TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-MMU-6783310 Fanconi Anemia Pathway 0.902799522701397 -0.102254762725874 33 5 0.00251509054325956 1988 8688 67196,67030,14088,330554,13870 Ube2t,Fancl,Fancc,Fan1,Ercc1 R-MMU-3270619 IRF3-mediated induction of type I IFN 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 207521 Dtx4 R-MMU-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 108043 Chrnb3 R-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 59021 Rab2a R-MMU-391908 Prostanoid ligand receptors 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 19220 Ptgfr R-MMU-174403 Glutathione synthesis and recycling 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 68044 Chac2 R-MMU-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 16150 Ikbkb R-MMU-937039 IRAK1 recruits IKK complex 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 16150 Ikbkb R-MMU-937042 IRAK2 mediated activation of TAK1 complex 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 26409 Map3k7 R-MMU-429947 Deadenylation of mRNA 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 72587 Pan3 R-MMU-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 73699 Ppp2r1b R-MMU-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.903648039906403 -0.101315330787772 9 1 0.000503018108651912 1988 8688 26409 Map3k7 R-MMU-1169091 Activation of NF-kappaB in B cells 0.906358738314709 -0.0983200929052443 65 11 0.00553319919517103 1988 8688 26443,103583,19696,18033,12042,108723,18035,16150,66998,17463,26440 Psma6,Fbxw11,Rel,Nfkb1,Bcl10,Card11,Nfkbia,Ikbkb,Psmd5,Psmd7,Psma1 R-MMU-1474165 Reproduction 0.908558917644306 -0.0958955416864304 22 3 0.00150905432595573 1988 8688 71078,12527,76718 Adam30,Cd9,Catsperg2 R-MMU-69273 Cyclin A/B1 associated events during G2/M transition 0.908558917644306 -0.0958955416864304 22 3 0.00150905432595573 1988 8688 73699,22390,17420 Ppp2r1b,Wee1,Mnat1 R-MMU-1614635 Sulfur amino acid metabolism 0.908558917644306 -0.0958955416864304 22 3 0.00150905432595573 1988 8688 66071,66902,12116 Ethe1,Mtap,Bhmt R-MMU-1187000 Fertilization 0.908558917644306 -0.0958955416864304 22 3 0.00150905432595573 1988 8688 12527,76718,71078 Cd9,Catsperg2,Adam30 R-MMU-5655862 Translesion synthesis by POLK 0.910261688337558 -0.0940231512097417 16 2 0.00100603621730382 1988 8688 27015,69263 Polk,Rfc3 R-MMU-166663 Initial triggering of complement 0.910261688337558 -0.0940231512097417 16 2 0.00100603621730382 1988 8688 11537,239447 Cfd,Colec10 R-MMU-936440 Negative regulators of RIG-I/MDA5 signaling 0.910261688337558 -0.0940231512097417 16 2 0.00100603621730382 1988 8688 74256,52440 Cyld,Tax1bp1 R-MMU-389948 PD-1 signaling 0.910261688337558 -0.0940231512097417 16 2 0.00100603621730382 1988 8688 14961,18566 H2-Ab1,Pdcd1 R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA 0.910261688337558 -0.0940231512097417 16 2 0.00100603621730382 1988 8688 207521,69807 Dtx4,Trim32 R-MMU-162710 Synthesis of glycosylphosphatidylinositol (GPI) 0.910261688337558 -0.0940231512097417 16 2 0.00100603621730382 1988 8688 27392,230801 Pign,Pigv R-MMU-5689896 Ovarian tumor domain proteases 0.911612461253995 -0.0925403120528792 28 4 0.00201207243460765 1988 8688 107607,19211,229603,13982 Nod1,Pten,Otud7b,Esr1 R-MMU-68877 Mitotic Prometaphase 0.913166225963999 -0.0908373492811292 111 20 0.0100603621730382 1988 8688 12237,26932,76499,73699,226747,16319,26951,67629,226849,434233,19357,83431,17120,108000,244495,56430,16563,100710,76707,56150 Bub3,Ppp2r5e,Clasp2,Ppp2r1b,Ahctf1,Incenp,Zw10,Spc24,Ppp2r5a,Ppp1ccb,Rad21,Ndel1,Mad1l1,Cenpf,Sgo2b,Clip1,Kif2a,Pds5b,Clasp1,Mad2l1 R-MMU-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 0.91649105051505 -0.0872029765999717 34 5 0.00251509054325956 1988 8688 217365,27015,216835,69263,18972 Nploc4,Polk,Usp43,Rfc3,Pold2 R-MMU-113418 Formation of the Early Elongation Complex 0.91649105051505 -0.0872029765999717 34 5 0.00251509054325956 1988 8688 67655,17420,13871,24116,20924 Ctdp1,Mnat1,Ercc2,Nelfa,Supt5 R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.917034094636867 -0.0866106267877736 45 7 0.00352112676056338 1988 8688 72949,20924,13871,24116,17420,13716,67655 Ccnt2,Supt5,Ercc2,Nelfa,Mnat1,Ell,Ctdp1 R-MMU-166208 mTORC1-mediated signalling 0.923865418626397 -0.0791888687857984 23 3 0.00150905432595573 1988 8688 74370,68576,19744 Rptor,Lamtor5,Rheb R-MMU-381038 XBP1(S) activates chaperone genes 0.925718289562787 -0.0771853135554971 10 1 0.000503018108651912 1988 8688 66212 Sec61b R-MMU-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.925718289562787 -0.0771853135554971 10 1 0.000503018108651912 1988 8688 18972 Pold2 R-MMU-174437 Removal of the Flap Intermediate from the C-strand 0.925718289562787 -0.0771853135554971 10 1 0.000503018108651912 1988 8688 18972 Pold2 R-MMU-1834941 STING mediated induction of host immune responses 0.925718289562787 -0.0771853135554971 10 1 0.000503018108651912 1988 8688 207521 Dtx4 R-MMU-1300642 Sperm Motility And Taxes 0.925718289562787 -0.0771853135554971 10 1 0.000503018108651912 1988 8688 76718 Catsperg2 R-MMU-196757 Metabolism of folate and pterines 0.927252381445419 -0.0755294943273345 17 2 0.00100603621730382 1988 8688 20509,270685 Slc19a1,Mthfd1l R-MMU-1480926 O2/CO2 exchange in erythrocytes 0.927252381445419 -0.0755294943273345 17 2 0.00100603621730382 1988 8688 11826,320635 Aqp1,Cyb5r2 R-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.927252381445419 -0.0755294943273345 17 2 0.00100603621730382 1988 8688 11826,320635 Aqp1,Cyb5r2 R-MMU-199977 ER to Golgi Anterograde Transport 0.927672069228326 -0.0750769823235 118 21 0.0105633802816901 1988 8688 56494,56358,64138,20334,21787,56395,67542,13191,11735,77038,67857,89867,72978,20742,22428,14799,16333,69608,13032,109676,105522 Gosr2,Copz2,Ctsz,Sec23a,Tfg,Tmem115,Cog6,Dctn1,Ank3,Arfgap2,Ppp6c,Sec16b,Cnih3,Sptbn1,Dctn6,Gria1,Ins1,Sec24d,Ctsc,Ank2,Ankrd28 R-MMU-3108232 SUMO E3 ligases SUMOylate target proteins 0.92821863649678 -0.0744879742719269 93 16 0.00804828973843058 1988 8688 68501,19357,226026,11545,218210,21969,27223,12144,17342,66341,20610,71805,19069,54383,15387,16319 Nsmce2,Rad21,Smc5,Parp1,Nup153,Top1,Trp53bp1,Blm,Mitf,Eid3,Sumo3,Nup93,Nup88,Phc2,Hnrnpk,Incenp R-MMU-5696394 DNA Damage Recognition in GG-NER 0.928452494914519 -0.0742360627567219 35 5 0.00251509054325956 1988 8688 225280,108679,11545,19359,227195 Ino80c,Cops8,Parp1,Rad23b,Ino80d R-MMU-5625740 RHO GTPases activate PKNs 0.933121208344237 -0.0692201740922637 52 8 0.00402414486921529 1988 8688 15078,99982,22630,18607,68458,22628,11852,22631 H3f3a,Kdm1a,Ywhaq,Pdpk1,Ppp1r14a,Ywhag,Rhob,Ywhaz R-MMU-2990846 SUMOylation 0.934625903720509 -0.0676089327287179 99 17 0.0085513078470825 1988 8688 16319,54383,15387,71805,19069,17342,20610,66341,27223,12144,11545,218210,21969,19357,226026,66568,68501 Incenp,Phc2,Hnrnpk,Nup93,Nup88,Mitf,Sumo3,Eid3,Trp53bp1,Blm,Parp1,Nup153,Top1,Rad21,Smc5,Rwdd3,Nsmce2 R-MMU-174417 Telomere C-strand (Lagging Strand) Synthesis 0.9367892820561 -0.0652969077801971 24 3 0.00150905432595573 1988 8688 69263,18972,18974 Rfc3,Pold2,Pole2 R-MMU-390918 Peroxisomal lipid metabolism 0.93680153199118 -0.0652838313549832 30 4 0.00201207243460765 1988 8688 67528,228061,74121,170789 Nudt7,Agps,Acoxl,Acot8 R-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.93680153199118 -0.0652838313549832 30 4 0.00201207243460765 1988 8688 19069,71805,218210,103988 Nup88,Nup93,Nup153,Gck R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.93680153199118 -0.0652838313549832 30 4 0.00201207243460765 1988 8688 66596,20018,78929,67486 Gtf3a,Polr1d,Polr3h,Polr3g R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.93680153199118 -0.0652838313549832 30 4 0.00201207243460765 1988 8688 67486,75627,20018,78929 Polr3g,Snapc1,Polr1d,Polr3h R-MMU-75955 RNA Polymerase II Transcription Elongation 0.938335906244716 -0.0636472850787419 58 9 0.0045271629778672 1988 8688 24116,72949,13716,67655,70122,235497,20924,13871,17420 Nelfa,Ccnt2,Ell,Ctdp1,Mllt3,Leo1,Supt5,Ercc2,Mnat1 R-MMU-112382 Formation of RNA Pol II elongation complex 0.938335906244716 -0.0636472850787419 58 9 0.0045271629778672 1988 8688 24116,72949,13716,70122,67655,235497,20924,13871,17420 Nelfa,Ccnt2,Ell,Mllt3,Ctdp1,Leo1,Supt5,Ercc2,Mnat1 R-MMU-110320 Translesion Synthesis by POLH 0.941170234897346 -0.0606312472599527 18 2 0.00100603621730382 1988 8688 69263,217365 Rfc3,Nploc4 R-MMU-189445 Metabolism of porphyrins 0.941170234897346 -0.0606312472599527 18 2 0.00100603621730382 1988 8688 394433,70383 Ugt1a5,Cox10 R-MMU-163210 Formation of ATP by chemiosmotic coupling 0.941170234897346 -0.0606312472599527 18 2 0.00100603621730382 1988 8688 11957,28080 Atp5j,Atp5o R-MMU-68689 CDC6 association with the ORC:origin complex 0.94273511835731 -0.0589699283224794 11 1 0.000503018108651912 1988 8688 13557 E2f3 R-MMU-174414 Processive synthesis on the C-strand of the telomere 0.94273511835731 -0.0589699283224794 11 1 0.000503018108651912 1988 8688 18972 Pold2 R-MMU-375281 Hormone ligand-binding receptors 0.94273511835731 -0.0589699283224794 11 1 0.000503018108651912 1988 8688 217674 Gphb5 R-MMU-189451 Heme biosynthesis 0.94273511835731 -0.0589699283224794 11 1 0.000503018108651912 1988 8688 70383 Cox10 R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 0.94273511835731 -0.0589699283224794 11 1 0.000503018108651912 1988 8688 170743 Tlr7 R-MMU-199220 Vitamin B5 (pantothenate) metabolism 0.94273511835731 -0.0589699283224794 11 1 0.000503018108651912 1988 8688 66812 Ppcdc R-MMU-189200 Hexose transport 0.945345589679638 -0.056204714976875 48 7 0.00352112676056338 1988 8688 103988,218210,15275,71805,56636,109342,19069 Gck,Nup153,Hk1,Nup93,Fgf21,Slc5a10,Nup88 R-MMU-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.947657889944216 -0.0537617174446493 25 3 0.00150905432595573 1988 8688 66371,116733,330192 Chmp4c,Vps4a,Vps37b R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation 0.948163600321023 -0.0532282174380318 91 15 0.00754527162977867 1988 8688 