Category ID Name Source p-value q-value Bonferroni q-value FDR B&H q-value FDR B&Y Hit Count in Query List Hit Count in Genome Hit in Query List GO: Biological Process GO:0009719 response to endogenous stimulus 1.515E-15 6.239E-12 6.239E-12 5.553E-11 46 1893 SFRP2,SFRP4,ANGPT2,COMP,INHBA,INHBB,GDF15,FOS,FOSB,DUSP6,GDF6,SOCS3,NR4A2,CP,LMO3,NR4A1,APOE,SSTR1,GDF10,CXCL1,CXCL2,PTGFR,CXCL3,PTGS2,CRHBP,AREG,STC1,FOSL1,KLF2,MMRN1,MSX1,BMP6,JUNB,TRIB3,EGR1,EGR2,EGR3,HES1,CLDN5,TNF,MME,HAS1,CCL21,HES5,IL6,ADAMTSL2 GO: Biological Process GO:0001568 blood vessel development 1.609E-14 6.627E-11 3.313E-11 2.949E-10 32 952 NPPC,ZC3H12A,SFRP2,ANGPT2,COMP,CXCL10,SOCS3,CLIC3,SOX17,SOX18,APOD,CHI3L1,NR4A1,APOE,PTGS2,FOSL1,KLF2,NRARP,MMRN1,LIF,JUNB,THBS4,EGR1,APOLD1,EGR2,EGR3,HES1,PROK1,CLDN5,TNF,IL6,PRRX2 GO: Biological Process GO:0072359 circulatory system development 2.805E-14 1.155E-10 3.851E-11 3.428E-10 39 1473 NPPC,ZC3H12A,SFRP2,ANGPT2,COMP,INHBA,CXCL10,DUSP6,SOCS3,CLIC3,SOX17,SOX18,SHOX2,NOX4,APOD,CHI3L1,NR4A1,APOE,RGS4,PTGS2,FOSL1,KLF2,NRARP,MMRN1,MSX1,LIF,JUNB,THBS4,EGR1,APOLD1,EGR2,EGR3,HES1,PROK1,CLDN5,TNF,SNAI1,IL6,PRRX2 GO: Biological Process GO:2000026 regulation of multicellular organismal development 4.826E-14 1.988E-10 4.351E-11 3.872E-10 43 1821 ZC3H12A,SFRP2,SFRP4,ANGPT2,COMP,INHBA,CXCL10,HLA-DQA2,FOS,DUSP6,GDF6,CLIC3,SOX17,ETV4,SHOX2,CHI3L1,CD83,SOX8,APOE,BHLHE40,RGS4,KLF2,NRARP,MSX1,LIF,BMP6,JUNB,THBS4,CSF3,APOLD1,EGR2,EGR3,FRZB,HES1,PROK1,CLDN5,TNF,MAFF,MME,CCL21,HES5,IL6,TPBG GO: Biological Process GO:0001944 vasculature development 5.281E-14 2.175E-10 4.351E-11 3.872E-10 32 994 NPPC,ZC3H12A,SFRP2,ANGPT2,COMP,CXCL10,SOCS3,CLIC3,SOX17,SOX18,APOD,CHI3L1,NR4A1,APOE,PTGS2,FOSL1,KLF2,NRARP,MMRN1,LIF,JUNB,THBS4,EGR1,APOLD1,EGR2,EGR3,HES1,PROK1,CLDN5,TNF,IL6,PRRX2 GO: Biological Process GO:0051241 negative regulation of multicellular organismal process 2.565E-13 1.056E-9 1.761E-10 1.567E-9 38 1499 ZC3H12A,SFRP2,ANGPT2,INHBA,INHBB,CXCL10,HLA-DQA2,GDF15,DUSP5,ETV4,APOC1,TNFRSF10D,APOD,CD83,SOX8,APOE,F2R,F2RL1,GDF10,RGS4,PTGS2,CRHBP,TNFRSF4,STC1,KLF2,NRARP,LIF,THBS4,FRZB,PLAT,HES1,PLAUR,CLDN5,TNF,PRG4,HES5,IL6,CNR1 GO: Biological Process GO:0035295 tube development 3.690E-13 1.520E-9 2.171E-10 1.933E-9 37 1438 NPPC,ZC3H12A,SFRP2,ANGPT2,COMP,INHBB,CXCL10,GDF6,CLIC3,SOX17,ETV4,SOX18,SHOX2,APOD,CHI3L1,NR4A1,SOX8,APOE,PTGS2,AREG,KLF2,NRARP,MMRN1,LIF,JUNB,THBS4,APOLD1,EGR3,HES1,PROK1,CLDN5,TNF,MME,HES5,IL6,ADAMTSL2,PRRX2 GO: Biological Process GO:0035239 tube morphogenesis 4.530E-13 1.866E-9 2.332E-10 2.076E-9 33 1147 NPPC,ZC3H12A,SFRP2,ANGPT2,COMP,CXCL10,CLIC3,SOX17,ETV4,SOX18,SHOX2,APOD,CHI3L1,NR4A1,SOX8,APOE,PTGS2,AREG,KLF2,NRARP,MMRN1,LIF,JUNB,THBS4,APOLD1,EGR3,HES1,PROK1,CLDN5,TNF,HES5,IL6,PRRX2 GO: Biological Process GO:0006954 inflammatory response 6.603E-13 2.720E-9 3.022E-10 2.690E-9 32 1091 ZC3H12A,CXCL10,NT5E,FOS,SOCS3,NOX4,CP,APOD,CHI3L1,NR4A1,APOE,F2R,F2RL1,CXCL1,CXCL2,PTGFR,CXCL3,PTGIR,PTGS2,BDKRB2,CRHBP,TNFRSF4,FOSL1,BMP6,IER3,TNF,CCL14,CCL21,HBA1,DNASE1L3,IL6,CNR1 GO: Biological Process GO:0045595 regulation of cell differentiation 8.660E-13 3.567E-9 3.567E-10 3.175E-9 43 1981 NPPC,ZC3H12A,SFRP2,SFRP4,INHBA,CXCL10,HLA-DQA2,FOS,GDF6,SOCS3,SOX17,ETV4,SHOX2,LMO3,CD83,SOX8,APOE,GDF10,BHLHE40,RGS4,PTGS2,AREG,NRARP,MSX1,LIF,BMP6,JUNB,IGFBP3,CSF3,TRIB3,APOLD1,EGR2,EGR3,FRZB,HES1,CLDN5,TNF,MAFF,MME,SNAI1,CCL21,HES5,IL6 GO: Biological Process GO:0048514 blood vessel morphogenesis 1.145E-12 4.714E-9 4.286E-10 3.815E-9 28 840 NPPC,ZC3H12A,SFRP2,ANGPT2,COMP,CXCL10,CLIC3,SOX17,SOX18,APOD,CHI3L1,NR4A1,APOE,PTGS2,KLF2,NRARP,MMRN1,LIF,JUNB,THBS4,APOLD1,EGR3,HES1,PROK1,CLDN5,TNF,IL6,PRRX2 GO: Biological Process GO:0045597 positive regulation of cell differentiation 2.236E-12 9.209E-9 7.674E-10 6.830E-9 32 1142 NPPC,ZC3H12A,SFRP2,SFRP4,INHBA,HLA-DQA2,FOS,GDF6,SOCS3,SOX17,ETV4,SHOX2,LMO3,CD83,SOX8,APOE,GDF10,PTGS2,LIF,BMP6,JUNB,IGFBP3,CSF3,EGR2,EGR3,FRZB,HES1,CLDN5,TNF,MME,SNAI1,IL6 GO: Biological Process GO:0009725 response to hormone 4.749E-12 1.956E-8 1.505E-9 1.339E-8 32 1175 SFRP4,INHBA,INHBB,GDF15,FOS,FOSB,SOCS3,NR4A2,CP,LMO3,NR4A1,SSTR1,CXCL1,CXCL2,PTGFR,CXCL3,PTGS2,CRHBP,AREG,STC1,FOSL1,KLF2,BMP6,JUNB,TRIB3,EGR1,EGR2,HES1,TNF,MME,CCL21,IL6 GO: Biological Process GO:0023057 negative regulation of signaling 6.047E-12 2.491E-8 