr1,Grk3 R-MMU-381753 Olfactory Signaling Pathway 0.999999999890004 -1.09995933876507e-10 535 9 0.00381033022861981 2362 8688 258408,14688,258922,259040,258330,239766,258151,52250,258426 Olfr463,Gnb1,Olfr267,Olfr1416,Olfr1274-ps,Rtp1,Olfr1505,Reep1,Olfr995