69263,228980,26416,17248,12144,69181,12021,108099,17246,77976,17535,225182,223970,21975,15258 Rfc3,Taf4,Mapk14,Mdm4,Blm,Dyrk2,Bard1,Prkag2,Mdm2,Nuak1,Mre11a,Rbbp8,Rmi2,Top3a,Hipk2 R-MMU-70153 Glucose transport 0.950023499827459 -0.0512685580330137 43 6 0.00301810865191147 1988 8688 218210,103988,15275,71805,56636,19069 Nup153,Gck,Hk1,Nup93,Fgf21,Nup88 R-MMU-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.952531146669881 -0.0486324726000258 19 2 0.00100603621730382 1988 8688 229776,56317 Cdc14a,Anapc7 R-MMU-5617833 Cilium Assembly 0.954594487859949 -0.0464686487199629 168 30 0.0150905432595573 1988 8688 12589,22628,13191,68642,73738,73916,16570,72938,211446,76260,231214,27078,75465,214444,18005,76707,66482,217935,238799,319845,27373,19088,99100,213081,13196,333329,53869,18763,382090,264134 Ift81,Ywhag,Dctn1,Tmem216,Haus7,Ift57,Kif3c,Hspb11,Exoc3,Ttc8,Cc2d2a,B9d1,Dynlrb2,Cdk5rap2,Nek2,Clasp1,Exoc2,Wdr60,Tnpo1,Bbs9,Csnk1e,Prkar2b,Cep152,Wdr19,Asap1,Cngb1,Rab11a,Pkd1,Cep162,Ttc26 R-MMU-1170546 Prolactin receptor signaling 0.955287685976602 -0.0457427420053093 32 4 0.00201207243460765 1988 8688 16452,19116,14600,19109 Jak2,Prlr,Ghr,Prl R-MMU-73933 Resolution of Abasic Sites (AP sites) 0.955287685976602 -0.0457427420053093 32 4 0.00201207243460765 1988 8688 69263,18972,18970,11545 Rfc3,Pold2,Polb,Parp1 R-MMU-76046 RNA Polymerase III Transcription Initiation 0.955690732434758 -0.0453209199059612 38 5 0.00251509054325956 1988 8688 66596,20018,78929,75627,67486 Gtf3a,Polr1d,Polr3h,Snapc1,Polr3g R-MMU-74158 RNA Polymerase III Transcription 0.955690732434758 -0.0453209199059612 38 5 0.00251509054325956 1988 8688 78929,20018,75627,67486,66596 Polr3h,Polr1d,Snapc1,Polr3g,Gtf3a R-MMU-622323 Presynaptic nicotinic acetylcholine receptors 0.95585515811008 -0.0451488856623244 12 1 0.000503018108651912 1988 8688 108043 Chrnb3 R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.95585515811008 -0.0451488856623244 12 1 0.000503018108651912 1988 8688 11820 App R-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex 0.956764656288752 -0.0441978359655915 26 3 0.00150905432595573 1988 8688 18972,69263,76843 Pold2,Rfc3,Dtl R-MMU-157579 Telomere Maintenance 0.956764656288752 -0.0441978359655915 26 3 0.00150905432595573 1988 8688 18974,18972,69263 Pole2,Pold2,Rfc3 R-MMU-180786 Extension of Telomeres 0.956764656288752 -0.0441978359655915 26 3 0.00150905432595573 1988 8688 18974,18972,69263 Pole2,Pold2,Rfc3 R-MMU-4615885 SUMOylation of DNA replication proteins 0.957115160898601 -0.0438315594516535 44 6 0.00301810865191147 1988 8688 21969,20610,218210,16319,19069,71805 Top1,Sumo3,Nup153,Incenp,Nup88,Nup93 R-MMU-73893 DNA Damage Bypass 0.957115160898601 -0.0438315594516535 44 6 0.00301810865191147 1988 8688 217365,76843,216835,27015,69263,18972 Nploc4,Dtl,Usp43,Polk,Rfc3,Pold2 R-MMU-2142753 Arachidonic acid metabolism 0.959208602441126 -0.04164670695925 72 11 0.00553319919517103 1988 8688 21391,13109,11690,19223,11689,11684,17164,19224,18783,12408,18979 Tbxas1,Cyp2j5,Alox5ap,Ptgis,Alox5,Alox12,Mapkapk2,Ptgs1,Pla2g4a,Cbr1,Pon1 R-MMU-6807878 COPI-mediated anterograde transport 0.959208602441126 -0.04164670695925 72 11 0.00553319919517103 1988 8688 13191,67542,56395,56358,56494,22428,109676,20742,77038,11735,16333 Dctn1,Cog6,Tmem115,Copz2,Gosr2,Dctn6,Ank2,Sptbn1,Arfgap2,Ank3,Ins1 R-MMU-5334727 Mus musculus biological processes 0.959436677011567 -0.0414089615313092 238 44 0.0221327967806841 1988 8688 264064,79362,59027,327987,20787,76199,18143,64009,27373,11865,77053,16600,69790,319177,12606,20181,13654,223697,12144,67381,20602,230753,26914,12952,16905,14815,94112,19357,20018,12953,19883,16452,12702,26972,17979,16367,51788,14068,21975,15078,13433,28077,68975,16906 Cdk8,Bhlhe41,Nampt,Med13,Srebf1,Med13l,Npas2,Syne1,Csnk1e,Arntl,Sun1,Klf4,Med30,Hist1h2ba,Cebpa,Rxra,Egr2,Sun2,Blm,Med4,Ncor2,Thrap3,H2afy,Cry1,Lmna,Nr3c1,Med15,Rad21,Polr1d,Cry2,Rora,Jak2,Socs3,Spo11,Ncoa3,Irs1,H2afz,F7,Top3a,H3f3a,Dnmt1,Med10,Med27,Lmnb1 R-MMU-69186 Lagging Strand Synthesis 0.961775930084244 -0.0389737763570678 20 2 0.00100603621730382 1988 8688 18972,69263 Pold2,Rfc3 R-MMU-2559580 Oxidative Stress Induced Senescence 0.962299267550209 -0.0384297877650276 78 12 0.00603621730382294 1988 8688 17246,26419,17164,26399,12571,15078,22166,17248,26416,54383,16476,216850 Mdm2,Mapk8,Mapkapk2,Map2k6,Cdk6,H3f3a,Txn1,Mdm4,Mapk14,Phc2,Jun,Kdm6b R-MMU-3301854 Nuclear Pore Complex (NPC) Disassembly 0.962527432659567 -0.0381927117618721 33 4 0.00201207243460765 1988 8688 19069,71805,59126,218210 Nup88,Nup93,Nek6,Nup153 R-MMU-73884 Base Excision Repair 0.962527432659567 -0.0381927117618721 33 4 0.00201207243460765 1988 8688 69263,18972,11545,18970 Rfc3,Pold2,Parp1,Polb R-MMU-983169 Class I MHC mediated antigen processing & presentation 0.963459231152287 -0.0372251053054728 215 39 0.0196177062374245 1988 8688 12491,387524,27401,75234,20334,50760,16410,74165,74646,24105,231670,17969,74244,30945,240028,103583,66998,269514,224826,26443,50754,66313,17970,69754,67845,17463,101358,19820,26440,380928,22019,207215,67731,320118,19155,226098,16419,69608,50764 Cd36,Znrf2,Skp2,Rnf19b,Sec23a,Fbxo17,Itgav,Fbxl22,Spsb1,Rbck1,Fbxo21,Ncf1,Atg7,Rnf19a,Lnpep,Fbxw11,Psmd5,Fbxl4,Ubr2,Psma6,Fbxw7,Smurf2,Ncf2,Fbxo7,Rnf115,Psmd7,Fbxl14,Rlim,Psma1,Lmo7,Tpp2,Fbxo40,Fbxo32,Fbxl13,Npepps,Hectd2,Itgb5,Sec24d,Fbxo15 R-MMU-5693607 Processing of DNA double-strand break ends 0.964040917369357 -0.0366215398684748 73 11 0.00553319919517103 1988 8688 225182,17535,70620,223970,21975,27223,12144,69263,232314,107976,12021 Rbbp8,Mre11a,Ube2v2,Rmi2,Top3a,Trp53bp1,Blm,Rfc3,Ppp4r2,Babam2,Bard1 R-MMU-3108214 SUMOylation of DNA damage response and repair proteins 0.964040917369357 -0.0366215398684748 73 11 0.00553319919517103 1988 8688 54383,11545,218210,12144,66341,68501,20610,19069,226026,71805,19357 Phc2,Parp1,Nup153,Blm,Eid3,Nsmce2,Sumo3,Nup88,Smc5,Nup93,Rad21 R-MMU-3214842 HDMs demethylate histones 0.964712975755151 -0.035924656336171 51 7 0.00352112676056338 1988 8688 338523,193796,99982,216850,67014,104263,320595 Kdm7a,Kdm4b,Kdm1a,Kdm6b,Riox2,Kdm3a,Phf8 R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.965970412328502 -0.0346220742982204 13 1 0.000503018108651912 1988 8688 11826 Aqp1 R-MMU-3371453 Regulation of HSF1-mediated heat shock response 0.96645023344648 -0.0341254731789062 57 8 0.00402414486921529 1988 8688 19069,17164,71805,15511,70369,29810,15481,218210 Nup88,Mapkapk2,Nup93,Hspa1b,Bag5,Bag3,Hspa8,Nup153 R-MMU-165159 mTOR signalling 0.96818228471752 -0.0323348987751912 40 5 0.00251509054325956 1988 8688 19744,74370,68576,22084,108099 Rheb,Rptor,Lamtor5,Tsc2,Prkag2 R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.970700329019312 -0.02973747931345 28 3 0.00150905432595573 1988 8688 20924,13871,17420 Supt5,Ercc2,Mnat1 R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes 0.972198908610187 -0.0281948569694506 75 11 0.00553319919517103 1988 8688 19088,27373,99100,51885,214444,101706,18005,76707,22628,73738,13191 Prkar2b,Csnk1e,Cep152,Tubgcp4,Cdk5rap2,Numa1,Nek2,Clasp1,Ywhag,Haus7,Dctn1 R-MMU-380287 Centrosome maturation 0.972198908610187 -0.0281948569694506 75 11 0.00553319919517103 1988 8688 19088,27373,51885,99100,214444,18005,101706,76707,22628,73738,13191 Prkar2b,Csnk1e,Tubgcp4,Cep152,Cdk5rap2,Nek2,Numa1,Clasp1,Ywhag,Haus7,Dctn1 R-MMU-109703 PKB-mediated events 0.973124479574855 -0.027243271191854 41 5 0.00251509054325956 1988 8688 74370,68576,19744,22084,108099 Rptor,Lamtor5,Rheb,Tsc2,Prkag2 R-MMU-418594 G alpha (i) signalling events 0.973191476392425 -0.0271744264419655 209 37 0.0186116700201207 1988 8688 12801,13610,20297,11542,80901,56066,17329,15557,11551,19065,84112,12767,12062,18166,13609,109648,57254,20315,239283,18619,12778,216749,20608,242425,11820,225192,12374,74191,65086,30878,56183,14767,12775,14745,70839,140795,11606 Cnr1,S1pr3,Ccl20,Adora3,Cxcr6,Cxcl11,Cxcl9,Htr1f,Adra2a,Npy4r,Sucnr1,Cxcr4,Bdkrb2,Npy1r,S1pr1,Npy,Tas2r119,Cxcl12,Oxgr1,Penk,Ackr3,Nmur2,Sstr4,Gabbr2,App,Hrh4,Casr,P2ry13,Lpar3,Apln,Nmu,Nmur1,Ccr7,Lpar1,P2ry12,P2ry14,Agt R-MMU-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.97376877777616 -0.02658139800246 14 1 0.000503018108651912 1988 8688 18972 Pold2 R-MMU-69298 Association of licensing factors with the pre-replicative complex 0.97376877777616 -0.02658139800246 14 1 0.000503018108651912 1988 8688 13557 E2f3 R-MMU-391903 Eicosanoid ligand-binding receptors 0.97376877777616 -0.02658139800246 14 1 0.000503018108651912 1988 8688 19220 Ptgfr R-MMU-69166 Removal of the Flap Intermediate 0.97376877777616 -0.02658139800246 14 1 0.000503018108651912 1988 8688 18972 Pold2 R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.973908202942394 -0.0264382272735845 53 7 0.00352112676056338 1988 8688 56358,26951,668303,77038,16570,16563,16593 Copz2,Zw10,Kif26a,Arfgap2,Kif3c,Kif2a,Klc1 R-MMU-1592230 Mitochondrial biogenesis 0.975349520567652 -0.0249593895903477 22 2 0.00100603621730382 1988 8688 26416,108099 Mapk14,Prkag2 R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.975955412309512 -0.0243383777217021 29 3 0.00150905432595573 1988 8688 67486,20018,78929 Polr3g,Polr1d,Polr3h R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.977236789531261 -0.0230262924037566 48 6 0.00301810865191147 1988 8688 267019,14109,67204,68135,20090,66475 Rps15a,Fau,Eif2s2,Eif3h,Rps29,Rps23 R-MMU-5693538 Homology Directed Repair 0.97755871136184 -0.0226969261520518 109 17 0.0085513078470825 1988 8688 12144,69263,107976,232314,27223,12021,11545,18972,17535,19363,57434,27015,225182,70620,21975,223970,13870 Blm,Rfc3,Babam2,Ppp4r2,Trp53bp1,Bard1,Parp1,Pold2,Mre11a,Rad51b,Xrcc2,Polk,Rbbp8,Ube2v2,Top3a,Rmi2,Ercc1 R-MMU-5620912 Anchoring of the basal body to the plasma membrane 0.977594945908263 -0.0226598604756097 93 14 0.00704225352112676 1988 8688 22628,76707,13191,68642,73738,27373,19088,231214,99100,27078,53869,214444,18005,382090 Ywhag,Clasp1,Dctn1,Tmem216,Haus7,Csnk1e,Prkar2b,Cc2d2a,Cep152,B9d1,Rab11a,Cdk5rap2,Nek2,Cep162 R-MMU-4641257 Degradation of AXIN 