Category ID Name Source p-value q-value Bonferroni q-value FDR B&H q-value FDR B&Y Hit Count in Query List Hit Count in Genome Hit in Query List GO: Molecular Function GO:0004767 sphingomyelin phosphodiesterase activity 1.686E-7 3.810E-5 3.810E-5 2.286E-4 3 8 ENPP7,SMPDL3B,SMPDL3A GO: Molecular Function GO:0052713 inositol phosphorylceramide phospholipase activity 3.245E-5 7.333E-3 9.494E-4 5.696E-3 2 6 SMPDL3B,SMPDL3A GO: Molecular Function GO:0052715 mannosyl-diinositol phosphorylceramide phospholipase activity 3.245E-5 7.333E-3 9.494E-4 5.696E-3 2 6 SMPDL3B,SMPDL3A GO: Molecular Function GO:0044688 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity 3.245E-5 7.333E-3 9.494E-4 5.696E-3 2 6 SMPDL3B,SMPDL3A GO: Molecular Function GO:0004120 photoreceptor cyclic-nucleotide phosphodiesterase activity 3.245E-5 7.333E-3 9.494E-4 5.696E-3 2 6 SMPDL3B,SMPDL3A GO: Molecular Function GO:0052714 mannosyl-inositol phosphorylceramide phospholipase activity 3.245E-5 7.333E-3 9.494E-4 5.696E-3 2 6 SMPDL3B,SMPDL3A GO: Molecular Function GO:0052712 inositol phosphosphingolipid phospholipase activity 3.245E-5 7.333E-3 9.494E-4 5.696E-3 2 6 SMPDL3B,SMPDL3A GO: Molecular Function GO:0004620 phospholipase activity 3.361E-5 7.595E-3 9.494E-4 5.696E-3 4 124 PLBD1,ENPP7,SMPDL3B,SMPDL3A GO: Molecular Function GO:0016298 lipase activity 5.107E-5 1.154E-2 1.282E-3 7.695E-3 4 138 PLBD1,ENPP7,SMPDL3B,SMPDL3A GO: Molecular Function GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity 6.045E-5 1.366E-2 1.350E-3 8.100E-3 2 8 SMPDL3B,SMPDL3A GO: Molecular Function GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 7.765E-5 1.755E-2 1.350E-3 8.100E-3 2 9 SMPDL3B,SMPDL3A GO: Molecular Function GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity 7.765E-5 1.755E-2 1.350E-3 8.100E-3 2 9 SMPDL3B,SMPDL3A GO: Molecular Function GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 7.765E-5 1.755E-2 1.350E-3 8.100E-3 2 9 ALDH1L1,ADH4 GO: Molecular Function GO:0008081 phosphoric diester hydrolase activity 4.183E-4 9.453E-2 6.752E-3 4.051E-2 3 98 ENPP7,SMPDL3B,SMPDL3A GO: Molecular Function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4.923E-4 1.113E-1 7.417E-3 4.450E-2 2 22 SMPDL3B,SMPDL3A GO: Molecular Function GO:0017124 SH3 domain binding 8.116E-4 1.834E-1 1.146E-2 6.878E-2 3 123 PAK3,DPYSL3,ARHGAP31 GO: Molecular Function GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 9.202E-4 2.080E-1 1.223E-2 7.340E-2 2 30 SMPDL3B,SMPDL3A GO: Molecular Function GO:0004112 cyclic-nucleotide phosphodiesterase activity 9.827E-4 2.221E-1 1.234E-2 7.403E-2 2 31 SMPDL3B,SMPDL3A GO: Molecular Function GO:0004629 phospholipase C activity 1.400E-3 3.163E-1 1.405E-2 8.431E-2 2 37 SMPDL3B,SMPDL3A GO: Molecular Function GO:0015334 high-affinity oligopeptide transmembrane transporter activity 1.503E-3 3.396E-1 1.405E-2 8.431E-2 1 1 SLC15A2 GO: Molecular Function GO:0005503 all-trans retinal binding 1.503E-3 3.396E-1 1.405E-2 8.431E-2 1 1 ADH4 GO: Molecular Function GO:0033721 aldehyde