1.748E-9 1.556E-8 40 1833 ZC3H12A,SFRP2,SFRP4,INHBA,INHBB,GDF15,DUSP2,DUSP5,DUSP6,SOCS3,NR4A2,SOX17,LMO3,APOD,APOE,F2RL1,PTGIR,RGS1,RGS4,PTGS2,BDKRB2,CRHBP,TNFRSF4,NRARP,MMRN1,LIF,IGFBP3,TRIB3,EGR1,IER3,FRZB,PLAUR,TNF,SNAI1,PLK3,IL6,DKK2,ADAMTSL2,TPBG,SHISA3 GO: Biological Process GO:0010648 negative regulation of cell communication 6.365E-12 2.622E-8 1.748E-9 1.556E-8 40 1836 ZC3H12A,SFRP2,SFRP4,INHBA,INHBB,GDF15,DUSP2,DUSP5,DUSP6,SOCS3,NR4A2,SOX17,LMO3,APOD,APOE,F2RL1,PTGIR,RGS1,RGS4,PTGS2,BDKRB2,CRHBP,TNFRSF4,NRARP,MMRN1,LIF,IGFBP3,TRIB3,EGR1,IER3,FRZB,PLAUR,TNF,SNAI1,PLK3,IL6,DKK2,ADAMTSL2,TPBG,SHISA3 GO: Biological Process GO:0009968 negative regulation of signal transduction 9.243E-12 3.807E-8 2.380E-9 2.118E-8 38 1686 ZC3H12A,SFRP2,SFRP4,GDF15,DUSP2,DUSP5,DUSP6,SOCS3,NR4A2,SOX17,LMO3,APOD,APOE,F2RL1,PTGIR,RGS1,RGS4,PTGS2,BDKRB2,CRHBP,TNFRSF4,NRARP,MMRN1,LIF,IGFBP3,TRIB3,EGR1,IER3,FRZB,PLAUR,TNF,SNAI1,PLK3,IL6,DKK2,ADAMTSL2,TPBG,SHISA3 GO: Biological Process GO:0051094 positive regulation of developmental process 1.065E-11 4.387E-8 2.581E-9 2.297E-8 38 1694 NPPC,ZC3H12A,SFRP2,SFRP4,ANGPT2,INHBA,HLA-DQA2,GDF15,FOS,GDF6,SOCS3,CLIC3,SOX17,ETV4,SHOX2,LMO3,CHI3L1,CD83,SOX8,APOE,GDF10,PTGS2,MSX1,LIF,BMP6,JUNB,IGFBP3,CSF3,EGR2,EGR3,FRZB,HES1,CLDN5,TNF,MME,SNAI1,IL6,TPBG GO: Biological Process GO:0043067 regulation of programmed cell death 9.873E-11 4.067E-7 2.259E-8 2.011E-7 39 1916 NPPC,ZC3H12A,SFRP2,SFRP4,COMP,INHBA,INHBB,CXCL10,DUSP6,SOCS3,NR4A2,NOX4,TNFRSF10D,NR4A1,SOX8,APOE,F2R,F2RL1,CXCL2,PTGFR,PTGS2,BDKRB2,SLC2A3,TNFRSF4,FOSL1,MSX1,IGFBP3,EGR1,IER3,EGR3,FRZB,TREM1,PLAUR,TNF,SNAI1,CCL21,PLK3,IL6,CNR1 GO: Biological Process GO:0045444 fat cell differentiation 1.616E-10 6.657E-7 3.504E-8 3.119E-7 16 301 ZC3H12A,SFRP2,INHBB,GDF6,NR4A2,LMO3,NR4A1,SOX8,GDF10,PTGS2,TRIB3,EGR2,FRZB,HES1,TNF,IL6 GO: Biological Process GO:0048646 anatomical structure formation involved in morphogenesis 2.024E-10 8.339E-7 4.169E-8 3.711E-7 34 1524 NPPC,ZC3H12A,SFRP2,ANGPT2,INHBA,CXCL10,GDF15,DUSP2,DUSP5,CLIC3,SOX17,SOX18,APOD,CHI3L1,NR4A1,SOX8,PTGS2,KLF2,NRARP,MMRN1,MSX1,LIF,JUNB,THBS4,APOLD1,EGR2,EGR3,HES1,PROK1,CLDN5,TNF,SNAI1,HES5,IL6 GO: Biological Process GO:0016477 cell migration 2.817E-10 1.160E-6 5.449E-8 4.850E-7 38 1894 ZC3H12A,SFRP2,ANGPT2,CXCL10,GDF15,GDF6,CH25H,NR4A2,SOX17,SOX18,NOX4,APOD,NR4A1,SOX8,APOE,F2R,F2RL1,CXCL1,CXCL2,CXCL3,PTGS2,STC1,MMRN1,THBS4,IGFBP3,EGR1,EGR3,TREM1,PLAT,HES1,CLDN5,TNF,CCL14,SNAI1,HAS1,CCL21,IL6,TPBG GO: Biological Process GO:0007167 enzyme-linked receptor protein signaling pathway 2.910E-10 1.199E-6 5.449E-8 4.850E-7 30 1218 NPPC,SFRP2,SFRP4,ANGPT2,COMP,INHBA,INHBB,GDF15,FOS,GDF6,SOCS3,APOD,GDF10,PTGIR,BDKRB2,AREG,MMRN1,MSX1,LIF,BMP6,IGFBP3,TRIB3,EGR1,PLAT,HES1,PLAUR,CLDN5,TNF,HES5,ADAMTSL2 GO: Biological Process GO:0071495 cellular response to endogenous stimulus 3.220E-10 1.326E-6 5.767E-8 5.133E-7 34 1551 SFRP2,SFRP4,ANGPT2,COMP,INHBA,INHBB,GDF15,FOS,FOSB,GDF6,SOCS3,NR4A2,LMO3,NR4A1,SSTR1,GDF10,PTGFR,CRHBP,STC1,KLF2,MMRN1,MSX1,BMP6,TRIB3,EGR1,EGR3,HES1,CLDN5,TNF,HAS1,CCL21,HES5,IL6,ADAMTSL2 GO: Biological Process GO:0033993 response to lipid 3.404E-10 1.402E-6 5.842E-8 5.199E-7 30 1226 ZC3H12A,INHBA,INHBB,CXCL10,FOS,FOSB,LMO3,NR4A1,SSTR1,F2R,CXCL1,CXCL2,PTGFR,CXCL3,PTGIR,PTGS2,CRHBP,AREG,STC1,FOSL1,BMP6,JUNB,CSF3,SLPI,HES1,TNF,CCL21,GRAMD1C,IL6,CNR1 GO: Biological Process GO:0040011 locomotion 4.011E-10 1.652E-6 6.608E-8 5.882E-7 34 1564 NPPC,ZC3H12A,SFRP2,ANGPT2,CXCL10,GDF15,CH25H,NOX4,APOD,NR4A1,APOE,F2R,F2RL1,CXCL1,CXCL2,CXCL3,PTGS2,STC1,FOSL1,MMRN1,THBS4,IGFBP3,EGR1,EGR3,TREM1,PLAUR,CLDN5,TNF,CCL14,SNAI1,HAS1,CCL21,IL6,TPBG GO: Biological Process GO:0001525 angiogenesis 4.794E-10 1.975E-6 7.594E-8 6.760E-7 23 731 NPPC,ZC3H12A,SFRP2,ANGPT2,CXCL10,CLIC3,SOX17,SOX18,APOD,CHI3L1,NR4A1,PTGS2,KLF2,NRARP,MMRN1,LIF,THBS4,APOLD1,EGR3,PROK1,CLDN5,TNF,IL6 GO: Biological Process GO:0042981 regulation of apoptotic process 6.140E-10 2.529E-6 9.367E-8 8.337E-7 37 1855 NPPC,ZC3H12A,SFRP2,SFRP4,COMP,INHBA,INHBB,CXCL10,DUSP6,SOCS3,NR4A2,NOX4,TNFRSF10D,NR4A1,SOX8,APOE,F2R,PTGFR,PTGS2,BDKRB2,SLC2A3,TNFRSF4,FOSL1,MSX1,IGFBP3,EGR1,IER3,EGR3,FRZB,TREM1,PLAUR,TNF,SNAI1,CCL21,PLK3,IL6,CNR1 GO: Biological Process GO:0043408 regulation of MAPK cascade 1.115E-9 4.593E-6 1.640E-7 1.460E-6 24 833 