<STREME version="5.4.1" release="Sat Aug 21 19:23:23 2021 -0700">
  <model>
    <command_line>streme --verbosity 1 --oc out_meme/streme_out -dna --p out_meme/seqs-centered --minw 6 --maxw 15 --order 2</command_line>
    <train_positives count="457" positions="45700" maxlen="100" file="out_meme/seqs-centered"/>
    <train_negatives count="457" positions="45700" from="shuffled"/>
    <test_positives count="50" positions="5000"/>
    <test_negatives count="50" positions="5000"/>
    <alphabet name="DNA" like="dna">
      <letter id="A" symbol="A" complement="T" name="Adenine" colour="CC0000"/>
      <letter id="C" symbol="C" complement="G" name="Cytosine" colour="0000CC"/>
      <letter id="G" symbol="G" complement="C" name="Guanine" colour="FFB300"/>
      <letter id="T" symbol="T" aliases="U" complement="A" name="Thymine" colour="008000"/>
      <letter id="N" symbol="N" aliases="X." equals="ACGT" name="Any base"/>
      <letter id="V" symbol="V" equals="ACG" name="Not T"/>
      <letter id="H" symbol="H" equals="ACT" name="Not G"/>
      <letter id="D" symbol="D" equals="AGT" name="Not C"/>
      <letter id="B" symbol="B" equals="CGT" name="Not A"/>
      <letter id="M" symbol="M" equals="AC" name="Amino"/>
      <letter id="R" symbol="R" equals="AG" name="Purine"/>
      <letter id="W" symbol="W" equals="AT" name="Weak"/>
      <letter id="S" symbol="S" equals="CG" name="Strong"/>
      <letter id="Y" symbol="Y" equals="CT" name="Pyrimidine"/>
      <letter id="K" symbol="K" equals="GT" name="Keto"/>
    </alphabet>
    <strands>both</strands>
    <sequence_db A="0.245" C="0.255" G="0.255" T="0.245"/>
    <background_frequencies source="--negatives--" order="2">
      <alphabet_array>
        <value letter_id="A">0.245</value>
        <value letter_id="C">0.255</value>
        <value letter_id="G">0.255</value>
        <value letter_id="T">0.245</value>
      </alphabet_array>
    </background_frequencies>
    <stop thresh_type="pvalue" thresh="0.05"/>
    <objfun>Differential Enrichment</objfun>
    <test>Fisher Exact Test</test>
    <minw>6</minw>
    <maxw>15</maxw>
    <kmer>3</kmer>
    <hofract>0.1</hofract>
    <neval>25</neval>
    <nref>4</nref>
    <niter>20</niter>
    <patience>3</patience>
    <seed>0</seed>
    <useer>no</useer>
    <minscore>0</minscore>
    <ignore_depth>5</ignore_depth>
    <nsubsets>1</nsubsets>
    <min_pal_ratio>0.85</min_pal_ratio>
    <max_pal_ed>5</max_pal_ed>
    <cand>no</cand>
    <experimental>no</experimental>
    <totallength>0</totallength>
    <align>center</align>
    <host>regmedhpc1</host>
  </model>
  <motifs>
