TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-MMU-6807505 RNA polymerase II transcribes snRNA genes 0.900802541012144 -0.104469200761276 72 8 0.00582665695557174 1373 8688 101861,18130,218333,72949,192657,13716,75627,63856 Ints4,Ints6,Ice1,Ccnt2,Ell2,Ell,Snapc1,Taf8 R-MMU-73772 RNA Polymerase I Promoter Escape 0.900826809659898 -0.104442259983755 32 3 0.0021849963583394 1373 8688 13871,21340,20018 Ercc2,Taf1b,Polr1d R-MMU-1170546 Prolactin receptor signaling 0.900826809659898 -0.104442259983755 32 3 0.0021849963583394 1373 8688 14600,19109,19116 Ghr,Prl,Prlr R-MMU-1296065 Inwardly rectifying K+ channels 0.900826809659898 -0.104442259983755 32 3 0.0021849963583394 1373 8688 242425,56379,16522 Gabbr2,Kcnj1,Kcnj6 R-MMU-5610780 Degradation of GLI1 by the proteasome 0.90543468541157 -0.0993401352248153 57 6 0.00436999271667881 1373 8688 26443,66998,18222,19177,17463,26440 Psma6,Psmd5,Numb,Psmb7,Psmd7,Psma1 R-MMU-597592 Post-translational protein modification 0.905613463923064 -0.0991427042375268 826 118 0.0859431900946832 1373 8688 109359,78754,30060,218138,89867,231130,74762,17248,67099,72978,218476,64138,225280,107976,12021,21969,19359,26443,230801,50873,71897,320840,19177,227195,20447,22213,59021,56336,77739,23802,14537,171212,225131,233824,53869,108148,53625,109676,21838,15251,11461,23794,67952,11545,80883,22193,21802,20440,74256,109785,26440,94192,66111,54161,99683,229595,23956,235441,271970,22428,50798,17425,244682,228366,107895,11735,30940,71805,56233,74008,21812,320311,13032,18970,12314,235497,235505,16333,241230,329777,19357,56358,66568,20441,20454,67872,327799,107260,53618,17342,56494,227327,12042,54342,14584,27223,67653,231605,229603,19128,26409,20741,13982,545260,17127,16319,11890,67196,98388,20742,19326,66998,109978,12313,78928,17463,19211,27392 Abraxas2,Galnt15,Meltf,Gmds,Sec16b,Tnip2,Mdga1,Mdm4,Mettl21a,Cnih3,Gcnt4,Ctsz,Ino80c,Babam2,Bard1,Top1,Rad23b,Psma6,Pigv,Prkn,Lypd6b,Negr1,Psmb7,Ino80d,St6galnac3,Ube2g2,Rab2a,B4galt5,Adamtsl1,Amfr,Gcnt1,Galnt10,Wac,Cog7,Rab11a,Galnt2,B3gnt2,Ank2,Thy1,Hif1a,Actb,Adamts5,Tomm20,Parp1,Ntng1,Ube2e3,Tgfa,St6gal1,Cyld,Pgm3,Psma1,C1galt1,Tmed3,Copg1,Sec24b,Adamtsl4,Neu2,Usp3,Arsj,Dctn6,Gne,Foxk1,Cntn5,Large2,Mgat5,Ank3,Usp25,Nup93,Hdac7,Arsg,Tgfbr1,Rnf152,Ctsc,Polb,Calm2,Leo1,Cd109,Ins1,St8sia6,Pigk,Rad21,Copz2,Rwdd3,St3gal3,St3gal5,Nsmce4a,Usp44,Otub1,Fut8,Mitf,Gosr2,B3gnt7,Bcl10,Gnpnat1,Gfpt2,Trp53bp1,4930544G11Rik,Galnt9,Otud7b,Pros1,Map3k7,Sptb,Esr1,Arsi,Smad3,Incenp,Asgr2,Ube2t,Chst10,Sptbn1,Rab11b,Psmd5,Art4,Calm1,Pigt,Psmd7,Pten,Pign R-MMU-5696398 Nucleotide Excision Repair 0.907270766172214 -0.0973143440109657 103 12 0.00873998543335761 1373 8688 11461,225280,108679,69263,11545,71101,19359,70620,13870,13871,227195,27015 Actb,Ino80c,Cops8,Rfc3,Parp1,Uvssa,Rad23b,Ube2v2,Ercc1,Ercc2,Ino80d,Polk R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs 0.908771319137441 -0.0956617905609576 73 8 0.00582665695557174 1373 8688 74030,76954,105841,98732,216344,102442,231874,74760 Rin2,St5,Dennd3,Rab3gap2,Rab21,Dennd4a,Ccz1,Rab3il1 R-MMU-69109 Leading Strand Synthesis 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-6785807 Interleukin-4 and 13 signaling 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 16190 Il4ra R-MMU-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 56473 Fads2 R-MMU-2046106 alpha-linolenic acid (ALA) metabolism 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 56473 Fads2 R-MMU-5682910 LGI-ADAM interactions 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 54376 Cacng3 R-MMU-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 12389 Cav1 R-MMU-174411 Polymerase switching on the C-strand of the telomere 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-391903 Eicosanoid ligand-binding receptors 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 19220 Ptgfr R-MMU-69091 Polymerase switching 0.91020162565435 -0.0940891373603749 14 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-6798695 Neutrophil degranulation 0.910744955790191 -0.0934923816317872 561 78 0.0568099053168245 1373 8688 17463,80860,109905,16414,11846,241633,104112,13014,56016,71884,16480,20813,12491,24088,21858,20409,67653,26416,17380,107767,13030,21938,15516,18033,83768,15289,14319,18772,269116,72157,70536,20868,20716,13032,442827,117586,74012,18753,227753,12359,22596,16854,208795,78892,16211,11717,20430,17064,74244,19271,29875,16790,12505,16410,69660,30960,14302,15511,18792,72269,19342,19177,18805,71517,105245,12331,75612,110173,70495,64138,56444,23912,16970,104009,210992,435350,55950,16004 Psmd7,Ghdc,Rap1a,Itgb2,Arg1,Atp8b4,Acly,Cstb,Hebp2,Chit1,Jup,Srp14,Cd36,Tlr2,Timp2,Ostf1,4930544G11Rik,Mapk14,Mme,Scamp1,Ctsb,Tnfrsf1b,Hsp90ab1,Nfkb1,Dpp7,Hmgb1,Fth1,Pkp1,Nfasc,Pgm2,Qpct,Stk10,Serpina3n,Ctsc,Rab44,A1bg,Rap2b,Prkcd,Gsn,Cat,Xrcc5,Lgals3,Tmem63a,Crispld2,Kpnb1,Ampd3,Cyfip1,Cd93,Atg7,Ptprj,Iqgap1,Anpep,Cd44,Itgav,Tmbim1,Vapa,Frk,Hspa1b,Plau,Cda,Rab4b,Psmb7,Pld1,Vps35l,Txndc5,Cap1,Gns,Manba,Atp6ap2,Ctsz,Actr10,Rhof,Lrmp,Qsox1,Lpcat1,Serpinb6e,Bri3,Igf2r R-MMU-5693532 DNA Double-Strand Break Repair 0.910849883388534 -0.0933771775301914 133 16 0.0116533139111435 1373 8688 14049,19363,70620,11545,54125,12021,69263,223970,107976,14048,16647,27015,13870,27223,22596,225182 Eya2,Rad51b,Ube2v2,Parp1,Polm,Bard1,Rfc3,Rmi2,Babam2,Eya1,Kpna2,Polk,Ercc1,Trp53bp1,Xrcc5,Rbbp8 R-MMU-179409 APC-Cdc20 mediated degradation of Nek2A 0.911625246522508 -0.0925262872568156 24 2 0.00145666423889294 1373 8688 18005,56150 Nek2,Mad2l1 R-MMU-174417 Telomere C-strand (Lagging Strand) Synthesis 0.911625246522508 -0.0925262872568156 24 2 0.00145666423889294 1373 8688 18974,69263 Pole2,Rfc3 R-MMU-73863 RNA Polymerase I Transcription Termination 0.912051788697609 -0.0920585046674203 33 3 0.0021849963583394 1373 8688 20018,21340,13871 Polr1d,Taf1b,Ercc2 R-MMU-4608870 Asymmetric localization of PCP proteins 0.913924232288859 -0.0900076078034422 58 6 0.00436999271667881 1373 8688 26440,17463,19177,22418,66998,26443 Psma1,Psmd7,Psmb7,Wnt5a,Psmd5,Psma6 R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.913924232288859 -0.0900076078034422 58 6 0.00436999271667881 1373 8688 66998,26443,17463,19177,26440,15516 Psmd5,Psma6,Psmd7,Psmb7,Psma1,Hsp90ab1 R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6 0.914344635263596 -0.0895477159466074 50 5 0.00364166059723234 1373 8688 66998,26443,19177,17463,26440 Psmd5,Psma6,Psmb7,Psmd7,Psma1 R-MMU-75105 Fatty Acyl-CoA Biosynthesis 0.914344635263596 -0.0895477159466074 50 5 0.00364166059723234 1373 8688 66834,104112,264895,171281,433256 Acot13,Acly,Acsf2,Acot3,Acsl5 R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry 0.914681554490885 -0.0891793021611872 66 7 0.00509832483612527 1373 8688 26440,12447,26443,66998,12443,17463,19177 Psma1,Ccne1,Psma6,Psmd5,Ccnd1,Psmd7,Psmb7 R-MMU-69202 Cyclin E associated events during G1/S transition 0.914681554490885 -0.0891793021611872 66 7 0.00509832483612527 1373 8688 12447,26440,12443,17463,19177,66998,26443 Ccne1,Psma1,Ccnd1,Psmd7,Psmb7,Psmd5,Psma6 R-MMU-196849 Metabolism of water-soluble vitamins and cofactors 0.917080888241777 -0.0865596009738451 112 13 0.00946831755280408 1373 8688 110821,18605,65969,67375,17434,23959,66812,68214,18563,54338,59027,56738,19223 Pcca,Enpp1,Cubn,Qprt,Mocs2,Nt5e,Ppcdc,Gsto2,Pcx,Slc23a2,Nampt,Mocs1,Ptgis R-MMU-69231 Cyclin D associated events in G1 0.92210952551405 -0.0810912712506732 34 3 0.0021849963583394 1373 8688 12571,12579,12443 Cdk6,Cdkn2b,Ccnd1 R-MMU-5689901 Metalloprotease DUBs 0.92210952551405 -0.0810912712506732 34 3 0.0021849963583394 1373 8688 109359,107976,12021 Abraxas2,Babam2,Bard1 R-MMU-69236 G1 Phase 0.92210952551405 -0.0810912712506732 34 3 0.0021849963583394 1373 8688 12579,12571,12443 Cdkn2b,Cdk6,Ccnd1 R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.922637623118152 -0.080518729242497 51 5 0.00364166059723234 1373 8688 26440,19177,17463,66998,26443 Psma1,Psmb7,Psmd7,Psmd5,Psma6 R-MMU-110312 Translesion synthesis by REV1 0.924415733106196 -0.0785933809234192 15 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-156581 Methylation 0.924415733106196 -0.0785933809234192 15 1 0.000728332119446468 1373 8688 108645 Mat2b R-MMU-549132 Organic cation/anion/zwitterion transport 0.924415733106196 -0.0785933809234192 15 1 0.000728332119446468 1373 8688 12394 Runx1 R-MMU-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 0.925376981875542 -0.0775540765212715 43 4 0.00291332847778587 1373 8688 72947,20539,209176,217593 Phykpl,Slc7a5,Ido2,Slc25a21 R-MMU-5688426 Deubiquitination 0.927849962076005 -0.0748852380647707 237 30 0.021849963583394 1373 8688 17425,327799,107260,235441,109359,231130,229603,67653,30940,17248,26409,13982,67952,107976,21812,11461,225280,15251,17127,74256,18970,12021,26440,19177,227195,19211,17463,26443,50873,66998 Foxk1,Usp44,Otub1,Usp3,Abraxas2,Tnip2,Otud7b,4930544G11Rik,Usp25,Mdm4,Map3k7,Esr1,Tomm20,Babam2,Tgfbr1,Actb,Ino80c,Hif1a,Smad3,Cyld,Polb,Bard1,Psma1,Psmb7,Ino80d,Pten,Psmd7,Psma6,Prkn,Psmd5 R-MMU-5685942 HDR through Homologous Recombination (HRR) 0.92893251831788 -0.0737191818616693 60 6 0.00436999271667881 1373 8688 19363,27015,69263,12021,223970,225182 Rad51b,Polk,Rfc3,Bard1,Rmi2,Rbbp8 R-MMU-418594 G alpha (i) signalling events 0.929437087090931 -0.0731761587902837 209 26 0.0189366351056082 1373 8688 11539,242425,13609,11606,56183,12778,11551,140795,109648,13610,20604,18619,12767,84112,239283,15557,11820,17329,80901,12062,20297,70839,20315,12801,18155,225192 Adora1,Gabbr2,S1pr1,Agt,Nmu,Ackr3,Adra2a,P2ry14,Npy,S1pr3,Sst,Penk,Cxcr4,Sucnr1,Oxgr1,Htr1f,App,Cxcl9,Cxcr6,Bdkrb2,Ccl20,P2ry12,Cxcl12,Cnr1,Pnoc,Hrh4 R-MMU-2467813 Separation of Sister Chromatids 0.930189882131286 -0.0723665393408617 166 20 0.0145666423889294 1373 8688 56430,26440,16319,83431,19177,19357,17463,26443,66998,226747,66336,71521,26932,76499,108000,52696,17120,100710,67629,56150 Clip1,Psma1,Incenp,Ndel1,Psmb7,Rad21,Psmd7,Psma6,Psmd5,Ahctf1,Cenpp,Pds5a,Ppp2r5e,Clasp2,Cenpf,Zwint,Mad1l1,Pds5b,Spc24,Mad2l1 R-MMU-69613 p53-Independent G1/S DNA damage checkpoint 0.930211096351516 -0.0723437332678953 52 5 0.00364166059723234 1373 8688 26443,66998,17463,19177,26440 Psma6,Psmd5,Psmd7,Psmb7,Psma1 R-MMU-69610 p53-Independent DNA Damage Response 0.930211096351516 -0.0723437332678953 52 5 0.00364166059723234 1373 8688 26440,26443,66998,17463,19177 Psma1,Psma6,Psmd5,Psmd7,Psmb7 R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.930211096351516 -0.0723437332678953 52 5 0.00364166059723234 1373 8688 26440,66998,26443,19177,17463 Psma1,Psmd5,Psma6,Psmb7,Psmd7 R-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex 0.933131540931875 -0.0692091010072885 26 2 0.00145666423889294 1373 8688 230484,69263 Usp1,Rfc3 R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.933131540931875 -0.0692091010072885 26 2 0.00145666423889294 1373 8688 16522,242425 Kcnj6,Gabbr2 R-MMU-1296059 G protein gated Potassium channels 0.933131540931875 -0.0692091010072885 26 2 0.00145666423889294 1373 8688 16522,242425 Kcnj6,Gabbr2 R-MMU-1296041 Activation of G protein gated Potassium channels 0.933131540931875 -0.0692091010072885 26 2 0.00145666423889294 1373 8688 242425,16522 Gabbr2,Kcnj6 R-MMU-157579 Telomere Maintenance 0.933131540931875 -0.0692091010072885 26 2 0.00145666423889294 1373 8688 18974,69263 Pole2,Rfc3 R-MMU-180786 Extension of Telomeres 0.933131540931875 -0.0692091010072885 26 2 0.00145666423889294 1373 8688 69263,18974 Rfc3,Pole2 R-MMU-1538133 G0 and Early G1 0.933131540931875 -0.0692091010072885 26 2 0.00145666423889294 1373 8688 13548,12447 Dyrk1a,Ccne1 R-MMU-156580 Phase II conjugation 0.935412627896239 -0.0667675337854957 77 8 0.00582665695557174 1373 8688 211666,13885,23972,23971,108645,107146,216558,68214 Mgst2,Esd,Papss2,Papss1,Mat2b,Glyat,Ugp2,Gsto2 R-MMU-5358346 Hedgehog ligand biogenesis 0.93553292616006 -0.0666389375644823 61 6 0.00436999271667881 1373 8688 226861,26440,66998,26443,19177,17463 Hhat,Psma1,Psmd5,Psma6,Psmb7,Psmd7 R-MMU-5656121 Translesion synthesis by POLI 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-69205 G1/S-Specific Transcription 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 12447 Ccne1 R-MMU-429958 mRNA decay by 3' to 5' exoribonuclease 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 69305 Dcps R-MMU-193048 Androgen biosynthesis 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 94224 Srd5a2 R-MMU-416993 Trafficking of GluR2-containing AMPA receptors 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 18750 Prkca R-MMU-166663 Initial triggering of complement 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 239447 Colec10 R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 69807 Trim32 R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 20910 Stxbp1 R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle 0.9363812811937 -0.0657325337470548 16 1 0.000728332119446468 1373 8688 20910 Stxbp1 R-MMU-5656169 Termination of translesion DNA synthesis 0.94192690643627 -0.0598276014330435 27 2 0.00145666423889294 1373 8688 27015,69263 Polk,Rfc3 R-MMU-1266695 Interleukin-7 signaling 0.94192690643627 -0.0598276014330435 27 2 0.00145666423889294 1373 8688 18708,18710 Pik3r1,Pik3r3 R-MMU-2299718 Condensation of Prophase Chromosomes 0.94192690643627 -0.0598276014330435 27 2 0.00145666423889294 1373 8688 320595,244329 Phf8,Mcph1 R-MMU-983231 Factors involved in megakaryocyte development and platelet production 0.94239099984622 -0.059335016378487 117 13 0.00946831755280408 1373 8688 16593,17135,17133,105445,75974,12345,19363,15977,19084,19088,15078,330662,68732 Klc1,Mafk,Maff,Dock9,Dock11,Capzb,Rad51b,Ifnb1,Prkar1a,Prkar2b,H3f3a,Dock1,Carmil1 R-MMU-5689603 UCH proteinases 0.942427481131997 -0.0592963057162677 94 10 0.00728332119446468 1373 8688 17425,11461,225280,12021,26440,227195,17463,19177,26443,66998 Foxk1,Actb,Ino80c,Bard1,Psma1,Ino80d,Psmd7,Psmb7,Psma6,Psmd5 R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1 0.943401417703044 -0.0582634053738894 54 5 0.00364166059723234 1373 8688 26440,19177,17463,66998,26443 Psma1,Psmb7,Psmd7,Psmd5,Psma6 R-MMU-4641257 Degradation of AXIN 0.943401417703044 -0.0582634053738894 54 5 0.00364166059723234 1373 8688 17463,19177,66998,26443,26440 Psmd7,Psmb7,Psmd5,Psma6,Psma1 R-MMU-6809371 Formation of the cornified envelope 0.943401417703044 -0.0582634053738894 54 5 0.00364166059723234 1373 8688 12336,76560,16480,71529,18772 Capns1,Prss8,Jup,Kazn,Pkp1 R-MMU-674695 RNA Polymerase II Pre-transcription Events 0.945977316206722 -0.0555366888575795 79 8 0.00582665695557174 1373 8688 235497,13871,13716,24116,72949,70122,20924,67655 Leo1,Ercc2,Ell,Nelfa,Ccnt2,Mllt3,Supt5,Ctdp1 R-MMU-8856688 Golgi-to-ER retrograde transport 0.945977316206722 -0.0555366888575795 79 8 0.00582665695557174 1373 8688 108148,56358,54161,18783,66111,98732,16593,22428 Galnt2,Copz2,Copg1,Pla2g4a,Tmed3,Rab3gap2,Klc1,Dctn6 R-MMU-196071 Metabolism of steroid hormones 0.946288938392256 -0.0552073248607387 37 3 0.0021849963583394 1373 8688 76205,94224,13070 Stard3nl,Srd5a2,Cyp11a1 R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.946453755939822 -0.0550331674874457 17 1 0.000728332119446468 1373 8688 21943 Tnfsf11 R-MMU-1660514 Synthesis of PIPs at the Golgi membrane 0.946453755939822 -0.0550331674874457 17 1 0.000728332119446468 1373 8688 234729 Vac14 R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.946453755939822 -0.0550331674874457 17 1 0.000728332119446468 1373 8688 14675 Gna14 R-MMU-5423646 Aflatoxin activation and detoxification 0.946453755939822 -0.0550331674874457 17 1 0.000728332119446468 1373 8688 211666 Mgst2 R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.949114088539862 -0.0522262678510665 55 5 0.00364166059723234 1373 8688 26443,66998,17463,19177,26440 Psma6,Psmd5,Psmd7,Psmb7,Psma1 R-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.949614736921428 -0.0516989167238766 28 2 0.00145666423889294 1373 8688 19744,74370 Rheb,Rptor R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.949614736921428 -0.0516989167238766 28 2 0.00145666423889294 1373 8688 13871,20924 Ercc2,Supt5 R-MMU-2142753 Arachidonic acid metabolism 0.951065346553954 -0.0501725052811622 72 7 0.00509832483612527 1373 8688 19224,13109,18979,18783,11690,11686,19223 Ptgs1,Cyp2j5,Pon1,Pla2g4a,Alox5ap,Alox12b,Ptgis R-MMU-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.951065346553954 -0.0501725052811622 72 7 0.00509832483612527 1373 8688 26440,18005,56150,66998,26443,17463,19177 Psma1,Nek2,Mad2l1,Psmd5,Psma6,Psmd7,Psmb7 R-MMU-68882 Mitotic Anaphase 0.952224066283388 -0.0489549081414171 172 20 0.0145666423889294 1373 8688 108000,17120,52696,100710,67629,56150,56430,16319,26440,17463,83431,19357,19177,66998,26443,71521,66336,226747,76499,26932 Cenpf,Mad1l1,Zwint,Pds5b,Spc24,Mad2l1,Clip1,Incenp,Psma1,Psmd7,Ndel1,Rad21,Psmb7,Psmd5,Psma6,Pds5a,Cenpp,Ahctf1,Clasp2,Ppp2r5e R-MMU-5334727 Mus musculus biological processes 0.953524631176065 -0.0475900218934943 238 29 0.0211216314639476 1373 8688 14815,51788,19357,19883,93762,12702,76199,64009,15078,67279,15182,13654,68975,19247,20181,68910,59027,16906,20602,77053,79362,18143,12953,16600,20018,20787,19017,11865,69790 Nr3c1,H2afz,Rad21,Rora,Smarca5,Socs3,Med13l,Syne1,H3f3a,Med31,Hdac2,Egr2,Med27,Ptpn11,Rxra,Zfp467,Nampt,Lmnb1,Ncor2,Sun1,Bhlhe41,Npas2,Cry2,Klf4,Polr1d,Srebf1,Ppargc1a,Arntl,Med30 R-MMU-437239 Recycling pathway of L1 0.954932477316355 -0.0461146453818596 18 1 0.000728332119446468 1373 8688 18222 Numb R-MMU-110320 Translesion Synthesis by POLH 0.954932477316355 -0.0461146453818596 18 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-189445 Metabolism of porphyrins 0.954932477316355 -0.0461146453818596 18 1 0.000728332119446468 1373 8688 14151 Fech R-MMU-2555396 Mitotic Metaphase and Anaphase 0.955243883125069 -0.0457885961039791 173 20 0.0145666423889294 1373 8688 226747,66336,71521,26932,76499,56430,26440,16319,83431,17463,19177,19357,66998,26443,100710,67629,56150,108000,52696,17120 Ahctf1,Cenpp,Pds5a,Ppp2r5e,Clasp2,Clip1,Psma1,Incenp,Ndel1,Psmd7,Psmb7,Rad21,Psmd5,Psma6,Pds5b,Spc24,Mad2l1,Cenpf,Zwint,Mad1l1 R-MMU-5693607 Processing of DNA double-strand break ends 0.955551076728699 -0.0454670612321269 73 7 0.00509832483612527 1373 8688 69263,12021,70620,107976,223970,225182,27223 Rfc3,Bard1,Ube2v2,Babam2,Rmi2,Rbbp8,Trp53bp1 R-MMU-3371556 Cellular response to heat stress 0.955551076728699 -0.0454670612321269 73 7 0.00509832483612527 1373 8688 29810,71805,68196,15511,74370,108058,15516 Bag3,Nup93,Hsbp1,Hspa1b,Rptor,Camk2d,Hsp90ab1 R-MMU-5620924 Intraflagellar transport 0.958311150073445 -0.0425827624361583 39 3 0.0021849963583394 1373 8688 73916,238799,213081 Ift57,Tnpo1,Wdr19 R-MMU-4641258 Degradation of DVL 0.95899702391674 -0.0418673074228677 57 5 0.00364166059723234 1373 8688 17463,19177,66998,26443,26440 Psmd7,Psmb7,Psmd5,Psma6,Psma1 R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.959663558867164 -0.0411725154589128 74 7 0.00509832483612527 1373 8688 18005,26440,17463,19177,56150,66998,26443 Nek2,Psma1,Psmd7,Psmb7,Mad2l1,Psmd5,Psma6 R-MMU-211935 Fatty acids 0.962069467938525 -0.038668618929282 19 1 0.000728332119446468 1373 8688 13109 Cyp2j5 R-MMU-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.962069467938525 -0.038668618929282 19 1 0.000728332119446468 1373 8688 229776 Cdc14a R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.962174766809337 -0.0385591745365013 30 2 0.00145666423889294 1373 8688 20018,75627 Polr1d,Snapc1 R-MMU-72086 mRNA Capping 0.962174766809337 -0.0385591745365013 30 2 0.00145666423889294 1373 8688 20924,13871 Supt5,Ercc2 R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation 0.962283119623508 -0.0384465684721657 91 9 0.00655498907501821 1373 8688 15258,225182,223970,77976,12021,26416,69263,17248,69181 Hipk2,Rbbp8,Rmi2,Nuak1,Bard1,Mapk14,Rfc3,Mdm4,Dyrk2 R-MMU-2990846 SUMOylation 0.962297555481441 -0.0384315669104023 99 10 0.00728332119446468 1373 8688 67872,21969,17342,11545,27223,16319,66568,19357,56233,71805 Nsmce4a,Top1,Mitf,Parp1,Trp53bp1,Incenp,Rwdd3,Rad21,Hdac7,Nup93 R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex 0.963249174072878 -0.0374431529142055 58 5 0.00364166059723234 1373 8688 26440,26443,66998,19177,17463 Psma1,Psma6,Psmd5,Psmb7,Psmd7 R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.963249174072878 -0.0374431529142055 58 5 0.00364166059723234 1373 8688 26440,26443,66998,17463,19177 Psma1,Psma6,Psmd5,Psmd7,Psmb7 R-MMU-5676590 NIK-->noncanonical NF-kB signaling 0.963249174072878 -0.0374431529142055 58 5 0.00364166059723234 1373 8688 26443,66998,17463,19177,26440 Psma6,Psmd5,Psmd7,Psmb7,Psma1 R-MMU-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.963429210544921 -0.0372562649789846 75 7 0.00509832483612527 1373 8688 18005,26440,17463,19177,56150,66998,26443 Nek2,Psma1,Psmd7,Psmb7,Mad2l1,Psmd5,Psma6 R-MMU-453276 Regulation of mitotic cell cycle 0.965986367121417 -0.0346055575799522 84 8 0.00582665695557174 1373 8688 229776,56150,18005,26440,17463,19177,66998,26443 Cdc14a,Mad2l1,Nek2,Psma1,Psmd7,Psmb7,Psmd5,Psma6 R-MMU-174143 APC/C-mediated degradation of cell cycle proteins 0.965986367121417 -0.0346055575799522 84 8 0.00582665695557174 1373 8688 17463,19177,66998,26443,18005,26440,56150,229776 Psmd7,Psmb7,Psmd5,Psma6,Nek2,Psma1,Mad2l1,Cdc14a R-MMU-390522 Striated Muscle Contraction 0.967267878015036 -0.033279802227759 31 2 0.00145666423889294 1373 8688 59069,21956 Tpm3,Tnnt2 R-MMU-68962 Activation of the pre-replicative complex 0.967267878015036 -0.033279802227759 31 2 0.00145666423889294 1373 8688 12545,18974 Cdc7,Pole2 R-MMU-420092 Glucagon-type ligand receptors 0.967267878015036 -0.033279802227759 31 2 0.00145666423889294 1373 8688 319229,14526 Sctr,Gcg R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.967772960370655 -0.032757764287194 41 3 0.0021849963583394 1373 8688 93762,66311,66336 Smarca5,Cenpw,Cenpp R-MMU-774815 Nucleosome assembly 0.967772960370655 -0.032757764287194 41 3 0.0021849963583394 1373 8688 66336,66311,93762 Cenpp,Cenpw,Smarca5 R-MMU-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 0.968076922145077 -0.0324437298368323 20 1 0.000728332119446468 1373 8688 56150 Mad2l1 R-MMU-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.968076922145077 -0.0324437298368323 20 1 0.000728332119446468 1373 8688 56150 Mad2l1 R-MMU-69186 Lagging Strand Synthesis 0.968076922145077 -0.0324437298368323 20 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-171052 LDL-mediated lipid transport 0.968076922145077 -0.0324437298368323 20 1 0.000728332119446468 1373 8688 238055 Apob R-MMU-983189 Kinesins 0.968076922145077 -0.0324437298368323 20 1 0.000728332119446468 1373 8688 16593 Klc1 R-MMU-901032 ER Quality Control Compartment (ERQC) 0.968076922145077 -0.0324437298368323 20 1 0.000728332119446468 1373 8688 23802 Amfr R-MMU-5693538 Homology Directed Repair 0.968407943600803 -0.0321018511422911 109 11 0.00801165331391114 1373 8688 225182,107976,223970,11545,12021,69263,13870,27223,70620,19363,27015 Rbbp8,Babam2,Rmi2,Parp1,Bard1,Rfc3,Ercc1,Trp53bp1,Ube2v2,Rad51b,Polk R-MMU-3108232 SUMO E3 ligases SUMOylate target proteins 0.968548646128507 -0.0319565690758805 93 9 0.00655498907501821 1373 8688 56233,19357,71805,16319,27223,21969,11545,17342,67872 Hdac7,Rad21,Nup93,Incenp,Trp53bp1,Top1,Parp1,Mitf,Nsmce4a R-MMU-2559580 Oxidative Stress Induced Senescence 0.972889877002367 -0.0274843820272713 78 7 0.00509832483612527 1373 8688 26399,26416,12571,15078,12579,17248,16476 