TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-MMU-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 0.903787092555604 -0.101161463412973 54 12 0.0047244094488189 2540 8688 15977,18035,22034,56489,52440,16150,74256,20203,16363,15289,18033,11820 Ifnb1,Nfkbia,Traf6,Ikbke,Tax1bp1,Ikbkb,Cyld,S100b,Irf2,Hmgb1,Nfkb1,App R-MMU-1475029 Reversible hydration of carbon dioxide 0.906215578575789 -0.0984780557957954 12 2 0.00078740157480315 2540 8688 76459,12352 Car12,Car5a R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.906215578575789 -0.0984780557957954 12 2 0.00078740157480315 2540 8688 11820,15199 App,Hebp1 R-MMU-1980148 Signaling by NOTCH3 0.906215578575789 -0.0984780557957954 12 2 0.00078740157480315 2540 8688 68318,16449 Aph1c,Jag1 R-MMU-202430 Translocation of ZAP-70 to Immunological synapse 0.906215578575789 -0.0984780557957954 12 2 0.00078740157480315 2540 8688 19260,14961 Ptpn22,H2-Ab1 R-MMU-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 0.907111740080774 -0.0974896390122117 34 7 0.00275590551181102 2540 8688 271970,14068,18550,19128,74008,330817,545260 Arsj,F7,Furin,Pros1,Arsg,Dhps,Arsi R-MMU-69231 Cyclin D associated events in G1 0.907111740080774 -0.0974896390122117 34 7 0.00275590551181102 2540 8688 73699,17420,27401,12443,13555,13557,12571 Ppp2r1b,Mnat1,Skp2,Ccnd1,E2f1,E2f3,Cdk6 R-MMU-69236 G1 Phase 0.907111740080774 -0.0974896390122117 34 7 0.00275590551181102 2540 8688 73699,17420,27401,12571,12443,13555,13557 Ppp2r1b,Mnat1,Skp2,Cdk6,Ccnd1,E2f1,E2f3 R-MMU-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.907111740080774 -0.0974896390122117 34 7 0.00275590551181102 2540 8688 67819,66967,19359,20338,14376,23802,192193 Derl1,Edem3,Rad23b,Sel1l,Ganab,Amfr,Edem1 R-MMU-2559580 Oxidative Stress Induced Senescence 0.910167868848651 -0.0941262252217185 78 18 0.00708661417322835 2540 8688 54383,22059,22166,17248,15078,319161,97114,26419,16476,26416,216850,12571,17164,26399,17246,97122,15081,12418 Phc2,Trp53,Txn1,Mdm4,H3f3a,Hist1h4n,Hist2h3c2,Mapk8,Jun,Mapk14,Kdm6b,Cdk6,Mapkapk2,Map2k6,Mdm2,Hist2h4,H3f3b,Cbx4 R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.910229524917204 -0.094058486090925 30 6 0.00236220472440945 2540 8688 66596,20018,78929,70428,98488,67486 Gtf3a,Polr1d,Polr3h,Polr3b,Gtf3c3,Polr3g R-MMU-390247 Beta-oxidation of very long chain fatty acids 0.911230377997464 -0.092959528952877 7 1 0.000393700787401575 2540 8688 170789 Acot8 R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.911230377997464 -0.092959528952877 7 1 0.000393700787401575 2540 8688 12447 Ccne1 R-MMU-111471 Apoptotic factor-mediated response 0.911230377997464 -0.092959528952877 7 1 0.000393700787401575 2540 8688 11783 Apaf1 R-MMU-189483 Heme degradation 0.911230377997464 -0.092959528952877 7 1 0.000393700787401575 2540 8688 394433 Ugt1a5 R-MMU-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.911230377997464 -0.092959528952877 7 1 0.000393700787401575 2540 8688 13197 Gadd45a R-MMU-1482883 Acyl chain remodeling of DAG and TAG 0.911230377997464 -0.092959528952877 7 1 0.000393700787401575 2540 8688 23945 Mgll R-MMU-196757 Metabolism of folate and pterines 0.912813424602352 -0.0912237734846272 17 3 0.00118110236220472 2540 8688 270685,17768,20509 Mthfd1l,Mthfd2,Slc19a1 R-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.912813424602352 -0.0912237734846272 17 3 0.00118110236220472 2540 8688 320635,15122,11826 Cyb5r2,Hba-a1,Aqp1 R-MMU-1480926 O2/CO2 exchange in erythrocytes 0.912813424602352 -0.0912237734846272 17 3 0.00118110236220472 2540 8688 320635,15122,11826 Cyb5r2,Hba-a1,Aqp1 R-MMU-157579 Telomere Maintenance 0.914900828531134 -0.0889396036995783 26 5 0.00196850393700787 2540 8688 19687,245474,69263,18974,18972 Rfc1,Dkc1,Rfc3,Pole2,Pold2 R-MMU-912694 Regulation of IFNA signaling 0.914900828531134 -0.0889396036995783 26 5 0.00196850393700787 2540 8688 20846,15977,16451,12703,19246 Stat1,Ifnb1,Jak1,Socs1,Ptpn1 R-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex 0.914900828531134 -0.0889396036995783 26 5 0.00196850393700787 2540 8688 76843,19687,69263,56438,18972 Dtl,Rfc1,Rfc3,Rbx1,Pold2 R-MMU-180786 Extension of Telomeres 0.914900828531134 -0.0889396036995783 26 5 0.00196850393700787 2540 8688 18974,18972,69263,245474,19687 Pole2,Pold2,Rfc3,Dkc1,Rfc1 R-MMU-3214842 HDMs demethylate histones 0.916883260629816 -0.0867751205769382 51 11 0.00433070866141732 2540 8688 97114,319161,76804,99982,97122,338523,67014,216850,193796,320595,104263 Hist2h3c2,Hist1h4n,Kdm4c,Kdm1a,Hist2h4,Kdm7a,Riox2,Kdm6b,Kdm4b,Phf8,Kdm3a R-MMU-5658442 Regulation of RAS by GAPs 0.917992140513137 -0.0855664499308266 67 15 0.00590551181102362 2540 8688 19414,66998,66997,218397,56438,18015,69601,114715,59029,103554,15461,54153,26440,17463,26443 Rasa3,Psmd5,Psmd12,Rasa1,Rbx1,Nf1,Dab2ip,Spred1,Psmd14,Psme4,Hras,Rasa4,Psma1,Psmd7,Psma6 R-MMU-6798695 Neutrophil degranulation 0.919035532094904 -0.0844304935056473 561 150 0.0590551181102362 2540 8688 18103,212032,14130,80910,12182,66681,20813,104112,227613,21938,11717,72269,14569,19330,11537,12331,15516,14667,18753,208795,13030,105722,66997,109620,56016,70495,20972,64138,70152,105245,16498,110173,53378,12306,22072,106572,11975,18600,235661,227753,212114,74244,544963,16004,70450,67963,12359,329547,74012,216134,269116,12283,14302,11689,16410,19261,70536,71902,18033,383295,17064,19276,11674,380839,13014,24088,20868,26364,26416,18772,20409,22596,12491,12505,210992,17463,117586,16790,17380,76763,78892,74287,18405,19204,21858,16970,11625,26458,13032,71517,435350,241633,15289,11758,13505,21968,353204,11846,50770,13036,16415,66713,66060,69116,71884,19349,11886,18641,19271,23912,66222,231507,72042,215449,107767,18805,14134,14319,69660,56444,59029,442827,11772,380924,16480,235567,19353,18793,75744,55950,11783,15926,72157,29875,100037283,16854,30960,16211,15481,68682,110078,20430,16414,100037258,18792,20716,19288,13367,15511,104009 Nme2,Hk3,Fcgr2b,Gpr84,Bst1,Pgm1,Srp14,Acly,Tubb4b,Tnfrsf1b,Ampd3,Cda,Gdi2,Rab18,Cfd,Cap1,Hsp90ab1,Gm2a,Prkcd,Tmem63a,Ctsb,Ano6,Psmd12,Dsp,Hebp2,Atp6ap2,Syngr1,Ctsz,Mettl7a1,Txndc5,Kcnab2,Manba,Sdcbp,Anxa2,Prss2,Rab31,Atp6v0a1,Padi2,Dync1li1,Gsn,Nhlrc3,Atg7,Iqgap2,Igf2r,Unc13d,Npc2,Cat,Bpi,Rap2b,Pdxk,Nfasc,Cab39,Frk,Alox5,Itgav,Sirpa,Qpct,Cand1,Nfkb1,Ypel5,Cd93,Ptprn2,Aldoa,Serpinb1c,Cstb,Tlr2,Stk10,Adgre5,Mapk14,Pkp1,Ostf1,Xrcc5,Cd36,Cd44,Lpcat1,Psmd7,A1bg,Anpep,Mme,Mospd2,Crispld2,Kcmf1,Orm1,Ptafr,Timp2,Lrmp,Ahsg,Slc27a2,Ctsc,Vps35l,Serpinb6e,Atp8b4,Hmgb1,Prdx6,Dsc1,Tom1,Aldoart1,Arg1,Atp11a,Ctsh,Itgb2l,Actr2,Cystm1,Ubr4,Chit1,Rab7,Asah1,Pfkl,Ptprj,Rhof,Serpinb1a,Plac8,Cotl1,Rap1b,Scamp1,Pld1,Fcnb,Fth1,Tmbim1,Actr10,Psmd14,Rab44,Ap2a2,Olfm4,Jup,Dnajc13,Rac1,Plaur,Svip,Bri3,Apaf1,Idh1,Pgm2,Iqgap1,Rnaset2a,Lgals3,Vapa,Kpnb1,Hspa8,Slc44a2,Pygb,Cyfip1,Itgb2,Dnajc3,Plau,Serpina3n,Ptx3,Diaph1,Hspa1b,Qsox1 R-MMU-1679131 Trafficking and processing of endosomal TLR 0.921759231790361 -0.0814712264145276 22 4 0.0015748031496063 2540 8688 218275,170743,19141,13030 BC051665,Tlr7,Lgmn,Ctsb R-MMU-5696394 DNA Damage Recognition in GG-NER 0.922398964608542 -0.0807774325251616 35 7 0.00275590551181102 2540 8688 11545,225280,108679,56505,56438,19359,227195 Parp1,Ino80c,Cops8,Ruvbl1,Rbx1,Rad23b,Ino80d R-MMU-5693532 DNA Double-Strand Break Repair 0.924146037930032 -0.0788851701211656 133 32 0.0125984251968504 2540 8688 22059,223970,54125,26419,56626,21975,70620,193796,22596,69263,19363,97122,16647,27223,107976,12144,12021,225182,18972,19687,17535,27015,14048,57434,319161,13870,14049,232314,11545,15574,74335,19356 Trp53,Rmi2,Polm,Mapk8,Poll,Top3a,Ube2v2,Kdm4b,Xrcc5,Rfc3,Rad51b,Hist2h4,Kpna2,Trp53bp1,Babam2,Blm,Bard1,Rbbp8,Pold2,Rfc1,Mre11a,Polk,Eya1,Xrcc2,Hist1h4n,Ercc1,Eya2,Ppp4r2,Parp1,Hus1,Xrcc3,Rad17 R-MMU-446203 Asparagine N-linked glycosylation 0.925145030470839 -0.0778047640617273 252 64 0.0251968503937008 2540 8688 11889,20334,16333,54342,56494,99412,21802,56336,20441,89867,20442,105522,13426,66967,20447,17156,20440,66789,20449,50798,230815,67857,77038,20450,109676,11735,98388,14376,67542,56395,22428,56358,20742,64138,107895,235661,26938,23956,192193,11890,14584,216131,20444,13191,21787,50935,72978,218138,20454,110379,242362,13032,67665,23802,53618,67819,29858,14799,69608,269181,19359,241230,74091,20338 Asgr1,Sec23a,Ins1,Gnpnat1,Gosr2,Golga2,Tgfa,B4galt5,St3gal3,Sec16b,St3gal1,Ankrd28,Dync1i1,Edem3,St6galnac3,Man1a2,St6gal1,Alg14,St8sia1,Gne,Man1c1,Ppp6c,Arfgap2,St8sia2,Ank2,Ank3,Chst10,Ganab,Cog6,Tmem115,Dctn6,Copz2,Sptbn1,Ctsz,Mgat5,Dync1li1,St6galnac5,Neu2,Edem1,Asgr2,Gfpt2,Trappc10,St3gal2,Dctn1,Tfg,St6galnac6,Cnih3,Gmds,St3gal5,Sec13,Manea,Ctsc,Dctn4,Amfr,Fut8,Derl1,Pmm1,Gria1,Sec24d,Mgat4a,Rad23b,St8sia6,Npl,Sel1l R-MMU-199977 ER to Golgi Anterograde Transport 0.925434382355288 -0.0774920491522221 118 28 0.0110236220472441 2540 8688 89867,109676,11735,21802,69608,14799,235661,13191,13426,216131,105522,110379,16333,72978,20334,56358,21787,22428,67542,56395,64138,99412,77038,20742,56494,67857,13032,67665 Sec16b,Ank2,Ank3,Tgfa,Sec24d,Gria1,Dync1li1,Dctn1,Dync1i1,Trappc10,Ankrd28,Sec13,Ins1,Cnih3,Sec23a,Copz2,Tfg,Dctn6,Cog6,Tmem115,Ctsz,Golga2,Arfgap2,Sptbn1,Gosr2,Ppp6c,Ctsc,Dctn4 R-MMU-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.925866493447842 -0.0770252302725375 31 6 0.00236220472440945 2540 8688 104625,13197,231464,20620,12447,72068 Cnot6,Gadd45a,Cnot6l,Plk2,Ccne1,Cnot2 R-MMU-5654726 Negative regulation of FGFR1 signaling 0.925866493447842 -0.0770252302725375 31 6 0.00236220472440945 2540 8688 24064,20779,14180,14173,16591,14182 Spry2,Src,Fgf9,Fgf2,Kl,Fgfr1 R-MMU-5654738 Signaling by FGFR2 0.92885867650526 -0.0737986760619482 72 16 0.0062992125984252 2540 8688 93686,80903,14173,18708,14183,18706,14388,59013,15461,18803,20779,24064,207920,20662,14172,14180 Rbfox2,Fgf16,Fgf2,Pik3r1,Fgfr2,Pik3ca,Gab1,Hnrnph1,Hras,Plcg1,Src,Spry2,Esrp1,Sos1,Fgf18,Fgf9 R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.929061362430554 -0.0735804902177239 13 2 0.00078740157480315 2540 8688 11826,15122 Aqp1,Hba-a1 R-MMU-5693571 Nonhomologous End-Joining (NHEJ) 0.929561682077642 -0.0730421135300451 48 10 0.00393700787401575 2540 8688 319161,12021,107976,56626,27223,97122,22596,54125,17535,70620 Hist1h4n,Bard1,Babam2,Poll,Trp53bp1,Hist2h4,Xrcc5,Polm,Mre11a,Ube2v2 R-MMU-2299718 Condensation of Prophase Chromosomes 0.930736468716179 -0.0717791043783098 27 5 0.00196850393700787 2540 8688 319161,244329,97122,320595,67956 Hist1h4n,Mcph1,Hist2h4,Phf8,Kmt5a R-MMU-5656169 Termination of translesion DNA synthesis 0.930736468716179 -0.0717791043783098 27 5 0.00196850393700787 2540 8688 18972,69263,216835,27015,19687 Pold2,Rfc3,Usp43,Polk,Rfc1 R-MMU-110320 Translesion Synthesis by POLH 0.931789589849562 -0.0706482517486033 18 3 0.00118110236220472 2540 8688 217365,69263,19687 Nploc4,Rfc3,Rfc1 R-MMU-174430 Telomere C-strand synthesis initiation 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 18974 Pole2 R-MMU-193144 Estrogen biosynthesis 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 13075 Cyp19a1 R-MMU-2514853 Condensation of Prometaphase Chromosomes 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 13000 Csnk2a2 R-MMU-166665 Terminal pathway of complement 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 12279 C9 R-MMU-5689877 Josephin domain DUBs 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 50873 Prkn R-MMU-68952 DNA replication initiation 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 18974 Pole2 R-MMU-72731 Recycling of eIF2:GDP 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 67204 Eif2s2 R-MMU-5652084 Fructose metabolism 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 20322 Sord R-MMU-210747 Regulation of gene expression in early pancreatic precursor cells 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 26424 Nr5a2 R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 20698 Sphk1 R-MMU-2393930 Phosphate bond hydrolysis by NUDT proteins 0.937203749731689 -0.0648545713623809 8 1 0.000393700787401575 2540 8688 213484 Nudt18 R-MMU-597592 Post-translational protein modification 0.937387187326573 -0.0646588618965517 826 223 0.0877952755905512 2540 8688 26443,107995,20742,71954,12021,67099,21951,330908,12006,227327,19244,56358,244682,50933,108153,18970,20444,268890,13191,20610,109359,107895,27392,17342,23956,71805,320311,320840,271970,17131,22193,235505,53869,66341,67665,13032,72433,23802,73582,74256,74996,29858,21973,218138,20454,242362,110379,231605,218476,241230,27401,327799,14799,22213,19326,230145,66313,67952,71974,56176,329777,269181,227195,19359,76509,59021,18035,12144,21812,108148,108150,66998,17126,78928,15481,17425,229595,231050,105522,107607,235497,54383,19211,89867,12314,94192,12042,19069,77038,78754,67196,59029,66568,20440,22030,20449,54624,50798,107260,22194,26409,18550,22214,20450,18793,13982,21825,15387,109676,19357,11735,225131,171212,22258,67561,233744,50873,107976,64138,67542,22428,56395,229603,67128,109978,30060,21838,192193,11890,11835,14584,14462,216131,103554,235661,26938,68501,23794,74008,17248,76800,11545,66510,17246,26440,15251,53618,17127,67819,17829,12182,21787,72978,50935,14068,235106,227720,71897,74091,271786,16319,16795,80294,20338,69608,56505,330817,22217,66997,21969,234700,22031,215494,22034,27223,54342,56494,99412,12418,11889,235441,20334,59040,16333,12313,20442,13426,17463,20447,66967,22059,237847,14537,21802,56336,19128,20441,226026,67857,230815,241062,93841,545260,100683,77739,53625,11647,17156,381694,109161,66789,232984,77125,98388,14376,56233,329908,218210,11650,69641,225280,68404,230801 