dehydrogenase (NADP+) activity 1.503E-3 3.396E-1 1.405E-2 8.431E-2 1 1 ALDH1L1 GO: Molecular Function GO:0035731 dinitrosyl-iron complex binding 1.503E-3 3.396E-1 1.405E-2 8.431E-2 1 1 GSTP1 GO: Molecular Function GO:0035730 S-nitrosoglutathione binding 1.503E-3 3.396E-1 1.405E-2 8.431E-2 1 1 GSTP1 GO: Molecular Function GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1.554E-3 3.513E-1 1.405E-2 8.431E-2 2 39 ALDH1L1,ADH4 GO: Molecular Function GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.444E-3 5.524E-1 2.118E-2 1.271E-1 2 49 ALDH1L1,ADH4 GO: Molecular Function GO:0016403 dimethylargininase activity 2.999E-3 6.777E-1 2.118E-2 1.271E-1 1 2 DDAH1 GO: Molecular Function GO:0047522 15-oxoprostaglandin 13-oxidase activity 2.999E-3 6.777E-1 2.118E-2 1.271E-1 1 2 PTGR2 GO: Molecular Function GO:0016155 formyltetrahydrofolate dehydrogenase activity 2.999E-3 6.777E-1 2.118E-2 1.271E-1 1 2 ALDH1L1 GO: Molecular Function GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity 2.999E-3 6.777E-1 2.118E-2 1.271E-1 1 2 SLC28A1 GO: Molecular Function GO:0019115 benzaldehyde dehydrogenase activity 2.999E-3 6.777E-1 2.118E-2 1.271E-1 1 2 ADH4 GO: Molecular Function GO:0036132 13-prostaglandin reductase activity 2.999E-3 6.777E-1 2.118E-2 1.271E-1 1 2 PTGR2 GO: Molecular Function GO:0070026 nitric oxide binding 4.495E-3 1.000E0 2.712E-2 1.627E-1 1 3 GSTP1 GO: Molecular Function GO:0005350 pyrimidine nucleobase transmembrane transporter activity 4.495E-3 1.000E0 2.712E-2 1.627E-1 1 3 SLC28A1 GO: Molecular Function GO:0042895 antibiotic transmembrane transporter activity 4.495E-3 1.000E0 2.712E-2 1.627E-1 1 3 SLC15A2 GO: Molecular Function GO:0035374 chondroitin sulfate binding 4.495E-3 1.000E0 2.712E-2 1.627E-1 1 3 DPYSL3 GO: Molecular Function GO:0005415 nucleoside:sodium symporter activity 4.495E-3 1.000E0 2.712E-2 1.627E-1 1 3 SLC28A1 GO: Molecular Function GO:0004175 endopeptidase activity 4.561E-3 1.000E0 2.712E-2 1.627E-1 4 457 CAPN9,CELA1,CLCA1,MMP14 GO: Molecular Function GO:0015333 peptide:proton symporter activity 5.989E-3 1.000E0 3.076E-2 1.846E-1 1 4 SLC15A2 GO: Molecular Function GO:0035276 ethanol binding 5.989E-3 1.000E0 3.076E-2 1.846E-1 1 4 ADH4 GO: Molecular Function GO:0003960 NADPH:quinone reductase activity 5.989E-3 1.000E0 3.076E-2 1.846E-1 1 4 ADH4 GO: Molecular Function GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity 5.989E-3 1.000E0 3.076E-2 1.846E-1 1 4 ALDH1L1 GO: Molecular Function GO:0022897 proton-dependent peptide secondary active transmembrane transporter activity 5.989E-3 1.000E0 3.076E-2 1.846E-1 1 4 SLC15A2 GO: Molecular Function GO:0019145 aminobutyraldehyde dehydrogenase activity 5.989E-3 1.000E0 3.076E-2 1.846E-1 1 4 ALDH1L1 GO: Molecular Function GO:0008270 zinc ion binding 7.738E-3 1.000E0 3.886E-2 2.332E-1 6 1200 S100A6,PTGR2,DDAH1,MMP14,SMPDL3A,ADH4 GO: Molecular Function GO:0004024 alcohol dehydrogenase activity, zinc-dependent 8.970E-3 1.000E0 4.223E-2 2.534E-1 1 6 ADH4 GO: Molecular Function GO:0005345 purine