Map2k6,Mapk14,Cdk6,H3f3a,Cdkn2b,Mdm4,Jun R-MMU-3214841 PKMTs methylate histone lysines 0.974379058114561 -0.0259548743402199 70 6 0.00436999271667881 1373 8688 69726,18033,11569,14013,226830,225888 Smyd3,Nfkb1,Aebp2,Mecom,Smyd2,Kmt5b R-MMU-2980766 Nuclear Envelope Breakdown 0.97517981768121 -0.0251333965981307 43 3 0.0021849963583394 1373 8688 18750,71805,14245 Prkca,Nup93,Lpin1 R-MMU-212300 PRC2 methylates histones and DNA 0.97517981768121 -0.0251333965981307 43 3 0.0021849963583394 1373 8688 11569,15078,13435 Aebp2,H3f3a,Dnmt3a R-MMU-73728 RNA Polymerase I Promoter Opening 0.97554537897906 -0.024758601314043 33 2 0.00145666423889294 1373 8688 17191,15078 Mbd2,H3f3a R-MMU-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.975798966193812 -0.0244986910457121 104 10 0.00728332119446468 1373 8688 225182,223970,107976,12021,69263,27223,13870,70620,27015,19363 Rbbp8,Rmi2,Babam2,Bard1,Rfc3,Trp53bp1,Ercc1,Ube2v2,Polk,Rad51b R-MMU-6782135 Dual incision in TC-NER 0.976505225490494 -0.0237751774349762 62 5 0.00364166059723234 1373 8688 27015,69263,71101,13871,13870 Polk,Rfc3,Uvssa,Ercc2,Ercc1 R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.976505225490494 -0.0237751774349762 62 5 0.00364166059723234 1373 8688 19177,17463,26443,66998,26440 Psmb7,Psmd7,Psma6,Psmd5,Psma1 R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.976761263991664 -0.0235130130001528 53 4 0.00291332847778587 1373 8688 66111,16593,56358,54161 Tmed3,Klc1,Copz2,Copg1 R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.976982169505392 -0.023286877356259 71 6 0.00436999271667881 1373 8688 19177,17463,66998,56150,26443,26440 Psmb7,Psmd7,Psmd5,Mad2l1,Psma6,Psma1 R-MMU-975298 Ligand-gated ion channel transport 0.977389606906098 -0.0228699276115621 22 1 0.000728332119446468 1373 8688 14658 Glrb R-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs 0.977389606906098 -0.0228699276115621 22 1 0.000728332119446468 1373 8688 433256 Acsl5 R-MMU-1614635 Sulfur amino acid metabolism 0.977389606906098 -0.0228699276115621 22 1 0.000728332119446468 1373 8688 66071 Ethe1 R-MMU-73854 RNA Polymerase I Promoter Clearance 0.977888643746428 -0.0223594766299699 80 7 0.00509832483612527 1373 8688 21340,13871,15078,20018,17191,234366,15182 Taf1b,Ercc2,H3f3a,Polr1d,Mbd2,Gatad2a,Hdac2 R-MMU-4615885 SUMOylation of DNA replication proteins 0.978246434221795 -0.02199366295648 44 3 0.0021849963583394 1373 8688 21969,71805,16319 Top1,Nup93,Incenp R-MMU-73893 DNA Damage Bypass 0.978246434221795 -0.02199366295648 44 3 0.0021849963583394 1373 8688 69263,27015,230484 Rfc3,Polk,Usp1 R-MMU-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.978885119803514 -0.0213409877665284 34 2 0.00145666423889294 1373 8688 19359,23802 Rad23b,Amfr R-MMU-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 0.978885119803514 -0.0213409877665284 34 2 0.00145666423889294 1373 8688 69263,27015 Rfc3,Polk R-MMU-5250924 B-WICH complex positively regulates rRNA expression 0.979038291205668 -0.0211845246468729 63 5 0.00364166059723234 1373 8688 93762,11461,21340,15078,20018 Smarca5,Actb,Taf1b,H3f3a,Polr1d R-MMU-73864 RNA Polymerase I Transcription 0.980055375283228 -0.02014620352284 81 7 0.00509832483612527 1373 8688 15182,13871,21340,20018,17191,234366,15078 Hdac2,Ercc2,Taf1b,Polr1d,Mbd2,Gatad2a,H3f3a R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation 0.980971890527593 -0.0192114737237438 23 1 0.000728332119446468 1373 8688 54368 Gp9 R-MMU-933541 TRAF6 mediated IRF7 activation 0.980971890527593 -0.0192114737237438 23 1 0.000728332119446468 1373 8688 15977 Ifnb1 R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.980971890527593 -0.0192114737237438 23 1 0.000728332119446468 1373 8688 13109 Cyp2j5 R-MMU-69620 Cell Cycle Checkpoints 0.981349211890716 -0.0188269073372254 178 19 0.0138383102694829 1373 8688 17120,17248,27223,56150,22630,12447,225182,66998,26443,17463,19177,26440,70620,12021,69263,22631,12545,223970,107976 Mad1l1,Mdm4,Trp53bp1,Mad2l1,Ywhaq,Ccne1,Rbbp8,Psmd5,Psma6,Psmd7,Psmb7,Psma1,Ube2v2,Bard1,Rfc3,Ywhaz,Cdc7,Rmi2,Babam2 R-MMU-69481 G2/M Checkpoints 0.981423826337404 -0.0187508777145732 147 15 0.010924981791697 1373 8688 70620,27223,26440,19177,17463,66998,26443,223970,107976,22631,12545,225182,22630,69263,12021 Ube2v2,Trp53bp1,Psma1,Psmb7,Psmd7,Psmd5,Psma6,Rmi2,Babam2,Ywhaz,Cdc7,Rbbp8,Ywhaq,Rfc3,Bard1 R-MMU-1236975 Antigen processing-Cross presentation 0.982104422541622 -0.0180576396805772 99 9 0.00655498907501821 1373 8688 17969,16410,16419,12491,19177,17463,66998,26443,26440 Ncf1,Itgav,Itgb5,Cd36,Psmb7,Psmd7,Psmd5,Psma6,Psma1 R-MMU-211897 Cytochrome P450 - arranged by substrate type 0.982104422541622 -0.0180576396805772 99 9 0.00655498907501821 1373 8688 232174,11864,13124,13082,13070,20181,13109,19223,11622 Cyp26b1,Arnt2,Cyp8b1,Cyp26a1,Cyp11a1,Rxra,Cyp2j5,Ptgis,Ahr R-MMU-5689880 Ub-specific processing proteases 0.982306890305971 -0.0178515038639674 171 18 0.0131099781500364 1373 8688 67952,21812,15251,17127,18970,74256,26440,17463,19211,19177,26443,66998,327799,107260,235441,30940,17248,26409 Tomm20,Tgfbr1,Hif1a,Smad3,Polb,Cyld,Psma1,Psmd7,Pten,Psmb7,Psma6,Psmd5,Usp44,Otub1,Usp3,Usp25,Mdm4,Map3k7 R-MMU-73894 DNA Repair 0.982433434006468 -0.0177226891813277 269 31 0.0225782957028405 1373 8688 67196,19359,70620,14049,19363,227195,11461,225280,223970,107976,14048,11545,12021,54125,108679,18970,69263,13870,27223,13871,26430,330554,16647,67030,27015,225182,230484,22596,71101,14088,26383 Ube2t,Rad23b,Ube2v2,Eya2,Rad51b,Ino80d,Actb,Ino80c,Rmi2,Babam2,Eya1,Parp1,Bard1,Polm,Cops8,Polb,Rfc3,Ercc1,Trp53bp1,Ercc2,Parg,Fan1,Kpna2,Fancl,Polk,Rbbp8,Usp1,Xrcc5,Uvssa,Fancc,Fto R-MMU-69242 S Phase 0.982749489717206 -0.017401033919981 124 12 0.00873998543335761 1373 8688 26440,18974,26443,66998,17463,19177,19357,12443,12447,71521,100710,69263 Psma1,Pole2,Psma6,Psmd5,Psmd7,Psmb7,Rad21,Ccnd1,Ccne1,Pds5a,Pds5b,Rfc3 R-MMU-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.983392398400019 -0.0167470539507703 74 6 0.00436999271667881 1373 8688 13870,13871,71101,108679,27015,69263 Ercc1,Ercc2,Uvssa,Cops8,Polk,Rfc3 R-MMU-69002 DNA Replication Pre-Initiation 0.983811010289324 -0.01632146309039 83 7 0.00509832483612527 1373 8688 18974,12545,26440,19177,17463,66998,26443 Pole2,Cdc7,Psma1,Psmb7,Psmd7,Psmd5,Psma6 R-MMU-68874 M/G1 Transition 0.983811010289324 -0.01632146309039 83 7 0.00509832483612527 1373 8688 18974,12545,26440,26443,66998,17463,19177 Pole2,Cdc7,Psma1,Psma6,Psmd5,Psmd7,Psmb7 R-MMU-69190 DNA strand elongation 0.983986962005748 -0.0161426320118239 24 1 0.000728332119446468 1373 8688 69263 Rfc3 R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.983986962005748 -0.0161426320118239 24 1 0.000728332119446468 1373 8688 11551 Adra2a R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 0.983986962005748 -0.0161426320118239 24 1 0.000728332119446468 1373 8688 65969 Cubn R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin 0.985187633223695 -0.014923165368644 66 5 0.00364166059723234 1373 8688 26443,66998,19177,17463,26440 Psma6,Psmd5,Psmb7,Psmd7,Psma1 R-MMU-176187 Activation of ATR in response to replication stress 0.986461078341106 -0.0136314085896421 37 2 0.00145666423889294 1373 8688 69263,12545 Rfc3,Cdc7 R-MMU-901042 Calnexin/calreticulin cycle 0.986524577566697 -0.0135670399254069 25 1 0.000728332119446468 1373 8688 23802 Amfr R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase 0.986693056846777 -0.0133962738856644 76 6 0.00436999271667881 1373 8688 26440,26443,66998,56150,19177,17463 Psma1,Psma6,Psmd5,Mad2l1,Psmb7,Psmd7 R-MMU-68867 Assembly of the pre-replicative complex 0.986827598266324 -0.013259927281531 67 5 0.00364166059723234 1373 8688 66998,26443,17463,19177,26440 Psmd5,Psma6,Psmd7,Psmb7,Psma1 R-MMU-73886 Chromosome Maintenance 0.986827598266324 -0.013259927281531 67 