Psma6,Cdc20,Sptbn1,Suds3,Bard1,Mettl21a,Tnks,Opcml,Axin2,B3gnt7,Ptp4a2,Copz2,Cntn5,Uchl3,Adamts7,Polb,St3gal2,Lsamp,Dctn1,Sumo3,Abraxas2,Mgat5,Pign,Mitf,Neu2,Nup93,Rnf152,Negr1,Arsj,Smad7,Ube2e3,Cd109,Rab11a,Eid3,Dctn4,Ctsc,Rab38,Amfr,Camkmt,Cyld,Usp47,Pmm1,Top2a,Gmds,St3gal5,Manea,Sec13,Galnt9,Gcnt4,St8sia6,Skp2,Usp44,Gria1,Ube2g2,Rab11b,Galnt12,Smurf2,Tomm20,Prmt3,Pigp,Pigk,Mgat4a,Ino80d,Rad23b,Plet1,Rab2a,Nfkbia,Blm,Tgfbr1,Galnt2,Galnt7,Psmd5,Smad2,Pigt,Hspa8,Foxk1,Adamtsl4,Galnt11,Ankrd28,Nod1,Leo1,Phc2,Pten,Sec16b,Calm2,C1galt1,Bcl10,Nup88,Arfgap2,Galnt15,Ube2t,Psmd14,Rwdd3,St6gal1,Traf2,St8sia1,Paf1,Gne,Otub1,Ube2e1,Map3k7,Furin,Ube2h,St8sia2,Plaur,Esr1,Thbs1,Hnrnpk,Ank2,Rad21,Ank3,Wac,Galnt10,Usp4,Wdr48,Spon1,Prkn,Babam2,Ctsz,Cog6,Dctn6,Tmem115,Otud7b,Ube2g1,Art4,Meltf,Thy1,Edem1,Asgr2,Ar,Gfpt2,Gata3,Trappc10,Psme4,Dync1li1,St6galnac5,Nsmce2,Adamts5,Arsg,Mdm4,Usp42,Parp1,Rnf181,Mdm2,Psma1,Hif1a,Fut8,Smad3,Derl1,Muc1,Bst1,Tfg,Cnih3,St6galnac6,F7,Ntm,Nup214,Lypd6b,Npl,Galnt13,Incenp,Large1,Pofut2,Sel1l,Sec24d,Ruvbl1,Dhps,Usp12,Psmd12,Top1,Nrn1l,Traf3,Pomgnt2,Traf6,Trp53bp1,Gnpnat1,Gosr2,Golga2,Cbx4,Asgr1,Usp3,Sec23a,Rhot1,Ins1,Calm1,St3gal1,Dync1i1,Psmd7,St6galnac3,Edem3,Trp53,Rtn4rl1,Gcnt1,Tgfa,B4galt5,Pros1,St3gal3,Smc5,Ppp6c,Man1c1,Pgap1,Uchl4,Arsi,Trrap,Adamtsl1,B3gnt2,Alpl,Man1a2,B3glct,Ube2q2,Alg14,B3gnt8,Il33,Chst10,Ganab,Hdac7,Usp24,Nup153,Alppl2,Wdr20,Ino80c,Nrn1,Pigv R-MMU-166208 mTORC1-mediated signalling 0.937505699645312 -0.0645324415343857 23 4 0.0015748031496063 2540 8688 19744,68576,66096,74370 Rheb,Lamtor5,Lamtor4,Rptor R-MMU-1170546 Prolactin receptor signaling 0.939053242766279 -0.062883099819814 32 6 0.00236220472440945 2540 8688 19116,14600,16452,12234,56438,19109 Prlr,Ghr,Jak2,Btrc,Rbx1,Prl R-MMU-73933 Resolution of Abasic Sites (AP sites) 0.939053242766279 -0.062883099819814 32 6 0.00236220472440945 2540 8688 11545,19687,18970,18294,69263,18972 Parp1,Rfc1,Polb,Ogg1,Rfc3,Pold2 R-MMU-380108 Chemokine receptors bind chemokines 0.939062724694264 -0.0628730025434487 53 11 0.00433070866141732 2540 8688 54199,20297,252837,12775,12767,12778,17329,12776,80901,20315,56066 Ccrl2,Ccl20,Ackr4,Ccr7,Cxcr4,Ackr3,Cxcl9,Ccr8,Cxcr6,Cxcl12,Cxcl11 R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.939062724694264 -0.0628730025434487 53 11 0.00433070866141732 2540 8688 71116,26951,16579,16569,77038,224630,16563,56358,16593,668303,16570 Stx18,Zw10,Kifap3,Kif3b,Arfgap2,Bnip1,Kif2a,Copz2,Klc1,Kif26a,Kif3c R-MMU-5696395 Formation of Incision Complex in GG-NER 0.943773692881293 -0.0578688736942483 41 8 0.0031496062992126 2540 8688 20610,13870,13871,11545,56438,19359,70620,17420 Sumo3,Ercc1,Ercc2,Parp1,Rbx1,Rad23b,Ube2v2,Mnat1 R-MMU-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.945891846236715 -0.0556270439114721 74 16 0.0062992125984252 2540 8688 69263,70620,108679,17420,18972,11545,19359,227195,56438,225280,27015,56505,19687,20610,13870,13871 Rfc3,Ube2v2,Cops8,Mnat1,Pold2,Parp1,Rad23b,Ino80d,Rbx1,Ino80c,Polk,Ruvbl1,Rfc1,Sumo3,Ercc1,Ercc2 R-MMU-622327 Postsynaptic nicotinic acetylcholine receptors 0.946570099051063 -0.0549102497428209 14 2 0.00078740157480315 2540 8688 108043,231252 Chrnb3,Chrna9 R-MMU-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.946570099051063 -0.0549102497428209 14 2 0.00078740157480315 2540 8688 17350,18972 Mlh1,Pold2 R-MMU-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 0.946570099051063 -0.0549102497428209 14 2 0.00078740157480315 2540 8688 14079,12389 Fabp2,Cav1 R-MMU-69298 Association of licensing factors with the pre-replicative complex 0.946570099051063 -0.0549102497428209 14 2 0.00078740157480315 2540 8688 13555,13557 E2f1,E2f3 R-MMU-181431 Acetylcholine Binding And Downstream Events 0.946570099051063 -0.0549102497428209 14 2 0.00078740157480315 2540 8688 231252,108043 Chrna9,Chrnb3 R-MMU-629602 Activation of Nicotinic Acetylcholine Receptors 0.946570099051063 -0.0549102497428209 14 2 0.00078740157480315 2540 8688 108043,231252 Chrnb3,Chrna9 R-MMU-4608870 Asymmetric localization of PCP proteins 0.947170848223192 -0.0542757921174042 58 12 0.0047244094488189 2540 8688 59029,66313,75788,66997,106042,66998,26443,22418,103554,17463,26440,93840 Psmd14,Smurf2,Smurf1,Psmd12,Prickle1,Psmd5,Psma6,Wnt5a,Psme4,Psmd7,Psma1,Vangl2 R-MMU-73728 RNA Polymerase I Promoter Opening 0.950106748545805 -0.0511809338099158 33 6 0.00236220472440945 2540 8688 17191,97114,319161,15081,97122,15078 Mbd2,Hist2h3c2,Hist1h4n,H3f3b,Hist2h4,H3f3a R-MMU-73884 Base Excision Repair 0.950106748545805 -0.0511809338099158 33 6 0.00236220472440945 2540 8688 18972,69263,18294,18970,11545,19687 Pold2,Rfc3,Ogg1,Polb,Parp1,Rfc1 R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly 0.950106748545805 -0.0511809338099158 33 6 0.00236220472440945 2540 8688 71805,227720,218210,217718,59126,19069 Nup93,Nup214,Nup153,Nek9,Nek6,Nup88 R-MMU-174417 Telomere C-strand (Lagging Strand) Synthesis 0.950314310911958 -0.0509624955159956 24 4 0.0015748031496063 2540 8688 69263,18974,18972,19687 Rfc3,Pole2,Pold2,Rfc1 R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 0.950314310911958 -0.0509624955159956 24 4 0.0015748031496063 2540 8688 93835,65969,22072,109129 Amn,Cubn,Prss2,Mmadhc R-MMU-69190 DNA strand elongation 0.950314310911958 -0.0509624955159956 24 4 0.0015748031496063 2540 8688 272551,18972,69263,19687 Gins2,Pold2,Rfc3,Rfc1 R-MMU-418594 G alpha (i) signalling events 0.950654861275626 -0.0506042042061803 209 51 0.0200787401574803 2540 8688 30878,12801,19065,17329,12374,20315,14678,239283,15552,20297,84112,18619,54393,242093,11820,56183,14767,15199,242425,212541,12061,140795,57254,13609,80901,12776,74191,65086,12062,216749,14702,15550,15557,12775,225192,18166,11542,13610,12778,67839,11553,56066,11551,14745,20608,109648,387347,11606,14677,12767,70839 Apln,Cnr1,Npy4r,Cxcl9,Casr,Cxcl12,Gnai2,Oxgr1,Htr1d,Ccl20,Sucnr1,Penk,Gabbr1,Rxfp4,App,Nmu,Nmur1,Hebp1,Gabbr2,Rho,Bdkrb1,P2ry14,Tas2r119,S1pr1,Cxcr6,Ccr8,P2ry13,Lpar3,Bdkrb2,Nmur2,Gng2,Htr1a,Htr1f,Ccr7,Hrh4,Npy1r,Adora3,S1pr3,Ackr3,Gpsm1,Adra2c,Cxcl11,Adra2a,Lpar1,Sstr4,Npy,Tas2r118,Agt,Gnai1,Cxcr4,P2ry12 R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.954734743065888 -0.0463217330346852 29 5 0.00196850393700787 2540 8688 67486,98488,70428,78929,20018 Polr3g,Gtf3c3,Polr3b,Polr3h,Polr1d R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome 0.95488770182785 -0.0461615351246765 59 12 0.0047244094488189 2540 8688 26440,12234,17463,14634,103554,26443,93687,66997,66998,56438,59029,56637 Psma1,Btrc,Psmd7,Gli3,Psme4,Psma6,Csnk1a1,Psmd12,Psmd5,Rbx1,Psmd14,Gsk3b R-MMU-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 15107 Hadh R-MMU-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 73699 Ppp2r1b R-MMU-391908 Prostanoid ligand receptors 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 19220 Ptgfr R-MMU-429947 Deadenylation of mRNA 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 72587 Pan3 R-MMU-110329 Cleavage of the damaged pyrimidine 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 18294 Ogg1 R-MMU-73928 Depyrimidination 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 18294 Ogg1 R-MMU-174403 Glutathione synthesis and recycling 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 68044 Chac2 R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 108043 Chrnb3 R-MMU-3270619 IRF3-mediated induction of type I IFN 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 207521 Dtx4 R-MMU-8850843 Phosphate bond hydrolysis by NTPDase proteins 0.955579610989558 -0.0454372001022265 9 1 0.000393700787401575 2540 8688 12497 Entpd6 R-MMU-74158 RNA Polymerase III Transcription 0.955870615348068 -0.045132714684036 38 7 0.00275590551181102 2540 8688 75627,66596,98488,67486,70428,78929,20018 Snapc1,Gtf3a,Gtf3c3,Polr3g,Polr3b,Polr3h,Polr1d R-MMU-76046 RNA Polymerase III Transcription Initiation 0.955870615348068 -0.045132714684036 38 7 0.00275590551181102 2540 8688 70428,67486,98488,20018,78929,75627,66596 Polr3b,Polr3g,Gtf3c3,Polr1d,Polr3h,Snapc1,Gtf3a R-MMU-5688426 Deubiquitination 0.957951987645279 -0.0429576195476919 237 58 0.0228346456692913 2540 8688 107260,22030,59029,17127,74996,15251,74256,26440,100683,17246,93841,22031,227195,66997,22217,225280,69641,13982,67952,56505,66313,329908,327799,27401,26409,77125,50933,59040,66998,17126,235441,229603,12006,107976,21812,21951,50873,12021,71954,18035,22034,67561,107995,26443,22258,17131,76800,19211,17248,22059,109359,107607,103554,17463,14462,11835,18970,17425 Otub1,Traf2,Psmd14,Smad3,Usp47,Hif1a,Cyld,Psma1,Trrap,Mdm2,Uchl4,Traf3,Ino80d,Psmd12,Usp12,Ino80c,Wdr20,Esr1,Tomm20,Ruvbl1,Smurf2,Usp24,Usp44,Skp2,Map3k7,Il33,Uchl3,Rhot1,Psmd5,Smad2,Usp3,Otud7b,Axin2,Babam2,Tgfbr1,Tnks,Prkn,Bard1,Suds3,Nfkbia,Traf6,Wdr48,Cdc20,Psma6,Usp4,Smad7,Usp42,Pten,Mdm4,Trp53,Abraxas2,Nod1,Psme4,Psmd7,Gata3,Ar,Polb,Foxk1 R-MMU-159418 Recycling of bile acids and salts 0.95882948730826 -0.0420420225057233 20 3 0.00118110236220472 2540 8688 20181,28254,27413 Rxra,Slco1a6,Abcb11 R-MMU-69186 Lagging Strand Synthesis 0.95882948730826 -0.0420420225057233 20 3 0.00118110236220472 2540 8688 19687,18972,69263 Rfc1,Pold2,Rfc3 R-MMU-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 0.959319964624971 -0.041530615715282 34 6 0.00236220472440945 2540 8688 27015,216835,19687,18972,217365,69263 Polk,Usp43,Rfc1,Pold2,Nploc4,Rfc3 R-MMU-6807878 COPI-mediated anterograde transport 0.959613064447865 -0.0412251336367172 72 15 0.00590551181102362 2540 8688 13426,77038,13191,99412,67665,20742,56494,109676,11735,16333,22428,56395,67542,235661,56358 Dync1i1,Arfgap2,Dctn1,Golga2,Dctn4,Sptbn1,Gosr2,Ank2,Ank3,Ins1,Dctn6,Tmem115,Cog6,Dync1li1,Copz2 R-MMU-1295596 Spry regulation of FGF signaling 0.95990855093778 -0.040917258497536 15 2 0.00078740157480315 2540 8688 20779,24064 Src,Spry2 R-MMU-194002 Glucocorticoid biosynthesis 0.95990855093778 -0.040917258497536 15 2 0.00078740157480315 2540 8688 13074,15484 Cyp17a1,Hsd11b2 R-MMU-5358508 Mismatch Repair 0.95990855093778 -0.040917258497536 15 2 0.00078740157480315 2540 8688 18972,17350 Pold2,Mlh1 R-MMU-110312 Translesion synthesis by REV1 0.95990855093778 -0.040917258497536 15 2 0.00078740157480315 2540 8688 69263,19687 Rfc3,Rfc1 R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.960739742386874 -0.040051726266702 64 13 0.00511811023622047 2540 8688 26440,112405,15251,17463,103554,26443,66997,66998,56438,29806,13819,112407,59029 Psma1,Egln1,Hif1a,Psmd7,Psme4,Psma6,Psmd12,Psmd5,Rbx1,Limd1,Epas1,Egln3,Psmd14 R-MMU-212300 PRC2 methylates histones and DNA 0.961082815796203 -0.0396946970378461 43 8 0.0031496062992126 2540 8688 97114,319161,15081,13435,11569,13433,15078,97122 Hist2h3c2,Hist1h4n,H3f3b,Dnmt3a,Aebp2,Dnmt1,H3f3a,Hist2h4 R-MMU-70153 Glucose transport 0.961082815796203 -0.0396946970378461 43 8 0.0031496062992126 2540 8688 19069,103988,212032,56636,227720,218210,15275,71805 Nup88,Gck,Hk3,Fgf21,Nup214,Nup153,Hk1,Nup93 R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.963635786698681 -0.0370418703894439 30 5 0.00196850393700787 2540 8688 218210,227720,71805,19069,103988 Nup153,Nup214,Nup93,Nup88,Gck R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.963635786698681 -0.0370418703894439 30 5 0.00196850393700787 2540 8688 20018,78929,70428,67486,75627 Polr1d,Polr3h,Polr3b,Polr3g,Snapc1 R-MMU-3108232 SUMO E3 ligases SUMOylate target proteins 0.964253185579598 -0.0364013782128703 93 20 0.0078740157480315 2540 8688 227720,16319,56233,20610,68501,17342,54383,218210,71805,21969,19357,15387,226026,11545,66341,27223,19069,12144,12418,21973 Nup214,Incenp,Hdac7,Sumo3,Nsmce2,Mitf,Phc2,Nup153,Nup93,Top1,Rad21,Hnrnpk,Smc5,Parp1,Eid3,Trp53bp1,Nup88,Blm,Cbx4,Top2a R-MMU-3371556 Cellular response to heat stress 0.965235872558229 -0.0353827799892101 73 15 0.00590551181102362 2540 8688 19069,15516,227720,108058,15511,70369,17164,15481,68196,74370,218210,56637,12323,71805,29810 Nup88,Hsp90ab1,Nup214,Camk2d,Hspa1b,Bag5,Mapkapk2,Hspa8,Hsbp1,Rptor,Nup153,Gsk3b,Camk2b,Nup93,Bag3 R-MMU-5693607 Processing of DNA double-strand break ends 0.965235872558229 -0.0353827799892101 73 15 0.00590551181102362 2540 8688 69263,223970,21975,70620,17535,107976,12021,225182,12144,319161,19356,97122,15574,27223,232314 Rfc3,Rmi2,Top3a,Ube2v2,Mre11a,Babam2,Bard1,Rbbp8,Blm,Hist1h4n,Rad17,Hist2h4,Hus1,Trp53bp1,Ppp4r2 R-MMU-1592389 Activation of Matrix Metalloproteinases 0.965736547695337 -0.0348642069188989 48 9 0.00354330708661417 2540 8688 21858,17384,22072,13039,18550,17386,17389,17387,17393 Timp2,Mmp10,Prss2,Ctsl,Furin,Mmp13,Mmp16,Mmp14,Mmp7 R-MMU-189200 Hexose transport 0.965736547695337 -0.0348642069188989 48 9 0.00354330708661417 2540 8688 71805,109342,218210,15275,103988,212032,56636,19069,227720 Nup93,Slc5a10,Nup153,Hk1,Gck,Hk3,Fgf21,Nup88,Nup214 R-MMU-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 0.965788419693331 -0.0348104959921631 69 14 0.00551181102362205 2540 8688 26440,112405,15251,17463,103554,26443,17684,66998,66997,29806,56438,112407,13819,59029 Psma1,Egln1,Hif1a,Psmd7,Psme4,Psma6,Cited2,Psmd5,Psmd12,Limd1,Rbx1,Egln3,Epas1,Psmd14 R-MMU-2262749 Cellular response to hypoxia 0.965788419693331 -0.0348104959921631 69 14 0.00551181102362205 2540 