0.977628167938915 -0.0226258776217661 54 7 0.00352112676056338 1988 8688 66313,21951,26443,26440,17463,66998,12006 Smurf2,Tnks,Psma6,Psma1,Psmd7,Psmd5,Axin2 R-MMU-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.978344125990505 -0.0218938037720615 104 16 0.00804828973843058 1988 8688 17535,18972,12144,232314,107976,69263,27223,12021,27015,225182,70620,21975,223970,13870,19363,57434 Mre11a,Pold2,Blm,Ppp4r2,Babam2,Rfc3,Trp53bp1,Bard1,Polk,Rbbp8,Ube2v2,Top3a,Rmi2,Ercc1,Rad51b,Xrcc2 R-MMU-211897 Cytochrome P450 - arranged by substrate type 0.979217614144611 -0.0210013790845856 99 15 0.00754527162977867 1988 8688 13123,21391,13070,56050,11864,13109,20181,19223,13074,14148,13075,13082,56448,11622,232174 Cyp7b1,Tbxas1,Cyp11a1,Cyp39a1,Arnt2,Cyp2j5,Rxra,Ptgis,Cyp17a1,Fdx1,Cyp19a1,Cyp26a1,Cyp2d22,Ahr,Cyp26b1 R-MMU-69202 Cyclin E associated events during G1/S transition 0.979240914419835 -0.0209775845799938 66 9 0.0045271629778672 1988 8688 66998,22390,17463,26440,17420,12443,12447,27401,26443 Psmd5,Wee1,Psmd7,Psma1,Mnat1,Ccnd1,Ccne1,Skp2,Psma6 R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry 0.979240914419835 -0.0209775845799938 66 9 0.0045271629778672 1988 8688 12447,27401,26443,22390,66998,26440,17463,17420,12443 Ccne1,Skp2,Psma6,Wee1,Psmd5,Psma1,Psmd7,Mnat1,Ccnd1 R-MMU-1295596 Spry regulation of FGF signaling 0.97978072956643 -0.0204264776926198 15 1 0.000503018108651912 1988 8688 20779 Src R-MMU-194002 Glucocorticoid biosynthesis 0.97978072956643 -0.0204264776926198 15 1 0.000503018108651912 1988 8688 13074 Cyp17a1 R-MMU-5358508 Mismatch Repair 0.97978072956643 -0.0204264776926198 15 1 0.000503018108651912 1988 8688 18972 Pold2 R-MMU-69183 Processive synthesis on the lagging strand 0.97978072956643 -0.0204264776926198 15 1 0.000503018108651912 1988 8688 18972 Pold2 R-MMU-110312 Translesion synthesis by REV1 0.97978072956643 -0.0204264776926198 15 1 0.000503018108651912 1988 8688 69263 Rfc3 R-MMU-933541 TRAF6 mediated IRF7 activation 0.980252768385247 -0.0199448136512284 23 2 0.00100603621730382 1988 8688 16363,15977 Irf2,Ifnb1 R-MMU-72086 mRNA Capping 0.980305843458984 -0.0198906708437351 30 3 0.00150905432595573 1988 8688 13871,20924,17420 Ercc2,Supt5,Mnat1 R-MMU-1799339 SRP-dependent cotranslational protein targeting to membrane 0.981251800523432 -0.018926174958864 89 13 0.00653923541247485 1988 8688 56040,19946,19944,14109,19981,20090,217337,20813,66475,68436,267019,19921,100502825 Rplp1,Rpl30,Rpl29,Fau,Rpl37a,Rps29,Srp68,Srp14,Rps23,Rpl34,Rps15a,Rpl19,Rpl37rt R-MMU-380259 Loss of Nlp from mitotic centrosomes 0.982027778043294 -0.0181356838146169 67 9 0.0045271629778672 1988 8688 76707,22628,73738,13191,214444,18005,19088,27373,99100 Clasp1,Ywhag,Haus7,Dctn1,Cdk5rap2,Nek2,Prkar2b,Csnk1e,Cep152 R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.982027778043294 -0.0181356838146169 67 9 0.0045271629778672 1988 8688 18005,214444,99100,19088,27373,73738,13191,76707,22628 Nek2,Cdk5rap2,Cep152,Prkar2b,Csnk1e,Haus7,Dctn1,Clasp1,Ywhag R-MMU-5658442 Regulation of RAS by GAPs 0.982027778043294 -0.0181356838146169 67 9 0.0045271629778672 1988 8688 26443,54153,69601,218397,19414,66998,114715,17463,26440 Psma6,Rasa4,Dab2ip,Rasa1,Rasa3,Psmd5,Spred1,Psmd7,Psma1 R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition 0.982423143261634 -0.0177331639864134 84 12 0.00603621730382294 1988 8688 214444,18005,77744,27373,19088,99100,71648,103583,22628,76707,13191,73738 Cdk5rap2,Nek2,Bora,Csnk1e,Prkar2b,Cep152,Optn,Fbxw11,Ywhag,Clasp1,Dctn1,Haus7 R-MMU-390522 Striated Muscle Contraction 0.983898362388843 -0.0162326775199307 31 3 0.00150905432595573 1988 8688 59069,22003,21956 Tpm3,Tpm1,Tnnt2 R-MMU-68962 Activation of the pre-replicative complex 0.983898362388843 -0.0162326775199307 31 3 0.00150905432595573 1988 8688 17219,18974,12545 Mcm6,Pole2,Cdc7 R-MMU-73777 RNA Polymerase I Chain Elongation 0.983898362388843 -0.0162326775199307 31 3 0.00150905432595573 1988 8688 20018,17420,13871 Polr1d,Mnat1,Ercc2 R-MMU-6782135 Dual incision in TC-NER 0.983959570105227 -0.0161704700654259 62 8 0.00402414486921529 1988 8688 18972,71101,17420,27015,13870,13871,69263,319955 Pold2,Uvssa,Mnat1,Polk,Ercc1,Ercc2,Rfc3,Ercc6 R-MMU-69190 DNA strand elongation 0.984203994414611 -0.0159220920189594 24 2 0.00100603621730382 1988 8688 69263,18972 Rfc3,Pold2 R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle 0.984415332327752 -0.0157073852840592 16 1 0.000503018108651912 1988 8688 207777 Tspoap1 R-MMU-5656121 Translesion synthesis by POLI 0.984415332327752 -0.0157073852840592 16 1 0.000503018108651912 1988 8688 69263 Rfc3 R-MMU-69205 G1/S-Specific Transcription 0.984415332327752 -0.0157073852840592 16 1 0.000503018108651912 1988 8688 12447 Ccne1 R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle 0.984415332327752 -0.0157073852840592 16 1 0.000503018108651912 1988 8688 207777 Tspoap1 R-MMU-2559583 Cellular Senescence 0.985060080678014 -0.0150526440580079 139 22 0.0110663983903421 1988 8688 22166,20111,12447,54383,18033,56317,17164,26399,12571,16906,13875,15078,26416,17248,23871,216850,16476,23872,17535,15364,26419,17246 Txn1,Rps6ka1,Ccne1,Phc2,Nfkb1,Anapc7,Mapkapk2,Map2k6,Cdk6,Lmnb1,Erf,H3f3a,Mapk14,Mdm4,Ets1,Kdm6b,Jun,Ets2,Mre11a,Hmga2,Mapk8,Mdm2 R-MMU-194441 Metabolism of non-coding RNA 0.986128007307958 -0.0139691079500776 51 6 0.00301810865191147 1988 8688 107686,71805,53975,237221,19069,218210 Snrpd2,Nup93,Ddx20,Gemin8,Nup88,Nup153 R-MMU-191859 snRNP Assembly 0.986128007307958 -0.0139691079500776 51 6 0.00301810865191147 1988 8688 237221,19069,71805,107686,53975,218210 Gemin8,Nup88,Nup93,Snrpd2,Ddx20,Nup153 R-MMU-5689880 Ub-specific processing proteases 0.986317721975437 -0.0137767430446734 171 28 0.0140845070422535 1988 8688 17463,327799,18970,17127,26440,67952,21812,15251,329908,77125,27401,26443,66313,26409,12006,66998,19211,14462,74996,17246,18035,235441,22030,22217,22258,74256,21951,17248 Psmd7,Usp44,Polb,Smad3,Psma1,Tomm20,Tgfbr1,Hif1a,Usp24,Il33,Skp2,Psma6,Smurf2,Map3k7,Axin2,Psmd5,Pten,Gata3,Usp47,Mdm2,Nfkbia,Usp3,Traf2,Usp12,Usp4,Cyld,Tnks,Mdm4 R-MMU-2262752 Cellular responses to stress 0.986330363783952 -0.0137639259501233 360 66 0.0331991951710262 1988 8688 23871,17248,108058,11927,17969,26419,15364,17535,66998,14778,15511,66795,54383,20111,12323,56317,14782,29810,74370,15516,216850,68196,20657,22084,112407,19744,19069,26399,12571,112405,15251,225326,15078,16906,52639,74244,29806,218210,67443,12359,68576,70369,20655,12447,66734,108099,50490,11758,26416,16476,15481,17246,23872,57436,17684,26443,22166,18033,66371,17164,71805,78610,17970,17463,13875,26440 Ets1,Mdm4,Camk2d,Atox1,Ncf1,Mapk8,Hmga2,Mre11a,Psmd5,Gpx3,Hspa1b,Atg10,Phc2,Rps6ka1,Camk2b,Anapc7,Gsr,Bag3,Rptor,Hsp90ab1,Kdm6b,Hsbp1,Sod3,Tsc2,Egln3,Rheb,Nup88,Map2k6,Cdk6,Egln1,Hif1a,Pik3c3,H3f3a,Lmnb1,Wipi1,Atg7,Limd1,Nup153,Map1lc3b,Cat,Lamtor5,Bag5,Sod1,Ccne1,Map1lc3a,Prkag2,Nox4,Prdx6,Mapk14,Jun,Hspa8,Mdm2,Ets2,Gabarapl1,Cited2,Psma6,Txn1,Nfkb1,Chmp4c,Mapkapk2,Nup93,Uvrag,Ncf2,Psmd7,Erf,Psma1 R-MMU-4570464 SUMOylation of RNA binding proteins 0.986583583585752 -0.0135072297029014 45 5 0.00251509054325956 1988 8688 15387,54383,218210,19069,71805 Hnrnpk,Phc2,Nup153,Nup88,Nup93 R-MMU-2262749 Cellular response to hypoxia 0.986594977422661 -0.0134956809894355 69 9 0.0045271629778672 1988 8688 26443,29806,15251,112405,26440,112407,17463,17684,66998 Psma6,Limd1,Hif1a,Egln1,Psma1,Egln3,Psmd7,Cited2,Psmd5 R-MMU-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 0.986594977422661 -0.0134956809894355 69 9 0.0045271629778672 1988 8688 15251,112405,17463,17684,112407,26440,66998,26443,29806 Hif1a,Egln1,Psmd7,Cited2,Egln3,Psma1,Psmd5,Psma6,Limd1 R-MMU-73772 RNA Polymerase I Promoter Escape 0.986858087538966 -0.0132290315083452 32 3 0.00150905432595573 1988 8688 13871,17420,20018 Ercc2,Mnat1,Polr1d R-MMU-5696398 Nucleotide Excision Repair 0.987278254069649 -0.0128033602634859 103 15 0.00754527162977867 1988 8688 69263,319955,19359,11545,27015,108679,17420,71101,225280,18972,70620,20610,13871,227195,13870 Rfc3,Ercc6,Rad23b,Parp1,Polk,Cops8,Mnat1,Uvssa,Ino80c,Pold2,Ube2v2,Sumo3,Ercc2,Ino80d,Ercc1 R-MMU-72312 rRNA processing 0.987875683569596 -0.0121984154976304 125 19 0.00955734406438632 1988 8688 19944,19981,213895,66446,68436,100502825,57316,67276,215193,19946,50911,76130,56040,216987,50912,14791,67755,19921,73674 Rpl29,Rpl37a,Bms1,Exosc7,Rpl34,Rpl37rt,C1d,Eri1,Utp25,Rpl30,Exosc9,Las1l,Rplp1,Utp6,Exosc10,Emg1,Ddx47,Rpl19,Wdr75 R-MMU-8868773 rRNA processing in the nucleus and cytosol 0.987875683569596 -0.0121984154976304 125 19 0.00955734406438632 1988 8688 57316,68436,100502825,66446,213895,19944,19981,73674,50912,14791,67755,19921,56040,216987,19946,215193,67276,76130,50911 C1d,Rpl34,Rpl37rt,Exosc7,Bms1,Rpl29,Rpl37a,Wdr75,Exosc10,Emg1,Ddx47,Rpl19,Rplp1,Utp6,Rpl30,Utp25,Eri1,Las1l,Exosc9 R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.987875683569596 -0.0121984154976304 125 19 0.00955734406438632 1988 8688 19944,19981,66446,213895,100502825,68436,57316,50911,76130,67276,215193,19946,216987,56040,19921,67755,14791,50912,73674 Rpl29,Rpl37a,Exosc7,Bms1,Rpl37rt,Rpl34,C1d,Exosc9,Las1l,Eri1,Utp25,Rpl30,Utp6,Rplp1,Rpl19,Ddx47,Emg1,Exosc10,Wdr75 R-MMU-5423646 Aflatoxin activation and detoxification 0.987988016761235 -0.0120847100919987 17 1 0.000503018108651912 1988 8688 211666 Mgst2 R-MMU-4608870 Asymmetric localization of PCP proteins 0.988121387205517 -0.0119497272370847 58 7 0.00352112676056338 1988 8688 17463,106042,26440,66998,66313,26443,93840 Psmd7,Prickle1,Psma1,Psmd5,Smurf2,Psma6,Vangl2 R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.988201686733688 -0.0118684656971329 64 8 0.00402414486921529 1988 8688 112405,15251,66998,112407,17463,26440,26443,29806 Egln1,Hif1a,Psmd5,Egln3,Psmd7,Psma1,Psma6,Limd1 R-MMU-8854518 AURKA Activation by TPX2 0.988450191641226 -0.0116170254596634 70 9 0.0045271629778672 1988 8688 18005,214444,99100,27373,19088,13191,73738,22628,76707 Nek2,Cdk5rap2,Cep152,Csnk1e,Prkar2b,Dctn1,Haus7,Ywhag,Clasp1 