ZC3H12A,SFRP2,SFRP4,INHBA,GDF15,DUSP2,DUSP5,DUSP6,GDF6,NOX4,LMO3,CHI3L1,APOE,F2R,F2RL1,LIF,IGFBP3,TRIB3,PROK1,TNF,CCL21,IL6,EDA2R,TPBG GO: Biological Process GO:1901698 response to nitrogen compound 1.426E-9 5.873E-6 2.025E-7 1.803E-6 31 1385 NPPC,INHBA,INHBB,NT5E,GDF15,FOS,FOSB,SOCS3,NR4A2,SOX17,CP,NR4A1,APOE,GDF10,CXCL1,CXCL2,CXCL3,RGS4,PTGS2,CRHBP,AREG,STC1,FOSL1,KLF2,TRIB3,EGR1,EGR2,HES1,TNF,IL6,CNR1 GO: Biological Process GO:0031960 response to corticosteroid 2.871E-9 1.183E-5 3.942E-7 3.509E-6 13 222 INHBA,FOS,FOSB,CXCL1,CXCL2,CXCL3,PTGS2,AREG,STC1,FOSL1,BMP6,TNF,IL6 GO: Biological Process GO:0060429 epithelium development 3.078E-9 1.268E-5 4.090E-7 3.641E-6 32 1516 KRT7,NPPC,SFRP2,SFRP4,INHBA,CXCL10,GDF6,SOCS3,SOX17,ETV4,SOX18,SOX8,F2RL1,PTGS2,AREG,STC1,KLF2,NRARP,MSX1,LIF,BMP6,APOLD1,FRZB,HES1,PLAUR,CLDN5,TNF,MAFF,SNAI1,HES5,IL6,ADAMTSL2 GO: Biological Process GO:0034097 response to cytokine 3.525E-9 1.452E-5 4.478E-7 3.986E-6 28 1190 ZC3H12A,INHBA,INHBB,CXCL10,FOS,SOCS3,CH25H,SOX17,CHI3L1,SSTR1,F2RL1,CXCL1,CXCL2,CXCL3,PTGS2,CRHBP,TNFRSF4,FOSL1,KLF2,CSF3,EGR1,HES1,TNF,CCL14,MME,CCL21,IL6,EDA2R GO: Biological Process GO:0000165 MAPK cascade 3.672E-9 1.512E-5 4.478E-7 3.986E-6 25 959 ZC3H12A,SFRP2,SFRP4,INHBA,GDF15,DUSP2,DUSP5,DUSP6,GDF6,NOX4,LMO3,CHI3L1,APOE,F2R,F2RL1,LIF,IGFBP3,TRIB3,CDC42EP5,PROK1,TNF,CCL21,IL6,EDA2R,TPBG GO: Biological Process GO:0008284 positive regulation of cell population proliferation 3.726E-9 1.535E-5 4.478E-7 3.986E-6 28 1193 SFRP2,COMP,CXCL10,SHOX2,NR4A1,SOX8,F2R,CXCL2,PTGFR,PTGS2,AREG,TNFRSF4,FOSL1,NRARP,LIF,BMP6,THBS4,CSF3,EGR1,EGR3,HES1,PROK1,CLDN5,TNF,CCL14,HES5,IL6,PRRX2 GO: Biological Process GO:0007267 cell-cell signaling 3.808E-9 1.569E-5 4.478E-7 3.986E-6 33 1617 NPPC,SFRP2,INHBA,INHBB,CXCL10,GDF15,PCDHB2,NR4A1,APOE,F2R,F2RL1,F2RL2,PTGIR,RGS4,PTGS2,CRHBP,AREG,LIF,BMP6,IGFBP3,EGR1,EGR2,EGR3,FGFBP2,PLAT,HES1,TNF,MME,GSG1L,CCL21,IL6,CNR1,TPBG GO: Biological Process GO:0097305 response to alcohol 3.914E-9 1.612E-5 4.478E-7 3.986E-6 16 375 NPPC,INHBA,INHBB,FOS,FOSB,PTGFR,RGS4,CRHBP,FOSL1,KLF2,CSF3,CLDN5,TNF,CCL21,GRAMD1C,CNR1 GO: Biological Process GO:0051384 response to glucocorticoid 5.126E-9 2.112E-5 5.558E-7 4.947E-6 12 190 FOS,FOSB,CXCL1,CXCL2,CXCL3,PTGS2,AREG,STC1,FOSL1,BMP6,TNF,IL6 GO: Biological Process GO:0003013 circulatory system process 5.145E-9 2.119E-5 5.558E-7 4.947E-6 22 757 NPPC,ZC3H12A,COMP,CXCL10,DUSP5,SHOX2,NOX4,APOE,F2R,F2RL1,RGS4,PTGS2,BDKRB2,SLC2A3,STC1,KLF2,BMP6,IER3,CLDN5,TNF,MME,CNR1 GO: Biological Process GO:1901652 response to peptide 5.362E-9 2.209E-5 5.558E-7 4.947E-6 28 1213 ZC3H12A,INHBA,INHBB,CXCL10,FOS,SOCS3,CH25H,SOX17,CHI3L1,SSTR1,F2RL1,CXCL1,CXCL2,CXCL3,PTGS2,CRHBP,TNFRSF4,FOSL1,KLF2,CSF3,EGR1,HES1,TNF,CCL14,MME,CCL21,IL6,EDA2R GO: Biological Process GO:0043068 positive regulation of programmed cell death 5.397E-9 2.223E-5 5.558E-7 4.947E-6 22 759 ZC3H12A,SFRP2,SFRP4,INHBA,INHBB,DUSP6,NOX4,TNFRSF10D,NR4A1,F2R,F2RL1,CXCL2,PTGS2,FOSL1,MSX1,IGFBP3,EGR1,FRZB,TREM1,TNF,IL6,CNR1 GO: Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II 5.654E-9 2.329E-5 5.680E-7 5.055E-6 30 1382 ZC3H12A,SFRP2,INHBA,CXCL10,FOS,FOSB,NR4A2,SOX17,ETV4,SOX18,LMO3,NR4A1,SOX8,F2RL1,FOSL1,KLF2,MSX1,LIF,BMP6,JUNB,CSF3,EGR1,EGR2,EGR3,HES1,TNF,MAFF,HES5,IL6,PRRX2 GO: Biological Process GO:0071345 cellular response to cytokine stimulus 5.910E-9 2.434E-5 5.796E-7 5.158E-6 26 1059 ZC3H12A,INHBA,INHBB,CXCL10,FOS,SOCS3,SOX17,CHI3L1,SSTR1,F2RL1,CXCL1,CXCL2,CXCL3,CRHBP,TNFRSF4,FOSL1,KLF2,CSF3,EGR1,HES1,TNF,CCL14,MME,CCL21,IL6,EDA2R GO: Biological Process GO:0051216 cartilage development 1.317E-8 5.425E-5 1.262E-6 1.123E-5 13 252 NPPC,SFRP2,COMP,GDF6,SHOX2,CHI3L1,STC1,MSX1,BMP6,FRZB,SNAI1,HES5,PRRX2 GO: Biological Process GO:0070555 response to interleukin-1 1.682E-8 6.929E-5 1.575E-6 1.402E-5 10 131 ZC3H12A,INHBB,CHI3L1,CXCL1,CXCL2,CXCL3,KLF2,EGR1,HES1,IL6 GO: Biological Process GO:0061448 connective tissue development 1.761E-8 7.254E-5 1.590E-6 1.416E-5 15 361 NPPC,SFRP2,COMP,GDF6,SHOX2,CHI3L1,SOX8,STC1,MSX1,BMP6,EGR1,FRZB,SNAI1,HES5,PRRX2 GO: Biological Process GO:0051051 negative regulation of transport 1.776E-8 7.316E-5 1.590E-6 1.416E-5 19 603 SFRP4,INHBA,INHBB,APOC1,APOD,APOE,F2R,F2RL1,RGS4,PTGS2,CRHBP,STC1,LIF,IGFBP3,SLN,HES1,TNF,IL6,CNR1 GO: Biological Process GO:0008285 negative regulation of cell population