TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols mmu00240 Pyrimidine metabolism 0.906294496530045 -0.0983909743992397 104 23 0.0104497955474784 2201 8063 20018,18605,320685,80914,68106,56520,70881,22247,76952,12497,78929,76654,72269,18103,209558,18972,70428,67486,22245,23959,110074,18974,103149 Polr1d,Enpp1,Dctd,Uck2,Nt5c3b,Nme4,Nt5c1b,Umps,Nt5c2,Entpd6,Polr3h,Upp2,Cda,Nme2,Enpp3,Pold2,Polr3b,Polr3g,Uck1,Nt5e,Dut,Pole2,Upb1 ko00240 Pyrimidine metabolism 0.906294496530045 -0.0983909743992397 104 23 0.0104497955474784 2201 8063 18605,20018,80914,320685,68106,22247,76952,70881,56520,78929,12497,76654,72269,18972,209558,18103,23959,22245,67486,70428,110074,18974,103149 Enpp1,Polr1d,Uck2,Dctd,Nt5c3b,Umps,Nt5c2,Nt5c1b,Nme4,Polr3h,Entpd6,Upp2,Cda,Pold2,Enpp3,Nme2,Nt5e,Uck1,Polr3g,Polr3b,Dut,Pole2,Upb1 mmu_M00094 Ceramide biosynthesis 0.906941332944483 -0.0976775134898954 13 2 0.000908677873693776 2201 8063 241447,228677 Cers6,Sptlc3 mmu_M00002 Glycolysis, core module involving three-carbon compounds 0.906941332944483 -0.0976775134898954 13 2 0.000908677873693776 2201 8063 13806,13808 Eno1,Eno3 M00002 Glycolysis, core module involving three-carbon compounds 0.906941332944483 -0.0976775134898954 13 2 0.000908677873693776 2201 8063 13808,13806 Eno3,Eno1 M00094 Ceramide biosynthesis 0.906941332944483 -0.0976775134898954 13 2 0.000908677873693776 2201 8063 228677,241447 Sptlc3,Cers6 M00087 beta-Oxidation 0.906941332944483 -0.0976775134898954 13 2 0.000908677873693776 2201 8063 52538,15107 Acaa2,Hadh mmu_M00087 beta-Oxidation 0.906941332944483 -0.0976775134898954 13 2 0.000908677873693776 2201 8063 52538,15107 Acaa2,Hadh ko00591 Linoleic acid metabolism 0.910455603662254 -0.093810141396213 50 10 0.00454338936846888 2201 8063 18782,232889,18783,18780,18784,18778,225845,13109,665270,26970 Pla2g2d,Pla2g4c,Pla2g4a,Pla2g2a,Pla2g5,Pla2g1b,Plaat3,Cyp2j5,Plb1,Pla2g2e mmu00591 Linoleic acid metabolism 0.910455603662254 -0.093810141396213 50 10 0.00454338936846888 2201 8063 225845,18778,26970,13109,665270,232889,18782,18780,18784,18783 Plaat3,Pla2g1b,Pla2g2e,Cyp2j5,Plb1,Pla2g4c,Pla2g2d,Pla2g2a,Pla2g5,Pla2g4a mmu00480 Glutathione metabolism 0.915167178844321 -0.0886485212764179 59 12 0.00545206724216265 2201 8063 110208,14782,68396,15926,68214,211666,269951,18263,16790,20603,54486,14778 Pgd,Gsr,Nat8,Idh1,Gsto2,Mgst2,Idh2,Odc1,Anpep,Sms,Hpgds,Gpx3 ko00480 Glutathione metabolism 0.915167178844321 -0.0886485212764179 59 12 0.00545206724216265 2201 8063 269951,211666,68214,15926,68396,110208,14782,16790,14778,20603,54486,18263 Idh2,Mgst2,Gsto2,Idh1,Nat8,Pgd,Gsr,Anpep,Gpx3,Sms,Hpgds,Odc1 mmu_M00687 MAPK (ERK1/2) signaling 0.922048127533079 -0.0811578577281279 8 1 0.000454338936846888 2201 8063 110157 Raf1 M00044 Tyrosine degradation, tyrosine => homogentisate 0.922048127533079 -0.0811578577281279 8 1 0.000454338936846888 2201 8063 100470 Lao1 mmu_M00044 Tyrosine degradation, tyrosine => homogentisate 0.922048127533079 -0.0811578577281279 8 1 0.000454338936846888 2201 8063 100470 Lao1 M00687 MAPK (ERK1/2) signaling 0.922048127533079 -0.0811578577281279 8 1 0.000454338936846888 2201 8063 110157 Raf1 ko00100 Steroid biosynthesis 0.924756698781124 -0.0782246044124642 19 3 0.00136301681054066 2201 8063 20652,66234,235293 Soat1,Msmo1,Sc5d mmu00100 Steroid biosynthesis 0.924756698781124 -0.0782246044124642 19 3 