5 0.00364166059723234 1373 8688 18974,66336,66311,69263,93762 Pole2,Cenpp,Cenpw,Rfc3,Smarca5 R-MMU-1592389 Activation of Matrix Metalloproteinases 0.987265720713233 -0.0128160552012301 48 3 0.0021849963583394 1373 8688 21858,17386,17393 Timp2,Mmp13,Mmp7 R-MMU-427359 SIRT1 negatively regulates rRNA Expression 0.988339173228812 -0.011729347404028 38 2 0.00145666423889294 1373 8688 21340,15078 Taf1b,H3f3a R-MMU-74158 RNA Polymerase III Transcription 0.988339173228812 -0.011729347404028 38 2 0.00145666423889294 1373 8688 20018,75627 Polr1d,Snapc1 R-MMU-76046 RNA Polymerase III Transcription Initiation 0.988339173228812 -0.011729347404028 38 2 0.00145666423889294 1373 8688 75627,20018 Snapc1,Polr1d R-MMU-113510 E2F mediated regulation of DNA replication 0.988660299034916 -0.0114044855986168 26 1 0.000728332119446468 1373 8688 12447 Ccne1 R-MMU-392499 Metabolism of proteins 0.989099193947583 -0.0109606551718852 1115 151 0.109978150036417 1373 8688 69048,78928,109978,27392,19211,13982,545260,17127,14584,27223,54342,229603,217337,19128,56494,53618,17380,17342,12042,235497,12314,66568,19357,13032,68436,107895,235441,18548,17425,22428,50798,228366,244682,217869,94192,109785,229595,54161,99683,70546,67952,23794,16324,20440,22193,21802,140740,16323,233824,109676,22213,77739,23802,56336,16006,107221,50873,26443,23850,227195,19177,226641,225280,107976,72061,11551,17248,64138,218476,78754,231130,74762,67196,11890,16319,19326,20742,98388,12313,66998,17463,19981,20741,20813,11606,231605,67653,16008,12876,26409,20441,20454,107260,67872,327799,267019,68135,227327,235505,20698,329777,241230,16333,56358,21812,320311,18970,30940,11735,66212,16000,71805,74008,56233,271970,30937,26440,16009,66111,23956,11461,15251,18491,80883,11545,74256,171212,225131,21838,53869,108148,53625,20447,59021,56040,76687,14537,14526,19359,230801,320840,71897,70495,12021,21969,67099,72978,109359,218138,30060,89867 Slc30a5,Pigt,Art4,Pign,Pten,Esr1,Arsi,Smad3,Gfpt2,Trp53bp1,Gnpnat1,Otud7b,Srp68,Pros1,Gosr2,Fut8,Mme,Mitf,Bcl10,Leo1,Calm2,Rwdd3,Rad21,Ctsc,Rpl34,Mgat5,Usp3,Pcsk1,Foxk1,Dctn6,Gne,Large2,Cntn5,Eif5,C1galt1,Pgm3,Adamtsl4,Copg1,Sec24b,Zdhhc2,Tomm20,Adamts5,Inhbb,St6gal1,Ube2e3,Tgfa,Sec63,Inhba,Cog7,Ank2,Ube2g2,Adamtsl1,Amfr,B4galt5,Igfbp1,Ffar4,Prkn,Psma6,Pappa2,Ino80d,Psmb7,Atf6,Ino80c,Babam2,Aopep,Adra2a,Mdm4,Ctsz,Gcnt4,Galnt15,Tnip2,Mdga1,Ube2t,Asgr2,Incenp,Rab11b,Sptbn1,Chst10,Calm1,Psmd5,Psmd7,Rpl37a,Sptb,Srp14,Agt,Galnt9,4930544G11Rik,Igfbp2,Cpe,Map3k7,St3gal3,St3gal5,Otub1,Nsmce4a,Usp44,Rps15a,Eif3h,B3gnt7,Cd109,Sphk1,Pigk,St8sia6,Ins1,Copz2,Tgfbr1,Rnf152,Polb,Usp25,Ank3,Sec61b,Igf1,Nup93,Arsg,Hdac7,Arsj,Lmcd1,Psma1,Igfbp3,Tmed3,Neu2,Actb,Hif1a,Pappa,Ntng1,Parp1,Cyld,Galnt10,Wac,Thy1,Rab11a,Galnt2,B3gnt2,St6galnac3,Rab2a,Rplp1,Spcs3,Gcnt1,Gcg,Rad23b,Pigv,Negr1,Lypd6b,Atp6ap2,Bard1,Top1,Mettl21a,Cnih3,Abraxas2,Gmds,Meltf,Sec16b R-MMU-68875 Mitotic Prophase 0.989369801000418 -0.0106871031928405 78 6 0.00436999271667881 1373 8688 59021,244329,18750,14245,320595,71805 Rab2a,Mcph1,Prkca,Lpin1,Phf8,Nup93 R-MMU-69052 Switching of origins to a post-replicative state 0.99077789862668 -0.00926488820971321 70 5 0.00364166059723234 1373 8688 26443,66998,17463,19177,26440 Psma6,Psmd5,Psmd7,Psmb7,Psma1 R-MMU-68949 Orc1 removal from chromatin 0.99077789862668 -0.00926488820971321 70 5 0.00364166059723234 1373 8688 17463,19177,66998,26443,26440 Psmd7,Psmb7,Psmd5,Psma6,Psma1 R-MMU-165159 mTOR signalling 0.991364097106417 -0.00867340838829843 40 2 0.00145666423889294 1373 8688 74370,19744 Rptor,Rheb R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.991436221024005 -0.00860065883610197 61 4 0.00291332847778587 1373 8688 27015,69263,71101,13871 Polk,Rfc3,Uvssa,Ercc2 R-MMU-453279 Mitotic G1-G1/S phases 0.991614572808726 -0.00842078267180326 132 12 0.00873998543335761 1373 8688 12571,12579,18974,26440,19177,17463,12443,26443,66998,12447,12545,13548 Cdk6,Cdkn2b,Pole2,Psma1,Psmb7,Psmd7,Ccnd1,Psma6,Psmd5,Ccne1,Cdc7,Dyrk1a R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.991823029639122 -0.00821058515320588 71 5 0.00364166059723234 1373 8688 26443,66998,17463,19177,26440 Psma6,Psmd5,Psmd7,Psmb7,Psma1 R-MMU-6803529 FGFR2 alternative splicing 0.991970440914424 -0.00806196960651573 28 1 0.000728332119446468 1373 8688 93686 Rbfox2 R-MMU-391251 Protein folding 0.991970440914424 -0.00806196960651573 28 1 0.000728332119446468 1373 8688 20698 Sphk1 R-MMU-390466 Chaperonin-mediated protein folding 0.991970440914424 -0.00806196960651573 28 1 0.000728332119446468 1373 8688 20698 Sphk1 R-MMU-109703 PKB-mediated events 0.992573898992238 -0.00745381176969804 41 2 0.00145666423889294 1373 8688 74370,19744 Rptor,Rheb R-MMU-211981 Xenobiotics 0.992573898992238 -0.00745381176969804 41 2 0.00145666423889294 1373 8688 11864,11622 Arnt2,Ahr R-MMU-69300 Removal of licensing factors from origins 0.99275473002645 -0.00727164441254714 72 5 0.00364166059723234 1373 8688 19177,17463,26443,66998,26440 Psmb7,Psmd7,Psma6,Psmd5,Psma1 R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.99324348765031 -0.00677944091570909 29 1 0.000728332119446468 1373 8688 20018 Polr1d R-MMU-211945 Phase 1 - Functionalization of compounds 0.993321634354832 -0.00670076571528694 151 14 0.0101966496722505 1373 8688 13070,11669,15516,13082,14261,13124,232174,11864,11622,18105,19223,13109,19224,20181 Cyp11a1,Aldh2,Hsp90ab1,Cyp26a1,Fmo1,Cyp8b1,Cyp26b1,Arnt2,Ahr,Nqo2,Ptgis,Cyp2j5,Ptgs1,Rxra R-MMU-3108214 SUMOylation of DNA damage response and repair proteins 0.993584604403574 -0.00643606268587598 73 5 0.00364166059723234 1373 8688 56233,19357,11545,71805,67872 Hdac7,Rad21,Parp1,Nup93,Nsmce4a R-MMU-68886 M Phase 0.993871653252436 -0.00614720213888116 247 26 0.0189366351056082 1373 8688 56150,100710,59021,67629,108000,52696,71805,17120,18750,26932,76499,320595,226747,244329,66336,71521,19177,17463,19357,83431,14245,66998,26443,56430,26440,16319 Mad2l1,Pds5b,Rab2a,Spc24,Cenpf,Zwint,Nup93,Mad1l1,Prkca,Ppp2r5e,Clasp2,Phf8,Ahctf1,Mcph1,Cenpp,Pds5a,Psmb7,Psmd7,Rad21,Ndel1,Lpin1,Psmd5,Psma6,Clip1,Psma1,Incenp R-MMU-69206 G1/S Transition 0.994043551092502 -0.00597425930900734 110 9 0.00655498907501821 1373 8688 18974,26440,26443,66998,17463,19177,12443,12545,12447 Pole2,Psma1,Psma6,Psmd5,Psmd7,Psmb7,Ccnd1,Cdc7,Ccne1 R-MMU-390918 Peroxisomal lipid metabolism 0.994314822854711 -0.00570139927789177 30 1 0.000728332119446468 1373 8688 74121 Acoxl R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.994314822854711 -0.00570139927789177 30 1 0.000728332119446468 1373 8688 71805 Nup93 R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.994314822854711 -0.00570139927789177 30 1 0.000728332119446468 1373 8688 20018 Polr1d R-MMU-6781823 Formation of TC-NER Pre-Incision Complex 0.994414910770821 -0.00560074415668319 54 3 0.0021849963583394 1373 8688 13871,71101,108679 Ercc2,Uvssa,Cops8 R-MMU-70153 Glucose transport 0.994516724895923 -0.0054983634379438 43 2 0.00145666423889294 1373 8688 15275,71805 Hk1,Nup93 R-MMU-5620912 Anchoring of the basal body to the plasma membrane 0.994538375576807 -0.00547659362283955 93 7 0.00509832483612527 1373 8688 53869,382090,99100,68642,19088,73738,18005 Rab11a,Cep162,Cep152,Tmem216,Prkar2b,Haus7,Nek2 R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes 0.994979944521517 -0.00503269828646623 75 5 0.00364166059723234 1373 8688 18005,51885,73738,19088,99100 Nek2,Tubgcp4,Haus7,Prkar2b,Cep152 R-MMU-380287 Centrosome maturation 0.994979944521517 -0.00503269828646623 75 5 0.00364166059723234 1373 8688 51885,18005,73738,19088,99100 Tubgcp4,Nek2,Haus7,Prkar2b,Cep152 R-MMU-69304 Regulation of DNA replication 0.994979944521517 -0.00503269828646623 75 5 0.00364166059723234 1373 8688 66998,26443,19177,17463,26440 Psmd5,Psma6,Psmb7,Psmd7,Psma1 R-MMU-72702 Ribosomal scanning and start codon recognition 0.995142245576218 -0.00486959166329677 55 3 0.0021849963583394 1373 8688 267019,217869,68135 Rps15a,Eif5,Eif3h R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence 0.995291500667251 -0.00471961923483081 44 2 0.00145666423889294 1373 8688 16906,12447 Lmnb1,Ccne1 R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.996067834545797 -0.00393991674302169 67 4 0.00291332847778587 1373 8688 73738,18005,99100,19088 Haus7,Nek2,Cep152,Prkar2b R-MMU-380259 Loss of Nlp from mitotic centrosomes 0.996067834545797 -0.00393991674302169 67 4 0.00291332847778587 1373 8688 73738,18005,99100,19088 Haus7,Nek2,Cep152,Prkar2b R-MMU-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.996082503738486 -0.0039251897493729 114 9 0.00655498907501821 1373 8688 20018,234366,208595,15078,21340,15182,17191,13871,75627 Polr1d,Gatad2a,Mterf1b,H3f3a,Taf1b,Hdac2,Mbd2,Ercc2,Snapc1 R-MMU-3371453 Regulation of HSF1-mediated heat shock response 0.996331254283211 -0.00367549206984658 57 3 0.0021849963583394 1373 8688 29810,71805,15511 Bag3,Nup93,Hspa1b R-MMU-69306 DNA Replication 0.996467092474943 -0.00353916298049052 106 8 0.00582665695557174 1373 8688 26440,18974,19177,17463,66998,26443,12545,69263 Psma1,Pole2,Psmb7,Psmd7,Psmd5,Psma6,Cdc7,Rfc3 R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.996477250336153 -0.00352896915721879 115 9 0.00655498907501821 1373 8688 16414,217304,74482,68713,17470,16412,12478,74603,271375 Itgb2,Cd300lb,Ifitm7,Ifitm1,Cd200,Itgb1,Cd19,Cd200r3,Cd200r2 R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.996553640961296 -0.00345231141396532 68 4 0.00291332847778587 1373 8688 18033,12571,15078,12579 Nfkb1,Cdk6,H3f3a,Cdkn2b R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly 0.996613496307831 -0.00339225087470225 33 1 0.000728332119446468 1373 8688 71805 Nup93 R-MMU-69239 Synthesis of DNA 0.996904092173095 -0.00310071006362406 98 7 0.00509832483612527 1373 8688 19177,69263,17463,66998,26443,26440,18974 Psmb7,Rfc3,Psmd7,Psmd5,Psma6,Psma1,Pole2 R-MMU-5617833 Cilium Assembly 0.99697459636006 -0.0030299894251016 168 15 0.010924981791697 1373 8688 238799,73916,213081,73738,18763,13196,19088,382090,319845,333329,53869,76260,18005,68642,99100 Tnpo1,Ift57,Wdr19,Haus7,Pkd1,Asap1,Prkar2b,Cep162,Bbs9,Cngb1,Rab11a,Ttc8,Nek2,Tmem216,Cep152 R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.997026213181304 -0.00297821730845236 47 2 0.00145666423889294 1373 8688 242425,14816 Gabbr2,Grm1 R-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane 0.997055241299521 -0.00294910303315159 89 6 0.00436999271667881 1373 8688 217337,68436,19981,20813,267019,56040 Srp68,Rpl34,Rpl37a,Srp14,Rps15a,Rplp1 R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.997073872315741 -0.00293041716562852 143 12 0.00873998543335761 1373 8688 80879,22228,28080,56451,381511,68194,106557,20181,76826,11957,18115,68263 Slc16a3,Ucp2,Atp5o,Suclg1,Pdp1,Ndufb4,Ldhal6b,Rxra,Nubpl,Atp5j,Nnt,Pdhb R-MMU-3214858 RMTs methylate histone arginines 0.99735710893903 -0.00264638966319254 70 4 0.00291332847778587 1373 8688 20588,13435,66993,12443 Smarcc1,Dnmt3a,Smarcd3,Ccnd1 R-MMU-8854518 AURKA Activation by TPX2 0.99735710893903 -0.00264638966319254 70 4 0.00291332847778587 1373 8688 73738,18005,99100,19088 Haus7,Nek2,Cep152,Prkar2b R-MMU-189200 Hexose transport 0.997450582428624 -0.00255267287027366 48 2 0.00145666423889294 1373 8688 15275,71805 Hk1,Nup93 R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.997450582428624 -0.00255267287027366 48 2 0.00145666423889294 1373 8688 68135,267019 Eif3h,Rps15a R-MMU-5250941 Negative epigenetic regulation of rRNA expression 0.99754305059162 -0.00245997266157991 100 7 0.00509832483612527 1373 8688 21340,17191,20018,51788,15078,15182,93762 Taf1b,Mbd2,Polr1d,H2afz,H3f3a,Hdac2,Smarca5 R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 0.997602772262137 -0.00240010568859843 35 1 0.000728332119446468 1373 8688 15078 H3f3a R-MMU-2262752 Cellular responses to stress 0.997683648654985 -0.00231903823678383 360 39 0.0284049526584122 1373 8688 15078,19177,18033,26443,29810,12571,29806,17684,74370,12447,71805,12359,16906,17248,16476,74244,26399,20657,57436,15251,108058,67443,75608,17463,23871,50490,66998,26440,15511,17969,26416,15516,19744,68196,52639,12579,112407,14778,66734 H3f3a,Psmb7,Nfkb1,Psma6,Bag3,Cdk6,Limd1,Cited2,Rptor,Ccne1,Nup93,Cat,Lmnb1,Mdm4,Jun,Atg7,Map2k6,Sod3,Gabarapl1,Hif1a,Camk2d,Map1lc3b,Chmp4b,Psmd7,Ets1,Nox4,Psmd5,Psma1,Hspa1b,Ncf1,Mapk14,Hsp90ab1,Rheb,Hsbp1,Wipi1,Cdkn2b,Egln3,Gpx3,Map1lc3a R-MMU-427413 NoRC negatively regulates rRNA expression 0.997951352022689 -0.00205074932701934 92 6 0.00436999271667881 1373 8688 15182,93762,15078,51788,20018,17191 Hdac2,Smarca5,H3f3a,H2afz,Polr1d,Mbd2 R-MMU-212165 Epigenetic regulation of gene expression 0.99798263869588 -0.00201939891829916 138 11 0.00801165331391114 1373 8688 11569,214133,93762,51788,17191,15182,21340,13435,11461,15078,20018 Aebp2,Tet2,Smarca5,H2afz,Mbd2,Hdac2,Taf1b,Dnmt3a,Actb,H3f3a,Polr1d R-MMU-5389840 Mitochondrial translation elongation 0.998162701760725 -0.0018389881419055 83 5 0.00364166059723234 1373 8688 68537,94062,66230,52443,66845 Mrpl13,Mrpl3,Mrps28,Mrpl48,Mrpl33 R-MMU-211859 Biological oxidations 0.99816910649338 -0.00183257164077264 231 22 0.0160233066278223 1373 8688 13109,108645,216558,18105,107146,11622,13082,68214,19224,20181,23971,19223,23972,15516,13124,14261,232174,11864,13885,11669,13070,211666 Cyp2j5,Mat2b,Ugp2,Nqo2,Glyat,Ahr,Cyp26a1,Gsto2,Ptgs1,Rxra,Papss1,Ptgis,Papss2,Hsp90ab1,Cyp8b1,Fmo1,Cyp26b1,Arnt2,Esd,Aldh2,Cyp11a1,Mgst2 R-MMU-2559583 Cellular Senescence 0.99818086873711 -0.00182078789155422 139 11 0.00801165331391114 1373 8688 18033,23871,16476,17248,16906,12571,12579,26416,26399,12447,15078 Nfkb1,Ets1,Jun,Mdm4,Lmnb1,Cdk6,Cdkn2b,Mapk14,Map2k6,Ccne1,H3f3a R-MMU-191859 snRNP Assembly 0.998397185852668 -0.00160410002812948 51 2 0.00145666423889294 1373 8688 71805,53975 Nup93,Ddx20 R-MMU-194441 Metabolism of non-coding RNA 0.998397185852668 -0.00160410002812948 51 2 0.00145666423889294 1373 8688 53975,71805 Ddx20,Nup93 R-MMU-5419276 Mitochondrial translation termination 0.998578816512312 -0.00142219432677998 85 5 0.00364166059723234 1373 8688 66845,52443,66230,68537,94062 Mrpl33,Mrpl48,Mrps28,Mrpl13,Mrpl3 R-MMU-5368287 Mitochondrial translation 0.998751027247033 -0.00124975336948268 86 5 0.00364166059723234 1373 8688 52443,66845,94062,68537,66230 Mrpl48,Mrpl33,Mrpl3,Mrpl13,Mrps28 R-MMU-166658 Complement cascade 0.998799088004831 -0.001201633667814 39 1 0.000728332119446468 1373 8688 239447 Colec10 R-MMU-5578749 Transcriptional regulation by small RNAs 0.998823089765673 -0.00117760333704314 76 4 0.00291332847778587 1373 8688 239528,71805,233833,15078 Ago2,Nup93,Tnrc6a,H3f3a R-MMU-3214847 HATs acetylate histones 0.998973303914132 -0.0010272234993204 77 4 0.00291332847778587 1373 8688 228829,18505,54169,15078 Phf20,Pax3,Kat6b,H3f3a R-MMU-72649 Translation initiation complex formation 0.998995369293765 -0.0010051356859035 54 2 0.00145666423889294 1373 8688 267019,68135 Rps15a,Eif3h R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.999036801227035 -0.000963662946987954 88 5 0.00364166059723234 1373 8688 56040,267019,19981,19704,68436 Rplp1,Rps15a,Rpl37a,Upf1,Rpl34 R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.999140770197758 -0.000859599151754405 55 2 0.00145666423889294 1373 8688 267019,68135 Rps15a,Eif3h R-MMU-573389 NoRC negatively regulates rRNA expression 0.999349995513166 -0.00065021583133894 91 5 0.00364166059723234 1373 8688 93762,15182,20018,51788,15078 Smarca5,Hdac2,Polr1d,H2afz,H3f3a R-MMU-6799198 Complex I biogenesis 0.999463388175117 -0.000536755852535623 58 2 0.00145666423889294 1373 8688 68194,76826 Ndufb4,Nubpl R-MMU-2132295 MHC class II antigen presentation 0.999563124550015 -0.000436970907867452 94 5 0.00364166059723234 1373 8688 