8688 56438,29806,66998,66997,13819,112407,59029,15251,17463,26440,112405,103554,26443,17684 Rbx1,Limd1,Psmd5,Psmd12,Epas1,Egln3,Psmd14,Hif1a,Psmd7,Psma1,Egln1,Psme4,Psma6,Cited2 R-MMU-4615885 SUMOylation of DNA replication proteins 0.967793769337211 -0.0327362626089133 44 8 0.0031496062992126 2540 8688 21969,218210,21973,71805,19069,16319,20610,227720 Top1,Nup153,Top2a,Nup93,Nup88,Incenp,Sumo3,Nup214 R-MMU-73893 DNA Damage Bypass 0.967793769337211 -0.0327362626089133 44 8 0.0031496062992126 2540 8688 18972,76843,216835,69263,217365,56438,19687,27015 Pold2,Dtl,Usp43,Rfc3,Nploc4,Rbx1,Rfc1,Polk R-MMU-5610780 Degradation of GLI1 by the proteasome 0.968509751378518 -0.0319967276483257 57 11 0.00433070866141732 2540 8688 66997,66998,56438,59029,18222,26440,17463,12234,103554,26443,14632 Psmd12,Psmd5,Rbx1,Psmd14,Numb,Psma1,Psmd7,Btrc,Psme4,Psma6,Gli1 R-MMU-174437 Removal of the Flap Intermediate from the C-strand 0.968579701807841 -0.0319245054499777 10 1 0.000393700787401575 2540 8688 18972 Pold2 R-MMU-110357 Displacement of DNA glycosylase by APEX1 0.968579701807841 -0.0319245054499777 10 1 0.000393700787401575 2540 8688 18294 Ogg1 R-MMU-8854691 Interleukin-19, 20, 22, 24 0.968579701807841 -0.0319245054499777 10 1 0.000393700787401575 2540 8688 213208 Il20rb R-MMU-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.968579701807841 -0.0319245054499777 10 1 0.000393700787401575 2540 8688 18972 Pold2 R-MMU-381038 XBP1(S) activates chaperone genes 0.968579701807841 -0.0319245054499777 10 1 0.000393700787401575 2540 8688 66212 Sec61b R-MMU-1834941 STING mediated induction of host immune responses 0.968579701807841 -0.0319245054499777 10 1 0.000393700787401575 2540 8688 207521 Dtx4 R-MMU-1538133 G0 and Early G1 0.968989280971586 -0.0315017291013825 26 4 0.0015748031496063 2540 8688 21973,13555,12447,13548 Top2a,E2f1,Ccne1,Dyrk1a R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.969862025351279 -0.0306014595079454 53 10 0.00393700787401575 2540 8688 66997,15507,66998,15511,15481,59029,17463,26440,103554,26443 Psmd12,Hspb1,Psmd5,Hspa1b,Hspa8,Psmd14,Psmd7,Psma1,Psme4,Psma6 R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA 0.970017683023438 -0.0304409777298015 16 2 0.00078740157480315 2540 8688 207521,69807 Dtx4,Trim32 R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle 0.970017683023438 -0.0304409777298015 16 2 0.00078740157480315 2540 8688 233977,207777 Ppfia1,Tspoap1 R-MMU-69205 G1/S-Specific Transcription 0.970017683023438 -0.0304409777298015 16 2 0.00078740157480315 2540 8688 13555,12447 E2f1,Ccne1 R-MMU-5656121 Translesion synthesis by POLI 0.970017683023438 -0.0304409777298015 16 2 0.00078740157480315 2540 8688 19687,69263 Rfc1,Rfc3 R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle 0.970017683023438 -0.0304409777298015 16 2 0.00078740157480315 2540 8688 207777,233977 Tspoap1,Ppfia1 R-MMU-389948 PD-1 signaling 0.970017683023438 -0.0304409777298015 16 2 0.00078740157480315 2540 8688 18566,14961 Pdcd1,H2-Ab1 R-MMU-983169 Class I MHC mediated antigen processing & presentation 0.9716041193779 -0.0288068420752317 215 51 0.0200787401574803 2540 8688 74646,19820,22019,26443,231670,16419,19155,50754,50764,67731,226098,269514,66998,20334,380928,75234,74165,12491,67845,103554,17969,30945,17463,17970,387524,74244,24105,240028,50760,20437,224826,26440,12234,207215,101358,59029,320118,110379,218215,16410,244421,27401,104184,81018,69608,66313,448987,69754,66997,56438,103583 Spsb1,Rlim,Tpp2,Psma6,Fbxo21,Itgb5,Npepps,Fbxw7,Fbxo15,Fbxo32,Hectd2,Fbxl4,Psmd5,Sec23a,Lmo7,Rnf19b,Fbxl22,Cd36,Rnf115,Psme4,Ncf1,Rnf19a,Psmd7,Ncf2,Znrf2,Atg7,Rbck1,Lnpep,Fbxo17,Siah1a,Ubr2,Psma1,Btrc,Fbxo40,Fbxl14,Psmd14,Fbxl13,Sec13,Rnf144b,Itgav,Lonrf1,Skp2,Blmh,Rnf114,Sec24d,Smurf2,Fbxl7,Fbxo7,Psmd12,Rbx1,Fbxw11 R-MMU-2990846 SUMOylation 0.972747434602174 -0.027630804384201 99 21 0.00826771653543307 2540 8688 227720,20610,56233,16319,71805,218210,54383,17342,68501,19357,15387,21969,27223,226026,66341,11545,12418,12144,19069,21973,66568 Nup214,Sumo3,Hdac7,Incenp,Nup93,Nup153,Phc2,Mitf,Nsmce2,Rad21,Hnrnpk,Top1,Trp53bp1,Smc5,Eid3,Parp1,Cbx4,Blm,Nup88,Top2a,Rwdd3 R-MMU-2559583 Cellular Senescence 0.974118644505389 -0.0262221711508573 139 31 0.0122047244094488 2540 8688 97114,319161,26419,23871,15078,13875,18033,12447,23872,22166,17535,22059,54383,17248,15901,20112,15081,12418,16906,15364,56317,97122,26399,17246,216850,12571,22194,17164,20111,26416,16476 Hist2h3c2,Hist1h4n,Mapk8,Ets1,H3f3a,Erf,Nfkb1,Ccne1,Ets2,Txn1,Mre11a,Trp53,Phc2,Mdm4,Id1,Rps6ka2,H3f3b,Cbx4,Lmnb1,Hmga2,Anapc7,Hist2h4,Map2k6,Mdm2,Kdm6b,Cdk6,Ube2e1,Mapkapk2,Rps6ka1,Mapk14,Jun R-MMU-69541 Stabilization of p53 0.974810957562259 -0.0255117164630579 54 10 0.00393700787401575 2540 8688 66998,66997,59029,22059,17248,17463,26440,103554,26443,17246 Psmd5,Psmd12,Psmd14,Trp53,Mdm4,Psmd7,Psma1,Psme4,Psma6,Mdm2 R-MMU-4641257 Degradation of AXIN 0.974810957562259 -0.0255117164630579 54 10 0.00393700787401575 2540 8688 59029,66313,66998,66997,26443,17463,21951,26440,12006,103554 Psmd14,Smurf2,Psmd5,Psmd12,Psma6,Psmd7,Tnks,Psma1,Axin2,Psme4 R-MMU-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.975546732911329 -0.0247572134428499 22 3 0.00118110236220472 2540 8688 22194,107995,56317 Ube2e1,Cdc20,Anapc7 R-MMU-69273 Cyclin A/B1 associated events during G2/M transition 0.975546732911329 -0.0247572134428499 22 3 0.00118110236220472 2540 8688 17420,22390,73699 Mnat1,Wee1,Ppp2r1b R-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.975546732911329 -0.0247572134428499 22 3 0.00118110236220472 2540 8688 52538,15107,110821 Acaa2,Hadh,Pcca R-MMU-975298 Ligand-gated ion channel transport 0.975546732911329 -0.0247572134428499 22 3 0.00118110236220472 2540 8688 14658,14409,110886 Glrb,Gabrr2,Gabra5 R-MMU-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.976171227483983 -0.0241172699606061 104 22 0.00866141732283465 2540 8688 232314,19363,97122,15574,27223,107976,74335,19356,12021,12144,225182,18972,21975,70620,69263,57434,319161,13870,19687,17535,27015,223970 Ppp4r2,Rad51b,Hist2h4,Hus1,Trp53bp1,Babam2,Xrcc3,Rad17,Bard1,Blm,Rbbp8,Pold2,Top3a,Ube2v2,Rfc3,Xrcc2,Hist1h4n,Ercc1,Rfc1,Mre11a,Polk,Rmi2 R-MMU-5423646 Aflatoxin activation and detoxification 0.977644917484744 -0.0226087449297095 17 2 0.00078740157480315 2540 8688 211666,71670 Mgst2,Acy3 R-MMU-174414 Processive synthesis on the C-strand of the telomere 0.977776239877114 -0.0224744287062475 11 1 0.000393700787401575 2540 8688 18972 Pold2 R-MMU-375281 Hormone ligand-binding receptors 0.977776239877114 -0.0224744287062475 11 1 0.000393700787401575 2540 8688 217674 Gphb5 R-MMU-189451 Heme biosynthesis 0.977776239877114 -0.0224744287062475 11 1 0.000393700787401575 2540 8688 70383 Cox10 R-MMU-73929 Base-Excision Repair, AP Site Formation 0.977776239877114 -0.0224744287062475 11 1 0.000393700787401575 2540 8688 18294 Ogg1 R-MMU-2142753 Arachidonic acid metabolism 0.978792048901886 -0.0214360707589503 72 14 0.00551181102362205 2540 8688 18979,19223,13078,18783,17164,11690,54486,19224,11689,12408,13109,11684,230639,21391 Pon1,Ptgis,Cyp1b1,Pla2g4a,Mapkapk2,Alox5ap,Hpgds,Ptgs1,Alox5,Cbr1,Cyp2j5,Alox12,Cyp4a29,Tbxas1 R-MMU-68882 Mitotic Anaphase 0.979068938953957 -0.0211532212046309 172 39 0.0153543307086614 2540 8688 70315,17463,434233,103554,26951,56430,76707,83431,16905,226849,67629,244495,73699,26932,107995,26443,66998,12237,208628,18472,76499,16319,66977,19357,66997,72415,108000,226747,100710,26440,56150,22367,17120,56317,110379,22194,59029,12617,16563 Hdac8,Psmd7,Ppp1ccb,Psme4,Zw10,Clip1,Clasp1,Ndel1,Lmna,Ppp2r5a,Spc24,Sgo2b,Ppp2r1b,Ppp2r5e,Cdc20,Psma6,Psmd5,Bub3,Kntc1,Pafah1b1,Clasp2,Incenp,Nuf2,Rad21,Psmd12,Sgo1,Cenpf,Ahctf1,Pds5b,Psma1,Mad2l1,Vrk1,Mad1l1,Anapc7,Sec13,Ube2e1,Psmd14,Cenpc1,Kif2a R-MMU-5693538 Homology Directed Repair 0.97914937135271 -0.0210710726531901 109 23 0.00905511811023622 2540 8688 70620,21975,69263,232314,11545,19363,97122,27223,15574,107976,74335,19356,225182,12144,12021,18972,19687,17535,27015,223970,57434,319161,13870 Ube2v2,Top3a,Rfc3,Ppp4r2,Parp1,Rad51b,Hist2h4,Trp53bp1,Hus1,Babam2,Xrcc3,Rad17,Rbbp8,Blm,Bard1,Pold2,Rfc1,Mre11a,Polk,Rmi2,Xrcc2,Hist1h4n,Ercc1 R-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane 0.980071002568308 -0.0201302583416956 89 18 0.00708661417322835 2540 8688 20088,14109,20090,217337,66475,27058,19921,20813,57808,19946,68436,56040,67115,11837,19981,267019,19944,100502825 Rps24,Fau,Rps29,Srp68,Rps23,Srp9,Rpl19,Srp14,Rpl35a,Rpl30,Rpl34,Rplp1,Rpl14,Rplp0,Rpl37a,Rps15a,Rpl29,Rpl37rt R-MMU-75815 Ubiquitin-dependent degradation of Cyclin D 0.980447315159454 -0.0197463674161535 51 9 0.00354330708661417 2540 8688 12443,66997,66998,56637,59029,103554,17463,26440,26443 Ccnd1,Psmd12,Psmd5,Gsk3b,Psmd14,Psme4,Psmd7,Psma1,Psma6 R-MMU-350562 Regulation of ornithine decarboxylase (ODC) 0.980447315159454 -0.0197463674161535 51 9 0.00354330708661417 2540 8688 66997,66998,18247,59029,17463,26440,103554,26443,18263 Psmd12,Psmd5,Oaz2,Psmd14,Psmd7,Psma1,Psme4,Psma6,Odc1 R-MMU-69229 Ubiquitin-dependent degradation of Cyclin D1 0.980447315159454 -0.0197463674161535 51 9 0.00354330708661417 2540 8688 12443,66997,66998,56637,59029,103554,17463,26440,26443 Ccnd1,Psmd12,Psmd5,Gsk3b,Psmd14,Psme4,Psmd7,Psma1,Psma6 R-MMU-2555396 Mitotic Metaphase and Anaphase 0.981278392791635 -0.0188990749750831 173 39 0.0153543307086614 2540 8688 16905,83431,226849,70315,17463,103554,434233,56430,26951,76707,12237,66998,208628,18472,244495,67629,107995,26932,26443,73699,66997,19357,108000,72415,226747,76499,16319,66977,22194,110379,59029,16563,12617,26440,100710,56150,22367,17120,56317 Lmna,Ndel1,Ppp2r5a,Hdac8,Psmd7,Psme4,Ppp1ccb,Clip1,Zw10,Clasp1,Bub3,Psmd5,Kntc1,Pafah1b1,Sgo2b,Spc24,Cdc20,Ppp2r5e,Psma6,Ppp2r1b,Psmd12,Rad21,Cenpf,Sgo1,Ahctf1,Clasp2,Incenp,Nuf2,Ube2e1,Sec13,Psmd14,Kif2a,Cenpc1,Psma1,Pds5b,Mad2l1,Vrk1,Mad1l1,Anapc7 R-MMU-3108214 SUMOylation of DNA damage response and repair proteins 0.982008768704865 -0.0181550412328485 73 14 0.00551181102362205 2540 8688 227720,11545,66341,226026,56233,20610,12418,19069,12144,71805,68501,54383,218210,19357 Nup214,Parp1,Eid3,Smc5,Hdac7,Sumo3,Cbx4,Nup88,Blm,Nup93,Nsmce2,Phc2,Nup153,Rad21 R-MMU-2467813 Separation of Sister Chromatids 0.982897487836857 -0.0172504492813141 166 37 0.0145669291338583 2540 8688 226849,83431,56430,26951,76707,70315,17463,103554,434233,18472,66998,12237,208628,107995,26443,26932,73699,244495,67629,108000,72415,226747,19357,66997,66977,16319,76499,59029,16563,12617,22194,110379,56317,17120,26440,100710,56150 Ppp2r5a,Ndel1,Clip1,Zw10,Clasp1,Hdac8,Psmd7,Psme4,Ppp1ccb,Pafah1b1,Psmd5,Bub3,Kntc1,Cdc20,Psma6,Ppp2r5e,Ppp2r1b,Sgo2b,Spc24,Cenpf,Sgo1,Ahctf1,Rad21,Psmd12,Nuf2,Incenp,Clasp2,Psmd14,Kif2a,Cenpc1,Ube2e1,Sec13,Anapc7,Mad1l1,Psma1,Pds5b,Mad2l1 R-MMU-68886 M Phase 0.983150937157031 -0.0169926231582584 247 58 0.0228346456692913 2540 8688 71175,71805,226849,83431,16905,76707,26951,56430,18750,434233,103554,17463,70315,244329,18472,67956,208628,12237,66998,97122,73699,59021,26443,26932,107995,67629,67121,99412,244495,226747,72415,218210,108000,59126,19357,66997,66977,227720,76499,16319,319161,12617,13000,16563,59029,320595,110379,22194,17120,56317,217718,22367,14245,56150,100710,19069,18751,26440 Nipbl,Nup93,Ppp2r5a,Ndel1,Lmna,Clasp1,Zw10,Clip1,Prkca,Ppp1ccb,Psme4,Psmd7,Hdac8,Mcph1,Pafah1b1,Kmt5a,Kntc1,Bub3,Psmd5,Hist2h4,Ppp2r1b,Rab2a,Psma6,Ppp2r5e,Cdc20,Spc24,Mastl,Golga2,Sgo2b,Ahctf1,Sgo1,Nup153,Cenpf,Nek6,Rad21,Psmd12,Nuf2,Nup214,Clasp2,Incenp,Hist1h4n,Cenpc1,Csnk2a2,Kif2a,Psmd14,Phf8,Sec13,Ube2e1,Mad1l1,Anapc7,Nek9,Vrk1,Lpin1,Mad2l1,Pds5b,Nup88,Prkcb,Psma1 R-MMU-163210 Formation of ATP by chemiosmotic coupling 0.983376833428334 -0.0167628819100795 18 2 0.00078740157480315 2540 8688 11957,28080 Atp5j,Atp5o R-MMU-189445 Metabolism of porphyrins 0.983376833428334 -0.0167628819100795 18 2 0.00078740157480315 2540 8688 70383,394433 Cox10,Ugt1a5 R-MMU-5674135 MAP2K and MAPK activation 0.983376833428334 -0.0167628819100795 18 2 0.00078740157480315 2540 8688 15461,110157 Hras,Raf1 R-MMU-622323 Presynaptic nicotinic acetylcholine receptors 0.984281754569602 -0.0158430869714792 12 1 0.000393700787401575 2540 8688 108043 Chrnb3 R-MMU-71384 Ethanol oxidation 0.984281754569602 -0.0158430869714792 12 1 0.000393700787401575 2540 8688 11669 Aldh2 R-MMU-211897 Cytochrome P450 - arranged by substrate type 0.984717533948168 -0.0154004465010407 99 20 0.0078740157480315 2540 8688 13074,20181,13075,18984,19223,13078,13082,230639,13070,13109,56448,14148,56050,11864,14149,232174,320997,21391,11622,13123 Cyp17a1,Rxra,Cyp19a1,Por,Ptgis,Cyp1b1,Cyp26a1,Cyp4a29,Cyp11a1,Cyp2j5,Cyp2d22,Fdx1,Cyp39a1,Arnt2,Fdxr,Cyp26b1,Cyp4f39,Tbxas1,Ahr,Cyp7b1 R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.985374484963548 -0.0147335222828576 48 8 0.0031496062992126 2540 8688 20090,68135,20088,267019,14109,100042807,67204,66475 Rps29,Eif3h,Rps24,Rps15a,Fau,Eif3j2,Eif2s2,Rps23 R-MMU-113418 Formation of the Early Elongation Complex 0.985397445483156 -0.0147102212410126 34 5 0.00196850393700787 2540 8688 13871,24116,67655,17420,20924 Ercc2,Nelfa,Ctdp1,Mnat1,Supt5 R-MMU-3214841 PKMTs methylate histone lysines 0.98545103396878 -0.014655840109033 70 13 0.00511811023622047 2540 8688 70673,18033,14013,67956,226830,11569,225888,69726,319161,214162,97114,97122,208266 Prdm16,Nfkb1,Mecom,Kmt5a,Smyd2,Aebp2,Kmt5b,Smyd3,Hist1h4n,Kmt2a,Hist2h3c2,Hist2h4,Dot1l