0.00136301681054066 2201 8063 20652,66234,235293 Soat1,Msmo1,Sc5d ko00670 One carbon pool by folate 0.924756698781124 -0.0782246044124642 19 3 0.00136301681054066 2201 8063 108147,270685,17768 Atic,Mthfd1l,Mthfd2 mmu00670 One carbon pool by folate 0.924756698781124 -0.0782246044124642 19 3 0.00136301681054066 2201 8063 17768,270685,108147 Mthfd2,Mthfd1l,Atic mmu_M00129 Ascorbate biosynthesis, animals, glucose-1P => ascorbate 0.926089499154904 -0.0767843976512114 24 4 0.00181735574738755 2201 8063 216558,22235,16591,394433 Ugp2,Ugdh,Kl,Ugt1a5 M00129 Ascorbate biosynthesis, animals, glucose-1P => ascorbate 0.926089499154904 -0.0767843976512114 24 4 0.00181735574738755 2201 8063 216558,16591,394433,22235 Ugp2,Kl,Ugt1a5,Ugdh mmu_M00147 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 0.928056471856092 -0.0746626947542203 14 2 0.000908677873693776 2201 8063 66916,68194 Ndufb7,Ndufb4 mmu_M00055 N-glycan precursor biosynthesis 0.928056471856092 -0.0746626947542203 14 2 0.000908677873693776 2201 8063 66789,320302 Alg14,Glt28d2 M00147 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 0.928056471856092 -0.0746626947542203 14 2 0.000908677873693776 2201 8063 68194,66916 Ndufb4,Ndufb7 M00055 N-glycan precursor biosynthesis 0.928056471856092 -0.0746626947542203 14 2 0.000908677873693776 2201 8063 320302,66789 Glt28d2,Alg14 mmu_M00154 Cytochrome c oxidase 0.939977848170531 -0.0618989697717954 25 4 0.00181735574738755 2201 8063 20463,70383,84682,12864 Cox7a2l,Cox10,Cox4i2,Cox6c M00154 Cytochrome c oxidase 0.939977848170531 -0.0618989697717954 25 4 0.00181735574738755 2201 8063 20463,70383,84682,12864 Cox7a2l,Cox10,Cox4i2,Cox6c M00340 Proteasome, 20S core particle 0.94458341620947 -0.0570112780902106 15 2 0.000908677873693776 2201 8063 26440,26443 Psma1,Psma6 mmu_M00340 Proteasome, 20S core particle 0.94458341620947 -0.0570112780902106 15 2 0.000908677873693776 2201 8063 26443,26440 Psma6,Psma1 ko03030 DNA replication 0.944643429437392 -0.0569477460394353 35 6 0.00272603362108133 2201 8063 17219,69263,18974,18972,19687,67153 Mcm6,Rfc3,Pole2,Pold2,Rfc1,Rnaseh2b mmu03030 DNA replication 0.944643429437392 -0.0569477460394353 35 6 0.00272603362108133 2201 8063 69263,17219,18974,18972,19687,67153 Rfc3,Mcm6,Pole2,Pold2,Rfc1,Rnaseh2b mmu00071 Fatty acid degradation 0.946716280266493 -0.0547558291360733 49 9 0.00408905043162199 2201 8063 230639,52538,216739,110695,15107,94180,11669,12894,433256 Cyp4a29,Acaa2,Acsl6,Aldh7a1,Hadh,Acsbg1,Aldh2,Cpt1a,Acsl5 ko00071 Fatty acid degradation 0.946716280266493 -0.0547558291360733 49 9 0.00408905043162199 2201 8063 11669,94180,15107,110695,12894,433256,216739,230639,52538 Aldh2,Acsbg1,Hadh,Aldh7a1,Cpt1a,Acsl5,Acsl6,Cyp4a29,Acaa2 mmu05033 Nicotine addiction 0.947894825506248 -0.053511726440617 40 7 0.00318037255792821 2201 8063 242443,140919,14409,110886,12287,14799,14811 Grin3a,Slc17a6,Gabrr2,Gabra5,Cacna1b,Gria1,Grin2a ko05033 Nicotine addiction 0.947894825506248 -0.053511726440617 40 7 0.00318037255792821 2201 8063 242443,140919,110886,14409,14811,14799,12287 Grin3a,Slc17a6,Gabra5,Gabrr2,Grin2a,Gria1,Cacna1b mmu00531 Glycosaminoglycan degradation 0.95257538723143 -0.0485860284135516 21 3 0.00136301681054066 2201 8063 15211,15931,27029 Hexa,Ids,Sgsh ko00531 Glycosaminoglycan degradation 0.95257538723143 -0.0485860284135516 21 3 0.00136301681054066 2201 8063 15931,27029,15211 