R-MMU-392499 Metabolism of proteins 0.988861016554465 -0.0112014865020648 1115 226 0.113682092555332 1988 8688 12021,218210,12042,244682,66475,14799,192193,20442,74996,19944,23802,54342,30937,13032,12876,67204,235441,19921,30060,15387,21787,329777,14607,16795,18548,27401,66789,18793,230801,230815,229603,18970,19946,17127,77038,16008,11606,12182,15481,100502825,20447,21951,241230,20338,50798,21838,17246,69608,225280,20698,98388,80294,11890,66286,66212,17463,17342,26440,20444,71805,26938,50935,12313,19244,242362,19128,320840,17380,19981,109359,13666,22030,218476,545260,67542,16009,16319,271970,53625,74091,20334,14465,11650,20610,69048,330817,78754,22217,22258,13036,11889,12144,67196,269181,19326,11551,18550,56336,16333,53869,18035,20440,14584,77125,71974,66967,70495,231605,64138,94192,229595,211446,17829,67099,14068,76509,17425,12006,17156,20449,22193,66568,20441,13191,67768,20813,56494,381694,235106,21812,20454,21969,233744,107895,53618,22213,225131,107976,227327,27223,14526,14462,271786,108148,72433,19359,218138,107607,22166,26443,226641,16324,320311,66341,72978,67952,11735,56040,267019,17918,66482,17248,66998,71897,68501,66510,72061,23956,226026,13982,54383,93841,77739,78928,235497,109978,16323,23794,20742,227195,22428,67128,232984,89867,74256,11545,171212,78943,68436,16006,18491,20090,67819,12314,23850,19211,109676,105522,14109,13809,19357,16000,241062,56395,50873,329908,235505,110265,27392,109161,59021,217337,56358,29858,26409,66313,231050,76687,74008,327799,14537,19069,68135,12984,15251,67857 Bard1,Nup153,Bcl10,Cntn5,Rps23,Gria1,Edem1,St3gal1,Usp47,Rpl29,Amfr,Gnpnat1,Lmcd1,Ctsc,Cpe,Eif2s2,Usp3,Rpl19,Meltf,Hnrnpk,Tfg,Pigk,Gip,Large1,Pcsk1,Skp2,Alg14,Plaur,Pigv,Man1c1,Otud7b,Polb,Rpl30,Smad3,Arfgap2,Igfbp2,Agt,Bst1,Hspa8,Rpl37rt,St6galnac3,Tnks,St8sia6,Sel1l,Gne,Thy1,Mdm2,Sec24d,Ino80c,Sphk1,Chst10,Pofut2,Asgr2,Sec11c,Sec61b,Psmd7,Mitf,Psma1,St3gal2,Nup93,St6galnac5,St6galnac6,Calm1,Ptp4a2,Manea,Pros1,Negr1,Mme,Rpl37a,Abraxas2,Eif2ak3,Traf2,Gcnt4,Arsi,Cog6,Igfbp3,Incenp,Arsj,B3gnt2,Npl,Sec23a,Gata6,Alppl2,Sumo3,Slc30a5,Dhps,Galnt15,Usp12,Usp4,Ctsh,Asgr1,Blm,Ube2t,Mgat4a,Rab11b,Adra2a,Furin,B4galt5,Ins1,Rab11a,Nfkbia,St6gal1,Gfpt2,Il33,Prmt3,Edem3,Atp6ap2,Galnt9,Ctsz,C1galt1,Adamtsl4,Exoc3,Muc1,Mettl21a,F7,Plet1,Foxk1,Axin2,Man1a2,St8sia1,Ube2e3,Rwdd3,St3gal3,Dctn1,N6amt1,Srp14,Gosr2,B3glct,Ntm,Tgfbr1,St3gal5,Top1,Spon1,Mgat5,Fut8,Ube2g2,Wac,Babam2,B3gnt7,Trp53bp1,Gcg,Gata3,Galnt13,Galnt2,Rab38,Rad23b,Gmds,Nod1,Txn1,Psma6,Atf6,Inhbb,Rnf152,Eid3,Cnih3,Tomm20,Ank3,Rplp1,Rps15a,Myo5a,Exoc2,Mdm4,Psmd5,Lypd6b,Nsmce2,Rnf181,Aopep,Neu2,Smc5,Esr1,Phc2,Uchl4,Adamtsl1,Pigt,Leo1,Art4,Inhba,Adamts5,Sptbn1,Ino80d,Dctn6,Ube2g1,B3gnt8,Sec16b,Cyld,Parp1,Galnt10,Ern1,Rpl34,Igfbp1,Pappa,Rps29,Derl1,Calm2,Pappa2,Pten,Ank2,Ankrd28,Fau,Enpep,Rad21,Igf1,Pgap1,Tmem115,Prkn,Usp24,Cd109,Msra,Pign,Ube2q2,Rab2a,Srp68,Copz2,Pmm1,Map3k7,Smurf2,Galnt11,Spcs3,Arsg,Usp44,Gcnt1,Nup88,Eif3h,Csf2rb2,Hif1a,Ppp6c R-MMU-73863 RNA Polymerase I Transcription Termination 0.98929115305073 -0.0107665993284156 33 3 0.00150905432595573 1988 8688 13871,20018,17420 Ercc2,Polr1d,Mnat1 R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.989743975805725 -0.0103089795961582 88 12 0.00603621730382294 1988 8688 19946,14109,19981,19944,56040,68436,267019,100502825,19921,20090,19704,66475 Rpl30,Fau,Rpl37a,Rpl29,Rplp1,Rpl34,Rps15a,Rpl37rt,Rpl19,Rps29,Upf1,Rps23 R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 0.989902465031849 -0.0101488608767813 59 7 0.00352112676056338 1988 8688 26443,12443,66998,26440,12447,27401,17463 Psma6,Ccnd1,Psmd5,Psma1,Ccne1,Skp2,Psmd7 R-MMU-113510 E2F mediated regulation of DNA replication 0.989933354899125 -0.0101176564031904 26 2 0.00100603621730382 1988 8688 12447,73699 Ccne1,Ppp2r1b R-MMU-1538133 G0 and Early G1 0.989933354899125 -0.0101176564031904 26 2 0.00100603621730382 1988 8688 12447,13548 Ccne1,Dyrk1a R-MMU-72202 Transport of Mature Transcript to Cytoplasm 0.990063794301481 -0.00998589924121987 71 9 0.0045271629778672 1988 8688 71713,20383,218210,73666,56488,66441,19069,64340,71805 Cdc40,Srsf3,Nup153,Thoc3,Nxt1,Magohb,Nup88,Dhx38,Nup93 R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.990063794301481 -0.00998589924121987 71 9 0.0045271629778672 1988 8688 71713,218210,20383,73666,66441,56488,19069,71805,64340 Cdc40,Nup153,Srsf3,Thoc3,Magohb,Nxt1,Nup88,Nup93,Dhx38 R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.990115013114065 -0.00993416773858643 53 6 0.00301810865191147 1988 8688 26443,15481,66998,15511,26440,17463 Psma6,Hspa8,Psmd5,Hspa1b,Psma1,Psmd7 R-MMU-211859 Biological oxidations 0.990519356055682 -0.00952587133261882 231 39 0.0196177062374245 1988 8688 13082,216558,20887,15516,13885,394433,66427,68214,13075,19224,14148,13074,19223,22235,12846,66112,23972,18105,68044,228608,13070,232174,242585,108652,56050,213012,211666,21391,11622,56448,231583,67768,23971,107146,20181,13109,11864,13123,58810 Cyp26a1,Ugp2,Sult1a1,Hsp90ab1,Esd,Ugt1a5,Cyb5b,Gsto2,Cyp19a1,Ptgs1,Fdx1,Cyp17a1,Ptgis,Ugdh,Comt,Marc1,Papss2,Nqo2,Chac2,Smox,Cyp11a1,Cyp26b1,Slc35d1,Slc35b3,Cyp39a1,Abhd10,Mgst2,Tbxas1,Ahr,Cyp2d22,Slc26a1,N6amt1,Papss1,Glyat,Rxra,Cyp2j5,Arnt2,Cyp7b1,Akr1a1 R-MMU-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.990621283258187 -0.00942297383955578 47 5 0.00251509054325956 1988 8688 57254,12374,14816,83770,242425 Tas2r119,Casr,Grm1,Tas1r2,Gabbr2 R-MMU-5674135 MAP2K and MAPK activation 0.990742003918302 -0.00930111768016681 18 1 0.000503018108651912 1988 8688 110157 Raf1 R-MMU-5689901 Metalloprotease DUBs 0.991287172656926 -0.00875100594738822 34 3 0.00150905432595573 1988 8688 12021,109359,107976 Bard1,Abraxas2,Babam2 R-MMU-68875 Mitotic Prophase 0.991655353334486 -0.00837965813779206 78 10 0.00503018108651911 1988 8688 18750,59021,218210,16905,19069,320595,244329,71805,59126,14245 Prkca,Rab2a,Nup153,Lmna,Nup88,Phf8,Mcph1,Nup93,Nek6,Lpin1 R-MMU-69541 Stabilization of p53 0.991675868758952 -0.00835897029277859 54 6 0.00301810865191147 1988 8688 17248,17246,26443,26440,17463,66998 Mdm4,Mdm2,Psma6,Psma1,Psmd7,Psmd5 R-MMU-72649 Translation initiation complex formation 0.991675868758952 -0.00835897029277859 54 6 0.00301810865191147 1988 8688 14109,267019,68135,67204,20090,66475 Fau,Rps15a,Eif3h,Eif2s2,Rps29,Rps23 R-MMU-2299718 Condensation of Prophase Chromosomes 0.991978464392106 -0.00805388121506532 27 2 0.00100603621730382 1988 8688 244329,320595 Mcph1,Phf8 R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.992737557418918 -0.0072889424979044 61 7 0.00352112676056338 1988 8688 27015,69263,17420,18972,71101,13871,319955 Polk,Rfc3,Mnat1,Pold2,Uvssa,Ercc2,Ercc6 R-MMU-674695 RNA Polymerase II Pre-transcription Events 0.992807861687312 -0.00721812642112568 79 10 0.00503018108651911 1988 8688 20924,13871,17420,72949,24116,235497,228980,13716,70122,67655 Supt5,Ercc2,Mnat1,Ccnt2,Nelfa,Leo1,Taf4,Ell,Mllt3,Ctdp1 R-MMU-176412 Phosphorylation of the APC/C 0.992864829324246 -0.00716074774315224 19 1 0.000503018108651912 1988 8688 56317 Anapc7 R-MMU-211935 Fatty acids 0.992864829324246 -0.00716074774315224 19 1 0.000503018108651912 1988 8688 13109 Cyp2j5 R-MMU-72702 Ribosomal scanning and start codon recognition 0.993001127320706 -0.0070234796700295 55 6 0.00301810865191147 1988 8688 68135,67204,20090,66475,267019,14109 Eif3h,Eif2s2,Rps29,Rps23,Rps15a,Fau R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.993001127320706 -0.0070234796700295 55 6 0.00301810865191147 1988 8688 68135,67204,20090,66475,267019,14109 Eif3h,Eif2s2,Rps29,Rps23,Rps15a,Fau R-MMU-6803529 FGFR2 alternative splicing 0.993615244039692 -0.0064052256906499 28 2 0.00100603621730382 1988 8688 207920,93686 Esrp1,Rbfox2 R-MMU-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.993728851141185 -0.00629089511056299 74 9 0.0045271629778672 1988 8688 69263,319955,18972,71101,27015,17420,108679,13870,13871 Rfc3,Ercc6,Pold2,Uvssa,Polk,Mnat1,Cops8,Ercc1,Ercc2 R-MMU-69580 p53-Dependent G1/S DNA damage checkpoint 0.993854755810702 -0.00616420391705057 62 7 0.00352112676056338 1988 8688 12447,26440,17463,66998,17248,17246,26443 Ccne1,Psma1,Psmd7,Psmd5,Mdm4,Mdm2,Psma6 R-MMU-69563 p53-Dependent G1 DNA Damage Response 0.993854755810702 -0.00616420391705057 62 7 0.00352112676056338 1988 8688 17246,26443,17248,66998,17463,26440,12447 Mdm2,Psma6,Mdm4,Psmd5,Psmd7,Psma1,Ccne1 R-MMU-212300 PRC2 methylates histones and DNA 0.994249399014756 -0.00576719935541358 43 4 0.00201207243460765 1988 8688 15078,13433,13435,11569 H3f3a,Dnmt1,Dnmt3a,Aebp2 R-MMU-5688426 Deubiquitination 0.994569861021446 -0.00544493577329457 237 39 0.0196177062374245 1988 8688 12006,66998,74996,13982,235441,22030,109359,12021,17248,17425,17127,21812,18970,227195,229603,27401,93841,14462,19211,225280,18035,17246,74256,22258,22217,107976,21951,26440,67952,17463,327799,15251,77125,329908,107607,50873,66313,26409,26443 Axin2,Psmd5,Usp47,Esr1,Usp3,Traf2,Abraxas2,Bard1,Mdm4,Foxk1,Smad3,Tgfbr1,Polb,Ino80d,Otud7b,Skp2,Uchl4,Gata3,Pten,Ino80c,Nfkbia,Mdm2,Cyld,Usp4,Usp12,Babam2,Tnks,Psma1,Tomm20,Psmd7,Usp44,Hif1a,Il33,Usp24,Nod1,Prkn,Smurf2,Map3k7,Psma6 R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence 0.995274892858011 -0.00473630575108502 44 4 0.00201207243460765 1988 8688 15364,17535,16906,12447 Hmga2,Mre11a,Lmnb1,Ccne1 R-MMU-176187 Activation of ATR in response to replication stress 0.995347058557615 -0.00466380007055191 37 3 0.00150905432595573 1988 8688 17219,69263,12545 Mcm6,Rfc3,Cdc7 R-MMU-3214841 PKMTs methylate histone lysines 0.995473437892566 -0.00453683801109284 70 8 0.00402414486921529 1988 8688 11569,69726,208266,226830,225888,18033,214162,14013 Aebp2,Smyd3,Dot1l,Smyd2,Kmt5b,Nfkb1,Kmt2a,Mecom R-MMU-350562 Regulation of ornithine decarboxylase (ODC) 0.995502277845601 -0.00450786733826249 51 5 0.00251509054325956 1988 8688 26440,17463,18247,66998,26443 Psma1,Psmd7,Oaz2,Psmd5,Psma6 R-MMU-69229 Ubiquitin-dependent degradation of Cyclin D1 0.995502277845601 -0.00450786733826249 51 5 0.00251509054325956 1988 8688 26440,17463,66998,12443,26443 