R-MMU-3371453 Regulation of HSF1-mediated heat shock response 0.98554731596293 -0.0145581414029629 57 10 0.00393700787401575 2540 8688 19069,227720,15511,70369,15481,17164,218210,56637,71805,29810 Nup88,Nup214,Hspa1b,Bag5,Hspa8,Mapkapk2,Nup153,Gsk3b,Nup93,Bag3 R-MMU-69202 Cyclin E associated events during G1/S transition 0.986219429564177 -0.013876403942077 66 12 0.0047244094488189 2540 8688 66998,12447,66997,12443,11651,17420,59029,26440,17463,27401,26443,22390 Psmd5,Ccne1,Psmd12,Ccnd1,Akt1,Mnat1,Psmd14,Psma1,Psmd7,Skp2,Psma6,Wee1 R-MMU-674695 RNA Polymerase II Pre-transcription Events 0.986586662420225 -0.013504109004645 79 15 0.00590551181102362 2540 8688 17420,20924,70122,68776,67655,54624,74197,72949,228980,13871,24116,235497,13716,99730,83602 Mnat1,Supt5,Mllt3,Taf11,Ctdp1,Paf1,Gtf2e1,Ccnt2,Taf4,Ercc2,Nelfa,Leo1,Ell,Taf13,Gtf2a1 R-MMU-5334727 Mus musculus biological processes 0.986798106341635 -0.0132898133177968 238 55 0.0216535433070866 2540 8688 16452,21975,11865,19883,28077,14815,16906,68975,97122,15081,12144,13654,51788,94112,12952,327987,59027,17979,16905,20018,13433,384783,230753,223697,12702,97114,64009,79362,69790,13170,27373,16600,16367,20181,12953,14068,26914,319177,67381,76199,17350,12234,20787,18143,20602,264064,20850,19017,12606,19357,26972,15078,319161,12894,77053 Jak2,Top3a,Arntl,Rora,Med10,Nr3c1,Lmnb1,Med27,Hist2h4,H3f3b,Blm,Egr2,H2afz,Med15,Cry1,Med13,Nampt,Ncoa3,Lmna,Polr1d,Dnmt1,Irs2,Thrap3,Sun2,Socs3,Hist2h3c2,Syne1,Bhlhe41,Med30,Dbp,Csnk1e,Klf4,Irs1,Rxra,Cry2,F7,H2afy,Hist1h2ba,Med4,Med13l,Mlh1,Btrc,Srebf1,Npas2,Ncor2,Cdk8,Stat5a,Ppargc1a,Cebpa,Rad21,Spo11,H3f3a,Hist1h4n,Cpt1a,Sun1 R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence 0.987050534713662 -0.0130340405415534 44 7 0.00275590551181102 2540 8688 319161,12447,17535,22059,16906,97122,15364 Hist1h4n,Ccne1,Mre11a,Trp53,Lmnb1,Hist2h4,Hmga2 R-MMU-69580 p53-Dependent G1/S DNA damage checkpoint 0.987086161726562 -0.0129979467766508 62 11 0.00433070866141732 2540 8688 26440,17463,103554,26443,17246,66998,66997,12447,22059,59029,17248 Psma1,Psmd7,Psme4,Psma6,Mdm2,Psmd5,Psmd12,Ccne1,Trp53,Psmd14,Mdm4 R-MMU-69563 p53-Dependent G1 DNA Damage Response 0.987086161726562 -0.0129979467766508 62 11 0.00433070866141732 2540 8688 17246,26443,103554,26440,17463,17248,22059,59029,66997,12447,66998 Mdm2,Psma6,Psme4,Psma1,Psmd7,Mdm4,Trp53,Psmd14,Psmd12,Ccne1,Psmd5 R-MMU-6782135 Dual incision in TC-NER 0.987086161726562 -0.0129979467766508 62 11 0.00433070866141732 2540 8688 319955,71101,69263,56438,17420,27015,19687,13870,67439,13871,18972 Ercc6,Uvssa,Rfc3,Rbx1,Mnat1,Polk,Rfc1,Ercc1,Xab2,Ercc2,Pold2 R-MMU-211935 Fatty acids 0.98766929530286 -0.0124073586193458 19 2 0.00078740157480315 2540 8688 230639,13109 Cyp4a29,Cyp2j5 R-MMU-176412 Phosphorylation of the APC/C 0.98766929530286 -0.0124073586193458 19 2 0.00078740157480315 2540 8688 22194,56317 Ube2e1,Anapc7 R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.987772510412967 -0.012302860364928 88 17 0.00669291338582677 2540 8688 20088,14109,19704,20090,14852,66475,19921,57808,19946,68436,56040,67115,11837,19981,267019,19944,100502825 Rps24,Fau,Upf1,Rps29,Gspt1,Rps23,Rpl19,Rpl35a,Rpl30,Rpl34,Rplp1,Rpl14,Rplp0,Rpl37a,Rps15a,Rpl29,Rpl37rt R-MMU-2262752 Cellular responses to stress 0.987841542699818 -0.0122329759795943 360 87 0.034251968503937 2540 8688 26443,15081,15901,74302,16476,29806,19744,112407,66096,23871,103554,17969,74370,71805,17248,17970,66371,74244,13819,26399,17246,15364,26440,15251,20111,22084,66734,11927,17164,52639,67443,227720,11758,15078,15516,17535,22166,29810,12447,66997,56438,13875,225326,23872,16906,97122,20112,14778,12418,56637,12323,26416,50490,66998,12571,15481,14782,108058,97114,17463,228361,26419,22059,54383,68196,108079,78610,15511,57436,12359,56317,66795,19069,108099,59029,75608,216850,22194,20657,70369,17684,319161,112405,218210,18033,20655,68576 Psma6,H3f3b,Id1,Mtmr3,Jun,Limd1,Rheb,Egln3,Lamtor4,Ets1,Psme4,Ncf1,Rptor,Nup93,Mdm4,Ncf2,Chmp4c,Atg7,Epas1,Map2k6,Mdm2,Hmga2,Psma1,Hif1a,Rps6ka1,Tsc2,Map1lc3a,Atox1,Mapkapk2,Wipi1,Map1lc3b,Nup214,Prdx6,H3f3a,Hsp90ab1,Mre11a,Txn1,Bag3,Ccne1,Psmd12,Rbx1,Erf,Pik3c3,Ets2,Lmnb1,Hist2h4,Rps6ka2,Gpx3,Cbx4,Gsk3b,Camk2b,Mapk14,Nox4,Psmd5,Cdk6,Hspa8,Gsr,Camk2d,Hist2h3c2,Psmd7,Ambra1,Mapk8,Trp53,Phc2,Hsbp1,Prkaa2,Uvrag,Hspa1b,Gabarapl1,Cat,Anapc7,Atg10,Nup88,Prkag2,Psmd14,Chmp4b,Kdm6b,Ube2e1,Sod3,Bag5,Cited2,Hist1h4n,Egln1,Nup153,Nfkb1,Sod1,Lamtor5 R-MMU-112382 Formation of RNA Pol II elongation complex 0.988056347883806 -0.0120155505894888 58 10 0.00393700787401575 2540 8688 54624,67655,70122,20924,17420,13716,235497,13871,24116,72949 Paf1,Ctdp1,Mllt3,Supt5,Mnat1,Ell,Leo1,Ercc2,Nelfa,Ccnt2 R-MMU-75955 RNA Polymerase II Transcription Elongation 0.988056347883806 -0.0120155505894888 58 10 0.00393700787401575 2540 8688 70122,17420,20924,54624,67655,72949,24116,13871,13716,235497 Mllt3,Mnat1,Supt5,Paf1,Ctdp1,Ccnt2,Nelfa,Ercc2,Ell,Leo1 R-MMU-174143 APC/C-mediated degradation of cell cycle proteins 0.988183773226266 -0.0118865932413657 84 16 0.0062992125984252 2540 8688 103554,17463,27401,229776,66997,18005,56150,12234,26440,56317,107995,26443,22194,12237,66998,59029 Psme4,Psmd7,Skp2,Cdc14a,Psmd12,Nek2,Mad2l1,Btrc,Psma1,Anapc7,Cdc20,Psma6,Ube2e1,Bub3,Psmd5,Psmd14 R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition 0.988183773226266 -0.0118865932413657 84 16 0.0062992125984252 2540 8688 12234,22628,73738,18005,329251,214444,227613,19088,27373,18472,13191,71648,76707,77744,103583,99100 Btrc,Ywhag,Haus7,Nek2,Ppp1r12b,Cdk5rap2,Tubb4b,Prkar2b,Csnk1e,Pafah1b1,Dctn1,Optn,Clasp1,Bora,Fbxw11,Cep152 R-MMU-453276 Regulation of mitotic cell cycle 0.988183773226266 -0.0118865932413657 84 16 0.0062992125984252 2540 8688 229776,66997,27401,103554,17463,59029,22194,12237,66998,56317,26443,107995,56150,18005,26440,12234 Cdc14a,Psmd12,Skp2,Psme4,Psmd7,Psmd14,Ube2e1,Bub3,Psmd5,Anapc7,Psma6,Cdc20,Mad2l1,Nek2,Psma1,Btrc R-MMU-977441 GABA A receptor activation 0.988883453897944 -0.0111787966714873 13 1 0.000393700787401575 2540 8688 110886 Gabra5 R-MMU-2151201 Transcriptional activation of mitochondrial biogenesis 0.988883453897944 -0.0111787966714873 13 1 0.000393700787401575 2540 8688 19017 Ppargc1a R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1 0.989133335545512 -0.0109261378970715 54 9 0.00354330708661417 2540 8688 59029,66997,66998,107995,26443,103554,12234,17463,26440 Psmd14,Psmd12,Psmd5,Cdc20,Psma6,Psme4,Btrc,Psmd7,Psma1 R-MMU-392499 Metabolism of proteins 0.989469661683564 -0.0105861746586032 1115 294 0.115748031496063 2540 8688 19946,14677,21812,20088,110265,19211,89867,19944,235497,229595,105522,231050,107260,54624,50798,20449,59029,16010,19069,78754,12042,11735,15387,109676,171212,225131,18793,21825,22214,16009,66482,19244,330908,71954,20742,320311,320840,22193,235505,107895,67768,20610,108153,66212,18970,110379,74996,73582,66341,23802,329777,56176,76509,22166,230145,22213,19326,27401,14526,211446,11551,20334,18442,56040,16333,68436,59040,235441,78943,11889,27058,20090,22034,11553,20441,56336,14465,17380,22059,237847,16324,17463,12984,66967,12313,381694,17156,66789,109161,100683,11647,93841,67857,545260,72061,16000,98388,56233,77125,57808,50873,107976,67561,22258,100502825,26938,235661,23794,216131,11890,21838,50935,14068,21787,17829,12182,15251,67819,17127,11545,215494,234700,22217,330817,16795,69048,71897,11837,227720,74091,19981,78928,13809,66998,17126,15481,11606,20698,108150,108148,12144,59021,76687,18035,14109,12314,16006,16005,54383,14607,107607,17425,18548,22030,22194,66568,20440,13000,226641,77038,67196,94192,19357,16323,20450,13982,18550,26409,244682,50933,227327,56358,21951,12021,67099,12006,13036,107995,26443,16011,17131,271970,17342,27392,67204,109359,23956,71805,20444,268890,13191,14696,218138,20454,242362,21973,19921,74256,29858,17918,67665,13032,53869,72433,14678,269181,19359,30937,227195,66313,14799,71974,67952,327799,218476,231605,241230,19739,12945,217337,66475,12418,99412,23850,56494,54342,27223,19128,21802,14537,13426,14693,20447,20442,67115,13666,53625,77739,241062,226026,230815,18491,230801,68404,11650,218210,225280,69641,329908,14376,68135,267019,232984,109978,67542,22428,14852,56395,67128,229603,233744,64138,100042807,76800,68501,66286,17248,74008,14584,14462,103554,14702,30060,11835,192193,16008,72978,235106,12876,20813,53618,26440,66510,17246,21969,70495,66997,22031,69608,56505,80294,16319,271786,20338 Rpl30,Gnai1,Tgfbr1,Rps24,Msra,Pten,Sec16b,Rpl29,Leo1,Adamtsl4,Ankrd28,Galnt11,Otub1,Paf1,Gne,St8sia1,Psmd14,Igfbp4,Nup88,Galnt15,Bcl10,Ank3,Hnrnpk,Ank2,Galnt10,Wac,Plaur,Thbs1,Ube2h,Igfbp3,Exoc2,Ptp4a2,Opcml,Suds3,Sptbn1,Rnf152,Negr1,Ube2e3,Cd109,Mgat5,N6amt1,Sumo3,Adamts7,Sec61b,Polb,Sec13,Usp47,Camkmt,Eid3,Amfr,Pigk,Pigp,Plet1,Txn1,Galnt12,Ube2g2,Rab11b,Skp2,Gcg,Exoc3,Adra2a,Sec23a,P2ry2,Rplp1,Ins1,Rpl34,Rhot1,Usp3,Ern1,Asgr1,Srp9,Rps29,Traf6,Adra2c,St3gal3,B4galt5,Gata6,Mme,Trp53,Rtn4rl1,Inhbb,Psmd7,Csf2rb2,Edem3,Calm1,B3glct,Man1a2,Alg14,Ube2q2,Trrap,Alpl,Uchl4,Ppp6c,Arsi,Aopep,Igf1,Chst10,Hdac7,Il33,Rpl35a,Prkn,Babam2,Wdr48,Usp4,Rpl37rt,St6galnac5,Dync1li1,Adamts5,Trappc10,Asgr2,Thy1,St6galnac6,F7,Tfg,Muc1,Bst1,Hif1a,Derl1,Smad3,Parp1,Pomgnt2,Nrn1l,Usp12,Dhps,Large1,Slc30a5,Lypd6b,Rplp0,Nup214,Npl,Rpl37a,Pigt,Enpep,Psmd5,Smad2,Hspa8,Agt,Sphk1,Galnt7,Galnt2,Blm,Rab2a,Spcs3,Nfkbia,Fau,Calm2,Igfbp1,Igfals,Phc2,Gip,Nod1,Foxk1,Pcsk1,Traf2,Ube2e1,Rwdd3,St6gal1,Csnk2a2,Atf6,Arfgap2,Ube2t,C1galt1,Rad21,Inhba,St8sia2,Esr1,Furin,Map3k7,Cntn5,Uchl3,B3gnt7,Copz2,Tnks,Bard1,Mettl21a,Axin2,Ctsh,Cdc20,Psma6,Igfbp5,Smad7,Arsj,Mitf,Pign,Eif2s2,Abraxas2,Neu2,Nup93,St3gal2,Lsamp,Dctn1,Gnb4,Gmds,St3gal5,Manea,Top2a,Rpl19,Cyld,Pmm1,Myo5a,Dctn4,Ctsc,Rab11a,Rab38,Gnai2,Mgat4a,Rad23b,Lmcd1,Ino80d,Smurf2,Gria1,Prmt3,Tomm20,Usp44,Gcnt4,Galnt9,St8sia6,Rgs9,Dmbt1,Srp68,Rps23,Cbx4,Golga2,Pappa2,Gosr2,Gnpnat1,Trp53bp1,Pros1,Tgfa,Gcnt1,Dync1i1,Gnb2,St6galnac3,St3gal1,Rpl14,Eif2ak3,B3gnt2,Adamtsl1,Pgap1,Smc5,Man1c1,Pappa,Pigv,Nrn1,Alppl2,Nup153,Ino80c,Wdr20,Usp24,Ganab,Eif3h,Rps15a,B3gnt8,Art4,Cog6,Dctn6,Gspt1,Tmem115,Ube2g1,Otud7b,Spon1,Ctsz,Eif3j2,Usp42,Nsmce2,Sec11c,Mdm4,Arsg,Gfpt2,Gata3,Psme4,Gng2,Meltf,Ar,Edem1,Igfbp2,Cnih3,Ntm,Cpe,Srp14,Fut8,Psma1,Rnf181,Mdm2,Top1,Atp6ap2,Psmd12,Traf3,Sec24d,Ruvbl1,Pofut2,Incenp,Galnt13,Sel1l R-MMU-4570464 SUMOylation of RNA binding proteins 0.989558348613727 -0.0104965479026788 45 7 0.00275590551181102 2540 8688 12418,19069,15387,71805,218210,227720,54383 Cbx4,Nup88,Hnrnpk,Nup93,Nup153,Nup214,Phc2 R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.989558348613727 -0.0104965479026788 45 7 0.00275590551181102 2540 8688 17420,72949,20924,13871,24116,13716,67655 Mnat1,Ccnt2,Supt5,Ercc2,Nelfa,Ell,Ctdp1 R-MMU-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.98975970140444 -0.0102930911702901 72 13 0.00511811023622047 2540 8688 59029,22194,12237,66998,66997,56317,26443,107995,18005,103554,56150,17463,26440 Psmd14,Ube2e1,Bub3,Psmd5,Psmd12,Anapc7,Psma6,Cdc20,Nek2,Psme4,Mad2l1,Psmd7,Psma1 R-MMU-390522 Striated Muscle Contraction 0.991030676506737 -0.00900979002858779 31 4 0.0015748031496063 2540 8688 233199,21956,22003,59069 Mybpc2,Tnnt2,Tpm1,Tpm3 R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.991114092257219 -0.00892562286598092 55 9 0.00354330708661417 2540 8688 26443,103554,17463,26440,59029,448987,56438,66997,66998 Psma6,Psme4,Psmd7,Psma1,Psmd14,Fbxl7,Rbx1,Psmd12,Psmd5 R-MMU-69615 G1/S DNA Damage Checkpoints 0.991124769409998 -0.00891485004441425 64 11 0.00433070866141732 2540 8688 17248,59029,22059,12447,66998,66997,17246,26443,103554,17463,26440 Mdm4,Psmd14,Trp53,Ccne1,Psmd5,Psmd12,Mdm2,Psma6,Psme4,Psmd7,Psma1 R-MMU-774815 Nucleosome assembly 0.991162869444947 -0.00887640957371079 41 6 0.00236220472440945 2540 8688 97122,12617,56505,66311,319161,66578 Hist2h4,Cenpc1,Ruvbl1,Cenpw,Hist1h4n,Mis18a R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.991162869444947 -0.00887640957371079 41 6 0.00236220472440945 2540 8688 66311,319161,66578,97122,12617,56505 Cenpw,Hist1h4n,Mis18a,Hist2h4,Cenpc1,Ruvbl1 R-MMU-75953 RNA Polymerase II Transcription Initiation 0.991603944837769 -0.0084315005739024 46 7 0.00275590551181102 2540 8688 74197,17420,228980,68776,99730,83602,13871 Gtf2e1,Mnat1,Taf4,Taf11,Taf13,Gtf2a1,Ercc2 R-MMU-73776 RNA Polymerase II Promoter Escape 0.991603944837769 -0.0084315005739024 46 7 0.00275590551181102 2540 8688 99730,83602,13871,74197,17420,68776,228980 Taf13,Gtf2a1,Ercc2,Gtf2e1,Mnat1,Taf11,Taf4 R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.991603944837769 -0.0084315005739024 46 7 0.00275590551181102 2540 8688 228980,68776,17420,74197,13871,83602,99730 Taf4,Taf11,Mnat1,Gtf2e1,Ercc2,Gtf2a1,Taf13 R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.991603944837769 -0.0084315005739024 46 7 0.00275590551181102 2540 8688 228980,68776,74197,17420,83602,99730,13871 Taf4,Taf11,Gtf2e1,Mnat1,Gtf2a1,Taf13,Ercc2 R-MMU-113510 E2F mediated regulation of DNA replication 0.991703260827717 -0.0083313486763581 26 3 0.00118110236220472 2540 8688 12447,13555,73699 Ccne1,E2f1,Ppp2r1b R-MMU-977606 Regulation of Complement cascade 0.991703260827717 -0.0083313486763581 26 3 0.00118110236220472 2540 8688 17221,12279,12268 Cd46,C9,C4b R-MMU-391903 Eicosanoid ligand-binding receptors 0.992138327340831 -0.00789273853461777 14 1 0.000393700787401575 2540 8688 