Ids,Sgsh,Hexa mmu_M00177 Ribosome, eukaryotes 0.954450696064263 -0.0466192913523831 98 20 0.00908677873693776 2201 8063 66475,56040,68436,68028,67115,114641,19946,11837,20088,19944,267019,57808,67025,14109,225215,19921,237433,100502825,20090,19981 Rps23,Rplp1,Rpl34,Rpl22l1,Rpl14,Rpl31,Rpl30,Rplp0,Rps24,Rpl29,Rps15a,Rpl35a,Rpl11,Fau,Rsl24d1,Rpl19,Gm4925,Rpl37rt,Rps29,Rpl37a M00177 Ribosome, eukaryotes 0.954450696064263 -0.0466192913523831 98 20 0.00908677873693776 2201 8063 20090,19981,14109,225215,19921,100502825,237433,57808,67025,267019,20088,19944,114641,19946,11837,68028,68436,67115,66475,56040 Rps29,Rpl37a,Fau,Rsl24d1,Rpl19,Rpl37rt,Gm4925,Rpl35a,Rpl11,Rps15a,Rps24,Rpl29,Rpl31,Rpl30,Rplp0,Rpl22l1,Rpl34,Rpl14,Rps23,Rplp1 mmu05012 Parkinson's disease 0.954573309989475 -0.0464908341669401 144 31 0.0140845070422535 2201 8063 11957,105675,67847,67184,18951,12864,22335,22213,50873,84682,57320,67128,68194,11739,11783,20463,28080,224129,68943,66052,66916,75406,110877,22333,17993,14677,22334,69875,20617,14678,66725 Atp5j,Ppif,Sncaip,Ndufa13,Sept5,Cox6c,Vdac3,Ube2g2,Prkn,Cox4i2,Park7,Ube2g1,Ndufb4,Slc25a4,Apaf1,Cox7a2l,Atp5o,Adcy5,Pink1,Sdhc,Ndufb7,Ndufs7,Slc18a1,Vdac1,Ndufs4,Gnai1,Vdac2,Ndufa11,Snca,Gnai2,Lrrk2 M00146 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 0.9574525537613 -0.0434791113626063 16 2 0.000908677873693776 2201 8063 67184,69875 Ndufa13,Ndufa11 mmu_M00146 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 0.9574525537613 -0.0434791113626063 16 2 0.000908677873693776 2201 8063 67184,69875 Ndufa13,Ndufa11 mmu04623 Cytosolic DNA-sensing pathway 0.958235672985109 -0.0426615260619321 64 12 0.00545206724216265 2201 8063 77125,56417,70428,67486,58203,18035,56489,78929,16150,20018,18033,15977 Il33,Adar,Polr3b,Polr3g,Zbp1,Nfkbia,Ikbke,Polr3h,Ikbkb,Polr1d,Nfkb1,Ifnb1 ko04623 Cytosolic DNA-sensing pathway 0.958235672985109 -0.0426615260619321 64 12 0.00545206724216265 2201 8063 15977,18033,20018,16150,78929,18035,56489,58203,70428,56417,67486,77125 Ifnb1,Nfkb1,Polr1d,Ikbkb,Polr3h,Nfkbia,Ikbke,Zbp1,Polr3b,Adar,Polr3g,Il33 M00693 Cell cycle - G2/M transition 0.958830023043656 -0.0420414637669138 10 1 0.000454338936846888 2201 8063 22390 Wee1 mmu_M00693 Cell cycle - G2/M transition 0.958830023043656 -0.0420414637669138 10 1 0.000454338936846888 2201 8063 22390 Wee1 ko00053 Ascorbate and aldarate metabolism 0.960866810056541 -0.0399194747715242 27 4 0.00181735574738755 2201 8063 22235,11669,394433,110695 Ugdh,Aldh2,Ugt1a5,Aldh7a1 mmu00053 Ascorbate and aldarate metabolism 0.960866810056541 -0.0399194747715242 27 4 0.00181735574738755 2201 8063 22235,11669,110695,394433 Ugdh,Aldh2,Aldh7a1,Ugt1a5 ko00983 Drug metabolism - other enzymes 0.961559574267989 -0.0391987561556294 51 9 0.00408905043162199 2201 8063 80914,72361,72269,394433,22245,22247,76654,103149,234673 Uck2,Ces2g,Cda,Ugt1a5,Uck1,Umps,Upp2,Upb1,Ces2e mmu00983 Drug metabolism - other enzymes 0.961559574267989 -0.0391987561556294 51 9 0.00408905043162199 2201 8063 234673,76654,103149,22245,22247,72361,72269,394433,80914 Ces2e,Upp2,Upb1,Uck1,Umps,Ces2g,Cda,Ugt1a5,Uck2 mmu_M00430 Exon junction complex (EJC) 0.962557039166362 -0.0381619531045444 22 3 0.00136301681054066 2201 8063 56488,66441,19704 Nxt1,Magohb,Upf1 M00430 Exon junction complex (EJC) 0.962557039166362 -0.0381619531045444 22 3 0.00136301681054066 2201 8063 56488,19704,66441 