Psma1,Psmd7,Psmd5,Ccnd1,Psma6 R-MMU-75815 Ubiquitin-dependent degradation of Cyclin D 0.995502277845601 -0.00450786733826249 51 5 0.00251509054325956 1988 8688 17463,26440,66998,12443,26443 Psmd7,Psma1,Psmd5,Ccnd1,Psma6 R-MMU-69615 G1/S DNA Damage Checkpoints 0.995618846628972 -0.00439077874724618 64 7 0.00352112676056338 1988 8688 17463,26440,12447,66998,26443,17246,17248 Psmd7,Psma1,Ccne1,Psmd5,Psma6,Mdm2,Mdm4 R-MMU-2467813 Separation of Sister Chromatids 0.99563704322492 -0.0043725022454251 166 25 0.0125754527162978 1988 8688 16563,56430,100710,76707,244495,108000,56150,226849,66998,17120,19357,83431,434233,226747,73699,76499,67629,26951,26443,16319,26440,17463,12237,26932,56317 Kif2a,Clip1,Pds5b,Clasp1,Sgo2b,Cenpf,Mad2l1,Ppp2r5a,Psmd5,Mad1l1,Rad21,Ndel1,Ppp1ccb,Ahctf1,Ppp2r1b,Clasp2,Spc24,Zw10,Psma6,Incenp,Psma1,Psmd7,Bub3,Ppp2r5e,Anapc7 R-MMU-68882 Mitotic Anaphase 0.995949595592932 -0.004058629512514 172 26 0.0130784708249497 1988 8688 12237,17463,26440,56317,26932,76499,73699,226747,26443,16319,26951,67629,66998,226849,434233,16905,83431,19357,17120,244495,108000,100710,16563,56430,76707,56150 Bub3,Psmd7,Psma1,Anapc7,Ppp2r5e,Clasp2,Ppp2r1b,Ahctf1,Psma6,Incenp,Zw10,Spc24,Psmd5,Ppp2r5a,Ppp1ccb,Lmna,Ndel1,Rad21,Mad1l1,Sgo2b,Cenpf,Pds5b,Kif2a,Clip1,Clasp1,Mad2l1 R-MMU-72689 Formation of a pool of free 40S subunits 0.996205741396022 -0.00380147506301249 95 12 0.00603621730382294 1988 8688 20090,66475,68436,267019,19921,100502825,68135,56040,19946,19944,19981,14109 Rps29,Rps23,Rpl34,Rps15a,Rpl19,Rpl37rt,Eif3h,Rplp1,Rpl30,Rpl29,Rpl37a,Fau R-MMU-69620 Cell Cycle Checkpoints 0.996241900836475 -0.00376517856046986 178 27 0.0135814889336016 1988 8688 26443,12447,22628,225182,70620,12545,56317,17463,26440,21975,223970,12237,27223,12144,69263,17248,107976,56150,22630,12021,22631,17535,17120,17246,17219,66998,22390 Psma6,Ccne1,Ywhag,Rbbp8,Ube2v2,Cdc7,Anapc7,Psmd7,Psma1,Top3a,Rmi2,Bub3,Trp53bp1,Blm,Rfc3,Mdm4,Babam2,Mad2l1,Ywhaq,Bard1,Ywhaz,Mre11a,Mad1l1,Mdm2,Mcm6,Psmd5,Wee1 R-MMU-2555396 Mitotic Metaphase and Anaphase 0.996382784640683 -0.0036237733018979 173 26 0.0130784708249497 1988 8688 26932,56317,26440,17463,12237,67629,26951,26443,16319,226747,73699,76499,17120,19357,83431,16905,434233,226849,66998,56150,56430,16563,100710,76707,108000,244495 Ppp2r5e,Anapc7,Psma1,Psmd7,Bub3,Spc24,Zw10,Psma6,Incenp,Ahctf1,Ppp2r1b,Clasp2,Mad1l1,Rad21,Ndel1,Lmna,Ppp1ccb,Ppp2r5a,Psmd5,Mad2l1,Clip1,Kif2a,Pds5b,Clasp1,Cenpf,Sgo2b R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome 0.996552844109066 -0.00345311102225144 59 6 0.00301810865191147 1988 8688 66998,26440,17463,93687,26443,14634 Psmd5,Psma1,Psmd7,Csnk1a1,Psma6,Gli3 R-MMU-453276 Regulation of mitotic cell cycle 0.996647170727753 -0.00335846259955889 84 10 0.00503018108651911 1988 8688 26443,56150,27401,229776,18005,56317,17463,26440,66998,12237 Psma6,Mad2l1,Skp2,Cdc14a,Nek2,Anapc7,Psmd7,Psma1,Psmd5,Bub3 R-MMU-174143 APC/C-mediated degradation of cell cycle proteins 0.996647170727753 -0.00335846259955889 84 10 0.00503018108651911 1988 8688 56317,18005,12237,66998,26440,17463,56150,26443,229776,27401 Anapc7,Nek2,Bub3,Psmd5,Psma1,Psmd7,Mad2l1,Psma6,Cdc14a,Skp2 R-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.996734294336141 -0.00327104971851239 22 1 0.000503018108651912 1988 8688 110821 Pcca R-MMU-975298 Ligand-gated ion channel transport 0.996734294336141 -0.00327104971851239 22 1 0.000503018108651912 1988 8688 14658 Glrb R-MMU-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.996734294336141 -0.00327104971851239 22 1 0.000503018108651912 1988 8688 56317 Anapc7 R-MMU-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.996747341752011 -0.00325795963969345 72 8 0.00402414486921529 1988 8688 17463,26440,66998,12237,18005,56317,26443,56150 Psmd7,Psma1,Psmd5,Bub3,Nek2,Anapc7,Psma6,Mad2l1 R-MMU-6807505 RNA polymerase II transcribes snRNA genes 0.996747341752011 -0.00325795963969345 72 8 0.00402414486921529 1988 8688 63856,75627,101861,72949,18130,218333,13716,192657 Taf8,Snapc1,Ints4,Ccnt2,Ints6,Ice1,Ell,Ell2 R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.996907364424778 -0.00309742765527772 108 14 0.00704225352112676 1988 8688 267019,100502825,19921,68436,19704,66475,20090,19944,14109,19981,19946,66441,52830,56040 Rps15a,Rpl37rt,Rpl19,Rpl34,Upf1,Rps23,Rps29,Rpl29,Fau,Rpl37a,Rpl30,Magohb,Pnrc2,Rplp1 R-MMU-927802 Nonsense-Mediated Decay (NMD) 0.996907364424778 -0.00309742765527772 108 14 0.00704225352112676 1988 8688 14109,19944,19981,66441,19946,52830,56040,267019,19921,100502825,68436,19704,66475,20090 Fau,Rpl29,Rpl37a,Magohb,Rpl30,Pnrc2,Rplp1,Rps15a,Rpl19,Rpl37rt,Rpl34,Upf1,Rps23,Rps29 R-MMU-166658 Complement cascade 0.996956839854421 -0.00304779997296424 39 3 0.00150905432595573 1988 8688 11537,239447,17221 Cfd,Colec10,Cd46 R-MMU-3247509 Chromatin modifying enzymes 0.997107522367091 -0.00289666893044433 191 29 0.0145875251509054 1988 8688 193796,15078,66993,319177,13435,11569,104263,228829,208266,67014,225888,18033,54169,14013,71974,18505,70088,269424,99982,338523,239985,76719,320595,12443,69726,216850,214162,20588,226830 Kdm4b,H3f3a,Smarcd3,Hist1h2ba,Dnmt3a,Aebp2,Kdm3a,Phf20,Dot1l,Riox2,Kmt5b,Nfkb1,Kat6b,Mecom,Prmt3,Pax3,Meaf6,Jade1,Kdm1a,Kdm7a,Arid1b,Kansl1,Phf8,Ccnd1,Smyd3,Kdm6b,Kmt2a,Smarcc1,Smyd2 R-MMU-4839726 Chromatin organization 0.997107522367091 -0.00289666893044433 191 29 0.0145875251509054 1988 8688 226830,20588,214162,216850,320595,12443,69726,239985,76719,269424,99982,338523,70088,54169,71974,18505,14013,225888,67014,18033,228829,208266,319177,104263,11569,13435,193796,15078,66993 Smyd2,Smarcc1,Kmt2a,Kdm6b,Phf8,Ccnd1,Smyd3,Arid1b,Kansl1,Jade1,Kdm1a,Kdm7a,Meaf6,Kat6b,Prmt3,Pax3,Mecom,Kmt5b,Riox2,Nfkb1,Phf20,Dot1l,Hist1h2ba,Kdm3a,Aebp2,Dnmt3a,Kdm4b,H3f3a,Smarcd3 R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.997399662053894 -0.00260372469722912 47 4 0.00201207243460765 1988 8688 26443,66998,17463,26440 Psma6,Psmd5,Psmd7,Psma1 R-MMU-6781823 Formation of TC-NER Pre-Incision Complex 0.997446056529706 -0.0025572103473842 54 5 0.00251509054325956 1988 8688 319955,13871,17420,108679,71101 Ercc6,Ercc2,Mnat1,Cops8,Uvssa R-MMU-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.997483454619963 -0.00251971720283706 23 1 0.000503018108651912 1988 8688 13109 Cyp2j5 R-MMU-5358346 Hedgehog ligand biogenesis 0.997600357861322 -0.00240252589411972 61 6 0.00301810865191147 1988 8688 20338,226861,26443,17463,26440,66998 Sel1l,Hhat,Psma6,Psmd7,Psma1,Psmd5 R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.997611706431364 -0.00239115009076951 104 13 0.00653923541247485 1988 8688 14109,19981,19944,19946,56040,68135,67204,100502825,19921,267019,68436,66475,20090 Fau,Rpl37a,Rpl29,Rpl30,Rplp1,Eif3h,Eif2s2,Rpl37rt,Rpl19,Rps15a,Rpl34,Rps23,Rps29 R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.997674680691741 -0.00232802706161065 74 8 0.00402414486921529 1988 8688 56150,26443,18005,56317,26440,17463,12237,66998 Mad2l1,Psma6,Nek2,Anapc7,Psma1,Psmd7,Bub3,Psmd5 R-MMU-73762 RNA Polymerase I Transcription Initiation 0.997874393181617 -0.00212786912697722 48 4 0.00201207243460765 1988 8688 20018,17420,13871,319955 Polr1d,Mnat1,Ercc2,Ercc6 R-MMU-72187 mRNA 3'-end processing 0.997890549459979 -0.00211167856463501 55 5 0.00251509054325956 1988 8688 71713,20383,66441,73666,64340 Cdc40,Srsf3,Magohb,Thoc3,Dhx38 R-MMU-453274 Mitotic G2-G2/M phases 0.997942117398549 -0.00206000295130473 167 24 0.0120724346076459 1988 8688 26443,73738,73699,13191,22628,18005,17420,214444,21664,26440,17463,103583,71648,13557,76707,15516,77744,101706,99100,51885,22390,19088,66998,27373 Psma6,Haus7,Ppp2r1b,Dctn1,Ywhag,Nek2,Mnat1,Cdk5rap2,Phlda1,Psma1,Psmd7,Fbxw11,Optn,E2f3,Clasp1,Hsp90ab1,Bora,Numa1,Cep152,Tubgcp4,Wee1,Prkar2b,Psmd5,Csnk1e R-MMU-73728 RNA Polymerase I Promoter Opening 0.997989818629497 -0.00201220449676255 33 2 0.00100603621730382 1988 8688 17191,15078 Mbd2,H3f3a R-MMU-211981 Xenobiotics 0.99801880600142 -0.00198315915941576 41 3 0.00150905432595573 1988 8688 56448,11622,11864 Cyp2d22,Ahr,Arnt2 R-MMU-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.998037528156571 -0.00196440001436412 75 8 0.00402414486921529 1988 8688 26440,17463,12237,66998,18005,56317,56150,26443 Psma1,Psmd7,Bub3,Psmd5,Nek2,Anapc7,Mad2l1,Psma6 R-MMU-211945 Phase 1 - Functionalization of compounds 0.99806817539732 -0.00193369298246989 151 21 0.0105633802816901 1988 8688 13082,232174,15516,66427,21391,56050,56448,11622,19224,14148,13075,20181,19223,13074,66112,13123,228608,13070,18105,13109,11864 Cyp26a1,Cyp26b1,Hsp90ab1,Cyb5b,Tbxas1,Cyp39a1,Cyp2d22,Ahr,Ptgs1,Fdx1,Cyp19a1,Rxra,Ptgis,Cyp17a1,Marc1,Cyp7b1,Smox,Cyp11a1,Nqo2,Cyp2j5,Arnt2 R-MMU-73894 DNA Repair 0.998207539006779 -0.00179406937368748 269 43 0.0216297786720322 1988 8688 14048,17535,16647,56626,26419,14088,12021,14049,319955,330554,26383,232314,18970,13870,20610,227195,193796,225182,70620,108679,17420,57434,19363,13871,225280,18972,54125,11545,22596,27223,67196,12144,107976,69263,76843,21975,223970,71101,27015,19359,217365,216835,67030 Eya1,Mre11a,Kpna2,Poll,Mapk8,Fancc,Bard1,Eya2,Ercc6,Fan1,Fto,Ppp4r2,Polb,Ercc1,Sumo3,Ino80d,Kdm4b,Rbbp8,Ube2v2,Cops8,Mnat1,Xrcc2,Rad51b,Ercc2,Ino80c,Pold2,Polm,Parp1,Xrcc5,Trp53bp1,Ube2t,Blm,Babam2,Rfc3,Dtl,Top3a,Rmi2,Uvssa,Polk,Rad23b,Nploc4,Usp43,Fancl R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.998221876332851 -0.00177970640551786 106 13 0.00653923541247485 1988 8688 19981,19944,14109,19946,68135,56040,67204,100502825,19921,267019,68436,66475,20090 Rpl37a,Rpl29,Fau,Rpl30,Eif3h,Rplp1,Eif2s2,Rpl37rt,Rpl19,Rps15a,Rpl34,Rps23,Rps29 R-MMU-69481 G2/M Checkpoints 0.998422925746212 -0.00157831914441815 147 20 0.0100603621730382 1988 8688 22628,26443,17463,26440,21975,223970,225182,12545,70620,22630,12021,22631,27223,12144,69263,107976,66998,22390,17535,17219 Ywhag,Psma6,Psmd7,Psma1,Top3a,Rmi2,Rbbp8,Cdc7,Ube2v2,Ywhaq,Bard1,Ywhaz,Trp53bp1,Blm,Rfc3,Babam2,Psmd5,Wee1,Mre11a,Mcm6 R-MMU-5389840 Mitochondrial translation elongation 0.998532040516535 -0.00146903799158727 83 9 0.0045271629778672 1988 8688 66845,64659,59054,94062,68537,66230,67270,121022,67840 Mrpl33,Mrps14,Mrps30,Mrpl3,Mrpl13,Mrps28,Mrpl42,Mrps6,Mrpl57 R-MMU-4641258 Degradation of DVL 0.998566096607246 -0.00143493241602129 57 5 0.00251509054325956 1988 8688 13542,26443,17463,26440,66998 Dvl1,Psma6,Psmd7,Psma1,Psmd5 R-MMU-5610780 Degradation of GLI1 by the proteasome 0.998566096607246 -0.00143493241602129 57 5 0.00251509054325956 1988 8688 26443,17463,18222,26440,66998 Psma6,Psmd7,Numb,Psma1,Psmd5 R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6 0.998584602917902 -0.00141639970273013 50 4 0.00201207243460765 1988 8688 66998,17463,26440,26443 Psmd5,Psmd7,Psma1,Psma6 R-MMU-3214847 HATs acetylate histones 0.998607146621862 -0.0013938243000771 77 8 0.00402414486921529 1988 8688 76719,319177,228829,15078,269424,70088,18505,54169 Kansl1,Hist1h2ba,Phf20,H3f3a,Jade1,Meaf6,Pax3,Kat6b R-MMU-69275 G2/M Transition 0.998663479470837 -0.00133741446932683 165 23 0.011569416498994 1988 8688 15516,76707,103583,71648,99100,51885,27373,66998,19088,22390,101706,77744,13191,73699,73738,22628,26443,17463,26440,18005,21664,17420,214444 Hsp90ab1,Clasp1,Fbxw11,Optn,Cep152,Tubgcp4,Csnk1e,Psmd5,Prkar2b,Wee1,Numa1,Bora,Dctn1,Ppp2r1b,Haus7,Ywhag,Psma6,Psmd7,Psma1,Nek2,Phlda1,Mnat1,Cdk5rap2 R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.998713570743039 -0.00128725741740046 71 7 0.00352112676056338 1988 8688 56150,56317,26443,26440,17463,12237,66998 Mad2l1,Anapc7,Psma6,Psma1,Psmd7,Bub3,Psmd5 R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 0.99874129396546 -0.00125949887034873 35 2 0.00100603621730382 1988 8688 99982,15078 Kdm1a,H3f3a R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.99881982889612 -0.00118086805419862 58 5 0.00251509054325956 1988 8688 26443,26440,17463,15516,66998 Psma6,Psma1,Psmd7,Hsp90ab1,Psmd5 R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.99881982889612 -0.00118086805419862 58 5 0.00251509054325956 1988 8688 17463,26440,66998,103583,26443 Psmd7,Psma1,Psmd5,Fbxw11,Psma6 R-MMU-5676590 NIK-->noncanonical NF-kB signaling 0.99881982889612 -0.00118086805419862 58 5 0.00251509054325956 1988 8688 17463,26440,66998,103583,26443 Psmd7,Psma1,Psmd5,Fbxw11,Psma6 R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.998846928463174 -0.00115373683528402 51 4 0.00201207243460765 1988 8688 66998,17463,26440,26443 Psmd5,Psmd7,Psma1,Psma6 R-MMU-977606 Regulation of Complement cascade 0.998848673748458 -0.00115198953676481 26 1 0.000503018108651912 1988 8688 17221 Cd46 R-MMU-5419276 Mitochondrial translation termination 0.998950717360023 -0.00104983352239437 85 9 0.0045271629778672 1988 8688 121022,67270,67840,66230,59054,94062,68537,66845,64659 Mrps6,Mrpl42,Mrpl57,Mrps28,Mrps30,Mrpl3,Mrpl13,Mrpl33,Mrps14 R-MMU-69206 G1/S Transition 0.999026780328142 -0.000973693557611477 110 13 0.00653923541247485 1988 8688 12443,12545,17219,17420,17463,26440,66998,22390,18974,26443,73699,12447,27401 Ccnd1,Cdc7,Mcm6,Mnat1,Psmd7,Psma1,Psmd5,Wee1,Pole2,Psma6,Ppp2r1b,Ccne1,Skp2 R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.99906162451356 -0.000938816036339347 52 4 0.00201207243460765 1988 8688 26443,66998,17463,26440 Psma6,Psmd5,Psmd7,Psma1 R-MMU-69613 p53-Independent G1/S DNA damage checkpoint 0.99906162451356 -0.000938816036339347 52 4 0.00201207243460765 1988 8688 66998,17463,26440,26443 Psmd5,Psmd7,Psma1,Psma6 R-MMU-69610 p53-Independent DNA Damage Response 0.99906162451356 -0.000938816036339347 52 4 0.00201207243460765 1988 8688 26443,26440,17463,66998 Psma6,Psma1,Psmd7,Psmd5 R-MMU-5368287 Mitochondrial translation 0.9991143283068 -0.000886064132105718 86 9 0.0045271629778672 1988 8688 67840,121022,67270,66230,68537,94062,59054,64659,66845 Mrpl57,Mrps6,Mrpl42,Mrps28,Mrpl13,Mrpl3,Mrps30,Mrps14,Mrpl33 R-MMU-6803157 Antimicrobial peptides 0.999203160814725 -0.000797156830370799 60 5 0.00251509054325956 1988 8688 329547,22072,11927,12652,24088 Bpi,Prss2,Atox1,Chga,Tlr2 R-MMU-68867 Assembly of the pre-replicative complex 0.999213597411335 -0.000786711965387846 67 6 0.00301810865191147 1988 8688 17219,13557,26443,26440,17463,66998 Mcm6,E2f3,Psma6,Psma1,Psmd7,Psmd5 R-MMU-72613 Eukaryotic Translation Initiation 0.999284343990333 -0.000715912213672138 112 13 0.00653923541247485 1988 8688 100502825,19921,267019,68436,66475,20090,19981,19944,14109,19946,56040,68135,67204 Rpl37rt,Rpl19,Rps15a,Rpl34,Rps23,Rps29,Rpl37a,Rpl29,Fau,Rpl30,Rplp1,Eif3h,Eif2s2 R-MMU-72737 Cap-dependent Translation Initiation 0.999284343990333 -0.000715912213672138 112 13 0.00653923541247485 1988 8688 56040,68135,67204,19981,14109,19944,19946,66475,20090,19921,100502825,267019,68436 Rplp1,Eif3h,Eif2s2,Rpl37a,Fau,Rpl29,Rpl30,Rps23,Rps29,Rpl19,Rpl37rt,Rps15a,Rpl34 R-MMU-69242 S Phase 0.999290660968887 -0.000709590731077862 124 15 0.00754527162977867 1988 8688 17219,17420,12443,19357,18972,66998,22390,17463,26440,26443,69263,18974,100710,27401,12447 Mcm6,Mnat1,Ccnd1,Rad21,Pold2,Psmd5,Wee1,Psmd7,Psma1,Psma6,Rfc3,Pole2,Pds5b,Skp2,Ccne1 R-MMU-72766 Translation 0.999302061912795 -0.000698181759376909 130 16 0.00804828973843058 1988 8688 67204,19981,19944,14109,20090,66475,68436,100502825,267019,56040,68135,19946,20813,217337,67768,19921 Eif2s2,Rpl37a,Rpl29,Fau,Rps29,Rps23,Rpl34,Rpl37rt,Rps15a,Rplp1,Eif3h,Rpl30,Srp14,Srp68,N6amt1,Rpl19 R-MMU-391251 Protein folding 0.999316529910559 -0.000683703761600832 28 1 0.000503018108651912 1988 8688 20698 Sphk1 R-MMU-390466 Chaperonin-mediated protein folding 0.999316529910559 -0.000683703761600832 28 1 0.000503018108651912 1988 8688 20698 Sphk1 R-MMU-75953 RNA Polymerase II Transcription Initiation 0.999334328123664 -0.000665893534232667 46 3 0.00150905432595573 1988 8688 17420,228980,13871 Mnat1,Taf4,Ercc2 R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.999334328123664 -0.000665893534232667 46 3 0.00150905432595573 1988 8688 13871,228980,17420 Ercc2,Taf4,Mnat1 R-MMU-73776 RNA Polymerase II Promoter Escape 0.999334328123664 -0.000665893534232667 46 3 0.00150905432595573 1988 8688 13871,228980,17420 Ercc2,Taf4,Mnat1 R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.999334328123664 -0.000665893534232667 46 3 0.00150905432595573 1988 8688 228980,17420,13871 Taf4,Mnat1,Ercc2 R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1 0.999380407278887 -0.000619784748005827 54 4 0.00201207243460765 1988 8688 26443,66998,26440,17463 Psma6,Psmd5,Psma1,Psmd7 R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.999423817553643 -0.000576348503251515 143 18 0.00905432595573441 1988 8688 20917,20181,68194,28080,20916,68263,269951,106557,14651,18115,68493,22228,11957,381511,76826,22229,26940,20501 Suclg2,Rxra,Ndufb4,Atp5o,Sucla2,Pdhb,Idh2,Ldhal6b,Hagh,Nnt,Ndufaf4,Ucp2,Atp5j,Pdp1,Nubpl,Ucp3,Ecsit,Slc16a1 R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.999464215231587 -0.000535928352360939 62 5 0.00251509054325956 1988 8688 66998,26440,17463,56317,26443 Psmd5,Psma1,Psmd7,Anapc7,Psma6 R-MMU-453279 Mitotic G1-G1/S phases 0.999479325111427 -0.000520810486812872 132 16 0.00804828973843058 1988 8688 17420,12571,12545,26440,17463,26443,18974,27401,12447,73699,17219,13548,12443,22390,66998,13557 Mnat1,Cdk6,Cdc7,Psma1,Psmd7,Psma6,Pole2,Skp2,Ccne1,Ppp2r1b,Mcm6,Dyrk1a,Ccnd1,Wee1,Psmd5,E2f3 R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase 0.999482193958988 -0.000517940148856956 76 7 0.00352112676056338 1988 8688 66998,12237,17463,26440,26443,56317,56150 Psmd5,Bub3,Psmd7,Psma1,Psma6,Anapc7,Mad2l1 R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.999497258881726 -0.000502867534961873 55 4 0.00201207243460765 1988 8688 26443,66998,26440,17463 Psma6,Psmd5,Psma1,Psmd7 R-MMU-6805567 Keratinization 0.99951411785282 -0.000486000226160105 150 19 0.00955734406438632 1988 8688 75706,76560,67451,13512,69664,16660,16480,16666,12336,114566,19143,13505,18550,109620,71529,18772,16693,18553,13511 Krt24,Prss8,Pkp2,Dsg3,Krtap1-5,Krt31,Jup,Krt16,Capns1,Krt82,St14,Dsc1,Furin,Dsp,Kazn,Pkp1,Krtap11-1,Pcsk6,Dsg2 R-MMU-68874 M/G1 Transition 0.99951502866957 -0.000485088967060957 83 8 0.00402414486921529 1988 8688 18974,13557,26443,26440,17463,66998,12545,17219 Pole2,E2f3,Psma6,Psma1,Psmd7,Psmd5,Cdc7,Mcm6 R-MMU-69002 DNA Replication Pre-Initiation 0.99951502866957 -0.000485088967060957 83 8 0.00402414486921529 1988 8688 26443,13557,18974,17219,12545,66998,26440,17463 Psma6,E2f3,Pole2,Mcm6,Cdc7,Psmd5,Psma1,Psmd7 R-MMU-3214858 RMTs methylate histone arginines 0.999556374025378 -0.000443724405736635 70 6 0.00301810865191147 1988 8688 66993,71974,20588,239985,13435,12443 Smarcd3,Prmt3,Smarcc1,Arid1b,Dnmt3a,Ccnd1 R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.999634171270377 -0.000365895661277212 71 6 0.00301810865191147 1988 8688 26443,56317,66998,17463,27401,26440 Psma6,Anapc7,Psmd5,Psmd7,Skp2,Psma1 R-MMU-109688 Cleavage of Growing Transcript in the Termination Region 0.99964115458943 -0.000358909810991137 64 5 0.00251509054325956 1988 8688 64340,73666,66441,20383,71713 Dhx38,Thoc3,Magohb,Srsf3,Cdc40 R-MMU-73856 RNA Polymerase II Transcription Termination 0.99964115458943 -0.000358909810991137 64 5 0.00251509054325956 1988 8688 73666,64340,71713,20383,66441 Thoc3,Dhx38,Cdc40,Srsf3,Magohb R-MMU-1236975 Antigen processing-Cross presentation 0.999714442398022 -0.000285598381313531 99 10 0.00503018108651911 1988 8688 12491,17969,26443,240028,66998,17970,16410,17463,16419,26440 Cd36,Ncf1,Psma6,Lnpep,Psmd5,Ncf2,Itgav,Psmd7,Itgb5,Psma1 R-MMU-1852241 Organelle biogenesis and maintenance 0.999719260201062 -0.000280779213732756 276 41 0.0206237424547284 1988 8688 16570,13191,73916,73738,12589,27078,108099,214444,231214,76260,66845,66482,59054,68537,382090,18763,13196,121022,319845,27373,72938,68642,94062,22628,18005,75465,67270,211446,238799,217935,64659,26416,76707,264134,66230,53869,333329,99100,213081,67840,19088 Kif3c,Dctn1,Ift57,Haus7,Ift81,B9d1,Prkag2,Cdk5rap2,Cc2d2a,Ttc8,Mrpl33,Exoc2,Mrps30,Mrpl13,Cep162,Pkd1,Asap1,Mrps6,Bbs9,Csnk1e,Hspb11,Tmem216,Mrpl3,Ywhag,Nek2,Dynlrb2,Mrpl42,Exoc3,Tnpo1,Wdr60,Mrps14,Mapk14,Clasp1,Ttc26,Mrps28,Rab11a,Cngb1,Cep152,Wdr19,Mrpl57,Prkar2b