19220 Ptgfr R-MMU-69166 Removal of the Flap Intermediate 0.992138327340831 -0.00789273853461777 14 1 0.000393700787401575 2540 8688 18972 Pold2 R-MMU-191859 snRNP Assembly 0.992153728602032 -0.00787721535479597 51 8 0.0031496062992126 2540 8688 237221,53975,218210,71805,20643,19069,227720,107686 Gemin8,Ddx20,Nup153,Nup93,Snrpe,Nup88,Nup214,Snrpd2 R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.992153728602032 -0.00787721535479597 51 8 0.0031496062992126 2540 8688 17463,26440,103554,26443,66998,66997,59029,22059 Psmd7,Psma1,Psme4,Psma6,Psmd5,Psmd12,Psmd14,Trp53 R-MMU-194441 Metabolism of non-coding RNA 0.992153728602032 -0.00787721535479597 51 8 0.0031496062992126 2540 8688 71805,218210,53975,237221,107686,227720,19069,20643 Nup93,Nup153,Ddx20,Gemin8,Snrpd2,Nup214,Nup88,Snrpe R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.992859299428142 -0.00716631739507311 74 13 0.00511811023622047 2540 8688 59029,22194,66997,66998,12237,56317,26443,107995,18005,56150,103554,17463,26440 Psmd14,Ube2e1,Psmd12,Psmd5,Bub3,Anapc7,Psma6,Cdc20,Nek2,Mad2l1,Psme4,Psmd7,Psma1 R-MMU-176187 Activation of ATR in response to replication stress 0.992874920055927 -0.00715058454660618 37 5 0.00196850393700787 2540 8688 17219,69263,19356,12545,15574 Mcm6,Rfc3,Rad17,Cdc7,Hus1 R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.993266873482392 -0.00675589627930452 47 7 0.00275590551181102 2540 8688 242425,54393,83770,14816,12374,57254,387347 Gabbr2,Gabbr1,Tas1r2,Grm1,Casr,Tas2r119,Tas2r118 R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.993266873482392 -0.00675589627930452 47 7 0.00275590551181102 2540 8688 59029,26443,17463,66998,66997,26440,103554 Psmd14,Psma6,Psmd7,Psmd5,Psmd12,Psma1,Psme4 R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.993362146772284 -0.00665998175375118 61 10 0.00393700787401575 2540 8688 19687,27015,17420,56438,69263,319955,71101,18972,13871,67439 Rfc1,Polk,Mnat1,Rbx1,Rfc3,Ercc6,Uvssa,Pold2,Ercc2,Xab2 R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry 0.993959216506735 -0.00605910283859581 66 11 0.00433070866141732 2540 8688 26440,17463,26443,22390,27401,12447,66998,66997,12443,59029,17420 Psma1,Psmd7,Psma6,Wee1,Skp2,Ccne1,Psmd5,Psmd12,Ccnd1,Psmd14,Mnat1 R-MMU-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.994057134198134 -0.00596059490485251 75 13 0.00511811023622047 2540 8688 59029,66997,12237,66998,22194,26443,107995,56317,26440,17463,56150,103554,18005 Psmd14,Psmd12,Bub3,Psmd5,Ube2e1,Psma6,Cdc20,Anapc7,Psma1,Psmd7,Mad2l1,Psme4,Nek2 R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes 0.994057134198134 -0.00596059490485251 75 13 0.00511811023622047 2540 8688 27373,51885,227613,19088,18472,99100,214444,101706,76707,18005,22628,73738,13191 Csnk1e,Tubgcp4,Tubb4b,Prkar2b,Pafah1b1,Cep152,Cdk5rap2,Numa1,Clasp1,Nek2,Ywhag,Haus7,Dctn1 R-MMU-380287 Centrosome maturation 0.994057134198134 -0.00596059490485251 75 13 0.00511811023622047 2540 8688 13191,22628,18005,73738,76707,101706,214444,99100,18472,19088,227613,51885,27373 Dctn1,Ywhag,Nek2,Haus7,Clasp1,Numa1,Cdk5rap2,Cep152,Pafah1b1,Prkar2b,Tubb4b,Tubgcp4,Csnk1e R-MMU-4641258 Degradation of DVL 0.994103402286556 -0.00591405129071081 57 9 0.00354330708661417 2540 8688 26443,26440,17463,103554,13542,59029,66997,66998,56438 Psma6,Psma1,Psmd7,Psme4,Dvl1,Psmd14,Psmd12,Psmd5,Rbx1 R-MMU-453274 Mitotic G2-G2/M phases 0.994312952529444 -0.00570328029885474 167 35 0.0137795275590551 2540 8688 18005,12234,13557,26440,329251,214444,59029,27373,227613,15516,21664,101706,71648,448987,103583,99100,56438,66997,51885,73738,22628,73699,26443,22390,66998,18472,17420,19088,13191,103554,13555,17463,77744,76707,22059 Nek2,Btrc,E2f3,Psma1,Ppp1r12b,Cdk5rap2,Psmd14,Csnk1e,Tubb4b,Hsp90ab1,Phlda1,Numa1,Optn,Fbxl7,Fbxw11,Cep152,Rbx1,Psmd12,Tubgcp4,Haus7,Ywhag,Ppp2r1b,Psma6,Wee1,Psmd5,Pafah1b1,Mnat1,Prkar2b,Dctn1,Psme4,E2f1,Psmd7,Bora,Clasp1,Trp53 R-MMU-427359 SIRT1 negatively regulates rRNA Expression 0.994421564585591 -0.0055940529934297 38 5 0.00196850393700787 2540 8688 319161,97114,15081,97122,15078 Hist1h4n,Hist2h3c2,H3f3b,Hist2h4,H3f3a R-MMU-69183 Processive synthesis on the lagging strand 0.994440454231702 -0.00557505756193953 15 1 0.000393700787401575 2540 8688 18972 Pold2 R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.994529427532981 -0.00548559084637558 71 12 0.0047244094488189 2540 8688 22194,12237,66998,66997,59029,56150,103554,17463,26440,56317,107995,26443 Ube2e1,Bub3,Psmd5,Psmd12,Psmd14,Mad2l1,Psme4,Psmd7,Psma1,Anapc7,Cdc20,Psma6 R-MMU-380259 Loss of Nlp from mitotic centrosomes 0.995033593793139 -0.0049787797873181 67 11 0.00433070866141732 2540 8688 18472,19088,227613,27373,214444,99100,76707,13191,22628,73738,18005 Pafah1b1,Prkar2b,Tubb4b,Csnk1e,Cdk5rap2,Cep152,Clasp1,Dctn1,Ywhag,Haus7,Nek2 R-MMU-73886 Chromosome Maintenance 0.995033593793139 -0.0049787797873181 67 11 0.00433070866141732 2540 8688 97122,319161,66311,18974,18972,19687,245474,56505,12617,69263,66578 Hist2h4,Hist1h4n,Cenpw,Pole2,Pold2,Rfc1,Dkc1,Ruvbl1,Cenpc1,Rfc3,Mis18a R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.995033593793139 -0.0049787797873181 67 11 0.00433070866141732 2540 8688 99100,214444,227613,19088,27373,18472,13191,73738,22628,18005,76707 Cep152,Cdk5rap2,Tubb4b,Prkar2b,Csnk1e,Pafah1b1,Dctn1,Haus7,Ywhag,Nek2,Clasp1 R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase 0.995064750362302 -0.00494746819987135 76 13 0.00511811023622047 2540 8688 22194,66998,12237,66997,59029,56150,103554,17463,12234,26440,56317,107995,26443 Ube2e1,Psmd5,Bub3,Psmd12,Psmd14,Mad2l1,Psme4,Psmd7,Btrc,Psma1,Anapc7,Cdc20,Psma6 R-MMU-6799198 Complex I biogenesis 0.995214085751571 -0.00479740340810485 58 9 0.00354330708661417 2540 8688 26940,68194,17993,66916,76826,69875,68493,67184,75406 Ecsit,Ndufb4,Ndufs4,Ndufb7,Nubpl,Ndufa11,Ndufaf4,Ndufa13,Ndufs7 R-MMU-5676590 NIK-->noncanonical NF-kB signaling 0.995214085751571 -0.00479740340810485 58 9 0.00354330708661417 2540 8688 26443,12234,17463,26440,103554,59029,103583,66997,66998 Psma6,Btrc,Psmd7,Psma1,Psme4,Psmd14,Fbxw11,Psmd12,Psmd5 R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.995214085751571 -0.00479740340810485 58 9 0.00354330708661417 2540 8688 17463,26440,103554,15516,26443,66998,66997,59029,22059 Psmd7,Psma1,Psme4,Hsp90ab1,Psma6,Psmd5,Psmd12,Psmd14,Trp53 R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.995214085751571 -0.00479740340810485 58 9 0.00354330708661417 2540 8688 66997,66998,103583,59029,26440,17463,12234,103554,26443 Psmd12,Psmd5,Fbxw11,Psmd14,Psma1,Psmd7,Btrc,Psme4,Psma6 R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.995244066298478 -0.00476727914060584 28 3 0.00118110236220472 2540 8688 20924,17420,13871 Supt5,Mnat1,Ercc2 R-MMU-6803529 FGFR2 alternative splicing 0.995244066298478 -0.00476727914060584 28 3 0.00118110236220472 2540 8688 93686,207920,59013 Rbfox2,Esrp1,Hnrnph1 R-MMU-75067 Processing of Capped Intronless Pre-mRNA 0.995244066298478 -0.00476727914060584 28 3 0.00118110236220472 2540 8688 72290,20643,18789 Lsm11,Snrpe,Papola R-MMU-6807505 RNA polymerase II transcribes snRNA genes 0.995483372746302 -0.00452685803193618 72 12 0.0047244094488189 2540 8688 63856,75627,101861,68776,18130,192657,83602,99730,13716,218333,74197,72949 Taf8,Snapc1,Ints4,Taf11,Ints6,Ell2,Gtf2a1,Taf13,Ell,Ice1,Gtf2e1,Ccnt2 R-MMU-166658 Complement cascade 0.995643576783094 -0.00436594007823683 39 5 0.00196850393700787 2540 8688 12268,11537,239447,17221,12279 C4b,Cfd,Colec10,Cd46,C9 R-MMU-5696398 Nucleotide Excision Repair 0.995786604056151 -0.00422229730865364 103 19 0.00748031496062992 2540 8688 227195,319955,19359,56438,56505,225280,27015,19687,13871,13870,67439,20610,71101,69263,17420,108679,70620,18972,11545 Ino80d,Ercc6,Rad23b,Rbx1,Ruvbl1,Ino80c,Polk,Rfc1,Ercc2,Ercc1,Xab2,Sumo3,Uvssa,Rfc3,Mnat1,Cops8,Ube2v2,Pold2,Parp1 R-MMU-5689901 Metalloprotease DUBs 0.995884308349234 -0.00412418442007049 34 4 0.0015748031496063 2540 8688 109359,59029,12021,107976 Abraxas2,Psmd14,Bard1,Babam2 R-MMU-72649 Translation initiation complex formation 0.995887622030596 -0.00412085704979143 54 8 0.0031496062992126 2540 8688 100042807,66475,67204,68135,20090,20088,14109,267019 Eif3j2,Rps23,Eif2s2,Eif3h,Rps29,Rps24,Fau,Rps15a R-MMU-3214847 HATs acetylate histones 0.995910195288597 -0.00409819083557498 77 13 0.00511811023622047 2540 8688 76719,228829,70088,269424,54169,107435,18505,319177,97122,15078,97114,15081,319161 Kansl1,Phf20,Meaf6,Jade1,Kat6b,Hat1,Pax3,Hist1h2ba,Hist2h4,H3f3a,Hist2h3c2,H3f3b,Hist1h4n R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.99592599268155 -0.0040823286948545 68 11 0.00433070866141732 2540 8688 20111,12571,18033,22194,15078,56317,97122,20112,97114,15081,319161 Rps6ka1,Cdk6,Nfkb1,Ube2e1,H3f3a,Anapc7,Hist2h4,Rps6ka2,Hist2h3c2,H3f3b,Hist1h4n R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 0.996124619671585 -0.00388290907221793 59 9 0.00354330708661417 2540 8688 26443,27401,26440,17463,59029,12447,66997,66998,12443 Psma6,Skp2,Psma1,Psmd7,Psmd14,Ccne1,Psmd12,Psmd5,Ccnd1 R-MMU-69620 Cell Cycle Checkpoints 0.996141791025688 -0.0038656710622699 178 37 0.0145669291338583 2540 8688 12545,22194,59029,19356,26440,56150,56317,17120,17246,15574,17219,66997,12447,17535,319161,69263,66998,12237,21975,70620,107976,12021,225182,12144,22628,22630,26443,22390,107995,97122,27223,223970,22059,17248,17463,103554,22631 Cdc7,Ube2e1,Psmd14,Rad17,Psma1,Mad2l1,Anapc7,Mad1l1,Mdm2,Hus1,Mcm6,Psmd12,Ccne1,Mre11a,Hist1h4n,Rfc3,Psmd5,Bub3,Top3a,Ube2v2,Babam2,Bard1,Rbbp8,Blm,Ywhag,Ywhaq,Psma6,Wee1,Cdc20,Hist2h4,Trp53bp1,Rmi2,Trp53,Mdm4,Psmd7,Psme4,Ywhaz R-MMU-73894 DNA Repair 0.996174111195326 -0.00383322623802866 269 60 0.0236220472440945 2540 8688 57434,18294,319161,13870,67439,56438,19359,14048,268420,227195,19687,17535,27015,225280,56505,74335,19356,67196,26383,232314,67030,11545,17350,15574,71885,14087,14049,108679,20610,13871,26419,56626,101831,76843,18970,217365,223970,54125,319955,22059,107976,12021,225182,12144,18972,14088,19363,97122,27223,216835,16647,208836,22596,69263,71101,330554,21975,70620,193796,17420 Xrcc2,Ogg1,Hist1h4n,Ercc1,Xab2,Rbx1,Rad23b,Eya1,Alkbh5,Ino80d,Rfc1,Mre11a,Polk,Ino80c,Ruvbl1,Xrcc3,Rad17,Ube2t,Fto,Ppp4r2,Fancl,Parp1,Mlh1,Hus1,Faap100,Fanca,Eya2,Cops8,Sumo3,Ercc2,Mapk8,Poll,Faap24,Dtl,Polb,Nploc4,Rmi2,Polm,Ercc6,Trp53,Babam2,Bard1,Rbbp8,Blm,Pold2,Fancc,Rad51b,Hist2h4,Trp53bp1,Usp43,Kpna2,Fanci,Xrcc5,Rfc3,Uvssa,Fan1,Top3a,Ube2v2,Kdm4b,Mnat1 R-MMU-72689 Formation of a pool of free 40S subunits 0.996203417465369 -0.00380380784756439 95 17 0.00669291338582677 2540 8688 20090,20088,14109,19946,68436,56040,67115,66475,19921,57808,68135,11837,19981,267019,100042807,100502825,19944 Rps29,Rps24,Fau,Rpl30,Rpl34,Rplp1,Rpl14,Rps23,Rpl19,Rpl35a,Eif3h,Rplp0,Rpl37a,Rps15a,Eif3j2,Rpl37rt,Rpl29 R-MMU-72312 rRNA processing 0.996320668834934 -0.0036861165528826 125 24 0.0094488188976378 2540 8688 215193,73674,19944,68979,100502825,216987,67755,19981,213895,11837,67276,19921,57808,50912,57316,234374,14791,68436,56040,67115,19946,50911,66446,76130 Utp25,Wdr75,Rpl29,Nol11,Rpl37rt,Utp6,Ddx47,Rpl37a,Bms1,Rplp0,Eri1,Rpl19,Rpl35a,Exosc10,C1d,Ddx49,Emg1,Rpl34,Rplp1,Rpl14,Rpl30,Exosc9,Exosc7,Las1l R-MMU-8868773 rRNA processing in the nucleus and cytosol 0.996320668834934 -0.0036861165528826 125 24 0.0094488188976378 2540 8688 57808,19921,67276,234374,57316,50912,56040,67115,14791,68436,19946,50911,66446,76130,215193,73674,68979,19944,100502825,213895,216987,19981,67755,11837 Rpl35a,Rpl19,Eri1,Ddx49,C1d,Exosc10,Rplp1,Rpl14,Emg1,Rpl34,Rpl30,Exosc9,Exosc7,Las1l,Utp25,Wdr75,Nol11,Rpl29,Rpl37rt,Bms1,Utp6,Rpl37a,Ddx47,Rplp0 R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.996320668834934 -0.0036861165528826 125 24 0.0094488188976378 2540 8688 67276,19921,57808,50912,57316,234374,68436,14791,56040,67115,50911,19946,66446,76130,215193,19944,73674,68979,100502825,216987,67755,19981,213895,11837 Eri1,Rpl19,Rpl35a,Exosc10,C1d,Ddx49,Rpl34,Emg1,Rplp1,Rpl14,Exosc9,Rpl30,Exosc7,Las1l,Utp25,Rpl29,Wdr75,Nol11,Rpl37rt,Utp6,Ddx47,Rpl37a,Bms1,Rplp0 R-MMU-933541 TRAF6 mediated IRF7 activation 0.99634254060459 -0.00366416425351469 23 2 0.00078740157480315 2540 8688 15977,16363 Ifnb1,Irf2 R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.99634254060459 -0.00366416425351469 23 2 0.00078740157480315 2540 8688 13109,13078 Cyp2j5,Cyp1b1 R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6 0.99657955267885 -0.00342631042452988 50 7 0.00275590551181102 2540 8688 66997,66998,26440,17463,103554,26443,59029 Psmd12,Psmd5,Psma1,Psmd7,Psme4,Psma6,Psmd14 R-MMU-3247509 Chromatin modifying enzymes 0.996584055766258 -0.00342179189189321 191 40 0.015748031496063 2540 8688 225888,76804,319177,54169,216850,320595,11569,319161,15078,208266,18505,67014,18033,12443,71974,228829,70088,69726,15081,214162,66993,99982,97122,239985,70673,193796,226830,76719,67956,97114,18600,13435,20586,107435,338523,269424,14013,20588,67155,104263 Kmt5b,Kdm4c,Hist1h2ba,Kat6b,Kdm6b,Phf8,Aebp2,Hist1h4n,H3f3a,Dot1l,Pax3,Riox2,Nfkb1,Ccnd1,Prmt3,Phf20,Meaf6,Smyd3,H3f3b,Kmt2a,Smarcd3,Kdm1a,Hist2h4,Arid1b,Prdm16,Kdm4b,Smyd2,Kansl1,Kmt5a,Hist2h3c2,Padi2,Dnmt3a,Smarca4,Hat1,Kdm7a,Jade1,Mecom,Smarcc1,Smarca2,Kdm3a R-MMU-4839726 Chromatin organization 0.996584055766258 -0.00342179189189321 191 40 0.015748031496063 2540 8688 