Nxt1,Upf1,Magohb ko04940 Type I diabetes mellitus 0.966809397001015 -0.0337539105051599 70 13 0.00590640617900954 2201 8063 16159,19276,14102,12876,16160,16333,14961,15893,12487,15000,14415,14999,16183 Il12a,Ptprn2,Fas,Cpe,Il12b,Ins1,H2-Ab1,Ica1,Cd28,H2-DMb2,Gad1,H2-DMb1,Il2 mmu04940 Type I diabetes mellitus 0.966809397001015 -0.0337539105051599 70 13 0.00590640617900954 2201 8063 16160,14961,16333,12876,14999,16183,12487,15893,14415,15000,16159,19276,14102 Il12b,H2-Ab1,Ins1,Cpe,H2-DMb1,Il2,Cd28,Ica1,Gad1,H2-DMb2,Il12a,Ptprn2,Fas mmu00450 Selenocompound metabolism 0.967428440901963 -0.0331138197056173 17 2 0.000908677873693776 2201 8063 23972,23971 Papss2,Papss1 M00158 F-type ATPase, eukaryotes 0.967428440901963 -0.0331138197056173 17 2 0.000908677873693776 2201 8063 11957,28080 Atp5j,Atp5o ko00450 Selenocompound metabolism 0.967428440901963 -0.0331138197056173 17 2 0.000908677873693776 2201 8063 23971,23972 Papss1,Papss2 mmu_M00158 F-type ATPase, eukaryotes 0.967428440901963 -0.0331138197056173 17 2 0.000908677873693776 2201 8063 11957,28080 Atp5j,Atp5o mmu00130 Ubiquinone and other terpenoid-quinone biosynthesis 0.970082366191189 -0.0303742974905007 11 1 0.000454338936846888 2201 8063 71883 Coq2 mmu00430 Taurine and hypotaurine metabolism 0.970082366191189 -0.0303742974905007 11 1 0.000454338936846888 2201 8063 14415 Gad1 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 0.970082366191189 -0.0303742974905007 11 1 0.000454338936846888 2201 8063 71883 Coq2 ko00430 Taurine and hypotaurine metabolism 0.970082366191189 -0.0303742974905007 11 1 0.000454338936846888 2201 8063 14415 Gad1 mmu_M00076 Dermatan sulfate degradation 0.970082366191189 -0.0303742974905007 11 1 0.000454338936846888 2201 8063 15931 Ids M00076 Dermatan sulfate degradation 0.970082366191189 -0.0303742974905007 11 1 0.000454338936846888 2201 8063 15931 Ids mmu_M00337 Immunoproteasome 0.975130973301619 -0.0251834854145665 18 2 0.000908677873693776 2201 8063 26440,26443 Psma1,Psma6 M00337 Immunoproteasome 0.975130973301619 -0.0251834854145665 18 2 0.000908677873693776 2201 8063 26440,26443 Psma1,Psma6 ko03040 Spliceosome 0.975635381302119 -0.0246663471006408 133 27 0.012267151294866 2201 8063 66373,20383,64340,66070,107686,78651,50783,71713,20639,15387,73666,15511,76522,68981,66441,68592,67465,217207,66642,14105,20643,71702,68183,67678,15481,229279,67439 Lsm5,Srsf3,Dhx38,Cwc15,Snrpd2,Lsm6,Lsm4,Cdc40,Snrpb2,Hnrnpk,Thoc3,Hspa1b,Lsm8,Snrpa1,Magohb,Syf2,Sf3a1,Dhx8,Ctnnbl1,Srsf10,Snrpe,Cdc5l,Bcas2,Lsm3,Hspa8,Hnrnpa3,Xab2 mmu03040 Spliceosome 0.975635381302119 -0.0246663471006408 133 27 0.012267151294866 2201 8063 14105,217207,66642,66441,76522,68981,67465,68592,67439,15481,229279,71702,20643,67678,68183,66070,107686,64340,78651,66373,20383,73666,15511,71713,50783,20639,15387 Srsf10,Dhx8,Ctnnbl1,Magohb,Lsm8,Snrpa1,Sf3a1,Syf2,Xab2,Hspa8,Hnrnpa3,Cdc5l,Snrpe,Lsm3,Bcas2,Cwc15,Snrpd2,Dhx38,Lsm6,Lsm5,Srsf3,Thoc3,Hspa1b,Cdc40,Lsm4,Snrpb2,Hnrnpk mmu03020 RNA polymerase 0.979911887394246 -0.0202926221819375 30 4 0.00181735574738755 2201 8063 78929,70428,67486,20018 Polr3h,Polr3b,Polr3g,Polr1d ko03020 RNA polymerase 0.979911887394246 -0.0202926221819375 30 4 0.00181735574738755 2201 8063 78929,20018,67486,70428 Polr3h,Polr1d,Polr3g,Polr3b mmu_M00427 Nuclear pore complex 0.982729135252148 -0.0174217458878446 41 6 0.00272603362108133 2201 