nucleobase transmembrane transporter activity 8.970E-3 1.000E0 4.223E-2 2.534E-1 1 6 SLC28A1 GO: Molecular Function GO:0008131 primary amine oxidase activity 8.970E-3 1.000E0 4.223E-2 2.534E-1 1 6 MAOB GO: Molecular Function GO:0015294 solute:cation symporter activity 9.441E-3 1.000E0 4.355E-2 2.613E-1 2 98 SLC28A1,SLC15A2 GO: Biological Process GO:0006685 sphingomyelin catabolic process 9.475E-8 8.423E-5 4.864E-5 3.584E-4 3 7 ENPP7,SMPDL3B,SMPDL3A GO: Biological Process GO:1901616 organic hydroxy compound catabolic process 1.094E-7 9.729E-5 4.864E-5 3.584E-4 5 82 ENPP7,SMPDL3B,MAOB,SMPDL3A,ADH4 GO: Biological Process GO:0006684 sphingomyelin metabolic process 9.788E-7 8.701E-4 2.900E-4 2.137E-3 3 14 ENPP7,SMPDL3B,SMPDL3A GO: Biological Process GO:0046164 alcohol catabolic process 2.523E-6 2.243E-3 5.607E-4 4.131E-3 4 67 ENPP7,SMPDL3B,SMPDL3A,ADH4 GO: Biological Process GO:0030149 sphingolipid catabolic process 5.390E-6 4.792E-3 9.583E-4 7.061E-3 3 24 ENPP7,SMPDL3B,SMPDL3A GO: Biological Process GO:0097164 ammonium ion metabolic process 6.700E-6 5.957E-3 9.864E-4 7.268E-3 5 188 PLBD1,ENPP7,SMPDL3B,MAOB,SMPDL3A GO: Biological Process GO:0046466 membrane lipid catabolic process 7.767E-6 6.905E-3 9.864E-4 7.268E-3 3 27 ENPP7,SMPDL3B,SMPDL3A GO: Biological Process GO:0042439 ethanolamine-containing compound metabolic process 9.366E-6 8.326E-3 9.925E-4 7.313E-3 4 93 PLBD1,ENPP7,SMPDL3B,SMPDL3A GO: Biological Process GO:0044106 cellular amine metabolic process 1.120E-5 9.961E-3 9.925E-4 7.313E-3 5 209 PLBD1,ENPP7,SMPDL3B,MAOB,SMPDL3A GO: Biological Process GO:1901565 organonitrogen compound catabolic process 1.137E-5 1.011E-2 9.925E-4 7.313E-3 6 365 ENPP7,ALDH1L1,DDAH1,SMPDL3B,MAOB,SMPDL3A GO: Biological Process GO:0044282 small molecule catabolic process 1.228E-5 1.092E-2 9.925E-4 7.313E-3 6 370 ENPP7,ALDH1L1,DDAH1,SMPDL3B,SMPDL3A,ADH4 GO: Biological Process GO:0009308 amine metabolic process 1.374E-5 1.221E-2 1.018E-3 7.499E-3 5 218 PLBD1,ENPP7,SMPDL3B,MAOB,SMPDL3A GO: Biological Process GO:0009395 phospholipid catabolic process 3.004E-5 2.671E-2 2.055E-3 1.514E-2 3 42 ENPP7,SMPDL3B,SMPDL3A GO: Biological Process GO:0006576 cellular biogenic amine metabolic process 3.513E-5 3.123E-2 2.231E-3 1.643E-2 4 130 PLBD1,ENPP7,SMPDL3B,SMPDL3A GO: Biological Process GO:1901615 organic hydroxy compound metabolic process 1.409E-4 1.253E-1 8.351E-3 6.153E-2 6 573 PLBD1,ENPP7,SMPDL3B,MAOB,SMPDL3A,ADH4 GO: Biological Process GO:0006066 alcohol metabolic process 2.671E-4 2.374E-1 1.484E-2 1.093E-1 5 408 PLBD1,ENPP7,SMPDL3B,SMPDL3A,ADH4 GO: Biological Process GO:0016042 lipid catabolic process 8.973E-4 7.977E-1 4.692E-2 3.457E-1 4 303 PLBD1,ENPP7,SMPDL3B,SMPDL3A Pathway 83032 Drug metabolism - cytochrome P450 BioSystems: KEGG 1.546E-4 7.577E-3 6.405E-3 2.869E-2 3 70 GSTP1,MAOB,ADH4 Pathway PW:0000052 tyrosine metabolic Pathway Ontology 2.614E-4 1.281E-2 6.405E-3 2.869E-2 2 16 MAOB,ADH4 Pathway 82959 Tyrosine metabolism BioSystems: KEGG 1.274E-3 6.243E-2 2.081E-2 9.321E-2 2 35 MAOB,ADH4