    <motif id="1-GGTTACATAABAAVD" alt="STREME-1" width="15" initial_width="15" seed="GGTTACATAATAAGA" score_threshold="7.15645" train_pos_count="69" train_neg_count="11" train_log_pvalue="-11.8552" train_pvalue="1.4e-012" train_dtc="-1.0" train_bernoulli="-1" test_pos_count="8" test_neg_count="2" test_log_pvalue="-1.33891" test_pvalue="4.6e-002" test_log_evalue="-0.736851" test_evalue="1.8e-001" test_dtc="-1.0" test_bernoulli="-1" is_palindromic="no" elapsed_time="1.4" total_sites="69" site_distr=" 0 0 2 2 3 0 0 1 0 0 0 0 2 0 0 2 1 1 0 1 1 2 0 0 1 0 1 1 0 0 1 0 3 2 1 0 1 2 2 1 0 2 0 1 0 2 1 0 4 1 1 0 1 1 1 1 0 0 1 0 2 1 0 0 1 0 0 3 1 0 0 2 0 1 0 1 2 0 1 0 1 0 0 1 1" max_sites="5" site_hist=" 0 37 27 3 1 1">
      <pos A="0.20467" C="0.000833345" G="0.544522" T="0.249975"/>
      <pos A="0.046105" C="0.0914421" G="0.771043" T="0.0914094"/>
      <pos A="0.000800665" C="0.0234855" G="0.000833345" T="0.97488"/>
      <pos A="0.000800665" C="0.000833345" G="0.000833345" T="0.997533"/>
      <pos A="0.929576" C="0.000833345" G="0.0461377" T="0.0234529"/>
      <pos A="0.0234529" C="0.703087" G="0.000833345" T="0.272627"/>
      <pos A="0.771011" C="0.114094" G="0.114094" T="0.000800665"/>
      <pos A="0.046105" C="0.0234855" G="0.000833345" T="0.929576"/>
      <pos A="0.97488" C="0.000833345" G="0.0234855" T="0.000800665"/>
      <pos A="0.97488" C="0.000833345" G="0.000833345" T="0.0234529"/>
      <pos A="0.0687572" C="0.38592" G="0.227355" T="0.317967"/>
      <pos A="0.521837" C="0.114094" G="0.204703" T="0.159366"/>
      <pos A="0.431228" C="0.204703" G="0.182051" T="0.182018"/>
      <pos A="0.295279" C="0.27266" G="0.363304" T="0.0687572"/>
      <pos A="0.250011" C="0.159399" G="0.227355" T="0.363236"/>
    </motif>
    <motif id="2-TTCCAAG" alt="STREME-2" width="7" initial_width="6" seed="TTCCAAG" score_threshold="7.9453" train_pos_count="103" train_neg_count="41" train_log_pvalue="-7.9978" train_pvalue="1.0e-008" train_dtc="-1.0" train_bernoulli="-1" test_pos_count="12" test_neg_count="6" test_log_pvalue="-1.01716" test_pvalue="9.6e-002" test_log_evalue="-0.415103" test_evalue="3.8e-001" test_dtc="-1.0" test_bernoulli="-1" is_palindromic="no" elapsed_time="3.9" total_sites="103" site_distr=" 0 3 2 4 1 1 2 2 0 1 1 3 1 0 1 1 0 3 0 1 2 3 0 0 2 1 0 0 0 0 3 1 0 0 0 0 2 0 0 1 1 3 0 1 1 3 1 0 2 1 3 1 0 0 0 0 3 2 1 1 0 0 1 2 2 1 1 0 2 1 0 0 2 2 0 2 2 3 0 1 2 0 0 0 0 2 2 2 1 1 1 0 0" max_sites="2" site_hist=" 0 93 10">
      <pos A="0.0163967" C="0.0871294" G="0.000694402" T="0.895779"/>
      <pos A="0.0282863" C="0.019187" G="0.122454" T="0.830073"/>
      <pos A="0.0381122" C="0.873372" G="0.0878489" T="0.00066717"/>
      <pos A="0.0228329" C="0.878489" G="0.0195847" T="0.0790939"/>
      <pos A="0.783335" C="0.000694402" G="0.199125" T="0.0168461"/>
      <pos A="0.790746" C="0.0959356" G="0.000694402" T="0.112624"/>
      <pos A="0.0814299" C="0.0331264" G="0.798941" T="0.0865026"/>