15078,208266,11569,319161,71974,228829,70088,18505,18033,67014,12443,319177,225888,76804,320595,54169,216850,20586,18600,97114,13435,14013,20588,269424,104263,67155,107435,338523,99982,97122,69726,214162,15081,66993,193796,226830,76719,67956,239985,70673 H3f3a,Dot1l,Aebp2,Hist1h4n,Prmt3,Phf20,Meaf6,Pax3,Nfkb1,Riox2,Ccnd1,Hist1h2ba,Kmt5b,Kdm4c,Phf8,Kat6b,Kdm6b,Smarca4,Padi2,Hist2h3c2,Dnmt3a,Mecom,Smarcc1,Jade1,Kdm3a,Smarca2,Hat1,Kdm7a,Kdm1a,Hist2h4,Smyd3,Kmt2a,H3f3b,Smarcd3,Kdm4b,Smyd2,Kansl1,Kmt5a,Arid1b,Prdm16 R-MMU-211859 Biological oxidations 0.996664680807078 -0.00334089376875953 231 50 0.0196850393700787 2540 8688 67768,58810,68214,394433,11622,13123,11864,232174,320997,56448,56050,13885,234673,107146,13070,13109,232087,230639,216558,66112,242585,231583,108652,13074,19224,11669,15516,21391,23971,23972,14149,18105,68044,72361,12846,20887,14148,228608,71670,20181,18984,13075,213012,211666,22235,13082,13078,19223,66427,54486 N6amt1,Akr1a1,Gsto2,Ugt1a5,Ahr,Cyp7b1,Arnt2,Cyp26b1,Cyp4f39,Cyp2d22,Cyp39a1,Esd,Ces2e,Glyat,Cyp11a1,Cyp2j5,Mat2a,Cyp4a29,Ugp2,Marc1,Slc35d1,Slc26a1,Slc35b3,Cyp17a1,Ptgs1,Aldh2,Hsp90ab1,Tbxas1,Papss1,Papss2,Fdxr,Nqo2,Chac2,Ces2g,Comt,Sult1a1,Fdx1,Smox,Acy3,Rxra,Por,Cyp19a1,Abhd10,Mgst2,Ugdh,Cyp26a1,Cyp1b1,Ptgis,Cyb5b,Hpgds R-MMU-72702 Ribosomal scanning and start codon recognition 0.996700137746077 -0.00330531880659241 55 8 0.0031496062992126 2540 8688 20088,267019,14109,20090,68135,67204,66475,100042807 Rps24,Rps15a,Fau,Rps29,Eif3h,Eif2s2,Rps23,Eif3j2 R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.996700137746077 -0.00330531880659241 55 8 0.0031496062992126 2540 8688 20090,68135,267019,14109,20088,100042807,67204,66475 Rps29,Eif3h,Rps15a,Fau,Rps24,Eif3j2,Eif2s2,Rps23 R-MMU-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.996940845630868 -0.00306384314676334 74 12 0.0047244094488189 2540 8688 67439,13871,13870,18972,71101,319955,69263,56438,17420,108679,27015,19687 Xab2,Ercc2,Ercc1,Pold2,Uvssa,Ercc6,Rfc3,Rbx1,Mnat1,Cops8,Polk,Rfc1 R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.996989863798706 -0.00301467577337788 143 28 0.0110236220472441 2540 8688 67184,16828,20916,110842,76187,75406,17993,381511,68194,11957,28080,76826,66916,14651,20181,22228,22227,68493,18115,66052,69875,106557,20501,269951,20917,26940,68263,22229 Ndufa13,Ldha,Sucla2,Etfa,Adhfe1,Ndufs7,Ndufs4,Pdp1,Ndufb4,Atp5j,Atp5o,Nubpl,Ndufb7,Hagh,Rxra,Ucp2,Ucp1,Ndufaf4,Nnt,Sdhc,Ndufa11,Ldhal6b,Slc16a1,Idh2,Suclg2,Ecsit,Pdhb,Ucp3 R-MMU-3214858 RMTs methylate histone arginines 0.99727620578729 -0.00272751048994974 70 11 0.00433070866141732 2540 8688 20586,97122,66993,319161,13435,97114,67155,20588,71974,12443,239985 Smarca4,Hist2h4,Smarcd3,Hist1h4n,Dnmt3a,Hist2h3c2,Smarca2,Smarcc1,Prmt3,Ccnd1,Arid1b R-MMU-8854518 AURKA Activation by TPX2 0.99727620578729 -0.00272751048994974 70 11 0.00433070866141732 2540 8688 18472,27373,19088,227613,214444,99100,76707,73738,18005,22628,13191 Pafah1b1,Csnk1e,Prkar2b,Tubb4b,Cdk5rap2,Cep152,Clasp1,Haus7,Nek2,Ywhag,Dctn1 R-MMU-72086 mRNA Capping 0.997297936776643 -0.00270572038559598 30 3 0.00118110236220472 2540 8688 13871,17420,20924 Ercc2,Mnat1,Supt5 R-MMU-5358346 Hedgehog ligand biogenesis 0.997475975529713 -0.00252721519015108 61 9 0.00354330708661417 2540 8688 59029,66998,66997,26443,226861,17463,26440,20338,103554 Psmd14,Psmd5,Psmd12,Psma6,Hhat,Psmd7,Psma1,Sel1l,Psme4 R-MMU-5620912 Anchoring of the basal body to the plasma membrane 0.99751199973614 -0.00249110047980968 93 16 0.0062992125984252 2540 8688 231214,99100,76707,13191,382090,18472,227613,19088,27373,68642,214444,53869,22628,18005,73738,27078 Cc2d2a,Cep152,Clasp1,Dctn1,Cep162,Pafah1b1,Tubb4b,Prkar2b,Csnk1e,Tmem216,Cdk5rap2,Rab11a,Ywhag,Nek2,Haus7,B9d1 R-MMU-69275 G2/M Transition 0.997533798965169 -0.00246924711780271 165 33 0.012992125984252 2540 8688 21664,15516,71648,101706,66997,99100,103583,56438,448987,51885,26440,12234,18005,329251,214444,227613,59029,27373,17463,13191,103554,77744,76707,22059,73738,22628,26443,22390,73699,66998,19088,17420,18472 Phlda1,Hsp90ab1,Optn,Numa1,Psmd12,Cep152,Fbxw11,Rbx1,Fbxl7,Tubgcp4,Psma1,Btrc,Nek2,Ppp1r12b,Cdk5rap2,Tubb4b,Psmd14,Csnk1e,Psmd7,Dctn1,Psme4,Bora,Clasp1,Trp53,Haus7,Ywhag,Psma6,Wee1,Ppp2r1b,Psmd5,Prkar2b,Mnat1,Pafah1b1 R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin 0.997620592426039 -0.00238224286259325 66 10 0.00393700787401575 2540 8688 66997,66998,22194,59029,17463,26440,103554,107995,26443,56317 Psmd12,Psmd5,Ube2e1,Psmd14,Psmd7,Psma1,Psme4,Cdc20,Psma6,Anapc7 R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.99777978182014 -0.00222268651842033 71 11 0.00433070866141732 2540 8688 103554,26440,17463,27401,56317,26443,107995,22194,66997,66998,59029 Psme4,Psma1,Psmd7,Skp2,Anapc7,Psma6,Cdc20,Ube2e1,Psmd12,Psmd5,Psmd14 R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.99777978182014 -0.00222268651842033 71 11 0.00433070866141732 2540 8688 19069,64340,66231,227720,71713,56488,218210,66441,71805,20383,73666 Nup88,Dhx38,Thoc7,Nup214,Cdc40,Nxt1,Nup153,Magohb,Nup93,Srsf3,Thoc3 R-MMU-72202 Transport of Mature Transcript to Cytoplasm 0.99777978182014 -0.00222268651842033 71 11 0.00433070866141732 2540 8688 218210,66441,71805,20383,73666,66231,227720,71713,56488,19069,64340 Nup153,Magohb,Nup93,Srsf3,Thoc3,Thoc7,Nup214,Cdc40,Nxt1,Nup88,Dhx38 R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.997847621651062 -0.00215469804438938 52 7 0.00275590551181102 2540 8688 26443,59029,103554,26440,66997,66998,17463 Psma6,Psmd14,Psme4,Psma1,Psmd12,Psmd5,Psmd7 R-MMU-69613 p53-Independent G1/S DNA damage checkpoint 0.997847621651062 -0.00215469804438938 52 7 0.00275590551181102 2540 8688 59029,26443,103554,17463,66998,26440,66997 Psmd14,Psma6,Psme4,Psmd7,Psmd5,Psma1,Psmd12 R-MMU-69610 p53-Independent DNA Damage Response 0.997847621651062 -0.00215469804438938 52 7 0.00275590551181102 2540 8688 59029,26443,103554,17463,26440,66997,66998 Psmd14,Psma6,Psme4,Psmd7,Psma1,Psmd12,Psmd5 R-MMU-68962 Activation of the pre-replicative complex 0.997969428937997 -0.00203263546650918 31 3 0.00118110236220472 2540 8688 18974,12545,17219 Pole2,Cdc7,Mcm6 R-MMU-73777 RNA Polymerase I Chain Elongation 0.997969428937997 -0.00203263546650918 31 3 0.00118110236220472 2540 8688 17420,20018,13871 Mnat1,Polr1d,Ercc2 R-MMU-68867 Assembly of the pre-replicative complex 0.998074451819938 -0.00192740443120871 67 10 0.00393700787401575 2540 8688 17219,66998,66997,59029,17463,13555,13557,26440,103554,26443 Mcm6,Psmd5,Psmd12,Psmd14,Psmd7,E2f1,E2f3,Psma1,Psme4,Psma6 R-MMU-927802 Nonsense-Mediated Decay (NMD) 0.998206186876747 -0.00179542393262916 108 19 0.00748031496062992 2540 8688 57808,19921,14852,66475,56040,67115,68436,19946,14109,20088,20090,52830,19704,66441,19944,100502825,267019,19981,11837 Rpl35a,Rpl19,Gspt1,Rps23,Rplp1,Rpl14,Rpl34,Rpl30,Fau,Rps24,Rps29,Pnrc2,Upf1,Magohb,Rpl29,Rpl37rt,Rps15a,Rpl37a,Rplp0 R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.998206186876747 -0.00179542393262916 108 19 0.00748031496062992 2540 8688 20090,52830,19704,14109,20088,67115,56040,68436,19946,57808,19921,66475,14852,267019,19981,11837,100502825,66441,19944 Rps29,Pnrc2,Upf1,Fau,Rps24,Rpl14,Rplp1,Rpl34,Rpl30,Rpl35a,Rpl19,Rps23,Gspt1,Rps15a,Rpl37a,Rplp0,Rpl37rt,Magohb,Rpl29 R-MMU-1852241 Organelle biogenesis and maintenance 0.998270683241873 -0.00173081375245279 276 60 0.0236220472440945 2540 8688 64657,214444,68642,212541,108099,227613,27373,75465,18005,238799,76260,53869,99100,56350,72938,73916,19017,66845,18763,26415,213081,211446,12589,264134,67840,13196,67068,66482,333329,319845,26416,18472,19088,217935,73242,64659,73738,22628,59054,16579,16569,27078,121022,66230,74682,16570,94062,108079,231214,106840,81896,71820,213575,13191,68537,67270,382090,215445,76707,60441 Mrps10,Cdk5rap2,Tmem216,Rho,Prkag2,Tubb4b,Csnk1e,Dynlrb2,Nek2,Tnpo1,Ttc8,Rab11a,Cep152,Arl3,Hspb11,Ift57,Ppargc1a,Mrpl33,Pkd1,Mapk13,Wdr19,Exoc3,Ift81,Ttc26,Mrpl57,Asap1,Dynlrb1,Exoc2,Cngb1,Bbs9,Mapk14,Pafah1b1,Prkar2b,Wdr60,Atat1,Mrps14,Haus7,Ywhag,Mrps30,Kifap3,Kif3b,B9d1,Mrps6,Mrps28,Wdr35,Kif3c,Mrpl3,Prkaa2,Cc2d2a,Unc119b,Ift122,Wdr34,Dync2li1,Dctn1,Mrpl13,Mrpl42,Cep162,Rab11fip3,Clasp1,Mrpl38 R-MMU-211945 Phase 1 - Functionalization of compounds 0.998309531732248 -0.00169189872155234 151 29 0.0114173228346457 2540 8688 66427,13074,11669,19224,18984,13075,66112,20181,19223,13078,13082,230639,234673,228608,13070,13109,56448,72361,14148,56050,232174,11864,14149,320997,18105,21391,13123,11622,15516 Cyb5b,Cyp17a1,Aldh2,Ptgs1,Por,Cyp19a1,Marc1,Rxra,Ptgis,Cyp1b1,Cyp26a1,Cyp4a29,Ces2e,Smox,Cyp11a1,Cyp2j5,Cyp2d22,Ces2g,Fdx1,Cyp39a1,Cyp26b1,Arnt2,Fdxr,Cyp4f39,Nqo2,Tbxas1,Cyp7b1,Ahr,Hsp90ab1 R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.998322850259962 -0.00167855773015725 104 18 0.00708661417322835 2540 8688 68135,11837,19981,267019,100042807,100502825,19944,67204,20090,20088,14109,19946,68436,67115,56040,66475,19921,57808 Eif3h,Rplp0,Rpl37a,Rps15a,Eif3j2,Rpl37rt,Rpl29,Eif2s2,Rps29,Rps24,Fau,Rpl30,Rpl34,Rpl14,Rplp1,Rps23,Rpl19,Rpl35a R-MMU-69481 G2/M Checkpoints 0.998358197789698 -0.00164315144453648 147 28 0.0110236220472441 2540 8688 17219,223970,66997,22059,17535,103554,17463,319161,22631,12545,69263,66998,21975,70620,59029,22630,22628,107976,225182,12144,12021,19356,26440,97122,27223,15574,26443,22390 Mcm6,Rmi2,Psmd12,Trp53,Mre11a,Psme4,Psmd7,Hist1h4n,Ywhaz,Cdc7,Rfc3,Psmd5,Top3a,Ube2v2,Psmd14,Ywhaq,Ywhag,Babam2,Rbbp8,Blm,Bard1,Rad17,Psma1,Hist2h4,Trp53bp1,Hus1,Psma6,Wee1 R-MMU-5250924 B-WICH complex positively regulates rRNA expression 0.998370062492429 -0.00163126730089368 63 9 0.00354330708661417 2540 8688 15078,97122,15081,97114,319161,17913,56637,20018,319955 H3f3a,Hist2h4,H3f3b,Hist2h3c2,Hist1h4n,Myo1c,Gsk3b,Polr1d,Ercc6 R-MMU-73772 RNA Polymerase I Promoter Escape 0.998476873562941 -0.00152428757331833 32 3 0.00118110236220472 2540 8688 13871,20018,17420 Ercc2,Polr1d,Mnat1 R-MMU-77595 Processing of Intronless Pre-mRNAs 0.99861027361776 -0.00139069294756036 19 1 0.000393700787401575 2540 8688 18789 Papola R-MMU-6781823 Formation of TC-NER Pre-Incision Complex 0.998657168267551 -0.00134373413892379 54 7 0.00275590551181102 2540 8688 67439,71101,13871,319955,56438,17420,108679 Xab2,Uvssa,Ercc2,Ercc6,Rbx1,Mnat1,Cops8 R-MMU-73856 RNA Polymerase II Transcription Termination 0.998694164280693 -0.00130668906573738 64 9 0.00354330708661417 2540 8688 73666,20383,66441,71713,66231,18789,64340,72290,20643 Thoc3,Srsf3,Magohb,Cdc40,Thoc7,Papola,Dhx38,Lsm11,Snrpe R-MMU-109688 Cleavage of Growing Transcript in the Termination Region 0.998694164280693 -0.00130668906573738 64 9 0.00354330708661417 2540 8688 66231,71713,18789,20643,72290,64340,20383,73666,66441 Thoc7,Cdc40,Papola,Snrpe,Lsm11,Dhx38,Srsf3,Thoc3,Magohb R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.998830901422017 -0.00116978250683142 106 18 0.00708661417322835 2540 8688 20090,20088,14109,19946,68436,67115,56040,66475,19921,57808,68135,11837,19981,267019,100042807,100502825,19944,67204 Rps29,Rps24,Fau,Rpl30,Rpl34,Rpl14,Rplp1,Rps23,Rpl19,Rpl35a,Eif3h,Rplp0,Rpl37a,Rps15a,Eif3j2,Rpl37rt,Rpl29,Eif2s2 R-MMU-73863 RNA Polymerase I Transcription Termination 0.998859504963521 -0.00114114589585851 33 3 0.00118110236220472 2540 8688 13871,20018,17420 Ercc2,Polr1d,Mnat1 R-MMU-72187 mRNA 3'-end processing 0.99894256856112 -0.00105799091394326 55 7 0.00275590551181102 2540 8688 20383,73666,66231,71713,66441,18789,64340 Srsf3,Thoc3,Thoc7,Cdc40,Magohb,Papola,Dhx38 R-MMU-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.998942813955179 -0.0010577452601518 27 2 0.00078740157480315 2540 8688 230639,13078 Cyp4a29,Cyp1b1 R-MMU-72766 Translation 0.999189086650329 -0.00081124231775656 130 23 0.00905511811023622 2540 8688 100502825,100042807,67204,19944,68135,67768,267019,19981,11837,67115,56040,68436,19946,20813,57808,27058,19921,66475,217337,14852,20090,14109,20088 Rpl37rt,Eif3j2,Eif2s2,Rpl29,Eif3h,N6amt1,Rps15a,Rpl37a,Rplp0,Rpl14,Rplp1,Rpl34,Rpl30,Srp14,Rpl35a,Srp9,Rpl19,Rps23,Srp68,Gspt1,Rps29,Fau,Rps24 R-MMU-5578749 Transcriptional regulation by small RNAs 0.999224028736364 -0.000776272485173589 76 11 0.00433070866141732 2540 8688 239528,15078,97122,227720,15081,319161,97114,19069,71805,218210,233833 Ago2,H3f3a,Hist2h4,Nup214,H3f3b,Hist1h4n,Hist2h3c2,Nup88,Nup93,Nup153,Tnrc6a R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.99933388916821 -0.000666332782178083 62 8 0.0031496062992126 2540 8688 26440,17463,56317,26443,22194,66997,66998,59029 Psma1,Psmd7,Anapc7,Psma6,Ube2e1,Psmd12,Psmd5,Psmd14 R-MMU-69278 Cell Cycle, Mitotic 0.999437358344316 -0.000562799997896382 438 99 0.0389763779527559 2540 8688 244329,18472,67956,12237,73699,26443,107995,26932,22628,67121,67629,18972,18974,244495,71805,77744,26951,18750,434233,13191,103554,70315,21973,16563,227613,110379,214444,17120,217718,329251,14245,18005,56150,100710,12234,18751,26440,226747,19687,51885,108000,448987,56438,103583,12447,66997,27401,101706,71648,66977,227720,15516,76499,16319,56637,17420,19088,208628,12571,69263,66998,97122,59021,22390,99412,73738,71175,22059,226849,83431,16905,76707,56430,13555,17463,12617,13000,59029,27373,320595,12545,22194,56317,22367,19069,13557,13548,72415,218210,229776,59126,272551,17219,11651,99100,12443,19357,21664,319161 