proliferation 1.873E-8 7.714E-5 1.641E-6 1.461E-5 24 963 NPPC,SFRP2,SFRP4,INHBA,HLA-DQA2,ETV4,NOX4,APOD,APOE,SSTR1,F2R,CXCL1,PTGIR,PTGS2,BDKRB2,FOSL1,MSX1,LIF,IGFBP3,FRZB,HES1,TNF,IL6,TPBG GO: Biological Process GO:0008015 blood circulation 1.913E-8 7.881E-5 1.642E-6 1.461E-5 20 673 NPPC,ZC3H12A,COMP,CXCL10,DUSP5,SHOX2,APOE,F2R,F2RL1,RGS4,PTGS2,BDKRB2,STC1,KLF2,BMP6,IER3,CLDN5,TNF,MME,CNR1 GO: Biological Process GO:0045893 positive regulation of DNA-templated transcription 2.094E-8 8.625E-5 1.738E-6 1.547E-5 34 1826 ZC3H12A,SFRP2,INHBA,CXCL10,FOS,FOSB,GDF6,NR4A2,SOX17,ETV4,SOX18,LMO3,NR4A1,SOX8,APOE,F2R,F2RL1,FOSL1,KLF2,MSX1,LIF,BMP6,JUNB,CSF3,EGR1,EGR2,EGR3,HES1,TNF,MAFF,SNAI1,HES5,IL6,PRRX2 GO: Biological Process GO:0071347 cellular response to interleukin-1 2.126E-8 8.756E-5 1.738E-6 1.547E-5 9 100 ZC3H12A,INHBB,CXCL1,CXCL2,CXCL3,KLF2,EGR1,HES1,IL6 GO: Biological Process GO:1902680 positive regulation of RNA biosynthetic process 2.152E-8 8.862E-5 1.738E-6 1.547E-5 34 1828 ZC3H12A,SFRP2,INHBA,CXCL10,FOS,FOSB,GDF6,NR4A2,SOX17,ETV4,SOX18,LMO3,NR4A1,SOX8,APOE,F2R,F2RL1,FOSL1,KLF2,MSX1,LIF,BMP6,JUNB,CSF3,EGR1,EGR2,EGR3,HES1,TNF,MAFF,SNAI1,HES5,IL6,PRRX2 GO: Biological Process GO:0044057 regulation of system process 2.379E-8 9.800E-5 1.885E-6 1.677E-5 21 752 NPPC,ZC3H12A,INHBA,INHBB,DUSP5,SHOX2,NR4A1,APOE,F2R,F2RL1,RGS4,PTGS2,BDKRB2,CRHBP,STC1,LIF,BMP6,EGR2,SLN,TNF,IL6 GO: Biological Process GO:0030856 regulation of epithelial cell differentiation 2.780E-8 1.145E-4 2.161E-6 1.923E-5 12 221 SFRP4,ETV4,MSX1,LIF,BMP6,APOLD1,FRZB,HES1,CLDN5,TNF,MAFF,HES5 GO: Biological Process GO:0030855 epithelial cell differentiation 2.930E-8 1.207E-4 2.235E-6 1.989E-5 23 909 KRT7,NPPC,SFRP4,INHBA,SOX17,ETV4,SOX18,SOX8,F2RL1,PTGS2,STC1,KLF2,MSX1,LIF,BMP6,APOLD1,FRZB,HES1,PLAUR,CLDN5,TNF,MAFF,HES5 GO: Biological Process GO:0001975 response to amphetamine 3.236E-8 1.333E-4 2.423E-6 2.157E-5 7 49 FOSB,NR4A2,NR4A1,CXCL1,CXCL2,CXCL3,RGS4 GO: Biological Process GO:0032496 response to lipopolysaccharide 3.372E-8 1.389E-4 2.480E-6 2.208E-5 17 498 ZC3H12A,CXCL10,FOS,NR4A1,F2R,CXCL1,CXCL2,PTGFR,CXCL3,PTGIR,PTGS2,BMP6,CSF3,SLPI,TNF,IL6,CNR1 GO: Biological Process GO:0009967 positive regulation of signal transduction 4.234E-8 1.744E-4 3.060E-6 2.723E-5 34 1879 NPPC,ZC3H12A,SFRP2,SFRP4,INHBA,INHBB,GDF15,GDF6,SHOX2,NOX4,LMO3,CHI3L1,APOE,F2R,F2RL1,RGS4,KLF2,NRARP,MSX1,LIF,BMP6,IGFBP3,CSF3,HES1,PROK1,PLAUR,TNF,CCL21,HES5,IL6,EDA2R,DKK2,TPBG,PRRX2 GO: Biological Process GO:0050730 regulation of peptidyl-tyrosine phosphorylation 4.752E-8 1.957E-4 3.375E-6 3.004E-5 12 232 SFRP2,SOCS3,NOX4,AREG,LIF,BMP6,THBS4,CSF3,HES1,TNF,HES5,IL6 GO: Biological Process GO:0141091 transforming growth factor beta receptor superfamily signaling pathway 6.224E-8 2.564E-4 4.345E-6 3.868E-5 16 457 SFRP2,SFRP4,COMP,INHBA,INHBB,GDF15,FOS,GDF6,GDF10,MSX1,BMP6,EGR1,HES1,CLDN5,HES5,ADAMTSL2 GO: Biological Process GO:0006935 chemotaxis 6.653E-8 2.740E-4 4.567E-6 4.065E-5 17 522 ANGPT2,CXCL10,CH25H,NR4A1,F2RL1,CXCL1,CXCL2,CXCL3,FOSL1,THBS4,EGR3,TREM1,PLAUR,CCL14,CCL21,IL6,TPBG GO: Biological Process GO:0042330 taxis 7.029E-8 2.895E-4 4.746E-6 4.224E-5 17 524 ANGPT2,CXCL10,CH25H,NR4A1,F2RL1,CXCL1,CXCL2,CXCL3,FOSL1,THBS4,EGR3,TREM1,PLAUR,CCL14,CCL21,IL6,TPBG GO: Biological Process GO:0002237 response to molecule of bacterial origin 7.424E-8 3.058E-4 4.932E-6 4.390E-5 17 526 ZC3H12A,CXCL10,FOS,NR4A1,F2R,CXCL1,CXCL2,PTGFR,CXCL3,PTGIR,PTGS2,BMP6,CSF3,SLPI,TNF,IL6,CNR1 GO: Biological Process GO:0071396 cellular response to lipid 8.060E-8 3.320E-4 5.270E-6 4.691E-5 21 808 ZC3H12A,INHBA,INHBB,CXCL10,FOS,LMO3,SSTR1,CXCL1,CXCL2,PTGFR,CXCL3,PTGS2,CRHBP,STC1,BMP6,CSF3,HES1,TNF,CCL21,GRAMD1C,IL6 GO: Biological Process GO:0043065 positive regulation of apoptotic process 8.482E-8 3.494E-4 5.459E-6 4.859E-5 20 737 ZC3H12A,SFRP2,SFRP4,INHBA,INHBB,DUSP6,NOX4,TNFRSF10D,NR4A1,F2R,PTGS2,FOSL1,MSX1,IGFBP3,EGR1,FRZB,TREM1,TNF,IL6,CNR1 GO: Biological Process GO:0001775 cell activation 1.010E-7 4.159E-4 6.399E-6 5.696E-5 28 1392 NPPC,ZC3H12A,COMP,INHBA,CXCL10,HLA-DQA2,HLA-DQB2,SOCS3,CD83,NR4A1,APOE,F2R,F2RL1,F2RL2,TNFRSF4,NRARP,MMRN1,JUNB,EGR1,EGR3,PDIA2,PLAT,HES1,TNF,CCL21,DNASE1L3,IL6,CNR1 GO: Biological Process GO:1901701 cellular response to oxygen-containing compound 1.172E-7 4.826E-4 7.312E-6 6.508E-5 30 1582 