    </motif>
    <motif id="3-CTTTGCT" alt="STREME-3" width="7" initial_width="6" seed="CTTTGCT" score_threshold="7.12589" train_pos_count="111" train_neg_count="51" train_log_pvalue="-6.90359" train_pvalue="1.2e-007" train_dtc="-1.0" train_bernoulli="-1" test_pos_count="12" test_neg_count="9" test_log_pvalue="-0.505738" test_pvalue="3.1e-001" test_log_evalue="0.0963224" test_evalue="1.2e+000" test_dtc="-1.0" test_bernoulli="-1" is_palindromic="no" elapsed_time="5.0" total_sites="111" site_distr=" 0 1 2 1 3 1 0 0 1 0 0 2 0 2 0 0 3 1 1 0 3 1 1 1 1 0 2 4 0 1 0 0 2 1 2 1 0 0 2 2 1 0 0 2 0 0 1 1 1 2 2 2 1 1 1 3 2 4 1 3 2 1 4 0 3 2 2 0 1 0 0 1 0 0 1 1 0 1 0 2 1 1 2 2 0 0 0 2 0 1 3 0 3" max_sites="2" site_hist=" 0 96 15">
      <pos A="0.0347229" C="0.840301" G="0.0329726" T="0.0920036"/>
      <pos A="0.0255517" C="0.0199897" G="0.158198" T="0.796261"/>
      <pos A="0.176272" C="0.000907924" G="0.000907924" T="0.821912"/>
      <pos A="0.000872319" C="0.000907924" G="0.326327" T="0.671893"/>
      <pos A="0.0122325" C="0.0658666" G="0.921029" T="0.000872319"/>
      <pos A="0.000872319" C="0.939644" G="0.058611" T="0.000872319"/>
      <pos A="0.075263" C="0.0795713" G="0.000907924" T="0.844258"/>
    </motif>
    <motif id="4-AAAGGGAAC" alt="STREME-4" width="9" initial_width="8" seed="AAAGGGAAC" score_threshold="8.63995" train_pos_count="53" train_neg_count="9" train_log_pvalue="-8.76558" train_pvalue="1.7e-009" train_dtc="-1.0" train_bernoulli="-1" test_pos_count="2" test_neg_count="3" test_log_pvalue="-0.0867634" test_pvalue="8.2e-001" test_log_evalue="0.515297" test_evalue="3.3e+000" test_dtc="-1.0" test_bernoulli="-1" is_palindromic="no" elapsed_time="2.6" total_sites="53" site_distr=" 0 1 0 3 1 0 0 2 0 0 0 1 0 1 2 0 0 0 0 0 0 0 2 0 0 0 1 0 2 1 0 0 0 1 0 0 1 0 1 0 0 0 2 0 1 0 1 0 2 1 0 1 0 1 1 0 1 0 0 0 0 1 1 4 1 0 1 1 0 0 1 0 0 0 0 0 2 0 1 0 0 0 0 2 1 1 1 0 1 0 0" max_sites="2" site_hist=" 0 52 1">
      <pos A="0.922256" C="0.0509336" G="0.0259268" T="0.000883891"/>
      <pos A="0.847196" C="0.0509731" G="0.0759404" T="0.0258907"/>
      <pos A="0.797182" C="0.0759404" G="0.0259268" T="0.100951"/>
      <pos A="0.0112495" C="0.0259268" G="0.886919" T="0.0759043"/>
      <pos A="0.0362563" C="0.0259268" G="0.836866" T="0.100951"/>
      <pos A="0.10099" C="0.125994" G="0.711753" T="0.0612631"/>
      <pos A="0.89713" C="0.0760591" G="0.0259268" T="0.000883891"/>
      <pos A="0.897249" C="0.0259268" G="0.000919969" T="0.0759043"/>
      <pos A="0.100951" C="0.822186" G="0.0259268" T="0.050937"/>
    </motif>
  </motifs>
  <reason_for_stopping>Stopped because 3 consecutive motifs exceeded the p-value threshold (0.05).</reason_for_stopping>
  <run_time cpu="5.10"/>
</STREME>