Mcph1,Pafah1b1,Kmt5a,Bub3,Ppp2r1b,Psma6,Cdc20,Ppp2r5e,Ywhag,Mastl,Spc24,Pold2,Pole2,Sgo2b,Nup93,Bora,Zw10,Prkca,Ppp1ccb,Dctn1,Psme4,Hdac8,Top2a,Kif2a,Tubb4b,Sec13,Cdk5rap2,Mad1l1,Nek9,Ppp1r12b,Lpin1,Nek2,Mad2l1,Pds5b,Btrc,Prkcb,Psma1,Ahctf1,Rfc1,Tubgcp4,Cenpf,Fbxl7,Rbx1,Fbxw11,Ccne1,Psmd12,Skp2,Numa1,Optn,Nuf2,Nup214,Hsp90ab1,Clasp2,Incenp,Gsk3b,Mnat1,Prkar2b,Kntc1,Cdk6,Rfc3,Psmd5,Hist2h4,Rab2a,Wee1,Golga2,Haus7,Nipbl,Trp53,Ppp2r5a,Ndel1,Lmna,Clasp1,Clip1,E2f1,Psmd7,Cenpc1,Csnk2a2,Psmd14,Csnk1e,Phf8,Cdc7,Ube2e1,Anapc7,Vrk1,Nup88,E2f3,Dyrk1a,Sgo1,Nup153,Cdc14a,Nek6,Gins2,Mcm6,Akt1,Cep152,Ccnd1,Rad21,Phlda1,Hist1h4n R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex 0.999489491534387 -0.000510638819426086 58 7 0.00275590551181102 2540 8688 59029,26443,17463,66998,26440,66997,103554 Psmd14,Psma6,Psmd7,Psmd5,Psma1,Psmd12,Psme4 R-MMU-69242 S Phase 0.999501690092093 -0.000498434105549754 124 21 0.00826771653543307 2540 8688 66998,69263,59029,56637,17420,100710,26440,18972,18974,26443,22390,12443,17219,12447,66997,19357,272551,19687,17463,103554,27401 Psmd5,Rfc3,Psmd14,Gsk3b,Mnat1,Pds5b,Psma1,Pold2,Pole2,Psma6,Wee1,Ccnd1,Mcm6,Ccne1,Psmd12,Rad21,Gins2,Rfc1,Psmd7,Psme4,Skp2 R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.99951136363056 -0.000488755791094353 97 15 0.00590551181102362 2540 8688 26940,11957,68194,28080,17993,22229,66916,76826,69875,68493,67184,22228,22227,75406,110842 Ecsit,Atp5j,Ndufb4,Atp5o,Ndufs4,Ucp3,Ndufb7,Nubpl,Ndufa11,Ndufaf4,Ndufa13,Ucp2,Ucp1,Ndufs7,Etfa R-MMU-68874 M/G1 Transition 0.999518575054479 -0.000481540867716552 83 12 0.0047244094488189 2540 8688 59029,12545,17219,66997,66998,26443,18974,103554,13555,17463,13557,26440 Psmd14,Cdc7,Mcm6,Psmd12,Psmd5,Psma6,Pole2,Psme4,E2f1,Psmd7,E2f3,Psma1 R-MMU-69002 DNA Replication Pre-Initiation 0.999518575054479 -0.000481540867716552 83 12 0.0047244094488189 2540 8688 59029,12545,66997,66998,17219,26443,18974,103554,26440,17463,13557,13555 Psmd14,Cdc7,Psmd12,Psmd5,Mcm6,Psma6,Pole2,Psme4,Psma1,Psmd7,E2f3,E2f1 R-MMU-611105 Respiratory electron transport 0.999585131732979 -0.000414954348669974 74 10 0.00393700787401575 2540 8688 75406,110842,69875,68493,67184,76826,66916,68194,26940,17993 Ndufs7,Etfa,Ndufa11,Ndufaf4,Ndufa13,Nubpl,Ndufb7,Ndufb4,Ecsit,Ndufs4 R-MMU-72613 Eukaryotic Translation Initiation 0.999618754933747 -0.000381317758629271 112 18 0.00708661417322835 2540 8688 20088,14109,20090,66475,19921,57808,19946,68436,56040,67115,11837,19981,267019,68135,19944,67204,100042807,100502825 Rps24,Fau,Rps29,Rps23,Rpl19,Rpl35a,Rpl30,Rpl34,Rplp1,Rpl14,Rplp0,Rpl37a,Rps15a,Eif3h,Rpl29,Eif2s2,Eif3j2,Rpl37rt R-MMU-72737 Cap-dependent Translation Initiation 0.999618754933747 -0.000381317758629271 112 18 0.00708661417322835 2540 8688 19921,57808,66475,68436,67115,56040,19946,14109,20088,20090,19944,67204,100502825,100042807,19981,267019,11837,68135 Rpl19,Rpl35a,Rps23,Rpl34,Rpl14,Rplp1,Rpl30,Fau,Rps24,Rps29,Rpl29,Eif2s2,Rpl37rt,Eif3j2,Rpl37a,Rps15a,Rplp0,Eif3h R-MMU-5689603 UCH proteinases 0.999651314132817 -0.000348746672235119 94 14 0.00551181102362205 2540 8688 56505,225280,59029,50933,227195,66998,66997,26443,17425,93841,103554,12021,26440,17463 Ruvbl1,Ino80c,Psmd14,Uchl3,Ino80d,Psmd5,Psmd12,Psma6,Foxk1,Uchl4,Psme4,Bard1,Psma1,Psmd7 R-MMU-69304 Regulation of DNA replication 0.999669169060081 -0.000330885676546845 75 10 0.00393700787401575 2540 8688 59029,17219,66997,66998,26443,103554,13557,13555,17463,26440 Psmd14,Mcm6,Psmd12,Psmd5,Psma6,Psme4,E2f3,E2f1,Psmd7,Psma1 R-MMU-69206 G1/S Transition 0.999769125381365 -0.000230901274282229 110 17 0.00669291338582677 2540 8688 12447,66997,11651,17219,12443,17463,13555,27401,66998,12545,59029,17420,26440,18974,26443,22390,73699 Ccne1,Psmd12,Akt1,Mcm6,Ccnd1,Psmd7,E2f1,Skp2,Psmd5,Cdc7,Psmd14,Mnat1,Psma1,Pole2,Psma6,Wee1,Ppp2r1b R-MMU-69306 DNA Replication 0.999796864127667 -0.000203156507218636 106 16 0.0062992125984252 2540 8688 17219,66997,272551,19687,13555,17463,103554,69263,66998,12545,59029,13557,26440,18972,18974,26443 Mcm6,Psmd12,Gins2,Rfc1,E2f1,Psmd7,Psme4,Rfc3,Psmd5,Cdc7,Psmd14,E2f3,Psma1,Pold2,Pole2,Psma6 R-MMU-73857 RNA Polymerase II Transcription 0.99982165344198 -0.000178362463658296 143 24 0.0094488188976378 2540 8688 24116,99730,13716,72290,20643,54624,20383,17420,20924,70122,13871,18789,235497,83602,64340,72949,74197,66231,228980,71713,67655,73666,68776,66441 Nelfa,Taf13,Ell,Lsm11,Snrpe,Paf1,Srsf3,Mnat1,Supt5,Mllt3,Ercc2,Papola,Leo1,Gtf2a1,Dhx38,Ccnt2,Gtf2e1,Thoc7,Taf4,Cdc40,Ctdp1,Thoc3,Taf11,Magohb R-MMU-5334118 DNA methylation 0.999833849792184 -0.000166164012291135 78 10 0.00393700787401575 2540 8688 319177,13433,15078,97122,13435,97114,319161,15081,51788,26914 Hist1h2ba,Dnmt1,H3f3a,Hist2h4,Dnmt3a,Hist2h3c2,Hist1h4n,H3f3b,H2afz,H2afy R-MMU-5389840 Mitochondrial translation elongation 0.99983450463535 -0.000165509060519265 83 11 0.00433070866141732 2540 8688 67840,94062,64657,66845,121022,67270,68537,59054,64659,60441,66230 Mrpl57,Mrpl3,Mrps10,Mrpl33,Mrps6,Mrpl42,Mrpl13,Mrps30,Mrps14,Mrpl38,Mrps28 R-MMU-453279 Mitotic G1-G1/S phases 0.999887294799289 -0.00011271155241964 132 21 0.00826771653543307 2540 8688 13557,26440,13548,18974,73699,26443,22390,12571,66998,12545,59029,21973,17420,13555,17463,27401,11651,12443,17219,12447,66997 E2f3,Psma1,Dyrk1a,Pole2,Ppp2r1b,Psma6,Wee1,Cdk6,Psmd5,Cdc7,Psmd14,Top2a,Mnat1,E2f1,Psmd7,Skp2,Akt1,Ccnd1,Mcm6,Ccne1,Psmd12 R-MMU-211981 Xenobiotics 0.99989312389199 -0.000106881819668546 41 3 0.00118110236220472 2540 8688 11864,56448,11622 Arnt2,Cyp2d22,Ahr R-MMU-5419276 Mitochondrial translation termination 0.999895060567129 -0.000104944939398409 85 11 0.00433070866141732 2540 8688 67840,94062,64657,66845,121022,59054,68537,67270,64659,66230,60441 Mrpl57,Mrpl3,Mrps10,Mrpl33,Mrps6,Mrps30,Mrpl13,Mrpl42,Mrps14,Mrps28,Mrpl38 R-MMU-73854 RNA Polymerase I Promoter Clearance 0.999895823761466 -0.000104181665255614 80 10 0.00393700787401575 2540 8688 17420,20018,319955,97122,15078,319161,97114,15081,17191,13871 Mnat1,Polr1d,Ercc6,Hist2h4,H3f3a,Hist1h4n,Hist2h3c2,H3f3b,Mbd2,Ercc2 R-MMU-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.999896722093804 -0.00010328323972599 114 17 0.00669291338582677 2540 8688 70428,319161,97114,13871,15078,67486,20018,319955,66596,208595,15081,17191,78929,97122,98488,75627,17420 Polr3b,Hist1h4n,Hist2h3c2,Ercc2,H3f3a,Polr3g,Polr1d,Ercc6,Gtf3a,Mterf1b,H3f3b,Mbd2,Polr3h,Hist2h4,Gtf3c3,Snapc1,Mnat1 R-MMU-69052 Switching of origins to a post-replicative state 0.999903993635365 -9.60109735408496e-05 70 8 0.0031496062992126 2540 8688 26443,103554,26440,17463,59029,66997,66998,17219 Psma6,Psme4,Psma1,Psmd7,Psmd14,Psmd12,Psmd5,Mcm6 R-MMU-68949 Orc1 removal from chromatin 0.999903993635365 -9.60109735408496e-05 70 8 0.0031496062992126 2540 8688 17463,26440,103554,26443,17219,66997,66998,59029 Psmd7,Psma1,Psme4,Psma6,Mcm6,Psmd12,Psmd5,Psmd14 R-MMU-73762 RNA Polymerase I Transcription Initiation 0.99991434811155 -8.56555567828366e-05 48 4 0.0015748031496063 2540 8688 17420,20018,13871,319955 Mnat1,Polr1d,Ercc2,Ercc6 R-MMU-5368287 Mitochondrial translation 0.999916618288191 -8.33851882573384e-05 86 11 0.00433070866141732 2540 8688 66845,67840,94062,64657,60441,66230,121022,67270,59054,68537,64659 Mrpl33,Mrpl57,Mrpl3,Mrps10,Mrpl38,Mrps28,Mrps6,Mrpl42,Mrps30,Mrpl13,Mrps14 R-MMU-912497 Meiotic Recombination 0.999916970778861 -8.3032668255578e-05 91 12 0.0047244094488189 2540 8688 17350,15078,97122,319177,15081,12144,97114,319161,21975,51788,26972,26914 Mlh1,H3f3a,Hist2h4,Hist1h2ba,H3f3b,Blm,Hist2h3c2,Hist1h4n,Top3a,H2afz,Spo11,H2afy R-MMU-73864 RNA Polymerase I Transcription 0.999917690387558 -8.23130000636621e-05 81 10 0.00393700787401575 2540 8688 15081,97114,319161,13871,17191,15078,97122,319955,20018,17420 H3f3b,Hist2h3c2,Hist1h4n,Ercc2,Mbd2,H3f3a,Hist2h4,Ercc6,Polr1d,Mnat1 R-MMU-6803157 Antimicrobial peptides 0.999922866757211 -7.71362177105118e-05 60 6 0.00236220472440945 2540 8688 12652,329547,11927,22072,24088,21897 Chga,Bpi,Atox1,Prss2,Tlr2,Tlr1 R-MMU-69300 Removal of licensing factors from origins 0.99994174368363 -5.82580133349748e-05 72 8 0.0031496062992126 2540 8688 103554,26440,17463,26443,66998,66997,17219,59029 Psme4,Psma1,Psmd7,Psma6,Psmd5,Psmd12,Mcm6,Psmd14 R-MMU-5619507 Activation of HOX genes during differentiation 0.999943931219439 -5.6070352473714e-05 131 20 0.0078740157480315 2540 8688 15078,218772,319161,97114,17268,51788,15423,16658,17979,15401,19411,97122,319177,13654,18514,15081,16476,19401,26914,20181 H3f3a,Rarb,Hist1h4n,Hist2h3c2,Meis1,H2afz,Hoxc4,Mafb,Ncoa3,Hoxa4,Rarg,Hist2h4,Hist1h2ba,Egr2,Pbx1,H3f3b,Jun,Rara,H2afy,Rxra R-MMU-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0.999943931219439 -5.6070352473714e-05 131 20 0.0078740157480315 2540 8688 20181,26914,19401,16476,18514,15081,13654,319177,97122,19411,15401,17979,16658,51788,15423,17268,97114,319161,15078,218772 Rxra,H2afy,Rara,Jun,Pbx1,H3f3b,Egr2,Hist1h2ba,Hist2h4,Rarg,Hoxa4,Ncoa3,Mafb,H2afz,Hoxc4,Meis1,Hist2h3c2,Hist1h4n,H3f3a,Rarb R-MMU-69239 Synthesis of DNA 0.999947746733195 -5.22546320548042e-05 98 13 0.00511811023622047 2540 8688 26443,17463,26440,18972,18974,103554,59029,19687,17219,66998,69263,66997,272551 Psma6,Psmd7,Psma1,Pold2,Pole2,Psme4,Psmd14,Rfc1,Mcm6,Psmd5,Rfc3,Psmd12,Gins2 R-MMU-1500620 Meiosis 0.999957227225716 -4.27736890648045e-05 123 18 0.00708661417322835 2540 8688 319161,97114,64009,77053,223697,15078,19357,16905,26972,51788,15081,12144,319177,16906,97122,17350,26914,21975 Hist1h4n,Hist2h3c2,Syne1,Sun1,Sun2,H3f3a,Rad21,Lmna,Spo11,H2afz,H3f3b,Blm,Hist1h2ba,Lmnb1,Hist2h4,Mlh1,H2afy,Top3a R-MMU-1236975 Antigen processing-Cross presentation 0.999958248899607 -4.17519719945046e-05 99 13 0.00511811023622047 2540 8688 17970,59029,240028,66998,66997,16410,26443,16419,12491,103554,17969,26440,17463 Ncf2,Psmd14,Lnpep,Psmd5,Psmd12,Itgav,Psma6,Itgb5,Cd36,Psme4,Ncf1,Psma1,Psmd7 R-MMU-72163 mRNA Splicing - Major Pathway 0.999971935007273 -2.8065386556751e-05 171 28 0.0110236220472441 2540 8688 66441,71702,67465,66373,76522,68592,229279,15387,67678,68981,71713,74326,107686,64340,59013,68183,18789,50783,66070,67439,67285,20383,78651,15481,20639,66642,20643,80744 Magohb,Cdc5l,Sf3a1,Lsm5,Lsm8,Syf2,Hnrnpa3,Hnrnpk,Lsm3,Snrpa1,Cdc40,Hnrnpr,Snrpd2,Dhx38,Hnrnph1,Bcas2,Papola,Lsm4,Cwc15,Xab2,Cwc27,Srsf3,Lsm6,Hspa8,Snrpb2,Ctnnbl1,Snrpe,Cwc22 R-MMU-72172 mRNA Splicing 0.999972358293188 -2.76420888513871e-05 180 30 0.0118110236220472 2540 8688 66642,67225,80744,20643,67285,20383,15481,20639,78651,107686,74326,71713,18789,68183,67439,66070,50783,59013,64340,67465,66373,66441,71702,68981,22184,67678,68592,229279,76522,15387 Ctnnbl1,Rnpc3,Cwc22,Snrpe,Cwc27,Srsf3,Hspa8,Snrpb2,Lsm6,Snrpd2,Hnrnpr,Cdc40,Papola,Bcas2,Xab2,Cwc15,Lsm4,Hnrnph1,Dhx38,Sf3a1,Lsm5,Magohb,Cdc5l,Snrpa1,Zrsr2,Lsm3,Syf2,Hnrnpa3,Lsm8,Hnrnpk R-MMU-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.999972743215912 -2.72571555611792e-05 75 8 0.0031496062992126 2540 8688 15078,97122,319177,97114,15081,319161,51788,26914 H3f3a,Hist2h4,Hist1h2ba,Hist2h3c2,H3f3b,Hist1h4n,H2afz,H2afy R-MMU-1221632 Meiotic synapsis 0.999973688301395 -2.631204476408e-05 106 14 0.00551181102362205 2540 8688 51788,26914,16905,19357,223697,97122,15078,319177,16906,77053,64009,97114,319161,15081 H2afz,H2afy,Lmna,Rad21,Sun2,Hist2h4,H3f3a,Hist1h2ba,Lmnb1,Sun1,Syne1,Hist2h3c2,Hist1h4n,H3f3b R-MMU-1221633 Meiotic Synapsis 0.999973688301395 -2.631204476408e-05 106 14 0.00551181102362205 2540 8688 64009,77053,319161,15081,97114,223697,15078,97122,319177,16906,16905,26914,19357,51788 Syne1,Sun1,Hist1h4n,H3f3b,Hist2h3c2,Sun2,H3f3a,Hist2h4,Hist1h2ba,Lmnb1,Lmna,H2afy,Rad21,H2afz R-MMU-427413 NoRC negatively regulates rRNA expression 0.999979607599755 -2.03926081728942e-05 92 11 0.00433070866141732 2540 8688 97114,319161,15081,17191,13433,319177,97122,15078,20018,26914,51788 Hist2h3c2,Hist1h4n,H3f3b,Mbd2,Dnmt1,Hist1h2ba,Hist2h4,H3f3a,Polr1d,H2afy,H2afz R-MMU-72165 mRNA Splicing - Minor Pathway 0.999988855702953 -1.1144359145562e-05 55 4 0.0015748031496063 2540 8688 107686,67225,22184,20643 Snrpd2,Rnpc3,Zrsr2,Snrpe R-MMU-211000 Gene Silencing by RNA 0.999989419374413 -1.05806815623026e-05 105 13 0.00511811023622047 2540 8688 15078,97122,213988,239528,227720,192119,19069,15081,319161,97114,71805,233833,218210 H3f3a,Hist2h4,Tnrc6b,Ago2,Nup214,Dicer1,Nup88,H3f3b,Hist1h4n,Hist2h3c2,Nup93,Tnrc6a,Nup153 R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.999990688154742 -9.31188861378163e-06 49 3 0.00118110236220472 2540 8688 20334,110379,69608 Sec23a,Sec13,Sec24d R-MMU-1640170 Cell Cycle 0.999990801948246 -9.19809405656944e-06 596 130 0.0511811023622047 2540 8688 244329,67956,66578,73699,244495,18974,107976,225182,17248,77744,18750,434233,103554,64009,70315,16563,227613,214444,17120,17246,329251,14245,319177,56150,18751,12234,26440,56505,108000,17535,448987,66997,101706,66977,227720,15516,16319,70620,17420,19088,69263,27223,16906,99412,71175,22059,83431,16905,56430,17463,13555,97114,320595,27373,12545,56317,13557,13548,19356,245474,218210,59126,229776,272551,11651,21664,319161,21975,18472,12237,107995,26932,26443,22630,18972,67121,22628,67629,12021,15081,71805,51788,223697,26951,22631,13191,21973,110379,26914,15574,217718,18005,100710,226747,19687,51885,26972,103583,56438,12447,15078,27401,71648,66311,76499,56637,208628,12571,66998,97122,59021,22390,73738,12144,226849,223970,76707,12617,13000,59029,22194,17350,22367,19069,72415,17219,99100,12443,19357,77053 