R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex 0.999732877668497 -0.000267158015027276 58 4 0.00201207243460765 1988 8688 66998,26440,17463,26443 Psmd5,Psma1,Psmd7,Psma6 R-MMU-6799198 Complex I biogenesis 0.999732877668497 -0.000267158015027276 58 4 0.00201207243460765 1988 8688 68194,26940,68493,76826 Ndufb4,Ecsit,Ndufaf4,Nubpl R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin 0.999760549114322 -0.000239479558618948 66 5 0.00251509054325956 1988 8688 26440,17463,66998,56317,26443 Psma1,Psmd7,Psmd5,Anapc7,Psma6 R-MMU-5689603 UCH proteinases 0.999779943161452 -0.000220081054606332 94 9 0.0045271629778672 1988 8688 17463,26440,66998,227195,225280,93841,12021,26443,17425 Psmd7,Psma1,Psmd5,Ino80d,Ino80c,Uchl4,Bard1,Psma6,Foxk1 R-MMU-68886 M Phase 0.999811926888095 -0.000188090799870821 247 35 0.0176056338028169 1988 8688 108000,76707,100710,434233,16905,19357,83431,59021,26443,19069,71805,17463,14245,26440,56150,18750,244495,56430,16563,218210,320595,17120,66998,226849,16319,26951,67629,76499,73699,226747,56317,244329,26932,12237,59126 Cenpf,Clasp1,Pds5b,Ppp1ccb,Lmna,Rad21,Ndel1,Rab2a,Psma6,Nup88,Nup93,Psmd7,Lpin1,Psma1,Mad2l1,Prkca,Sgo2b,Clip1,Kif2a,Nup153,Phf8,Mad1l1,Psmd5,Ppp2r5a,Incenp,Zw10,Spc24,Clasp2,Ppp2r1b,Ahctf1,Anapc7,Mcph1,Ppp2r5e,Bub3,Nek6 R-MMU-69304 Regulation of DNA replication 0.999832394165191 -0.000167619882236703 75 6 0.00301810865191147 1988 8688 66998,17463,26440,17219,26443,13557 Psmd5,Psmd7,Psma1,Mcm6,Psma6,E2f3 R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.999840777560783 -0.000159235116454987 68 5 0.00251509054325956 1988 8688 12571,56317,20111,15078,18033 Cdk6,Anapc7,Rps6ka1,H3f3a,Nfkb1 R-MMU-1236977 Endosomal/Vacuolar pathway 0.999857135592969 -0.000142874613122893 34 1 0.000503018108651912 1988 8688 240028 Lnpep R-MMU-5578749 Transcriptional regulation by small RNAs 0.999862411305867 -0.000137598160326124 76 6 0.00301810865191147 1988 8688 15078,239528,218210,233833,19069,71805 H3f3a,Ago2,Nup153,Tnrc6a,Nup88,Nup93 R-MMU-72163 mRNA Splicing - Major Pathway 0.999871363432059 -0.000128644842333704 171 21 0.0105633802816901 1988 8688 68183,66373,229279,66642,67465,68981,66070,67285,15387,71713,50783,68592,64340,107686,71702,66441,78651,76522,20383,67678,15481 Bcas2,Lsm5,Hnrnpa3,Ctnnbl1,Sf3a1,Snrpa1,Cwc15,Cwc27,Hnrnpk,Cdc40,Lsm4,Syf2,Dhx38,Snrpd2,Cdc5l,Magohb,Lsm6,Lsm8,Srsf3,Lsm3,Hspa8 R-MMU-1500620 Meiosis 0.999876473977987 -0.000123533651980211 123 13 0.00653923541247485 1988 8688 19357,64009,319177,16905,16906,21975,223697,15078,12144,26972,77053,26914,51788 Rad21,Syne1,Hist1h2ba,Lmna,Lmnb1,Top3a,Sun2,H3f3a,Blm,Spo11,Sun1,H2afy,H2afz R-MMU-69052 Switching of origins to a post-replicative state 0.999894476147405 -0.00010552942062841 70 5 0.00251509054325956 1988 8688 17219,26443,66998,26440,17463 Mcm6,Psma6,Psmd5,Psma1,Psmd7 R-MMU-68949 Orc1 removal from chromatin 0.999894476147405 -0.00010552942062841 70 5 0.00251509054325956 1988 8688 26440,17463,66998,17219,26443 Psma1,Psmd7,Psmd5,Mcm6,Psma6 R-MMU-5334118 DNA methylation 0.99990751271794 -9.24915592719416e-05 78 6 0.00301810865191147 1988 8688 13435,319177,26914,13433,15078,51788 Dnmt3a,Hist1h2ba,H2afy,Dnmt1,H3f3a,H2afz R-MMU-1221632 Meiotic synapsis 0.999916044704136 -8.39588203071194e-05 106 10 0.00503018108651911 1988 8688 16906,223697,15078,19357,64009,319177,16905,26914,51788,77053 Lmnb1,Sun2,H3f3a,Rad21,Syne1,Hist1h2ba,Lmna,H2afy,H2afz,Sun1 R-MMU-1221633 Meiotic Synapsis 0.999916044704136 -8.39588203071194e-05 106 10 0.00503018108651911 1988 8688 16906,15078,223697,19357,64009,319177,16905,26914,51788,77053 Lmnb1,H3f3a,Sun2,Rad21,Syne1,Hist1h2ba,Lmna,H2afy,H2afz,Sun1 R-MMU-69306 DNA Replication 0.999916044704136 -8.39588203071194e-05 106 10 0.00503018108651911 1988 8688 26443,13557,69263,18974,17219,18972,12545,66998,17463,26440 Psma6,E2f3,Rfc3,Pole2,Mcm6,Pold2,Cdc7,Psmd5,Psmd7,Psma1 R-MMU-72172 mRNA Splicing 0.999918103160524 -8.19001932051426e-05 180 22 0.0110663983903421 1988 8688 15387,50783,71713,66070,67285,66642,229279,67465,22184,68981,68183,66373,20383,67678,15481,78651,76522,71702,66441,68592,64340,107686 Hnrnpk,Lsm4,Cdc40,Cwc15,Cwc27,Ctnnbl1,Hnrnpa3,Sf3a1,Zrsr2,Snrpa1,Bcas2,Lsm5,Srsf3,Lsm3,Hspa8,Lsm6,Lsm8,Cdc5l,Magohb,Syf2,Dhx38,Snrpd2 R-MMU-69300 Removal of licensing factors from origins 0.999930284566211 -6.9717864023037e-05 72 5 0.00251509054325956 1988 8688 66998,17463,26440,26443,17219 Psmd5,Psmd7,Psma1,Psma6,Mcm6 R-MMU-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.999934912759073 -6.50893591934142e-05 114 11 0.00553319919517103 1988 8688 15078,13871,17420,17191,75627,20018,78929,319955,66596,67486,208595 H3f3a,Ercc2,Mnat1,Mbd2,Snapc1,Polr1d,Polr3h,Ercc6,Gtf3a,Polr3g,Mterf1b R-MMU-73854 RNA Polymerase I Promoter Clearance 0.99993802929804 -6.19726222232112e-05 80 6 0.00301810865191147 1988 8688 20018,17420,17191,319955,15078,13871 Polr1d,Mnat1,Mbd2,Ercc6,H3f3a,Ercc2 R-MMU-73864 RNA Polymerase I Transcription 0.99994933182079 -5.06694628851116e-05 81 6 0.00301810865191147 1988 8688 15078,319955,13871,20018,17420,17191 H3f3a,Ercc6,Ercc2,Polr1d,Mnat1,Mbd2 R-MMU-427359 SIRT1 negatively regulates rRNA Expression 0.999949716242063 -5.02850222079362e-05 38 1 0.000503018108651912 1988 8688 15078 H3f3a R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.999955595719834 -4.4405266065643e-05 49 2 0.00100603621730382 1988 8688 69608,20334 Sec24d,Sec23a R-MMU-73886 Chromosome Maintenance 0.999961606589538 -3.83941475081526e-05 67 4 0.00201207243460765 1988 8688 69263,18972,18974,66311 Rfc3,Pold2,Pole2,Cenpw R-MMU-73857 RNA Polymerase II Transcription 0.99996370561151 -3.6295047146845e-05 143 15 0.00754527162977867 1988 8688 64340,17420,66441,20924,13871,235497,228980,13716,73666,70122,67655,72949,20383,71713,24116 Dhx38,Mnat1,Magohb,Supt5,Ercc2,Leo1,Taf4,Ell,Thoc3,Mllt3,Ctdp1,Ccnt2,Srsf3,Cdc40,Nelfa R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.999963751354877 -3.62493021207662e-05 97 8 0.00402414486921529 1988 8688 26940,76826,22228,11957,22229,28080,68194,68493 Ecsit,Nubpl,Ucp2,Atp5j,Ucp3,Atp5o,Ndufb4,Ndufaf4 R-MMU-69239 Synthesis of DNA 0.999970065135027 -2.99353130300918e-05 98 8 0.00402414486921529 1988 8688 17219,18972,66998,17463,26440,26443,69263,18974 Mcm6,Pold2,Psmd5,Psmd7,Psma1,Psma6,Rfc3,Pole2 R-MMU-912497 Meiotic Recombination 0.999970649901176 -2.9350529546642e-05 91 7 0.00352112676056338 1988 8688 26914,51788,21975,15078,319177,12144,26972 H2afy,H2afz,Top3a,H3f3a,Hist1h2ba,Blm,Spo11 R-MMU-427413 NoRC negatively regulates rRNA expression 0.999975916121405 -2.40841686159309e-05 92 7 0.00352112676056338 1988 8688 51788,15078,13433,26914,319177,17191,20018 H2afz,H3f3a,Dnmt1,H2afy,Hist1h2ba,Mbd2,Polr1d R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.999977030698995 -2.29695648037403e-05 41 1 0.000503018108651912 1988 8688 66311 Cenpw R-MMU-774815 Nucleosome assembly 0.999977030698995 -2.29695648037403e-05 41 1 0.000503018108651912 1988 8688 66311 Cenpw R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.999983579734877 -1.64203999372634e-05 115 10 0.00503018108651911 1988 8688 271375,16412,16401,80782,68713,74482,71326,17059,16414,74603 Cd200r2,Itgb1,Itga4,Klrb1b,Ifitm1,Ifitm7,Treml1,Klrb1c,Itgb2,Cd200r3 R-MMU-5250924 B-WICH complex positively regulates rRNA expression 0.999985825760303 -1.41743401526848e-05 63 3 0.00150905432595573 1988 8688 15078,319955,20018 H3f3a,Ercc6,Polr1d R-MMU-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0.999989675049111 -1.03250041916396e-05 131 12 0.00603621730382294 1988 8688 26914,218772,51788,16476,17268,18514,17979,15078,20181,15423,13654,319177 H2afy,Rarb,H2afz,Jun,Meis1,Pbx1,Ncoa3,H3f3a,Rxra,Hoxc4,Egr2,Hist1h2ba R-MMU-5619507 Activation of HOX genes during differentiation 0.999989675049111 -1.03250041916396e-05 131 12 0.00603621730382294 1988 8688 17979,18514,16476,51788,17268,26914,218772,319177,13654,15423,20181,15078 Ncoa3,Pbx1,Jun,H2afz,Meis1,H2afy,Rarb,Hist1h2ba,Egr2,Hoxc4,Rxra,H3f3a R-MMU-72165 mRNA Splicing - Minor Pathway 0.999989690536366 -1.03095167765031e-05 55 2 0.00100603621730382 1988 8688 22184,107686 Zrsr2,Snrpd2 R-MMU-611105 Respiratory electron transport 0.999991816980423 -8.18305305795193e-06 74 4 0.00201207243460765 1988 8688 26940,68194,68493,76826 Ecsit,Ndufb4,Ndufaf4,Nubpl R-MMU-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.999993453348198 -6.54667323186292e-06 75 4 0.00201207243460765 1988 8688 51788,15078,26914,319177 H2afz,H3f3a,H2afy,Hist1h2ba R-MMU-573389 NoRC negatively regulates rRNA expression 0.999993492397913 -6.50762326112451e-06 91 6 0.00301810865191147 1988 8688 26914,13433,15078,51788,20018,319177 H2afy,Dnmt1,H3f3a,H2afz,Polr1d,Hist1h2ba R-MMU-5250941 Negative epigenetic regulation of rRNA expression 0.999995168855353 -4.83115631681753e-06 100 7 0.00352112676056338 1988 8688 20018,319177,17191,26914,51788,15078,13433 Polr1d,Hist1h2ba,Mbd2,H2afy,H2afz,H3f3a,Dnmt1 R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA 0.999996432900451 -3.56710591095352e-06 231 27 0.0135814889336016 1988 8688 66373,68183,71805,19069,66642,229279,67465,22184,68981,66070,73666,67285,15387,50783,71713,68592,107686,64340,71702,56488,66441,78651,76522,20383,218210,67678,15481 Lsm5,Bcas2,Nup93,Nup88,Ctnnbl1,Hnrnpa3,Sf3a1,Zrsr2,Snrpa1,Cwc15,Thoc3,Cwc27,Hnrnpk,Lsm4,Cdc40,Syf2,Snrpd2,Dhx38,Cdc5l,Nxt1,Magohb,Lsm6,Lsm8,Srsf3,Nup153,Lsm3,Hspa8 R-MMU-69278 Cell Cycle, Mitotic 0.999996454500964 -3.54550532091821e-06 438 64 0.0321931589537223 1988 8688 22390,99100,434233,16905,101706,76707,13557,69263,17463,26440,71805,26443,27373,77744,17120,244495,16563,218210,71648,56150,12237,21664,214444,17420,244329,13191,12447,226747,27401,67629,19088,51885,18972,83431,19357,108000,15516,100710,14245,12571,19069,18005,22628,59021,18974,66998,226849,17219,13548,12443,320595,56430,18750,103583,59126,56317,12545,26932,76499,229776,73699,73738,16319,26951 