8063 71805,20610,218210,19069,110379,227720 Nup93,Sumo3,Nup153,Nup88,Sec13,Nup214 M00427 Nuclear pore complex 0.982729135252148 -0.0174217458878446 41 6 0.00272603362108133 2201 8063 227720,110379,19069,218210,71805,20610 Nup214,Sec13,Nup88,Nup153,Nup93,Sumo3 ko03050 Proteasome 0.982834643020308 -0.0173143896479427 46 7 0.00318037255792821 2201 8063 66997,17463,103554,26443,26440,59029,20422 Psmd12,Psmd7,Psme4,Psma6,Psma1,Psmd14,Sem1 mmu03050 Proteasome 0.982834643020308 -0.0173143896479427 46 7 0.00318037255792821 2201 8063 59029,20422,26440,103554,17463,66997,26443 Psmd14,Sem1,Psma1,Psme4,Psmd7,Psmd12,Psma6 mmu_M00182 RNA polymerase I, eukaryotes 0.984203545775133 -0.0159225478589917 13 1 0.000454338936846888 2201 8063 20018 Polr1d M00182 RNA polymerase I, eukaryotes 0.984203545775133 -0.0159225478589917 13 1 0.000454338936846888 2201 8063 20018 Polr1d mmu03015 mRNA surveillance pathway 0.989939310196544 -0.0101116405643708 96 17 0.00772376192639709 2201 8063 67543,66441,216578,19704,235542,73699,226849,230721,56422,105083,26932,14852,434233,18458,56488,18789,18459 Pabpc6,Magohb,Papolg,Upf1,Ppp2r3a,Ppp2r1b,Ppp2r5a,Pabpc4,Hbs1l,Pelo,Ppp2r5e,Gspt1,Ppp1ccb,Pabpc1,Nxt1,Papola,Pabpc2 ko03015 mRNA surveillance pathway 0.989939310196544 -0.0101116405643708 96 17 0.00772376192639709 2201 8063 56422,105083,73699,226849,230721,434233,18458,56488,18789,18459,26932,14852,66441,67543,19704,235542,216578 Hbs1l,Pelo,Ppp2r1b,Ppp2r5a,Pabpc4,Ppp1ccb,Pabpc1,Nxt1,Papola,Pabpc2,Ppp2r5e,Gspt1,Magohb,Pabpc6,Upf1,Ppp2r3a,Papolg ko00190 Oxidative phosphorylation 0.992720025912992 -0.00730660241275124 134 25 0.0113584734211722 2201 8063 68194,11975,21871,74915,12864,67184,84682,11957,66290,140494,11964,69875,242341,70383,192113,76429,17993,67895,66916,75406,66052,20463,11973,11974,28080 Ndufb4,Atp6v0a1,Atp6v0a2,Atp6v1e2,Cox6c,Ndufa13,Cox4i2,Atp5j,Atp6v1g1,Atp6v0a4,Atp6v1a,Ndufa11,Atp6v0d2,Cox10,Atp12a,Lhpp,Ndufs4,Ppa1,Ndufb7,Ndufs7,Sdhc,Cox7a2l,Atp6v1e1,Atp6v0e,Atp5o mmu00190 Oxidative phosphorylation 0.992720025912992 -0.00730660241275124 134 25 0.0113584734211722 2201 8063 67895,66916,75406,66052,20463,11973,11974,28080,140494,11964,69875,242341,70383,192113,76429,17993,12864,74915,67184,84682,11957,66290,68194,21871,11975 Ppa1,Ndufb7,Ndufs7,Sdhc,Cox7a2l,Atp6v1e1,Atp6v0e,Atp5o,Atp6v0a4,Atp6v1a,Ndufa11,Atp6v0d2,Cox10,Atp12a,Lhpp,Ndufs4,Cox6c,Atp6v1e2,Ndufa13,Cox4i2,Atp5j,Atp6v1g1,Ndufb4,Atp6v0a2,Atp6v0a1 mmu00140 Steroid hormone biosynthesis 0.995380597281279 -0.00463010513134784 87 14 0.00636074511585643 2201 8063 56448,13078,13075,208665,94224,13074,13123,394433,56348,12846,13070,15487,105349,15484 Cyp2d22,Cyp1b1,Cyp19a1,Akr1d1,Srd5a2,Cyp17a1,Cyp7b1,Ugt1a5,Hsd17b12,Comt,Cyp11a1,Hsd17b3,Akr1c18,Hsd11b2 ko00140 Steroid hormone biosynthesis 0.995380597281279 -0.00463010513134784 87 14 0.00636074511585643 2201 8063 56448,208665,94224,13075,13078,15487,13070,12846,56348,15484,105349,13074,13123,394433 Cyp2d22,Akr1d1,Srd5a2,Cyp19a1,Cyp1b1,Hsd17b3,Cyp11a1,Comt,Hsd17b12,Hsd11b2,Akr1c18,Cyp17a1,Cyp7b1,Ugt1a5 mmu05416 Viral myocarditis 0.996102284553761 -0.00390533133524187 88 14 0.00636074511585643 2201 8063 12122,16415,16414,24052,14999,15000,230861,12389,12487,12443,14961,13690,19353,14360 Bid,Itgb2l,Itgb2,Sgcd,H2-DMb1,H2-DMb2,Eif4g3,Cav1,Cd28,Ccnd1,H2-Ab1,Eif4g2,Rac1,Fyn ko05330 Allograft rejection 0.996407407139165 -0.00359906172053318 64 9 0.00408905043162199 2201 8063 15000,12487,16183,14999,14961,16160,14102,16159,16153 H2-DMb2,Cd28,Il2,H2-DMb1,H2-Ab1,Il12b,Fas,Il12a,Il10 mmu05330 Allograft rejection 0.996407407139165 -0.00359906172053318 64 9 0.00408905043162199 2201 8063 16159,16153,14102,14961,16160,16183,14999,15000,12487 Il12a,Il10,Fas,H2-Ab1,Il12b,Il2,H2-DMb1,H2-DMb2,Cd28 ko03013 RNA transport 0.996955179062135 -0.00304946583612202 167 31 0.0140845070422535 2201 8063 71805,73666,56488,18459,237221,18458,68969,20610,230721,16211,218268,19069,21335,227720,13690,20430,53975,67204,100042807,110379,19704,66231,67543,230861,13664,218210,68135,67676,67724,66441,208366 Nup93,Thoc3,Nxt1,Pabpc2,Gemin8,Pabpc1,Eif1b,Sumo3,Pabpc4,Kpnb1,Eif4e1b,Nup88,Tacc3,Nup214,Eif4g2,Cyfip1,Ddx20,Eif2s2,Eif3j2,Sec13,Upf1,Thoc7,Pabpc6,Eif4g3,Eif1a,Nup153,Eif3h,Rpp21,Pop1,Magohb,Rpp40 mmu03013 RNA transport 0.996955179062135 -0.00304946583612202 167 31 0.0140845070422535 2201 8063 67724,66441,208366,68135,67676,218210,67543,230861,13664,110379,19704,66231,100042807,67204,53975,20430,13690,21335,227720,19069,16211,218268,230721,20610,68969,237221,18459,56488,18458,73666,71805 Pop1,Magohb,Rpp40,Eif3h,Rpp21,Nup153,Pabpc6,Eif4g3,Eif1a,Sec13,Upf1,Thoc7,Eif3j2,Eif2s2,Ddx20,Cyfip1,Eif4g2,Tacc3,Nup214,Nup88,Kpnb1,Eif4e1b,Pabpc4,Sumo3,Eif1b,Gemin8,Pabpc2,Nxt1,Pabpc1,Thoc3,Nup93 ko00970 Aminoacyl-tRNA biosynthesis 0.997583902348876 -0.0024190211249352 66 9 0.00408905043162199 2201 8063 105148,71807,107271,102436,107508,229487,244141,226414,110960 Iars,Tars2,Yars,Lars2,Eprs,Gatb,Nars2,Dars,Tars mmu00970 Aminoacyl-tRNA biosynthesis 0.997583902348876 -0.0024190211249352 66 9 0.00408905043162199 2201 8063 102436,107271,107508,105148,71807,110960,244141,229487,226414 Lars2,Yars,Eprs,Iars,Tars2,Tars,Nars2,Gatb,Dars mmu00860 Porphyrin and chlorophyll metabolism 0.998563807425071 -0.00143722488800394 41 4 0.00181735574738755 2201 8063 394433,12870,70383,107508 Ugt1a5,Cp,Cox10,Eprs ko00860 Porphyrin and chlorophyll metabolism 0.998563807425071 -0.00143722488800394 41 4 0.00181735574738755 2201 8063 394433,107508,70383,12870 Ugt1a5,Eprs,Cox10,Cp ko05340 Primary immunodeficiency 0.998948525011704 -0.00105202817593125 36 3 0.00136301681054066 2201 8063 16453,11628,54167 Jak3,Aicda,Icos mmu05340 Primary immunodeficiency 0.998948525011704 -0.00105202817593125 36 3 0.00136301681054066 2201 8063 11628,54167,16453 Aicda,Icos,Jak3 ko05168 Herpes simplex infection 0.998983592187718 -0.00101692470498102 215 40 0.0181735574738755 2201 8063 19294,16451,22034,11865,13000,14082,99730,22031,22030,68652,20383,20846,13666,15980,26419,16452,24088,18628,12702,21937,22059,16160,14961,15387,16150,434233,16159,27401,18033,16168,15977,14102,228980,16476,26409,15000,56489,22029,14999,18035 Nectin2,Jak1,Traf6,Arntl,Csnk2a2,Fadd,Taf13,Traf3,Traf2,Tab2,Srsf3,Stat1,Eif2ak3,Ifngr2,Mapk8,Jak2,Tlr2,Per3,Socs3,Tnfrsf1a,Trp53,Il12b,H2-Ab1,Hnrnpk,Ikbkb,Ppp1ccb,Il12a,Skp2,Nfkb1,Il15,Ifnb1,Fas,Taf4,Jun,Map3k7,H2-DMb2,Ikbke,Traf1,H2-DMb1,Nfkbia mmu05168 Herpes simplex infection 0.998983592187718 -0.00101692470498102 215 40 0.0181735574738755 2201 8063 18033,14102,15977,16476,228980,16168,15387,16150,16159,27401,434233,15000,14999,18035,22029,56489,26409,12702,24088,18628,21937,14961,16160,22059,14082,68652,22030,99730,22031,13000,26419,15980,16452,20846,20383,13666,16451,19294,11865,22034 