NPPC,ZC3H12A,INHBA,INHBB,CXCL10,GDF15,FOS,SOCS3,NR4A2,NOX4,NR4A1,SSTR1,CXCL1,CXCL2,PTGFR,CXCL3,RGS4,PTGS2,CRHBP,STC1,KLF2,BMP6,CSF3,TRIB3,EGR1,HES1,TNF,CCL21,GRAMD1C,IL6 GO: Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 1.343E-7 5.531E-4 8.256E-6 7.348E-5 10 163 NOX4,AREG,LIF,BMP6,THBS4,CSF3,HES1,TNF,HES5,IL6 GO: Biological Process GO:0060326 cell chemotaxis 1.499E-7 6.175E-4 9.081E-6 8.083E-5 14 366 CXCL10,CH25H,NR4A1,F2RL1,CXCL1,CXCL2,CXCL3,THBS4,EGR3,TREM1,CCL14,CCL21,IL6,TPBG GO: Biological Process GO:0048729 tissue morphogenesis 1.717E-7 7.071E-4 1.005E-5 8.947E-5 20 770 SFRP2,INHBA,CXCL10,SOCS3,SOX17,ETV4,SOX18,SHOX2,SOX8,AREG,STC1,NRARP,MSX1,LIF,FRZB,HES1,TNF,SNAI1,HES5,IL6 GO: Biological Process GO:0044060 regulation of endocrine process 1.725E-7 7.104E-4 1.005E-5 8.947E-5 7 62 INHBA,INHBB,F2R,F2RL1,CRHBP,LIF,BMP6 GO: Biological Process GO:0048545 response to steroid hormone 1.733E-7 7.137E-4 1.005E-5 8.947E-5 15 430 INHBA,FOS,FOSB,LMO3,CXCL1,CXCL2,CXCL3,PTGS2,AREG,STC1,FOSL1,BMP6,JUNB,TNF,IL6 GO: Biological Process GO:0060284 regulation of cell development 1.897E-7 7.813E-4 1.085E-5 9.658E-5 24 1090 NPPC,ZC3H12A,INHBA,HLA-DQA2,FOS,SHOX2,CD83,SOX8,APOE,BHLHE40,NRARP,LIF,JUNB,CSF3,EGR2,EGR3,FRZB,HES1,CLDN5,TNF,MME,CCL21,HES5,IL6 GO: Biological Process GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway 1.948E-7 8.026E-4 1.099E-5 9.785E-5 16 497 SFRP2,SFRP4,COMP,INHBA,INHBB,GDF15,FOS,GDF6,GDF10,MSX1,BMP6,EGR1,HES1,CLDN5,HES5,ADAMTSL2 GO: Biological Process GO:0019220 regulation of phosphate metabolic process 2.346E-7 9.664E-4 1.306E-5 1.162E-4 25 1187 ZC3H12A,SFRP2,INHBA,DUSP6,SPATA18,SOCS3,NOX4,APOC1,CHI3L1,APOE,BDKRB2,AREG,TNFRSF4,LIF,BMP6,THBS4,IGFBP3,CSF3,TRIB3,IER3,HES1,PLAUR,TNF,HES5,IL6 GO: Biological Process GO:0051174 regulation of phosphorus metabolic process 2.422E-7 9.975E-4 1.330E-5 1.184E-4 25 1189 ZC3H12A,SFRP2,INHBA,DUSP6,SPATA18,SOCS3,NOX4,APOC1,CHI3L1,APOE,BDKRB2,AREG,TNFRSF4,LIF,BMP6,THBS4,IGFBP3,CSF3,TRIB3,IER3,HES1,PLAUR,TNF,HES5,IL6 GO: Biological Process GO:0043410 positive regulation of MAPK cascade 2.693E-7 1.109E-3 1.459E-5 1.299E-4 17 576 ZC3H12A,INHBA,GDF15,GDF6,NOX4,CHI3L1,APOE,F2R,F2RL1,LIF,IGFBP3,PROK1,TNF,CCL21,IL6,EDA2R,TPBG GO: Biological Process GO:0062012 regulation of small molecule metabolic process 3.876E-7 1.596E-3 2.073E-5 1.845E-4 15 458 GDF15,CH25H,APOC1,APOE,PTGS2,TFF3,BMP6,IGFBP3,TRIB3,EGR1,IER3,TNF,SNAI1,IL6,CNR1 GO: Biological Process GO:0034612 response to tumor necrosis factor 4.406E-7 1.815E-3 2.286E-5 2.034E-4 12 285 ZC3H12A,FOS,CHI3L1,F2RL1,PTGS2,CRHBP,TNFRSF4,KLF2,HES1,TNF,IL6,EDA2R GO: Biological Process GO:0043066 negative regulation of apoptotic process 4.421E-7 1.821E-3 2.286E-5 2.034E-4 24 1142 NPPC,ZC3H12A,SFRP2,COMP,SOCS3,NR4A2,TNFRSF10D,SOX8,APOE,F2R,PTGFR,PTGS2,BDKRB2,SLC2A3,TNFRSF4,MSX1,IER3,EGR3,PLAUR,TNF,SNAI1,CCL21,PLK3,IL6 GO: Biological Process GO:0014075 response to amine 4.439E-7 1.828E-3 2.286E-5 2.034E-4 7 71 FOSB,NR4A2,NR4A1,CXCL1,CXCL2,CXCL3,RGS4 GO: Biological Process GO:0001932 regulation of protein phosphorylation 4.603E-7 1.896E-3 2.341E-5 2.084E-4 22 978 ZC3H12A,SFRP2,INHBA,DUSP6,SOCS3,NOX4,CHI3L1,APOE,BDKRB2,AREG,TNFRSF4,LIF,BMP6,THBS4,IGFBP3,CSF3,TRIB3,HES1,PLAUR,TNF,HES5,IL6 GO: Biological Process GO:0018108 peptidyl-tyrosine phosphorylation 5.109E-7 2.104E-3 2.566E-5 2.284E-4 12 289 SFRP2,SOCS3,NOX4,AREG,LIF,BMP6,THBS4,CSF3,HES1,TNF,HES5,IL6 GO: Biological Process GO:0051093 negative regulation of developmental process 5.297E-7 2.182E-3 2.629E-5 2.340E-4 25 1240 NPPC,ZC3H12A,SFRP2,ANGPT2,INHBA,CXCL10,GDF15,SOX8,APOE,RGS4,AREG,KLF2,NRARP,MSX1,LIF,THBS4,TRIB3,FRZB,HES1,CLDN5,TNF,SNAI1,CCL21,HES5,IL6 GO: Biological Process GO:0018212 peptidyl-tyrosine modification 5.911E-7 2.435E-3 2.898E-5 2.580E-4 12 293 SFRP2,SOCS3,NOX4,AREG,LIF,BMP6,THBS4,CSF3,HES1,TNF,HES5,IL6 GO: Biological Process GO:0003018 vascular process in circulatory system 6.985E-7 2.877E-3 3.385E-5 3.013E-4 13 355 NPPC,COMP,DUSP5,APOE,F2R,F2RL1,PTGS2,BDKRB2,SLC2A3,KLF2,BMP6,CLDN5,TNF GO: Biological Process GO:0070371 ERK1 and ERK2 cascade 8.320E-7 3.427E-3 3.985E-5 3.547E-4 14 422 INHBA,DUSP5,DUSP6,NOX4,LMO3,CHI3L1,APOE,F2R,F2RL1,LIF,TNF,CCL21,IL6,TPBG GO: Biological Process GO:0043069 negative regulation of programmed cell death 8.688E-7 3.579E-3 4.113E-5 