Wee1,Cep152,Ppp1ccb,Lmna,Numa1,Clasp1,E2f3,Rfc3,Psmd7,Psma1,Nup93,Psma6,Csnk1e,Bora,Mad1l1,Sgo2b,Kif2a,Nup153,Optn,Mad2l1,Bub3,Phlda1,Cdk5rap2,Mnat1,Mcph1,Dctn1,Ccne1,Ahctf1,Skp2,Spc24,Prkar2b,Tubgcp4,Pold2,Ndel1,Rad21,Cenpf,Hsp90ab1,Pds5b,Lpin1,Cdk6,Nup88,Nek2,Ywhag,Rab2a,Pole2,Psmd5,Ppp2r5a,Mcm6,Dyrk1a,Ccnd1,Phf8,Clip1,Prkca,Fbxw11,Nek6,Anapc7,Cdc7,Ppp2r5e,Clasp2,Cdc14a,Ppp2r1b,Haus7,Incenp,Zw10 R-MMU-211000 Gene Silencing by RNA 0.999998265304037 -1.73469746719443e-06 105 7 0.00352112676056338 1988 8688 71805,233833,19069,192119,218210,239528,15078 Nup93,Tnrc6a,Nup88,Dicer1,Nup153,Ago2,H3f3a R-MMU-212165 Epigenetic regulation of gene expression 0.999999198292647 -8.01707674481685e-07 138 11 0.00553319919517103 1988 8688 26914,51788,319955,214133,13433,15078,20018,319177,11569,13435,17191 H2afy,H2afz,Ercc6,Tet2,Dnmt1,H3f3a,Polr1d,Hist1h2ba,Aebp2,Dnmt3a,Mbd2 R-MMU-5250913 Positive epigenetic regulation of rRNA expression 0.999999826283188 -1.73716827329054e-07 108 6 0.00301810865191147 1988 8688 319955,15078,51788,26914,319177,20018 Ercc6,H3f3a,H2afz,H2afy,Hist1h2ba,Polr1d R-MMU-1640170 Cell Cycle 0.999999934467044 -6.55329580893511e-08 596 87 0.0437625754527163 1988 8688 67629,27401,226747,12447,13191,244329,17420,214444,21664,319177,12237,223697,56150,71648,218210,22631,16563,12021,244495,64009,17120,77744,27373,26443,71805,26440,17463,21975,27223,107976,69263,13557,26914,76707,101706,16905,17246,434233,99100,22390,77053,26951,16319,73738,73699,229776,76499,70620,26932,12545,225182,56317,59126,103583,17248,18750,22630,56430,13548,12443,17535,320595,17219,226849,66311,66998,18974,26972,59021,51788,22628,18005,12571,19069,16906,14245,15078,223970,12144,100710,15516,108000,18972,83431,19357,51885,19088 Spc24,Skp2,Ahctf1,Ccne1,Dctn1,Mcph1,Mnat1,Cdk5rap2,Phlda1,Hist1h2ba,Bub3,Sun2,Mad2l1,Optn,Nup153,Ywhaz,Kif2a,Bard1,Sgo2b,Syne1,Mad1l1,Bora,Csnk1e,Psma6,Nup93,Psma1,Psmd7,Top3a,Trp53bp1,Babam2,Rfc3,E2f3,H2afy,Clasp1,Numa1,Lmna,Mdm2,Ppp1ccb,Cep152,Wee1,Sun1,Zw10,Incenp,Haus7,Ppp2r1b,Cdc14a,Clasp2,Ube2v2,Ppp2r5e,Cdc7,Rbbp8,Anapc7,Nek6,Fbxw11,Mdm4,Prkca,Ywhaq,Clip1,Dyrk1a,Ccnd1,Mre11a,Phf8,Mcm6,Ppp2r5a,Cenpw,Psmd5,Pole2,Spo11,Rab2a,H2afz,Ywhag,Nek2,Cdk6,Nup88,Lmnb1,Lpin1,H3f3a,Rmi2,Blm,Pds5b,Hsp90ab1,Cenpf,Pold2,Ndel1,Rad21,Tubgcp4,Prkar2b R-MMU-74160 Gene Expression 0.999999961254555 -3.87454456151804e-08 1163 197 0.0990945674044266 1988 8688 226830,433586,68428,80707,71702,19981,69181,70088,18997,16009,14791,71713,69790,21834,216987,50911,13865,20602,12144,18667,66596,22084,75627,19883,20924,13871,19704,67486,208595,192119,51788,18718,22628,12177,13435,26399,223970,104625,66475,70122,20383,218210,21981,70640,12021,11737,67204,66441,97064,19944,66070,12447,15387,19921,66373,20393,108099,17127,19664,19946,22061,26416,67381,72068,26914,67678,100502825,15481,213895,641340,18753,107686,209456,17246,17684,18132,50783,20481,71805,52830,26440,17463,28077,13433,76130,26423,192657,264064,17248,228980,18750,227743,225998,18130,22630,267019,13982,56422,17535,78929,15511,214133,66998,235497,218333,73674,73699,67755,225182,229279,66642,67465,21679,22184,26992,53975,20090,26424,14782,68436,11545,74370,68592,66446,21815,19744,14109,66313,217337,67655,18129,24116,68135,11569,19069,67276,215193,15078,67895,22025,110532,76522,13716,57316,327987,319955,22631,64340,233833,15378,69305,63856,74747,68576,12192,73666,20813,67285,21676,67768,68183,228829,20181,17420,17191,237221,319177,106931,78651,69263,18607,218772,239528,20018,20620,94112,14815,56488,13197,14536,26443,22166,72949,50912,56417,270118,12393,77976,56040,101861,17164,68975,72587,15258,18128,21975,68981 Smyd2,Maml3,Steap3,Wwox,Cdc5l,Rpl37a,Dyrk2,Meaf6,Pou4f2,Igfbp3,Emg1,Cdc40,Med30,Thrb,Utp6,Exosc9,Nr2f1,Ncor2,Blm,Pgr,Gtf3a,Tsc2,Snapc1,Rora,Supt5,Ercc2,Upf1,Polr3g,Mterf1b,Dicer1,H2afz,Pip4k2a,Ywhag,Bnip3l,Dnmt3a,Map2k6,Rmi2,Cnot6,Rps23,Mllt3,Srsf3,Nup153,Ppp1r13b,Dcp2,Bard1,Anp32a,Eif2s2,Magohb,Wwtr1,Rpl29,Cwc15,Ccne1,Hnrnpk,Rpl19,Lsm5,Sgk1,Prkag2,Smad3,Rbpj,Rpl30,Trp63,Mapk14,Med4,Cnot2,H2afy,Lsm3,Rpl37rt,Hspa8,Bms1,Nrbf2,Prkcd,Snrpd2,Trp53bp2,Mdm2,Cited2,Notch4,Lsm4,Ski,Nup93,Pnrc2,Psma1,Psmd7,Med10,Dnmt1,Las1l,Nr5a1,Ell2,Cdk8,Mdm4,Taf4,Prkca,Mapkap1,Rorb,Ints6,Ywhaq,Rps15a,Esr1,Hbs1l,Mre11a,Polr3h,Hspa1b,Tet2,Psmd5,Leo1,Ice1,Wdr75,Ppp2r1b,Ddx47,Rbbp8,Hnrnpa3,Ctnnbl1,Sf3a1,Tead4,Zrsr2,Brd7,Ddx20,Rps29,Nr5a2,Gsr,Rpl34,Parp1,Rptor,Syf2,Exosc7,Tgif1,Rheb,Fau,Smurf2,Srp68,Ctdp1,Notch2,Nelfa,Eif3h,Aebp2,Nup88,Eri1,Utp25,H3f3a,Ppa1,Nr2c1,Adarb1,Lsm8,Ell,C1d,Med13,Ercc6,Ywhaz,Dhx38,Tnrc6a,Hnf4a,Dcps,Taf8,Ddit4,Lamtor5,Zfp36l1,Thoc3,Srp14,Cwc27,Tead1,N6amt1,Bcas2,Phf20,Rxra,Mnat1,Mbd2,Gemin8,Hist1h2ba,Kctd1,Lsm6,Rfc3,Pdpk1,Rarb,Ago2,Polr1d,Plk2,Med15,Nr3c1,Nxt1,Gadd45a,Nr6a1,Psma6,Txn1,Ccnt2,Exosc10,Adar,Maml2,Runx2,Nuak1,Rplp1,Ints4,Mapkapk2,Med27,Pan3,Hipk2,Notch1,Top3a,Snrpa1 R-MMU-372790 Signaling by GPCR 0.999999993429333 -6.57066704074447e-09 1331 227 0.114185110663984 1988 8688 12313,71111,13617,20779,18706,226849,30878,14773,50501,74191,80910,213649,240168,18673,269060,11852,24111,20111,78134,15234,319229,18708,54324,13605,16591,11554,18573,12323,14573,80901,227717,17967,80903,16451,75547,11551,15559,15557,230972,218397,140498,19065,258151,84112,23945,57254,13609,109648,83770,114715,13616,56349,320127,14811,104418,16185,54153,54199,13869,216749,26946,11548,20418,11820,238871,14360,18590,24001,14744,14607,74769,54611,14173,19084,67603,239766,11606,19414,11542,30938,14062,19227,17295,22045,432530,223435,11549,14683,18753,237880,622434,12223,18783,18217,13618,14652,18761,18322,17463,102098,26440,18795,13614,258330,258153,110197,18750,18798,108058,225192,66998,16443,217674,65086,14816,12374,224014,171530,18441,19735,50780,14172,18578,71704,73699,14675,208188,18583,14767,20742,54409,19228,104111,381413,26932,16453,20297,12801,12671,252837,18584,14708,109934,16438,12314,19088,17329,12981,14163,14083,16367,64214,18755,11515,277360,11535,13385,12062,18166,239283,12984,545156,12778,19220,110157,21844,16440,20608,11876,14063,18574,12326,18575,210044,19262,227333,380921,242425,14180,53972,240672,56183,224129,23984,57257,12919,54126,14745,70839,16439,12775,20662,140795,17200,258922,56066,15200,13610,18607,16800,83961,319239,14526,13649,51801,19204,19085,12424,12767,258426,11513,235584,230857,26443,16452,14701,20315,18430,18346,239530,69601,16183,217480,14182,14183,18619,19419 Calm1,Gpr39,Ednra,Src,Pik3ca,Ppp2r5a,Apln,Grk5,Prok2,P2ry13,Gpr84,Arhgef19,Rasgrp3,Phb,Dagla,Rhob,Uts2,Rps6ka1,Lpar4,Hgf,Sctr,Pik3r1,Arhgef5,Ect2,Kl,Adrb1,Pde1a,Camk2b,Gdnf,Cxcr6,Qrfp,Ncam1,Fgf16,Jak1,Akap13,Adra2a,Htr2b,Htr1f,Arhgef16,Rasa1,Rxfp2,Npy4r,Olfr1505,Sucnr1,Mgll,Tas2r119,S1pr1,Npy,Tas1r2,Spred1,Edn3,Net1,Dgki,Grin2a,Dgkz,Il2rb,Rasa4,Ccrl2,Erbb4,Nmur2,Trpc7,Adra1b,Shc3,App,Pde4d,Fyn,Pdgfa,Tiam2,Gpr65,Gip,Pik3cb,Pde3a,Fgf2,Prkar1a,Dusp6,Rtp1,Agt,Rasa3,Adora3,Fgd3,F2r,Pthlh,Met,Trhr,Adcy1,Trio,Adra1a,Gnas,Prkcd,1700071K01Rik,Arhgef26,Btc,Pla2g4a,Ntsr2,Ednrb,Glp1r,Prkcq,Olfr24,Psmd7,Arhgef18,Psma1,Plcb1,Edn1,Olfr1274-ps,Olfr412,Dgkg,Prkca,Plcb4,Camk2d,Hrh4,Psmd5,Itsn1,Gphb5,Lpar3,Grm1,Casr,Fgd4,Ucn2,P2ry1,Rgs2,Rgs3,Fgf18,Pde4b,Arhgef3,Ppp2r1b,Gna14,Ghsr,Pde7a,Nmur1,Sptbn1,Ramp2,Pth1r,Adcy3,Gpr176,Ppp2r5e,Jak3,Ccl20,Cnr1,Chrm3,Ackr4,Pde8a,Gng7,Abr,Itpr1,Calm2,Prkar2b,Cxcl9,Csf2,Fgd1,Ptk2,Irs1,Rgs18,Prkch,Adcy9,Prex1,Adm,Dlg4,Bdkrb2,Npy1r,Oxgr1,Csf2rb2,Kalrn,Ackr3,Ptgfr,Raf1,Tiam1,Itpr3,Sstr4,Artn,F2rl1,Pde1b,Camk4,Pde1c,Adcy2,Ptpra,Dgkd,Dgkh,Gabbr2,Fgf9,Ngef,Dusp5,Nmu,Adcy5,Pde10a,Vav3,Crhbp,Arhgef7,Lpar1,P2ry12,Itpr2,Ccr7,Sos1,P2ry14,Mc2r,Olfr267,Cxcl11,Hbegf,S1pr3,Pdpk1,Arhgef2,Nrg4,Npsr1,Gcg,Egfr,Ramp1,Ptafr,Prkar1b,Cck,Cxcr4,Olfr995,Adcy7,Dusp7,Ece1,Psma6,Jak2,Gng12,Cxcl12,Oxtr,Olfr47,Gpr20,Dab2ip,Il2,Dgkb,Fgfr1,Fgfr2,Penk,Rasgrp1 R-MMU-388396 GPCR downstream signaling 0.999999999853809 -1.46191139882294e-10 1065 159 0.0799798792756539 1988 8688 78134,269060,11852,24111,18708,13605,54324,319229,18573,11554,13617,50501,14773,74191,30878,213649,80910,18706,57254,23945,109648,13609,56349,13616,16451,75547,80901,227717,140498,19065,84112,258151,15557,11551,15559,230972,54611,14744,74769,14607,11606,239766,216749,11548,26946,320127,104418,16185,24001,238871,11820,13618,18217,18761,18322,14652,622434,13614,18795,258330,102098,19227,14062,11542,30938,14683,11549,18753,432530,22045,223435,18583,14675,208188,14767,71704,18578,104111,19228,381413,54409,18798,110197,258153,224014,12374,14816,65086,217674,19735,18441,50780,225192,16443,11535,18166,12062,11515,18755,64214,277360,12984,239283,18584,12671,109934,16453,12801,20297,16438,12981,14163,17329,57257,23984,224129,54126,56183,140795,17200,258922,12775,70839,16439,14745,20662,20608,14063,18574,545156,12778,21844,16440,19220,53972,227333,210044,242425,380921,16452,217480,16183,18619,20315,18346,239530,18430,319239,16800,14526,56066,13610,18607,11513,258426,12767,19204,51801,12424 Lpar4,Dagla,Rhob,Uts2,Pik3r1,Ect2,Arhgef5,Sctr,Pde1a,Adrb1,Ednra,Prok2,Grk5,P2ry13,Apln,Arhgef19,Gpr84,Pik3ca,Tas2r119,Mgll,Npy,S1pr1,Net1,Edn3,Jak1,Akap13,Cxcr6,Qrfp,Rxfp2,Npy4r,Sucnr1,Olfr1505,Htr1f,Adra2a,Htr2b,Arhgef16,Pde3a,Gpr65,Pik3cb,Gip,Agt,Rtp1,Nmur2,Adra1b,Trpc7,Dgki,Dgkz,Il2rb,Tiam2,Pde4d,App,Ednrb,Ntsr2,Prkcq,Olfr24,Glp1r,Arhgef26,Edn1,Plcb1,Olfr1274-ps,Arhgef18,Pthlh,F2r,Adora3,Fgd3,Gnas,Adra1a,Prkcd,Adcy1,Trhr,Trio,Pde7a,Gna14,Ghsr,Nmur1,Arhgef3,Pde4b,Adcy3,Pth1r,Gpr176,Ramp2,Plcb4,Dgkg,Olfr412,Fgd4,Casr,Grm1,Lpar3,Gphb5,Rgs2,P2ry1,Rgs3,Hrh4,Itsn1,Adm,Npy1r,Bdkrb2,Adcy9,Prkch,Rgs18,Prex1,Csf2rb2,Oxgr1,Pde8a,Chrm3,Abr,Jak3,Cnr1,Ccl20,Itpr1,Csf2,Fgd1,Cxcl9,Vav3,Pde10a,Adcy5,Arhgef7,Nmu,P2ry14,Mc2r,Olfr267,Ccr7,P2ry12,Itpr2,Lpar1,Sos1,Sstr4,F2rl1,Pde1b,Kalrn,Ackr3,Tiam1,Itpr3,Ptgfr,Ngef,Dgkd,Adcy2,Gabbr2,Dgkh,Jak2,Dgkb,Il2,Penk,Cxcl12,Olfr47,Gpr20,Oxtr,Npsr1,Arhgef2,Gcg,Cxcl11,S1pr3,Pdpk1,Adcy7,Olfr995,Cxcr4,Ptafr,Ramp1,Cck R-MMU-381753 Olfactory Signaling Pathway 0.999999999898561 -1.0143914974209e-10 535 8 0.00402414486921529 1988 8688 18346,258922,258426,258330,258151,239766,258153,18322 Olfr47,Olfr267,Olfr995,Olfr1274-ps,Olfr1505,Rtp1,Olfr412,Olfr24