Nfkb1,Fas,Ifnb1,Jun,Taf4,Il15,Hnrnpk,Ikbkb,Il12a,Skp2,Ppp1ccb,H2-DMb2,H2-DMb1,Nfkbia,Traf1,Ikbke,Map3k7,Socs3,Tlr2,Per3,Tnfrsf1a,H2-Ab1,Il12b,Trp53,Fadd,Tab2,Traf2,Taf13,Traf3,Csnk2a2,Mapk8,Ifngr2,Jak2,Stat1,Srsf3,Eif2ak3,Jak1,Nectin2,Arntl,Traf6 ko00980 Metabolism of xenobiotics by cytochrome P450 0.99899434447046 -0.00100616154033934 65 8 0.0036347114947751 2201 8063 12408,394433,54486,68214,211666,13078,12409,56847 Cbr1,Ugt1a5,Hpgds,Gsto2,Mgst2,Cyp1b1,Cbr2,Aldh1a3 mmu00980 Metabolism of xenobiotics by cytochrome P450 0.99899434447046 -0.00100616154033934 65 8 0.0036347114947751 2201 8063 12408,54486,394433,211666,68214,12409,56847,13078 Cbr1,Hpgds,Ugt1a5,Mgst2,Gsto2,Cbr2,Aldh1a3,Cyp1b1 ko05320 Autoimmune thyroid disease 0.999507541506459 -0.000492579791049193 79 10 0.00454338936846888 2201 8063 14961,12487,15000,14999,16183,22018,16153,12477,21819,14102 H2-Ab1,Cd28,H2-DMb2,H2-DMb1,Il2,Tpo,Il10,Ctla4,Tg,Fas mmu05320 Autoimmune thyroid disease 0.999507541506459 -0.000492579791049193 79 10 0.00454338936846888 2201 8063 14961,12487,15000,14999,16183,22018,16153,12477,21819,14102 H2-Ab1,Cd28,H2-DMb2,H2-DMb1,Il2,Tpo,Il10,Ctla4,Tg,Fas ko00830 Retinol metabolism 0.999814997225458 -0.000185019889666728 89 11 0.00499772830531577 2201 8063 235033,28200,213043,20148,19892,98711,394433,13082,232174,230639,63857 Rdh8,Dhrs4,Aox2,Dhrs3,Rpe65,Rdh10,Ugt1a5,Cyp26a1,Cyp26b1,Cyp4a29,Bco1 mmu00830 Retinol metabolism 0.999814997225458 -0.000185019889666728 89 11 0.00499772830531577 2201 8063 232174,230639,13082,63857,19892,394433,98711,213043,20148,235033,28200 Cyp26b1,Cyp4a29,Cyp26a1,Bco1,Rpe65,Ugt1a5,Rdh10,Aox2,Dhrs3,Rdh8,Dhrs4 ko05322 Systemic lupus erythematosus 0.99988363728763 -0.000116369483036 142 21 0.00954111767378464 2201 8063 12268,319177,16153,68231,51788,12279,14811,97122,15000,319161,14999,20823,109711,100042922,236663,15081,15078,14961,97114,26914,12487 C4b,Hist1h2ba,Il10,H2al2a,H2afz,C9,Grin2a,Hist2h4,H2-DMb2,Hist1h4n,H2-DMb1,Ssb,Actn1,H2al1a,H2al1j,H3f3b,H3f3a,H2-Ab1,Hist2h3c2,H2afy,Cd28 mmu05322 Systemic lupus erythematosus 0.99988363728763 -0.000116369483036 142 21 0.00954111767378464 2201 8063 51788,12268,68231,319177,16153,97122,15000,319161,14999,20823,12279,14811,236663,100042922,15081,109711,12487,26914,15078,97114,14961 H2afz,C4b,H2al2a,Hist1h2ba,Il10,Hist2h4,H2-DMb2,Hist1h4n,H2-DMb1,Ssb,C9,Grin2a,H2al1j,H2al1a,H3f3b,Actn1,Cd28,H2afy,H3f3a,Hist2h3c2,H2-Ab1 ko05332 Graft-versus-host disease 0.999926018663588 -7.39840731660322e-05 65 6 0.00272603362108133 2201 8063 12487,15000,14999,14102,16183,14961 Cd28,H2-DMb2,H2-DMb1,Fas,Il2,H2-Ab1 mmu05332 Graft-versus-host disease 0.999926018663588 -7.39840731660322e-05 65 6 0.00272603362108133 2201 8063 14999,16183,14102,12487,15000,14961 H2-DMb1,Il2,Fas,Cd28,H2-DMb2,H2-Ab1 mmu00982 Drug metabolism - cytochrome P450 0.999954832980851 -4.51680392097423e-05 67 6 0.00272603362108133 2201 8063 68214,213043,211666,394433,56847,54486 Gsto2,Aox2,Mgst2,Ugt1a5,Aldh1a3,Hpgds ko00982 Drug metabolism - cytochrome P450 0.999954832980851 -4.51680392097423e-05 67 6 0.00272603362108133 2201 8063 213043,68214,211666,394433,56847,54486 Aox2,Gsto2,Mgst2,Ugt1a5,Aldh1a3,Hpgds mmu04612 Antigen processing and presentation 0.999962661312387 -3.73393847189211e-05 91 10 0.00454338936846888 2201 8063 13039,15000,19141,13030,14999,14961,15511,15481,15525,15516 