3.661E-4 24 1186 NPPC,ZC3H12A,SFRP2,COMP,SOCS3,NR4A2,TNFRSF10D,SOX8,APOE,F2R,PTGFR,PTGS2,BDKRB2,SLC2A3,TNFRSF4,MSX1,IER3,EGR3,PLAUR,TNF,SNAI1,CCL21,PLK3,IL6 GO: Biological Process GO:0009611 response to wounding 9.257E-7 3.813E-3 4.333E-5 3.856E-4 18 703 NPPC,ANGPT2,COMP,INHBA,INHBB,CHMP4BP1,APOD,APOE,F2R,F2RL1,F2RL2,FOSL1,MMRN1,PDIA2,PLAT,PLAUR,TNF,IL6 GO: Biological Process GO:0009628 response to abiotic stimulus 9.716E-7 4.002E-3 4.497E-5 4.002E-4 27 1463 DNAJB1,NPPC,SFRP2,ANGPT2,INHBA,CXCL10,FOS,FOSB,NR4A2,CHI3L1,NR4A1,CXCL1,CXCL2,BHLHE40,CXCL3,PTGS2,BDKRB2,STC1,FOSL1,LIF,BMP6,EGR1,PLAT,TNF,MME,HSPA6,PLK3 GO: Biological Process GO:0072170 metanephric tubule development 1.024E-6 4.216E-3 4.685E-5 4.170E-4 5 28 GDF6,SOX8,LIF,HES1,HES5 GO: Biological Process GO:0070848 response to growth factor 1.038E-6 4.274E-3 4.697E-5 4.181E-4 21 944 SFRP2,SFRP4,ANGPT2,COMP,GDF15,FOS,DUSP6,GDF6,NR4A1,GDF10,MMRN1,MSX1,BMP6,EGR1,EGR3,HES1,CLDN5,HAS1,HES5,IL6,ADAMTSL2 GO: Biological Process GO:0044703 multi-organism reproductive process 1.108E-6 4.562E-3 4.881E-5 4.344E-4 12 311 ANGPT2,FOS,FOSB,PTGFR,PTGS2,CRHBP,STC1,FOSL1,LIF,JUNB,MAFF,CNR1 GO: Biological Process GO:0051048 negative regulation of secretion 1.114E-6 4.588E-3 4.881E-5 4.344E-4 11 256 INHBA,INHBB,APOE,F2R,F2RL1,CRHBP,LIF,IGFBP3,TNF,IL6,CNR1 GO: Biological Process GO:0071356 cellular response to tumor necrosis factor 1.114E-6 4.588E-3 4.881E-5 4.344E-4 11 256 ZC3H12A,FOS,CHI3L1,F2RL1,CRHBP,TNFRSF4,KLF2,HES1,TNF,IL6,EDA2R GO: Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway 1.144E-6 4.710E-3 4.958E-5 4.413E-4 9 159 SFRP2,SFRP4,SOX17,APOE,EGR1,FRZB,DKK2,TPBG,SHISA3 GO: Biological Process GO:0042325 regulation of phosphorylation 1.204E-6 4.960E-3 5.167E-5 4.599E-4 22 1036 ZC3H12A,SFRP2,INHBA,DUSP6,SOCS3,NOX4,CHI3L1,APOE,BDKRB2,AREG,TNFRSF4,LIF,BMP6,THBS4,IGFBP3,CSF3,TRIB3,HES1,PLAUR,TNF,HES5,IL6 GO: Biological Process GO:0001649 osteoblast differentiation 1.398E-6 5.758E-3 5.912E-5 5.262E-4 12 318 NPPC,SFRP2,SHOX2,SOX8,GDF10,AREG,BMP6,JUNB,IGFBP3,TNF,SNAI1,IL6 GO: Biological Process GO:0046683 response to organophosphorus 1.407E-6 5.794E-3 5.912E-5 5.262E-4 9 163 INHBB,NT5E,FOS,FOSB,PTGS2,CRHBP,AREG,STC1,FOSL1 GO: Biological Process GO:0043409 negative regulation of MAPK cascade 1.448E-6 5.965E-3 6.000E-5 5.340E-4 10 211 SFRP2,SFRP4,DUSP2,DUSP5,DUSP6,LMO3,APOE,F2RL1,LIF,TRIB3 GO: Biological Process GO:0007155 cell adhesion 1.457E-6 6.000E-3 6.000E-5 5.340E-4 29 1684 ZC3H12A,SFRP2,ANGPT2,COMP,NT5E,HLA-DQA2,HLA-DQB2,PCDHB2,LAMC3,APOD,CD83,OMD,NRARP,MMRN1,LIF,BMP6,THBS4,EGR3,TREM1,PDIA2,HES1,PLAUR,CLDN5,TNF,HAS1,CCL21,HES5,IL6,TPBG GO: Biological Process GO:0044706 multi-multicellular organism process 1.492E-6 6.147E-3 6.086E-5 5.417E-4 12 320 ANGPT2,FOS,FOSB,PTGFR,PTGS2,CRHBP,STC1,FOSL1,LIF,JUNB,MAFF,CNR1 GO: Biological Process GO:0035296 regulation of tube diameter 1.577E-6 6.496E-3 6.307E-5 5.614E-4 10 213 NPPC,COMP,DUSP5,APOE,F2R,F2RL1,PTGS2,BDKRB2,KLF2,TNF GO: Biological Process GO:0097746 blood vessel diameter maintenance 1.577E-6 6.496E-3 6.307E-5 5.614E-4 10 213 NPPC,COMP,DUSP5,APOE,F2R,F2RL1,PTGS2,BDKRB2,KLF2,TNF GO: Biological Process GO:0001503 ossification 1.643E-6 6.768E-3 6.454E-5 5.744E-4 16 584 NPPC,SFRP2,COMP,SHOX2,SOX8,GDF10,PTGS2,AREG,STC1,BMP6,JUNB,IGFBP3,EGR2,TNF,SNAI1,IL6 GO: Biological Process GO:0035150 regulation of tube size 1.645E-6 6.777E-3 6.454E-5 5.744E-4 10 214 NPPC,COMP,DUSP5,APOE,F2R,F2RL1,PTGS2,BDKRB2,KLF2,TNF GO: Biological Process GO:0072207 metanephric epithelium development 1.742E-6 7.174E-3 6.768E-5 6.024E-4 5 31 GDF6,SOX8,LIF,HES1,HES5 GO: Biological Process GO:0045598 regulation of fat cell differentiation 1.808E-6 7.447E-3 6.904E-5 6.145E-4 9 168 ZC3H12A,SFRP2,LMO3,PTGS2,TRIB3,FRZB,HES1,TNF,IL6 GO: Biological Process GO:0030334 regulation of cell migration 1.822E-6 7.506E-3 6.904E-5 6.145E-4 24 1237 ZC3H12A,SFRP2,ANGPT2,CXCL10,GDF15,NOX4,APOD,APOE,F2R,F2RL1,PTGS2,STC1,MMRN1,THBS4,IGFBP3,EGR1,TREM1,CLDN5,TNF,CCL14,SNAI1,HAS1,CCL21,IL6 GO: Biological Process GO:0070372 regulation of ERK1 and ERK2 cascade 1.827E-6 7.525E-3 6.904E-5 6.145E-4 13 387 INHBA,DUSP6,NOX4,LMO3,CHI3L1,APOE,F2R,F2RL1,LIF,TNF,CCL21,IL6,TPBG GO: Biological Process GO:0071363 cellular response to growth factor stimulus 2.362E-6 9.729E-3 8.844E-5 7.872E-4 20 911 