99683,14961,22428,218275,16593 Sec24b,H2-Ab1,Dctn6,BC051665,Klc1 R-MMU-4570464 SUMOylation of RNA binding proteins 0.99957447045258 -0.000425620110810031 45 1 0.000728332119446468 1373 8688 71805 Nup93 R-MMU-72312 rRNA processing 0.99960355048893 -0.000396528117954286 125 8 0.00582665695557174 1373 8688 73674,215193,68436,19981,57316,216987,67276,56040 Wdr75,Utp25,Rpl34,Rpl37a,C1d,Utp6,Eri1,Rplp1 R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.99960355048893 -0.000396528117954286 125 8 0.00582665695557174 1373 8688 73674,68436,215193,67276,216987,56040,19981,57316 Wdr75,Rpl34,Utp25,Eri1,Utp6,Rplp1,Rpl37a,C1d R-MMU-8868773 rRNA processing in the nucleus and cytosol 0.99960355048893 -0.000396528117954286 125 8 0.00582665695557174 1373 8688 19981,57316,67276,56040,216987,215193,68436,73674 Rpl37a,C1d,Eri1,Rplp1,Utp6,Utp25,Rpl34,Wdr75 R-MMU-6803157 Antimicrobial peptides 0.999608469376371 -0.000391607291756412 60 2 0.00145666423889294 1373 8688 12652,24088 Chga,Tlr2 R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition 0.999610087517378 -0.000389988518259208 84 4 0.00291332847778587 1373 8688 18005,73738,19088,99100 Nek2,Haus7,Prkar2b,Cep152 R-MMU-72689 Formation of a pool of free 40S subunits 0.999617647296565 -0.00038242581886791 95 5 0.00364166059723234 1373 8688 19981,267019,56040,68135,68436 Rpl37a,Rps15a,Rplp1,Eif3h,Rpl34 R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.999642068761309 -0.000357995311365945 46 1 0.000728332119446468 1373 8688 13871 Ercc2 R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.999642068761309 -0.000357995311365945 46 1 0.000728332119446468 1373 8688 13871 Ercc2 R-MMU-73776 RNA Polymerase II Promoter Escape 0.999642068761309 -0.000357995311365945 46 1 0.000728332119446468 1373 8688 13871 Ercc2 R-MMU-75953 RNA Polymerase II Transcription Initiation 0.999642068761309 -0.000357995311365945 46 1 0.000728332119446468 1373 8688 13871 Ercc2 R-MMU-1221632 Meiotic synapsis 0.999645351277361 -0.000354711625370093 106 6 0.00436999271667881 1373 8688 77053,19357,64009,16906,51788,15078 Sun1,Rad21,Syne1,Lmnb1,H2afz,H3f3a R-MMU-1221633 Meiotic Synapsis 0.999645351277361 -0.000354711625370093 106 6 0.00436999271667881 1373 8688 16906,15078,51788,64009,19357,77053 Lmnb1,H3f3a,H2afz,Syne1,Rad21,Sun1 R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.999645351277361 -0.000354711625370093 106 6 0.00436999271667881 1373 8688 217869,19981,56040,267019,68135,68436 Eif5,Rpl37a,Rplp1,Rps15a,Eif3h,Rpl34 R-MMU-3247509 Chromatin modifying enzymes 0.999675255909303 -0.000324796831477976 191 15 0.010924981791697 1373 8688 320595,69726,54169,14013,15078,225888,13435,12443,66993,18505,11569,228829,18033,226830,20588 Phf8,Smyd3,Kat6b,Mecom,H3f3a,Kmt5b,Dnmt3a,Ccnd1,Smarcd3,Pax3,Aebp2,Phf20,Nfkb1,Smyd2,Smarcc1 R-MMU-4839726 Chromatin organization 0.999675255909303 -0.000324796831477976 191 15 0.010924981791697 1373 8688 54169,14013,320595,69726,13435,15078,225888,228829,18033,11569,18505,12443,66993,20588,226830 Kat6b,Mecom,Phf8,Smyd3,Dnmt3a,H3f3a,Kmt5b,Phf20,Nfkb1,Aebp2,Pax3,Ccnd1,Smarcd3,Smarcc1,Smyd2 R-MMU-69275 G2/M Transition 0.999702367148979 -0.000297677152468361 165 12 0.00873998543335761 1373 8688 19088,73738,15516,26440,99100,51885,18005,21664,66998,26443,17463,19177 Prkar2b,Haus7,Hsp90ab1,Psma1,Cep152,Tubgcp4,Nek2,Phlda1,Psmd5,Psma6,Psmd7,Psmb7 R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.999707492621627 -0.000292550167000174 97 5 0.00364166059723234 1373 8688 28080,11957,22228,76826,68194 Atp5o,Atp5j,Ucp2,Nubpl,Ndufb4 R-MMU-5250913 Positive epigenetic regulation of rRNA expression 0.99972594950007 -0.000274088058630822 108 6 0.00436999271667881 1373 8688 21340,11461,20018,15078,51788,93762 Taf1b,Actb,Polr1d,H3f3a,H2afz,Smarca5 R-MMU-927802 Nonsense-Mediated Decay (NMD) 0.99972594950007 -0.000274088058630822 108 6 0.00436999271667881 1373 8688 19981,19704,267019,56040,71997,68436 Rpl37a,Upf1,Rps15a,Rplp1,Smg9,Rpl34 R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.99972594950007 -0.000274088058630822 108 6 0.00436999271667881 1373 8688 71997,68436,19704,19981,267019,56040 Smg9,Rpl34,Upf1,Rpl37a,Rps15a,Rplp1 R-MMU-453274 Mitotic G2-G2/M phases 0.999760709381658 -0.000239319252910614 167 12 0.00873998543335761 1373 8688 15516,73738,19088,17463,19177,66998,26443,18005,21664,51885,99100,26440 Hsp90ab1,Haus7,Prkar2b,Psmd7,Psmb7,Psmd5,Psma6,Nek2,Phlda1,Tubgcp4,Cep152,Psma1 R-MMU-72766 Translation 0.999783182595094 -0.00021684091319782 130 8 0.00582665695557174 1373 8688 68436,68135,56040,267019,20813,19981,217337,217869 Rpl34,Eif3h,Rplp1,Rps15a,Srp14,Rpl37a,Srp68,Eif5 R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.999787013386111 -0.000213009298758987 49 1 0.000728332119446468 1373 8688 99683 Sec24b R-MMU-5619507 Activation of HOX genes during differentiation 0.999808071563752 -0.000191946856866922 131 8 0.00582665695557174 1373 8688 15078,13654,19401,51788,20181,16476,218772,18771 H3f3a,Egr2,Rara,H2afz,Rxra,Jun,Rarb,Pknox1 R-MMU-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0.999808071563752 -0.000191946856866922 131 8 0.00582665695557174 1373 8688 18771,218772,16476,20181,51788,19401,13654,15078 Pknox1,Rarb,Jun,Rxra,H2afz,Rara,Egr2,H3f3a R-MMU-5334118 DNA methylation 0.999827338374856 -0.000172676532878698 78 3 0.0021849963583394 1373 8688 13435,51788,15078 Dnmt3a,H2afz,H3f3a R-MMU-72737 Cap-dependent Translation Initiation 0.999837152566589 -0.000162860694494437 112 6 0.00436999271667881 1373 8688 68135,68436,19981,217869,56040,267019 Eif3h,Rpl34,Rpl37a,Eif5,Rplp1,Rps15a R-MMU-72613 Eukaryotic Translation Initiation 0.999837152566589 -0.000162860694494437 112 6 0.00436999271667881 1373 8688 267019,56040,19981,217869,68436,68135 Rps15a,Rplp1,Rpl37a,Eif5,Rpl34,Eif3h R-MMU-3214842 HDMs demethylate histones 0.999849337015181 -0.000150674335626943 51 1 0.000728332119446468 1373 8688 320595 Phf8 R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.999886852635922 -0.00011315376572378 104 5 0.00364166059723234 1373 8688 68436,68135,56040,267019,19981 Rpl34,Eif3h,Rplp1,Rps15a,Rpl37a R-MMU-372790 Signaling by GPCR 0.999912159303059 -8.78445551609052e-05 1331 166 0.120903131828114 1373 8688 50780,21844,239766,622434,17967,241489,319229,12801,24001,109648,18795,432530,19088,14083,74769,19227,12778,26932,16440,114715,14675,29863,230972,18590,19084,19177,26443,211323,223435,107221,14816,13618,11852,15557,71111,14183,13609,13649,11551,13051,11554,258922,16706,19220,23984,19414,54611,320129,269608,18155,240168,213527,13615,13610,83961,18619,80903,239283,545156,235584,19228,18783,18573,51801,14182,13614,11535,11515,18583,213649,12424,18430,12919,12314,11876,230857,240672,18753,14773,14173,108058,18708,19735,24111,12062,80901,14811,12326,67603,20297,17311,19419,218397,70839,26440,16443,18584,237880,84112,277360,56183,104111,269060,208188,13617,50501,23945,18607,14180,18798,210044,14526,54126,110157,320127,12767,75547,11820,57257,15559,11513,14164,11539,30938,19262,14163,18441,20741,258330,71704,17463,17329,12313,66998,20742,20315,258426,20604,19878,18578,16439,17295,238871,14172,16183,54199,67653,11606,110197,69601,225192,171530,16438,13616,258151,102098,140795,239530,242425,11549,18755,11548,13869,26946,16591,18750 Rgs3,Tiam1,Rtp1,Arhgef26,Ncam1,Pde11a,Sctr,Cnr1,Tiam2,Npy,Plcb1,Adcy1,Prkar2b,Ptk2,Pik3cb,Pthlh,Ackr3,Ppp2r5e,Itpr3,Spred1,Gna14,Pde7b,Arhgef16,Pdgfa,Prkar1a,Psmb7,Psma6,Nrg1,Trio,Ffar4,Grm1,Ednrb,Rhob,Htr1f,Gpr39,Fgfr2,S1pr1,Egfr,Adra2a,Cx3cr1,Adrb1,Olfr267,Ksr1,Ptgfr,Pde10a,Rasa3,Pde3a,Grk3,Plekhg5,Pnoc,Rasgrp3,Pth2r,Edn2,S1pr3,Nrg4,Penk,Fgf16,Oxgr1,Kalrn,Dusp7,Pth1r,Pla2g4a,Pde1a,Ramp1,Fgfr1,Edn1,Adm,Adcy9,Pde7a,Arhgef19,Cck,Oxtr,Crhbp,Calm2,Artn,Ece1,Dusp5,Prkcd,Grk5,Fgf2,Camk2d,Pik3r1,Rgs2,Uts2,Bdkrb2,Cxcr6,Grin2a,Camk4,Dusp6,Ccl20,Kitl,Rasgrp1,Rasa1,P2ry12,Psma1,Itsn1,Pde8a,1700071K01Rik,Sucnr1,Prex1,Nmu,Adcy3,Dagla,Ghsr,Ednra,Prok2,Mgll,Pdpk1,Fgf9,Plcb4,Adcy2,Gcg,Arhgef7,Raf1,Dgki,Cxcr4,Akap13,App,Vav3,Htr2b,Adcy7,Fgf1,Adora1,Fgd3,Ptpra,Fgd1,P2ry1,Sptb,Olfr1274-ps,Arhgef3,Psmd7,Cxcl9,Calm1,Psmd5,Sptbn1,Cxcl12,Olfr995,Sst,Rock2,Pde4b,Itpr2,Met,Pde4d,Fgf18,Il2,Ccrl2,4930544G11Rik,Agt,Dgkg,Dab2ip,Hrh4,Ucn2,Itpr1,Edn3,Olfr1505,Arhgef18,P2ry14,Gpr20,Gabbr2,Adra1a,Prkch,Adra1b,Erbb4,Trpc7,Kl,Prkca