Mcph1,Kmt5a,Mis18a,Ppp2r1b,Sgo2b,Pole2,Babam2,Rbbp8,Mdm4,Bora,Prkca,Ppp1ccb,Psme4,Syne1,Hdac8,Kif2a,Tubb4b,Cdk5rap2,Mad1l1,Mdm2,Ppp1r12b,Lpin1,Hist1h2ba,Mad2l1,Prkcb,Btrc,Psma1,Ruvbl1,Cenpf,Mre11a,Fbxl7,Psmd12,Numa1,Nuf2,Nup214,Hsp90ab1,Incenp,Ube2v2,Mnat1,Prkar2b,Rfc3,Trp53bp1,Lmnb1,Golga2,Nipbl,Trp53,Ndel1,Lmna,Clip1,Psmd7,E2f1,Hist2h3c2,Phf8,Csnk1e,Cdc7,Anapc7,E2f3,Dyrk1a,Rad17,Dkc1,Nup153,Nek6,Cdc14a,Gins2,Akt1,Phlda1,Hist1h4n,Top3a,Pafah1b1,Bub3,Cdc20,Ppp2r5e,Psma6,Ywhaq,Pold2,Mastl,Ywhag,Spc24,Bard1,H3f3b,Nup93,H2afz,Sun2,Zw10,Ywhaz,Dctn1,Top2a,Sec13,H2afy,Hus1,Nek9,Nek2,Pds5b,Ahctf1,Rfc1,Tubgcp4,Spo11,Fbxw11,Rbx1,Ccne1,H3f3a,Skp2,Optn,Cenpw,Clasp2,Gsk3b,Kntc1,Cdk6,Psmd5,Hist2h4,Rab2a,Wee1,Haus7,Blm,Ppp2r5a,Rmi2,Clasp1,Cenpc1,Csnk2a2,Psmd14,Ube2e1,Mlh1,Vrk1,Nup88,Sgo1,Mcm6,Cep152,Ccnd1,Rad21,Sun1 R-MMU-1236977 Endosomal/Vacuolar pathway 0.999992378284162 -7.62174488388055e-06 34 1 0.000393700787401575 2540 8688 240028 Lnpep R-MMU-573389 NoRC negatively regulates rRNA expression 0.999992745856776 -7.25416953556251e-06 91 10 0.00393700787401575 2540 8688 51788,20018,26914,15078,97122,13433,319177,15081,97114,319161 H2afz,Polr1d,H2afy,H3f3a,Hist2h4,Dnmt1,Hist1h2ba,H3f3b,Hist2h3c2,Hist1h4n R-MMU-6805567 Keratinization 0.999997005099835 -2.99490464954826e-06 150 21 0.00826771653543307 2540 8688 16480,12336,18550,75706,13505,18553,16660,109620,19143,76560,16693,13512,67451,13511,69664,406221,71529,16665,16666,18772,114566 Jup,Capns1,Furin,Krt24,Dsc1,Pcsk6,Krt31,Dsp,St14,Prss8,Krtap11-1,Dsg3,Pkp2,Dsg2,Krtap1-5,Krt40,Kazn,Krt15,Krt16,Pkp1,Krt82 R-MMU-5250941 Negative epigenetic regulation of rRNA expression 0.999997088219507 -2.91178473207751e-06 100 11 0.00433070866141732 2540 8688 97122,15078,319177,13433,17191,15081,319161,97114,51788,20018,26914 Hist2h4,H3f3a,Hist1h2ba,Dnmt1,Mbd2,H3f3b,Hist1h4n,Hist2h3c2,H2afz,Polr1d,H2afy R-MMU-212165 Epigenetic regulation of gene expression 0.999998288211446 -1.7117900194412e-06 138 18 0.00708661417322835 2540 8688 20018,319955,51788,11569,97114,319161,13435,15078,13433,26914,56637,214133,17913,17191,15081,52463,97122,319177 Polr1d,Ercc6,H2afz,Aebp2,Hist2h3c2,Hist1h4n,Dnmt3a,H3f3a,Dnmt1,H2afy,Gsk3b,Tet2,Myo1c,Mbd2,H3f3b,Tet1,Hist2h4,Hist1h2ba R-MMU-5250913 Positive epigenetic regulation of rRNA expression 0.999998502952754 -1.49704836635391e-06 108 12 0.0047244094488189 2540 8688 319161,97114,15081,17913,319177,15078,97122,20018,319955,26914,51788,56637 Hist1h4n,Hist2h3c2,H3f3b,Myo1c,Hist1h2ba,H3f3a,Hist2h4,Polr1d,Ercc6,H2afy,H2afz,Gsk3b R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.99999901967185 -9.80328630664601e-07 115 13 0.00511811023622047 2540 8688 74603,17059,16401,80782,16414,16412,16415,74482,243864,19294,68713,71326,271375 Cd200r3,Klrb1c,Itga4,Klrb1b,Itgb2,Itgb1,Itgb2l,Ifitm7,Mill2,Nectin2,Ifitm1,Treml1,Cd200r2 R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA 0.999999244439703 -7.55560582439819e-07 231 37 0.0145669291338583 2540 8688 20383,15481,78651,66642,67225,67465,71805,71702,76522,66231,64340,67285,20639,80744,19069,20643,73666,66373,66441,218210,68981,67678,22184,229279,68592,15387,107686,74326,56488,71713,227720,68183,18789,66070,67439,50783,59013 Srsf3,Hspa8,Lsm6,Ctnnbl1,Rnpc3,Sf3a1,Nup93,Cdc5l,Lsm8,Thoc7,Dhx38,Cwc27,Snrpb2,Cwc22,Nup88,Snrpe,Thoc3,Lsm5,Magohb,Nup153,Snrpa1,Lsm3,Zrsr2,Hnrnpa3,Syf2,Hnrnpk,Snrpd2,Hnrnpr,Nxt1,Cdc40,Nup214,Bcas2,Papola,Cwc15,Xab2,Lsm4,Hnrnph1 R-MMU-74160 Gene Expression 0.999999997345018 -2.65498178676297e-09 1163 258 0.101574803149606 2540 8688 19744,78651,63856,21975,20383,22628,17191,67225,12021,22337,20393,69181,26443,17131,227743,67465,71805,67204,74370,51788,218333,66096,22631,21815,19921,69790,26423,21676,52830,15574,18129,229279,12447,192657,21981,66313,59013,20620,21834,56488,228980,15481,66998,17126,18128,70122,12144,106931,14109,26992,76522,110532,433586,13435,319801,216987,13000,69260,214133,108099,13865,192119,19704,68576,15507,13982,69305,70640,67956,14852,225182,100042807,17248,73674,57748,103554,11835,104625,20181,641340,20813,22084,26440,66446,17246,21679,66997,73666,83602,50783,213895,107686,72949,14815,14791,26416,67276,217337,66475,78929,213988,20018,319955,71702,68979,13871,70428,97114,26381,13433,67115,12192,20481,233833,57316,68106,68981,11651,67486,14536,208595,66373,218210,67439,68135,218772,267019,17684,225998,226830,22630,24116,76130,15081,72290,56422,66596,327987,15258,67768,17164,26914,20639,80744,67678,68592,70088,22166,66441,20602,68183,66070,15078,71713,22061,28077,19946,50911,237221,56637,11737,17913,99730,19664,66642,97122,239528,20088,15511,19411,223970,18130,215193,19944,13197,94112,18997,235497,74747,66231,56417,54624,21388,67285,59029,75627,101861,19069,26424,67381,12905,72587,15387,68776,18789,67755,16009,57808,234374,19401,13716,22025,73699,100502825,18750,77976,64340,74197,17127,26399,12393,11545,319177,72068,18718,264064,18753,97064,17535,228829,11569,18667,74326,19981,18132,270118,227720,11837,56040,68436,19883,98488,69263,68428,27058,17420,20090,18607,68975,53975,108079,22059,17463,14782,231464,67895,20924,50912,80707,52463,19356,20643,15378,67655,22184,209456,319161,12177 Rheb,Lsm6,Taf8,Top3a,Srsf3,Ywhag,Mbd2,Rnpc3,Bard1,Vdr,Sgk1,Dyrk2,Psma6,Smad7,Mapkap1,Sf3a1,Nup93,Eif2s2,Rptor,H2afz,Ice1,Lamtor4,Ywhaz,Tgif1,Rpl19,Med30,Nr5a1,Tead1,Pnrc2,Hus1,Notch2,Hnrnpa3,Ccne1,Ell2,Ppp1r13b,Smurf2,Hnrnph1,Plk2,Thrb,Nxt1,Taf4,Hspa8,Psmd5,Smad2,Notch1,Mllt3,Blm,Kctd1,Fau,Brd7,Lsm8,Adarb1,Maml3,Dnmt3a,Tigar,Utp6,Csnk2a2,Ing2,Tet2,Prkag2,Nr2f1,Dicer1,Upf1,Lamtor5,Hspb1,Esr1,Dcps,Dcp2,Kmt5a,Gspt1,Rbbp8,Eif3j2,Mdm4,Wdr75,Jmy,Psme4,Ar,Cnot6,Rxra,Nrbf2,Srp14,Tsc2,Psma1,Exosc7,Mdm2,Tead4,Psmd12,Thoc3,Gtf2a1,Lsm4,Bms1,Snrpd2,Ccnt2,Nr3c1,Emg1,Mapk14,Eri1,Srp68,Rps23,Polr3h,Tnrc6b,Polr1d,Ercc6,Cdc5l,Nol11,Ercc2,Polr3b,Hist2h3c2,Esrrg,Dnmt1,Rpl14,Zfp36l1,Ski,Tnrc6a,C1d,Nt5c3b,Snrpa1,Akt1,Polr3g,Nr6a1,Mterf1b,Lsm5,Nup153,Xab2,Eif3h,Rarb,Rps15a,Cited2,Rorb,Smyd2,Ywhaq,Nelfa,Las1l,H3f3b,Lsm11,Hbs1l,Gtf3a,Med13,Hipk2,N6amt1,Mapkapk2,H2afy,Snrpb2,Cwc22,Lsm3,Syf2,Meaf6,Txn1,Magohb,Ncor2,Bcas2,Cwc15,H3f3a,Cdc40,Trp63,Med10,Rpl30,Exosc9,Gemin8,Gsk3b,Anp32a,Myo1c,Taf13,Rbpj,Ctnnbl1,Hist2h4,Ago2,Rps24,Hspa1b,Rarg,Rmi2,Ints6,Utp25,Rpl29,Gadd45a,Med15,Pou4f2,Leo1,Ddit4,Thoc7,Adar,Paf1,Tbx5,Cwc27,Psmd14,Snapc1,Ints4,Nup88,Nr5a2,Med4,Cradd,Pan3,Hnrnpk,Taf11,Papola,Ddx47,Igfbp3,Rpl35a,Ddx49,Rara,Ell,Nr2c1,Ppp2r1b,Rpl37rt,Prkca,Nuak1,Dhx38,Gtf2e1,Smad3,Map2k6,Runx2,Parp1,Hist1h2ba,Cnot2,Pip4k2a,Cdk8,Prkcd,Wwtr1,Mre11a,Phf20,Aebp2,Pgr,Hnrnpr,Rpl37a,Notch4,Maml2,Nup214,Rplp0,Rplp1,Rpl34,Rora,Gtf3c3,Rfc3,Steap3,Srp9,Mnat1,Rps29,Pdpk1,Med27,Ddx20,Prkaa2,Trp53,Psmd7,Gsr,Cnot6l,Ppa1,Supt5,Exosc10,Wwox,Tet1,Rad17,Snrpe,Hnf4a,Ctdp1,Zrsr2,Trp53bp2,Hist1h4n,Bnip3l R-MMU-372790 Signaling by GPCR 0.999999999820357 -1.79643065342193e-10 1331 292 0.11496062992126 2540 8688 171530,17200,24001,17463,12984,12776,14360,12313,11516,11551,18442,19414,57257,18015,18706,26364,70839,16185,13649,18607,12778,11553,18708,258408,19227,18590,240168,14709,13616,74769,12424,16367,14773,15199,24111,18755,212541,14083,14184,11852,18578,110197,71111,16800,73341,19085,14172,13605,50780,57254,18574,14710,18750,56696,15550,54611,20608,11542,14682,545156,14675,73699,18322,258922,258153,18753,102098,30878,19065,17329,20315,69601,80910,18346,54393,64214,16438,235611,19735,226849,238871,74191,14701,23945,65086,30938,269060,230857,226278,11876,18441,14677,12767,18430,20112,380921,16801,56066,224129,18783,217674,258198,59029,19228,319229,12223,240672,227717,22045,14652,12326,114715,14163,71704,12671,11535,622434,237362,269608,22065,14744,18673,258830,56349,83770,16443,140498,20742,16440,239283,67603,21844,16439,15200,235584,16183,15461,381413,432530,109934,14526,52250,258330,213649,18619,52666,14683,19204,14708,110157,80901,18575,14693,11513,239530,54126,12062,11548,12981,108058,18761,227333,19084,19088,12323,16452,13618,67839,18754,19419,11651,68338,15552,239766,53972,100042150,51801,13614,16451,258151,12374,58182,16453,242093,14183,14767,242425,13617,12061,230972,277360,54409,16591,78134,83961,54153,14186,103554,14702,14816,384783,171469,109648,13615,13610,14063,54324,19262,210044,66997,12919,84112,104418,12801,208188,380698,18795,26946,14182,15234,258426,140795,26440,20418,15557,13385,12314,217480,20662,75547,23984,14607,218397,66998,14745,387347,11606,13869,18798,11549,320127,14573,14180,15559,19353,50501,15465,20779,18573,14811,237880,14173,100043507,14062,218461,231474,12775,11554,19220,225192,13609,14527,216749,14696,252837,18217,224014,18166,29863,207212,26443,26932,213498,243407,56438,14678,18583,17295,54199,20297,11515,18584,223435,12922,233571,11820,56183,20111,104111,319239,80903,17967 Ucn2,Mc2r,Tiam2,Psmd7,Csf2rb2,Ccr8,Fyn,Calm1,Adcyap1,Adra2a,P2ry2,Rasa3,Vav3,Nf1,Pik3ca,Adgre5,P2ry12,Il2rb,Egfr,Pdpk1,Ackr3,Adra2c,Pik3r1,Olfr463,Pthlh,Pdgfa,Rasgrp3,Gng8,Edn3,Pik3cb,Cck,Irs1,Grk5,Hebp1,Uts2,Prkch,Rho,Ptk2,Fgfr3,Rhob,Pde4b,Dgkg,Gpr39,Arhgef2,Arhgef6,Prkar1b,Fgf18,Ect2,Rgs3,Tas2r119,Pde1b,Gngt2,Prkca,Gpr132,Htr1a,Pde3a,Sstr4,Adora3,Gnaq,Kalrn,Gna14,Ppp2r1b,Olfr24,Olfr267,Olfr412,Prkcd,Arhgef18,Apln,Npy4r,Cxcl9,Cxcl12,Dab2ip,Gpr84,Olfr47,Gabbr1,Rgs18,Itpr1,Plxnb1,Rgs2,Ppp2r5a,Pde4d,P2ry13,Gng12,Mgll,Lpar3,Fgd3,Dagla,Ece1,Prlhr,Artn,P2ry1,Gnai1,Cxcr4,Oxtr,Rps6ka2,Dgkh,Arhgef1,Cxcl11,Adcy5,Pla2g4a,Gphb5,Olfr224,Psmd14,Pth1r,Sctr,Btc,Dusp5,Qrfp,Trhr,Glp1r,Camk4,Spred1,Fgd1,Arhgef3,Chrm3,Adm,Arhgef26,Npffr1,Plekhg5,Trpc3,Gpr65,Phb,Olfr103,Net1,Tas1r2,Itsn1,Rxfp2,Sptbn1,Itpr3,Oxgr1,Dusp6,Tiam1,Itpr2,Hbegf,Dusp7,Il2,Hras,Gpr176,Adcy1,Abr,Gcg,Reep1,Olfr1274-ps,Arhgef19,Penk,Arhgef25,Gnas,Ptafr,Gng7,Raf1,Cxcr6,Pde1c,Gnb2,Adcy7,Gpr20,Arhgef7,Bdkrb2,Adra1b,Csf2,Camk2d,Prkcq,Dgkd,Prkar1a,Prkar2b,Camk2b,Jak2,Ednrb,Gpsm1,Prkce,Rasgrp1,Akt1,Golt1a,Htr1d,Rtp1,Ngef,Nrg2,Ramp1,Edn1,Jak1,Olfr1505,Casr,Prokr1,Jak3,Rxfp4,Fgfr2,Nmur1,Gabbr2,Ednra,Bdkrb1,Arhgef16,Prex1,Ramp2,Kl,Lpar4,Nrg4,Rasa4,Fgfr4,Psme4,Gng2,Grm1,Irs2,Gpr37l1,Npy,Edn2,S1pr3,F2rl1,Arhgef5,Ptpra,Adcy2,Psmd12,Crhbp,Sucnr1,Dgkz,Cnr1,Ghsr,Obscn,Plcb1,Trpc7,Fgfr1,Hgf,Olfr995,P2ry14,Psma1,Shc3,Htr1f,Dlg4,Calm2,Dgkb,Sos1,Akap13,Pde10a,Gip,Rasa1,Psmd5,Lpar1,Tas2r118,Agt,Erbb4,Plcb4,Adra1a,Dgki,Gdnf,Fgf9,Htr2b,Rac1,Prok2,Hrh1,Src,Pde1a,Grin2a,1700071K01Rik,Fgf2,Gng5-ps,F2r,Pde8b,Paqr3,Ccr7,Adrb1,Ptgfr,Hrh4,S1pr1,Gcgr,Nmur2,Gnb4,Ackr4,Ntsr2,Fgd4,Npy1r,Pde7b,Arhgef17,Psma6,Ppp2r5e,Arhgef11,Qrfprl,Rbx1,Gnai2,Pde7a,Met,Ccrl2,Ccl20,Adcy9,Pde8a,Trio,Crhr2,P2ry6,App,Nmu,Rps6ka1,Adcy3,Npsr1,Fgf16,Ncam1 R-MMU-388396 GPCR downstream signaling 0.999999999858115 -1.41885170798957e-10 1065 204 0.0803149606299213 2540 8688 140795,258426,64214,54393,80910,18346,18753,102098,84112,104418,258153,20315,26946,18795,17329,208188,380698,12801,30878,19065,13615,20608,109648,54611,210044,18322,258922,54324,14675,14063,13610,545156,14682,11542,13605,50780,78134,73341,15550,14702,14816,56696,18574,57254,12061,212541,242425,15199,18755,24111,13617,14767,14773,16453,242093,16800,277360,18578,110197,54409,11852,230972,239766,258408,19227,11651,68338,15552,74769,12374,58182,12424,16451,258151,51801,13614,53972,13616,70839,16452,16185,18706,18761,57257,227333,11551,18442,18754,18708,67839,11553,13618,18607,12778,17200,11516,12981,11548,11513,239530,54126,12062,24001,12984,80901,12776,319239,104111,52250,56183,11820,14683,19204,18619,52666,258330,213649,223435,16439,12922,21844,18584,14678,18583,11515,20297,239283,109934,14526,233571,381413,432530,16183,224014,22065,18217,140498,243407,213498,16440,56349,16443,207212,258830,14744,18166,29863,71704,225192,14163,12671,19220,11554,14652,12775,22045,269608,216749,14527,237362,13609,11535,622434,319229,258198,19228,217674,18573,227717,218461,14062,15559,19353,320127,224129,15465,50501,12767,18430,11606,14677,18441,387347,14745,56066,380921,16801,11549,18798,75547,235611,20662,19735,238871,16438,217480,15557,269060,30938,23984,14607,23945,65086,74191 P2ry14,Olfr995,Rgs18,Gabbr1,Gpr84,Olfr47,Prkcd,Arhgef18,Sucnr1,Dgkz,Olfr412,Cxcl12,Trpc7,Plcb1,Cxcl9,Ghsr,Obscn,Cnr1,Apln,Npy4r,Edn2,Sstr4,Npy,Pde3a,Adcy2,Olfr24,Olfr267,Arhgef5,Gna14,F2rl1,S1pr3,Kalrn,Gnaq,Adora3,Ect2,Rgs3,Lpar4,Arhgef6,Htr1a,Gng2,Grm1,Gpr132,Pde1b,Tas2r119,Bdkrb1,Rho,Gabbr2,Hebp1,Prkch,Uts2,Ednra,Nmur1,Grk5,Jak3,Rxfp4,Arhgef2,Prex1,Pde4b,Dgkg,Ramp2,Rhob,Arhgef16,Rtp1,Olfr463,Pthlh,Akt1,Golt1a,Htr1d,Pik3cb,Casr,Prokr1,Cck,Jak1,Olfr1505,Ramp1,Edn1,Ngef,Edn3,P2ry12,Jak2,Il2rb,Pik3ca,Prkcq,Vav3,Dgkd,Adra2a,P2ry2,Prkce,Pik3r1,Gpsm1,Adra2c,Ednrb,Pdpk1,Ackr3,Mc2r,Adcyap1,Csf2,Adra1b,Adcy7,Gpr20,Arhgef7,Bdkrb2,Tiam2,Csf2rb2,Cxcr6,Ccr8,Npsr1,Adcy3,Reep1,Nmu,App,Gnas,Ptafr,Penk,Arhgef25,Olfr1274-ps,Arhgef19,Trio,Itpr2,Crhr2,Tiam1,Pde8a,Gnai2,Pde7a,Adcy9,Ccl20,Oxgr1,Abr,Gcg,P2ry6,Gpr176,Adcy1,Il2,Fgd4,Trpc3,Ntsr2,Rxfp2,Qrfprl,Arhgef11,Itpr3,Net1,Itsn1,Arhgef17,Olfr103,Gpr65,Npy1r,Pde7b,Arhgef3,Hrh4,Fgd1,Chrm3,Ptgfr,Adrb1,Glp1r,Ccr7,Trhr,Plekhg5,Nmur2,Gcgr,Npffr1,S1pr1,Adm,Arhgef26,Sctr,Olfr224,Pth1r,Gphb5,Pde1a,Qrfp,Pde8b,F2r,Htr2b,Rac1,Dgki,Adcy5,Hrh1,Prok2,Cxcr4,Oxtr,Agt,Gnai1,P2ry1,Tas2r118,Lpar1,Cxcl11,Dgkh,Arhgef1,Adra1a,Plcb4,Akap13,Plxnb1,Sos1,Rgs2,Pde4d,Itpr1,Dgkb,Htr1f,Dagla,Fgd3,Pde10a,Gip,Mgll,Lpar3,P2ry13 R-MMU-381753 Olfactory Signaling Pathway 0.999999999898229 -1.01771489694361e-10 535 12 0.0047244094488189 2540 8688 18346,258830,258330,258151,258922,18322,258408,258153,52250,239766,258198,258426 Olfr47,Olfr103,Olfr1274-ps,Olfr1505,Olfr267,Olfr24,Olfr463,Olfr412,Reep1,Rtp1,Olfr224,Olfr995