SFRP2,SFRP4,ANGPT2,COMP,GDF15,FOS,GDF6,NR4A1,GDF10,MMRN1,MSX1,BMP6,EGR1,EGR3,HES1,CLDN5,HAS1,HES5,IL6,ADAMTSL2 GO: Biological Process GO:0050886 endocrine process 2.461E-6 1.014E-2 9.132E-5 8.128E-4 8 130 INHBA,INHBB,F2R,F2RL1,CRHBP,LIF,BMP6,MME GO: Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II 2.644E-6 1.089E-2 9.695E-5 8.629E-4 22 1087 DNAJB1,ZC3H12A,SFRP4,FOSB,NR4A2,SOX18,SHOX2,SOX8,BHLHE40,TNFRSF4,KLF2,NRARP,MSX1,BMP6,TRIB3,EGR1,HES1,TNF,MAFF,SNAI1,HES5,PLK3 GO: Biological Process GO:0007596 blood coagulation 2.660E-6 1.096E-2 9.695E-5 8.629E-4 11 280 ANGPT2,COMP,APOE,F2R,F2RL1,F2RL2,MMRN1,PDIA2,PLAT,PLAUR,IL6 GO: Biological Process GO:0040012 regulation of locomotion 2.792E-6 1.150E-2 1.009E-4 8.979E-4 25 1359 ZC3H12A,SFRP2,ANGPT2,CXCL10,GDF15,NOX4,APOD,APOE,F2R,F2RL1,PTGS2,STC1,MMRN1,THBS4,IGFBP3,EGR1,TREM1,CLDN5,TNF,CCL14,SNAI1,HAS1,CCL21,IL6,TPBG GO: Biological Process GO:0009887 animal organ morphogenesis 3.120E-6 1.285E-2 1.118E-4 9.948E-4 24 1276 NPPC,SFRP2,SFRP4,COMP,INHBA,SOX17,ETV4,SOX18,SHOX2,LAMC3,SOX8,AREG,STC1,MSX1,LIF,BMP6,FRZB,HES1,CLDN5,TNF,SNAI1,HES5,IL6,PRRX2 GO: Biological Process GO:0050817 coagulation 3.261E-6 1.343E-2 1.150E-4 1.023E-3 11 286 ANGPT2,COMP,APOE,F2R,F2RL1,F2RL2,MMRN1,PDIA2,PLAT,PLAUR,IL6 GO: Biological Process GO:1903531 negative regulation of secretion by cell 3.265E-6 1.345E-2 1.150E-4 1.023E-3 10 231 INHBA,INHBB,APOE,F2R,F2RL1,CRHBP,LIF,IGFBP3,IL6,CNR1 GO: Biological Process GO:0048660 regulation of smooth muscle cell proliferation 3.393E-6 1.398E-2 1.178E-4 1.049E-3 10 232 NPPC,APOD,APOE,PTGIR,PTGS2,IGFBP3,EGR1,TNF,HES5,IL6 GO: Biological Process GO:1904894 positive regulation of receptor signaling pathway via STAT 3.404E-6 1.402E-2 1.178E-4 1.049E-3 6 62 F2R,LIF,HES1,TNF,HES5,IL6 GO: Biological Process GO:0007599 hemostasis 3.487E-6 1.436E-2 1.197E-4 1.065E-3 11 288 ANGPT2,COMP,APOE,F2R,F2RL1,F2RL2,MMRN1,PDIA2,PLAT,PLAUR,IL6 GO: Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 3.526E-6 1.452E-2 1.200E-4 1.068E-3 10 233 GDF15,NOX4,CHI3L1,F2R,F2RL1,CSF3,TNF,CCL21,IL6,TPBG GO: Biological Process GO:0061061 muscle structure development 3.961E-6 1.632E-2 1.337E-4 1.190E-3 19 860 COMP,CXCL10,GDF15,FOS,SHOX2,NOX4,NR4A1,SOX8,RGS4,MSX1,LIF,IGFBP3,EGR1,EGR2,EGR3,HES1,TNF,MAFF,IL6 GO: Biological Process GO:0001501 skeletal system development 4.003E-6 1.649E-2 1.341E-4 1.193E-3 16 626 NPPC,SFRP2,SFRP4,COMP,GDF6,SHOX2,CHI3L1,GDF10,STC1,MSX1,BMP6,PRELP,FRZB,SNAI1,HES5,PRRX2 GO: Biological Process GO:0014074 response to purine-containing compound 4.177E-6 1.720E-2 1.387E-4 1.235E-3 9 186 INHBB,NT5E,FOS,FOSB,PTGS2,CRHBP,AREG,STC1,FOSL1 GO: Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade 4.419E-6 1.820E-2 1.456E-4 1.296E-3 10 239 INHBA,NOX4,CHI3L1,APOE,F2R,F2RL1,TNF,CCL21,IL6,TPBG GO: Biological Process GO:0002009 morphogenesis of an epithelium 4.518E-6 1.861E-2 1.477E-4 1.315E-3 16 632 SFRP2,CXCL10,SOCS3,SOX17,ETV4,SOX18,SOX8,AREG,NRARP,LIF,FRZB,HES1,TNF,SNAI1,HES5,IL6 GO: Biological Process GO:0045471 response to ethanol 4.558E-6 1.877E-2 1.478E-4 1.316E-3 9 188 NPPC,FOS,FOSB,RGS4,CRHBP,CSF3,CLDN5,TNF,CNR1 GO: Biological Process GO:0048659 smooth muscle cell proliferation 4.757E-6 1.959E-2 1.511E-4 1.345E-3 10 241 NPPC,APOD,APOE,PTGIR,PTGS2,IGFBP3,EGR1,TNF,HES5,IL6 GO: Biological Process GO:0003158 endothelium development 4.759E-6 1.960E-2 1.511E-4 1.345E-3 9 189 CXCL10,SOX17,SOX18,F2RL1,STC1,BMP6,APOLD1,CLDN5,TNF GO: Biological Process GO:2000145 regulation of cell motility 4.768E-6 1.964E-2 1.511E-4 1.345E-3 24 1308 ZC3H12A,SFRP2,ANGPT2,CXCL10,GDF15,NOX4,APOD,APOE,F2R,F2RL1,PTGS2,STC1,MMRN1,THBS4,IGFBP3,EGR1,TREM1,CLDN5,TNF,CCL14,SNAI1,HAS1,CCL21,IL6 GO: Biological Process GO:0001656 metanephros development 4.870E-6 2.006E-2 1.531E-4 1.363E-3 7 101 GDF6,SOX17,SOX8,LIF,EGR1,HES1,HES5 GO: Biological Process GO:0009617 response to bacterium 5.188E-6 2.137E-2 1.619E-4 1.441E-3 20 960 ZC3H12A,CXCL10,FOS,NR4A1,F2R,F2RL1,CXCL1,CXCL2,PTGFR,CXCL3,PTGIR,RGS1,PTGS2,BMP6,CSF3,SLPI,TREM1,TNF,IL6,CNR1 GO: Biological Process GO:0060070 canonical Wnt signaling pathway 5.310E-6 2.187E-2 1.644E-4 1.464E-3 12 362 SFRP2,SFRP4,NR4A2,SOX17,APOE,NRARP,EGR1,FRZB,SNAI1,DKK2,TPBG,SHISA3 GO: Biological Process GO:0045765 regulation of angiogenesis 5.484E-6 2.259E-2 1.686E-4 1.500E-3 13 428 