R-MMU-1852241 Organelle biogenesis and maintenance 0.999931669449618 -6.83328850206994e-05 276 23 0.0167516387472688 1373 8688 76260,18005,68537,213081,26415,13196,66845,52443,319845,382090,333329,66230,53869,94062,68642,99100,73916,238799,26416,19017,73738,19088,18763 Ttc8,Nek2,Mrpl13,Wdr19,Mapk13,Asap1,Mrpl33,Mrpl48,Bbs9,Cep162,Cngb1,Mrps28,Rab11a,Mrpl3,Tmem216,Cep152,Ift57,Tnpo1,Mapk14,Ppargc1a,Haus7,Prkar2b,Pkd1 R-MMU-72202 Transport of Mature Transcript to Cytoplasm 0.999932004468228 -6.7997843573255e-05 71 2 0.00145666423889294 1373 8688 71805,56488 Nup93,Nxt1 R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.999932004468228 -6.7997843573255e-05 71 2 0.00145666423889294 1373 8688 71805,56488 Nup93,Nxt1 R-MMU-73857 RNA Polymerase II Transcription 0.999956867586141 -4.31333440883866e-05 143 8 0.00582665695557174 1373 8688 20924,72949,70122,67655,24116,13716,235497,13871 Supt5,Ccnt2,Mllt3,Ctdp1,Nelfa,Ell,Leo1,Ercc2 R-MMU-611105 Respiratory electron transport 0.999958000895958 -4.19999860290748e-05 74 2 0.00145666423889294 1373 8688 76826,68194 Nubpl,Ndufb4 R-MMU-69278 Cell Cycle, Mitotic 0.999960502194521 -3.94985855380527e-05 438 42 0.0305899490167516 1373 8688 26443,83431,19357,19177,56430,18005,12571,320595,26932,13548,66336,244329,229776,17120,52696,71805,108000,12443,99100,18750,18974,56150,67629,12447,73738,66998,14245,17463,16319,26440,51885,76499,69263,71521,226747,12545,12579,21664,19088,59021,100710,15516 Psma6,Ndel1,Rad21,Psmb7,Clip1,Nek2,Cdk6,Phf8,Ppp2r5e,Dyrk1a,Cenpp,Mcph1,Cdc14a,Mad1l1,Zwint,Nup93,Cenpf,Ccnd1,Cep152,Prkca,Pole2,Mad2l1,Spc24,Ccne1,Haus7,Psmd5,Lpin1,Psmd7,Incenp,Psma1,Tubgcp4,Clasp2,Rfc3,Pds5a,Ahctf1,Cdc7,Cdkn2b,Phlda1,Prkar2b,Rab2a,Pds5b,Hsp90ab1 R-MMU-1500620 Meiosis 0.999962257456649 -3.77432556188637e-05 123 6 0.00436999271667881 1373 8688 64009,15078,51788,16906,77053,19357 Syne1,H3f3a,H2afz,Lmnb1,Sun1,Rad21 R-MMU-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.999964245241149 -3.57553980678228e-05 75 2 0.00145666423889294 1373 8688 51788,15078 H2afz,H3f3a R-MMU-211000 Gene Silencing by RNA 0.999980811294382 -1.91888897231562e-05 105 4 0.00291332847778587 1373 8688 15078,233833,239528,71805 H3f3a,Tnrc6a,Ago2,Nup93 R-MMU-6805567 Keratinization 0.999982359268828 -1.7640886771952e-05 150 8 0.00582665695557174 1373 8688 71529,12336,75706,223917,18772,69664,16480,76560 Kazn,Capns1,Krt24,Krt79,Pkp1,Krtap1-5,Jup,Prss8 R-MMU-1640170 Cell Cycle 0.999996801520976 -3.19848413953921e-06 596 58 0.0422432629278951 1373 8688 26443,83431,19177,19357,70620,12571,18005,51788,56430,12021,66311,26932,320595,244329,66336,13548,64009,229776,107976,15078,71805,52696,17120,12443,108000,18750,18974,17248,99100,16906,56150,12447,67629,73738,66998,17463,14245,93762,26440,16319,51885,69263,76499,12545,226747,22631,71521,223970,77053,27223,21664,12579,19088,59021,225182,22630,100710,15516 Psma6,Ndel1,Psmb7,Rad21,Ube2v2,Cdk6,Nek2,H2afz,Clip1,Bard1,Cenpw,Ppp2r5e,Phf8,Mcph1,Cenpp,Dyrk1a,Syne1,Cdc14a,Babam2,H3f3a,Nup93,Zwint,Mad1l1,Ccnd1,Cenpf,Prkca,Pole2,Mdm4,Cep152,Lmnb1,Mad2l1,Ccne1,Spc24,Haus7,Psmd5,Psmd7,Lpin1,Smarca5,Psma1,Incenp,Tubgcp4,Rfc3,Clasp2,Cdc7,Ahctf1,Ywhaz,Pds5a,Rmi2,Sun1,Trp53bp1,Phlda1,Cdkn2b,Prkar2b,Rab2a,Rbbp8,Ywhaq,Pds5b,Hsp90ab1 R-MMU-912497 Meiotic Recombination 0.999997337034748 -2.66296879741027e-06 91 2 0.00145666423889294 1373 8688 51788,15078 H2afz,H3f3a R-MMU-74160 Gene Expression 0.99999909476534 -9.0523507010453e-07 1163 131 0.0954115076474873 1373 8688 17463,18667,66998,20393,50783,21388,13865,26399,15182,20813,69305,77976,140742,22631,18130,67655,19981,80707,214133,20602,13716,68592,68135,26416,267019,21834,13197,19883,53975,17191,106931,227743,67276,21340,71702,71805,18750,26424,72949,67285,70122,56488,20620,66373,18129,16009,26440,218333,11545,11461,56040,15258,19664,18607,20481,270118,22061,433586,21981,19401,12021,67279,13435,26423,67678,18128,12177,63856,21815,208595,20018,93762,70640,17127,13982,57316,217337,24116,20924,101861,19704,22630,21676,235497,68436,68975,239528,71997,15378,104625,18753,110532,12192,215193,17684,192657,74370,14660,73674,69181,78651,68428,14815,217869,56417,69263,223970,11569,20181,15511,19744,74747,225182,18718,233833,75627,19177,228829,26443,51788,15078,234366,216987,97064,218772,226830,17248,13871,69790,11737,12447 Psmd7,Pgr,Psmd5,Sgk1,Lsm4,Tbx5,Nr2f1,Map2k6,Hdac2,Srp14,Dcps,Nuak1,Sesn1,Ywhaz,Ints6,Ctdp1,Rpl37a,Wwox,Tet2,Ncor2,Ell,Syf2,Eif3h,Mapk14,Rps15a,Thrb,Gadd45a,Rora,Ddx20,Mbd2,Kctd1,Mapkap1,Eri1,Taf1b,Cdc5l,Nup93,Prkca,Nr5a2,Ccnt2,Cwc27,Mllt3,Nxt1,Plk2,Lsm5,Notch2,Igfbp3,Psma1,Ice1,Parp1,Actb,Rplp1,Hipk2,Rbpj,Pdpk1,Ski,Maml2,Trp63,Maml3,Ppp1r13b,Rara,Bard1,Med31,Dnmt3a,Nr5a1,Lsm3,Notch1,Bnip3l,Taf8,Tgif1,Mterf1b,Polr1d,Smarca5,Dcp2,Smad3,Esr1,C1d,Srp68,Nelfa,Supt5,Ints4,Upf1,Ywhaq,Tead1,Leo1,Rpl34,Med27,Ago2,Smg9,Hnf4a,Cnot6,Prkcd,Adarb1,Zfp36l1,Utp25,Cited2,Ell2,Rptor,Gls,Wdr75,Dyrk2,Lsm6,Steap3,Nr3c1,Eif5,Adar,Rfc3,Rmi2,Aebp2,Rxra,Hspa1b,Rheb,Ddit4,Rbbp8,Pip4k2a,Tnrc6a,Snapc1,Psmb7,Phf20,Psma6,H2afz,H3f3a,Gatad2a,Utp6,Wwtr1,Rarb,Smyd2,Mdm4,Ercc2,Med30,Anp32a,Ccne1 R-MMU-72163 mRNA Splicing - Major Pathway 0.999999764104859 -2.35895168537415e-07 171 7 0.00509832483612527 1373 8688 67678,68592,50783,78651,66373,67285,71702 Lsm3,Syf2,Lsm4,Lsm6,Lsm5,Cwc27,Cdc5l R-MMU-72172 mRNA Splicing 0.999999934034015 -6.59659876776678e-08 180 7 0.00509832483612527 1373 8688 71702,66373,67285,78651,67678,68592,50783 Cdc5l,Lsm5,Cwc27,Lsm6,Lsm3,Syf2,Lsm4 R-MMU-388396 GPCR downstream signaling 0.999999970895368 -2.9104632210165e-08 1065 111 0.0808448652585579 1373 8688 50780,14773,24111,18708,19735,21844,20297,239766,12062,80901,12801,319229,241489,70839,622434,18584,109648,24001,16443,432530,18795,84112,277360,104111,19227,12778,74769,56183,13617,208188,16440,269060,230972,29863,50501,14675,18798,18607,23945,223435,14816,54126,14526,210044,75547,12767,320127,15557,11852,11820,57257,13618,13609,11539,11513,15559,11551,30938,14163,11554,258922,269608,258330,18155,320129,54611,23984,19220,18441,213527,17329,71704,258426,13615,20315,18619,16439,13610,18578,19878,20604,239283,16183,238871,51801,18573,545156,19228,11606,67653,11515,11535,13614,225192,110197,18583,258151,12424,18430,13616,16438,213649,102098,140795,11549,242425,18753,239530,26946,11548,18755 Rgs3,Grk5,Uts2,Pik3r1,Rgs2,Tiam1,Ccl20,Rtp1,Bdkrb2,Cxcr6,Cnr1,Sctr,Pde11a,P2ry12,Arhgef26,Pde8a,Npy,Tiam2,Itsn1,Adcy1,Plcb1,Sucnr1,Prex1,Adcy3,Pthlh,Ackr3,Pik3cb,Nmu,Ednra,Ghsr,Itpr3,Dagla,Arhgef16,Pde7b,Prok2,Gna14,Plcb4,Pdpk1,Mgll,Trio,Grm1,Arhgef7,Gcg,Adcy2,Akap13,Cxcr4,Dgki,Htr1f,Rhob,App,Vav3,Ednrb,S1pr1,Adora1,Adcy7,Htr2b,Adra2a,Fgd3,Fgd1,Adrb1,Olfr267,Plekhg5,Olfr1274-ps,Pnoc,Grk3,Pde3a,Pde10a,Ptgfr,P2ry1,Pth2r,Cxcl9,Arhgef3,Olfr995,Edn2,Cxcl12,Penk,Itpr2,S1pr3,Pde4b,Rock2,Sst,Oxgr1,Il2,Pde4d,Ramp1,Pde1a,Kalrn,Pth1r,Agt,4930544G11Rik,Adcy9,Adm,Edn1,Hrh4,Dgkg,Pde7a,Olfr1505,Cck,Oxtr,Edn3,Itpr1,Arhgef19,Arhgef18,P2ry14,Adra1a,Gabbr2,Prkcd,Gpr20,Trpc7,Adra1b,Prkch R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA 0.999999998705597 -1.29440265156452e-09 231 9 0.00655498907501821 1373 8688 50783,68592,78651,66373,71805,71702,67678,56488,67285 Lsm4,Syf2,Lsm6,Lsm5,Nup93,Cdc5l,Lsm3,Nxt1,Cwc27 R-MMU-381753 Olfactory Signaling Pathway 0.999999999932143 -6.78573771289253e-11 535 5 0.00364166059723234 1373 8688 258151,239766,258922,258330,258426 Olfr1505,Rtp1,Olfr267,Olfr1274-ps,Olfr995