Ctsl,H2-DMb2,Lgmn,Ctsb,H2-DMb1,H2-Ab1,Hspa1b,Hspa8,Hspa4,Hsp90ab1 ko04612 Antigen processing and presentation 0.999962661312387 -3.73393847189211e-05 91 10 0.00454338936846888 2201 8063 15511,15481,15525,15516,14999,15000,13039,19141,13030,14961 Hspa1b,Hspa8,Hspa4,Hsp90ab1,H2-DMb1,H2-DMb2,Ctsl,Lgmn,Ctsb,H2-Ab1 ko03010 Ribosome 0.999981983521248 -1.80166410506306e-05 177 26 0.0118128123580191 2201 8063 267019,64659,57808,94062,67025,121022,225215,14109,237433,100502825,19921,64657,19981,20090,66845,66475,56040,68436,68028,67115,68537,114641,19946,11837,20088,19944 Rps15a,Mrps14,Rpl35a,Mrpl3,Rpl11,Mrps6,Rsl24d1,Fau,Gm4925,Rpl37rt,Rpl19,Mrps10,Rpl37a,Rps29,Mrpl33,Rps23,Rplp1,Rpl34,Rpl22l1,Rpl14,Mrpl13,Rpl31,Rpl30,Rplp0,Rps24,Rpl29 mmu03010 Ribosome 0.999981983521248 -1.80166410506306e-05 177 26 0.0118128123580191 2201 8063 19921,100502825,237433,14109,225215,20090,19981,64657,64659,267019,121022,67025,94062,57808,11837,19946,114641,68537,19944,20088,56040,66475,66845,67115,68028,68436 Rpl19,Rpl37rt,Gm4925,Fau,Rsl24d1,Rps29,Rpl37a,Mrps10,Mrps14,Rps15a,Mrps6,Rpl11,Mrpl3,Rpl35a,Rplp0,Rpl30,Rpl31,Mrpl13,Rpl29,Rps24,Rplp1,Rps23,Mrpl33,Rpl14,Rpl22l1,Rpl34 ko03008 Ribosome biogenesis in eukaryotes 0.999994119405732 -5.88061155918465e-06 116 13 0.00590640617900954 2201 8063 57815,213895,245474,14791,21453,73674,67724,208366,66711,216987,56488,13000,98956 Spata5,Bms1,Dkc1,Emg1,Tcof1,Wdr75,Pop1,Rpp40,Sbds,Utp6,Nxt1,Csnk2a2,Nat10 mmu03008 Ribosome biogenesis in eukaryotes 0.999994119405732 -5.88061155918465e-06 116 13 0.00590640617900954 2201 8063 57815,21453,14791,213895,245474,208366,67724,73674,66711,216987,56488,13000,98956 Spata5,Tcof1,Emg1,Bms1,Dkc1,Rpp40,Pop1,Wdr75,Sbds,Utp6,Nxt1,Csnk2a2,Nat10 mmu05204 Chemical carcinogenesis 0.999998498078472 -1.50192265636619e-06 93 8 0.0036347114947751 2201 8063 211666,68214,20887,56847,13078,12408,54486,394433 Mgst2,Gsto2,Sult1a1,Aldh1a3,Cyp1b1,Cbr1,Hpgds,Ugt1a5 ko05204 Chemical carcinogenesis 0.999998498078472 -1.50192265636619e-06 93 8 0.0036347114947751 2201 8063 68214,211666,13078,20887,56847,12408,394433,54486 Gsto2,Mgst2,Cyp1b1,Sult1a1,Aldh1a3,Cbr1,Ugt1a5,Hpgds ko04740 Olfactory transduction 0.999999999845001 -1.54999066606708e-10 1119 37 0.0168105406633348 2201 8063 19735,258426,258922,18574,258151,257951,258830,333329,104111,12323,14708,18573,14918,108058,258198,258502,259083,12314,258421,20541,258330,238384,258272,18322,19091,18346,19092,29845,259039,243634,18575,258153,258469,12313,258408,52589,110893 Rgs2,Olfr995,Olfr267,Pde1b,Olfr1505,Olfr987,Olfr103,Cngb1,Adcy3,Camk2b,Gng7,Pde1a,Gucy2d,Camk2d,Olfr224,Olfr279,Olfr547,Calm2,Olfr223,Slc8a1,Olfr1274-ps,Slc24a4,Olfr1402,Olfr24,Prkg1,Olfr47,Prkg2,Olfr155,Olfr1413,Ano2,Pde1c,Olfr412,Olfr90,Calm1,Olfr463,Ncald,Slc8a3 mmu04740 Olfactory transduction 0.999999999845001 -1.54999066606708e-10 1119 37 0.0168105406633348 2201 8063 110893,52589,12313,258408,258469,243634,18575,258153,29845,259039,18346,19092,18322,19091,258272,238384,258330,12314,20541,258421,259083,258502,108058,258198,14918,18573,14708,12323,104111,333329,257951,258830,258922,258151,18574,258426,19735 Slc8a3,Ncald,Calm1,Olfr463,Olfr90,Ano2,Pde1c,Olfr412,Olfr155,Olfr1413,Olfr47,Prkg2,Olfr24,Prkg1,Olfr1402,Slc24a4,Olfr1274-ps,Calm2,Slc8a1,Olfr223,Olfr547,Olfr279,Camk2d,Olfr224,Gucy2d,Pde1a,Gng7,Camk2b,Adcy3,Cngb1,Olfr987,Olfr103,Olfr267,Olfr1505,Pde1b,Olfr995,Rgs2