ZC3H12A,SFRP2,ANGPT2,CXCL10,CLIC3,CHI3L1,KLF2,LIF,THBS4,PROK1,CLDN5,TNF,IL6 GO: Biological Process GO:0030593 neutrophil chemotaxis 5.549E-6 2.286E-2 1.693E-4 1.507E-3 7 103 CXCL10,CXCL1,CXCL2,CXCL3,THBS4,TREM1,CCL21 GO: Biological Process GO:0051247 positive regulation of protein metabolic process 6.244E-6 2.572E-2 1.891E-4 1.683E-3 23 1237 ZC3H12A,SFRP2,INHBA,SOX17,NOX4,CHI3L1,APOE,AREG,KLF2,LIF,BMP6,THBS4,CSF3,TRIB3,EGR1,IER3,HES1,PLAUR,TNF,CCL21,HES5,PLK3,IL6 GO: Biological Process GO:0046425 regulation of receptor signaling pathway via JAK-STAT 6.305E-6 2.597E-2 1.896E-4 1.687E-3 7 105 SOCS3,F2R,LIF,HES1,TNF,HES5,IL6 GO: Biological Process GO:0042509 regulation of tyrosine phosphorylation of STAT protein 6.391E-6 2.632E-2 1.908E-4 1.698E-3 6 69 SOCS3,LIF,HES1,TNF,HES5,IL6 GO: Biological Process GO:0050890 cognition 6.693E-6 2.757E-2 1.975E-4 1.758E-3 13 436 FOS,NR4A2,APOE,PTGS2,CRHBP,FOSL1,EGR1,EGR2,CLDN5,TNF,MME,CNR1,TPBG GO: Biological Process GO:0046888 negative regulation of hormone secretion 6.713E-6 2.765E-2 1.975E-4 1.758E-3 7 106 INHBA,INHBB,F2RL1,CRHBP,LIF,IGFBP3,IL6 GO: Biological Process GO:1901342 regulation of vasculature development 7.030E-6 2.896E-2 2.054E-4 1.828E-3 13 438 ZC3H12A,SFRP2,ANGPT2,CXCL10,CLIC3,CHI3L1,KLF2,LIF,THBS4,PROK1,CLDN5,TNF,IL6 GO: Biological Process GO:0048708 astrocyte differentiation 7.144E-6 2.943E-2 2.072E-4 1.844E-3 7 107 LAMC3,SOX8,LIF,HES1,TNF,HES5,IL6 GO: Biological Process GO:0030178 negative regulation of Wnt signaling pathway 7.230E-6 2.978E-2 2.083E-4 1.854E-3 9 199 SFRP2,SFRP4,SOX17,APOE,EGR1,FRZB,DKK2,TPBG,SHISA3 GO: Biological Process GO:0030097 hemopoiesis 7.312E-6 3.012E-2 2.091E-4 1.862E-3 23 1249 ZC3H12A,SFRP2,ANGPT2,INHBA,HLA-DQA2,FOS,SOCS3,CD83,F2RL1,CXCL2,KLF2,NRARP,LIF,JUNB,CSF3,EGR1,EGR3,HES1,TNF,CCL21,PRG4,HES5,IL6 GO: Biological Process GO:0032355 response to estradiol 7.489E-6 3.085E-2 2.127E-4 1.894E-3 8 151 SSTR1,CXCL1,CXCL2,PTGFR,CXCL3,PTGS2,CRHBP,AREG GO: Biological Process GO:0019216 regulation of lipid metabolic process 7.564E-6 3.116E-2 2.134E-4 1.899E-3 13 441 GDF15,SPATA18,CH25H,APOC1,APOD,APOE,PTGS2,BMP6,TRIB3,EGR1,TNF,SNAI1,CNR1 GO: Biological Process GO:0072210 metanephric nephron development 8.226E-6 3.388E-2 2.305E-4 2.051E-3 5 42 SOX8,LIF,EGR1,HES1,HES5 GO: Biological Process GO:0045833 negative regulation of lipid metabolic process 9.074E-6 3.738E-2 2.525E-4 2.248E-3 8 155 CH25H,APOC1,APOD,APOE,TRIB3,TNF,SNAI1,CNR1 GO: Biological Process GO:0030509 BMP signaling pathway 9.187E-6 3.784E-2 2.540E-4 2.260E-3 9 205 SFRP2,SFRP4,COMP,GDF6,MSX1,BMP6,EGR1,HES1,HES5 GO: Biological Process GO:0050678 regulation of epithelial cell proliferation 9.321E-6 3.839E-2 2.560E-4 2.278E-3 14 520 SFRP2,ETV4,NR4A1,APOE,AREG,NRARP,BMP6,THBS4,EGR3,HES1,PROK1,TNF,HES5,IL6 GO: Biological Process GO:2000630 positive regulation of miRNA metabolic process 9.612E-6 3.959E-2 2.610E-4 2.323E-3 6 74 ZC3H12A,FOS,FOSL1,EGR1,TNF,IL6 GO: Biological Process GO:0007611 learning or memory 9.631E-6 3.967E-2 2.610E-4 2.323E-3 12 384 FOS,NR4A2,APOE,PTGS2,CRHBP,FOSL1,EGR1,EGR2,CLDN5,MME,CNR1,TPBG GO: Biological Process GO:0048866 stem cell fate specification 9.723E-6 4.005E-2 2.617E-4 2.330E-3 3 7 SFRP2,SOX17,SOX18 GO: Biological Process GO:0031399 regulation of protein modification process 1.009E-5 4.155E-2 2.698E-4 2.401E-3 23 1274 ZC3H12A,SFRP2,INHBA,DUSP6,SOCS3,NOX4,CHI3L1,APOE,BDKRB2,AREG,TNFRSF4,LIF,BMP6,THBS4,IGFBP3,CSF3,TRIB3,EGR1,HES1,PLAUR,TNF,HES5,IL6 GO: Biological Process GO:0032101 regulation of response to external stimulus 1.015E-5 4.182E-2 2.698E-4 2.401E-3 24 1368 ZC3H12A,ANGPT2,CXCL10,NT5E,SOCS3,APOE,F2R,F2RL1,CXCL2,PTGS2,FOSL1,MMRN1,BMP6,THBS4,IER3,TREM1,PLAT,PLAUR,TNF,CCL21,DNASE1L3,IL6,CNR1,TPBG GO: Biological Process GO:0007260 tyrosine phosphorylation of STAT protein 1.039E-5 4.280E-2 2.744E-4 2.442E-3 6 75 SOCS3,LIF,HES1,TNF,HES5,IL6 GO: Biological Process GO:0001890 placenta development 1.073E-5 4.419E-2 2.815E-4 2.505E-3 9 209 SOCS3,PTGS2,STC1,FOSL1,LIF,JUNB,HES1,MME,SNAI1 GO: Biological Process GO:0051591 response to cAMP 1.085E-5 4.469E-2 2.828E-4 2.517E-3 7 114 INHBB,FOS,FOSB,CRHBP,AREG,STC1,FOSL1 GO: Biological Process GO:0050900 leukocyte migration 1.132E-5 4.663E-2 2.933E-4 2.610E-3 13 458 CXCL10,GDF15,CH25H,APOD,F2RL1,CXCL1,CXCL2,CXCL3,THBS4,TREM1,TNF,CCL21,IL6